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Friend Or Foe? The Role Of Transforming Growth Factor-Β (Tgfβ) Signaling In Calcineurin Inhibitor-Induced Renal Damage, Adaku Uwe

Browse all Theses and Dissertations

With its incorporation into clinical practice in the early 1980s, the class of pharmacological agents known as calcineurin inhibitors (CNIs) quickly became the cornerstone of immunosuppressive therapy post-organ transplantation. However, its use is limited by irreversible kidney damage in the form of renal fibrosis. The molecular mechanism by which CNIs induce renal fibrosis remains to be better understood, and to date, there are no specific therapeutic strategies to mitigate this damage. This dilemma presents a critical need to explain mechanisms by which CNIs cause renal damage. Kidneys of patients on chronic CNI therapy show increased expression of the proinflammatory cytokine …

Advanced Microstructural Characterization Of Functionally Graded Dental Ceramic Material For Materials-Informed Finishing, Angani Vigneswaran

Theses and Dissertations--Manufacturing Systems Engineering

Yttria-stabilized tetragonal zirconia polycrystal (Y-TZP) has gained popularity as the choice of material for dental prosthetics. Ivoclar Vivadent’s IPS e.max ZirCAD Prime dental ceramic incorporates a unique gradient technology that varies the yttria content over the thickness of the material. The top layer is composed of 5Y-TZP which is desired for its optical properties while the bottom layer is composed of a much stronger 3Y-TZP. In between the two layers, 5Y-TZP and 3Y-TZP are mixed to form a transition layer. Varying the amount of yttria allows for more esthetically pleasing translucency in the visible areas of the restoration without compromising …

Efficient 2075-Nm Laser Emission From Ho3+-Doped Fluorotellurite Glass In A Compact All-Fiber Structure, Liyuan Wang, Xiaotong Zhao, Nian Lv, Niannian Xu, Zhenrui Li, Gerald Farrell, Shunbin Wang, Pengfei Wang

Articles

In this Letter, we report an Ho3+-doped fluorotellurite glass all-fiber laser at 2075 nm. The gain fiber is pumped in-band with a 1976-nm fiber laser and connected by fusion splicing. A high-quality fusion splicing point with a loss of < 0.1 dB was obtained by finely adjusting the splicing power and offset. In addition, by optimizing the writing parameters, a third-order fiber Bragg grating (FBG) with a reflectivity of 98% was achieved at 2075 nm using the femtosecond laser direct-writing method. Using the FBG as the laser cavity mirror and a relatively short 28-cm-long home-made Ho3+-doped fluorotellurite fiber as the laser medium, a laser with a maximum unsaturated output power of 7.33 W was obtained, and the corresponding slope efficiency was as high as 93.4%. The first, to the best of our knowledge, demonstration of the fluorotellurite glass all-fiber ∼2.1-µm laser presented in this work may pave the way for a high-power 2.1-µm fiber laser with a compact structure.

Forecasting Covid-19 Cases Using Dynamic Time Warping And Incremental Machine Learning Methods, Luis Miralles-Pechuán, Ankit Kumar, Andres L. Suarez-Cetrulo

Articles

The investment of time and resources for developing better strategies is key to dealing with future pandemics. In this work, we recreated the situation of COVID-19 across the year 2020, when the pandemic started spreading worldwide. We conducted experiments to predict the coronavirus cases for the 50 countries with the most cases during 2020. We compared the performance of state-of-the-art machine learning algorithms, such as long-short-term memory networks, against that of online incremental machine learning algorithms. To find the best strategy, we performed experiments to test three different approaches. In the first approach (single-country), we trained each model using data …

Expression Optimization Of The Gst-Gfp Fusion Protein Through The Alteration Of Induction Conditions, Matthew J. Vaccaro

Honors Undergraduate Theses

This research sought to determine which induction condition resulted in the greatest GST-GFP fusion protein expression. It will hopefully serve as a guide for future researchers trying to produce their own recombinant protein containing GST and GFP-tags. The CDNB Enzyme Assay was used to determine the quantity of GST-GFP fusion protein present and tested three variables: IPTG concentration, duration, and temperature of induction. The findings showed that IPTG concentration, temperature, and induction duration all had a significant impact on protein expression. Induction temperatures of 20 °C and 25 °C showed better protein expression at IPTG concentrations of 1.0 mM IPTG …

Biological Parameters And The Histological Response In Rectal Cancer Treated By Neoadjuvant Chemoradiotherapy: A Moroccan Cohort, A. Naim, N. Bouanani, F. Safini, S. Mounaime, Soumaya Rafii, L. Lachker, F. Guessous, M. Khaliss, N. Tawfiq, A. Badou

Health Sciences

Introduction: Multimodal management of rectal cancer, combining neoadjuvant Radio chemotherapy followed by total Mesorectal therapy (TME), has been shown to improve locoregional control. However, the histological response is variable independently of the initial tumor stage. Some recent data suggest the usefulness of the lymphocyte-monocyte ratio (LMR), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) in predicting the histological response to neoadjuvant therapy. This study aimed to investigate the correlation between the complete histological response (pCR) after neoadjuvant radio chemotherapy and biological parameters (LMR, NLR and PLR) in rectal cancer patients.

PATIENTS AND METHODS: This retrospective study was conducted in three Moroccan …

Internal Structure And Breakage Behavior Of Biogenic Carbonate Sand Grains, Elieh Mohtashami, C. Guney Olgun, Chenglin Wu, Tara Selly

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

This Study Investigates the Mechanical Behavior of Biogenic Carbonate Sands from Puerto Rico at Grain-Scale Level. Micro-Computed Tomography Has Also Been Used to Get Insights on the Internal Structure of These Particles Before and after Loading. the Crushing Strength of These Particles Are Smaller Comparing to the Values Reported for Silica Sands. It Has Also Been Shown that These Particles Have Complex Internal Structure Including a Network of Pores Connected with Channels. This Study Also Demonstrates the Effect of Intragrain Structure of Biogenic Carbonate Sands and Shows How Internal Grain Structure Plays a Role on Particle Fracture.

Using Computational Fluid Dynamics And Optical Sensor Technology To Scale Cell Culture Platforms, Mandar Makwana

KGI Theses and Dissertations

Different cell culture vessels ranging from micro scale to laboratory scale to commercial scale play critical role in upstream process development for biologics manufacturing. Based on the mode of operation, cell culture vessels have different hydrodynamic environments, making it challenging to scale. Integrated approaches using computational tools supported by experimental studies can overcome these challenges. Computational Fluid Dynamics (CFD) is one such tool that can simulate hydrodynamics within the cell culture vessels and can provide insights at macro and micro-scale. Accuracy of a CFD model significantly depends on the fluid model and assumptions. Traditionally, simple two-equation fluid models were developed …

Artificial Emotional Intelligence In Socially Assistive Robots, Hojjat Abdollahi

Electronic Theses and Dissertations

Artificial Emotional Intelligence (AEI) bridges the gap between humans and machines by demonstrating empathy and affection towards each other. This is achieved by evaluating the emotional state of human users, adapting the machine’s behavior to them, and hence giving an appropriate response to those emotions. AEI is part of a larger field of studies called Affective Computing. Affective computing is the integration of artificial intelligence, psychology, robotics, biometrics, and many more fields of study. The main component in AEI and affective computing is emotion, and how we can utilize emotion to create a more natural and productive relationship between humans …

Small-Scale Sustainable Agriculture As A Platform For Experiential Learning, Devin Berg

ASEE North Midwest Section Annual Conference 2023 Publications

Background: Market pressures and the impacts of climate change are threatening the livelihoods of small-holding farmers around the world. As farmers themselves face shortages of workers and the pressures of climate change, adaptation is often required for sustainability. Solutions must be developed in collaboration with local communities to be sustainable, accessible, and equitable.
Method: These challenges provide opportunities for experiential learning within the engineering classroom. In this paper, I describe a diverse set of projects with a sustainable agriculture theme that I have used to enhance student learning through projects implemented in courses, capstone experiences, summer research programs, and independent …

Inspire Newsletter Fall 2023, Missouri University Of Science And Technology. Inspire - University Transportation Center

INSPIRE Newsletters

No abstract provided.

Lipin1 Overexpression Ameliorates The Dystrophic Phenotype In Mdx Mice By Enhancing Myofiber Membrane Integrity, Abdullah Alshudukhi

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Duchenne muscular dystrophy (DMD) is a severe disease characterized by a progressive muscle fiber loss. DMD affects approximately 1 in 3500 male births worldwide. Patients die at early ages due to failure of respiratory and cardiac functions. DMD is caused by mutations in dystrophin gene. Loss of dystrophin leads to disruption of the membrane integrity and necroptosis in skeletal muscles of DMD patients contributing to muscle fiber loss. Currently, effective therapies for DMD have not been established. The goal of this project is to find mechanisms that may improve muscle function/structure despite dystrophin deficiency. Our data show that the expression …

Unfolding The Link Between The Axon Initial Segment, Endoplasmic Reticulum Stress, And Cognitive Impairment In Type 2 Diabetes, Jennae Shelby

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Dementia and mild cognitive impairment are well recognized comorbidities of type 2 diabetes, termed diabetic encephalopathy, that lack in course modifying treatment options. The axon initial segment (AIS) is a critical mediator of neuronal output. Shortening of AIS length has been shown to decrease neuronal excitability and is implicated in diabetic encephalopathy. AIS shortening may be reversible, hence investigating the mechanism responsible could address this significant gap in patient care by providing new therapeutic targets. Endoplasmic reticulum (ER) stress, a cellular condition that activates the unfolded protein response has been implicated in diabetic encephalopathy. Here, using immunocytochemistry in primary mouse …

Rainwater Catchment System In Public Sector Housing, Araceli Peña, Muhammad Yanzar Sarin

2023 REYES Proceedings

Water is a universal right for all living beings on the planet, but today it has become a commercial good. It costs significantly to extract water from increasingly distant storage sources. For these reasons and many more the fight for water has become increasingly intense. Precisely, an alternative to avoid more dam construction is the implementation of public politic with actions focused on the integral solution of water, that is to say, that it be distributed fairly and equitably to all users, avoiding more concessions to great industries like as soft drinks and breweries, which are the main consumers and …

Drawing From Sefi Ethics Knowledge To Support Eco-Ethics Education Within The European University Of Technology, Jye Benjamin O'Sullivan, Shannon Chance

Practice Papers

We are leading a project called Ethico within the European University of Technology (EUt). Ethico aims to design and promote the uptake of innovative, ecological ethics for technological education.

This practice paper briefly summarizes the aims and structure of the Ethico project, and then focuses on the work completed as part of the teacher training module developed in Cluj, 7-9th March, 2023. This workshop drew its conceptual framework from the short abstracts currently available for the Engineering Ethics Education Handbook. The structure developed was then implemented in a student facing workshop in Troyes between the 10-14th July 2023. The handbook …

Conceptual Modelling As An Overarching Research Skill In Engineering Education, Mieke Boon

Practice Papers

Today’s society is impacted by complex, fast and continuously changing problems. These need to be tackled inter-, multi and transdisciplinary. At the University of Twente, we have developed a new CBL minor Intelligence, creativity, and responsible technological innovation in societal transformations, (ICR&TIST), which focuses on research skills in complex socio-technological problem-solving contexts. The design of this minor has been guided by new insights from long-running research aimed at developing a Philosophy of Science for the Engineering Sciences and extensive experiences with engineering education in project-based learning (PjBL). Education in scientific research tends to focus on academic contexts, while scientific research …

The ‘Engineering First Year’: "Step Up" To Success, Nicola Knowles, Jane Andrews, Gill Cooke, Lauren Schrock, Robin Clark, Graeme Knowles

Practice Papers

The nuanced nature of engineering as a profession is highlighted in a recent statement by the EPC (2023) in response to the UCAS publication ‘The Future of Undergraduate Admissions’ (2023). Focusing on the value of Personal Statements within the University Selection System, the EPC asks UCAS to provide more practical information to prospective students about the nature of engineering and what prerequisite qualifications are needed to study engineering. Such clarity is particularly important when considering Engineering Degree Apprentices. Starting with the research question “How can the gap between school and university be bridged in engineering education?” the paper critically discusses …

Innovative Engineering Education In The Wake Of Smart Agriculture. Revision Of The Agricultural Engineering Curriculum, Andreas Mandler, Giovanni Carabin, Lorenzo Becce, Francesco Fabio Nicolosi, Fabrizio Mazzetto

Practice Papers

Global developments request ever more productive agricultural production systems to ensure food security. Agricultural production must be environmentally, socially sustainable and economically efficient. Innovative digital technologies are central to sustainable production systems. This poses challenges to the education of agricultural engineers, as technologies for real world challenges result from highly interdisciplinary innovations.

Agricultural engineering (AgEng) as academic discipline is not universally established, which leaves voids in educational curricula and formal training areas. A substantial conflictual dualism remains between the biological and engineering domains. There are currently no homogeneous pathways through which these domains merge on common scientific and cultural foundations, …

A Game-Based Learning Approach To Enhance Understanding Of Interface Design Principles In Design Education, Deborah Carberry, Colm O'Kane, Kevin Delaney, Ulrich Kruhne, Martin Andersson, Donal Mchale

Practice Papers

The design of user interface is an important and challenging topic for student designers to understand and master. The eight principles of good User Interface (UI) design are often taught using primarily cognitive approaches, which can leave room for improvement in students’ ability to apply the principles in a variety of contexts. Game-based learning tools are recognised to be beneficial in university classrooms across a variety of discipline areas and topics due to their capacity to increase engagement. This project presents a first prototype for an instructional tool that leverages constructionism and embodied learning to enhance students’ understanding and application …

Reshaping The Bio Medical Curriculum To Include Socialisation And Subjectification, Renate Gerarda Klaassen, Linette R.H. Bossen, Costanza Milano, Hans Hellendoorn

Practice Papers

University students are asked to become all-round human beings, knowing how to be engaged in Engineering in the future, as well as wholly socialised and going through personal development steps. However, how and where are the students supposed to acquire these skills? Do we already have them in the Higher Education programmes and curricula? This article explores low threshold steps that can be taken to tweak the curriculum and implicit professionalisation of staff towards incorporating transversal skills and reflective activities that allow students to develop to their full potential.. One is a roadmap Workshop identifying guiding principles and touchpoint activities …

Re/Upskilling The Agricultural Labour Force: Micro-Credentials As Innovative Lll Strategy, Vladana Vidric, Christina Paulus, Simon Grebner, Maximilian Treiber, Martin Mayr, Andreas Mandler

Practice Papers

Industry 4.0 had a strong impact on globalization by changing the workforce and increasing access to new skills and knowledge. According to the World Economic Forum, by 2025, 50% of all employees will need reskilling due to new technology. Industry 5.0 addresses long term prospects such as sustainability, resilience and human-centricity regarding efficiency and productivity. Agriculture is the most exposed economic sector to climate change with cascade effects on agro ecosystems. Innovations in the agricultural sector are inevitable to ensure food security and social and environmental sustainability. This paper presents two Erasmus+ projects that highlight the importance of future engineering …

Academy Presidents And Institutional Members, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

Investigating Michigan’S Skilled Construction Laborer Shortage Within The Great Lakes Region, Jennifer E. Russell

Master's Theses and Doctoral Dissertations

The construction industry has been facing a decline in skilled trade labor for decades. This study asks three overarching questions: (a) What are the causes and influencing factors of Michigan’s skilled construction laborer shortage? (b) How are Michigan stakeholders in the Great Lakes Region remedying the shortage? (c) What new solutions can be implemented to remedy Michigan’s skilled construction laborer shortage? A literature review was conducted to identify causes, influencing factors, and research gaps. Closed surveys questioning 69 construction project managers and 101 skilled trade laborers in Michigan were conducted online and on construction sites. A quantitative analysis of the …

Cancer Immunotherapy: A Breakthrough In Patient Care, Abdou-Samad Kone, Nour El Imane Issam Salah, Amina Ghouzlani, Abdallah Badou

Health Sciences

Cancer is one of the world's leading causes of death. Conventional therapies, such as surgical resection, radiotherapy, and chemotherapy, have improved patient management and have shown overwhelming progress. However, the incidence and mortality rates among cancer patients are still extremely high, at approximately 20,5 % and 10,6 % for both sexes, respectively. This may be due to the heterogeneity of tumors, their special microenvironment, and the development of resistance to certain conventional therapies. The concept of immunotherapy provided a new perspective on patient treatment. The interaction of tumor cells with their microenvironment depends on different factors and conditions that promote …

The “Who” In Engineering: Sociotechnical Engineering As Memorable And Relevant, Diana A. Chen, Marissa H. Forbes, Gordon D. Hoople, Susan M. Lord, Joel Alejandro Mejia

School of Engineering: Faculty Scholarship

Does emphasizing the role of people in engineering influence the memorability of engineering content? This study is part of a larger project through which our team developed a new undergraduate energy course to better reflect students’ cultures and lived experiences through asset-based pedagogies to help students develop a sociotechnical mindset in engineering problem solving. In this study, students in the class were invited to participate in semi-structured interviews (n=5) to explore our effectiveness in helping them develop a sociotechnical mindset around energy issues and conceptualize engineering as a sociotechnical endeavor. This study focuses on an activity during the interview where …

Controlled Release Of Flurbiprofen From 3d-Printed And Supercritical Carbon Dioxide Processed Methacrylate-Based Polymer, Truc T. Ngo, Jae D. Kim

School of Engineering: Faculty Scholarship

The ability to engineer and predict drug release behavior during treatment is critical to the design and implementation of effective drug delivery systems. In this study, a drug delivery system consisting of a methacrylate-based polymer and flurbiprofen was studied, and its release profile in a controlled phosphate-buffered saline solution was characterized. The polymer, which was 3D printed and processed in supercritical carbon dioxide under different temperature and pressure settings, showed sustained drug release over a prolonged period. A computer algorithm was used to determine the drug release time duration before reaching steady state and the maximum drug release at steady …

Bio-Inspired Sutures: Simulating The Role Of Suture Placement In The Mechanical Response Of Interlocking Structures, Melissa M. Gibbons, Diana A. Chen

School of Engineering: Faculty Scholarship

The hardest anatomical components of many animals are connected at thin seams known as sutures, which allow for growth and compliance required for respiration and movement and serve as a defense mechanism by absorbing energy during impacts. We take a bio-inspired approach and parameterize suture geometries to utilize geometric connections, rather than new engineering materials, to absorb high-impact loads. This study builds upon our work that investigated the effects of the dovetail suture contact angle, tangent length, and tab radius on the stiffness and toughness of an archway structure using finite element analysis. We explore how increasing the archway segmentation …

A New Method For Controlling Fractional Linear Systems, Subramanian V. Shastri, Kumpati S. Narendra, Lihao Zheng

School of Engineering: Faculty Scholarship

The study of fractional linear time-invariant (LTI) systems has been an area of active research over the past thirty years. Results indicate that such systems are becoming important in the representation of certain types of dynamical behavior in biology and engineering. Several methods have been developed for the representation, identification, and control of fractional LTI systems. The primary purpose of this paper is to introduce a new approach to their control. Its principal contribution is the transformation of a fractional LTI system into one without fractional terms (standard LTI system) using feedback and feedforward compensation. While the former may be …

Monitoring Blood Flow In Animal Models Using A Camera-Based Technique, Dharminder Singh Langri

Browse all Theses and Dissertations

Blood flow dynamics plays a critical role in maintaining tissue health, as it delivers nutrients and oxygen while removing waste products. It is especially important when there is a disruption in cerebral autoregulation due to trauma, which can induce ischemia or hyperemia and can lead to secondary brain injury. Thus, there is a need for noninvasive techniques that can allow continuous monitoring of blood flow during intervention. Optical techniques have become increasingly practical for measuring blood flow due to their non-invasive, continuous, and relatively lower-cost nature. This research focused on developing a low-cost, scalable optical technique for measuring blood flow …

Radiation Therapy Of Glioblastoma: Experience Of A Moroccan Center, Hassani Wissal, El Ayachi Zineb, Farhane Fatim-Zahra, Alami Zenab, Bouhafa Touria

Health Sciences

Background: Glioblastomas are the most frequent and aggressive primary brain tumors. Their prognosis remains bleak, despite progress in management and understanding of the different biological mechanisms. Our objective is to highlight the impact of radiotherapy in improving the management of glioblastoma through the experience of the radiotherapy department at Hassan II University Hospital. Materials and Methods: This was a retrospective study analyzing the medical records of patients with glioblastoma over the period from August 2012 to January 2020. The data was analyzed using the epi-info software, therapeutic toxicities evaluated according to CTCAE V.4 scale, and overall survival estimated by the …