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Ethnobotanical Study Of Medicinal Plants Used By The Local Population In And Around Kozak Plateau (Bergama, İzmir, Türkiye), Şükrü Arasan, Hasan Yildirim

Turkish Journal of Botany

This research was conducted between 2020 and 2022 in 21 villages located on the Kozak Plateau and its surroundings, in the Bergama district of İzmir province, Türkiye. The main aim of the study is to document the medicinal uses of plants by the local population and to contribute to the preservation and transmission of ethnobotanical knowledge—passed down through generations— to future generations before it disappears. Interviews were conducted with 159 informants, and the traditional medicinal uses of 126 plant taxa belonging to 54 families were identified. Among these, the therapeutic uses of 37 taxa were recorded for the first time. …

Insights Into The Role Of Sox6 In The Developing Heart, Hannah Tarolli

MUSC Theses and Dissertations

Approximately 40,000 babies born each year in the U.S. have a congenital heart defect (CHD). However, only a small percentage of CHDs has a known genetic cause, highlighting the need for research surrounding heart development and the pathogenesis of CHDs. Heart development research aims to elucidate the precise coordination of gene expression and cell signaling with the goal of advancing prevention and treatment methods. During heart development, cells from several origins play a crucial role. This includes cells derived from the endocardium, epicardium, cardiac neural crest, and second heart field. Previous studies have revealed that the transcription factor, SOX9, is …

Determination Of High-Temperature Stress Tolerance In Strawberry Varieties Based On Physiological And Biochemical Mechanisms, Izhar Ullah, Hüsnü Demi̇rsoy, Musa Kavas, Kubi̇lay Yildirim, Leyla Demi̇rsoy

Turkish Journal of Botany

Rising global temperatures due to climate change threaten optimal strawberry growth and sustainable yields. Limited data exist on the physiological and biochemical responses of strawberry cultivars to high-temperature stress and their tolerance mechanisms. T his study evaluated the responses of 21 day-neutral and short-day strawberry cultivars to high-temperature stress and classified their tolerance levels using a novel weighted rating method. Plants were grown in 15-cm plastic pots (3:1:1 garden soil, peat, perlite) under open-field conditions until the 3–4 leaf stage and then transferred to climate chambers. After acclimatization at 25/15 °C (day/night) for 2 weeks, the plants were subjected to …

Comparison Of Heavy Metal Accumulation In Soil And Wood Core Within Tallassee And Tuskegee, Alabama, Alicia R. Wilson, Brianna Smith, Latricia Miller, Rashidah Farid

Professional Agricultural Workers Journal

Heavy metals are natural components of the environment and can be relatively non-impactful in low concentrations. However, high concentrations of heavy metal toxicity can result in air, water, and soil contamination that adversely impacts environmental, human, and wildlife health. This study focuses on detecting the presence of heavy metals in soil, Loblolly Pine tree bark, and wood core samples from sites near a landfill in the Tallassee, Alabama, community and a post-agricultural site in Tuskegee, Alabama. It has been hypothesized that heavy metals are present in soil, tree bark, and the tree’s wood core from sampling sites. Samples were taken …

Synthetic Lethality Between Rb-Loss And E2f3 Inhibition In Small Cell Cancers Targeted By Pyrimidine Synthesis Blockade, Evan R. Abt, Liang Wang, Grigor Varuzhanyan, Jack Freeland, Tian He, Guadalupe M. Peña-Garcia, Lauryn Ruegg, Jami Mclaughlin, Donghui Cheng, Nikolas G. Balanis, Chia-Chun Chen, Yang Xu, Yi Xing, Sanaz Memarzadeh, Caius G. Radu, Thomas G. Graeber, Owen N. Witte

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Small cell carcinoma is a highly lethal cancer variant often found with neuroendocrine (NE) features, as exemplified by small cell lung cancer and small cell NE prostate cancer (SCPC). A genome-wide CRISPR dependency screen using SCPC models generated through human prostate cell transformation identifies a requirement for the transcription factor E2F3. E2F3 dependency is linked to RB inactivation, a near universal occurrence across small cell cancers. The requirement for E2F3 is shared by RB-deficient cells originating from the prostate, lung, and adnexa. In RB-deficient cancer cells, E2F3 inhibition restrains cell cycle progression, proliferation, and tumor growth in vivo. Inhibition of …

Transcriptome Profiling Of Silique Lncrnas Reveals Novel Insights Into Silique Length In Radish (Raphanus Sativus L.), Xiaomin Yu, Yuxin Zhu, Zhoubo Guan, Shisheng Li

Turkish Journal of Botany

Radish is a widely cultivated vegetable with known medicinal value and produces siliques that differ significantly in number and size. The present study compares normal Duanye-13 radish (CK-type) siliques with mutant radish siliques induced by chemical mutagenesis at the young (YS), short (SS), and long (LS) silique stages. Differences in long noncoding ribonucleic acid (lncRNA) expression were investigated using high-throughput RNA sequencing and bioinformatic analyses, revealing 45 324 new lncRNAs in radish siliques. lncRNA expression was higher in YS and LS mutant lines than in CK-type lines, and expression in SS mutants tended to be lower than in CK-type lines. …

Genome-Wide Crispr Screen Identifies A Cytokine-Enhancer Circuit Driving Hif-2Α Activation In Renal Cancer, Jun Fang, Jeremy M Simon, Tao Wang, Yunpeng Gao, Xianju Bi, Lianxin Hu, Chengheng Liao, Cheng Zhang, Yayoi Adachi, Jin Zhou, Hongyi Liu, Qian Liang, James A Nathan, Ram Mani, James Brugarolas, Qing Zhang

Faculty, Staff and Student Publications

Resistance to HIF-2α inhibitors such as Belzutifan underscores the need to better understand how HIF-2α is transcriptionally regulated in clear cell renal cell carcinoma (ccRCC). Here, we uncover a cytokine-driven enhancer mechanism that sustains HIF-2α expression through the JAK1-STAT3 signaling pathway. Using a genome-wide CRISPR screen in VHL-deficient ccRCC cells, we identified SOCS3 as a key negative regulator of HIF-2α. Mechanistically, loss of SOCS3 activates JAK1-STAT3 signaling, leading to the recruitment of STAT3 to distal enhancers upstream of EPAS1 that physically loop to its promoter to drive HIF-2α transcription. This cytokine-enhancer circuit was recapitulated in ccRCC patient samples and functionally …

Bacteriophage Therapy For Antibiotic-Resistant Infections, Shiva Pariyar

Best Integrated Writing

Pariyar examines bacteriophage therapy as a promising alternative to antibiotics for treating multidrug-resistant infections, highlighting its targeted mechanism, ability to disrupt biofilms, and synergy with antibiotics. While challenges such as regulation, immune response, and limited clinical trials remain, the study argues that advances in biotechnology and global collaboration position phage therapy as a future cornerstone in combating antimicrobial resistance.

Tlr3 Mediated Type I Interferon Response In Mammalian Cell Defense Against Cryptosporidium Parvum Infection., Anjelica Matias

Biochemistry and Molecular Biology

Cryptosporidium parvum is a major cause of a diarrheal disease which affects many children in the USA as well as the rest of the world, yet the contribution of its double stranded RNA (dsRNA) viral symbiont, Cryspovirus (CSpV1) to host innate immunity remains unclear. This study investigated whether CSpV1 activates Toll Like Receptor 3 (TLR3) signaling pathways and downstream Interferon type I (IFN I) responses in mammalian intestinal epithelial cells. Confluent Human Ileocecal Colorectal Adenocarcinoma cells (HCT8) were exposed to CSpV1, and the expression levels of Tumor Necrosis Factor Receptor-Associated Factor 3 (TRAF3), Nuclear Factor-𝜅-light chain enhancer of activated B-cells …

Session Ia: Natural Sciences Presentation 1 - Elucidating Elimia: Affinities Of North Carolina Freshwater Snails, Andrew Wilson

Life of the Scholar Multidisciplinary Conference

Study of Pleuroceridae snail variation and evolutionary relationships.

Successful Treatment Of Juvenile Sterile Granulomatous Dermatitis And Lymphadenitis In A Pomeranian Aged 5 Months Using Topical Hydrocortisone Aceponate And Systemic Antibiotic, Nutjira Sawatmongkol, Sirada Tayayouth, Suttiwee Chermprapai

The Thai Journal of Veterinary Medicine

A 5-month-old intact male Pomeranian puppy was presented with a 2-week history of acutely swollen face, eyelids, lips, and muzzle. A physical examination revealed focal alopecia, folliculitis, and erythema on the muzzle, periocular, and perianal areas; crusts were also found around the muzzle. The puppy received monthly oral afoxolaner and milbemycin oxime. No ectoparasite was observed based on a trichogram test. Skin cytology revealed intracellular cocci and neutrophils. A skin biopsy taken from the muzzle revealed pyogranulomatous perifollicular dermatitis with epidermal spongiosis, intraepidermal pustules, and a superficial crust. This condition was diagnosed as juvenile cellulitis on the basis of age, …

Antibacterial Activity Of Sapium Ellipticum, Securidaca Longepedunculata, And Allophylus Africanus Against Drug-Resistant Pseudomonas Aeruginosa Isolates, Eleonora A. Mbare, Rose J. Masalu, Cyprian B. Mpinda

Tanzania Journal of Science

Pseudomonas aeruginosa poses a major clinical challenge due to its high levels of antibiotic resistance. This study evaluated the antibacterial activity of three medicinal plant extracts Allophylus africanus (leaves), Securidaca longepedunculata (root bark), and Sapium ellipticum (stem bark), against 30 drug-resistant P. aeruginosa isolates. Antibacterial screening was conducted using the agar well diffusion method, followed by determination of minimum inhibitory concentrations (MICs) via a 96-well microtiter plate assay. All three plant extracts demonstrated inhibitory activity against three resistant P. aeruginosa strains (gentamicin-resistant strains F4 and GR4RAU-AI, and ceftazidime-resistant strain 19-10), with inhibition zones of varying diameters. MIC values showed strain-specific …

Fenced And Feral: Farming And Spread Of Flowerhorn (Amphilophus Spp.) In Lake Sampaloc, Philippines, Janice A. Ragaza, Hannah Nicole Gasmen

Environmental Sustainability

This study examines the spread and ecological impact of invasive Flowerhorn cichlids (Amphilophus spp.) in Lake Sampaloc, Philippines, driven by both accidental release and intentional aquaculture practices. Field observations and literature reveal that these highly adaptable and aggressive fish outcompete native species, contributing to biodiversity decline amid increasing pollution, eutrophication, and microplastic contamination. Their phenotypic plasticity allows them to thrive in degraded environments, further exacerbating ecological imbalance. While local communities have begun utilizing Flowerhorns for ornamental trade and potential aquafeed production, such practices risk reinforcing their proliferation. The study highlights the need for integrated management strategies combining biosecurity, pollution control, …

Honey Bees (Apis Mellifera) Pollination Enhances Watermelon (Citrullus Lanatus) Yield In Kibaha Tanzania, Beatrice Tonola, Charles Olambo Joseph, Mkabwa L.K. Manoko, Shibonage K. Mashilingi

Tanzania Journal of Science

Honey bees are essential pollinators of the world’s food crops. However, information on the influence of honey bee pollination on watermelon yield is limited in Tanzania. This study assessed efficiency of honey bee pollination on watermelon yield. The study tested three improved watermelon varieties (Zebra F1, Candy F1 and Sukari F1) and three pollination environments: (Caged with Apis mellifera (CAM), Caged without insects (CW) and Open pollination (OP) in two seasons. The experiment was arranged in a split-plot design in randomized complete block design (RCBD) with three replications. Results showed no significant interaction between pollination environment and varieties. Significant difference …

Research Progress On Economic Impact Of Animal Diseases, Zhen Xu, Haizhao Zhang, Zizhong Shi, Hui Zhou, Xiangdong Hu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Animal diseases not only pose significant challenges to the stable development of related industries such as livestock farming but also adversely affect the broader economic and social landscape. This paper presents the reviews on the current state of research both domestically and internationally, systematically presenting the advancements of the economic impacts of animal diseases. The findings reveal that, (1) the economic impacts of animal diseases can be categorized into direct and indirect effects; however, a unified analytical framework has yet to be established. The “Epidemiology-Economics” approach is the primary analytical method for assessing the economic impacts of animal diseases. (2) …

Targeting Hypothalamic Oxidative Stress And Neuroinflammation: A Novel Neuroprotective Role For Annona Muricata Seed Extract In Aluminium- Induced Alzheimer-Like Neurodegeneration, O. A Bamgbose, O. D Akanji, P. B Fakunle, D. O Taiwo-Ola, K. O Odubela, E. O Olayemi, B. A Akanbi, B. M David

AUIQ Complementary Biological System

Alzheimer's disease (AD) is increasingly recognized as a multisystem neurodegenerative disorder involving oxidative stress and neuroinflammation beyond classical hippocampal pathology. The hypothalamus, a key regulator of metabolic and neuroendocrine homeostasis, remains comparatively underexplored in experimental AD models. This study investigated the effects of aqueous Annona muricata seed extract (SSE) on hypothalamic oxidative injury in an aluminium chloride (AlCl₃)-induced Alzheimer's disease–like model in Wistar rats. Adult Wistar rats of both sexes were randomly assigned to five groups (n = 5): control, AlCl₃ (100 mg/kg), SSE alone (200 mg/kg), AlCl₃ + SSE, and AlCl₃ + donepezil (10 …

Fire Scarring Does Not Significantly Impact Conifer Growth Response To Forest Fires In Utah, Connor B. Biser, Russell Torgersen, Otto Degroff, Steve Petersen

Student Works

BYU Wildfire Symposium 2026 - First Place Research Application, People's Choice Award

Wildfires are an increasingly prevalent disturbance in forests in the western United States, and play an essential role in ecosystem function. Micro-variations in fire dynamics and intensity can leave individual trees with varying levels of damage. We hypothesized that trees with fire-scars would suffer a growth depression directly following the disturbance. Core samples were taken for dendrochronological analysis from 185 conifers at 29 points, representing 11 fires from 6 years. Our findings showed a growth depression in the first year following the fire, with no significant difference between …

Audubon Society Minutes, W.A. Ginham

Documents

Minutes of the Audubon Society--October 7, 1931, in Wesleyan Hall. The second part of the meeting was noted on November 4, 1931.

Immunoregulatory Effects Of Choerospondias Axillaris (Roxb.) B.L.Burtt & A.W.Hill Fruit Extract In Mice With Insights On In Vitro Mechanism, Ravi Gautam, Anju Maharjan, Jaehee Lee, Sujeong Yang, Jihun Jo, Manju Acharya, Daeun Lee, Narayan Prasad Ghimire, Saroj Lamichhane, Byungsun Min, Changyul Kim, Hyoungah Kim, Yong Heo

Department of Microbiology and Immunology Faculty Papers

BACKGROUND: Lapsi (Choerospondias axillaris), a plant native to Nepal, has been traditionally used in Asian countries to treat cardiovascular conditions. However, its effects on immune regulatory function remain largely unexplored. This study aimed to in vivo evaluate the immunoregulatory properties of Lapsi fruit extract in mice on immunotoxic responses with analysis on in vitro mechanism for immune suppression, oxidative stress, and inflammatory response. Male Balb/c mice were intragastrically administered various doses of the extract for 21 days. In some mice, immune suppression was induced with cyclophosphamide, and subsequent immune recovery was assessed. In addition, RAW264.7 cells and THP-1-derived macrophages were …

Cover And Contents

Turkish Journal of Zoology

No abstract provided.

Nonnative Crayfish In Türkiye: Presence Records, Invasion Pathways, And Ecological Risks, Muzaffer Mustafa Harlioğlu

Turkish Journal of Zoology

The globalization of trade, aquaculture, and the ornamental pet industry has accelerated the transboundary movement of nonnative crayfish species, with significant ecological consequences. Türkiye, a biodiversity-rich country bridging Europe and Asia, has increasingly become a point of concern due to the rising presence of alien crayfish taxa introduced primarily via the aquarium trade and scientific research. This study investigates the presence records of nonnative crayfish species in Türkiye, identifies their likely introduction pathways, and outlines potential future outspread routes across the major freshwater basins of the country. Species such as Procambarus clarkii, Cherax quadricarinatus, C. albertisii, and Cambarellus patzcuarensis have …

Stage-Specific Growth Characteristics Of The Calanoid Copepod Invader Sinodiaptomus Sarsi​, Leonid Svetlichny, Kami̇l Mert Eryalçin, Melek İşi̇ni̇bi̇li̇r Okyar

Turkish Journal of Zoology

The population dynamics of the Asian invasive copepod Sinodiaptomus sarsi were  studied for four years after its introduction into an artificial pond in Kyiv (Ukraine) in  2020. The growth and development parameters of this species were measured under  laboratory conditions. From its first appearance in spring 2020, the abundance  of copepodite stages and adults increased from 3.5–5.2 individuals (ind.)  m–3 to 1057.8 ind. m–3 in June 2024, suggesting the successful establishment  of S. sarsi populations in this region. A characteristic feature of S.  sarsi development in ponds is a male-biased sex ratio in the later copepodite stages.  The sex ratio …

Morphometric And Reproductive Divergence Of Deep-Water Shrimps Plesionika Martia (A. Milne-Edwards, 1883) And P. Heterocarpus (A. Costa, 1871) Along A Depth Gradient In The Eastern Aegean Sea, Murat Özbek, Cengi̇z Koçak, Zafer Tosunoğlu

Turkish Journal of Zoology

This study provides a comparative analysis of two deep-water pandalid shrimp  species, Plesionika martia and P. heterocarpus, based on monthly samples collected  over one year in the Eastern Aegean Sea. Specimens were obtained from species-specific depth zones (550 m for P. martia and 350 m for P. heterocarpus) to examine  morphometric traits, sexual dimorphism, and reproductive patterns. A total of 4419  individuals were analyzed. Females were significantly larger and more abundant than  males (K–S test, p < 0.05), indicating pronounced sexual dimorphism. Length–weight relationships revealed negative allometric growth in both species, confirmed  by t-tests (p < 0.05). Reproductive activity differed markedly: P. martia showed a short  and distinct spawning period peaking in late autumn, whereas P. heterocarpus  displayed a prolonged, bimodal cycle with peaks in spring and summer. The gonadosomatic index (GSI) and the proportion of ovigerous females varied  significantly by season and species. A strong positive correlation between carapace  length and gonad weight was found, with a more linear relationship in P. martia and  greater variability in P. heterocarpus. Size at first maturity (L₅₀) was estimated at 22.3  mm CL for P. heterocarpus but could not be reliably determined for P. martia  due to limited small size data, likely reflecting ontogenetic depth segregation. The  consistent bathymetric separation between these species—also reported in the  Western Mediterranean—suggests ecological niche differentiation. Species-specific  management measures, including depth-based fishing restrictions and temporal  closures during reproductive peaks, are recommended to support the sustainable  exploitation of deep sea shrimp stocks in the region.

Frequencies And Roles Of Plants In The Diet Of Three Mesocarnivores (Canis Lupaster, Genetta Genetta, And Herpestes Ichneumon): Implications For Forest Regeneration In A North African Hot Spot (Algeria), Messaoud Bensidhoum, Abdelkrim Limane, Larbi Khifer, Ania Ben Ammar, Lylia Amrouche

Turkish Journal of Zoology

The Djurdjura National Park (PND, Algeria) is part of one of the world’s 36 biodiversity hot spots, recognised by the United Nations as a national biosphere  reserve. It contains the Darna primary forest, a key habitat for several mesocarnivore  mammals, including the golden wolf (Canis lupaster), the common genet (Genetta  genetta) and the ichneumon mongoose (Herpestes ichneumon). Although their diets  are primarily based on animal prey, these carnivores exhibit both qualitative and  quantitative reliance on plants, a pattern that merits thorough documentation. We  analysed 30 scats per species per month over four years (1440 scats per species).  More than 35% …

Species Identification Using Otolith Morphometry Of Four Gurnards (Family: Triglidae) From  Edremit Bay (Aegean Sea), Ahmet Mert Şenbahar, Di̇lek İlhan, Aydin Ünlüoğlu, Sencer Akalin

Turkish Journal of Zoology

Shape and size analyses of otoliths are widely considered appropriate tools for distinguishing between fish species and for assessing populations and stocks.  The present study aims to distinguish four gurnard species collected from Edremit  Bay (Aegean Sea) based on variations in their otolith shape morphology. A total of 60  specimens of Eutrigla gurnardus, 64 of Chelidonichthys lastoviza, 60 of  Chelidonichthys lucerna, and 60 of Lepidotrigla cavillone were analyzed. No  significant intraspecific differences were noted in the morphology of the left and right  otoliths, and so only the left sagittal otoliths were subjected to further analysis. Otolith  shape was quantified using …

Spiny Dogfish (Sqaulus Acanthias) Jaw, Courtney R. Schober, Sophia R. Oliveira, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

Latest Sightings Of The Striped Hyena In North Africa: Major Threats And Conservation Actions, Abderrazak El Alami, Abderrazzak Fattah, Ilyas El Alami, Ziad El Alami

Turkish Journal of Zoology

The striped hyena (Hyaena hyaena) is widely distributed across the northern half of Africa, the Middle East, the Arabian Peninsula, and parts of Asia. However,  numerous studies indicate that this carnivore is in decline, and it is currently classified  as near threatened on the IUCN Red List of threatened species. In North  Africa, the Hyaena hyaena barbara subspecies has been extirpated from many  areas. This article summarizes data collected from observations of the striped hyena  in North Africa between 2004 and 2024. Among the 418 striped hyenas recorded in  North Africa between 2004 and 2024, 18.4% (n = 77) were …

Sustainable Guiding Framework Of The Egyptian Rural Development Initiative (Hayah Karima), Eman Badawy Ahmed

Mansoura Engineering Journal

The Hayah Karima initiative launches to improve the standard of living for the most needy community groups across the Egyptian countryside, and it also contributes to improving the quality of services provided to the neediest villages. The research aims to propose a guiding framework for sustainability in villages of the Hayah Karima Initiative to achieve Egypt’s Sustainable Vision 2030. To achieve the goal, the research will study the goals, strategies, and principles of the Hayah Karima Initiative, the Egypt Vision 2030, COP 27, the sustainability evaluation criteria, and the Green Villages Initiative. Consequentially, in addition to A questionnaire to measure …

Culvert Retrofit With Green Filter Media For The Removal Of Phosphorus From Stormwater Runoff, Somdipta Bagchi, Zhiming Zhang, Olayinka Olayiwola, Bharadwaj Mandala, Rupali Datta, Subhasis Giri, Richard Lathrop, Dibyendu Sarkar

Michigan Tech Publications

Phosphorus is a ubiquitous contaminant in urban and agricultural landscapes. A retention basin located in the southern part of Barnegat Bay, New Jersey, was identified as receiving stormwater runoff with elevated phosphorus concentrations. The basin is surrounded by expanding urban development, contributing to the progressive degradation of water quality in the bay, which is already highly eutrophic. This study evaluated the effectiveness of a culvert retrofit with a green filter media composed of granulated-aluminum-based drinking water-treatment residuals (Al-WTR) and granular carbon (5:1 ratio, w/w) for the removal of phosphorus and suspended sediments from stormwater runoff. The performance of the filter …

Polθ Activity Modulates Sensitivity To Standard Therapies In Dnmt3a-Deficient Leukemia, Bac Viet Le, Umeshkumar Vekariya, Monika M. Toma, Margaret Nieborowska-Skorska, Marie-Christine Caron, Malgorzata Gozdecka, Zayd Haydar, Martin Walsh, Jayashri Ghosh, Elaine Vaughan-Williams, Paulina Podszywalow-Bartnicka, Anna-Mariya Kukuyan, Sylwia Ziolkowska, Jessica Atkins, Emir Hadzijusufovic, Gurushankar Chandramouly, Reza Nejati, Katarzyna Piwocka, Richard T. Pomerantz, George S. Vassiliou, Brian J.P. Huntly, Peter Valent, Mariusz Wasik, Alfonso Bellacosa, Jean-Yves Masson, Gaorav P. Gupta, Grant A. Challen, Tomasz Skorski

Department of Biochemistry and Molecular Biology Faculty Papers

Myeloid malignancies carrying somatic DNMT3A mutations (DNMT3Amut) are refractory to standard therapy. DNMT3Amut leukemia cells accumulate toxic DNA double-strand breaks (DSBs) and stalled replication forks, rendering them dependent on DNA damage response (DDR). We report here that DNA polymerase theta (Polθ), a key element in DSB repair by end-joining (Polθ-mediated end-joining [TMEJ]) and in fork restarting, promotes survival and proliferation of DNMT3Amut leukemia cells. Polθ is overexpressed in DNMT3Amut leukemia cells due to abrogation of PARP1 PARylation-dependent UBE2O E3 ligase-mediated ubiquitination and proteasomal degradation of Polθ. In addition, PARP1-mediated recruitment of the SMARCAD1-MSH2/MSH3 repressive complex to DSBs is diminished in …