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Identifying Land Snails, Department Of Primary Industries And Regional Development, Western Australia Oct 2025

Identifying Land Snails, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity factsheets

Snails can be voracious eaters, destroying leafy vegetables, cereal crops, pasture grasses and some native plants. From time to time, exotic snails are intercepted in cargo, machinery, vehicles and packaging and then destroyed.

Snail species may be native or already established in Westen Australia; however, your reports will help detect exotic snails early and prevent them from invading gardens, agriculture and the environment.


Cattle Funding Scheme 2023-24 Annual Report, Department Of Primary Industries And Regional Development, Western Australia Oct 2025

Cattle Funding Scheme 2023-24 Annual Report, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity published reports

I am pleased to present the 2023-24 annual report for the Cattle Industry Funding Scheme (Cattle IFS) to our participants, key stakeholders in the Western Australian (WA) cattle industry, and the Minister for Agriculture and Food. This financial year has brought its share of challenges to the WA cattle industry including domestic and global markets, dry weather conditions and high biosecurity concerns. With Foot-and-mouth disease (FMD) and Lumpy Skin Disease (LSD) detected in Indonesia, biosecurity threats remain ever-present. As a result, maintaining the health of our herd in WA continues to be our top priority. The Cattle IFS continues to …


The Brain-Derived Neurotrophic Factor (Bdnf) And Its Importance To Organism Survival And Development, Christopher Monnett Smith Oct 2025

The Brain-Derived Neurotrophic Factor (Bdnf) And Its Importance To Organism Survival And Development, Christopher Monnett Smith

Holster Scholar Projects

Brain-Derived Neurotrophic Factor (BDNF) has been the subject of numerous studies regarding the functioning of the brain in relation to topics such as neural plasticity and neural survival. However, BDNF has also been implicated in the induction of changes not only in neural tissue but multiple other tissue types across the human body. The aim of this literature review is to provide a comprehensive, yet brief, overview of BDNF’s influence on the functioning of the nervous, cardiovascular, respiratory, muscular, and immune systems.


Does Increasing Canopy Liana Density Decrease The Tropical Forest Carbon Sink?, Stefan A. Schnitzer, David M. Defilippis Oct 2025

Does Increasing Canopy Liana Density Decrease The Tropical Forest Carbon Sink?, Stefan A. Schnitzer, David M. Defilippis

Biological Sciences Faculty Research and Publications

The ongoing decline in the American tropical forest carbon sink has serious ramifications for atmospheric carbon levels and global climate change. Increasing liana abundance may explain the decaying carbon sink because lianas reduce canopy tree growth and survival, which limits forest carbon storage. However, canopy lianas, not solely understory lianas, would have to be increasing for this hypothesis to be credible because canopy lianas compete especially intensely with canopy trees. We examined the change in canopy lianas over 10 years on Barro Colorado Island (BCI), Panama to test two main hypotheses. (1) Canopy lianas are increasing on BCI. (2) Increasing …


Valid And Accepted Novel Bacterial Taxa Isolated From Domestic Companion And Agricultural Animals Described In 2024, Sara D. Lawhon, Claire R. Burbick, Trinity Krueger, Elena Ruiz-Reyes, Ayden Wisney-Leonard, Mallory Lenmark, Erik Munson Oct 2025

Valid And Accepted Novel Bacterial Taxa Isolated From Domestic Companion And Agricultural Animals Described In 2024, Sara D. Lawhon, Claire R. Burbick, Trinity Krueger, Elena Ruiz-Reyes, Ayden Wisney-Leonard, Mallory Lenmark, Erik Munson

Clinical Lab Sciences Faculty Research and Publications

Recognizing and updating bacterial names is key to communication between the veterinary clinical microbiology laboratory, veterinarians, and clients. Moraxella oculi sp. nov., distinct from Moraxella bovis and Moraxella bovoculi, was isolated from a cow with infectious bovine keratoconjunctivitis. Several respiratory pathogens were recognized, including Neisseria leonii sp. nov. described from rabbits, Mannheimia indoligenes sp. nov. described from cattle in Europe, and Moraxella haemolytica sp. nov. described from a goat in China. Stenotrophomonas forensis sp. nov. is a novel designation within the Stenotrophomonas maltophilia complex associated with isolates derived from horses. New additions to the Campylobacter genus included Campylobacter californiensis …


Chemistry And Biochemistry Affiliated Publications: Snapshot Of The Research Publications 2019-2024., Jeremy J. Smith, Lutishoor Salisbury Oct 2025

Chemistry And Biochemistry Affiliated Publications: Snapshot Of The Research Publications 2019-2024., Jeremy J. Smith, Lutishoor Salisbury

University Libraries Faculty Publications and Presentations

This report highlights the chemistry and biochemistry faculty publications for the period 2019-2024. It includes tables identifying the types of publications, the characteristics of the authors, inter-departmental and external cooperation, summary of the citations of the publications, and the JCR ranking of the journals in which they published.


Growing South Dakota (Fall 2025), College Of Agriculture, Food And Environmental Sciences Oct 2025

Growing South Dakota (Fall 2025), College Of Agriculture, Food And Environmental Sciences

Growing South Dakota (Publication of the College of Agriculture, Food and Environmental Sciences)

[Page] 2 Mesonet at SDState: A benefit to every South Dakotan
[Page] 6 Governor’s Ag Ambassador — Glenn Muller
[Page] 8 Precision agriculture cooperative agreement signed with University of Debrecen
[Page] 10 Students experience international agriculture, culture in Vietnam, New Zealand
[Page] 12 Legen-dairy! SDSU students claim national judging awards
[Page] 13 SDSU Rodeo Team continues storied rodeo tradition at nationals
[Page] 14 SDSU wheat breeders helping feed the world
[Page] 20 SDSU drone holds promise for soil, leaf sampling
[Page] 22 Don't be a fish out of water
[Page] 24 A passion for academic advising
[Page] 25 One takeaway …


Hungry Minds: Analyzing The Impact Of Food Insecurity And Food Assistance Programs On Neurocognitive Development And Childhood Mental Health, Kayla A. Davenport Oct 2025

Hungry Minds: Analyzing The Impact Of Food Insecurity And Food Assistance Programs On Neurocognitive Development And Childhood Mental Health, Kayla A. Davenport

Senior Theses

Introduction: Food insecurity affects millions of children in the United States and is increasingly recognized as a significant risk factor for poor nutritional intake and adverse health outcomes. However, less is known about how the experience of food insecurity disrupts healthy development and well-being, particularly among American youth. This thesis had two aims: (1) to examine the relationship between household food insecurity and children’s neurocognitive and mental health outcomes and (2) to evaluate how major food assistance programs address, or fail to address, these developmental risks.

Methods: This thesis uses a mixed-methods approach, integrating a narrative literature review, a cross-sectional …


Cervical And Tumor-Associated Microbiomes In Botswana Women With And Without Hiv With Carcinoma Of The Cervix Before And After Definitive Chemoradiation, Travis T Sims, Kyoko Yoshida-Court, Molly B El Alam, Pleasure Ramatlho, Rebecca Ketlametswe, Matthew S Ning, Erle S Robertson, Kathleen M Schmeler, Lauren E Colbert, Ann H Klopp, Surbhi Grover Oct 2025

Cervical And Tumor-Associated Microbiomes In Botswana Women With And Without Hiv With Carcinoma Of The Cervix Before And After Definitive Chemoradiation, Travis T Sims, Kyoko Yoshida-Court, Molly B El Alam, Pleasure Ramatlho, Rebecca Ketlametswe, Matthew S Ning, Erle S Robertson, Kathleen M Schmeler, Lauren E Colbert, Ann H Klopp, Surbhi Grover

Faculty, Staff and Student Publications

Purpose: Cervical cancer remains a significant public health concern globally and particularly in sub-Saharan Africa, where high rates of HIV infection exacerbate cervical cancer incidence. Understanding the cervical microbiome and its role in cancer progression is essential, especially in regions where both cervical cancer incidence and HIV prevalence are high. This study aimed to characterize the cervical microbiome in women living with HIV (WLWH) and HIV-negative women with squamous cell carcinoma of the cervix in Botswana, compare the microbiome between before and after chemoradiation therapy (CRT) in WLWH, and assess the prognostic value of specific microbial taxa for overall survival …


Site-Specific Drug Release Of Monomethyl Fumarate To Treat Oxidative Stress Disorders, Thomas D Avery, Jiahe Li, Dion J L Turner, Mohd S U Rasheed, Fisher R Cherry, Damian L Stachura, Fátima Rivera-Escalera, David M Ruiz, Michael J Lacagnina, Caitlyn M Gaffney, Clarissa Aguilar, Jingxian Yu, Yang Wang, Huan Xie, Dong Liang, Andrew J Shepherd, Andrew D Abell, Peter M Grace Oct 2025

Site-Specific Drug Release Of Monomethyl Fumarate To Treat Oxidative Stress Disorders, Thomas D Avery, Jiahe Li, Dion J L Turner, Mohd S U Rasheed, Fisher R Cherry, Damian L Stachura, Fátima Rivera-Escalera, David M Ruiz, Michael J Lacagnina, Caitlyn M Gaffney, Clarissa Aguilar, Jingxian Yu, Yang Wang, Huan Xie, Dong Liang, Andrew J Shepherd, Andrew D Abell, Peter M Grace

Faculty, Staff and Student Publications

Treatment of diseases of oxidative stress through activation of the antioxidant nuclear factor E2-related factor 2 (NRF2) is limited by systemic side effects. We chemically functionalize the NRF2 activator monomethyl fumarate to require Baeyer-Villiger oxidation for release of the active drug at sites of oxidative stress. This prodrug reverses chronic pain in mice with reduced side effects and could be applied to other disorders of oxidative stress.


First Experience With Third-Party Validations: A Robust Calibration And Qa Procedure For Proton Flash Delivery, Chih-Chiang Chang, Balaji Selvaraj, Xingyi Zhao, Jacob Rembish, Paige A Taylor, Alexander Bookbinder, Chingyun Cheng, J Isabelle Choi, Charles B Simone, Haibo Lin, Minglei Kang Oct 2025

First Experience With Third-Party Validations: A Robust Calibration And Qa Procedure For Proton Flash Delivery, Chih-Chiang Chang, Balaji Selvaraj, Xingyi Zhao, Jacob Rembish, Paige A Taylor, Alexander Bookbinder, Chingyun Cheng, J Isabelle Choi, Charles B Simone, Haibo Lin, Minglei Kang

Faculty, Staff and Student Publications

Background: Proton FLASH radiotherapy, delivering ultra-high dose rates, shows promise in reducing normal tissue toxicity while maintaining tumor control. However, accurate dosimetry and quality assurance (QA) for FLASH remain challenging due to the extreme dose rates involved. Developing reliable calibration and QA procedures is crucial for advancing FLASH towards clinical implementation.

Purpose: To present an effective routine calibration and QA procedure for proton FLASH delivery to ensure high-quality dosimetry performance for preclinical and clinical delivery.

Methods: A high temporospatial resolution strip ionization chamber array (SICA) detector was mounted to the treatment nozzle, which was calibrated using an Advanced Markus ion …


Mapping Cardiac Electrical Abnormalities In Rodents, Ashish Kapoor, Peter A Doris Oct 2025

Mapping Cardiac Electrical Abnormalities In Rodents, Ashish Kapoor, Peter A Doris

Faculty, Staff and Student Publications

No abstract provided.


Cancer-Associated Fibroblasts As Mediators Of Tissue Microenvironment Remodeling In Cancer, Fernanda G Kugeratski, Emily J Kay, Sara Zanivan Oct 2025

Cancer-Associated Fibroblasts As Mediators Of Tissue Microenvironment Remodeling In Cancer, Fernanda G Kugeratski, Emily J Kay, Sara Zanivan

Faculty, Staff and Student Publications

Cancer-associated fibroblasts (CAFs) are a multifunctional cell population of solid tumors that substantially remodel the tumor microenvironment (TME). The combination of single-cell and spatial technologies with elegant mouse models and analysis of patient samples is enabling unprecedented advances in the characterization of CAF origins, heterogeneity, and functions within the TME. As such, the field is now evolving to delineate tissue-specific subpopulations of CAFs, their markers, and the biological context in which each subset presents with a tumor-promoting or a tumor-restraining function. In this timely review, we discuss recent advances in CAF biology in the context of emerging areas of interest …


Cancer-Induced Nerve Injury Promotes Resistance To Anti-Pd-1 Therapy, Erez N Baruch, Frederico O Gleber-Netto, Priyadharsini Nagarajan, Xiayu Rao, Shamima Akhter, Tuany Eichwald, Tongxin Xie, Mohammad Balood, Adebayo Adewale, Shorook Naara, Hinduja N Sathishkumar, Shajedul Islam, William Mccarthy, Brandi J Mattson, Renata Ferrarotto, Michael K Wong, Michael A Davies, Sonali Jindal, Sreyashi Basu, Karine Roversi, Amin Reza Nikpoor, Maryam Ahmadi, Ali Ahmadi, Catherine Harwood, Irene Leigh, Dennis Gong, Paulino Tallón De Lara, Derrick L Tao, Tara M Davidson, Nadim J Ajami, Andrew Futreal, Kunal Rai, Veena Kochat, Micah Castillo, Preethi Gunaratne, Ryan P Goepfert, Sharia D Hernandez, Nikhil I Khushalani, Jing Wang, Stephanie S Watowich, George A Calin, Michael R Migden, Mona Yuan, Naijiang Liu, Yi Ye, William L Hwang, Paola D Vermeer, Nisha J D'Silva, Yuri L Bunimovich, Dan Yaniv, Jared K Burks, Javier Gomez, Patrick M Dougherty, Kenneth Y Tsai, James P Allison, Padmanee Sharma, Jennifer A Wargo, Jeffrey N Myers, Sebastien Talbot, Neil D Gross, Moran Amit Oct 2025

Cancer-Induced Nerve Injury Promotes Resistance To Anti-Pd-1 Therapy, Erez N Baruch, Frederico O Gleber-Netto, Priyadharsini Nagarajan, Xiayu Rao, Shamima Akhter, Tuany Eichwald, Tongxin Xie, Mohammad Balood, Adebayo Adewale, Shorook Naara, Hinduja N Sathishkumar, Shajedul Islam, William Mccarthy, Brandi J Mattson, Renata Ferrarotto, Michael K Wong, Michael A Davies, Sonali Jindal, Sreyashi Basu, Karine Roversi, Amin Reza Nikpoor, Maryam Ahmadi, Ali Ahmadi, Catherine Harwood, Irene Leigh, Dennis Gong, Paulino Tallón De Lara, Derrick L Tao, Tara M Davidson, Nadim J Ajami, Andrew Futreal, Kunal Rai, Veena Kochat, Micah Castillo, Preethi Gunaratne, Ryan P Goepfert, Sharia D Hernandez, Nikhil I Khushalani, Jing Wang, Stephanie S Watowich, George A Calin, Michael R Migden, Mona Yuan, Naijiang Liu, Yi Ye, William L Hwang, Paola D Vermeer, Nisha J D'Silva, Yuri L Bunimovich, Dan Yaniv, Jared K Burks, Javier Gomez, Patrick M Dougherty, Kenneth Y Tsai, James P Allison, Padmanee Sharma, Jennifer A Wargo, Jeffrey N Myers, Sebastien Talbot, Neil D Gross, Moran Amit

Faculty, Staff and Student Publications

Perineural invasion (PNI) is a well-established factor of poor prognosis in multiple cancer types1, yet its mechanism remains unclear. Here we provide clinical and mechanistic insights into the role of PNI and cancer-induced nerve injury (CINI) in resistance to anti-PD-1 therapy. Our study demonstrates that PNI and CINI of tumour-associated nerves are associated with poor response to anti-PD-1 therapy among patients with cutaneous squamous cell carcinoma, melanoma and gastric cancer. Electron microscopy and electrical conduction analyses reveal that cancer cells degrade the nerve fibre myelin sheets. The injured neurons respond by autonomously initiating IL-6- and type I interferon-mediated …


Design And Development Of An Intervention To Improve The Quality And Safety Of Pediatric Dental Sedation: A Human-Centered Design Approach, Kawtar Zouaidi, Jan Yeager, Suhasini Bangar, Sayali Tungare, Urvi Mehta, Janelle Urata, Alfa-Ibrahim Yansane, Thomas Tanbonliong, Jungsoo Kim, Emily Sedlock, Krishna Kumar Kookal, Yan Xiao, Tokede Oluwabunmi, Heiko Spallek, Amy Franklin, Gregory W Olson, Joel White, Elsbeth Kalenderian, Muhammad F Walji Oct 2025

Design And Development Of An Intervention To Improve The Quality And Safety Of Pediatric Dental Sedation: A Human-Centered Design Approach, Kawtar Zouaidi, Jan Yeager, Suhasini Bangar, Sayali Tungare, Urvi Mehta, Janelle Urata, Alfa-Ibrahim Yansane, Thomas Tanbonliong, Jungsoo Kim, Emily Sedlock, Krishna Kumar Kookal, Yan Xiao, Tokede Oluwabunmi, Heiko Spallek, Amy Franklin, Gregory W Olson, Joel White, Elsbeth Kalenderian, Muhammad F Walji

Faculty, Staff and Student Publications

Background: There are gaps in understanding the experiences of children, parents, and providers during dental conscious sedation. This study aimed to capture and analyze these experiences to identify opportunities for improvement and enhance the quality and safety of pediatric dental conscious sedation.

Methods: A human-centered design approach was used to examine the conscious sedation experience in 2 US advanced education pediatric dental clinics. Researchers conducted field observations, interviews with providers and parents, and providers focus groups to explore experiential factors. Data were transcribed and analyzed using content thematic analysis. Insights from the data were used to explore and generate new …


Exudation Entomology, John Buchanan Oct 2025

Exudation Entomology, John Buchanan

Department of Entomology: Distance Master of Science Projects

My master's project is exudation entomology. I propose a new area of entomology that will renew and reshape the science, answer questions that have been explored, and open new questions that have yet to be asked.

Exudation entomology is the study of exudates from arthropods. This includes (but is not limited to) honey, saliva, silk, secretions, venom, pheromones, paper, wax, and more. Other properties, such as bioluminescence, sounds, and odors, are also included. Exudation entomology will explore the chemical makeup of exudates, the anatomical mechanisms for how the arthropod produces the exudate, why the exudate is essential for arthropods and …


Flies: Nature’S Hidden Helpers, A Science Literacy Project Exploring Beneficial And Pest Insects, Natalie Johnston Oct 2025

Flies: Nature’S Hidden Helpers, A Science Literacy Project Exploring Beneficial And Pest Insects, Natalie Johnston

Department of Entomology: Distance Master of Science Projects

A science literacy project for elementary learners exploring beneficial and pest insects with a focus on flies, nature's hidden helpers.

This project demonstrates that science literacy can be cultivated through experiential and interdisciplinary teaching. Future developments could include digital tools for compost monitoring, citizen science participation, or expanded studies of other decomposer species. Cross-curricular collaboration with language arts and art education can further strengthen the integration of creativity and evidence-based reasoning.

Ultimately, this work reaffirms that even small organisms—like flies—can inspire big learning outcomes. By integrating science literacy with sustainability education, we prepare students to think critically about ecological relationships …


Suturing Education For Athletic Trainers: An Evidence-To-Practice Review, Morgan K. Webb, Brett T. Heim, Allyson E. Ritchey, Kenya Moore, Zachary K. Winkelmann Oct 2025

Suturing Education For Athletic Trainers: An Evidence-To-Practice Review, Morgan K. Webb, Brett T. Heim, Allyson E. Ritchey, Kenya Moore, Zachary K. Winkelmann

Clinical Practice in Athletic Training

Teaching suturing skills to medical students is a critical component of their education. Implementing suturing into a comprehensive framework is developed from how professors teach the skill. Suturing is a required skill by the General Medical Council that all medical students must have, and how it is being introduced to new students is changing. This review aimed to summarize different educational interventions and determine the most efficient and cost-effective way to teach future suturing skills. The original systematic review included 25 articles in the final data synthesis. Fourteen studies were randomized control trials, six were quasi-experimental, and five were observational. …


77 | Khirbat ‘Amra: A Rural Site From The Hellenistic To Early Islamic Periods In The BeʼEr Sheva‘ Valley, Itamar Taxel, Noé D. Michael Oct 2025

77 | Khirbat ‘Amra: A Rural Site From The Hellenistic To Early Islamic Periods In The BeʼEr Sheva‘ Valley, Itamar Taxel, Noé D. Michael

IAA Reports—Monograph Series of the Israel Antiquities Authority

This volume constitutes the final report of the large-scale salvage excavations directed by Gil Tahal on behalf of the IAA in 1993–1994 at the site of Khirbat ‘Amra, in the north-central area of the Be’er Sheva‛ Valley. The excavations revealed architectural remains and finds dated mainly to the Hellenistic until the Early Islamic periods, in addition to scantier remains or isolated finds from the Chalcolithic period, the Iron Age II and the Ottoman period. Khirbat ‘Amra is one of the largest multiperiod sites in the Be’er Sheva‛ Valley, specifically in the Byzantine and Early Islamic periods. Furthermore, Tahal’s excavations were …


Sulforaphane And Non-Clustered Tumor/Non-Tumor Suppressor Micrornas Regulate Akt And Its Downstream Genes In Mda-Mb-231 Cancer Cells, Omobolanle David Garuba Oct 2025

Sulforaphane And Non-Clustered Tumor/Non-Tumor Suppressor Micrornas Regulate Akt And Its Downstream Genes In Mda-Mb-231 Cancer Cells, Omobolanle David Garuba

Dissertations (2016-Present)

Cancer is a complex pathological condition characterized mainly by uncontrolled rapid cell divisions caused by several factors, which include genetics and environmental factors. Of all cancer types, breast cancer (BC) remains the second most diagnosed among women worldwide; thus, BC burden has become a global health issue. Of all known breast cancer subtypes, triple-negative breast cancer (TNBC) is the only primary subtype without effective therapy as a result of their lack of the essential estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) common to other BCs and are the usual therapeutic targets for treatment. …


Detection Of Microplastics In Household Dust From Suburban Texas And Toxicological Assessment Of Polystyrene Microparticles In Lung Epithelial Cells: Nf-Kb Pathway Activation And Inflammatory Responses, Nirupama Surubhotla Oct 2025

Detection Of Microplastics In Household Dust From Suburban Texas And Toxicological Assessment Of Polystyrene Microparticles In Lung Epithelial Cells: Nf-Kb Pathway Activation And Inflammatory Responses, Nirupama Surubhotla

Dissertations (2016-Present)

Microplastics are emerging contaminants that have raised global concern due to their persistence, ubiquity, and potential impacts on human health. Indoor environments are increasingly recognized as significant sources of microplastic exposure through household dust inhalation. This study aimed to detect the presence of microplastics in household dust from suburban regions of Texas, USA, and to investigate the cytotoxic and inflammatory effects of polystyrene microparticles in a lung epithelial cell model (A549). Household dust samples were collected and analyzed using Raman spectroscopy, confirming the presence of a mixture of microplastics. To assess biological responses, A549 cells were exposed to defined sizes …


Curcumin And Compound-20 (A Synthetic Curcumin) Ameliorates Effects Of Acrolein In Rat Kidney By Improving Renal Autophagy, Sandra Isioma Erue Oct 2025

Curcumin And Compound-20 (A Synthetic Curcumin) Ameliorates Effects Of Acrolein In Rat Kidney By Improving Renal Autophagy, Sandra Isioma Erue

Dissertations (2016-Present)

Study aim is to determine the role of p38-MAPK/Nrf2 and NF-κB signaling in acrolein-induced kidney injury. Evaluate autophagy modulation and whether curcumin and Compound 20 mitigate acrolein-induced kidney injury by modulating p38-MAPK/Nrf2 and NF-κB pathways. Male Sprague–Dawley rats were randomly divided into groups (n = 5) for control and treatment. All rats were fasted for 4–5 hours daily throughout the 10-day study period. Male Sprague–Dawley rats were administered peanut butter, curcumin, or Compound-20 mixed with peanut butter via voluntary oral consumption, followed by intraperitoneal (IP) administration of acrolein. The animals were randomly divided into groups (n = 5) for control …


From Nociception In Aneural Animals To Human Suffering: Toward A Comparative Biology Of Pain, Edgar T Walters Oct 2025

From Nociception In Aneural Animals To Human Suffering: Toward A Comparative Biology Of Pain, Edgar T Walters

Faculty, Staff and Student Publications

Pain is a core feature of human life, but systematic comparisons of this biological trait across taxa have been rare. A broadly accepted definition based on human experience emphasizes dual features of pain: a sensory (discriminative) component for sensing and monitoring tissue injury, and an affective (emotional) component to motivate avoidance of tissue distress. Conscious pain is coupled to unconscious nociception (detection of incipient or existing injury). This Review considers nociception and pain across phyla within a comparative framework, addressing basic questions about evolutionary origins, mechanisms and functions of pain. The occurrence of adaptive cellular responses to injury in virtually …


Epigenetic Age Acceleration Mediates Treatment Effects On Cardiometabolic And Cardiovascular Risk In Childhood Cancer Survivors, Xiaoxi Meng, Tiffany Eulalio, Yoonji Kim, John Easton, Heather L Mulder, Emily Walker, Geoffrey Neale, Nan Song, Kyla Shelton, Rebecca M Howell, Mengqi Xing, Sedigheh Mirzaei, Deo Kumar Srivastava, Bonnie Ky, Stephanie B Dixon, Melissa M Hudson, Kirsten K Ness, Gregory T Armstrong, Zhaoming Wang Oct 2025

Epigenetic Age Acceleration Mediates Treatment Effects On Cardiometabolic And Cardiovascular Risk In Childhood Cancer Survivors, Xiaoxi Meng, Tiffany Eulalio, Yoonji Kim, John Easton, Heather L Mulder, Emily Walker, Geoffrey Neale, Nan Song, Kyla Shelton, Rebecca M Howell, Mengqi Xing, Sedigheh Mirzaei, Deo Kumar Srivastava, Bonnie Ky, Stephanie B Dixon, Melissa M Hudson, Kirsten K Ness, Gregory T Armstrong, Zhaoming Wang

Faculty, Staff and Student Publications

BACKGROUND: Childhood cancer survivors are at increased risk for epigenetic age acceleration (EAA) and subsequent morbidities, including cardiometabolic risk factors (CMRFs) and cardiovascular diseases, because of prior genotoxic treatments.

OBJECTIVES: The aim of this study was to evaluate the mediating role of EAA in the relationship between cancer treatment exposures and risk for CMRFs and cardiovascular diseases.

METHODS: This study included 2,939 5-year survivors from SJLIFE (St. Jude Lifetime Cohort) who underwent DNA methylation profiling using peripheral blood mononuclear cells. EAA was calculated using 3 established epigenetic clocks: DunedinPACE, PCPhenoAge, and GrimAge2. Treatment data, including body region-specific radiotherapy (RT) and …


Pka-Driven Spp1 Activation As A Novel Mechanism Connecting The Bone Microenvironment To Prostate Cancer Progression, Pablo Sanchis, Agustina Sabater, Julia Lechuga, Jimena Rada, Rocio Seniuk, Gaston Pascual, Mora Gatti, Juan Bizzotto, Peter D A Shepherd, Jun Yang, Javier Cotignola, Elba Vazquez, Joaquin Mateo, Pia Valacco, Estefania Labanca, Christopher Logothetis, Geraldine Gueron, Nicolas Anselmino Oct 2025

Pka-Driven Spp1 Activation As A Novel Mechanism Connecting The Bone Microenvironment To Prostate Cancer Progression, Pablo Sanchis, Agustina Sabater, Julia Lechuga, Jimena Rada, Rocio Seniuk, Gaston Pascual, Mora Gatti, Juan Bizzotto, Peter D A Shepherd, Jun Yang, Javier Cotignola, Elba Vazquez, Joaquin Mateo, Pia Valacco, Estefania Labanca, Christopher Logothetis, Geraldine Gueron, Nicolas Anselmino

Faculty, Staff and Student Publications

Prostate cancer (PCa) bone metastasis (BM) poses a significant clinical challenge due to the heterogeneity of treatment responses and patient outcomes. In this study, we examined the role of Protein Kinase A (PKA) signaling in modulating the expression of osteopontin (SPP1/OPN), a protein associated with poor prognosis, within a subset of PCa BM patients. By integrating multi-omics results we identified a novel mechanism in which bone-derived type-I collagen (Col1a1) and fibronectin (Fn1) stimulate SPP1 expression in PCa cells through the activation of PKA signaling. This bone-induced regulation of SPP1 was confirmed both in vitro, using PCa-bone co-culture systems (PC3 or …


Investigating The Effect Of Gene Ncu07872 Deletion On Spore Killing By Neurospora Sk-3, Allison Rimmey Oct 2025

Investigating The Effect Of Gene Ncu07872 Deletion On Spore Killing By Neurospora Sk-3, Allison Rimmey

Senior Theses – Biological Sciences

The selfish genetic element Spore killer-3 (Sk-3) is found in some Neurospora fungi. Sk-3 is considered selfish because it has evolved the capacity to bias its transmission to the next generation through spore killing. The mechanism of spore killing requires at least two genes, a gene that produces a resistance protein (an antidote) and a gene that produces a killer protein (a poison). The Sk-3 genetic element is millions of base pairs long and contains hundreds of genes. Although the antidote gene has been identified, the identity of the poison gene has remained elusive. Previous research has identified a DNA …


Understanding Animal Introductions And Welfare In Zoos: A Scoping Review, Claudia C. Martinez, Valerie James-Aldridge, Todd J. Mcwhorter, Eduardo J. Fernandez Oct 2025

Understanding Animal Introductions And Welfare In Zoos: A Scoping Review, Claudia C. Martinez, Valerie James-Aldridge, Todd J. Mcwhorter, Eduardo J. Fernandez

Psychological Science Faculty Publications

Managing captive zoo species often requires modifying their social groups, but these changes can increase stress and aggression. Specifically, introductions of new animals to existing exhibits with established animals is commonplace, yet little has been published to systematically evaluate this process. This review used the PRISMA framework to evaluate published research on introductions of unfamiliar individuals in zoos, aquariums, and sanctuaries. Peer-reviewed studies from PubMed, Web of Science, and Scopus were screened and extracted using Covidence software. Studies were included if they provided quantitative data and before-and-after comparisons. Of 25 studies meeting criteria, most focused on primates, especially western lowland …


Smart Search Results For Growth And Economic Performance Comparison Of Twenty-Year-Old ... Refine Results For Arkansas Net Energy: A Productive Energy System Sensitive To Broiler Performance And Body Composition Arkansas Net Energy: A Productive Energy System Sensitive To Broiler Performance And Body Composition 21 Of 94 Arkansas Net Energy: A Productive Energy System Sensitive To Broiler Performance And Body Composition, Diego A. Martinez, Nawin Suesuttajit, Cole Umberson, Craig N. Coon Oct 2025

Smart Search Results For Growth And Economic Performance Comparison Of Twenty-Year-Old ... Refine Results For Arkansas Net Energy: A Productive Energy System Sensitive To Broiler Performance And Body Composition Arkansas Net Energy: A Productive Energy System Sensitive To Broiler Performance And Body Composition 21 Of 94 Arkansas Net Energy: A Productive Energy System Sensitive To Broiler Performance And Body Composition, Diego A. Martinez, Nawin Suesuttajit, Cole Umberson, Craig N. Coon

Poultry Science Faculty Publications and Presentations

This study determined the sensitivity of productive energy (PE; Arkansas Net Energy) to performance and body composition and developed predictive models based on PE. Chicks (2,148 day-old ones) were placed in 96 pens and assigned to one of 12 dietary treatments, including varying concentrations of total digestible amino acids (TDAA), digestible CP (dCP), digestible fat (dFat), digestible starch, and non-starch polysaccharides (NSP). Eight replications per treatment, one per block, were used, being the block consecutive groups of birds weekly starting the seven-day experimental period. In each block, birds were control fed to meet similar ME intake, placed in calorimetry chambers …


Productive Energy, As Determined By Arkansas Net Energy, Predicts Broiler Processing Weights, Carcass Market Value, And Gross Profit, Diego A. Martinez, Nawin Suesuttajit, Cole Umberson, Craig N. Coon Oct 2025

Productive Energy, As Determined By Arkansas Net Energy, Predicts Broiler Processing Weights, Carcass Market Value, And Gross Profit, Diego A. Martinez, Nawin Suesuttajit, Cole Umberson, Craig N. Coon

Poultry Science Faculty Publications and Presentations

This study assessed the sensitivity of Productive Energy (PE) to breast meat production, feed efficiency, and broiler economics, developed models for processing traits and economics, and examined economics dynamics. The experimental design involved 96 pens, 12 per block and eight blocks, with each pen within block receiving one of 12 dietary treatments for one week. Treatment diets, varying in amino acid concentrations, starch, and energy densities, were control-fed. The weights of processing body parts and net energy for gain (NEg) were determined with Dual-Energy X-Ray Absorptiometry, and fed heat production, fasting heat production (FHP), and net energy for maintenance (NEm) …


Effects Of Heat Stress And Depressed Feed Intake On The Cecal And Ileal Microbiota Of Broiler Chickens, Philip M. Campos, Elizabeth S. Greene, Monika Proszkowiec-Weglarz, Sami Dridi Oct 2025

Effects Of Heat Stress And Depressed Feed Intake On The Cecal And Ileal Microbiota Of Broiler Chickens, Philip M. Campos, Elizabeth S. Greene, Monika Proszkowiec-Weglarz, Sami Dridi

Poultry Science Faculty Publications and Presentations

Chronic heat stress (HS) is known to depress feed intake (FI) and growth in broiler chickens, and may alter the gut microbiota and health, however, the amplitude and duration of each (HS and depressed FI) effect on gut microbiota is still unclear. This study aimed to determine the effects of chronic and acute HS on the cecal and ileal microbiota profiles. Broilers were subjected to thermoneutral (TN, 23 degrees C) or chronic cyclic HS (CHS, 8 h/d, 35 degrees C) condition from d29-42, and one group to acute HS (AHS, 2 h, 35 degrees C) at d42. To distinguish between …