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Determination Of The Effects Of Different Maillard Reaction Products On The Taxonomic Composition Of The Gut Microbiota, Nesreen Hamdan Aljahdali Dec 2017

Determination Of The Effects Of Different Maillard Reaction Products On The Taxonomic Composition Of The Gut Microbiota, Nesreen Hamdan Aljahdali

Graduate Theses and Dissertations

The Maillard Reaction (MR) is a non-enzymatic chemical reaction which results in linkage between the amino group of amino acids and the carbonyl group of reduced sugars. This reaction generates Maillard reaction products (MRPs) which are not present naturally in foods, and are responsible for a range of colors, odors, flavors, and other sensory properties. Conflicting reports of MRPs impacts on human health are probably due to the fact that bioconversion of these digestible molecules by the gut microbiota has been marginally taken into account. This study aimed to determine the effects of different MRPs on rodent’s gut microbiota through16S …


The Effect Of Preflood Nitrogen And Flood Establishment Timing On Rice Development, Nitrogen Uptake And Grain Yield, Tyler Richmond Dec 2017

The Effect Of Preflood Nitrogen And Flood Establishment Timing On Rice Development, Nitrogen Uptake And Grain Yield, Tyler Richmond

Graduate Theses and Dissertations

Urea-N fertilizer is typically applied at the 5-leaf stage to rice (Oryza sativa L.) grown in a dry-seeded, delayed-flood production system. How long the preflood-N can be delayed without adverse effects on yield potential is poorly understood. The research objective was to determine the effects of preflood-N application and flood establishment timing on aboveground-N content, 50% heading, yield components, and grain yield. Trials were established on silt loam soils at the Pine Tree Research Station (PTRS) and Rice Research and Extension Center (RREC) during 2015 and 2016. Urea-N was applied at 0, 45, 90, 135, and 180 kg N ha-1 …


Evaluation Of Very-Long-Chain Fatty Acid-Inhibiting Herbicides In Arkansas Rice Production, John Ansley Godwin Dec 2017

Evaluation Of Very-Long-Chain Fatty Acid-Inhibiting Herbicides In Arkansas Rice Production, John Ansley Godwin

Graduate Theses and Dissertations

Because of the evolution of herbicide-resistant weeds, such as barnyardgrass and red rice in rice, there is a need for alternative herbicide sites of action. Very-long-chain fatty acid (VLCFA)-inhibiting herbicides are not labeled for use in U.S. rice production; however, this site of action (SOA) has been used with success in Asian rice. The VLCFA-inhibiting herbicides pethoxamid, pyroxasulfone, acetochlor, and S-metolachlor were evaluated for rice tolerance and control of commonly problematic weeds in Arkansas rice at various rates and application timings. Pyroxasulfone and S-metolachlor were deemed unfit for use in rice production because of negative effects on rice visual injury, …


Evaluation Of Insecticide Seed Treatments To Protect Rice (Oryza Sativa) Against Various Herbicides, Steven Michael Martin Dec 2017

Evaluation Of Insecticide Seed Treatments To Protect Rice (Oryza Sativa) Against Various Herbicides, Steven Michael Martin

Graduate Theses and Dissertations

The increase in herbicide-resistant weeds in Arkansas crop fields has led to the need for new herbicide modes of action for use in all crops. This need has led to the introduction of technologies that can be devastating to conventional rice crops. Field observation, noted that insecticide seed treatments used in rice could potentially reduce the effects of off-target movement of herbicides onto rice crops and possibly reduce the negative effects of some herbicides applied directly to rice. Research was conducted to determine if insecticide seed treatments could reduce the harmful effects of drift from imazethapyr and glyphosate onto conventional …


In The Field The Women Saved The Crop: The Women’S Land Army Of World War Ii, Denna M. Clymer Dec 2017

In The Field The Women Saved The Crop: The Women’S Land Army Of World War Ii, Denna M. Clymer

Graduate Theses and Dissertations

The Women’s Land Army brought together rural and urban sectors of the United States in a climate of national and regional crisis. By the time the country was cast into war, the agricultural sector was already caught in a downward economic spiral that drove away laborers. With demand falling, and farms propped up only by experiments in subsidy and parity, when military and industrial jobs emerged in urban areas, farm laborers became scarce. At the same time the war created jobs for men outside of the agricultural sector, farm prices recovered and demand soared, forcing farmers to look to women …


Cellular Mechanisms Of Ionoregulation In The Gill Of Japanese Medaka And Rainbow Trout, Rebecca Jo Bollinger Dec 2017

Cellular Mechanisms Of Ionoregulation In The Gill Of Japanese Medaka And Rainbow Trout, Rebecca Jo Bollinger

Graduate Theses and Dissertations

Euryhaline fishes are capable of adapting to a wide range of salinities such as freshwater, brackish water or seawater. Through the combined effort of the gill, kidney and intestine, they are able to osmoregulate to maintain a constant internal hydromineral balance. As the gill is in direct contact with the external environment, it is continuously working to maintain ion and acid/base balance, gas exchange and eliminate nitrogenous waste. Fish in freshwater are subjected to osmotic water gain and diffusional ion loss across the gill and experience the opposite in seawater. Therefore, the gill exhibits extreme plasticity when experiencing a change …


Evaluation Of The Impact Of Tart Cherries Polyphenols On The Human Gut Microbiota And Phenolic Metabolites In Vitro And In Vivo, Alba Claudia Mayta-Apaza Dec 2017

Evaluation Of The Impact Of Tart Cherries Polyphenols On The Human Gut Microbiota And Phenolic Metabolites In Vitro And In Vivo, Alba Claudia Mayta-Apaza

Graduate Theses and Dissertations

Tart cherries are polyphenol abundant stone fruits claimed to exert health benefits further of its nutritional properties. The abundant phytochemicals content in tart cherries also referred as dietary polyphenols have been considered as an effective natural antioxidant when added in daily diet. However, it has been hypothesized the intervention of gut microbiota on the overall functionality of such compounds. This thesis contains a wide-ranging literature review focused on tart cherry as a crop, current market, functional food, and several health benefits. Furthermore, the research done describes and in vitro and in vivo assays of a short-term dietary intervention of tart …


Evaluation Of Provisia Rice In Arkansas Rice Production Systems, Zachary Lancaster Dec 2017

Evaluation Of Provisia Rice In Arkansas Rice Production Systems, Zachary Lancaster

Graduate Theses and Dissertations

With the continued evolution of herbicide resistance, it is becoming more difficult to achieve adequate weed control in Arkansas rice production systems. Thus, new technologies are needed to combat these troublesome weeds. A new non-GMO, herbicide-resistant rice type is under development that is resistant to quizalofop, an acetyl coenzyme A carboxylase (ACCase)-inhibiting herbicide that will allow for selective grass weed control in rice. With the commercialization of this technology by 2018, research was conducted to determine the best fit for quizalofop-resistant rice in current production systems. Experiments included evaluation of off-target movement of quizalofop, determination of plant-back risk from quizalofop …


Detection Of Survival And Proliferation Of Sulfate Reducers Under Simulated Martian Atmospheric And Soil Conditions, Sergio Mosquera Mora Dec 2017

Detection Of Survival And Proliferation Of Sulfate Reducers Under Simulated Martian Atmospheric And Soil Conditions, Sergio Mosquera Mora

Graduate Theses and Dissertations

Numerous studies have tried to determine the survivability and proliferation of microorganisms under simulated Martian conditions. Furthermore, most of them have been focused on the ability of these microbes to cope with high brines’ salt (NaCl) concentrations inherent of the Martian surface. However, there are not studies related to the ability of bacteria to survive on subsurface environments that have increasing concentrations of sulfate compounds. For this research, a group of microorganisms known as sulfate-reducing bacteria or simply sulfate reducers were chosen due to their ability to use sulfate compounds as terminal electron acceptors to produce metabolic energy, their tolerance …


Fall Risk In Sedentary, Recreationally Active, And Masters Athlete Older Adults, Felicia Elizabeth Squires Dec 2017

Fall Risk In Sedentary, Recreationally Active, And Masters Athlete Older Adults, Felicia Elizabeth Squires

Graduate Theses and Dissertations

The purpose of this study was to examine whether different habitual activity levels may affect balance ability in older adults. Balance must be studied as poor balance increases likelihood of falls. This study examined activity levels in older adults and effect on balance ability. Fifty-nine older adults aged 66.5 ± 9.5 participated. Three groups were separated by physical activity level. First group had 13 masters athletes, older adults performing least 150 minutes of aerobic activity a week and competing in nationally sanctioned event within the last six months. Twenty-seven older adults comprised recreationally active group performing at least 150 minutes …


Qualitative Analysis Of Social Capital In Arkansas – A Case Study Based Approach, Valerie Kilders Aug 2017

Qualitative Analysis Of Social Capital In Arkansas – A Case Study Based Approach, Valerie Kilders

Graduate Theses and Dissertations

Despite the vast research on social capital in general, only very little research is focused on the quality of social capital. While some research studies incorporated aspects that are associated with the quality of social capital, they often take a one dimensional approach that fails to take the different aspects of the topic into consideration. In order to gain more insights into this I conducted a series of semi-structured interviews in three rural counties in Arkansas. The counties were selected on the basis of a social capital index of all U.S. counties using quantitative measures. I used a guide on …


Effects Of Northern Bobwhite Management On Raccoon Abundance, Habitat Selection, And Home Range In Southwest Missouri, Jacob Cody Mcclain Aug 2017

Effects Of Northern Bobwhite Management On Raccoon Abundance, Habitat Selection, And Home Range In Southwest Missouri, Jacob Cody Mcclain

Graduate Theses and Dissertations

Habitat management has become vital for northern bobwhite (Colinus virginianus) conservation. In Missouri, efforts to conserve remaining populations on public lands have included the use of two management models. The Intensive Management Model (IMM) promotes hard edges, by creating a juxtaposition of different habitat types, while the Extensive Management Model (EMM) maintains a grassland-dominated landscape through the processes of fire and grazing. Preliminary results suggest that bobwhite success is significantly higher on EMM sites than IMM sites. Management efforts through IMM may be hindered by unintentionally managing for nest predators like raccoons (Procyon lotor). Nest predators may forage more often …


The Influence Of Visual Storytelling On The Occupational Aspirations Of Non-Agricultural Undergraduate Students, Hanan Marie Southard Aug 2017

The Influence Of Visual Storytelling On The Occupational Aspirations Of Non-Agricultural Undergraduate Students, Hanan Marie Southard

Graduate Theses and Dissertations

The agricultural industry has been experiencing a shortage in qualified college graduates to fill its numerous open positions in recent years. The purpose of this study was to investigate the influence of visual storytelling on the occupational aspirations of non-agricultural undergraduate students. Social media channels, virtual storytelling and the higher education classroom provide a unique opportunity to convey information about and recruit students into the agricultural career field. The diffusion of innovation model provides the framework for the introduction of agricultural jobs in a non-agricultural business classroom while the social cognitive theory provides the understanding of the importance of self-efficacy …


Removal Of Endocrine Disrupting Compounds Using Membrane Bioreactor, Mohanad Ali Abdulsahib Kamaz Aug 2017

Removal Of Endocrine Disrupting Compounds Using Membrane Bioreactor, Mohanad Ali Abdulsahib Kamaz

Graduate Theses and Dissertations

The presence of endocrine disrupting compounds (EDCs) and pharmaceutically active compounds (PhAC) such as pesticides, personal care products, antibiotics and pharmaceutical compounds, in sewage, industrial, and domestic waters has extensively become the major concern for health and environmental organizations. These compounds have the ability to interact with mammalian endocrine system and disrupting their functions. The traditional activated sludge processes are designed to degrade solids, organic carbon and nitrogen loading. Although several treatment steps in a wastewater treatment plant can contribute to partial removal of EDCs, effective removal has been a challenge due to their resistant chemical and biological degradation and …


A Comparative Analysis Of Feed And Environmental Factors On Broiler Growth In The United States, Alexandra Gulli Aug 2017

A Comparative Analysis Of Feed And Environmental Factors On Broiler Growth In The United States, Alexandra Gulli

Graduate Theses and Dissertations

Broiler production in the United States has become an important industry within the last half century. As the demand for poultry continues to increase and the concern of climate change also increases, it will become an important part of the industry to become more sustainable. This study uses a feed optimization model, a broiler growth model, and a life cycle assessment (LCA) to determine how feed ingredients and the barn environment can affect the broiler’s growth and production emissions. A multi-criteria ration optimization model is used to produce feeds based on carbon footprint and cost. A growth model is used …


Genomic And Physiological Approaches To Improve Drought Tolerance In Soybean, Avjinder Kaler Aug 2017

Genomic And Physiological Approaches To Improve Drought Tolerance In Soybean, Avjinder Kaler

Graduate Theses and Dissertations

Drought stress is a major global constraint for crop production, and improving crop tolerance to drought is of critical importance. Direct selection of drought tolerance among genotypes for yield is limited because of low heritability, polygenic control, epistasis effects, and genotype by environment interactions. Crop physiology can play a major role for improving drought tolerance through the identification of traits associated with drought tolerance that can be used as indirect selection criteria in a breeding program. Carbon isotope ratio (δ13C, associated with water use efficiency), oxygen isotope ratio (δ18O, associated with transpiration), canopy temperature (CT), canopy wilting, and canopy coverage …


Improvement In Simple Artificial Insemination In Sheep Using Chilled Extended Semen And Consideration Of Fertility In Ewes, Mohan Acharya Aug 2017

Improvement In Simple Artificial Insemination In Sheep Using Chilled Extended Semen And Consideration Of Fertility In Ewes, Mohan Acharya

Graduate Theses and Dissertations

Three studies were conducted to improve simple artificial insemination in sheep using chilled extended semen and evaluate methods to predict fertility in ewes. The first study evaluated the effect of semen extenders and storage temperature on motility parameters of ram semen stored for up to 72 h. Single semen collected from each ram was divided into four parts and extended using four extenders: milk, TRIS, TEST, and CJ-2, diluted to 600 million sperm/ml and loaded into 0.25 ml straws for storage at 4 and 15° C. Most of the CASA motility parameters were higher after extension and storage at 4 …


A Numerical Study Of The Interaction Between One Dimensional Carbyne Chain And Single Stranded Dna, Zeina Salman Aug 2017

A Numerical Study Of The Interaction Between One Dimensional Carbyne Chain And Single Stranded Dna, Zeina Salman

Graduate Theses and Dissertations

resolution at the single nucleotide level when developing DNA sequencers. The purpose of this research was to numerically study the electrical properties associated with the interaction between 1D carbon chain, known as carbyne, and ssDNA. First, the electrical properties of the carbyne chain were calculated. Second, the electrical properties of the carbyne chain were calculated in the presence of different ssDNA bases. Analyzing the differences between the two cases led to determining the effects of these different bases on the electrical properties. The numerical simulation approach conducted in this research was based on the first-principle simulation. The first-principle simulation was …


Membranes For Food And Bioproduct Processing, Alexandru Marius Avram Aug 2017

Membranes For Food And Bioproduct Processing, Alexandru Marius Avram

Graduate Theses and Dissertations

Modified membranes for process intensification in biomass hydrolysis

Production of biofuels and chemicals from lignocellulosic biomass is one of the leading candidates for replacement of petroleum based fuels and chemicals. However, conversion of lignocellulosic biomass into fuels and chemicals is not cost effective compared to the production of fuels and chemicals from crude oil reserves. Some novel and economically feasible approaches involve the use of ionic liquids as solvents or co-solvents, since these show improved solvation capability of cellulose over simple aqueous systems. Membranes offer unique opportunities for process intensification which involves fractionation of the resulting biomass hydrolysate leading to …


Studies In Blackberry: Development And Implementation Of A Phenotyping Protocol For Blackberry Seedling Populations And Impact Of Time Of Day Of Harvest On Red Drupelet Reversion For University Of Arkansas Blackberry Genotypes, Melinda Yin Aug 2017

Studies In Blackberry: Development And Implementation Of A Phenotyping Protocol For Blackberry Seedling Populations And Impact Of Time Of Day Of Harvest On Red Drupelet Reversion For University Of Arkansas Blackberry Genotypes, Melinda Yin

Graduate Theses and Dissertations

There are two major public blackberry (Rubus L. subgenus rubus Watson) breeding programs in the United States: one at the University of Arkansas (UA) and another at the U.S. Department of Agriculture Agricultural Research Service Horticultural Crops Research Unit (USDA-ARS HCRU) based in Corvallis, OR. The germplasm and breeding objectives of these two breeding programs are diverse, but frequent collaboration necessitated a standardized method of characterizing plant and fruit traits. A phenotyping protocol for blackberry was developed at UA and implemented for two years on UA seedling populations. The protocol included plant traits (health, vigor, estimated crop load, peak bloom …


Evaluation Of Screening Methods To Detect Heat Stress In Diverse Cotton Genotypes, Mathilda M. Van Der Westhuizen Aug 2017

Evaluation Of Screening Methods To Detect Heat Stress In Diverse Cotton Genotypes, Mathilda M. Van Der Westhuizen

Graduate Theses and Dissertations

Cotton (Gossypium hirsutum L.) is sensitive to heat stress (HS) during reproductive development. The objective of this study was to evaluate different screening methods for identification of heat tolerance in cotton genotypes. Three growth chamber studies and four field trials were conducted from 2014 to 2017 using genotypes Arkot 9704, VH260, DP 210 B2RF and DP393. Measurements were made of membrane leakage (ML), chlorophyll fluorescence (ChlF), glutathione reductase (GR), and sucrose concentration. In the growth chambers, measurements were made at 30 and 40°C and at 2, 4 and 6 hours of HS, as well as 3 and 7 days after …


Membrane Surface Engineering For Biochemical Applications, Anh T. Vu Aug 2017

Membrane Surface Engineering For Biochemical Applications, Anh T. Vu

Graduate Theses and Dissertations

Synthetic membranes have been frequently used for many fields, such as, the food and beverage, biopharmaceutical, and biofuel industries. In the beer industry, microfiltration frequently suffers from fouling due to the interaction between different species. It is shown that polyphenols can form cross-links with protein molecules, forming insoluble aggregates. However, by adding an optimal amount of polysaccharides these aggregates can be disrupted thus reducing fouling by the aggregates. Confocal laser scanning microscopy (CLSM) is a powerful technique to locate the foulants inside the wet membrane in order to understand more about the behavior of fouling in microfiltration.

Membrane surface modification …


Evaluating Thermal Comfort Of Broiler Chickens During Transportation Using Heat Index And Simulated Electronic Chickens, Kaushik Luthra Aug 2017

Evaluating Thermal Comfort Of Broiler Chickens During Transportation Using Heat Index And Simulated Electronic Chickens, Kaushik Luthra

Graduate Theses and Dissertations

Broilers experience high physiological stress during pre-slaughter transport, especially under extremes of thermal environment. Characterization of thermal environment on the trailer is crucial to identify stress-prone regions during transportation. At the same time, Broilers experience high physiological stress during pre-slaughter transport, especially under extremes of thermal environment. Characterization of thermal environment on the trailer is crucial to identify stress-prone regions during transportation. At the same time, quantification of heat loss of the broilers loaded on trailers is important in understanding the well-being of the broilers. We have developed four electronic chickens (E-chickens) to simulate the sensible heat loss of live …


Application Of X-Ray Imaging As A Technique For Fissure Detection In Rough Rice Kernels, Zephania R. Odek Aug 2017

Application Of X-Ray Imaging As A Technique For Fissure Detection In Rough Rice Kernels, Zephania R. Odek

Graduate Theses and Dissertations

Fissured rice kernels break during milling, leading to head rice yield (HRY) reductions. Conventional fissure detection instruments cannot be used to observe fissures in rough rice kernels, the form in which rice in normally dried and stored. X-rays can penetrate hulls allowing visualization of the internal structure of a rough rice kernel. This study evaluated the capability of X-ray imaging to adequately detect fissures in rough rice and established a correlation between HRY and the fissured kernel percentage (FKP) in a rough rice sample. Fifteen long-grain rice cultivars, harvested in Arkansas in 2015 and 2016 were dried using heated air …


Bee Communities On Managed Emergent Wetlands In The Lower Mississippi Alluvial Valley Of Arkansas, Phillip Lee Stephenson Aug 2017

Bee Communities On Managed Emergent Wetlands In The Lower Mississippi Alluvial Valley Of Arkansas, Phillip Lee Stephenson

Graduate Theses and Dissertations

Native bee communities that use emergent wetlands are among the least studied systems in bee research. Most native bee species are thought to be in decline based on the loss of usable habitat across the United States. I surveyed emergent wetlands in the lower Mississippi Alluvial Valley of Arkansas during the summers of 2015 and 2016 using pan traps, blue-vane traps, and sweep nets to determine the current status of bee communities in this system. I surveyed 11 sites in 2015 and 17 sites in 2016 and found that bee communities were similar in actively versus passively managed emergent wetlands. …


Linear Dna-Linked Nanoparticle Building Blocks (Nblocks) For Modular Self-Assembly Of Nanostructures, Jakob Thomas Hockman Aug 2017

Linear Dna-Linked Nanoparticle Building Blocks (Nblocks) For Modular Self-Assembly Of Nanostructures, Jakob Thomas Hockman

Graduate Theses and Dissertations

Controlling the shapes and sizes of nanomaterials often enables controlling their properties for certain applications. The most promising methods for controlling the shapes and sizes of nanostructures use base-pairing between complementary DNA strands to self-assemble nanostructures from DNA and nanoparticles. DNA Brick-based self-assembly is a particularly useful method for creating DNA nanostructures. It offers a large amount of control over the final shapes and sizes because it uses building blocks that are anisotropic and have predictable geometry. However, this control has not been extended to the self-assembly of nanostructures from nanoparticles. Applying DNA Brick based self-assembly to the self-assembly of …


Characterization Of The Relationships Between Soybean Yield, Trifoliolate Leaf Chloride Concentration, And Cultivar Chloride Inclusion/Exclusion Rating, Dillon Cox Aug 2017

Characterization Of The Relationships Between Soybean Yield, Trifoliolate Leaf Chloride Concentration, And Cultivar Chloride Inclusion/Exclusion Rating, Dillon Cox

Graduate Theses and Dissertations

Chloride toxicity is recognized as yield limiting problem in soybean [Glycine max (L.) Merr.] production. Limited information is available to accurately diagnose and manage Cl toxicity. The only recommendation for Cl toxicity management is to plant an excluder cultivar, however the cultivar Cl sensitivity rating system (excluder, includer, and mixed) does not appear to capture the variability in cultivar Cl tolerance. The objectives of this research were to i) develop critical tissue-Cl concentrations in which yield loss occurs for excluder and includer cultivars and ii) investigate the variability in cultivar Cl ratings. A study was conducted across five site-years using …


Effects Of Chemical And Enzymatic Modifications On Starch And Naringenin Complexation, Ana Isabel Gonzalez Conde Aug 2017

Effects Of Chemical And Enzymatic Modifications On Starch And Naringenin Complexation, Ana Isabel Gonzalez Conde

Graduate Theses and Dissertations

Naringenin is a flavanone naturally present in grapefruit and tomato skin, which has been demonstrated to have health benefits. However, because of the low water solubility and bioavailability, naringenin applications are limited. Starch inclusion complexes have been shown to improve the solubility and bioavailability of poorly water soluble bioactive compounds. The present study aimed to prepare and characterize complexes of naringenin with starches, including potato starch and high amylose corn starch (Hylon VII), which were chemically (acetylation or hydroxypropylation) and enzymatically modified (debranched or debrahced/β-amylase treated). Soluble and insoluble complexes were recovered, and their physicochemical properties were characterized. The treatments …


Experiment-Based Quantitative Modeling For The Antibacterial Activity Of Silver Nanoparticles, Mohammad Aminul Haque Aug 2017

Experiment-Based Quantitative Modeling For The Antibacterial Activity Of Silver Nanoparticles, Mohammad Aminul Haque

Graduate Theses and Dissertations

Silver (Ag) has been well known for its antimicrobial activity for a long time. Recent research showed the potential of Ag nanoparticles as emerging antimicrobial agents. However, little quantitative analysis has been performed so far to decipher the mechanism of interaction between nanoparticles and bacteria. Here, a detailed analysis based on kinetic growth assay and colony forming unit assay has been carried out to study the antimicrobial effect of Ag nanoparticles against Escherichia coli (E. coli) bacteria. It was observed that the presence of Ag nanoparticles increased the lag time of bacterial growth while not affecting the maximum growth rate …


Identifying Three-Way Gene Interactions From Microarray Data Using Kolmogorov-Smirnov And Cross-Match Tests, Shubhashree Khadka Aug 2017

Identifying Three-Way Gene Interactions From Microarray Data Using Kolmogorov-Smirnov And Cross-Match Tests, Shubhashree Khadka

Graduate Theses and Dissertations

Human gene network is much more complex than just pairwise interaction among the genes. Zhang et al. [6] extracted microarray data from International Genomics Consortium (IGC), and presented the detection of three-way gene interactions in their paper using Fisher’s z-transformation test. Three-way gene interactions are closer than pairwise correlations in representing the complex gene structures. Additionally, it was more tractable than assessing four or more gene interactions. In this paper, we are simulating different models where Fisher’s test might not be as effective. Zhang et al.’s approach utilized Pearson’s correlation coefficients and involved detection of linear interactions only. Since gene …