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Articles 211 - 240 of 113985
Full-Text Articles in Entire DC Network
Extinction Risk Of Coral Reef Fishes In The Philippine Marine Ornamental Trade, Jemelyn Grace Baldisimo Sepulveda
Extinction Risk Of Coral Reef Fishes In The Philippine Marine Ornamental Trade, Jemelyn Grace Baldisimo Sepulveda
Biological Sciences Theses & Dissertations
Coral reef ecosystems in the Philippines face severe threats from intense fishing and habitat degradation. This dissertation evaluated the extinction risk of fishes in the Philippine Marine Aquarium Trade (MAT) using Productivity Susceptibility Analysis (PSA) and temporal genomics. A global PSA framework was modified by including local susceptibility factors. Of the 103 species evaluated, six were categorized as highly vulnerable and 62 as moderately vulnerable, revealing increased local vulnerability and underscoring the importance of local assessments to guide conservation efforts.
Temporal genomics compared historical (1908–1909 U.S.S. Albatross Expedition) and contemporary populations of the MAT-targeted Sphaeramia nematoptera and Pseudanthias squamipinnis, …
Physiological, Cognitive, Behavioral, And Perceptual Contributors To Falls Risk Across Middle And Older Adulthood, Jacquelyn Moxey
Physiological, Cognitive, Behavioral, And Perceptual Contributors To Falls Risk Across Middle And Older Adulthood, Jacquelyn Moxey
Rehabilitation Sciences Theses & Dissertations
Falls are multifactorial events influenced by physiological, cognitive, behavioral, and perceptual factors. Although falls prevention research has traditionally focused on older adults and objectively measured physical impairments, less is known about how cognitive performance, physical activity, and perceptions of ability collectively contribute to falls risk vulnerability across middle and older adulthood. This dissertation examined these relationships through three complementary studies.
Study 1 examined associations between cognitive screening performance and physiological falls risk in 315 community-dwelling older adults. Lower global cognitive performance was associated with greater physiological falls risk. Performance on items reflecting attention and visuospatial/executive function demonstrated the strongest domain-level …
Polyphenol Diet And Exercise As Neuroprotection From Effects Of Alzheimer's Disease, Michelle Morgan
Polyphenol Diet And Exercise As Neuroprotection From Effects Of Alzheimer's Disease, Michelle Morgan
Loma Linda University Electronic Theses, Dissertations & Projects
Healthy non-pharmacological lifestyle factors, such as regular physical exercise and a dietary supplementation, have been shown to significantly improve cognitive outcomes over time compared to a more sedentary lifestyle and poor diet. Furthermore, exercise may serve as a potential protective factor in attenuating the effects associated with cognitive decline that are characteristic of neurodegenerative disorders, such as Alzheimer's disease (AD). Further, evidence indicates that certain diet interventions can also attenuate the effects of neurodegeneration and positively impact longevity. Supplementation of polyphenols, such as ellagic acid (EA), which are abundant in pomegranate juice, may help provide neuroprotective benefits and elicit a …
Genetic Regulation Of Uterine Organogenesis, Diana A. Machado
Genetic Regulation Of Uterine Organogenesis, Diana A. Machado
Dissertations and Theses (Open Access)
In eutherian and marsupial mammals, the site of embryo implantation and gestation is the uterus. The precursor tissue of the uterus, oviducts, cervix, and upper vagina is the Müllerian duct epithelium and its adjacent mesenchyme. Morphological uterine variation between species is established during embryogenesis by species-specific differences in Müllerian duct fusion at the midline, growth, and differentiation. For example, laboratory mice have a bipartite uterus with two uterine horns and a single cervix, whereas humans have a simplex uterus with a single chamber and single cervix. In humans, variations in the fusion process can alter typical uterine morphology, correlating with …
Economic Contribution Of The Agricultural Sector To The Arkansas Economy In 2024, Frank Seo, Luke Pullo
Economic Contribution Of The Agricultural Sector To The Arkansas Economy In 2024, Frank Seo, Luke Pullo
AAES Research Reports and Research Bulletins
This report is the nineteenth in a series that examines agriculture’s economic contribution to the Arkansas economy. The total economic contribution of agriculture (direct, indirect, and induced effects) on value added, employment, and labor income was estimated with the Impact Analysis for Planning System (IMPLAN) for the most recent year available, 2024.
Land Condition Standards For The Western Australian Nullarbor Pastoral Region, Peter-Jon A. Waddell, Wayne J. Fletcher
Land Condition Standards For The Western Australian Nullarbor Pastoral Region, Peter-Jon A. Waddell, Wayne J. Fletcher
Natural resources published reports
This report outlines the quantitative land condition standards that define acceptable pastoral land condition for the Western Australian part of the Nullarbor, to meet the regulatory requirements of the Land Administration Act 1997 and the Soil and Land Conservation Act 1945.
The Department of Primary Industries and Regional Development is developing regional-level pastoral land condition standards for Western Australia as a critical component of the Framework for sustainable pastoral management – revised edition (Fletcher 2022), the purpose of which is to address the Office of the Auditor General’s recommendations to improve the management of pastoral lands in WA …
Evaluating The Motivations Of Participants In Online Equine Extension Courses, Sarah Vos
Evaluating The Motivations Of Participants In Online Equine Extension Courses, Sarah Vos
Department of Animal Science: Dissertations, Theses, and Student Research
Traditional program evaluations emphasize participant demographics, knowledge gain, behavior change, and program impact. However, evaluating participant motivation can provide addition insight into why participants enroll in extension programs and help explain participant engagement and persistence throughout a program. The purpose of this study was to evaluate participant motivation in two online equine extension courses and examine potential relationships between motivation, demographics, and course delivery method, and describe participant engagement in Virtual Horse Judging Camp (VHJC). This cross-sectional study utilized convenience sampling of participants in two online equine extension courses, Horse Adult Leader Training and Educational Resource (HALTER) and VHJC. The …
Eusocial Caste Specialization Under Abiotic And Biotic Stress In A Stingless Bee, Tetragonisca Angustula, Kristin M. Robinson
Eusocial Caste Specialization Under Abiotic And Biotic Stress In A Stingless Bee, Tetragonisca Angustula, Kristin M. Robinson
Dissertations
Eusocial insects rely on division of labor to achieve high colony efficiency and provide essential ecosystem services, but specialization may also constrain colony resilience when workers operate near their physiological or behavioral limits under abiotic and biotic stressors. How specialization mediates these responses remains poorly understood, particularly in stingless bees (Tribe: Meliponini). Using the agriculturally relevant stingless bee Tetragonisca angustula, which possesses a specialized soldier subcaste, I investigated how a high degree of worker specialization influences physiological tolerance and predator responses across worker subcastes.
In this dissertation, I quantified variation in thermal tolerance and desiccation resistance among worker subcastes …
History-Dependent Gain Control In The Paraventricular Thalamus: Neural Substrates Of Stress-Enhanced Fear Learning, Michael Martino
History-Dependent Gain Control In The Paraventricular Thalamus: Neural Substrates Of Stress-Enhanced Fear Learning, Michael Martino
MUSC Theses and Dissertations
Post-traumatic stress disorder (PTSD) is characterized by hyperarousal and heightened reactivity that generalize beyond the original traumatic event, yet the neural mechanisms by which prior stress experience biases future fear learning remain poorly understood. Stress-enhanced fear learning (SEFL) is a well-validated rodent model of this phenomenon, in which a severe stressor produces persistent sensitization of subsequent fear acquisition. This dissertation used a 30-day SEFL paradigm to identify the brain-wide functional signature of stress sensitization and to identify candidate neural substrates.
Whole-brain cFos mapping during acute fear acquisition revealed a predominant pattern of suppressed neural activity in sensitized animals, with limbic …
Nutrient Leaching Under Traditional And Intercropped Cover Crop Fields In Northern Utah, Katherine Hewitt
Nutrient Leaching Under Traditional And Intercropped Cover Crop Fields In Northern Utah, Katherine Hewitt
All Graduate Theses and Dissertations, Fall 2023 to Present
This study examines whether cover crops can be used in Utah and the Intermountain West to improve water quality and reduce contamination due to nutrient leaching from agricultural soils into the groundwater. Cover crops such as grasses, clover, and other seed mixtures can be planted to improve soil health, increasing the soil’s ability to retain water and nutrients, which reduces the amount of nitrate and phosphate fertilizers lost through leaching and contamination. In Utah, short growing seasons and limited irrigation water availability hinder the ability to establish cover crops. By planting the cover crop between the rows (intercropping) when the …
A Geometric Morphometric Analysis Of Acetabular Shape Variation Across Bat Families, Jordan L. Huff
A Geometric Morphometric Analysis Of Acetabular Shape Variation Across Bat Families, Jordan L. Huff
Electronic Theses and Dissertations
Bats are the only mammals capable of powered flight, and research is concentrated on this adaptation. Their non-flight locomotion has received comparatively little attention. Previous studies show that non-flight locomotor behaviors vary across families. Members of Pteropodidae are efficient climbers but cannot effectively walk, whereas Phyllostomidae and Vespertilionidae are better at terrestrial locomotion but show reduced arboreal capabilities. The non-flight locomotion of Hipposideridae and Rhinolophidae is less understood, although rhinolophids exhibit limited terrestrial locomotion. This study examined whether differences in locomotor behavior are associated with variation in acetabular morphology. A geometric morphometric analysis of acetabular shape was conducted across multiple …
Flexible Grazing: Evaluating Stocker Cattle As A Drought Management Tool For Utah Livestock Producers?, Ross Israelsen
Flexible Grazing: Evaluating Stocker Cattle As A Drought Management Tool For Utah Livestock Producers?, Ross Israelsen
All Graduate Reports and Creative Projects, Fall 2023 to Present
Drought is a persistent concern in the western United States, often leading to reduced forage production, overgrazing, and economic challenges for livestock producers. This study evaluates the economic feasibility of incorporating stocker cattle as a flexible drought management strategy under varying forage conditions across four Utah grazing locations: Park Valley, Nephi, Vernal, and Beaver. The Rangeland Analysis Platform (RAP) was used to estimate annual forage production and stocking rates from 2001 through 2025. Four stocking-rate scenarios (100%, 75%, 60%, and 50% cow–calf stocking rates) were evaluated using a Net Present Value (NPV) framework to compare the economic performance of traditional …
Function And Regulation Of Long Polar Fimbriae During Enterohemorrhagic Escherichia Coli Infection, Walter J. Galdamez
Function And Regulation Of Long Polar Fimbriae During Enterohemorrhagic Escherichia Coli Infection, Walter J. Galdamez
Dissertations and Theses (Open Access)
Enterohemorrhagic Escherichia coli (EHEC) is a foodborne pathogen that causes severe gastrointestinal disease and hemolytic uremic syndrome. EHEC employs multiple virulence factors to colonize the host intestine, including the locus of enterocyte effacement (LEE) encoded type III secretion system, intimin, and flagella, yet the role of long polar fimbriae (Lpf) in adhesions and infection remains less well understood. Long polar fimbriae can mediate bacterial attachment to host cells in vitro, yet the regulation and function of its two fimbrial operons, lpf1 and lpf2 in vivo remain poorly understood. Preliminary RNA-seq data from zebrafish infected with EHEC reveal that expression of …
Hyperadhesive Von Willebrand Factor Contributes To Pathogenesis Of Preeclampsia, Yajuan Wang, Chenyu Wang, Katie L Houck, Xiaoli Gao, Yuanyuan Chen, Xin Xu, Xue Zhao, Miguel A Cruz, Shu Zhang, Chester Q Li, Fengxia Xue, Min Li, Swati Shree, Jing-Fei Dong, Cha Han
Hyperadhesive Von Willebrand Factor Contributes To Pathogenesis Of Preeclampsia, Yajuan Wang, Chenyu Wang, Katie L Houck, Xiaoli Gao, Yuanyuan Chen, Xin Xu, Xue Zhao, Miguel A Cruz, Shu Zhang, Chester Q Li, Fengxia Xue, Min Li, Swati Shree, Jing-Fei Dong, Cha Han
Children’s Nutrition Research Center Staff Publications
Background: Preeclampsia is the most common complication of pregnancy, significantly affecting maternal and fetal health, and is characterized by placental and systemic endotheliopathy. Patients with preeclampsia have elevated levels of VWF (von Willebrand Factor), which is associated with poor clinical outcomes. However, whether VWF serves as a marker for endotheliopathy or contributes to the pathogenesis of preeclampsia remains poorly understood.
Methods: We investigated the role of hyperadhesive VWF in the development of preeclampsia by studying patients, evaluating mouse models, and performing in vitro experiments.
Results: We show that patients develop VWF- and fibrin-rich thrombosis in the placenta and have significantly …
Can Kinematics Specify Tool Use Affordances?, Tyler Duffrin
Can Kinematics Specify Tool Use Affordances?, Tyler Duffrin
All Dissertations
Object properties such as length, shape, and heaviness, as well as affordance-based properties such as strike-with-ability and poke-with-ability, can be perceived via dynamic touch as functions of inertia tensor invariants. The primary question addressed here was whether people can perceive these same power and precision properties for purely virtual objects, which lack dynamic physical forces. The Kinematic Specification of Dynamics (KSD) principle asserts that missing dynamics are lawfully specified by kinematic (visual) motion patterns, such that kinematic information alone may support successful interactions with virtual objects. In three experiments, we investigated (1) whether virtual reality (VR) users could calibrate to …
Lizards In The Trees: Structural, Functional, And Behavioral Specializations To A High-Risk Environment, Victor D. Munteanu
Lizards In The Trees: Structural, Functional, And Behavioral Specializations To A High-Risk Environment, Victor D. Munteanu
All Dissertations
Animals must contend with unexpected changes in their habitat and environment to thrive. Arboreal habitats can consist of a wide variety of environmental features, and failure to adequately contend with these features can result in high risk of injury or death upon falling. Despite these strong selective pressures, many vertebrate lineages have successfully invaded arboreal habitats. Using lizard taxa as a model system, I investigated how morphology and behavior have evolved within this specific habitat transition. I pursued these investigations through complementary analyses including: 1) evaluating the effect of stance height and tail prehensility on perturbation recovery, 2) assessing behavior …
Effects Of Urbanization On Barrier Island Bobcats, Meghan P. Keating
Effects Of Urbanization On Barrier Island Bobcats, Meghan P. Keating
All Dissertations
Urbanization is a leading driver of ecological change and presents unique challenges for carnivores by altering habitat availability, prey communities, and exposure to anthropogenic threats. Although many carnivore species persist in developed landscapes, the ecological and demographic consequences of urbanization often remain poorly understood, particularly over long timescales. Using one of the longest-running studies of a free-ranging carnivore population, I evaluated the effects of urbanization on the behavior, resource use, exposure risk, and population dynamics of bobcats (Lynx rufus) inhabiting a residentially developed barrier island in coastal South Carolina, USA. I first examined temporal and spatial responses to …
The Past, Present, And Future Of Climate Adaptation In A Widespread Lizard Species, Matthew R. Mcternan
The Past, Present, And Future Of Climate Adaptation In A Widespread Lizard Species, Matthew R. Mcternan
All Dissertations
Climate, as a selective force, shapes patterns of biodiversity globally. However, how species adapt to climate remains a central question of biology. The need to understand climate adaptation is paramount, as global climate change threatens a large portion of global diversity. Climate can impose selection on life by either controlling rates of energy intake and expenditure through effects on body temperature and activity, or by exposing organisms to conditions beyond their physiological limits. Studies of climate adaptation have identified a wide-range of putatively adaptive phenotypic patterns, but genomic evidence is increasingly being used to investigate these patterns and better understand …
Prenatal Acoustic Programming Of The Developing Hypothalamus: A Multi-Omic Analysis Of Heat Call Exposure In Zebra Finch Embryos, Prakrit Subba
Prenatal Acoustic Programming Of The Developing Hypothalamus: A Multi-Omic Analysis Of Heat Call Exposure In Zebra Finch Embryos, Prakrit Subba
All Dissertations
Climate change is intensifying thermal stress on wildlife globally, yet the developmental mechanisms by which embryos use prenatal cues to adjust to predicted environments remain unclear. In Australian zebra finches (Taeniopygia guttata), incubating parents produce distinctive heat call vocalizations at high ambient temperatures, and embryos exposed to these calls during late incubation develop altered growth trajectories, thermoregulatory capacity, and reproductive outcomes, suggesting a form of anticipatory developmental programming triggered by sound alone. To investigate the molecular basis of this response, I initially hypothesized that prenatal heat call exposure would act primarily through hypothalamic neuroendocrine reprogramming, given the central …
Attraction Of Nocturnal Scarab Beetles By Unusual Floral Volatiles In A Banksia (Proteaceae) With Functionally Diverse Pollinators, S. K. Wawrzyczek, B. Bohman, S. L. Krauss, I. M. Butler, G. R. Flematti, K. Farnier, S. E. Hoebee, R. A. Davis, R. D. Phillips
Attraction Of Nocturnal Scarab Beetles By Unusual Floral Volatiles In A Banksia (Proteaceae) With Functionally Diverse Pollinators, S. K. Wawrzyczek, B. Bohman, S. L. Krauss, I. M. Butler, G. R. Flematti, K. Farnier, S. E. Hoebee, R. A. Davis, R. D. Phillips
Research outputs 2022 to 2026
Pollination by beetles has evolved multiple times in flowering plants but with relatively few plant species adapted specifically to pollination by scarab beetles (Coleoptera: Scarabaeidae). However, some plant species may produce floral scents and offer floral rewards that attract scarabs alongside other pollinator functional groups. In Banksia attenuata (Proteaceae), nocturnal observations led to the discovery of extensive floral visitation by beetles, alongside birds, mammals and diurnal insects. Given the distinctive melon-like floral scent of B. attenuata, we predicted long-distance attraction of beetles by chemical cues. We undertook floral visitor surveys aided by camera traps and video recordings, and quantified insect …
The Rpm-1/Phr Signaling Hub Modulates Tau-Induced Neurodegeneration Through Regulation Of Microtubule Stability And Mapk Pathways In C. Elegans, Xinxing Ding
Theses and Dissertations
Neurodegenerative diseases, including Alzheimer's disease and frontotemporal dementia, are characterized by the accumulation of pathological tau proteins and progressive neuronal loss. Although research regarding tau-mediated toxicity is extensive, the specific pathology that determine whether neurons maintain homeostasis or succumb to collapse under tau-induced stress remain incompletely elucidated. A central, yet still insufficiently understood, feature of these diseases is the disruption of the microtubule (MT) cytoskeleton . The PHR protein family is evolutionarily highly conserved; within this family, RPM-1 in C. elegans functions as an intracellular signaling hub that regulates axon development, synapse formation, axon termination, and various microtubule-associated processes. This …
Aegic Blogposts - Grain Supply Chains, Ross Kingwell, Peter Elliott
Aegic Blogposts - Grain Supply Chains, Ross Kingwell, Peter Elliott
Grain and other field crops published reports
The Australian Export Grains Innovation Centre (AEGIC) was an independent, not-for-profit organisation established in 2012 by the Western Australian Government and the Grains Research and Development Corporation (GRDC). Its core mission was to increase the value and international competitiveness of Australia’s multibillion-dollar export grains industry. AEGIC ceased operation at the end of 2025.
Early in its history between 20 to 30 staff from the former Western Australian Department of Agriculture were seconded to AEGIC. Following the formation of DPIRD, AEGIC continued to receive substantial annual funding support from DPIRD.
This publication is a legacy document containing collated AEGIC blog posts …
Aegic Blogposts - Grain Pricing, Ross Kingwell, Peter Elliott, Chris Carter
Aegic Blogposts - Grain Pricing, Ross Kingwell, Peter Elliott, Chris Carter
Grain and other field crops published reports
The Australian Export Grains Innovation Centre (AEGIC) was an independent, not-for-profit organisation established in 2012 by the Western Australian Government and the Grains Research and Development Corporation (GRDC). Its core mission was to increase the value and international competitiveness of Australia’s multibillion-dollar export grains industry. AEGIC ceased operation at the end of 2025.
Early in its history between 20 to 30 staff from the former Western Australian Department of Agriculture were seconded to AEGIC. Following the formation of DPIRD, AEGIC continued to receive substantial annual funding support from DPIRD.
This publication is a legacy document containing collated AEGIC blog posts …
Aegic Blogposts - Grain Demand In Key Regions And Countries, Ross Kingwell, Sean Cowman, Peter Elliott, Chris Carter
Aegic Blogposts - Grain Demand In Key Regions And Countries, Ross Kingwell, Sean Cowman, Peter Elliott, Chris Carter
Grain and other field crops published reports
The Australian Export Grains Innovation Centre (AEGIC) was an independent, not-for-profit organisation established in 2012 by the Western Australian Government and the Grains Research and Development Corporation (GRDC). Its core mission was to increase the value and international competitiveness of Australia’s multibillion-dollar export grains industry. AEGIC ceased operation at the end of 2025.
Early in its history between 20 to 30 staff from the former Western Australian Department of Agriculture were seconded to AEGIC. Following the formation of DPIRD, AEGIC continued to receive substantial annual funding support from DPIRD.
This publication is a legacy document containing collated AEGIC blog posts …
Aegic Blogposts - Grain Demand Overview, Ross Kingwell, Paul Meibusch, Jorge E. Mayer, Richard Williams, Peter Elliott, Chris Carter
Aegic Blogposts - Grain Demand Overview, Ross Kingwell, Paul Meibusch, Jorge E. Mayer, Richard Williams, Peter Elliott, Chris Carter
Grain and other field crops published reports
The Australian Export Grains Innovation Centre (AEGIC) was an independent, not-for-profit organisation established in 2012 by the Western Australian Government and the Grains Research and Development Corporation (GRDC). Its core mission was to increase the value and international competitiveness of Australia’s multibillion-dollar export grains industry. AEGIC ceased operation at the end of 2025.
Early in its history between 20 to 30 staff from the former Western Australian Department of Agriculture were seconded to AEGIC. Following the formation of DPIRD, AEGIC continued to receive substantial annual funding support from DPIRD.
This publication is a legacy document containing collated AEGIC blog posts …
Aegic Blogposts - Grain Demand: Health And Environmental Issues, Ross Kingwell, Nicholas Thorsager, Chris Carter
Aegic Blogposts - Grain Demand: Health And Environmental Issues, Ross Kingwell, Nicholas Thorsager, Chris Carter
Grain and other field crops published reports
The Australian Export Grains Innovation Centre (AEGIC) was an independent, not-for-profit organisation established in 2012 by the Western Australian Government and the Grains Research and Development Corporation (GRDC). Its core mission was to increase the value and international competitiveness of Australia’s multibillion-dollar export grains industry. AEGIC ceased operation at the end of 2025.
Early in its history between 20 to 30 staff from the former Western Australian Department of Agriculture were seconded to AEGIC. Following the formation of DPIRD, AEGIC continued to receive substantial annual funding support from DPIRD.
This publication is a legacy document containing collated AEGIC blog posts …
Aegic Blogposts - Grain Industry Productivity, Ross Kingwell
Aegic Blogposts - Grain Industry Productivity, Ross Kingwell
Grain and other field crops published reports
The Australian Export Grains Innovation Centre (AEGIC) was an independent, not-for-profit organisation established in 2012 by the Western Australian Government and the Grains Research and Development Corporation (GRDC). Its core mission was to increase the value and international competitiveness of Australia’s multibillion-dollar export grains industry. AEGIC ceased operation at the end of 2025.
Early in its history between 20 to 30 staff from the former Western Australian Department of Agriculture were seconded to AEGIC. Following the formation of DPIRD, AEGIC continued to receive substantial annual funding support from DPIRD.
This publication is a legacy document containing collated AEGIC blog posts …
Quaking Aspen On Cedar Mountain, Utah: Status And Update, Jaycee Cappaert, Larissa L. Yocom, Paul C. Rogers, Darren J. Mcavoy, R. Justin Derose
Quaking Aspen On Cedar Mountain, Utah: Status And Update, Jaycee Cappaert, Larissa L. Yocom, Paul C. Rogers, Darren J. Mcavoy, R. Justin Derose
Wildland Resources Student Research
Quaking aspen forests are important communities in the western United States where they provide preferential food and habitat for animals, limit wildfires from spreading, and have favorable aesthetics, among other things. Their putative decline is an issue for ecology and management. We remeasured the aspen population on Cedar Mountain, Utah, to assess changes to its condition since it was originally measured in 2008 and laid the groundwork for continued aspen monitoring on Cedar Mountain. Our objectives were to compare current metrics of stand structure and composition, mortality, crown dieback, bole damage, regeneration, and recruitment, to those of the original inventory. …
Agent-Based Modeling Of Cellular Dynamics In Adoptive Cell Therapies, Yujia Wang
Agent-Based Modeling Of Cellular Dynamics In Adoptive Cell Therapies, Yujia Wang
Dissertations and Theses (Open Access)
Adoptive cell therapies (ACT) have shown promising progress in combating cancer, but clinical responses remain heterogeneous. Key determinants, including the functional states of infused cells, tumor–immune interactions, and dosing strategies, are difficult to resolve experimentally in the dynamic and heterogeneous tumor microenvironment, limiting optimization of ACT products and treatment regimens. To address the gap, we developed ABMACT (Agent-Based Model for Adoptive Cell Therapies), a computational framework that reconstruct key cellular functions, interactions, and molecular signatures to recapitulate cell population dynamics associated with differential treatment responses. ABMACT encodes autonomous “virtual cells” using literature-informed rules calibrated with experimental data, enabling simulation of …
Transcriptional Regulation In The Uterine Luminal Epithelium, Evelyn A. Carrion
Transcriptional Regulation In The Uterine Luminal Epithelium, Evelyn A. Carrion
Dissertations and Theses (Open Access)
Transcriptional Regulation in the Uterine Luminal Epithelium
Evelyn A. Carrion
Advisor: Richard R. Behringer, PhD
Abstract
The uterus is an organ comprised of multiple tissues that are essential for women’s health and reproduction. The uterus is composed of multiple tissue layers, including the perimetrium, myometrium, and the endometrium. The endometrium is the inner lining of the uterus, and contains the luminal epithelium, glandular epithelium, and stroma. The luminal epithelium is a simple columnar layer of cells that is necessary for embryo implantation. The uterus is derived in part from the embryonic precursor tissue called the Müllerian duct. There are no …