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Sheep Updates 2005 - Part 3, Rob Davidson, David Pethick, C. F. Engelke, B. D. Siebert, K. Gregg, A-D G. Wright, P. E. Vercoe, Robin Jacob, Russell Barnett, Joanne Sneddon, Sandra Brown, G. Rose, C. Kabore, J Dart, Stuart Adams Jul 2005

Sheep Updates 2005 - Part 3, Rob Davidson, David Pethick, C. F. Engelke, B. D. Siebert, K. Gregg, A-D G. Wright, P. E. Vercoe, Robin Jacob, Russell Barnett, Joanne Sneddon, Sandra Brown, G. Rose, C. Kabore, J Dart, Stuart Adams

Sheep Updates

This session covers seven papers from different authors: CUSTOMER 1. Benefits VIAscanR to producers and WAMMCO, Rob Davidson, Supply Development Manager, David Pethick, School of Veterinary and Biomedical Studies, Murdock University. 2. Healthy fats in lamb: how WA lambs compare with others, C. F. Engelke Animal Biology, University of Western Australia, bCSIRO Livestock Industries, Western Australia B.D. Siebert, Department of Animal Science, University of Adelaide, South Australia, K. Gregg, Centre for High-Throughput Agricultural Genetic Analysis, Murdoch University, Western Australia. A-D.G. Wright CSIRO Livestock Industries, Western Australia, P.E Vercoe Animal Biology, University of Western Australia 3. Shelf life of fresh lamb …


Effects Of Long-Term Storage On Quality Of Wheat Packaged In No. 10 Cans, R. Green, Devin J. Rose, Lynn V. Ogden, Oscar A. Pike Jul 2005

Effects Of Long-Term Storage On Quality Of Wheat Packaged In No. 10 Cans, R. Green, Devin J. Rose, Lynn V. Ogden, Oscar A. Pike

Faculty Publications

There is interest in the long-term storage of low-moisture foods for applications such as space flight, disaster relief, and personal preparedness. Wheat packaged in restaurant-size No. 10 cans has been available in the retail market for decades. However, the quality of such wheat held in long-term storage is not well characterized. The purpose of this research was to examine the effects of long-term storage on the quality of wheat packaged in No. 10 cans and held at ambient temperatures up to 32 years. Twenty samples of hard red wheat (including 4 duplicates) packaged in No. 10 cans were obtained from …


Effects Of Feeding Regular Eggs, N-3 Fatty Acid Enriched Eggs, And Walnuts, On Blood Lipids, Membrane Incorporation Of Fatty Acids, And Serum Lutein, In Free-Living Lacto-Ovo Vegetarians, Bonny Burns-Whitmore Jun 2005

Effects Of Feeding Regular Eggs, N-3 Fatty Acid Enriched Eggs, And Walnuts, On Blood Lipids, Membrane Incorporation Of Fatty Acids, And Serum Lutein, In Free-Living Lacto-Ovo Vegetarians, Bonny Burns-Whitmore

Loma Linda University Electronic Theses, Dissertations & Projects

Americans do not receive enough n-3 fatty acids (F. A.) in their diets. Walnuts are good source of α-linolenic acid (ALA), while n-3 F.A. enriched eggs provide a dietary source of DHA. Whether ALA and DHA have equivalent effects modifying cardiovascular risk factors is not known. This study compared the changes in blood and erythrocyte membrane lipids in twenty free-living lacto-ovo vegetarians following the consumption of regular eggs (6/wk), n-3 F.A. enriched eggs (6/wk), or walnuts (6 oz/wk) in a triple crossover design.

Results indicate significant differences between treatments for serum triacylglycerols (TAGs), total cholesterol (TC), apo B, apo B: …


International Students’ Perceptions Of Food Service At A New Jersey State University, Rebecca Ann Schubert May 2005

International Students’ Perceptions Of Food Service At A New Jersey State University, Rebecca Ann Schubert

Theses, Dissertations and Culminating Projects

The aim of this study is to explore international students’ perceptions of food service at Montclair State University. Twelve international students were recruited to participate in this quick ethnography. Seven of the twelve participants were males and five were females. Students came from a variety of ethnic backgrounds including Asian/Pacific Islander, African, Hispanic and White, non-Hispanic. Inclusion criteria were that the students must be considered international students by the university and must be able to effectively communicate in English. The students completed a fourteen-question survey questionnaire which asked about demographic data as well as questions about attitudes and beliefs about …


Cardiovascular Medical Nutrition Therapy Looking At The Dash Trials, Rachel Anne Naegle May 2005

Cardiovascular Medical Nutrition Therapy Looking At The Dash Trials, Rachel Anne Naegle

Undergraduate Honors Capstone Projects

OBJECTIVE: To review the recent medical literature on the effects of the DASH diet principles of increased fruits, vegetables, low-fat dairy, and decreased total and saturated fat; focusing on the intent to implement this dietary pattern to reduce hypertension, and thus to reduce cardiovascular disease.

FINDINGS: The combination diet reduced systolic by 5.5 mm Hg, and diastolic by 3.0 mm Hg as compared to the control diet (P<0.001 for each) (5, 7, 8). When comparing the two diet variables, the combination diet reduced systolic blood pressure 2.7 mm Hg, and diastolic 1.9 mm Hg more than the fruits-and-vegetables diet, (all with a P<0.001)! The results of the DASH-sodium (DASH II), proved also to substantially lower blood pressure when used with the combination diet.

CONCLUSION: Even though the DASH-sodium diet did decrease blood pressure, there is no scientific background to recommend this to all populations, and that instead of focusing attention on reducing sodium, efforts should …


Hunger And Satiety In Recovering Eating Disorder Patients, Jenelle T. West May 2005

Hunger And Satiety In Recovering Eating Disorder Patients, Jenelle T. West

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Desire to eat, hunger, feeling of having enough to eat, and fullness were measured in 11 eating disorder patients in treatment for less than two months, 7 eating disorder patients in treatment for more than two months, and 11 controls. The experimental group was female patients with a DSM-IV diagnosis of Anorexia Nervosa, Bulimia Nervosa, or eating disorder not-otherwise-specified. The experimental and control groups ate a test meal two hours after a preload. The groups answered four questions about desire to eat, hunger, feeling of having enough to eat, and fullness, before they ate, halfway through their meal, immediately upon …


Nutritional Status And Growth In Infants With Cystic Fibrosis At Diagnosis And At Age Two Years And Six Years, Marianne Rich May 2005

Nutritional Status And Growth In Infants With Cystic Fibrosis At Diagnosis And At Age Two Years And Six Years, Marianne Rich

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

PURPOSE: A retrospective chart review was conducted to determine if nutritional source of feeding and/or infant age at diagnosis of cystic fibrosis had any effect on nutritional status and subsequent growth accretion. Additionally, an attempt was made to identify predictors for poor growth in patients with undiagnosed cystic fibrosis.

METHODS: Data was collected from medical and clinic charts at Primary Children's Medical Center (PCMC), Salt Lake City, Utah, for subjects born between January 1, 1995 and December 31, 200 I, who were diagnosed with cystic fibrosis before 1 year of age. Thirty-one subjects met inclusion parameters. These subjects were divided …


Weight Maintenance: Determinants Of Success, Cynthia Mitchell May 2005

Weight Maintenance: Determinants Of Success, Cynthia Mitchell

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This literature review was a selective examination of current obesity and physical activity research and opinions. Its purpose was more to evoke thought and discussion regarding the United States' obesity epidemic, rather than serve as an exhaustive account of prospective causes and solutions. Obesity and physical inactivity are major preventable health problems in the United States, but despite overwhelming evidence regarding the benefits of a healthy weight and regular physical activity, adult, childhood and adolescent obesity rates continue to escalate, creating significant health, medical and economic consequences.

While obesity rates soar, a small population percentage has proven successful in long-term …


Development And Evaluation Of An Electronic Food Frequency Questionnaire For Estimating Calcium Intake Among Multiethnic Youth, Siew Sun Wong May 2005

Development And Evaluation Of An Electronic Food Frequency Questionnaire For Estimating Calcium Intake Among Multiethnic Youth, Siew Sun Wong

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Youth consuming inadequate amounts of calcium are at risk of developing osteoporosis later in life. To better assess dietary calcium intakes and the efficacy of dietary intervention strategies to improve bone health among youth, it is important to develop calcium intake assessment tools that are reliable, accurate, and interactively engaging for a new generation of youth who have a higher computer literacy and are more technologically knowledgeable than preceding generations. The goal of this dissertation was to develop and evaluate an electronic food frequency questionnaire (eFFQ) that measures calcium intake among 11-to 18-year-old Asian, Hispanic, and White youth. Enhancing this …


Prevention Of Childhood Obesity Among Low-Income Preschool-Aged Children, Ann Romero May 2005

Prevention Of Childhood Obesity Among Low-Income Preschool-Aged Children, Ann Romero

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

To determine the effects of a targeted curriculum and dual program involvement on childhood overweight status among low-income preschool children, a nutrition curriculum was developed. Three Special Supplemental Food Program for Women Infants and Children (WIC) clinics participated in the study: the control clinic, a clinic which received the targeted curriculum, and a third clinic which received the targeted curriculum and referred participant families to the Expanded Food and Nutrition lll Education Program (EFNEP). Participants were followed for six months. Data collected included anthropometrics, dietary intake, and parental behaviors.

Results showed a decrease in body-mass index percentile, slight improvements in …


Evaluation Of Antioxidant Effectiveness And Sensory Attributes Of Chinese 5-Spice Ingredients In Cooked Ground Beef, Saumya Dwivedi May 2005

Evaluation Of Antioxidant Effectiveness And Sensory Attributes Of Chinese 5-Spice Ingredients In Cooked Ground Beef, Saumya Dwivedi

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This study determined antioxidant and sensory effects of cinnamon, cloves, fennel, pepper, and star anise (Chinese 5-spice ingredients) in cooked ground beef. In experiment 1, thiobarbituric acid (TBA) values of cooked samples were measured during refrigerated storage. In experiment 2, trained panelists evaluated cooked samples for rancid, beef, and spice flavor intensity. Total aerobic plate counts were also measured.

Mean TBA values were high (3.4) for control samples. In previous studies, TBA values >1.0 were associated with unacceptably rancid cooked meats. At the lowest spice level of 0.1% of meat weight, all spices except pepper had lower TBA values than …


Diabetes, Cognitive Decline, And Alzheimer's Disease: The Cache County Study On Memory, Health, And Aging, Gene Charoonruk May 2005

Diabetes, Cognitive Decline, And Alzheimer's Disease: The Cache County Study On Memory, Health, And Aging, Gene Charoonruk

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Studies have reported mixed results for people with or without diabetes with cognitive decline or Alzheimer's disease (AD). Cognitive decline and AD among people with diabetes will be the focus of much discussion since results have been controversial.

The study examined whether diabetes is associated with cognitive decline and whether it is an independent risk factor for the development of AD among elderly residents of Cache County, Utah.

Results revealed an association between diabetes and a lower average Modified Mini Mental State Examination (3MS) score of nearly a point lower at baseline. Results also showed an association between diabetes and …


Identification Of Factors Affecting Susceptibility To Depression And Influencing Quality Of Life In Adult Cystic Fibrosis Patients Based On Age-At-Diagnosis, Marlene Israelsen May 2005

Identification Of Factors Affecting Susceptibility To Depression And Influencing Quality Of Life In Adult Cystic Fibrosis Patients Based On Age-At-Diagnosis, Marlene Israelsen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Approximately 10% of cystic fibrosis (CF) cases remain undiagnosed until age 18 or later and medical professionals are still unclear about the needs of these individuals. Adults with CF must either adapt to life with a chronic disease or transition into adulthood with CF. The purpose of this study was to address the impact of age-at-diagnosis on quality of life in a CF adult population.

The psychological functioning of 21 adult CF patients (seven adult-diagnosed (AD) and 14 pediatric-diagnosed (PD)) was assessed using the Beck Depression Index (BDI)-II. A descriptive review of demographic and clinical data, which included an assessment …


Nutrition Education For Parents Of Children With Cystic Fibrosis : Assessment Of Needs And Strategies For Improved Knowledge And Confidence In Self Care, Catherine M. Mcdonald May 2005

Nutrition Education For Parents Of Children With Cystic Fibrosis : Assessment Of Needs And Strategies For Improved Knowledge And Confidence In Self Care, Catherine M. Mcdonald

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Suboptimal growth and nutritional status are problematic for children with cystic fibrosis (CF). Optimal nutrition predicts better lung function and longevity. Daily nutrition therapy for children with CF requires adequate food resources, knowledge of appropriate nutrition and behavior management skills, and confidence in one's ability to correctly apply the necessary skills. The Mountain West Cystic Fibrosis Consortium Questionnaire (MWCFC-Q) was designed as an educational needs assessment for parents of children with CF. The goal was to identify areas of concern that could be targeted for educational intervention to ultimately improve children's growth and nutritional status.

Data analyzed from 305 returned …


Hiv And Nutrition: Pregnant And Lactating Women, Peggy Papathakis, Nigel Rollins Apr 2005

Hiv And Nutrition: Pregnant And Lactating Women, Peggy Papathakis, Nigel Rollins

Food Science and Nutrition

No abstract provided.


The Effect Of Religiosity And Spirituality On Transformatinal Leadership Characteristics Of Hospital Food And Nutrition Managers, Anna Naegle Sarver Mar 2005

The Effect Of Religiosity And Spirituality On Transformatinal Leadership Characteristics Of Hospital Food And Nutrition Managers, Anna Naegle Sarver

Theses and Dissertations

Effective leadership in the field of dietetics is becoming increasingly vital in a rapidly changing world. A determination of factors which impact leaders and their followers is essential. This study was designed to examine the relationship between religiosity and spirituality and transformational leadership characteristics of hospital food and nutrition managers as rated by self as well as by those directly supervised by the managers. The influence of religious and spiritual beliefs on the workplace and workplace practices was also examined. Respondents were selected from the American Hospital Association database. Hospitals from 250 to 499 beds were included. Directors of Foodservice …


Gertrude Applebaum, Gertrude Applebaum, Institute Of Child Nutrition. Child Nutrition Archives. Jan 2005

Gertrude Applebaum, Gertrude Applebaum, Institute Of Child Nutrition. Child Nutrition Archives.

Oral History Project (all interviews)

Gertrude Applebaum devoted forty-seven years of her illustrious career to the Corpus Christi School District, forty of which were spent as Food Service Director, and then seven as Assistant Superintendent. Soon after becoming a member of the child nutrition profession Ms. Applebaum attended the meeting in Chicago where Food Service Directors and the National School Cafeteria Association voted to merge and form the American School Food Service Association. She served as President of this organization, now known as the School Nutrition Association, in 1981-82.


Discovery: The Student Journal Of Dale Bumpers College Of Agricultural, Food And Life Sciences - Volume 6 2005, Several Authors Jan 2005

Discovery: The Student Journal Of Dale Bumpers College Of Agricultural, Food And Life Sciences - Volume 6 2005, Several Authors

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

No abstract provided.


Letter From The Dean, Gregory J. Weidemann Jan 2005

Letter From The Dean, Gregory J. Weidemann

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

No abstract provided.


Contents, Discovery Editors Jan 2005

Contents, Discovery Editors

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

No abstract provided.


Instructions For Authors, Discovery Editors Jan 2005

Instructions For Authors, Discovery Editors

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

No abstract provided.


Prediction Of The Tenderness Of Cooked Poultry Pectoralis Major Muscles By Near-Infrared Reflectance Analysis Of Raw Meat, Bradley R. Cheatham Jan 2005

Prediction Of The Tenderness Of Cooked Poultry Pectoralis Major Muscles By Near-Infrared Reflectance Analysis Of Raw Meat, Bradley R. Cheatham

Inquiry: The University of Arkansas Undergraduate Research Journal

Tenderness in boneless poultry breast meat is of utmost importance to consumers. However, there is currently no nondestructive method to predict poultry breast meat tenderness. Textural properties of poultry breast meat were predicted by near-infrared reflectance (NIR) spectroscopy. Spectra were collected on 390 poultry Pectoralis major muscles from broiler carcasses to examine the correlation between NIR spectroscopy and the Meullenet-Owens Razor Shear (MORS) test. Two instrumental parameters (maximum shear force and total shear energy) were used as estimates of meat tenderness. Calibration (R2 cal) and validation (r2 val) coefficients of determination were used for predicting instrumental measurements using the reflectance, …


Effect Of Calcium Lactate On Quality, Safety And Nutritional Senescence Parameters Of Minimally Processed Vegetables, Ana Belen Martin-Diana, Daniel Rico, Jesus Maria Frias, Jemina Mulcahy, Gary Henehan, Catherine Barry-Ryan Jan 2005

Effect Of Calcium Lactate On Quality, Safety And Nutritional Senescence Parameters Of Minimally Processed Vegetables, Ana Belen Martin-Diana, Daniel Rico, Jesus Maria Frias, Jemina Mulcahy, Gary Henehan, Catherine Barry-Ryan

Articles

Calcium lactate maintained quality senescence indicators, as well as chlorine in Iceberg lettuce, and enhanced nutritional values during storage in sliced carrots better than chlorine. Colour and texture objective measurements did not show differences between treatments for Iceberg lettuce; however there were differences in colour in sliced carrots, showing greater change in colour values in samples treated with chlorine. Calcium lactate washing treatments prevented the bleaching effect on saladcut lettuce and sliced carrots and also diminished the appearance of white surfaces over storage. The ascorbic acid decreased during storage independently of the type of treatment used for both vegetables, however …


Novel Washing Methods To Extend The Quality And Enhance The Nutritional Value Of Minimally Processed Vegetable Products, Ana Belen Martin-Diana, Daniel Rico, Jesus Maria Frias, Jemina Mulcahy, Gary Henehan, Catherine Barry-Ryan Jan 2005

Novel Washing Methods To Extend The Quality And Enhance The Nutritional Value Of Minimally Processed Vegetable Products, Ana Belen Martin-Diana, Daniel Rico, Jesus Maria Frias, Jemina Mulcahy, Gary Henehan, Catherine Barry-Ryan

Articles

This paper reports on the development of alternative washing treatments to extend the quality and safety of fresh cut-vegetables and improve their nutritional value. Washing with Ca-lactate (3%) prevented the bleaching effect on salad-cut lettuce and sliced carrots and the appearance of whiteness on the second one normally associated with sodium hypochlorite washing solutions (120 ppm Chlorine). Ca-lactate maintained and enhanced nutritional values during storage, especially in carrots. Sliced carrots treated with Ca-lactate had significant (p


Optimisation Of Calcium Lactate Washing Treatment On Salad-Cut Lettuce: Quality Aspects, Ana Belen Martin-Diana, Daniel Rico, Catherine Barry-Ryan, Jesus Maria Frias, Jemina Mulcahy, Gary Henehan Jan 2005

Optimisation Of Calcium Lactate Washing Treatment On Salad-Cut Lettuce: Quality Aspects, Ana Belen Martin-Diana, Daniel Rico, Catherine Barry-Ryan, Jesus Maria Frias, Jemina Mulcahy, Gary Henehan

Articles

Markers of quality retention: colour, texture, browning, texture related enzymes and sensory properties, were analysed during storage. The use of high temperatures (50ºC) showed a positive effect on enzymes related to quality maintenance. It reduced the activity of the browning-related enzymes polyphenol oxidase and peroxidase but it increased the activity of pectin methyl esterase, an enzyme involved in the maintenance of texture. High calcium lactate concentrations (3 %) produced a reduction in the respiration rate of the salad-cut lettuce during storage, but also a loss of luminosity and greenness (a*). The use of high temperatures and intermediate calcium lactate concentrations …


Effect Of Temperature On The Kinetic Behaviour Of Polyphenol Oxidase And Peroxidase In Fresh-Cut Lettuce, Ana Belen Martin-Diana, Daniel Rico, Catherine Barry-Ryan, Jemina Mulcahy, Gary Henehan, Jesus Maria Frias Jan 2005

Effect Of Temperature On The Kinetic Behaviour Of Polyphenol Oxidase And Peroxidase In Fresh-Cut Lettuce, Ana Belen Martin-Diana, Daniel Rico, Catherine Barry-Ryan, Jemina Mulcahy, Gary Henehan, Jesus Maria Frias

Articles

Activity levels for polyphenol oxidase (PPO) and peroxidase (POD) enzymes were exanimate in crude extracts and showed significantly higher values in photosynthetic tissue than in vascular tissue. Time courses at 50 ºC showed a rapid loss of POD activity and a similar but slower loss of PPO activity in all tissue while incubations at 4 ºC and 25 ºC showed no significant loss of activity over the same time period. The thermal treatment of the extracts (50 ºC) caused a decrease in the PPO and POD activities over time, in all the samples. PPO had less dependence on temperature than …


Effects Of Heating On Hydrophobicity, Viscosity, And Gelling Properties Of Soy Products, Robert S. Walnofer, Navam S. Hettiarachchy, Ronny Horax Jan 2005

Effects Of Heating On Hydrophobicity, Viscosity, And Gelling Properties Of Soy Products, Robert S. Walnofer, Navam S. Hettiarachchy, Ronny Horax

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

The co-product of soybean after oil extraction is the meal, which is rich in protein. From this meal, protein concentrate and protein isolate are prepared and are commercially available as functional ingredients. Thermal treatment is the most common step applied to foods during processing. Changes in structural and functional properties can be affected by thermal or chemical treatments. The objective of this study was to evaluate the effect of heat on surface hydrophobicity, gelling properties, and viscosity of soy meal (SM), soy protein concentrate (SPC), and soy protein isolate (SPI). The soy products were subjected to heat at varying temperatures …


Living Digestibility Of Alfalfa And Barley In Llamas (Lama Glama) In The Agricultural Experimental Center Condoriri, Adelaida Alarcon Chuquichambi Jan 2005

Living Digestibility Of Alfalfa And Barley In Llamas (Lama Glama) In The Agricultural Experimental Center Condoriri, Adelaida Alarcon Chuquichambi

Theses and Dissertations

The following investigation was carried out in the Agricultural Experimental Center Condoriri (CEAC), dependent on the Faculty of Agricultural Livestock Sciences and Veterinary Medicine, located to the North of the Province border of the Department of Oruro, a distance of 12 km from the town of Caracollo and 49 km from the city of Oruro. The production of llamas and alpacas in our country is an activity of ecological, social, and especially ecological importance for Andean inhabitants. In nutrition, the fundamental factor is the power of absorption; this is because the yield of animal production depends on the quantity and …


Ctla-4 Signaling Regulates The Intensity Of Hypersensitivity Responses To Food Antigens, But Is Not Decisive In The Induction Of Sensitization, Femke Van Wijk, Sanne Hoeks, Stefan Nierkens, Stef J. Koppelman, Peter Van Kooten, Louis Boon, Leon M.J. Knippels, Raymond Pieters Jan 2005

Ctla-4 Signaling Regulates The Intensity Of Hypersensitivity Responses To Food Antigens, But Is Not Decisive In The Induction Of Sensitization, Femke Van Wijk, Sanne Hoeks, Stefan Nierkens, Stef J. Koppelman, Peter Van Kooten, Louis Boon, Leon M.J. Knippels, Raymond Pieters

Department of Food Science and Technology: Faculty Publications

Although food allergy has emerged as a major health problem, the mechanisms that are decisive in the development of sensitization to dietary Ag remain largely unknown. CTLA-4 signaling negatively regulates immune activation, and may play a crucial role in preventing induction and/or progression of sensitization to food Ag. To elucidate the role of CTLA-4 signaling in responses to food allergens, a murine model of peanut allergy was used. During oral exposure to peanut protein extract (PPE) together with the mucosal adjuvant cholera toxin (CT), which induces peanut allergy, CTLA-4 ligation was prevented using a CTLA-4 mAb. Additionally, the effect of …


Accumulation Of Retinol In The Liver After Prolonged Hyporetinolemia In The Vitamin A-Sufficient Rat, Sin Gieng, Jens Raila, Francisco Rosales Jan 2005

Accumulation Of Retinol In The Liver After Prolonged Hyporetinolemia In The Vitamin A-Sufficient Rat, Sin Gieng, Jens Raila, Francisco Rosales

Faculty Publications

We assessed the effects of prolonged reduction of plasma retinol concentrations (hyporetinolemia) on the distribution of tissue vitamin A (VA) and of its active compounds using a model of continuous recombinant human interleukin-6 (rhIL-6) infusion via osmotic minipumps in VA-sufficient male rats. Plasma retinol and retinol-binding protein (RBP) concentrations remained decreased and lower in rhIL-6-treated rats compared with controls from 7.5 h throughout 7 days of infusion (P < 0.001). This reduction was accompanied by a 68% increase in hepatic retinol concentration by 7 days (P < 0.05). Hepatic and renal retinyl palmitate and retinoic acid concentrations did not change, and renal megalin content remained unchanged; hepatic RBP concentrations were 41% lower in rhIL-6-treated rats compared with controls (P < 0.05). These results indicate that instead of being lost, retinol accumulated in the liver during inflammation and that hyporetinolemia was attributable to a decrease in the availability of hepatic RBP. A plausible consequence of the effect of rhIL-6-induced hyporetinolemia is that by 7 days tissues that are dependent on plasma retinol may become deprived of VA.These results have important implications in understanding the mechanism by which measles infection induces hyporetinolemia and VA deficiency of extrahepatic tissues.