Digital Commons Network^™

Membrane-Engineered Nanotherapeutic Platforms For Drug Delivery: Hollow Fiber Membrane Synthesis Of Lipid Nanoparticles, Biomimetic Nanocarriers, And Nanobubbles, Zhixiang Liu

Dissertations

Lipid-based nanocarriers have emerged as a cornerstone technology for RNA therapeutics, enabling effective intracellular delivery for applications ranging from vaccination to gene regulation. However, current manufacturing approaches, particularly microfluidic-based platforms, face inherent limitations in scalability, throughput, and structural tunability due to their reliance on confined channel geometries and restricted mixing architectures. Addressing these challenges requires fundamentally new strategies that decouple nanoparticle formation from traditional microscale flow constraints while maintaining precise control over physicochemical properties.

This dissertation presents a comprehensive framework for the design, engineering, and application of advanced lipid-based nanocarriers, centered on a hollow fiber membrane (HFM)—assisted nanopore-mediated assembly platform. …

Transcranial Ac Modulation Of Cerebellar Nuclear Activity In Awake Animals, Nuran Kavakli

Dissertations

Entrainment of cerebellar nuclear (CN) cells via cerebellar transcranial alternating current stimulation (ctACS) has been reported in animals under ketamine/xylazine anesthesia. Our main objective was to demonstrate modulation of CN activity in unanesthetized, freely moving animals using ctACS. Multi-channel carbon-fiber electrodes were implanted into the interpositus nucleus for recording multi-unit (MU) activity, and thin-film electrodes were implanted subcutaneously over the posterior cerebellum for stimulation. A frequency-domain-based metric was developed to quantify modulation from MU signals. The results demonstrated modulation in a wide range of frequencies (4 Hz-300 Hz) as in anesthetized animals. In contrast, the amplitude of the peak in …

Autonomous Exploration Of An Environment With Static Obstacles Using A Ppo Agent, Brandon Knight

Theses

Research in autonomous exploration has created many effective algorithms that have been tested and proven to work in many different virtual and physical environments. Many optimizations have also been developed to reduce computational effort and increase exploration speed.

However, despite optimizations, these algorithms can still require considerable computational effort and time to explore even small environments. To obtain further improvements in computation and exploration speed, a reinforcement learning agent using actor-critic style proximal policy optimization (PPO) is trained to explore various environments efficiently, then compared to an algorithm using contemporary exploration methods.

Testing is performed in virtual environments with ideal …

Retinomorphic Mid-Wave Infrared In-Sensor Processing Engine: Device-To-Architecture Co-Design, Hemalatha Nagaraju

Theses

Conventional frame-based CMOS image sensors acquire full-frame pixel data at discrete time intervals, resulting in substantial spatial redundancy and loss of temporal information between frames. The repeated conversion and transfer of redundant pixel data increases bandwidth and power consumption in machine vision systems. Retinomorphic sensing architectures address these limitations by enabling programmable, analog-domain processing directly at the sensor interface. A compact behavioral model of the PbSe device is developed in HSPICE based on calibrated TCAD simulation data to capture gate-controlled photocurrent modulation under varying illumination and gate bias conditions. Error analysis is performed to quantify the deviation between TCAD-generated photocurrent …

Engineering: What Are We Doing?, Matthew Kuperus Heun

University Faculty Publications and Creative Works

Keynote speech at 2026 Christian Engineering Society Conference and 2026 Association for Christians in Mathematical Sciences Conference

The Impact Of Climate Change On Glass Facades: A Bibliometric Analysis, Pelin Akın, Güneş Mutlu Avinç

HBRC Journal

Climate change has direct impacts on the design and performance of building envelopes, necessitating new approaches in the discipline of architecture. In this study, a bibliometric analysis was conducted to understand the effects of climate change on glass façade systems. The 612 academic publications obtained from the Web of Science database were analyzed through R Studio Biblioshiny. Within the scope of the study, publication trends, key themes, prominent authors, institutions and geographical distributions were evaluated in detail. According to the findings of the research, it was indicated that research has gained momentum especially after 2016, focusing on themes such as …

Sealing Performance Evaluation Criteria And Profile Optimization Of The Volumetric Cavities Of Positive Displacement Motors For Directional Drilling, Kuang Yuchun, Hu Xin, Zhou Jingpei, Luo Jinwu, Liu Yihui, Han Yiwei

Coal Geology & Exploration

Objective Constrained by complex stratigraphic conditions in underground coal mines, directional drilling faces challenges such as low efficiency when encountering medium-hard and hard formations. Positive displacement motors (PDMs) with a diameter of 89 mm are commonly used for directional drilling. Their efficiency is primarily influenced by the sealing performance of their volumetric cavities, which further significantly affects the drilling efficiency. Methods Based on the structural characteristics of the three-dimensional (3D) volumetric cavities of PDMs and the simulation method of two-way fluid-structure interactions, this study proposed the criteria for quantitatively evaluating the efficiency and volumetric cavity performance of PDMs, followed by …

Construction Project Administration: Course Portfolio, Andre Messner

UNL Faculty Course Portfolios

This portfolio presents a structured framework for the design and implementation of a construction project administration course within a Construction Management program. Emphasis is placed on aligning student learning objectives, instructional strategies, and assessment methods with current industry expectations and professional standards. The course is intentionally designed to bridge the gap between theoretical knowledge and practical application by incorporating real-world scenarios, collaborative learning environments, and experiential activities that mirror industry practices.

In addition to outlining the course structure, this paper examines the pedagogical foundations that support student-centered learning, including constructivism, scaffolding, and project-based learning. These approaches are used to foster …

Stoker-Fired Laboratory Boiler As A Tool For Optimising The Solid Fuel Combustion Process, Przemysław Rompalski, Justyna Guzy-Proc, Mariusz Kieczek

Journal of Sustainable Mining

This paper presents the results of quality testing performed on a stoker-fired laboratory boiler to present the technical potential of the boiler as a tool for optimising the combustion process of prepared solid fuels (granulate, energy blend) in the context of current demands related to the decarbonisation policy. The comprehensive testing of such fuels at a laboratory scale makes it possible to gain deep insights into the quality parameters of the fuel, flue gas and combustion waste, as well as to determine the combustion process parameters before the fuel is introduced for combustion in broader power engineering and household boilers. …

How Fe(Ii)/2-Oxoglutarate Oxygenase Chooses Chlorination Over Hydroxylation: Electric Field-Driven Ligand Exchange Governs C-Cl Formation, Simahudeen Bathir Jaber Sathik Rifayee, Midhun George Thomas, Anandhu Krishnan, Kritika Gupta, Carter Davis, Tatyana Karabencheva-Christova, Christo Z. Christov

Michigan Tech Publications

Non-heme Fe(II)/2-oxoglutarate (2OG)-dependent halogenases catalyze highly selective C-H halogenation. BesD is a non-heme Fe(II)/2OG halogenase that performs regio- and stereoselective chlorination of the l-lysine (l-Lys) substrate. Understanding the mechanism by which halogenation is favored over canonical hydroxylation is essential for guiding enzyme engineering efforts aimed at converting hydroxylases into halogenases. Here, we combine molecular dynamics (MD) and hybrid quantum mechanics/molecular mechanics (QM/MM) calculations to elucidate the origin of chlorination selectivity in BesD and variants derived from a homologous hydroxylase. Our results indicate that, although the initial inline Cl-Fe(III)-OH intermediate is inherently predisposed toward hydroxylation, it undergoes a two-step isomerization in …

Decision Making At Triage Classification Using Svm With Smote Technique, Mehanas Shahul, Pushpalatha Kp

Northeast Journal of Complex Systems (NEJCS)

The efficient functioning of triage gates in overcrowded emergency departments (EDs) occurs in the context of the complex adaptive system (CAS) framework, where diverse system elements – patients, medical personnel, resources, patients’ inflow patterns, and patients themselves – simultaneously and dynamically influence the decision process. This study addresses the automated incorporation of machine learning triage algorithms as part of the system triage process to support automated classified risk-level recognition based on a limited set of vital signs. Patients are dynamically subsumed under high and low-risk categories enhanced by sensitivity, which enables optimal diagnosis and triage response to the critical clinician …

Material Costs, Karima Weinman

Masters Theses

This thesis investigates how migration fatality and disappearance data can be reinterpreted through material craft to create a more reflective encounter with information. Working with the Missing Migrants Project's dataset, this project asks how design can communicate dimensions of human loss that conventional data visualization cannot reach.

The work situates contemporary border violence within a longer colonial history, arguing that the logics of surveillance and quantification that structured European imperial expansion persist in the databases that govern mobility in the Mediterranean today.

Terrazzo is a 15th-century Venetian flooring technique built from discarded fragments bound together into a unified surface. This …

Sentience, Sheetal Agrawal

Masters Theses

The increasing urgency for sustainable and adaptive systems has driven research toward embedding intelligence directly into materials rather than relying solely on external sensing and control systems. This thesis explores how smart material1 embedded systems can be designed to recognize and respond to environmental signatures, defined as measurable patterns such as temperature fluctuations and mechanical forces. Central to this investigation is the integration of shape memory alloys, particularly Nitinol, with geometry-based actuation mechanisms that amplify material behavior into functional system responses.

The central argument is that designing with smart materials is a design problem, not primarily a materials science problem …

Les Grands Chantiers De La Transition Énergétique Au Maroc: Le Cas De Dakhla-Oued Eddahab Entre Réalisations, Facteurs De Réussite Et Perspectives, Limam Boussif, Jalila Ait Soudane

Journal of Maya Heritage

Résumé: Cet article examine la dynamique de la transition énergétique au Maroc à travers une analyse descriptive et analytique du cas de Dakhla-Oued Eddahab. Dans un contexte marqué par l’accélération des politiques de décarbonation à l’échelle mondiale, le Maroc s’impose comme un acteur stratégique en matière de développement des énergies renouvelables et de l’hydrogène vert. L’étude met en lumière les principaux chantiers structurants engagés dans la région de Dakhla, notamment le développement des énergies éolienne et solaire, les projets de production d’hydrogène vert, le dessalement de l’eau de mer, ainsi que la réalisation du port Dakhla Atlantique. L’analyse montre que …

Characterization And Potential Suitability Of Some Egyptian Clays For Ceramic Building Applications, Marwa Askar, Medhat Sobhy El-Mahllawy, Mohamed Hamed Abdel-Aal, Ali Mohamed Ali Abd-Allah, Safia Gaber Al Menoufy

HBRC Journal

This study investigates the suitability of five Egyptian clay deposits—Wadi El-Natrun, Qasr El-Sagha, Kafr Homied, Fayed, and Suez Road—for ceramic building applications. Representative samples were characterized chemically and mineralogically, with grain size distribution and Atterberg limits determined to assess their industrial potential. Mineralogical analysis identified montmorillonite, illite, and kaolinite as the dominant clay minerals. Grain size and plasticity data, plotted on industrial diagrams, revealed that all samples are highly plastic clays with elevated clay fractions and minimal sand content. Such properties, while beneficial for molding, require modification to reduce excessive plasticity. The addition of non-plastic materials is recommended to enhance …

In Silico Molecular Docking Study Of Antidiabetic Bioactive Compounds From Brotowali (Tinospora Cordifolia) Targeting Glut4 In Type Ii Diabetes Mellitus, Gita Euaggelion Tarigan, Surya Dwira

Indonesian Journal of Medical Chemistry and Bioinformatics

Type 2 diabetes mellitus (T2DM) is a global metabolic disorder characterized by insulin resistance and impaired glucose uptake. Despite the availability of pharmacological therapies, limitations such as adverse effects and high costs highlight the need for alternative therapeutic candidates. Tinospora cordifolia has been widely reported to contain bioactive compounds with antidiabetic potential; however, comparative evaluation of their interaction with glucose transporter type 4 (GLUT4) remains limited.

This study aimed to identify the most promising bioactive compounds from Tinospora cordifolia targeting GLUT4 using an in silico molecular docking approach, followed by pharmacokinetic and toxicity (ADMET) prediction. Molecular docking was performed using …

From Frames To Strains: Analytically Modeling Inelastic Deformation Under Mapped Single-Site Impacts From High-Speed Footage To Internal State Variable Codes, Joby Milo Anthony

Doctoral Dissertations and Projects

This work adds insight to the physical phenomena of microstructural and stress strengthening of metal components by the inelastic deformation from Surface Mechanical Attrition Treatment (SMAT). Impact behaviors observed by high-speed footage of a Crank-Slider Mechanism (CSM) are examined in the context of analytically moving rigid bodies in spacetime and resolving kinematics upon impact until restitution via Finite Element Analysis (FEA). A Coupled Discrete-Finite Element Model (CDFEM) leverages Bammann plasticity, Horstemeyer damage and void nucleation, growth, and coalescence and Cho recrystallization Internal State Variable (ISV) models to show the localization of plastic strain and onset of recrystallization under any single …

Techno-Economic Assessment And Life Cycle Analysis Of Electrocatalytic Reduction Of Co2 To Ethanol., Omotolani Elizabeth Oduyebo

LSU Master's Theses

This study presents a techno-economic analysis (TEA) and life cycle assessment (LCA) of the electrocatalytic reduction of CO₂ to ethanol, a multi-carbon (C₂) product with significant market value. Prior TEA studies have relied on simplified lump-sum separation cost estimates, and prior LCA studies have rarely examined the combined effect of CO₂ source and electricity supply on carbon intensity gaps that this work addresses through process-simulation-grounded analysis. An Aspen Plus process simulation was developed for an anion-exchange membrane (AEM) electrolyzer system coupled with an extractive distillation separation train using ethylene glycol as the entrainer, achieving 99.9 wt.% ethanol purity …

Predictive Natural Language Metrics Of Alzheimer's Disease And Cognitive Decline Trend Analysis, Zerui Ma

Computer Science and Engineering Theses and Dissertations

Inspired by Dr. David Snowden's Nun Study, which linked early-life Propositional Idea Density (PID) to later-life Alzheimer's disease, this thesis investigates two questions: whether fine-tuned Transformer-based large language models (LLM) can detect cognitive decline from patient speech transcripts with meaningful feature attribution, and whether longitudinal PID trends are observable across large-scale internet and academic text corpora. We evaluate dementia prediction on the DementiaBank Pitt Corpus and conduct an exploratory longitudinal PID analysis across seven diverse datasets spanning up to 29 years and over 12.6 million documents. This work suggests that linguistic ability metrics, traditional PID metrics and novel LLM-based analysis, …

Advanced Finite Element Modeling And Design Enhancement Of Slender Square Concrete-Filled Double-Skin Steel Tubular Columns, Mahmoud T. Nawar, Ayman El-Zohairy, Mohamed Emara, Raghda I. Halima

Faculty Publications

Limited research exists on the behavior of square CFDST slender columns, especially under the consideration of the relation global buckling and confinement effect. This study evaluates square concrete-filled double-skin steel tubular (CFDST) columns using nonlinear finite element analysis (FEA) to simulate structural behavior under axial and eccentric loads until failure. Parametric analyses of extensive specimens of square CFDST pinended columns evaluate various parameters, providing design insights for engineering applications. The study was conducted over a wide range of slenderness ratios. Four concrete varieties with compressive strengths were tested: normal concrete (NC), engineered cementitious composites (ECCs), high-strength concrete (HSC), and ultra-high-strength …

Representativeness And Sensitivity Analysis Of Accident Tolerant Fuel Cladding Behavior In Reactivity-Initiated Accidents, Melissa Andrea Moreno

Nuclear Engineering ETDs

Accident Tolerant Fuels (ATFs) such as FeCrAl are being developed to enhance safety margins in light water reactors during transients like Reactivity Initiated Accidents (RIAs). This dissertation evaluates the accuracy and representativeness of TRACE thermal hydraulic models for predicting FeCrAl C36M cladding behavior under steady state and transient flow boiling conditions. Benchmarking against University of New Mexico separate effects experiments shows that TRACE reproduces key thermal trends but underpredicts cladding temperatures near CHF by approximately 25 to 30%. A calibrated uncertainty and global sensitivity analysis, using Sobol indices, demonstrates that CHF and cladding temperature variability are dominated by mass flux, …

Fault Tolerant Quantum Computing With Lower Overhead, Benjamin E. Anker

Electrical and Computer Engineering ETDs

Quantum computation promises asymptotic speedups over classical algorithms, but realizing these advantages requires overcoming the noisiness of quantum hardware. Although fault-tolerant error correction can allow for reliable quantum computation even using unreliable components, the resource overheads required can substantially erode the asymptotic performance gains. This dissertation focuses on constructing and optimizing fault-tolerant procedures with lower overhead than previous methods were capable of. We present new frameworks for fault-tolerant syndrome extraction using flag gadgets with exponentially reduced ancilla requirements, explicit measurement schedules that achieve asymptotically fewer measurements than stabilizer generators, and a general method for making arbitrary Clifford circuits fault tolerant. …

Investigating Workforce Development Gaps In Tribal Transportation Agencies, Benson Long Jr

Civil Engineering ETDs

Tribal transportation programs face challenges in recruiting and retaining qualified staff, prompting reliance on external consultants for key responsibilities. This study explores how workforce constraints and organizational structures influence tribal outsourcing decisions. Survey data from 57 tribes informed a logistic regression model examining how geographic isolation, population size, training access, and the presence of a transportation department affect preferences for internal work, actual task completion, and instances where tribes intended to perform tasks in-house but outsourced instead. Findings indicate that outsourcing is driven by limited internal capacity, including staffing shortages, lack of certified personnel, and training opportunities. Geography also plays …

Complex-Valued Convolutional Neural Network With Time-Frequency Representation For Electrocardiogram-Based Arrhythmia Detection, Kajeeth Kumar Gurusamy, Muthurajkumar Sannasy

Turkish Journal of Electrical Engineering and Computer Sciences

This research proposes an end-to-end procedure for arrhythmia detection based on electrocardiogram (ECG) signals using complex-valued convolutional neural network (CVCNN) incorporated with time-frequency representation. The proposed model leverages complex numbers to capture amplitude and phase information that enhances the ability of the model for detecting time-frequency variation in cardiac signals. First, signal preprocessing techniques---including normalization, wavelet denoising, and R-peak detection---are applied. Subsequently, the model extracts complex features from raw ECG data by employing the Hilbert transform to derive the analytic signal and the short-time Fourier transform (STFT) to generate a time–frequency representation. The proposed CVCNN framework effectively learns spatial-temporal features …

Experimental Investigation Of The Effectiveness Of Various Stitching Methods On Arresting Mode-Ii Interlaminar Damage Propagation In Geometrically-Scaled Stitched Resin-Infused Composites, Allison Jean White

Theses and Dissertations

This thesis presents an experimental and analytical investigation of mode-II interlaminar fracture in geometrically-scaled quasi-isotropic resin-infused composites, with emphasis on through-thickness stitching as reinforcement. A global-local framework integrating load-displacement response, size effect fracture energy analysis, and digital image correlation-based separation measurements enabled direct comparison between unstitched and stitched configurations. Unstitched laminates exhibited pseudo-ductile behavior but significant post-peak load drops (16.7–26.8%) and a small fracture process zone (FPZ) of 0.73 mm, limiting stable crack growth. Stitching preserved pre-peak stiffness while reducing post-peak load drops by 43–95%, increasing effective fracture energy by 39.7% (to 2.413 N/mm), and expanding the FPZ to 2.85 …

Accurate Diagnosis Of Diseases By A Novel Ai Pipeline Based On Feature Extraction, Feature Ranking, And Feature Selection From Medical Images, Tuğba Nur Bozkurt, Mehmet Emi̇n Yüksel

Turkish Journal of Electrical Engineering and Computer Sciences

The rapid growth of the global population has led to a substantial increase in the number of patients, while the availability of healthcare professionals has not expanded at a comparable rate. This imbalance highlights the urgent need for efficient and reliable computer-aided decision support systems that can reduce clinical workload while maintaining high diagnostic accuracy. In this study, a novel and systematically integrated artificial intelligence-based pipeline is proposed for medical image classification, combining statistical significance-driven feature ranking with evolutionary feature selection in a unified framework. The proposed pipeline consists of four sequential stages: feature extraction, ranking, selection, and classification. Features …

Criticality Safety Evaluation To Address Potential Over Conservative Restrictions In 49 Cfr Fissile Materials – Exceptions, Avian Blumhorst

UNLV Theses, Dissertations, Professional Papers, and Capstones

The U. S. Department of Transportation’s (DOT) 49 CFR 173.453 Fissile Exceptions provide a regulatory classification that helps eliminate burdensome regulatory requirements. The current fissile exceptions are based on past technical basis reviews. These reviews may be overly conservative, and the final ruling potentially applied significant administrative over-conservatism. This thesis reviewed and presents several recommendations to the fissile exception criteria, as well as 49 CFR 173.453 section’s additions.

Using Monte Carlo N-Particle (MCNP) code version 6.3.0, several infinite sea mixtures and array systems were modeled for fissile isotopes 233U and 235U. The research demonstrated that for fissile exception (a) there …

A Review Of Magnesium-Based Stents: Manufacturing Strategies And Future Trends, Amir Motaharinia, Amir Sanati Nezhad, Jeremy Goldman, H. R. Bakhsheshi-Rad, J. Drelich

Michigan Tech Publications

Coronary artery disease is often treated with vascular stents to restore the blood flow. Recently, there has been growing interest in biodegradable metal stents, especially those made from magnesium (Mg). This review starts by explaining the complex pathophysiology of atherosclerosis and the current treatment options. It then discusses stents, including their potential benefits, capabilities, and limitations, as they represent the gold standard for percutaneous coronary intervention in treating atherosclerosis. Given the vital role of stents, we provide a thorough review of the manufacturing techniques involved, such as wire forming, subtractive manufacturing, and additive manufacturing, with a specific focus on stents …

A Study & Comparison Of Lift Boosters For An Unmanned Aerial Vehicle, Trevor Sean Dady

Theses and Dissertations

Unmanned aerial vehicles are becoming increasingly prevalent in modern society for tasks, such as package delivery, defense, and cinematography. Due to this surge in applications, many researchers have begun to search for improvements to unmanned aerial vehicles for their lift and thrust properties. Potential solutions to magnify an unmanned aerial vehicle’s thrust capability are the implementation of Coanda surfaces, nozzles, or bowl-shaped structures on each propeller. Coanda surfaces provide additional lift force by creating a vacuum in response to the adhesion of fluid to the smooth surface. Nozzles can constrict the flow of air, while also increasing its velocity. The …

Karstic Cavities Underground Investigation: Gpr And Geotechnical Data Correlation, Mehrez Jamei, Mabrouk Abdelkader, Anwar Ahmed, Yahya Alassaf

Journal of Sustainable Mining

This paper focuses on the methodology involving ground penetration radar (GPR) for detecting and localizing random cavities in underground limestone soil, in conjunction with geotechnical data. A GPR survey was conducted alongside field and laboratory geotechnical tests at a field where mining activities are now promoted (Saudi Arabia Northern Borders Province). The paper presents correlations between the instantaneous amplitude of the reflected electromagnetic (EM) waves and rock quantification distributed (RQD), recovery rock parameter (REC), and uniaxial compressive strength (UCS). The GPR investigation proved to be an efficient nondestructive geophysical method for determining: 1) the …