Digital Commons Network^™

Nivolumab Plus Ipilimumab Induce Hyper-Progression In Renal Medullary Carcinoma: Results Of A Phase Ii Trial And Preclinical Evidence, Melinda Soeung, Xinmiao Yan, Ciro Zanca, Jing Qian, Menuka Karki, Fei Duan, Hania Khan, Li Zhang, David H Peng, Mariah Williams, Rong He, Ziheng Chen, Luigi Perelli, Jianfeng Chen, Rebecca S Tidwell, Pankaj K Chauhan, Courtney N Le, Truong N A Lam, Nirjar Bhattacharya, Rutvi Shah, I-Lin Ho, Jason P Gay, Caroline C Carrillo, Ningping Feng, Kang Le, Guang Gao, Teresa L Perry, Faika Mseeh, Yongying Jiang, Quanyun A Xu, Niki Marie Zacharias, Rahul A Sheth, Tharakeswara K Bathala, Priya Rao, Najat C Daw, Durga N Tripathi, Cheryl L Walker, Mohammad M Mohammad, Jianhua Zhang, Guangchun Han, Yanshuo Chu, Ruiping Wang, Minghao Dang, Enyu Dai, Fuduan Peng, Yunhe Liu, Akshaya Jadhav, Wenhua Lang, Claudio A Arrechedera, Leticia Campos Clemente, Edwin R Parra, Hsinyi Lu, Cara L Haymaker, Ignacio I Wistuba, Andrew Futreal, Andrea Viale, Michael J Soth, Philip Jones, Joseph R Marszalek, Timothy Heffernan, Giulio F Draetta, Nizar M Tannir, Jianjun Gao, Linghua Wang, Giannicola Genovese, Pavlos Msaouel

Faculty, Staff and Students Publications

Therapeutic options for patients with renal medullary carcinoma (RMC) are limited. Here we report the results of a phase II clinical trial (NCT03274258) of anti-PD1 nivolumab plus anti-CTLA4 ipilimumab in patients with RMC, with objective response rate as primary outcome. Enrollment was halted for futility at a prespecified interim analysis as all 10 treated patients experienced rapid disease progression. 5/10 met radiological criteria for hyperprogression and median progression-free survival (secondary outcome) was 1.38 months (95% confidence interval: 1.28, 1.60). In a post-hoc single-cell RNA sequencing analysis, data from patients with RMC before and after nivolumab plus ipilimumab treatment indicated that …

Immunological Surveillance Against Cancer Across Mammals, Orsolya Vincze, Piotr Minias, Alexandre Corthay, Fernando Colchero, Jean-François Lemaître, Louise Maille, Tamás Malkócs, Justus Hagemann, Dalia A. Conde, Samuel Pavard, Antoine M. Dujon, Beata Ujvari, Frédéric Thomas, Amy M. Boddy, Carlo C. Maley, Damien Chevallier, Tuul Sepp, Thomas Pradeu, Mathieu Giraudeau

Presidential Fellows Articles and Research

Contrary to expectations based on their higher cell numbers, larger and longer-lived species do not face dramatically increased risk of cancer. This strongly suggests that evolution has fashioned natural cancer resistance mechanisms, yet our knowledge remains limited on what these mechanisms might be. The cancer immunological surveillance hypothesis, proposed by Burnet and Thomas in the 1950s, highlights immunity as a key factor determining species-specific cancer resistance. Here we address the original, evolutionary interpretation of this hypothesis by investigating the relationship between cancer mortality risk and markers of efficient antigen presentation. Our results show that the expansion of the MHC class …

A Silver Spoon Effect Reduces Lifetime Fitness In A Declining Loon Population, Walter H. Piper, Claudia Kodsuntie, Hayden Walkush

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

A complete understanding of factors that influence animal fitness requires that we measure not only those occurring day to day in the life of an animal but also those that operate on longer time scales. Here, we investigated silver spoon effects (fitness impacts resulting from conditions faced early in life) and carryover effects (fitness impacts caused by environmental factors in a previous season) in a northern Wisconsin population of the common loon (Gavia immer). The mass of a loon chick divided by its age, an indication of food it received from its parents in its first 4 to …

The Effect Of Noise Pollution On The Diversity And Abundance Of Bird Species At Different Locations At Warner Parks, Nashville, Tn, Jeremy T. Little, Wyatt L. Fooks, Darlene Panvini, Jackson Whiteside

Science University Research Symposium (SURS)

Noise pollution is a significant abiotic factor that can alter bird biodiversity and abundance of birds in urbanized areas. A new road is proposed through a relatively untouched area of Warner Parks in Nashville, TN, which may affect the bird community. Acoustic Song Meters were used to monitor bird sounds and soundscapes in the proposed road site and two areas of the park with different levels of noise pollution (roadside=high noise; isolated=low noise) for three weeks. Recordings were analyzed to determine bird species and abundance at each site to predict how increasing noise pollution may affect bird diversity in the …

Red Snapper (Lutjanus Campechanus) Neurocranium, Gabriella K. Flora, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

Investigating The Mechanisms Of Microbial Interactions Using A Model Cystic Fibrosis Polymicrobial Community, Bassam El Hafi

Dartmouth College Ph.D Dissertations

Cystic fibrosis (CF) airway microbial communities are complex ecosystems where interspecies interactions influence pathogen survival and disease progression. We leverage a CF-relevant in vitro four-species model composed of Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus sanguinis, and Prevotella melaninogenica, alongside a microbiome dataset with over 4,000 respiratory samples from publicly available sequencing data of CF patient samples, to explore the dynamics of microbial interactions in CF. On a broader scale, we performed microbial network analysis to examine how the latest modulator therapy, elexacaftor/tezacaftor/ivacaftor (ETI), might influence CF microbial communities. Our analysis revealed a reduction in node connections and …

Live-Cell Quantitative Monitoring Reveals Distinct, High-Affinity Gβγ Regulations Of Girk2 And Girk1/2 Channels, Reem Handklo-Jamal, Tal Keren Raifman, Boris Shalomov, Patrick Hofer, Uri Kahanovitch, Theres Friesacher, Galit Tabak, Vladimir Tsemakhovich, Haritha P Reddy, Orna Chomsky-Hecht, Debi Ranjan Tripathy, Kerstin Zuhlke, Carmen W Dessauer, Enno Klussmann, Yoni Haitin, Joel A Hirsch, Anna Stary-Weinzinger, Daniel Yakubovich, Nathan Dascal

Faculty, Staff and Student Publications

Gi/o protein-coupled receptors (GPCRs) inhibit cardiac and neuronal excitability via G protein-activated K+ channels (GIRK), assembled by combinations of GIRK1 - GIRK4 subunits. GIRKs are activated by direct binding of the Gβγ dimer of inhibitory Gi/o proteins. However, key aspects of this textbook signaling pathway remain debated. Recent studies suggested no Gi/o-GIRK pre-coupling and low (>250 µM) Gβγ-GIRK interaction affinity, contradicting earlier sub-µM estimates and implying low signaling efficiency. We show that Gγ prenylation, which mediates Gβγ membrane attachment required for GIRK activation, also contributes to the Gβγ-GIRK interaction, explaining the poor affinity obtained with non-prenylated Gβγ. Using quantitative …

Naphthalimide-Based Type-I Nano-Photosensitizers For Enhanced Antitumor Photodynamic Therapy: H2s Synergistically Regulates Pet And Self-Assembly, Huiyu Niu, Songnan Wang, Yang Liu, Nana Ma, Shuaiwei Cheng, Beidou Feng, Hyunsun Jeong, Yonggang Yang, Ge Wang, Tony D James, Juyoung Yoon, Jonathan L Sessler, Hua Zhang

Faculty, Staff and Student Publications

Photodynamic therapy (PDT) relies on a combination of light and photosensitizers (PSs) to achieve local control over cancerous lesions. However, it is subject to limitations, including tumor hypoxia, low tumor targeting, off‐target phototoxicity, and always‐on fluorescence. Here, we propose a design strategy for activated nano‐PSs (N‐PSs) to simultaneously overcome the limitations of PDT, wherein photoinduced electron transfer (PeT) is coupled with an endogenous H2S‐regulated self‐association process to promote Type‐I photochemical reactions. Using theoretical calculations, spectral analysis, and microscopic imaging, we verified the generation of self‐assembly and occurrence of PeT. And it was also shown that H2S could synergistically inhibit the …

2025 - The Sixth Annual Fall Symposium Of Student Scholars

Symposium of Student Scholars Program Books

The full program book from the Fall 2025 Symposium of Student Scholars, held in November 2025. Includes abstracts from the presentations and posters.

Fish-Spec: Fast Identification System For Handheld Spectroscopy And Species Classification, Mitchell Sueker, Nicholas Mackinnon, Gregory Bearman, Amanda Tabb, Diane Kim, Rosalee S. Hellberg, Alireza Akhbardeh, Hamid Reza Marateb, Jianwei Qin, Moon Kim, Fartash Vasefi, Hossein Kashani Zadeh

Food Science Faculty Articles and Research

Accurate fish species identification is critical to prevent mislabeling and fraud in the seafood industry. We present a handheld multi-mode point spectroscopy system that combines fluorescence (365 and 395 nm excitation) and reflectance measurements in the visible to near-infrared (∼350–900 nm) and short-wave infrared (∼900–1700 nm) regions for rapid, non-destructive classification of fish fillets. Tissue spectra were acquired at 25 positions on 68 fillets from 11 species, in both frozen and thawed states. Feature-level fusion across all four modes enabled higher classification accuracy than any single mode alone. A global machine-learning model classified all species with 85 ± 2.8 %, …

Forage Mass And Botanical Composition Of Four Annual Forages Grown In A Loblolly Pine Silvopasture In The Mid-South Usa, Christine C. Nieman, Dirk Philipp, Jonathan O.C. Kubesch

Animal Science Faculty Publications and Presentations

Annual forages are commonly planted in open pasture in the Mid-South, but there is little information on the productivity of these forages when incorporated into silvopasture. The objective was to evaluate four annual forages adapted to the Mid-South, namely, arrowleaf clover (Trifolium vesiculosum Savi), crimson clover (Trifolium incarnatum L.), tetraploid annual ryegrass (Lolium multiflorum L.), and diploid annual ryegrass (Lolium multiflorum L.), in a loblolly pine (Pinus taeda L.) silvopasture for seasonal forage mass distribution and annual forage accumulation. The forages were tested in a randomized complete block design with three replicates and three harvests per year: Harvest 1 (H1, …

Renewal Of The Mind: Forgiveness Through The Lens Of Christian Faith And Neuroscience, Khelen Walsh

University Honors Theses

Within Christian theology, forgiveness is a foundational concept that is often understood as a divine command, a spiritual practice, and a path toward reconciliation and personal growth. Recent neuroscientific research further supports this viewpoint, providing data that shows forgiveness engages neural systems responsible for emotional regulation, empathy, moral reasoning, and perspective-taking. Through neuroplasticity, repeated acts of forgiveness reshape the brain, strengthen connections between prefrontal and limbic regions, reduce amygdala reactivity, and enhance emotional stability and cognitive flexibility. Although forgiveness offers many benefits, modern culture frequently distorts its meaning, framing it as a sign of weakness, gullibility, or a form of …

Harnessing Hyperspectral Imaging And Deep Learning For Terrestrial Habitat Mapping In Arid Landscapes: A Case Study In Saudi Arabia, Ali Elgendy, Hesham Morgan, Brandon Tran, Rejoice Thomas, Tamer Ismail, Yehya Kh. Shehadeh, Ahmed Elgharib, Ahmed Abdullah Al-Dughairi, Ali El Muburak, Khaled Allam Harhash, Hesham El-Askary

Mathematics, Physics, and Computer Science Faculty Articles and Research

Arid ecosystems remain under-mapped at actionable scales despite their ecological importance. Decision makers lack reliable, high-resolution habitat maps in drylands to prioritize protection and target restoration. This research integrates spaceborne hyperspectral imaging from the Environmental Mapping and Analysis Program (EnMAP) with deep learning semantic segmentation models to produce an updated level of habitat classification based on the International Union for Conservation of Nature (IUCN) for part of the Imam Turki bin Abdullah Royal Reserve, Saudi Arabia. Using ground control points and the full EnMAP spectral cube without band selection, U-Net and DeepLabV3+ architectures were each implemented with VGG19 and ResNet-101 …

Blackeyed Susan Establishment And Injury Following Application Of Common Roadsides Herbicides, Rachel C. Woody-Pumford, Matt Bertucci, Mike D. Richardson, Dirk Phillip, Hannah E. Wright-Smith

Horticulture Faculty Publications and Presentations

Limited herbicide options are available for selective weed management in roadside native plantings. Thus, this field study evaluated blackeyed Susan's (Rudbeckia hirta L.) tolerance to four postemergence (POST) herbicides-quinclorac, florpyrauxifen-benzyl, clopyralid, and metsulfuron-during prairie establishment in Fayetteville, AR, across two growing seasons in 2022 and 2023. Blackeyed Susan was assessed for plant incidence, bloom count, and visible injury. In 2022, no reduction in blackeyed Susan blooms was detected in response to POST herbicides; however, peak bloom counts occurred 1 week after treatment (WAT) and ranged from 1.1 to 1.6 blooms per ft2. In 2023, at 10 WAT, blackeyed Susan plants …

Divergent Prefrontal Cortex Circuits Regulate Cued Food Seeking Under Distinct Metabolic Or Emotional States, Xu O Zhang, Guillermo Aquino-Miranda, Claire E Cho, Yongzhe Wang, Duy Hoang Ha, Nikita Elinson-Watson, Allen Dong, Caleb Kemere, Fabricio H Do-Monte

Faculty, Staff and Student Publications

Flexibly adjusting food-seeking behaviour in response to food-associated cues and internal states is crucial for animals' survival. However, the neural mechanisms that modulate cued food-seeking behaviour during varying metabolic (i.e., hungry vs. satiated) and emotional (i.e., safe vs. threatened) states remain elusive. Here, we show that the encoding of metabolic or threat states in projection-defined neurons in the prelimbic cortex (PL) mediates cued food-seeking responses in rats. Using microendoscopic imaging, we demonstrate that neural population dynamics in PL consistently represent food cues, task-relevant behaviours, and internal state changes by recruiting distinct subsets of cue-responsive neurons at each state. Single-unit recording …

Economic Convergence, Intragenerational Economic Mobility, And Inequality In A Native Amazonian Small-Scale Society Of Indigenous People In Bolivia, Ricardo Godoy, Jonathan Bauchet, Victoria Reyes-Garcia, Eduardo A. Undurraga

Department of Agricultural Economics Faculty Publications

Adult intragenerational mobility reflects society’s ability to reward effort and tame society-wide inequality. In developed economies, mobility is modest and correlates negatively with economic inequality. Little is known quantitatively from direct observations about long-term intragenerational mobility in small-scale societies of the Global South. To assess the external validity of findings about patterns of intragenerational mobility from developed economies, we use a yearly survey panel dataset (2002–2010) of adults from a society of native Amazonians (Tsimane’) in Bolivia practicing farming, fishing, hunting, and plant gathering. We estimate (a) convergence rates (or the speed of catch up) of adults in the bottom …

Spicomellus The Jurassic Enigma, Bryan Nam

Osmosis Magazine

Imagine stepping into a time machine and messing with the controls until you find someplace interesting to go. Your destination? Morocco, 165 million years ago. You arrive and look around at vast floodplains stretching far across the horizon; flat land cut through by mighty rivers. In the distance, you see something, a creature unlike any you’ve ever seen before. It looks straight out of a sci-fi movie. It seems almost like a reptilian tank, with huge spikes on its neck and hips. The dinosaur looks towards you, then turns away to look for food. You have just come face to …

Synthetic Biology: Could You Donate Yourself A New Kidney?, Charlie Lanning

Osmosis Magazine

Currently in the United States, there are over 100,000 Americans stuck on the national transplant waiting list for lifesaving surgery. Eighty-six percent of them need kidney transplants (Organ Donation Statistics, 2025). However, only 27,000 kidney transplants take place every year. This shortage, along with other factors such as lack of public awareness, donor health complications, and financial disincentives, results in around 4,000 deaths every year (Soltani-Nia, 2024). While organizations such as the Organ Procurement and Transplantation Network and the National Kidney Registry have helped increase the number of transplants through public advocacy and the voucher program, emerging technologies such as …

Osmosis.

Osmosis Magazine

Science Magazine

Insect Apocalypse? Population Patterns Of Aquatic Macroinvertebrates Across North America, Analiese Kate Bauder

Honors Thesis

There is a common idea that there is an “insect apocalypse”, that insect populations are on a drastic decline. To test this hypothesis we took data collected by the National Ecological Observatory Network (NEON) from 2015 to 2023 and analyzed it to create a time series model depicting the population of aquatic macroinvertebrates at 34 sites across North America (Appendix 1). NEON is an NSF funded, continental-scale observation facility designed to collect long-term open-access ecological data to better understand the complexities of Earth's ecosystems and how they are changing. From this model, we defined the slope of the change in …

Linking A Seasonal Freshwater Prey Subsidy To The Body Condition Of An Estuarine Consumer In A Subtropical Coastal River, Jordan A. Massie, Ryan J. Rezek, W. Ryan James, Rolando O. Santos, Natasha M. Viadero, Ross E. Boucek, Jennifer S. Rehage

Marine Science

Movements of fishes among habitats often correspond to shifting resource availability and can occur in response to fluctuating freshwater inflows in coastal systems. Seasonal availability of prey can provide resources that increase fitness, yet hydrologic variability can influence the movements of both consumers and prey. Shifts in the timing/magnitude of prey availability driven by climate and water management may lead to a resource mismatch, carrying consequences for growth, survival, and reproduction. Here, we examined how seasonal/interannual variation in prey biomass (sunfishes, Lepomis spp.) affects the body condition of Common Snook (Centropomus undecimalis) in Everglades National Park. Further, we investigated how …

Effect Of Neuroinflammation On Exploratory Behavior In Mice, Gage Pompa, Ariana Mitic, Yader Gomez, Lilian Hagos, Orlando Montiel

Undergraduate Research Symposium Posters

Introduction: Mice have been observed in both laboratory and field settings to exhibit a tendency to remain near corners and walls. This trait is known as positive thigmotaxis. Thigmotaxis has been recognized as a fundamental aspect of rodent behavior and used extensively as an anxiety index in mice. Although this characteristic has been recognized as a fundamental aspect of rodent behavior, thigmotaxis has been extensively studied in rectangular and circular environments. However, there is a notable lack of understanding of how alternative geometric configurations can influence this behavior.

Methods and Approach: Using a grid overlaid on the environment the mice …

Great Hammerhead (Sphyrna Mokarran) Chondrocranium, Female, Nicholas Burchett, Michelle Bassali, Marissa Rosas, Rileigh Gonzalez, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

Atlantic Goliath Grouper (Epinephelus Itajara) Vertebrae, Nicholas Burchett, David W. Kerstetter, Rileigh Gonzalez, Sierra Rafacz, Ema Nagel

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

Both Studying And Protecting Octopuses “On Their Own Terms”, Jennifer Jacquet, Janelle Kaz, Becca Franks, Christine Webb

Animal Sentience

Cephalopods – indeed, all animals – “must be seen on their own terms,” with respect for their autonomy and their ecological imperatives. This will provide greater scientific insight along with a more ethical and accurate understanding of minds beyond our own.

Design And Validation Of A Bilateral, Multi-Site 3d-Printed Neuronal Implant For Rodent Electrophysiology, Homero Phelps, Jonathan V. Trinidad, Talha Soluoku

Undergraduate Research Symposium Podium Presentations

Neuronal electrophysiology implants are essential tools in neuroscience for recording brain activity and investigating neurological disorders. Our lab’s previous 3D-printed implant designs centered around a single-site, recording platform that was limited in adaptability, precision, and lacked in vivo validation due to lingering engineering malfunctions. To combat limitations and expand recording capabilities, this project aimed to design and validate a new implant capable of multi-site, bilateral recordings across both brain hemispheres, specifically targeting the hippocampus (CA1 and CA3) and anterior cingulate cortex (ACC), regions critical for learning and memory. Building on the Open Ephys ShuttleDrive model, the implant was redesigned using …

Dorsal/Ventral Orientation Of Dentate Granule Cells And Its Impact On Electrophysiology In Mice, Jacob Prince, Savannah Sampson, Alyssa Marron

Undergraduate Research Symposium Posters

The hippocampus has known roles in memory formation, learning, and spatial mapping. There are defined physiological differences between CA1 neurons based on their dorsal to ventral position within the 3D hippocampus (Malik et al., 2015). Given the varying functions of the dorsal and ventral hippocampus in cognitive processing and the role of the dentate gyrus as the entry point for information into the hippocampus, it will be interesting to determine if there are differences in the properties of granule cells across the dorsal and ventral axis. We explore the potential topographic specialization of dentate granule cells. This study examines the …

Liver-Directed Base Editing Of Abcc6 Prevents Ectopic Calcification In A Variant-Humanized Mouse Model Of Pseudoxanthoma Elasticum, Lauren C. Testa, Dora Obiri-Yeboah, Hooda Said, Ping Qu, Michael A. Levine, Mohamad-Gabriel Alameh, Kiran Musunuru, Qiaoli Li, Xiao Wang

Department of Biochemistry and Molecular Biology Faculty Papers

Pseudoxanthoma elasticum (PXE) is an autosomal recessive connective tissue disorder characterized by ectopic calcification of elastic fibers throughout the skin, retina, and arteries. It is caused by pathogenic variants in ABCC6 , which encodes a transmembrane transporter that primarily localizes to hepatocytes. Loss of ABCC6 function in hepatocytes leads to systemic deficiency of inorganic pyrophosphate (PPi), a potent inhibitor of calcification; such depletion of PPi from the circulation is responsible for multisystemic ectopic calcification seen in PXE. Therefore, liver-targeted variant correction by genome editing and subsequent restoration of systemic PPi may offer a one-and-done therapeutic approach for PXE. The ABCC6 …

Shp2: A Redox-Sensitive Regulator Linking Immune Checkpoint Inhibitor Therapy To Cancer Treatment And Vascular Risk, Silvia Fernanda López Moreno, Stefania Assunto Lenz, Bernardo Casso-Chapa, Angelica Paniagua-Bojorges, Jung Hyun Kim, Nicolas L Palaskas, Kevin T Nead, Venkata S K Samanthapudi, Gilbert Mejia, Oanh Hoang, Jonghae Lee, Steven H Lin, Joerg Herrmann, Guangyu Wang, Syed Wamique Yusuf, Cezar A Iliescu, Noah I Beinart, Charlotte Manisty, Masuko Ushio-Fukai, Tohru Fukai, Pietro Ameri, Roza I Nurieva, Michelle A T Hildebrandt, Keri Schadler, Efstratios Koutroumpakis, Sivareddy Kotla, Nhat-Tu Le, Jun-Ichi Abe

Faculty, Staff and Student Publications

Src homology 2-domain containing protein tyrosine phosphatase 2 (SHP2), encoded by the Ptpn11 gene (Tyrosine-protein phosphatase non-receptor type 11), is a key downstream effector of PD-1/PD-L1 signaling and is likely important, in addition to immune modulation, in tumor development and vascular homeostasis. SHP2 conveys PD-1 mediated inhibitory signaling in T cells, and is emerging as a therapeutic target. Importantly, there is an association between immune checkpoint inhibitors (ICIs), immune-related adverse events (irAEs), and cardiovascular complications, underscoring the need to understand SHP2’s role in these processes. This review aims to summarize current knowledge on SHP2/PTPN11 biology, its role in immune …

First Report Of A Bat Guano Fire From A Cave In Southeast Asia, Sopark Jantarit, Martin Ellis, Pruet Kalasuwan, Neeranuch Phusunti, Pimonsri Mittraparp-Arthorn, Jiranan Pattano, Arnon Chukamnerd, Turdtun Tong-In, Natthawut Khrueaaunruean

International Journal of Speleology

Fires occurring in cave guano are a rare and unusual phenomenon and the occurrence of such events in Southeast Asia is particularly novel. In this study, we document the first recorded instance of a bat guano fire in a tropical cave at Tham Chao Ram in Sukhothai province, northern Thailand. A bacteriological analysis was made of the guano at the fire site and from a control site within the cave. We give a comprehensive review of global reports on bat guano fires in caves, conduct an initial investigation of the physical factors at the fire site and discuss the potential …