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Articles 1441 - 1470 of 114006
Full-Text Articles in Entire DC Network
Pkmζ-Kibra Interactions, Molecular Turnover, And Memory, Changchi Hsieh, David A Cano, Panayiotis Tsokas, James E Cottrell, André Antonio Fenton, Harel Shouval, Todd Charlton Sacktor
Pkmζ-Kibra Interactions, Molecular Turnover, And Memory, Changchi Hsieh, David A Cano, Panayiotis Tsokas, James E Cottrell, André Antonio Fenton, Harel Shouval, Todd Charlton Sacktor
Faculty, Staff and Student Publications
How can the molecules that strengthen synaptic connections maintain memory in the face of molecular turnover? Our previous work showed that persistent interaction between the postsynaptic scaffolding protein, KIBRA, and the autonomously active PKC isoform, PKMζ, is crucial for maintaining synaptic long-term potentiation (LTP) and memory lasting at least a month. This duration is longer than the lifespans of individual KIBRA and PKMζ molecules. Biophysical modeling of the interaction suggests oligomers of KIBRA-PKMζ dimers, but not individual dimers or monomers, can overcome molecular turnover by continuously incorporating newly synthesized KIBRA and PKMζ, replacing those that have degraded. Here we used …
Investigating Corollaries Between Streptococcus Gallolyticus Subsp. Gallolyticus Virulence And Colorectal Cancer, Tyler G. Myers
Investigating Corollaries Between Streptococcus Gallolyticus Subsp. Gallolyticus Virulence And Colorectal Cancer, Tyler G. Myers
Pursuit - The Journal of Undergraduate Research at The University of Tennessee
Streptococcus gallolyticus subsp. gallolyticus (Sgg) is a gram-positive, non-beta-hemolytic bacterium that belongs to the Lancefield group D of streptococcal pathogens. For the past several decades, associations between Sgg bacteremia and colorectal cancer (CRC) have been apparent, with gastroenterologists routinely recommending colonoscopies for positive cases of Sgg in either blood or stool samples. However, current research has not wholly established whether Sgg acts as a causative agent of CRC or if pre-existing cancers make the lumen of the colon more hospitable to its colonization. Regardless, Sgg has been implicated in the modulation of host inflammatory pathways and subsequent remodeling …
Cis-Regulatory Evolution Of Wnt Family Genes Contributes To A Morphological Difference Between Silkworm Species, Kenta Tomihara, Ana Pinharanda, Young Mi Kwon, Andrew M. Taverner, Laura S. Kors, Matthew L. Aardema, Julia C. Holder, Lin Poyraz, Takashi Kiuchi, Peter Andolfatto
Cis-Regulatory Evolution Of Wnt Family Genes Contributes To A Morphological Difference Between Silkworm Species, Kenta Tomihara, Ana Pinharanda, Young Mi Kwon, Andrew M. Taverner, Laura S. Kors, Matthew L. Aardema, Julia C. Holder, Lin Poyraz, Takashi Kiuchi, Peter Andolfatto
Department of Biology Faculty Scholarship and Creative Works
Closely related species often exhibit distinct morphologies that can contribute to species-specific adaptations and reproductive isolation. One example is Lepidopteran caterpillar appendages, such as the “caudal horn” of Bombycoidea moths, which have evolved substantial morphological diversity among species in this group. Using interspecific crosses, we identify the genetic basis of the caudal horn size difference between Bombyx mori and its closest relative Bombyx mandarina. The three largest of eight QTL account for one third the mean horn length difference between the species. The largest of these, on chromosome 4, encompasses a conserved Wnt family gene cluster, key upstream regulators …
Evaluating Eastern Wild Turkey (Meleagris Gallopavo Silvestris) Behavioral Ecology In The Southeastern United States, Chad Argabright
Evaluating Eastern Wild Turkey (Meleagris Gallopavo Silvestris) Behavioral Ecology In The Southeastern United States, Chad Argabright
LSU Doctoral Dissertations
The wild turkey (Meleagris gallopavo spp.) is a game bird species in North America who are one of the great success stories in restoration and conservation. Wild turkeys were extirpated from most of their range in the early 20th century, but through habitat restoration and translocation efforts the population was restored to the point of being sustainably harvested in 49 U.S. States by the late 20th century. However recent declines in wild turkey population indices have necessitated ongoing research on the behavioral ecology of wild turkeys to help counteract these declines. East Texas specifically for the past century has …
Moderate-Temperature Hydrothermal Treatment Removes Detectable Dna And Antibiotic Resistance Genes From Municipal Sludge While Preserving Resource Value, R Sean Norman M.Sc., Ph.D., Mirza Isanovic, Gabrielle Kartzmark, Nicole Berge
Moderate-Temperature Hydrothermal Treatment Removes Detectable Dna And Antibiotic Resistance Genes From Municipal Sludge While Preserving Resource Value, R Sean Norman M.Sc., Ph.D., Mirza Isanovic, Gabrielle Kartzmark, Nicole Berge
Faculty Publications
Wastewater treatment plants (WWTPs) are key reservoirs of antibiotic resistance genes (ARGs), with municipal sludge containing high bacterial densities and diverse ARGs that may spread through land application. Hydrothermal treatment (HT) is a process that inactivates pathogens and stabilizes biomass, but its performance at moderate temperatures is less understood. We evaluated HT (100°C–250°C; 2–24 h) for degrading bacterial DNA and ARGs in dewatered municipal sludge. DNA was quantified by fluorometry, bacterial presence confirmed by 16S rRNA gene PCR, and ARGs profiled by qPCR targeting 84 clinically and environmentally relevant genes. HT up to 250°C produced modest carbon densification, high solids …
Moderate-Temperature Hydrothermal Treatment Removes Detectable Dna And Antibiotic Resistance Genes From Municipal Sludge While Preserving Resource Value, R. Sean Norman, Mirza Isanovic, Gabrielle Kartzmark, Nicole Berge
Moderate-Temperature Hydrothermal Treatment Removes Detectable Dna And Antibiotic Resistance Genes From Municipal Sludge While Preserving Resource Value, R. Sean Norman, Mirza Isanovic, Gabrielle Kartzmark, Nicole Berge
Faculty Publications
Wastewater treatment plants (WWTPs) are key reservoirs of antibiotic resistance genes (ARGs), with municipal sludge containing high bacterial densities and diverse ARGs that may spread through land application. Hydrothermal treatment (HT) is a process that inactivates pathogens and stabilizes biomass, but its performance at moderate temperatures is less understood. We evaluated HT (100°C–250°C; 2–24 h) for degrading bacterial DNA and ARGs in dewatered municipal sludge. DNA was quantified by fluorometry, bacterial presence confirmed by 16S rRNA gene PCR, and ARGs profiled by qPCR targeting 84 clinically and environmentally relevant genes. HT up to 250°C produced modest carbon densification, high solids …
The Wildlife Intelligence For Aviation Safety (Wild-Ai), Bao Khoa Tran
The Wildlife Intelligence For Aviation Safety (Wild-Ai), Bao Khoa Tran
Student Research Symposium (SRS)
Wildlife strikes pose a significant safety risk and economic burden to the aviation industry. Over 291,000 strikes have been reported in the U.S. since 1990, causing an estimated $248 million in annual losses. The Wild-AI (Wildlife Intelligence for Aviation Safety) project leverages cutting-edge technologies, including large language models (LLMs), machine learning (ML), explainable AI (XAI), and Unmanned Air Vehicles (UAV) imagery, to enhance wildlife hazard management at airports. Wild-AI transforms traditional Wildlife Hazard Assessments (WHAs) by integrating advanced data analytics and UAV monitoring. By utilizing historical wildlife-strike data and ML algorithms, we will identify key predictors of damaging strikes, such …
Dual Phagocytosis-Checkpoint Blockade Revitalizes Immune Surveillance In Mouse Models Of Glioblastoma, Jonghoon Ha, Yifan Wang, Yifan Ma, Annette Wu, Shiyan Dong, Seong Dong Jeong, Jared L Edwards, Mengyu Chang, Yen-Tzu Chang, Xiaotian Wang, Maurice Dufilho, Michelle Najarro Torres, Shannon Mccabe, Weiye Deng, Adam J Grippin, Jeffrey S Weinberg, Shaan M Raza, Franco Demonte, Ian E Mccutcheon, Sujit Prabhu, Sherise D Ferguson, Chibawanye I Ene, Kadir Akdemir, Sreyashi Basu, Sonali Jindal, Benjamin R Schrank, Jian Hu, Sangeeta Goswami, Vinay K Puduvalli, Frederick F Lang, Kristin Huntoon, Padmanee Sharma, Betty Y S Kim, Wen Jiang
Dual Phagocytosis-Checkpoint Blockade Revitalizes Immune Surveillance In Mouse Models Of Glioblastoma, Jonghoon Ha, Yifan Wang, Yifan Ma, Annette Wu, Shiyan Dong, Seong Dong Jeong, Jared L Edwards, Mengyu Chang, Yen-Tzu Chang, Xiaotian Wang, Maurice Dufilho, Michelle Najarro Torres, Shannon Mccabe, Weiye Deng, Adam J Grippin, Jeffrey S Weinberg, Shaan M Raza, Franco Demonte, Ian E Mccutcheon, Sujit Prabhu, Sherise D Ferguson, Chibawanye I Ene, Kadir Akdemir, Sreyashi Basu, Sonali Jindal, Benjamin R Schrank, Jian Hu, Sangeeta Goswami, Vinay K Puduvalli, Frederick F Lang, Kristin Huntoon, Padmanee Sharma, Betty Y S Kim, Wen Jiang
Faculty, Staff and Student Publications
Macrophage-mediated phagocytosis of tumor cells elicits potent antitumor immunity. Nonetheless, sole-blockade of the anti-phagocytosis molecule CD47 has yielded insufficient therapeutic outcomes. Here, we report that glioblastoma (GBM) cells expressed abundant levels of phagocytosis checkpoint CD24. We further show that dual blockade of CD24 and CD47 synergistically enhances the pro-phagocytic activity of macrophages, thereby improving tumor antigen cross-presentation and activating the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway. This innate immune activation facilitates T cell infiltration into tumors and sensitizes tumors to anti-PD1 therapy, improving survival outcomes in murine GBM models, including immunosuppressive tumors reflecting human GBM-like features. Thus, our …
Microrna-625-3p Increases Chemosensitivity In Ovarian Cancer Cells Through Decreasing Ssx2ip-Mediated Cisplatin Export In Extracellular Vesicles, Chi-Lam Au-Yeung, Tetsushi Tsuruga, Marina A Talor, Yadira J Pacheco, Guangan He, Zahid H Siddik, Byeong J Cha, Suet-Ying Kwan, Kwong-Kwok Wong, Kay-Pong Yip, Samuel C Mok
Microrna-625-3p Increases Chemosensitivity In Ovarian Cancer Cells Through Decreasing Ssx2ip-Mediated Cisplatin Export In Extracellular Vesicles, Chi-Lam Au-Yeung, Tetsushi Tsuruga, Marina A Talor, Yadira J Pacheco, Guangan He, Zahid H Siddik, Byeong J Cha, Suet-Ying Kwan, Kwong-Kwok Wong, Kay-Pong Yip, Samuel C Mok
Faculty, Staff and Student Publications
Introduction: Advanced-stage high-grade serous ovarian cancer (HGSC) is a disease that is difficult to manage due to its heterogeneous clinical behavior. No reliable prediction of response to chemotherapy is currently available and the overall survival rate remains poor. Herein, we sought to determine the molecular mechanisms by which microRNAs (miRNAs) confer chemoresistance in ovarian cancer and demonstrate the efficacy of targeting miRNAs to sensitize HGSC to cisplatin treatment.
Methods: Next-generation miRNA sequencing was performed using microdissected HGSC specimens to identify an miRNA signature for intrinsic chemoresistance, and miR-625-3p was selected for further study. The effects of miR-625-3p on cisplatin sensitivity …
Waste-To-Energy Innovations And Advances In Hydrothermal Carbonization, Microwave, And Pyrolysis Processes: A Review, Ali Mohammed Saleh, Noah Mohammed Saleh, Mahmod A. Abdulqader, Hadi Hamdi Mahdi, Jafar Keighobadi, Omar K. Ahmed, Khalil Farhan Yassin, Azil Bahari Bin Alias, Omar Abed Habeeb, Ibrahim Awad Mohammed
Waste-To-Energy Innovations And Advances In Hydrothermal Carbonization, Microwave, And Pyrolysis Processes: A Review, Ali Mohammed Saleh, Noah Mohammed Saleh, Mahmod A. Abdulqader, Hadi Hamdi Mahdi, Jafar Keighobadi, Omar K. Ahmed, Khalil Farhan Yassin, Azil Bahari Bin Alias, Omar Abed Habeeb, Ibrahim Awad Mohammed
AUIQ Complementary Biological System
The accelerating global generation of municipal solid waste, coupled with escalating energy demands, presents one of the most pressing sustainability challenges of the 21st century. Conventional waste disposal pathways, such as landfilling and incineration, exacerbate environmental degradation and resource loss. In response, thermochemical technologies—specifically hydrothermal carbonization (HTC), microwave-assisted processing, and pyrolysis—have emerged as promising strategies for waste valorization and renewable energy recovery. This review critically examines recent advancements in these technologies, emphasizing their roles in converting diverse waste streams into high-value energy carriers and carbon-rich materials. Comparative analysis reveals that HTC operates efficiently under subcritical water conditions, producing hydrochar with …
The Sentience Of The Horse And The Philosophy Of Natural Horsemanship: Implications For Hrd Leadership, Rob E. Carpenter
The Sentience Of The Horse And The Philosophy Of Natural Horsemanship: Implications For Hrd Leadership, Rob E. Carpenter
Human Resource Development Faculty Publications and Presentations
This paper advances a biologically grounded philosophy of leadership through the lens of Natural Horsemanship. It reframes leadership as an embodied, sentient process rather than a purely cognitive or behavioral construct. Drawing from neuroscience, affective biology, sociology, and human resource development (HRD), it proposes that the horse–human relationship provides a living model for relational intelligence. The horse’s exquisite attunement to human emotion—mediated through limbic regulation and bio-behavioral synchrony—reveals that influence arises not from authority but from coherence. Leadership, like horsemanship, is a reciprocal act of co-regulation in which trust, safety, and communication are revealed through physiology before language. By examining …
Habitat And Conditions Of Poisoning Of Toxic Plants In North America, Michael H. Ralphs
Habitat And Conditions Of Poisoning Of Toxic Plants In North America, Michael H. Ralphs
Poisonous Plant Research (PPR)
This paper presents a list of important poisonous plants in North America that are toxic to both livestock and humans. The aim of this paper is to present information to help reduce the risk of poisoning. The paper emphasizes the particular plant communities in which these plants grow. Some of these plants are endemic, growing on specific soils or specific ecological sites. Others are distributed more broadly throughout a vegetation type. A few of the plants are widespread, ranging over several broad ecosystems. In diagnosing poisoning, it is important to know what plants are expected to grow in the communities …
Michigan Tech’S Insect Collection: An Important Historical Resource In The Upper Peninsula, Thomas E. Panella, Tara L. Bal
Michigan Tech’S Insect Collection: An Important Historical Resource In The Upper Peninsula, Thomas E. Panella, Tara L. Bal
The Great Lakes Entomologist
Regional insect collections can be valuable resources when covering under-represented areas, unique time periods, or unique collectors. Houghton and Baraga County Michigan are two predominantly forested counties in the Upper Peninsula (UP) of Michigan. The main campus for Michigan Technological University is based in Houghton, MI with a forestry field campus in Baraga County that was acquired in 1954. The university has had forest entomology research in some capacity at least since the 1930’s with faculty, students, and members of the community preserving and submitting various specimens in the decades since then, making it a unique collection demographically. The collection …
Dawn To Dusk Division Of Monarda Fistulosa Foraging Time By Bumble Bee Species (Bombus Spp.) And Likelihood To Return The Next Day, Elise Bernstein, Clara Costello, Mary Yang, Rosa Weinand, Noah Sullivan, Maya Cintorino, Charlie Vang, Miller Johnson, Ahmed Hussein, Gaochong Vang, Rashad Bowen, Kristen Gresl, Elaine Evans
Dawn To Dusk Division Of Monarda Fistulosa Foraging Time By Bumble Bee Species (Bombus Spp.) And Likelihood To Return The Next Day, Elise Bernstein, Clara Costello, Mary Yang, Rosa Weinand, Noah Sullivan, Maya Cintorino, Charlie Vang, Miller Johnson, Ahmed Hussein, Gaochong Vang, Rashad Bowen, Kristen Gresl, Elaine Evans
The Great Lakes Entomologist
There is a growing public interest in increasing pollinator habitat in urban areas. Monarda fistulosa is a commonly planted perennial species chosen for pollinator habitats of various sizes, from residential gardens to large-scale prairie restoration projects. Previous research has confirmed a preference for M. fistulosa among various bee species. We monitored and marked bumble bees visiting M. fistulosa over a 14-hour period, seeking to understand the daily pattern of bee visitation. We also observed bumble bees on the following day to determine the probability of marked individual bumble bees continuing to forage on M. fistulosa or to switch to a …
Initial Changes In Ground Beetle (Coleoptera: Carabidae) Species Assemblages Near Seasonal Ponds Surrounded By Forests Under Different Harvesting Practices, Robert A. Haack, Toby Petrice, Robert E. Acciavatti, Robert L. Davidson, Brian J. Palik
Initial Changes In Ground Beetle (Coleoptera: Carabidae) Species Assemblages Near Seasonal Ponds Surrounded By Forests Under Different Harvesting Practices, Robert A. Haack, Toby Petrice, Robert E. Acciavatti, Robert L. Davidson, Brian J. Palik
The Great Lakes Entomologist
Seasonal ponds often form after spring snowmelt in forests of the Great Lakes region. Although such seasonal ponds are common, few US states set buffer-width guidelines to protect them when harvesting the adjacent upland forest. The objectives of this study were to determine if the carabid beetle assemblages near seasonal ponds differed from those in the adjacent upland forests prior to any logging, and then if these assemblages changed in response to various levels of tree harvesting within and adjacent to the 15-m-wide buffers that surrounded the seasonal ponds. The traps were placed within the buffers at about 7.6 m …
Biology, Phenology, And Host Range Of A Seed-Feeding Weevil, Ceutorhynchus Constrictus (Coleoptera: Curculionidae), A Biological Control Agent For Garlic Mustard, Alliaria Petiolata, In North America, Ghislaine Cortat, Hariet L. Hinz, Esther Gerber, Elizabeth J. Katovich, Mary E. Marek-Spartz, Roger L. Becker, Robert S. Bourchier, Danielle Fife
Biology, Phenology, And Host Range Of A Seed-Feeding Weevil, Ceutorhynchus Constrictus (Coleoptera: Curculionidae), A Biological Control Agent For Garlic Mustard, Alliaria Petiolata, In North America, Ghislaine Cortat, Hariet L. Hinz, Esther Gerber, Elizabeth J. Katovich, Mary E. Marek-Spartz, Roger L. Becker, Robert S. Bourchier, Danielle Fife
The Great Lakes Entomologist
Ceutorhynchus constrictus Marsham is a seed-feeding weevil and potential biocontrol agent of the invasive plant garlic mustard, Alliaria petiolata (Bieb.) Cavara & Grande (Brassicaceae), in North America. Ceutorhynchus constrictus is native to Europe, has a single generation per year and eggs are laid into developing seeds within the seedpods of bolting garlic mustard plants. Females use their prolonged rostrum to bore holes through seedpods into the developing seed, deposit a single egg and then cover the opening with secretion. Larvae feed on ripening seeds and progress through three instars before exiting seedpods in late June, to pupate and overwinter in …
Full Issue For Tgle Vol. 58 Nos. 3 & 4
Full Issue For Tgle Vol. 58 Nos. 3 & 4
The Great Lakes Entomologist
Full issue for TGLE Vol. 58 Nos. 3 & 4
Freshwater Quality For Recreation, Heather Nix, Masha Bokar
Freshwater Quality For Recreation, Heather Nix, Masha Bokar
Forestry and Natural Resources
South Carolina has many water resources that provide tremendous opportunities for people to enjoy water-based recreational activities, such as swimming, boating, and fishing. Participation in these activities produces significant economic benefits and supports many jobs throughout the state. However, at times, water quality may be unsafe for immersion or skin contact due to high levels of pollutants, such as bacteria or cyanotoxins. It is important for people to be aware of potential concerns and understand methods for determining if a waterbody’s current conditions are likely to be safe for primary or secondary recreation.
Jackfruit Peel Valorization Through An Integrated Biorefinery Approach, Rohil Kumar K Mr
Jackfruit Peel Valorization Through An Integrated Biorefinery Approach, Rohil Kumar K Mr
Theses and Dissertations
Jackfruit (Artocarpus heterophyllus) peel (JFP), an abundantly available lignocellulosic biomass, remains largely underutilized despite being rich in cellulose, hemicellulose, lignin, and pectin. In India, approximately 13,460 hectares are under jackfruit cultivation, with Panruti in Tamil Nadu as a major production zone. The discarded peel often contributes to environmental pollution and greenhouse gas emissions. The present study emphasizes sustainable valorization of JFP through an integrated biorefinery framework for generating value-added bioproducts.
Major biopolymers, cellulose, hemicellulose, lignin, and pectin were extracted and fractionated, followed by detailed physicochemical characterization using FTIR, NMR, XRD, SEM, TGA, DSC, GPC, and BET analyses. Pectin extraction with …
Ectopic B Lymphocyte Follicles Exacerbate Ischemic Brain Damage Via Mif-Cd74/Cxcr4 And Interferon Signaling, Sheng Yang, Hang Zhang, Lu-Lu Xu, Luo-Qi Zhou, Yun-Hui Chu, Lian Chen, Xiao-Wei Pang, Lu-Yang Zhang, Li-Fang Zhu, Ming-Hao Dong, Ke Shang, Jun Xiao, Long-Jun Wu, Wei Wang, Dai-Shi Tian, Chuan Qin
Ectopic B Lymphocyte Follicles Exacerbate Ischemic Brain Damage Via Mif-Cd74/Cxcr4 And Interferon Signaling, Sheng Yang, Hang Zhang, Lu-Lu Xu, Luo-Qi Zhou, Yun-Hui Chu, Lian Chen, Xiao-Wei Pang, Lu-Yang Zhang, Li-Fang Zhu, Ming-Hao Dong, Ke Shang, Jun Xiao, Long-Jun Wu, Wei Wang, Dai-Shi Tian, Chuan Qin
Faculty, Staff and Student Publications
Neuroinflammation, encompassing both innate and adaptive immune responses, plays a crucial role in ischemic stroke. Although B lymphocytes are central to adaptive immunity, their contributions to ischemic stroke remain poorly understood. Here, we demonstrated that B lymphocytes accumulate in ischemic lesions, forming germinal center-like structures at the later stage after stroke, which mainly depended on in situ proliferation. This accumulation correlated with worsened neuroinflammation and ischemic injury, whereas B cell depletion reduced chronic brain damage during stroke. Mechanistically, microglia recruited B cells into ischemic lesions through MIF-CD74/CXCR4 signaling during the early phase of stroke, while IFN-related pathways in B cells …
Biomechanical Characterization Of Porcine Lower Limb Arteries For Preclinical Evaluation Of Peripheral Vascular Devices, Barbara Batista De Oliveira, Frazer Heinis, Anastasia Desyatova, Jason Mactaggart, Alexey Kamenskiy
Biomechanical Characterization Of Porcine Lower Limb Arteries For Preclinical Evaluation Of Peripheral Vascular Devices, Barbara Batista De Oliveira, Frazer Heinis, Anastasia Desyatova, Jason Mactaggart, Alexey Kamenskiy
Journal Articles
Purpose Peripheral artery disease (PAD) predominantly affects the lower extremities, where complex biomechanical deformations during limb flexion contribute to disease progression and treatment failure. While human and cadaver studies have characterized these deformations, preclinical device testing requires large-animal models that replicate human arterial anatomy and biomechanics. Swine are commonly used, yet their biomechanical comparability to humans remains poorly defined. Methods We performed a detailed morphometric and biomechanical analysis of the external iliac (EIA), superficial femoral (SFA), and popliteal (PA) arteries in 20 Yucatan and 16 domestic swine using computed tomography angiography. Arteries were evaluated in straight and flexed limb postures …
Poly(Adp-Ribose) Glycohydrolase Enforces P21 Degradation Via Deparylation To Promote Gastric Cancer Progression, Yangchan Hu, Qimei Bao, Yixing Huang, Yan Wang, Xin Zhao, Junjun Nan, Yuxin Meng, Mingcong Deng, Yuancong Li, Zirui Zhuang, Hanyi He, Dan Zu, Yuke Zhong, Chunkai Zhang, Bing Wang, Ran Li, Yanhua He, Qihan Wang, Min Liu, John A Tainer, Yin Shi, Xiangdong Cheng, Ji Jing, Zu Ye
Poly(Adp-Ribose) Glycohydrolase Enforces P21 Degradation Via Deparylation To Promote Gastric Cancer Progression, Yangchan Hu, Qimei Bao, Yixing Huang, Yan Wang, Xin Zhao, Junjun Nan, Yuxin Meng, Mingcong Deng, Yuancong Li, Zirui Zhuang, Hanyi He, Dan Zu, Yuke Zhong, Chunkai Zhang, Bing Wang, Ran Li, Yanhua He, Qihan Wang, Min Liu, John A Tainer, Yin Shi, Xiangdong Cheng, Ji Jing, Zu Ye
Faculty, Staff and Student Publications
Dysregulation of cell cycle checkpoints is a cancer hallmark, with ubiquitination-controlled protein stability playing a pivotal role. Although p21, a key cyclin-dependent kinase inhibitor, is tightly regulated by ubiquitin-mediated degradation, the key upstream modulators of its ubiquitination remain incompletely defined. Here, we identify poly(ADP-ribose) glycohydrolase (PARG) as a regulator of p21 stability in gastric cancer (GC) cells. We show that PARG expression is markedly upregulated in GC tissues and correlates with poor patient prognosis. Functional assays revealed that genetic depletion of PARG triggers G2/M phase arrest and impairs GC cell proliferation. Mechanistically, we demonstrate that PARG loss enhances p21 PARylation, …
Mechanometabolism Instructs Hematopoietic Stem Cell Specification, Paulina D Horton, Alina Syed, Michelle Winkler, Abishek B Vaidya, Michael Rariden, Neha Arora, Yong Zhou, Michihiro Kobayashi, Momoko Yoshimoto, Hyun Jung Lee, Hyun-Eui Kim, John P Hagan, Catherine Denicourt, Travis I Moore, Pamela L Wenzel
Mechanometabolism Instructs Hematopoietic Stem Cell Specification, Paulina D Horton, Alina Syed, Michelle Winkler, Abishek B Vaidya, Michael Rariden, Neha Arora, Yong Zhou, Michihiro Kobayashi, Momoko Yoshimoto, Hyun Jung Lee, Hyun-Eui Kim, John P Hagan, Catherine Denicourt, Travis I Moore, Pamela L Wenzel
Faculty, Staff and Student Publications
Mechanical force generated by blood flow stimulates emergence of the first hematopoietic stem cells (HSCs) that populate the blood system. Force drives the transition of HSC precursors from an endothelial to hematopoietic identity, yet the molecular regulation of this fate switch remains poorly understood. We report that shear stress triggers adaptation in mitochondrial composition, ultrastructure, and function, which are essential for hematopoietic fate and engraftment potential. Shear stress remodels mitochondria in hemogenic endothelium by promoting mitochondrial gene transcription and protein synthesis. Laminar flow selectively initiates translation of 5' terminal polypyrimidine (5'TOP) motif-containing transcripts, which commonly encode ribosome and translation machinery. …
Plaster Creek Watershed Management Plan: Chloride Addendum, Plaster Creek Stewards
Plaster Creek Watershed Management Plan: Chloride Addendum, Plaster Creek Stewards
Watershed Reports
This addendum complements the 2008 Plaster Creek Watershed Management Plan (WMP), which tells the full story of the Plaster Creek Watershed’s current condition, impairments, and need for restoration. This addendum focuses on chloride, an emerging pollutant of concern in Michigan that was not addressed in Plaster Creek’s 2008 WMP. This addendum meets the nine elements required by the United States Environmental Protection Agency (EPA) for a watershed management plan to be officially approved; as such, its content and layout are intended for a technical audience.
(Si16-21) Dynamical Study Of A Hassell-Varley Model With Nonlinear Harvesting And Fear Effect In Prey, Aditya Bhattacharya, Anindita Bhattacharyya
(Si16-21) Dynamical Study Of A Hassell-Varley Model With Nonlinear Harvesting And Fear Effect In Prey, Aditya Bhattacharya, Anindita Bhattacharyya
Applications and Applied Mathematics: An International Journal (AAM)
In this article, a one predator-one prey model incorporating Richards’ type growth in prey population, Hassell-Varley type functional response and Michaelis-Menten type prey harvesting is proposed and analyzed. Richards’ type growth with fear factor is incorporated in the proposed model to generalize the reduction effect of predator-induced fear on the rate of growth of the prey population. Positivity and boundedness of the system’s solutions are first established to ensure biological feasibility of the model. Existence and stability conditions of various types of equilibrium points associated with the model such as trivial equilibrium, axial (predator–free) equilibrium and coexistence equilibrium are obtained …
Circuit And Synaptic Mechanisms Of Methamphetamine Induced Cognitive Deficits During Abstinence: Roles Of The Perirhinal-Prefrontal Pathway And The Nucleus Reuniens, Sarah Goldsmith
MUSC Theses and Dissertations
Cognitive deficits during abstinence are a hallmark of methamphetamine (meth) use and indicative of negative treatment outcomes. In rats, both long access meth self-administration and meth binge produce recognition memory deficits due to drug-induced plasticity within the perirhinal cortex (PRH). PRH projections are numerous and include the medial prefrontal cortex (mPFC) and the Nucleus Reuniens (NRe). In the first study, the role of the PRH-mPFC reciprocal circuit in novel object recognition memory was investigated by infusing an rgAAV encoding GFP-tagged Cre recombinase into the PRH or the mPFC. Following surgery, rats explored objects. During exploration, PRH neurons receiving input from …
Species Sorting And Spatial Effects In Hyporheic Invertebrate Functional Groups, Benjamin T. Hutchins, Zoey B. Chanin, Kathryn E. Perez, Peter H. Diaz, Benjamin F. Schwartz
Species Sorting And Spatial Effects In Hyporheic Invertebrate Functional Groups, Benjamin T. Hutchins, Zoey B. Chanin, Kathryn E. Perez, Peter H. Diaz, Benjamin F. Schwartz
School of Integrative Biological & Chemical Sciences Faculty Publications
Invertebrate communities in the hyporheic zone are structured by metacommunity processes including environmental filtering and spatial effects (e.g., dispersal). We investigated how these processes differentially influence two functional groups: groundwater-obligate invertebrates (stygobionts) and benthic insects. We predicted that environmental filtering would dominate for insects, while spatial effects would prevail for stygobionts. We collected 76 samples from 28 hyporheic sites along 109 km of the Rio Grande, Texas, USA, enumerating 54,508 individuals across 80 taxa. Concordance analysis and RDA revealed two communities: one dominated by insects, and another by crustaceans and soft-bodied organisms, including all stygobionts. In linear models, insect richness …
Stemflow Dynamics In The Jamari National Forest (Brazilian Amazon): Ii. Solute Concentrations And Flux Dynamics, Jeferson Alberto De Lima, John T. Van Stan Ii, Karolina Lewińska, Agnieszka Dradrach, Jakub Ceglarek, Kelly Cristina Tonello
Stemflow Dynamics In The Jamari National Forest (Brazilian Amazon): Ii. Solute Concentrations And Flux Dynamics, Jeferson Alberto De Lima, John T. Van Stan Ii, Karolina Lewińska, Agnieszka Dradrach, Jakub Ceglarek, Kelly Cristina Tonello
Biological, Geological, and Environmental Faculty Publications
Trees can redirect large volumes of rainwater to the base of their stems. This stemflow not only redistributes water but also channels canopy-derived solutes to the forest floor. Building on research showing canopy geometry and bark properties govern stemflow volumes, we examined how those same traits modulate the biogeochemical side of this flux. Over a 12-month period in Jamari National Forest (Brazil), we quantified stemflow volume and solute chemistry for 19 trees grouped by diameter at breast height (D: < 10, 10-20 and > 20 cm), crown area (CA: < 30, 30-60 and > 60 m(2)) and bark texture (smooth, fissured and rough). Small-stemmed, smooth-barked trees produced the greatest stemflow …
The Emerging And Evolving Evidence Supporting Creatine As An Ergogenic Aid: History And Applications, Chad Kerksick, Drew Gonzalez, Jeffrey Stout, Scott Forbes, Darren Candow, Tim Ziegenfuss, Ronald Marshall, René Schwesig, Richard Kreider
The Emerging And Evolving Evidence Supporting Creatine As An Ergogenic Aid: History And Applications, Chad Kerksick, Drew Gonzalez, Jeffrey Stout, Scott Forbes, Darren Candow, Tim Ziegenfuss, Ronald Marshall, René Schwesig, Richard Kreider
Faculty Scholarship
Background
Creatine is one of the most extensively studied ergogenic aids, with over three decades of research supporting its role in exercise performance, recovery, and health.
Methods
This narrative review summarizes the historical development of creatine supplementation and evaluates evidence regarding its mechanisms, efficacy across active, athletic populations (e.g. strength, endurance, team-sport), and tactical (e.g. military, law enforcement) populations, and its safety profile.
Results
The evidence suggests that creatine enhances phosphocreatine resynthesis and cellular energy availability, resulting in consistent improvements in high-intensity exercise performance, training adaptations, lean body mass, strength, and power. Additional findings indicate that creatine may attenuate exercise-induced …
Improvements To Fisheries Compensation Processes And Valuation Methodologies In Western Australia, Department Of Primary Industries And Regional Development, Western Australia
Improvements To Fisheries Compensation Processes And Valuation Methodologies In Western Australia, Department Of Primary Industries And Regional Development, Western Australia
Fisheries Published Reports
This report has been prepared by the Compensation Working Group (WG) to provide advice to the Minister for Fisheries on improving Western Australia’s (WA) fisheries compensation processes under two key legislative frameworks:
- Fisheries adjustment schemes, under the Fisheries Adjustment Scheme Act 1987
- (FAS Act), and
- Statutory compensation under Fishing and Related Industries Compensation (Marine Reserves) Act 1997 (FRICMA).
This work has been undertaken as a precursor to the larger scale adjustment and compensation processes that will be required as part of the implementation of several marine parks throughout the Kimberley and South Coast of WA.