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Articles 5071 - 5100 of 114119
Full-Text Articles in Entire DC Network
Maximizing Germination Of Three Native Plants For Rangeland Restoration And Urban Landscapes Through Seed Enhancements, Janetta Teichert
Maximizing Germination Of Three Native Plants For Rangeland Restoration And Urban Landscapes Through Seed Enhancements, Janetta Teichert
Theses and Dissertations
Native plants offer numerous ecological benefits and opportunities for both rangeland restoration and urban landscaping, making their integration essential for building sustainable ecosystems. They enhance soil health, promote pollinator activity, increase microbial diversity, and support both wildlife and livestock, all of which contribute to overall ecosystem resilience. A promising strategy to improve the use of native plants is the application of seed enhancement technologies, which can optimize seed germination, improve seedling establishment, and enhance overall plant success in challenging environments. These post-harvest seed treatments incorporate materials that improve seed performance, often through coatings composed of binders, fillers, and active ingredients. …
Phytochemistry, Antioxidant And Cytotoxic Activities Of Hibiscus (Hibiscus Rosa-Sinensis) Extract On Mcf-7 Breast Cancer Cells, Ade Arsianti, Isma Zahira Suhaima, Steven Gill, Ajeng Megawati Fajrin, Lince Dameria Nadapdap, Norma Nur Azizah, Hiroki Tanimoto, Shun Hirota
Phytochemistry, Antioxidant And Cytotoxic Activities Of Hibiscus (Hibiscus Rosa-Sinensis) Extract On Mcf-7 Breast Cancer Cells, Ade Arsianti, Isma Zahira Suhaima, Steven Gill, Ajeng Megawati Fajrin, Lince Dameria Nadapdap, Norma Nur Azizah, Hiroki Tanimoto, Shun Hirota
Indonesian Journal of Medical Chemistry and Bioinformatics
Background: Breast cancer is the most common type of cancer in women with a very high mortality rate. This cancer is caused by uncontrolled growth of breast cells. Treatments for this malignancy are surgery, chemotherapy, and radiotherapy, however those methods can cause adverse effects and quite expensive. Complementary and alternative medicines (CAMs) are also used to support those main treatments, one of them is herbal medicine. Hibiscus rosa-sinensis is known to have various phytochemical components with antioxidant, antibacterial, anticancer, and analgesic activities. This study is aimed to determine the phytochemical composition, antioxidant activity and cytotoxicity of Hibiscus rosa-sinensis extract towards …
Can The Discovery Of High-Impact Diagnostics Be Improved By Matching The Sampling Rate Of Clinical Diagnostics To The Frequency Domain Of Diagnostic Information?, Steven W Millward, Peng Wei, David Piwnica-Worms, Seth T Gammon
Can The Discovery Of High-Impact Diagnostics Be Improved By Matching The Sampling Rate Of Clinical Diagnostics To The Frequency Domain Of Diagnostic Information?, Steven W Millward, Peng Wei, David Piwnica-Worms, Seth T Gammon
Faculty, Staff and Student Publications
Over the past 30 years, academic and industrial research investigators have developed molecular reporters to visualize cell death in complex biological systems. In parallel, clinical researchers, chemists, biochemists, and molecular biologists have endeavored to translate these molecular tools into clinical imaging agents. Despite these efforts, there are no clinically approved imaging methodologies with which to image cell death consistently and quantitatively. One reason may reside in the intrinsic mismatch between the sampling frequency of translational molecular imaging and the biochemical kinetics that define cell death. Beyond cell death imaging, many active research programs are now attempting to create translational diagnostic …
Impacts Of Climate Change On Cannibalism And Disease Transmission In The Fall Armyworm, Kale Rougeau
Impacts Of Climate Change On Cannibalism And Disease Transmission In The Fall Armyworm, Kale Rougeau
LSU Master's Theses
Climate change may alter host-pathogen dynamics in terrestrial ecosystems due to rising global temperatures and carbon dioxide levels. Here, we examined cannibalism and disease transmission using the fall armyworm (Spodoptera frugiperda), an invasive agricultural pest, and its species-specific lethal baculovirus, Spodoptera frugiperda multiple nucleopolyhedrovirus (SfMNPV), under various potential challenges of climate change. We used three temperature treatments (cooler, optimal, warmer) based on the fall armyworm’s thermal performance curve to simulate a changing climate and four artificial diets with various protein-to-carbohydrate ratios (low, equal, high, standard) to manipulate resource quality from altered carbon dioxide levels. We found that higher …
Floating And Submerged Plants Of Utah: Pocket Field Guide, Kate Sinnott, Karin M. Kettenring
Floating And Submerged Plants Of Utah: Pocket Field Guide, Kate Sinnott, Karin M. Kettenring
All Current Publications
This is a field guide to identifying floating and submerged plants of Utah. We include a page for each species and also a dichotomous key at the end for the pondweeds. Submerged and floating plant species play critical roles in aquatic ecosystems. They provide habitat to aquatic organisms, improve water clarity by trapping sediment, and absorb excess nutrients from the water column, among other vital services. However, they have been threatened and degraded by pollution, land conversion, and introductions of harmful species. Identifying native and non-native plants is an important component of tackling this degradation and promoting the conservation and …
Building Climate Resilience Through Food Recovery, San Diego Regional Climate Collaborative, Alexander Pourfard, Aranza Ruvalcaba
Building Climate Resilience Through Food Recovery, San Diego Regional Climate Collaborative, Alexander Pourfard, Aranza Ruvalcaba
San Diego Regional Climate Collaborative
In an effort to combat GHG emissions from food waste, California passed Senate Bill 1383 (SB 1383) into law in 2016. The bill contains key provisions aimed at increasing edible food recovery. By rescuing food that would otherwise go to the landfill, California entities have been able to help save precious food and advance sustainable solutions to address climate change in their local communities. Since the food recovery requirements took effect in January of 2022, over 217,000 tons of unsold food have been recovered annually, providing more than 700 million meals to food-insecure Californians.
A Geospatial Livestock-Carrying Capacity Model (Glcc) In The Akmola Oblast, Kazakhstan, Jiaguo Qi, Zihan Lin, Mark A. Weltz, Kenneth Spaeth, Gulnaz Iskakova
A Geospatial Livestock-Carrying Capacity Model (Glcc) In The Akmola Oblast, Kazakhstan, Jiaguo Qi, Zihan Lin, Mark A. Weltz, Kenneth Spaeth, Gulnaz Iskakova
Biological, Geological, and Environmental Faculty Publications
Spatial disparities in rangeland conditions across Kazakhstan complicate field-based assessments of livestock-carrying capacity (LCC), a critical metric for the country's food security and economic planning. This study developed a geospatial livestock-carrying capacity (GLCC) modeling framework to quantify LCC spatio-temporal dynamics at the Oblast level, by integrating satellite-derived data on vegetation, water resources, and terrain with in situ measurements. By providing ground-truth observations and contextual detail, field-based measurements complement remote sensing data and help to validate estimates and improve the reliability of the GLCC model. The modeling framework was successfully applied and validated in a case study in the Akmola Oblast, …
Genetic Regulation Of Anthocyanin Biosynthesis In Flower Color In Gilia, Veronica Mosquera
Genetic Regulation Of Anthocyanin Biosynthesis In Flower Color In Gilia, Veronica Mosquera
Theses and Dissertations
Gilia was the model species in this research to study the genetic regulation of flower color. I generated an F2 population from a cross of two closely related leafy-stemmed Gilia: G. capitata with blue and G. yorkii with white flowers, to obtain the fertile F1, which was selfed. The F2 population showed a segregation ratio between pigmented versus white flowers 3:1, suggesting a single locus with a major effect on the regulation of flower color. Then, the G. yorkii genome was assembled and annotated to become the reference genome to genotype-by-sequencing (GBS) 189 F2 individuals. The Quantitative Trait Loci (QTL) …
Highly Targeted Metabolomics Coupled With Gene Expression Analysis By Rt–Qpcr Improves Beef Separation Based On Grass, Grain, Or Grape Supplemented Diet, Lucas Krusinski, Chloe Castanon, Rosalee S. Hellberg, Isabella C. F. Maciel, Muhammad Ahsin, Stephan Van Vliet, Jason E. Rowntree, Jennifer I. Fenton
Highly Targeted Metabolomics Coupled With Gene Expression Analysis By Rt–Qpcr Improves Beef Separation Based On Grass, Grain, Or Grape Supplemented Diet, Lucas Krusinski, Chloe Castanon, Rosalee S. Hellberg, Isabella C. F. Maciel, Muhammad Ahsin, Stephan Van Vliet, Jason E. Rowntree, Jennifer I. Fenton
Food Science Faculty Articles and Research
The objective of this study was to use a multi-omics (i.e., gene expression quantification, metabolomics, and fatty acid [FA] profiling) approach to separate and authenticate beef from three different dietary groups. In this 2-year study, Red Angus steers (n = 54) were randomly allocated to one of three treatments: (1) complex biodiverse pasture (GRASS), (2) total mixed ration (TMR) in feedlot (GRAIN), or (3) TMR in feedlot supplemented with 5% (dry matter) grapeseed extract for the last 30 days (GRAPE). FAs were measured by gas chromatography-mass spectrometry (GC–MS), secondary metabolites were identified using ultra-high-performance liquid chromatography tandem mass spectrometry …
Sustainable Forage Yield Improvement Through Perennial Grass–Legume Intercropping In Degraded Grasslands, Alina-Ștefania Stanciu
Sustainable Forage Yield Improvement Through Perennial Grass–Legume Intercropping In Degraded Grasslands, Alina-Ștefania Stanciu
Turkish Journal of Agriculture and Forestry
Grasslands constitute one of the largest terrestrial biomes, providing essential ecosystem services such as biodiversity preservation, food production, and climate change mitigation. Globally, the desertification and degradation of grasslands have been accelerated by intensified land use and climate change. It is crucial to conserve and restore grasslands to address climate and biodiversity challenges. However, due to their diverse nature and undervalued benefits for humans, grasslands have often been overlooked in terms of preservation, conservation, and restoration compared to forests. In sustainable agriculture, intercropping grasses with legumes can enhance crop nutritional quality, increase productivity, and impact soil microbiological activity, ultimately leading …
Silage Yield And Quality Of Different Grass Pea (Lathyrus Sativus L.) Genotypes, Murat Azak, Erdem Gülümser
Silage Yield And Quality Of Different Grass Pea (Lathyrus Sativus L.) Genotypes, Murat Azak, Erdem Gülümser
Turkish Journal of Agriculture and Forestry
This study aimed to determine the silage yield and quality of different 12 grass pea (Lathyrus sativus L.) genotypes (Gap Mavisi, İptaş, Karadağ, 1603, 2006, 2401, 4301, 4403, 5001, 6408, 6410, and S3). The trial was established in Bilecik’s ecological conditions in 2022 and 2023. It was carried out according to the randomized block design with four replications, and the plants were harvested at the full flowering stage. The harvested plants were chopped to 2 cm in size and ensiled in vacuum bags and left to ferment at 25 ± 2 °C for 45 days. The silage yield, pH, dry …
Digital Image Processing In Determining The Degree Of Turnip Yellows Virus Infection In Oilseed Rape, Alina-Ștefania Stanciu, Teodor Rusu, Alin Cristian Teușdea, Olimpia Smaranda Mintaș, Mihai Marcel Cărbunar, Cristian Oneț
Digital Image Processing In Determining The Degree Of Turnip Yellows Virus Infection In Oilseed Rape, Alina-Ștefania Stanciu, Teodor Rusu, Alin Cristian Teușdea, Olimpia Smaranda Mintaș, Mihai Marcel Cărbunar, Cristian Oneț
Turkish Journal of Agriculture and Forestry
In agricultural crops, leaves play crucial roles in plant physiology, providing information on both the quantity and quality of future production. They also serve as indicators for diagnosing foliar diseases. Detecting plant diseases through image reading and computer vision in a specific format allows for both quantitative and qualitative studies, which is a key step in diagnosing diseases using images of leaves exhibiting symptoms specific to a pathogen. In this study, we present an approach that integrates digital image processing to assess the extent of turnip yellows virus (genus Polerovirus, family Solemoviridae) infection in oilseed rape. This study focuses on …
From Ancient Wisdom To Modern Medicine: The Cultural And Therapeutic Significance Of Ficus Carica L. (Moraceae) Extracts In Colorectal Cancer Treatment, Esra Hacimüftüoğlu, Azizeh Shadidizaji, Kağan Tolga Ci̇ni̇sli̇, Songül Karakaya
From Ancient Wisdom To Modern Medicine: The Cultural And Therapeutic Significance Of Ficus Carica L. (Moraceae) Extracts In Colorectal Cancer Treatment, Esra Hacimüftüoğlu, Azizeh Shadidizaji, Kağan Tolga Ci̇ni̇sli̇, Songül Karakaya
Turkish Journal of Agriculture and Forestry
Figs, mentioned in the Torah, the Bible, and the Quran, are of historical and cultural significance and have been used for medical treatment, prompting extensive research. Colorectal cancer (CRC), the second leading cause of cancer-related death worldwide, is expected to significantly increase in terms of mortality rates by 2035, with its progression closely linked to inflammatory processes. Cyclooxygenase 2 (COX-2), an enzyme encoded by the Ptgs2 gene, plays a key role in these processes by converting arachidonic acid into prostaglandin E2 (PGE2), a mediator of inflammation. In the present study, the potential of natural antiinflammatory compounds, specifically fumaric acid and …
Early Survival And Growth Of Haloxylon Ammodendron Seedlings Under Irrigation In Arid Southern Tajikistan, Jieun Ahn, Gaeun Kim, Heejae Jo, Jieun Park, Youngjin Lee, Woo-Kyun Lee, Asia Khamzina, Yowhan Son
Early Survival And Growth Of Haloxylon Ammodendron Seedlings Under Irrigation In Arid Southern Tajikistan, Jieun Ahn, Gaeun Kim, Heejae Jo, Jieun Park, Youngjin Lee, Woo-Kyun Lee, Asia Khamzina, Yowhan Son
Turkish Journal of Agriculture and Forestry
Understanding plant drought responses is crucial for effective afforestation in drylands. This study aimed to investigate the effects of irrigation (31.25 mm seedling–1 every 45 days) on the early survival and growth of 3-month-old Haloxylon ammodendron seedlings at an afforestation site established in Tajikistan in 2021. In July 2022 and June 2023, surveys were conducted to compare seedling survival rates, height, root collar diameter (RCD), stem volume per unit area, and height-to-RCD ratio between irrigation (IR) and nonirrigation (NIR) treatments. The IR treatment increased survival rates in 2022 but not in 2023. By 2023, the IR treatment had increased the …
Yellow Stingray (Urobatis Jamaicensis) Jaw, Marissa Rosas, David Kerstetter
Yellow Stingray (Urobatis Jamaicensis) Jaw, Marissa Rosas, David Kerstetter
All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series
No abstract provided.
Adapting To Climate Change In Semiarid Regions Via Conservation Measures: Climate-Smart Crop Rotations Of Food Legumes In Cool Seasons, Velibor Spalevic, Mohsen Janmohammadi, Naser Sabaghnia, Shuraik Kader
Adapting To Climate Change In Semiarid Regions Via Conservation Measures: Climate-Smart Crop Rotations Of Food Legumes In Cool Seasons, Velibor Spalevic, Mohsen Janmohammadi, Naser Sabaghnia, Shuraik Kader
Turkish Journal of Agriculture and Forestry
The high potential of evapotranspiration, unsuitable soil conditions, irregular distribution of rainfall, and ineffective techniques of soil moisture conservation are among the limitations of semiarid regions of Central and West Asia and North Africa (CWANA), and they have intensified during recent decades with climate change. CWANA’s agroecosystems are fragile and highly vulnerable to the consequences of global warming and aggravation of water scarcity, and need to redefine agroclimatic zoning. Winter cereals are the predominant crops in the region of CWANA. The highest amount of cultivation is allocated to societies with dominant rainfed agriculture, which is often not economically profitable. The …
Postharvest Application Of 1-Methylcyclopropene And Modified Atmosphere Packaging Extends Shelf Life And Maintains Eating Quality Of Mango Fruit Cv. Sufaid Chaunsa, Hafiz Muhammad Usman, Sajid Hussain, Raheel Anwar, Ahmad Sattar Khan, Aman Ullah Malik, Muhammad Moaaz Ali, Khurram Ziaf, Arooba Abbas
Postharvest Application Of 1-Methylcyclopropene And Modified Atmosphere Packaging Extends Shelf Life And Maintains Eating Quality Of Mango Fruit Cv. Sufaid Chaunsa, Hafiz Muhammad Usman, Sajid Hussain, Raheel Anwar, Ahmad Sattar Khan, Aman Ullah Malik, Muhammad Moaaz Ali, Khurram Ziaf, Arooba Abbas
Turkish Journal of Agriculture and Forestry
The mango (Mangifera indica L.) fruit is globally relished for its sweet taste, unique aromatic profile, and enriched nutritional value. However, its short postharvest life is a serious challenge for export to long-distance markets. 1-Methylcyclopropene (1-MCP) is an ethylene inhibitor known to delay ripening in many fruits, including mango. However, comparative research suggesting an appropriate method to treat mangoes with 1-MCP is limited. In this study, mango fruit cv. Sufaid Chaunsa were fumigated with 0.25 ppm 1-MCP or treated aqueously with 1.2 ppm 1-MCP for 5 min and then packed in modified atmosphere packaging (MAP). The control fruits were not …
Effects Of Cooking Oil And Bitter Gourd On Obesity Development In C57bl/6j Mice, Justin Talmadge Mcguire
Effects Of Cooking Oil And Bitter Gourd On Obesity Development In C57bl/6j Mice, Justin Talmadge Mcguire
Honors Theses
This study examined the use of different oils in the development of obesity and type 2 diabetes mellitus (T2DM), with bitter gourd incorporated into unhealthy diets to assess its effects. A total of 72 mice were divided into six groups. Two of these groups were gavaged with an aqueous solution of bitter gourd, with one group additionally receiving corn oil and the other receiving lard. The four groups that did not receive bitter gourd were each fed a different diet containing either corn oil, lard, canola oil, or olive oil. Measurements of weight, food intake, water consumption, blood glucose levels, …
Effects Of Pharmacologic And Genetic Manipulation Of Gaba-A Receptors On Network Activity, Peter Michael Lambert
Effects Of Pharmacologic And Genetic Manipulation Of Gaba-A Receptors On Network Activity, Peter Michael Lambert
Arts & Sciences Graduate Student Theses and Dissertations
GABAA receptors (GABAARs) are the primary inhibitory neurotransmitter receptors in the central nervous system. A rich diversity of receptor subtypes are produced by the combination of various GABA receptor subunits into a heteropentameric chloride channel. Inhibitory signaling through GABAARs occurs on timescales ranging from fast synaptic events lasting milliseconds to tonically active receptors providing standing inhibitory tone. GABAARs are modulated by many clinically important drugs including anesthetic, hypnotic, anxiolytic, and antidepressant agents. Of note, GABAARs are modulated by neurosteroids, which have recently been developed as novel therapeutic agents for psychiatric disease. The synchronized activation of GABAARs through coordinated activity of …
Roles Of Cpsa And Slamf1 In The Innate Immune Response To Mycobacterium Tuberculosis, Steven Grigsby
Roles Of Cpsa And Slamf1 In The Innate Immune Response To Mycobacterium Tuberculosis, Steven Grigsby
Arts & Sciences Graduate Student Theses and Dissertations
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), possesses an arsenal of virulence factors to evade host immunity. Not only is Mtb able to evade innate immunity, but adaptive immunity also often fails to adequately control Mtb infection. A mechanistic understanding of how Mtb establishes infection and evades immunity is critical to the development of a protective vaccine and novel therapeutics. The Mtb protein CpsA protects Mtb against the host NADPH oxidase and LC3-asociated phagocytosis of the innate immune system. Consequently, a ΔcpsA mutant is initially attenuated in vivo but eventually reaches the same bacterial burden in the lungs …
Archaeozoological Remains From Ramla, Moshe Sade
Early Islamic Remains At ‘Opher Park, Ramla, Raz Kletter
Early Islamic Remains At ‘Opher Park, Ramla, Raz Kletter
'Atiqot
No abstract provided.
Fish Remains From ‘En Gedi, Omri Lernau
Neuronal Cftr: A Study Of Subcellular Localization And Interactions With Implications For A Role In Synaptic Transmission, Brandon J. Leviskas
Neuronal Cftr: A Study Of Subcellular Localization And Interactions With Implications For A Role In Synaptic Transmission, Brandon J. Leviskas
LSU Doctoral Dissertations
Protein-protein interactions vary among cell types and the localization of these interactions help to define protein function. The function of cystic fibrosis transmembrane conductance regulator (CFTR) is well established in the context of epithelial tissue due to the debilitating effects of its mutations that cause the disease cystic fibrosis. While in neurons a role has been established in our lab for CFTR in the regulation of cytosolic Cl- in retinal amacrine cells (ACs). This research sets out to learn if CFTR has a synaptic role. Exploring this potential role, localization of CFTR was examined using fluorescent and immunogold labeled transmission …
Scorpions Of The Horn Of Africa (Arachnida, Scorpiones). Part Xxxvii. The Genus Hemiscorpius (Hemiscorpiidae), František Kovařík, Hassan Sh A. Elmi, František Šťáhlavský
Scorpions Of The Horn Of Africa (Arachnida, Scorpiones). Part Xxxvii. The Genus Hemiscorpius (Hemiscorpiidae), František Kovařík, Hassan Sh A. Elmi, František Šťáhlavský
Euscorpius
Occurrence of the rare in the Horn of Africa genus Hemiscorpius Peters, 1861 (Scorpiones: Hemiscorpiidae) is summarized, including a distribution map. A male of Hemiscorpius lipsae Kovařík & Lowe, 2022 from Djibouti is described for the first time. A new species Hemiscorpius huluul sp. n. from Somaliland is described, fully complemented with color photographs.
Research Week 2025 Poster, Michael Schueth
Effects Of Citric Acid, Synbiotic, And Probiotic Supplementation Through Drinking Water On Growth Performance, Carcass Yield, And Blood Biochemistry Of Broiler Chickens, Shahadot Hossain, Biswajit Kumar Biswas, Subir Das, Faija Sadia Pory, Rabin Raut, Fatima Yeasmin, Sharif Uddin Khan, Prantho Malakar Dipta, Sabbir Alom Shuvo, Tahera Yeasmin, Raihanul Hoque
Effects Of Citric Acid, Synbiotic, And Probiotic Supplementation Through Drinking Water On Growth Performance, Carcass Yield, And Blood Biochemistry Of Broiler Chickens, Shahadot Hossain, Biswajit Kumar Biswas, Subir Das, Faija Sadia Pory, Rabin Raut, Fatima Yeasmin, Sharif Uddin Khan, Prantho Malakar Dipta, Sabbir Alom Shuvo, Tahera Yeasmin, Raihanul Hoque
Food and Animal Sciences Faculty Research
No abstract provided.
Restoring Exotic Cool-Season Grass Dominated Landscapes With Clethodim And Glyphosate, Eleanor J. Muzzy, Joshua D. Wiese, Abraham J. Kanz
Restoring Exotic Cool-Season Grass Dominated Landscapes With Clethodim And Glyphosate, Eleanor J. Muzzy, Joshua D. Wiese, Abraham J. Kanz
Transactions of the Nebraska Academy of Sciences and Affiliated Societies
A major threat to grasslands around the world is the spread of exotic cool-season grasses (ECSG). ECSG dominate vegetative communities and degrade critical habitats. One of the most common methods to treat ECSG is herbicide. To compare how the widely-used, non-specific herbicide glyphosate compared to the grass-specific herbicide clethodim, we conducted a fall spray in November 2023 at two different sites located in the Central Platte River Valley of Nebraska. The following June, we used a modified Daubenmire frame sampling method to gather data on relative cover, species richness, and community composition. After analysis, glyphosate appeared to be more effective …
Enriched Pathways In Gut Microbiome Predict Response To Immune Checkpoint Inhibitor Treatment Across Demographic Regions And Various Cancer Types, Xunhui Cai, Jennifer Y Cho, Lijun Chen, Yufeng Liu, Fenghu Ji, Katia Salgado, Siyi Ge, Dehua Yang, Hui Yu, Jianbo Shao, P Andrew Futreal, Boris Sepesi, Don Gibbons, Yaobing Chen, Guoping Wang, Chao Cheng, Meng Wu, Jianjun Zhang, Ansel Hsiao, Tian Xia
Enriched Pathways In Gut Microbiome Predict Response To Immune Checkpoint Inhibitor Treatment Across Demographic Regions And Various Cancer Types, Xunhui Cai, Jennifer Y Cho, Lijun Chen, Yufeng Liu, Fenghu Ji, Katia Salgado, Siyi Ge, Dehua Yang, Hui Yu, Jianbo Shao, P Andrew Futreal, Boris Sepesi, Don Gibbons, Yaobing Chen, Guoping Wang, Chao Cheng, Meng Wu, Jianjun Zhang, Ansel Hsiao, Tian Xia
Faculty, Staff and Student Publications
Understanding the effect of gut microbiota function on immune checkpoint inhibitor (ICI) responses is urgently needed. Here, we integrated 821 fecal metagenomes from 12 datasets to identify differentially abundant genes and construct random forest models to predict ICI response. Gene markers demonstrated excellent predictive performance, with an average area under the curve (AUC) of 0.810. Pathway analyses revealed that quorum sensing (QS), ABC transporters, flagellar assembly, and amino acid biosynthesis pathways were enriched between responders (R) and non-responders (NRs) across 12 datasets. Furthermore,
Rnase1-Driven Alk-Activation Is An Oncogenic Driver And Therapeutic Target In Non-Small Cell Lung Cancer, Zhengyu Zha, Chunxiao Liu, Meisi Yan, Cong Chen, Cheng Yu, Yaohui Chen, Chenhao Zhou, Lu Li, Yi-Chuan Li, Hiro Yamaguchi, Leiguang Ye, Tong Liu, Ying-Nai Wang, Heng-Huan Lee, Wen-Hao Yang, Li-Chuan Chan, Baozhen Ke, Jennifer L Hsu, Lieming Ding, Dong Ji, Peng Pan, Yiran Meng, Yue Pu, Lunxu Liu, Mien-Chie Hung
Rnase1-Driven Alk-Activation Is An Oncogenic Driver And Therapeutic Target In Non-Small Cell Lung Cancer, Zhengyu Zha, Chunxiao Liu, Meisi Yan, Cong Chen, Cheng Yu, Yaohui Chen, Chenhao Zhou, Lu Li, Yi-Chuan Li, Hiro Yamaguchi, Leiguang Ye, Tong Liu, Ying-Nai Wang, Heng-Huan Lee, Wen-Hao Yang, Li-Chuan Chan, Baozhen Ke, Jennifer L Hsu, Lieming Ding, Dong Ji, Peng Pan, Yiran Meng, Yue Pu, Lunxu Liu, Mien-Chie Hung
Faculty, Staff and Student Publications
Targeted therapy has achieved significant success in the treatment of non-small cell lung cancer (NSCLC), particularly in patients harboring common oncogenic driver mutations such as EGFR, KRAS, and ALK rearrangement. However, ~35-50% of NSCLC patients without tyrosine kinase mutation or rearrangement (non-mutated) cannot benefit from these targeted treatments, highlighting the urgent need for novel therapeutic strategies for this patient population. In this study, we report a non-canonical role of human secretory ribonuclease 1 (RNase1), which binds to and activates wild-type ALK in lung cancer cells, thereby triggering its downstream signaling pathway. RNase1-driven ALK-activation (RDAA) cells exhibit enhanced cell proliferation, migration, …