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Articles 1291 - 1320 of 114005
Full-Text Articles in Entire DC Network
Bird Population Response To Abiotic And Biotic Stresses In Urban & Restored Oak Savannah Habitat, Annabelle Ball
Bird Population Response To Abiotic And Biotic Stresses In Urban & Restored Oak Savannah Habitat, Annabelle Ball
Posters - 2026
Birds are heavily impacted by urban development. Many experience habitat fragmentation and removal of food sources. However, other species can adapt to and even thrive in urban environments, thanks to certain tree species, bird feeders, and buildings. In North America, the house sparrow and the European starling are invasive species that benefit from urban environments (Bartelt, 2011; Fitzwater, 2014). Meanwhile, many habitats across the continent are experiencing restoration/rewilding efforts for the benefit of birds. One such habitat is the oak-savannah, which is characterized by 10-30% canopy cover and a mixture of prairie & woodland vegetation, supporting a high diversity of …
The Effects Human Presence Has On Dolphins Within A Natural Lagoon Enclosure In Managed Care, Mario Martinez, Winter Saldaña
The Effects Human Presence Has On Dolphins Within A Natural Lagoon Enclosure In Managed Care, Mario Martinez, Winter Saldaña
Posters - 2026
● Previous research looked into the overall behavior of dolphins in managed care using observations of location (Dudzinski & Hill, 2025).
● This study provides opportunities to investigate the effects of human presence on dolphin activity and space use (Lauderdale et al., 2022; Trone et al., 2005).
● Purpose - To determine if human presence affects dolphin behavior / spatial use of natural lagoon.
● H1: Dolphin clustering will be seen in the most Northern part of the lagoon and area associated with humans consistently (Melillo et al., 2009).
● H2: Higher activity levels will be observed during the “during” …
Exploratory Evaluation Of Handler Performance And Processing-Related Outcomes During Cattle Handling, Morgan Marquardt
Exploratory Evaluation Of Handler Performance And Processing-Related Outcomes During Cattle Handling, Morgan Marquardt
Department of Animal Science: Dissertations, Theses, and Student Research
Animals have several critical roles in society, including the production of food and fiber, and companionship. Contact with animals has been shown to benefit human physical and mental health, yet little research has investigated the impact that humans have on animals. Handler skill may considerably affect the extent to which humans influence animal health and wellbeing, and this may be a critical consideration for animal agriculture. Objective assessment of cattle handler skill has received limited attention in the scientific literature, despite its importance to human safety and animal welfare. When compared to less skilled handlers, highly skilled cattle handlers may …
Fisheries Research Report No. 358 - Recreational Fishing For Blue Swimmer Crab In Cockburn Sound: Estimates Of Effort And Catch In 2024/25, Alissa C. Tate, Claire B. Smallwood, Eva K M Lai
Fisheries Research Report No. 358 - Recreational Fishing For Blue Swimmer Crab In Cockburn Sound: Estimates Of Effort And Catch In 2024/25, Alissa C. Tate, Claire B. Smallwood, Eva K M Lai
Fisheries Research Reports
The Cockburn Sound Blue Swimmer Crab (Portunus armatus) fishery was reopened to recreational fishing in December 2024 following a 10-year closure. Monitoring was essential to assess fishing effort and catch for this species.
A boat ramp (bus route) survey at four key access points (Leeuwin, Woodman Point, Palm Beach, and Point Peron) and shore-based roving creel survey (Fremantle South Mole to Point Peron) were used to collect data from December 2024 to May 2025. These surveys provide estimates of fishing effort, total catch (kept and released), harvest and catch rates for Blue Swimmer Crab in Cockburn Sound.
A total of …
Characterization Of A Core Fungal Community And Captivity-Induced Gut “Mycobiome” Change In Fowler's Toad (Anaxyrus Fowleri), Alexander J. Bradshaw, Sinlan Poo, Tracey E. Malter, Rylie M. Strasbaugh, Brianna Bodner, Madison R. Hincher, Anne Devan-Song, Javier F. Tabima
Characterization Of A Core Fungal Community And Captivity-Induced Gut “Mycobiome” Change In Fowler's Toad (Anaxyrus Fowleri), Alexander J. Bradshaw, Sinlan Poo, Tracey E. Malter, Rylie M. Strasbaugh, Brianna Bodner, Madison R. Hincher, Anne Devan-Song, Javier F. Tabima
Biology
Amphibious animals, such as frogs, are found at the intersection of aquatic and terrestrial ecosystems. They may serve as keystone and sentinel species and play key roles in nutrient cycling and food webs. In recent decades, amphibians have experienced drastic population declines due to habitat loss, climate change, and disease. These declines have prompted investments in ex situ conservation and captive breeding programs, which aim to reduce extinction risk by creating assurance colonies and reintroducing individuals once threats are mitigated. A critical component of these programs is proper husbandry, which ensures the health and longevity of captive populations and their …
Epigenetic Mechanisms For Mediating The Transmission Of Prenatal Maternal Stress And Associated Neurodevelopmental Outcomes, Kaylee Vis
Senior Honors Theses
The hypothalamic-pituitary-adrenal (HPA) axis is the primary stress response system responsible for regulating cortisol release. During pregnancy, maternal stress can dysregulate the HPA axis, leading to elevated cortisol and corticosterone levels that impact fetal development. Excessive prenatal exposure to stress has been associated with alterations in fetal brain structure and function, increasing the risk for neurodevelopmental disorders such as autism spectrum disorder, attention-deficit/hyperactivity disorder, and anxiety. Emerging research supports the idea that these neurodevelopmental effects may be transmitted through epigenetic mechanisms. However, a gap remains in the literature regarding the specific mechanism of interaction between environmental stressors, heritable epigenetic information, …
Factors Influencing Sex-Based Movement Patterns In The Banded Garden Spider, Argiope Trifasciata (Forskal, 1776), Brandon R. Marrone
Factors Influencing Sex-Based Movement Patterns In The Banded Garden Spider, Argiope Trifasciata (Forskal, 1776), Brandon R. Marrone
School of Biological Sciences: Dissertations, Theses, and Student Research
Movement is a fundamental ecological process shaping how individuals acquire mates, secure resources, and navigate heterogeneous landscapes. In species with extreme sexual size dimorphism (eSSD), such as the orb‑weaving spider Argiope trifasciata, males and females are predicted to experience different movement pressures driven by their reproductive roles. This thesis examines how individual traits and environmental conditions jointly influence movement across both sexes. Across two field seasons, we used intensive mark–recapture methods to quantify natural movement patterns of males and females within mapped prairie plots. The first chapter tested long‑standing predictions gravity hypothesis, which posits that smaller males benefit from …
Alabama Prairie Reconstruction: Comparing Management Pathways For A Southeastern Landscape, Cecelia R. Geyer
Alabama Prairie Reconstruction: Comparing Management Pathways For A Southeastern Landscape, Cecelia R. Geyer
Theses
Southeastern prairies are highly biodiverse yet increasingly threatened by land-use change, fire suppression, and habitat fragmentation. These disturbance-dependent systems rely on periodic fire and grazing to maintain plant diversity and ecosystem function. This study evaluates prairie restoration strategies by testing predictions from the Intermediate Disturbance Hypothesis and the Patch Mosaic Burn Hypothesis. The study site was divided into three treatments: prescribed burned only (B), prescribed burned with mowing (BM) to simulate grazing, and an undisturbed control (C). A standardized mix of native plant seeds was broadcast across all treatments. Ecosystem health and function were evaluated using plant community diversity and …
Perceived Barriers To Integrated Crop–Livestock Systems: Evidence From A Nebraska Producer Survey, Omid Tarashtwal
Perceived Barriers To Integrated Crop–Livestock Systems: Evidence From A Nebraska Producer Survey, Omid Tarashtwal
Department of Agricultural Economics: Dissertations, Theses, and Student Research
Integrated crop-livestock systems offer agronomic, economic, and environmental benefits, yet reintegration has been slow across the Northern Great Plains despite sustained interest. Existing research has documented barriers to transition conceptually, but quantitative evidence on which barriers producers perceive as most important and which producer and operation characteristics are associated with stronger barrier perceptions remains limited. This thesis addresses that gap using data from the 2023 Nebraska Agriculture Operator Survey.
The analysis focuses on 241 Nebraska producers, including 179 crop-only and 62 livestock-only operations. Seven models are estimated, combining ordered logit estimation for single-item barriers with linear regression for averaged barrier …
Do Young Belugas Play More Or Less Than Adult Belugas?, Winter Saldana
Do Young Belugas Play More Or Less Than Adult Belugas?, Winter Saldana
Posters - 2026
★ The presence of play is used as an indicator of well-being in many species including belugas (Hill et al., 2017; Hill & Ramirez, 2014). ★ Adult and young belugas engage in similar types of play, but the frequency with which belugas play with objects, the actions used during those object play bouts, and the type of materials the objects consist of have not been examined in detail (Hill & Ramirez, 2014). ★ The purpose of this study was to explore if object play exhibited by belugas varied in frequency of play bouts, actions, and materials used by young and …
Role Of Listeria Adhesion Protein In Monocyte-Associated And Extracellular Translocation Of Listeria Monocytogenes Across The In Vitro Placental Barrier Co-Culture Model, Ayesha Atique
Biological Sciences Theses & Dissertations
Listeria monocytogenes is a facultative intracellular foodborne pathogen capable of crossing the placental barrier, leading to miscarriage, stillbirth, and neonatal sepsis, and has a fetal/neonatal fatality rate of ~20–30%. Although the importance of canonical virulence factors such as Internalin A (InlA) and Internalin B (InlB) in L. monocytogenes crossing of the placental barrier has been demonstrated, clinical strains lacking functional canonical internalins have been reported to cause severe neonatal disease, suggesting additional mechanisms of placental translocation.
To investigate these virulence mechanisms, we adapted a physiologically relevant co-culture human placental barrier Transwell model composed of BeWo trophoblasts and primary human placental …
Mechanisms Of Synergy Between Nanosecond Pulsed Electric Field (Nspef) And Cold Atmospheric Pressure Plasma Discharge (Cap) In Pancreatic Cancer: The Role Of Ros-Mediated Oxidative Stress And Apoptosis, Zobia Minhas
Theses and Dissertations in Biomedical Sciences
Pancreatic ductal adenocarcinoma is a highly lethal malignancy characterized by poor prognosis and resistance to conventional therapies. Novel treatment strategies are needed to overcome this resistance. Non-thermal physical modalities, including nanosecond pulsed electric field (nsPEF) and cold atmospheric pressure plasma discharge (CAP), have emerged as potential anticancer approaches; however, the mechanisms underlying their combined effects remain unclear.
This study evaluated whether nsPEF enhances CAP-induced cytotoxicity and investigated the associated molecular mechanisms using the murine Pan02 pancreatic cancer cell line. Cell viability was assessed by WST-1 metabolic activity assays and electric cell–substrate impedance sensing (ECIS). Intracellular reactive oxygen species (ROS) were …
Optimizing Duckweeds Harvesting Strategies To Maximize Nutrient Recovery And Its Role As A Phytosensor In Different Water Sources While Maintaining Sustainable Biomass Growth, Basma Ghannam
Theses
This thesis is concerned with determining the optimal water treatment and harvesting strategy for Lemna minor duckweed plants. The main objective of this thesis is to examine how duckweed plants grow in terms of biomass, photosynthetic activity, leaf morphology, chlorophyll and carotenoid content, and their efficiency in nutrient removal from different water sources. The methodology of the study included assessing duckweed in three water samples including tap water, saline water, and greywater and three harvesting strategies, including low, medium, and high harvesting intensities to assess their growth and nutrient removal efficiency. The results of the study showed that L. minor …
Comparative Efficacy Of Oral And Cloacal Administration Of Lactobacillus Probiotics And Postbiotics Against Campylobacter Jejuni Colonization In Broiler Chickens, Shreeya Sharma, Hosni Hassan, Khaled Abdelaziz
Comparative Efficacy Of Oral And Cloacal Administration Of Lactobacillus Probiotics And Postbiotics Against Campylobacter Jejuni Colonization In Broiler Chickens, Shreeya Sharma, Hosni Hassan, Khaled Abdelaziz
Publications
Campylobacter jejuni remains a major cause of foodborne illness worldwide, with poultry serving as the primary reservoir. In the absence of commercial vaccines or effective feed additives, probiotics and their byproducts (postbiotics) represent a promising and sustainable approach to reducing Campylobacter colonization in poultry. This study compared the efficacy of oral and cloacal administration of probiotic lactobacilli and their postbiotics in reducing Campylobacter colonization and modulating the cecal microbiome in broiler chickens. Day-old chicks were assigned to seven treatment groups that received either probiotics (live cells of four poultry-derived Lactobacillus strains: L. reuteri P43, L. acidophilus P42, L. animalis P38, …
Biol 454: Developmental Biology (Syllabus), Travis Bailey Ph.D.
Biol 454: Developmental Biology (Syllabus), Travis Bailey Ph.D.
School of Arts & Sciences
This syllabus was developed by SUNY Geneseo Professor Travis Bailey in the spring 2026 semester.
Learning Outcomes-Students will:
- Understand the methods scientist use to explore the genetic, cellular, and tissue control of development.
- Compare and contrast developmental strategies of model organisms.
- Read primary literature critically and explain strengths and weaknesses.
- Test hypotheses with self-designed experimentation, measurement and data collection, evaluation of evidence, and employment of mathematical analysis.
- Relate discoveries from model animals to human conditions.
- Communicate findings orally and in writing.
- Integrate multiple bodies of knowledge with their personal experience by asking meaningful questions about real-world problems
- Apply skills, theories, …
Teeth That Tell Time: Elemental Analysis From Shark Teeth, Gisele-Elizabeth Perez, David Turner
Teeth That Tell Time: Elemental Analysis From Shark Teeth, Gisele-Elizabeth Perez, David Turner
Research Papers
Sharks (Chondrichthyes) have hunted in the oceans for over 400 million years, their teeth leaving history behind, constantly becoming a part of the fossilization process (Worm et al. 2013). Their survival throughout 5 major extinctions is due to their ability to adapt easily with slow metabolism, a wide range of diet, and an efficient physiology. Shark teeth are vital to the hunting and consumption of their prey, making it a point for scientists to study them. Their tooth minerals contain fluorapatite in their enameloid, and dentin in the “root” of the tooth, with extinct species containing dentin and hydroxyapatite in …
Teeth That Tell Time: Elemental Analysis From Shark Teeth, Gisele-Elizabeth Perez
Teeth That Tell Time: Elemental Analysis From Shark Teeth, Gisele-Elizabeth Perez
Posters - 2026
Sharks (Chondrichthyes) have hunted in the oceans for over 400 million years, their teeth leaving history behind, constantly becoming a part of the fossilization process (Worm et al. 2013). Their survival throughout 5 major extinctions is due to their ability to adapt easily with slow metabolism, a wide range of diet, and an efficient physiology. Shark teeth are vital to the hunting and consumption of their prey, making it a point for scientists to study them. Their tooth minerals contain fluorapatite in their enameloid, and dentin in the “root” of the tooth, with extinct species containing dentin and hydroxyapatite in …
Mapping Sensory Landscapes: Distribution And Arrangement Of The Anterior Lateral Line System In Texas Catfish, Tatiana Flores, Ruben Tovar
Mapping Sensory Landscapes: Distribution And Arrangement Of The Anterior Lateral Line System In Texas Catfish, Tatiana Flores, Ruben Tovar
Research Papers
Fish have a system of sensory organs known as the lateral line system. This system contains numerous mechanoreceptive neuromasts and electroreceptive ampullary organs (Northcutt et al, 2000). Neuromasts are small, hair-like structures located within canals in the lateral line system just under the fish’s skin and are open to the environment through small pores visible on its skin (Parker, 2025). Water flows into these canals through the pores which stimulates the sensitive hair cells, resulting in electrical signals sent to the fish’s brain. The brain interprets these signals and creates “images” of the fish’s surroundings, helping it to see even …
Ecological Studies Of Wolves On Isle Royale, Sarah R. Hoy, Rolf O. Peterson, John A. Vucetich
Ecological Studies Of Wolves On Isle Royale, Sarah R. Hoy, Rolf O. Peterson, John A. Vucetich
Ecological Studies of Wolves on Isle Royale
Annual Report 2025-2026
Gamma Sigma Delta, Nebraska Chapter Newsletter, Issue #69 Spring 2026
Gamma Sigma Delta, Nebraska Chapter Newsletter, Issue #69 Spring 2026
Gamma Sigma Delta, Nebraska Chapter: Newsletters
President's message, Dustin Loy
Undergraduate Scholarship Awards
2026 Chapter Officers and Committees
Faculty Awards
Membership info and dues form
Grad Student Scholarship
Award of Merit
NU Foundation Fund
New Initiates
Save the Date
In Memoriam:
Kara Daye Heideman (March 31, 1980-December 11, 2025)
L. Dale Van Vleck (June 11, 1933-December 23, 2025)
James (Jim) Eugene Specht (September 12, 1945-February 13, 2026)
Irvin Thomas Omtvedt (June 12, 1935-April 6, 2026)
Fayrene L. Hamouz (June 6, 1946-April 8, 2026)
Robert L. Raun (April 22, 1928-April 22, 2026)
Mitochondria Dynamics In Microglia During Health, Inflammation, And Aging, Alicia Nicole Pietramale
Mitochondria Dynamics In Microglia During Health, Inflammation, And Aging, Alicia Nicole Pietramale
Dartmouth College Ph.D Dissertations
Microglia continually surveil the brain, allowing for rapid detection of tissue damage or infection. Microglial metabolism is linked to tissue homeostasis, yet how mitochondria are subcellularly partitioned in microglia and dynamically reorganize during surveillance, injury responses, and phagocytic engulfment in the intact brain has remained unclear. In this dissertation, I combine intravital imaging, ultrastructural analyses, and metabolic and cytoskeletal markers to investigate how mitochondrial organization relates to microglial function across health, inflammation, and aging.
I first show that microglial processes diverge in their mitochondrial content, with some containing multiple mitochondria while others are completely void. This heterogeneous partitioning is conserved …
Evaluation Of Tick-Derived Peptides For Transmission-Blocking Vaccine Candidates, Madelyn Futral
Evaluation Of Tick-Derived Peptides For Transmission-Blocking Vaccine Candidates, Madelyn Futral
Honors Theses
The lack of effective preventive measures for tick-borne diseases represents a major public health challenge. Transmission-blocking vaccines targeting tick molecules essential for feeding or reproduction could provide a sustainable and broad-spectrum solution. In this study, we evaluated two tick-derived proteins as potential vaccine antigens, subolesin, a key regulator of blood-feeding and cellular processes, and vitellogenin, a protein involved in egg development. Using bioinformatic tools, we identified immunogenic peptide sequences from each protein and chemically conjugated them to virus-like particles (VLPs) to enhance antigen presentation. C57BL/6 mice were immunized intradermally with VLP-peptide conjugates, followed by a booster dose. Blood and spleen …
Comparing Head Shape Of Polymorphic Subterranean E. Latitans And Subterranean E. Sp. 4, Brandon Chapa, Jordan Cosgrove, Lizzeth Holguin
Comparing Head Shape Of Polymorphic Subterranean E. Latitans And Subterranean E. Sp. 4, Brandon Chapa, Jordan Cosgrove, Lizzeth Holguin
Posters - 2026
Eurycea latitans (E. latitans) from Honey Creek Cave and unnamed Eurycea species from New Braunfels, Texas (E. sp. 4) are two paedomorphic subterranean species. E. latitans is polymorphic, meaning it also exists as a surface species. Similarities in morphology of subterranean salamander species may be due to convergent evolution as a result of living in similar environments. These similarities include having flatter, wider heads, and wider mouths than surface species (Tovar et al. 2025). Variation may also exist among different subterranean salamander species. Texas Eurycea salamanders display “complex patterns of morphological divergence”, suggesting that isolation and local environmental pressures can …
The Missing Lynx: Ivestigating Passive And Active Rewilding With The Eurasian Lynx, Isaiah Charles, Tatiana Flores, Isabella Lopez
The Missing Lynx: Ivestigating Passive And Active Rewilding With The Eurasian Lynx, Isaiah Charles, Tatiana Flores, Isabella Lopez
Posters - 2026
The Eurasian Lynx (Lynx lynx) is a wild cat native to the boreal forests, mountains and grasslands of Europe and Asia (Bhattacharyya, 2025). The Eurasian lynx keep ungulate populations in check which allow for forests to recover from overgrazing, promoting biodiversity and ecological balance. However, the Eurasian lynx had become locally extinct across Europe by the 1900s due to habitat loss, hunting by farmers in retaliation for predation of livestock and the illegal fur trade. Conservation and ecological restoration efforts to rebuild the lynx population have been underway. Rewilding is a form of ecological restoration involving the reintroduction of a …
Comparing Gngt1 Expression In Eye Tissue Of Polymorphic Salamander Species Through Development, Fiona Coulbourne, Camila Cardozo, Macarena Machado, Ruben Tovar
Comparing Gngt1 Expression In Eye Tissue Of Polymorphic Salamander Species Through Development, Fiona Coulbourne, Camila Cardozo, Macarena Machado, Ruben Tovar
Posters - 2026
The effect of the environment on organisms and their adaptations is widely studied. When exposed to different environmental niches, phenotypic adaptation is observed even within species. Animals that live in dark cave environments show a loss of their eyesight, since this sense is no longer useful to keep. Previous research has studied salamanders of the clade Eurycea and compared gene expression to subterranean and surface phenotypes1. E.pterophila is observed to express these two phenotypes depending on its environment, either Preserve Cave (subterranean) or Comal Springs (surface). Subterranean variant shows reduced eye volume and assumes to have decreased eyesight. Utilizing RNASeq …
Beluga Buddies: The Preferred Social Network Of Belugas In Managed Care, Valery Marinelarena, Diamond Garcia
Beluga Buddies: The Preferred Social Network Of Belugas In Managed Care, Valery Marinelarena, Diamond Garcia
Posters - 2026
Belugas societies are not fixed and group composition is everchanging. Group composition can also influence behavior. This study aims to examine the preferred social networks and the role age plays in the behavioral diversity within a group of managed care belugas housed at Sea World San Antonio. Results Supported TYO had a preferred, non-random social network and ATL performing more chinslaps than TYO.
Assessing Differential Expression In Skin Of Surface Versus Subterranean Salamanders (Eurycea) Through Development, Chiara Angelyn Maldonado, Van Nguyen, Amy Torres
Assessing Differential Expression In Skin Of Surface Versus Subterranean Salamanders (Eurycea) Through Development, Chiara Angelyn Maldonado, Van Nguyen, Amy Torres
Posters - 2026
In salamanders, previous findings have shown that subterranean environments impose different selection pressures on sensory systems than surface environments do (1). Differences in ocular development between phenotypes is part of ongoing research to better understand the evolutionary and molecular underpinnings. Studies have shown that parallel ocular development occurred in subterranean and surface phenotypes, while pax6 expression decreased in latter stages of development of subterranean species (2). These insights of gene labeling and expression as well as reduction of ocular structures in latter stages of development provide a stage for understanding evolutionary processes and genetic mechanisms as well as having potential …
Emerald Bowfin Amia Ocellicauda Ecology In Three Minnesota Lakes: Abundance, Age Analysis, Diet Composition, And Stable Isotope Food Web, Griffin Blegen
Emerald Bowfin Amia Ocellicauda Ecology In Three Minnesota Lakes: Abundance, Age Analysis, Diet Composition, And Stable Isotope Food Web, Griffin Blegen
Biology Graduate Theses
The Emerald Bowfin Amia ocellicauda is a predatory fish species native to Minnesota that has often been discriminated against. This research expands ecological knowledge of Bowfin in Minnesota and provides population data to guide future management. Bowfin were sampled in the spring of 2024 and 2025 and a multi-census mark–recapture model was used to estimate abundance in three lakes. Estimated populations were 196 individuals in Little Toad Lake (95% CI: 116, 242) or 4.4 fish/littoral ha (95% CI: 2.7,5.7), 657 in Lake Sarah (95% CI: 436, 1014) or 4.2 fish/littoral ha (95% CI: 3.0, 6.7), and 612 in Gun Lake …
Multiparametric Mri To Predict Response To Irreversible Electroporation Plus Anti-Pd-1 Immunotherapy In Pancreatic Ductal Adenocarcinoma, Qizhen Cao, Mark D Pagel, Charles V Kingsley, Jingfei Ma, James P Long, Xiaoxia Wen, Seth T Gammon, Jorge Delacerda, Sanaz Javadi, Chun Li
Multiparametric Mri To Predict Response To Irreversible Electroporation Plus Anti-Pd-1 Immunotherapy In Pancreatic Ductal Adenocarcinoma, Qizhen Cao, Mark D Pagel, Charles V Kingsley, Jingfei Ma, James P Long, Xiaoxia Wen, Seth T Gammon, Jorge Delacerda, Sanaz Javadi, Chun Li
Faculty, Staff and Student Publications
Purpose: To investigate contrast-enhanced T1-weighted MRI and diffusion-weighted magnetic resonance imaging (DWI) for early prediction of tumor response to combined irreversible electroporation (IRE) and anti-PD-1 immunotherapy.
Methods: Murine pancreatic ductal adenocarcinoma (PDAC) cells KRAS* were inoculated into the pancreas of C57BL/6 mice. IRE was performed when tumors became palpable. After IRE, mice received six intraperitoneal injections of anti-PD-1 over 2 weeks. T2-weighted MRI, T1-weighted MRI with macromolecular contrast agent poly(L-glutamic acid)-conjugated gadolinium (PG-Gd), and DWI were performed before and after IRE. Survival was analyzed using Kaplan-Meier curves. Mice surviving at least 100 days without recurrence after IRE were considered complete …
Neutrophil-Microglia Interaction Drives Motor Dysfunction In A Neuromyelitis Optica Model Induced By Subarachnoid Aqp4-Igg, Fangfang Qi, Vanda A Lennon, Shunyi Zhao, Yong Guo, Husheng Ding, Caiyun Liu, Whitney M Bartley, Tingjun Chen, Claudia F Lucchinetti, Long-Jun Wu
Neutrophil-Microglia Interaction Drives Motor Dysfunction In A Neuromyelitis Optica Model Induced By Subarachnoid Aqp4-Igg, Fangfang Qi, Vanda A Lennon, Shunyi Zhao, Yong Guo, Husheng Ding, Caiyun Liu, Whitney M Bartley, Tingjun Chen, Claudia F Lucchinetti, Long-Jun Wu
Faculty, Staff and Student Publications
Neutrophils and neutrophil extracellular traps (NETs) contribute to early neuromyelitis optica (NMO) histopathology initiated by IgG targeting astrocytic aquaporin-4 (AQP4) water channels. Yet, the mechanisms underlying neutrophil recruitment and their pathogenic roles in disease progression remain unclear. To investigate molecular-cellular events preceding classical complement cascade activation in a mouse NMO model, we continuously infused, via spinal subarachnoid route, a non-complement-activating mouse monoclonal AQP4-IgG. Parenchymal infiltration of netting neutrophils containing C5a ensued with microglial activation and motor impairment but no blood-brain barrier leakage. Motor impairment and neuronal dysfunction both reversed when AQP4-IgG infusion stopped. Two-photon microscopy and electron microscopy-based reconstructions revealed …