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Directional Selection Causes Decanalization In A Group I Ribozyme, Eric J. Hayden, Christian Weikert, Andreas Wagner
Directional Selection Causes Decanalization In A Group I Ribozyme, Eric J. Hayden, Christian Weikert, Andreas Wagner
Eric J. Hayden
A canalized genotype is robust to environmental or genetic perturbations. Canalization is expected to result from stabilizing selection on a well-adapted phenotype. Decanalization, the loss of robustness, might follow periods of directional selection toward a new optimum. The evolutionary forces causing decanalization are still unknown, in part because it is difficult to determine the fitness effects of mutations in populations of organisms with complex genotypes and phenotypes. Here, we report direct experimental measurements of robustness in a system with a simple genotype and phenotype, the catalytic activity of an RNA enzyme. We find that the robustness of a population of …