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Study Of Dry Mixing Method To Apply Microbial-Induced Calcite Precipitation For Soil Treatment, Ruchi Shrestha

Boise State University Theses and Dissertations

Microbially Induced Calcite Precipitation (MICP) has emerged as a promising technique for soil stabilization, traditionally involving the preparation and mixing of treatment solutions with the soil. However, this thesis explores a novel approach of applying MICP by directly mixing dry chemical compounds into the soil and subsequently adding water. This alternative method offers potential advantages in terms of convenience, ease of implementation, and cost savings.

The objective of this research is to investigate the applicability of dry mixing protocols for MICP in soil stabilization. Through comprehensive experimentation, three different dry protocols were developed and applied to five different soils. The …

Phase Distribution Of Nickel, Chromium, And Cobalt In Seawater At Olivine-Enriched Beaches: Implications For Carbon Capture By Enhanced Silicate Weathering, Nathaniel J. Padrnos

Master's Theses

The application of olivine to coastal areas is a proposed method of removing carbon dioxide from the atmosphere for climate change mitigation. Olivine is abundant and dissolves relatively fast, but it contains trace amounts of nickel (Ni), chromium (Cr), and cobalt (Co) which may be toxic to marine biota in cases of widespread coastal olivine spreading. Prior studies have suggested that Ni concentrations in marine sediments and/or the overlying water column due to olivine dissolution could be a limiting factor for its carbon capture potential. Therefore, it is critical to understand and model the processes affecting trace metal bioavailability after …

A Mixed Methods Analysis Of Influences Surrounding Undergraduate Science Recruitment: Identifying Challenges And Opportunities, Evelyn Abagayle Boyd

All Dissertations

Often prevalent in the sciences, undergraduate research experiences (UREs) are highly beneficial engaged learning experiences in higher education. Though the benefits of UREs are well established, there is little information about which students participate in these experiences and the pathways they take to become engaged in them. This study consists of three works which surround the overarching research question: How do undergraduate science students initialize research experiences such that departments and institutions can improve access to these high-impact practices? Utilizing the intersection of the theories of Science Capital and Social Cognitive Career Theory, this study provides insight and recommendations into …

Cad System For Early Diagnosis Of Diabetic Retinopathy Based On 3d Extracted Imaging Markers., Ahmed Sleman

Electronic Theses and Dissertations

This dissertation makes significant contributions to the field of ophthalmology, addressing the segmentation of retinal layers and the diagnosis of diabetic retinopathy (DR). The first contribution is a novel 3D segmentation approach that leverages the patientspecific anatomy of retinal layers. This approach demonstrates superior accuracy in segmenting all retinal layers from a 3D retinal image compared to current state-of-the-art methods. It also offers enhanced speed, enabling potential clinical applications. The proposed segmentation approach holds great potential for supporting surgical planning and guidance in retinal procedures such as retinal detachment repair or macular hole closure. Surgeons can benefit from the accurate …

Heterochiral Dna Nanotechnology For Biomedical Applications, Tracy L. Mallette

Biomedical Engineering ETDs

In the past 30 years, there have been major advancements on how to treat and diagnose disease because of the improvement and increase in accessibility of sequencing technology. Nucleic acid-based therapeutics can manipulate protein expression. Likewise, pathogens can be identified and detected with single nucleotide specificity. However, the underlying oligonucleotide technology requires protection against natural defense systems that have evolved to destroy foreign nucleic acids. Many chemical modifications that can protect nucleotides also have significant cytotoxic side effects and must be carefully designed into the strands. A novel way to protect against nuclease-mediated degradation is through the use of mirror-image, …

Integrating Sensor Development, Risk Assessment, And Community Engagement To Support Environmental Justice In The Rural Community Of El Tiple, Colombia, David Bahamon Pinzon

All Dissertations

In Colombia, ethnic communities have traditionally been responsible stewards of natural resources. They recognize the importance of these resources for their livelihood, as well as their ancestral and cultural heritage. El Tiple, a rural Afro-Colombian community, has been affected by the incursion of private corporations that promoted the expansion of sugarcane monocrops in their territory. Since the introduction of the monoculture industry, local freshwater sources have been depleted due to intensive water use for irrigation of the sugarcane crops. Additionally, the intensive usage of agrochemicals has been linked with loss of native flora, damages to family farms, and pollution of …

Road Map Of Semiconductor Metal-Oxide-Based Sensors: A Review, Taposhree Dutta, Tanzila Noushin, Shawna Tabassum, Satyendra K. Mishra

Electrical Engineering Faculty Publications and Presentations

Identifying disease biomarkers and detecting hazardous, explosive, flammable, and polluting gases and chemicals with extremely sensitive and selective sensor devices remains a challenging and time-consuming research challenge. Due to their exceptional characteristics, semiconducting metal oxides (SMOxs) have received a lot of attention in terms of the development of various types of sensors in recent years. The key performance indicators of SMOx-based sensors are their sensitivity, selectivity, recovery time, and steady response over time. SMOx-based sensors are discussed in this review based on their different properties. Surface properties of the functional material, such as its (nano)structure, morphology, and crystallinity, greatly influence …

Silicon Carbide-Based Dna Sensing Technologies, Abdulla Al Mamun, Mason Mcgarrity, Jong Hoon Kim, Feng Zhao

Electrical and Computer Engineering Faculty Research & Creative Works

DNA sensing is critical in various applications such as the early diagnosis of diseases and the investigation of forensic evidence, food processing, agriculture, environmental protection, etc. As a wide-bandgap semiconductor with excellent chemical, physical, electrical, and biocompatible properties, silicon carbide (SiC) is a promising material for DNA sensors. In recent years, a variety of SiC-based DNA-sensing technologies have been reported, such as nanoparticles and quantum dots, nanowires, nanopillars, and nanowire-based field-effect-transistors, etc. This article aims to provide a review of SiC-based DNA sensing technologies, their functions, and testing results.

Investigation Of Possible Inflammatory Response After Ultrasound And Microbubble Procedure In The Spinal Cord., Jenna Wilkerson

Electronic Theses and Dissertations

The purpose of this experiment is to explore the inflammatory effects of focused ultrasound paired with intravenously delivered microbubbles when used in the lumbar spinal cord. There are currently very few pharmaceuticals that can successfully enter the blood spinal cord barrier (BSCB). This technique used at the lumbar enlargement might allow targeted treatment of pathologies involving the spinal cord.

To test the possible inflammatory response of this technique, an animal experiment was performed. 15 animals were given a T12 laminectomy and allowed to fully recover. Once recovered, all animals received FUS+MB at L2 and were euthanized in groups of five …

Development And Application Of A Microfluidic Platform For Quantifying Intra-Tumoral Compressive Stress., Zachary P. Fowler

Electronic Theses and Dissertations

Cancer progression is linked to the emergence of aberrant mechanical signaling in the tumor microenvironment. Modulation of extrinsic signals, such as ECM stiffness and composition, have been thoroughly explored. However, the development of solid stresses within the tumor remains poorly understood. To address this, we have developed a microfluidic platform that generates deformable alginate microbeads that allow for the quantification of compressive stresses generated within a growing glioblastoma (GBM) tumorsphere. PDMS microfluidic devices were fabricated via SU-8 mold with channels ranging from 10µm-40µm in diameter. Fluorescently labeled sodium alginate underwent a cross-linking reaction within the device to generate monodisperse beads …

Design And Evaluation Of A Multi-Functional Surgical Device For Microgravity Surgeries., Sienna Shacklette

Electronic Theses and Dissertations

No abstract provided.

Integrating Human Psychology Into Car-Following Models For Accurate Response Prediction: A Realistic Approach, Faiza Khan

Masters Theses and Doctoral Dissertations

Car-following models traditionally focus on vehicle kinematics or dynamics parameters without considering human psychology. However, recent research has attempted to incorporate psychology into car-following models. Despite these efforts, there are limitations in understanding the psychological triggers that influence individual drivers' responses. To address this gap, we propose a new car-following model based on the Theory of Planned Behavior (TPB), which incorporates a human element by utilizing concepts of psychology. To gather the data pertaining to human input a questionnaire was carefully developed utilizing the Theory of Planned Behavior. Data collection and analysis were done through a survey using google forms. …

Two-Dimensional Nanomaterials And Nanocomposites For Sensing, Separation, And Energy Applications, Md Ashiqur Rahman

Theses and Dissertations

Two-dimension (2D) nanomaterials have gained popularity for the last few decades due to their excellent mechanical, electrical and thermal properties. These unique properties of 2D nanomaterials can be exploited in various applications specially in sensor, energy, and separation devices. In this study, the sensing and energy generation performance of PVDF/PAni fiber mat systems made by the forcespinning method with and without graphene coating. The graphene-coated nanocomposites show an average output voltage of 75 mV (peak-to-peak) which is 300% higher compared to bare fiber mats and an output current of 24 mA (peak-to-peak) by gentle finger pressing. Moreover, the graphene-coated PVDF/PAni …

Phosphatase And Pseudo-Phosphatase Functions Of Phosphatase Of Regenerating Liver 3 (Prl-3) Are Insensitive To Divalent Metals In Vitro, Jeffery T. Jolly, Ty C. Cheatham, Jessica S. Blackburn

Markey Cancer Center Faculty Publications

Phosphatase of regenerating liver 3 (PRL-3) is associated with cancer metastasis and has been shown to interact with the cyclin and CBS domain divalent metal cation transport mediator (CNNM) family of proteins to regulate the intracellular concentration of magnesium and other divalent metals. Despite PRL-3’s importance in cancer, factors that regulate PRL-3’s phosphatase activity and its interactions with CNNM proteins remain unknown. Here, we show that divalent metal ions, including magnesium, calcium, and manganese, have no impact on PRL-3’s structure, stability, phosphatase activity, or CNNM binding capacity, indicating that PRL-3 does not act as a metal sensor, despite its interaction …

Structures Of The Insecticidal Toxin Complex Subunit Xpta2 Highlight Roles For Flexible Domains, Cole L. Martin, David W. Chester, Christopher D. Radka, Lurong Pan, Zhengrong Yang, Rachel C. Hart, Elad M. Binshtein, Zhao Wang, Lisa Nagy, Lawrence J. Delucas, Stephen G. Aller

Markey Cancer Center Faculty Publications

The Toxin Complex (Tc) superfamily consists of toxin translocases that contribute to the targeting, delivery, and cytotoxicity of certain pathogenic Gram-negative bacteria. Membrane receptor targeting is driven by the A-subunit (TcA), which comprises IgG-like receptor binding domains (RBDs) at the surface. To better understand XptA2, an insect specific TcA secreted by the symbiont X. nematophilus from the intestine of entomopathogenic nematodes, we determined structures by X-ray crystallography and cryo-EM. Contrary to a previous report, XptA2 is pentameric. RBD-B exhibits an indentation from crystal packing that indicates loose association with the shell and a hotspot for possible receptor binding or a …

Examining Biological Algal Harvest For Use In Clemson University’S Algal Carbon Capture System Using Freshwater Mussel Elliptio Complanata, Jack Grimes

All Theses

Capture of atmospheric carbon by freshwater algae is being proposed in Clemson University’s outdoor algal carbon capture system, formerly described as the Partitioned Aquaculture System (Drapcho and Brune, 2000). Several algal species have been present in the system, depending on cultivation conditions. However, mechanical harvesting of the algae has proven difficult because of the cost of chemical flocculants, the energy cost of filtration due to small particle size of algae, and the relatively dilute algal cell concentrations in the system. Prior research on algal filtration by freshwater mussels has indicated its potential for use as a biological filter. This research …

Characterization Of Mechanically Recycled Polylactic Acid (Pla) Filament For 3d-Printing By Evaluating Mechanical, Thermal, And Chemical Properties And Process Performance, Mahsa Shabani Samghabady

All Theses

Polylactic acid (PLA) is a biopolymer made from renewable resources such as sugar and corn. PLA filament is a popular material used in Fused Deposition Modeling (FDM) 3D-printing. While this material has many advantages, all the failed parts, support structures, rafts, nozzle tests, and the many prototype iterations during the 3D-printing process contribute to the plastic pollution and release of greenhouse gases. Although PLA is biodegradable, it can take years to degrade in landfills. Instead of throwing away PLA waste and buying new filaments, PLA can be recycled. Amongst the different recycling technologies, mechanical recycling is the most environmentally friendly. …

Prairie Protector: Student Development Of Systems Thinking Habits In The Context Of Agroecosystems, Erin Ingram, Jennifer Keshwani

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Introduction: The Great Plains ecosystem offers an opportunity for young people to gain knowledge about intricate systems through practical learning. The spread of woody plants into grasslands, known as the “Green Glacier,” poses a risk to biodiversity and animal production. Although effective management strategies exist, some land managers are reluctant to use them. It is critical to cultivate a scientifically literate population that can think systematically and make informed decisions based on STEM principles to address such complex agroecosystem problems.

Methods: In this study, semi-structured focus group discussions with high school students were analyzed to determine whether Prairie …

Systematic Investigation Of Wavy Surface Roughness Profiles Using Common Roughness Algorithms, Russell Gray

Boise State University Theses and Dissertations

Roughness is an important parameter in rock engineering. Sine wave-based simulated wavy profiles were used to investigate systematic changes of amplitude and frequency on roughness indices. Profiles were 1000 mm in length with amplitude ranging from 0-10 mm and frequency ranging from 0-10 Hz. The roughness algorithms used were Root Mean Square (RMS), Energy, Sinuosity, Z2, Mean Absolute Angle (MAA), and Modified Divider a-Value. Roughness indices were visualized as contour plots. Similarities of the shapes and spacing of the contours as well as the magnitude of the roughness indices prompted the pairing of RMS and Energy algorithms, Z2 and MAA …

A Novel Brain Computer Interface Design, Steven Vogan

Senior Honors Theses

A brain computer interface (BCI) is a system which connects neural signals to a computer system. They have been used for controlling systems including robotics, on-screen computer control such as mouse movement, typing, and synthesizing audio signals. Invasive, or implanted, systems are often long-term medical solutions, or used for research where very clear signal is required. Non-invasive systems usually rely on exterior signals gathered through a headset using one or more electrode sensors. These signals are composed of sums of neuron activation potentials from brain activity and can be used to determine particular aspects of brain function. All BCIs rely …

Protein L Functionalized Microparticles For Early Detection Of Surface Markers In Heterogeneous Colorectal Lesions, Saleh Ramezani

Dissertations and Theses (Open Access)

Colorectal cancer (CRC) is the third leading cause of cancer-related deaths among both men and women worldwide, a statistic that can be improved with early detection. Increased understanding of the tumor landscape has identified surface antigens that can be utilized to distinguish normal and cancerous tissue lining the colonic lumen. Use of antibodies conjugated to nano/micromaterials offers a means to detect these antigens, however, the heterogeneous nature of tumors makes it unlikely that antibodies against a single antigen will have sufficient sensitivity and specificity to detect all tumors. A versatile micromaterial able to be functionalized with more than one targeting …

Photodynamic Therapy To Treat Triple Negative Breast Cancer In Vitro, Hunter S. Warren

All Theses

Triple negative breast cancer (TNBC) is the most resilient form of breast cancer, being one of the leading causes of death for women and making up 7% of all cancer deaths. Photodynamic therapy (PDT) offers a minimally invasive solution to TNBC as a passive-targeting treatment that reduces the need for other well established yet harsh treatments that can be taxing on the patient. PDT involves the use of a high-energy red light on the area of a tumor injected with photosensitizers (PS) that generate reactive oxygen species (ROS) in the tumor, triggering cell death. The PS tetra(hydroxyphenyl)chlorin (m-THPC) was used …

A Hybrid Lateral Flow Sand Filter Wastewater Treatment System: An Evaluation On The Treatment And Disposal Capabilities Of A Modified Sand Filter, Harry Mccaskill Iv

Graduate Theses and Dissertations (2019 - present)

Decentralized wastewater treatment exists primarily in suburban and rural areas where centralized treatment is not an option. Traditional on-site treatment systems usually include the use of a septic tank and a drain field. This orthodox method works well when implemented into environments that are accommodating for the infiltration of effluents, and thus allowing for soil treatment. Unfortunately, there are some circumstances that prevent traditional systems from working such as impermeable soil conditions. The Wastewater Treatment System analyzed in this thesis was created to overcome such inhospitable environments. More specifically, this system is catered towards the rural residences of The Alabama …

Next-Generation Nanopore Sensors Based On Conductive Pulse Sensing For Enhanced Detection Of Nanoparticles, Samuel Confederat, Seungheon Lee, Derr Vang, Dimitrios Soulias, Fabio Marcuccio, Timotheus I. Peace, Martin Andrew Edwards, Pietro Strobbia, Devleena Samanta, Christoph Wälti, Paolo Actis

Chemistry & Biochemistry Faculty Publications and Presentations

Nanopore sensing has been successfully used to characterize biological molecules with single-molecule resolution based on the resistive pulse sensing approach. However, its use in nanoparticle characterization has been constrained by the need to tailor the nanopore aperture size to the size of the analyte, precluding the analysis of heterogeneous samples. Additionally, nanopore sensors often require the use of high salt concentrations to improve the signal-to-noise ratio, which further limits their ability to study a wide range of nanoparticles that are unstable at high ionic strength. Here, a new paradigm in nanopore research that takes advantage of a polymer electrolyte system …

Predicting Dynamic Fragmentation Characteristics From High-Impact Energy Events Utilizing Terrestrial Static Arena Test Data And Machine Learning, Katharine Larsen, Riccardo Bevilacqua, Omkar S. Mulekar, Elisabetta L. Jerome, Thomas J. Hatch-Aguilar

Student Works

To continue space operations with the increasing space debris, accurate characterization of fragment fly-out properties from hypervelocity impacts is essential. However, with limited realistic experimentation and the need for data, available static arena test data, collected utilizing a novel stereoscopic imaging technique, is the primary dataset for this paper. This research leverages machine learning methodologies to predict fragmentation characteristics using combined data from this imaging technique and simulations, produced considering dynamic impact conditions. Gaussian mixture models (GMMs), fit via expectation maximization (EM), are used to model fragment track intersections on a defined surface of intersection. After modeling the fragment distributions, …

Subject-Specific Human Knee Fea Models For Transtibial Amputees Vs Control Tibial Cartilage Pressure In Gait, Cycling And Elliptical Training, Ali Yazdkhasti

Master's Theses

Millions of individuals around the globe are impacted by osteoarthritis, which is the prevailing type of arthritis. This condition arises as a result of gradual deterioration of the protective cartilage that safeguards the ends of the bones. This is especially true of transtibial amputees, who have a significantly higher incidence of osteoarthritis of the knee in their intact limb than non-amputees. Engaging in regular physical activity, managing weight effectively, and undergoing specific treatments can potentially slow down the advancement of the disease and enhance pain relief and joint function. Nevertheless, the relationship between the type of exercise and its impact …

Comparing The Effectiveness Of Different Boosting Algorithms For Ground Water Quality In Telangana Region, Divy Jot

Electronic Theses, Projects, and Dissertations

This culminating experience research project explores the parameters needed to predict the water quality levels for use in different climatic conditions pre and post monsoon from 2018 to 2020 in Telangana State, India. A study was conducted on the water quality analysis by using linear regression with water quality Index in Telangana region. However, in this study we are replicating the water quality analysis by using stack model and machine learning algorithms such as Light Gradient Boosting Machine, Random Forest and Artificial Neural Network. The research Questions are: (Q1) What are the sources of the significant parameters that impact groundwater …

Protein A And Multimodal Anion-Exchange Membrane Adsorbers For Downstream Purification Of Therapeutic Biomolecules, Joshua Osuofa

All Dissertations

This dissertation explores development and characterization of membrane chromatography tools for downstream purification of therapeutic biomolecules. Convective technologies, particularly membrane chromatography, are emerging in the field of bioseparations as an alternative to resin chromatography due to their improved throughput capability. On the forefront of emerging membrane technologies are multimodal and Protein A membrane adsorbers. The overarching theme of this dissertation research was to investigate advances in these membrane chromatography tools. The primary objective was to develop and characterize novel Protein A membrane adsorbers. A secondary objective was to characterize newly commercialized Protein A and multimodal anion exchange membrane adsorbers.

Two …

Improving Lignin Recovery From Paper Mill And Biorefinery Waste Streams Via Liquid-Phase Splitting, Carter Fitzgerald

All Dissertations

Lignin is an abundant biopolymer with significant promise due to its aromaticity. It has been targeted as a replacement for a number of petroleum-based products including adhesives, coatings, polyurethane foams, activated carbon, and carbon fibers. However, commercially available bulk lignins are too polydisperse, and contain too many residual metals from the pulping process that are detrimental to the properties of the final product.

The Sequential Liquid-lignin Recovery and Purification (SLRP) process was developed by Michael Lake and John Blackburn, in collaboration with Clemson, with the intention of creating a continuous method for recovering lignin from paper-mill black liquors. Thies and …

Examining The Influence Of The Classroom Environment On Motivation, Belonging, And Academic Confidence In Engineering Education: A Relational Developmental Systems Approach, Robert O'Hara

All Dissertations

This dissertation explores the impact of the classroom environment on undergraduate engineering students by integrating three manuscripts using the process-person-context-time (PPCT) model within Bioecological Systems Theory. Each manuscript focused on students’ sense of belonging, motivation, and academic confidence. The study confirms prior research suggesting a link between students' perceptions of the environment and their sense of belonging, motivation, and academic confidence. The findings highlight the complex nature of student and classroom environment relationships throughout their college experience. Moreover, the results are demonstrated across different engineering majors. Overall, this dissertation highlights the significance of understanding the complex interactions between students and …