Digital Commons Network^™

Sustainable Sensing With Paper Microfluidics: Applications In Health, Environment, And Food Safety, Sanjay Kumar, Jyoti B. Kaushal, Heow Pueh Lee

Durham School of Architectural Engineering and Construction: Faculty Publications

This manuscript offers a concise overview of paper microfluidics, emphasizing its sustainable sensing applications in healthcare, environmental monitoring, and food safety. Researchers have developed innovative sensing platforms for detecting pathogens, pollutants, and contaminants by leveraging the paper’s unique properties, such as biodegradability and affordability. These portable, low-cost sensors facilitate rapid diagnostics and on-site analysis, making them invaluable tools for resource-limited settings. This review discusses the fabrication techniques, principles, and applications of paper microfluidics, showcasing its potential to address pressing challenges and enhance human health and environmental sustainability.

Implications Of The Covid-19 Pandemic On The Management Of Municipal Solid Waste And Medical Waste: A Comparative Review Of Selected Countries, Ahmed Osama Daoud Dr., Hoda Elattar Eng., Gaber Abdelatif Eng., Karim M. Morsy, Robert W. Peters, Mohamed K. Mostafa Dr.

Civil Engineering

No abstract provided.

Back To The Future: A Case For The Resurgence Of Approximation Theory For Enabling Data Driven “Intelligence”, Michael Dominic Ciocco

Theses and Dissertations

Artificial Intelligence (AI) has exploded into mainstream consciousness with commercial investments exceeding $90 billion in the last year alone. Inasmuch as consumer-facing applications such ChatGPT offer astounding access to algorithms that were hitherto restricted to academic research labs, public focus of attention on AI has created an avalanche of misinformation. The nexus of investor-driven hype, “surprising” inaccuracies in the answers provided by AI models – now anthropomorphically labeled as “hallucinations”, and impending legislation by well-meaning and concerned governments has resulted in a crisis of confidence in the science of AI. The primary driver for AI’s recent growth is the convergence …

Effects Of An Indole Derivative On Cell Proliferation, Transfection, And Alternative Splicing In Production Of Lentiviral Vectors By Transient Co-Transfection, Nataly Carolina Mier, Donald Keith Roper

Biological Engineering Faculty Publications

Lentiviral vectors derived from human immunodeficiency virus type I are widely used to deliver functional gene copies to mammalian cells for research and gene therapies. Post-transcriptional splicing of lentiviral vector transgene in transduced host and transfected producer cells presents barriers to widespread application of lentiviral vector-based therapies. The present study examined effects of indole derivative compound IDC16 on splicing of lentiviral vector transcripts in producer cells and corresponding yield of infectious lentiviral vectors. Indole IDC16 was shown previously to modify alternative splicing in human immunodeficiency virus type I. Human embryonic kidney 293T cells were transiently transfected by 3^rd generation …

Embracing The Irreplaceable: The Role Of Neurodiversity In Cultivating Human-Ai Symbiosis In Education, Piper Hutson

International Journal of Emerging and Disruptive Innovation in Education : VISIONARIUM

This study investigates the indispensable role of human skills—such as empathy, ethical judgment, and nuanced understanding—in the development and application of artificial intelligence (AI) within higher education, highlighting the unique contributions of neurodivergent perspectives in creating a symbiotic human-AI relationship. Drawing upon research that evidences the superior performance of diverse teams in creativity and innovation, the paper argues for the integration of neurodiversity into AI development as a means to address the philosophy of 'fearing the Other,' thereby mitigating biases and fostering ethical AI interactions. The technology sector's adoption of Diversity, Equity, and Inclusion (DEI) programs, including biopsychosocial interventions and …

Single-Molecule Orientation Imaging Reveals The Nano-Architecture Of Amyloid Fibrils Undergoing Growth And Decay, Brian Sun, Tianben Ding, Weiyan Zhou, Tara S. Porter, Matthew D. Lew

Electrical & Systems Engineering Publications and Presentations

Amyloid-beta (Aβ42) aggregates are characteristic Alzheimer’s disease signatures, but probing how their nanoscale architectures influence their growth and decay remains challenging using current technologies. Here, we apply time-lapse single-molecule orientation-localization microscopy (SMOLM) to measure the orientations and rotational “wobble” of Nile blue (NB) molecules transiently binding to Aβ42 fibrils. We correlate fibril architectures measured by SMOLM with their growth and decay over the course of 5 to 20 min visualized by single-molecule localization microscopy (SMLM). We discover that stable Aβ42 fibrils tend to be well-ordered and signified by well-aligned NB orientations and small wobble. SMOLM also shows that increasing order …

06.03.2024 Orsp Connect, Liz Williamson

ORED Newsletter

Center for Population Studies, NSF Postdoc Berg, Quinn Appointed to HEPAP, Smitherman migraine research

A Study On The Effects Of Cementless Total Knee Arthroplasty Implants’ Surface Morphology Via Finite Element Analysis, Scott Hazelwood, Peter J. Hunt, Mohammad Noori, Naudereh B. Noori, Wael A. Altabey

Biomedical Engineering

Total knee arthroplasty (TKA) is one of the most commonly performed orthopedic surgeries, with nearly one million performed in 2020 in the United States alone. Changing patient demographics, predominately indicated by increases in younger, more active, and more obese patients undergoing TKA, poses a challenge to orthopedic surgeons as these factors present a greater risk of long-term complications. Historically, cemented TKA has been the gold standard for fixation, but long-term aseptic loosening continues to be a risk for cemented implants. Cementless TKA, which relies on the surface morphology of a porous coating for biologic fixation of implant to bone, may …

Noninvasive Technique For Measuring Cardiac Output, Grace E. Kolar, Rachel Simonton, Eli Strohecker

Williams Honors College, Honors Research Projects

NA

Tracking Mining Company Electric Vehicles For Sustainable Development Optimization Using Distributed Ledger Technologies, Teodora Hristova

Journal of Sustainable Mining

It is established that based on the industrial revolutions towards Industry 5.0, the population of the Earth and its well-being are increasing. To preserve and improve living conditions the development in all spheres of life is by the paradigm of sustainable development. Through the prism of the mining industry, one step could be the introduction of circular economy measures for digitized tracking of materials, repairs, consumed electricity, safety, and finances. Implementing of electric cars is an option to achieve this goal through automation, manageability, and data traceability via Industry 4.0 technologies. Such are blockchain technologies, IoT, V2V, and others. For …

Engineering An Injectable Hydrogel With Self-Assembling 3d Vasculature, Kendyl Cohn

Master's Theses

This research developed methods for culturing self-assembling capillaries in an injectable gel as a potential method for vascularizing tissue-on-a-chip models to mimic physiological drug delivery. Additionally, a mathematical model was developed as a tool for understanding nutrient delivery and comparison of potential delivery systems. Organs-on-a-chip provide novel platforms for studying biology and physiology in 3D, allow exploration of tissue engineering on a manageable scale, and serve as models for drug screening and drug-delivery testing.

Methods were first developed for co-culture of endothelial cells and fibroblasts (3T3s or HDFs) in 2D, evaluating culture time, seeding density and ratio of HUVECs and …

In-Vitro Hydrogel Blood Clots, Ethan Evans, Khoi-Austin Ngo

Bioengineering Senior Theses

Creating a sustainable, ethical, and affordable substitute for animal blood in balloon catheter testing for Deep Vein Thrombosis (DVT) is important to take into consideration. This research utilizes agarose and dextran to develop hydrogel-based artificial blood clots. These hydro gels replicate the mechanical characteristics of human thrombi across acute, subacute, and chronic stages through their elastic and viscous moduli (G' and G") and phase angles. This project addresses extant testing protocols, including temperature regulation, agarose processing, and well plate size, and suggests efficient approaches to encounter these problems.

The hydrogels were characterized by means of a thorough literature review and …

Packed-Bed Reactor For Integrated Peritoneal Dialysis, Julia Appleget, Ally Kwong, Megan Moglia

Bioengineering Senior Theses

Patients with chronic kidney disease (CKD) have lost kidney function. 800,000 Americans have end-stage kidney disease resulting in one of the leading causes of mortality cross-listed with diabetes and heart disease. Over the past decade, the percentage of patients using peritoneal dialysis (PD) has nearly doubled. PD which is a portable treatment involves the insertion of a catheter into the selectively permeable peritoneal cavity infused with a hyperosmolar dialysis fluid drawing the toxins from capillary beds of the peritoneum and into a gravity fed waste solution with a reported clearance of 87%. In order to improve the clearance of the …

In The Lab - Part 1, Ashley S. Mcguire

Patent Coloring Books

Patent coloring book

Technocene, Vir Joseph Naidu

Masters Theses

Embodied human communication within the Anthropocene. Existing at the intersection of technology, and the body.

The design industry has developed technology that is, paradoxically, isolating. The exposure to a vast audience in the digital sphere has introduced new societal pressures, leading to a disconnection from our immediate surroundings, detached, and donning metaphorical masks. Technocene lives on the fringes of the discipline by blending conceptual thinking with practical application. Through curious, experimental artifacts, it prompts us to shed our masks and embrace vulnerability. Technocene endeavors to reimagine the human experience by acting as a discursive design project. It probes the boundaries …

Using Dft On Ultrasound Measurements To Determine Patient-Specific Blood Flow Boundary Conditions For Computational Hemodynamics Of Intracranial Aneurysms, Hang Yi, Zifeng Yang, Luke Bramlage, Bryan Ludwig

Mechanical and Materials Engineering Faculty Publications

Boundary conditions (BCs) is one pivotal factor influencing the accuracy of hemodynamic predictions on intracranial aneurysms (IAs) using computational fluid dynamics (CFD) modeling. Unfortunately, a standard procedure to secure accurate BCs for hemodynamic modeling does not exist. To bridge such a knowledge gap, two representative patient-specific IA models (Case-I and Case-II) were reconstructed and their blood flow velocity waveforms in the internal carotid artery (ICA) were measured by ultrasonic techniques and modeled by discrete Fourier transform (DFT). Then, numerical investigations were conducted to explore the appropriate number of samples (N) for DFT modeling to secure the accurate BC by comparing …

Advances In Bone And Orthopedics 2024 Edition, Jean-Philippe Berteau, Laurent Pujo-Menjouet

Publications and Research

We are delighted to present the latest edition of ”Advances in Bone and Orthopedics,” a comprehensive compilation of pioneering research and innovative developments in the field. This volume brings together a selection of peer-reviewed abstracts from BONITOS 2024, the Fourth Season of the Bone and Orthopedics Interdisciplinary Symposium, held on May 31st, 2024, at the College of Staten Island in New York. This symposium, a hallmark event in the calendar of professionals dedicated to bone health and orthopedic excellence. The contributions within this volume reflect the breadth and depth of research presented at BONITOS 2024. These abstracts represent cutting-edge studies …

Prescribed-Time Nash Equilibrium Seeking For Pursuit-Evasion Game, Lei Xue, Jianfeng Ye, Yongbao Wu, Jian Liu, D. C. Wunsch

Electrical and Computer Engineering Faculty Research & Creative Works

Dear Editor, this letter is concerned with prescribed-time Nash equilibrium (PTNE) seeking problem in a pursuit-evasion game (PEG) involving agents with second-order dynamics. In order to achieve the prior given and user-defined convergence time for the PEG, a PTNE seeking algorithm has been developed to facilitate collaboration among multiple pursuers for capturing the evader without the need for any global information. Then, it is theoretically proved that the prescribed-time convergence of the designed algorithm for achieving Nash equilibrium of PEG. Eventually, the effectiveness of the PTNE method was validated by numerical simulation results.

The Effect Of Watts-Strogatz And Barabási-Albert Graphs On Memory Formation, Ethan Irick Wolfe

Master's Theses

Understanding higher level cognitive processes is a central problem in neuroscience. The Neuroidal model provides a useful framework for posing these problems in a computer science context. There has been significant recent work trying to understand memory capacity in the Neuroidal model but this work was done assuming that the network of neurons was an Erdos-Renyi random graph. However the network of neurons in the brain has been shown to exhibit small-world properties, which are not present in Erdos-Renyi graphs. In this research we explore replacing Erdos-Renyi graphs with Watts-Strogatz and Barabasi-Albert graphs in order to more accurately model the …

Improving Aerospace System Robustness Integration Of Singular Value Decomposition And Network Centrality, Ricardo S. Contreras

Master's Theses

This thesis presents an approach to understanding and enhancing the robustness of aerospace systems through the integration of network analysis, Design Structure Matrix (DSM), Singular Value Decomposition (SVD), and robustness simulation techniques. This methodology called the Importance Hierarchy method, provides a comprehensive framework for decomposing the interactions of aerospace systems, focusing on identifying and evaluating critical components and interactions.

The Importance Hierarchy method was used to study the Autonomous Flight Termination Unit (AFTU) by analyzing its components and interdependencies. The AFTU was selected because it recently completed a Preliminary Design Review (PDR), and its design and operational functions were well-known. …

Usability Analysis Of The Ronnie Baugh (Oggun Ii) Tractor Using The Single Usability Metric [Research Note], John Lester Remot, John Kenneth Punongbayan, Stephanie Caridad Landicho, Alan Marco Mercado, Josefa Angelie Revilla, Omar Zubia

The Philippine Agricultural Scientist

Agricultural mechanization is one of the policies created by the Philippine government to alleviate systemic problems facing the country. In 2020, a local company was licensed to manufacture the American-designed Ronnie Baugh tractor (RBT), which aims to enable smaller-scale production with low-cost and customizable features. This study assessed the usability of the RBT and evaluated the appropriateness of its design for Filipino tractor operators using the single usability metric (SUM). A total of 21 participants were classified according to their age and experience (A – young and experienced, B – old and experienced, and C – young and inexperienced) and …

Prosthetic Forearm Controller, Claire Tylutki, Kevin Lopatka, Sofia Zaletel, Hardit Singh

Electrical Engineering

The EMG controlled prosthetic arm project represents a significant advancement in upper limb prosthetics, leveraging cutting-edge technology to address critical user needs. With over two million individuals in the United States living with limb loss, a substantial portion being upper limb amputees, the demand for accessible and functional prosthetic solutions is pressing. This project focuses largely on refining prosthetic limb control through the integration of electromyography (EMG) signal processing and control. Using surface electrodes, this project employs non-invasive means of data collection combined with modern digital signal processing methods to implement faster and more accurate control. The control system also …

Unconventional Computing With Photonic Oscillator Networks, Mostafa Honari Latifpour

Dissertations, Theses, and Capstone Projects

The ever-increasing demand for data processing and the challenges in scaling traditional computing architectures are driving intensive research into alternative computing paradigms. Optical computing has garnered renewed attention since the 2010s, driven by its potential to accelerate specialized computational tasks such as combinatorial optimization and neural networks.

Coherent light sources including lasers and parametric oscillators have been around for decades and become indispensable tools in modern technology, but these photonic oscillators are also nonlinear dynamical systems that can exhibit emergent, complex phenomena, especially when coupled in arrays. These nonlinear optical systems have recently been shown to be capable of doing …

Poster: Towards Efficient Spatio-Temporal Video Grounding In Pervasive Mobile Devices, Dulanga Kaveesha Weerakoon Mudiyanselage, Vigneshwaran Subbaraju, Joo Hwee Lim, Archan Misra

Research Collection School Of Computing and Information Systems

As the use of pervasive devices expands into complex collaborative tasks such as cognitive assistants and interactive AR/VR companions, they are equipped with a myriad of sensors facilitating natural interactions, such as voice commands. Spatio-Temporal Video Grounding (STVG), the task of identifying the target object in the field-of-view referred to in a language instruction, is a key capability needed for such systems. However, current STVG models tend to be resource-intensive, relying on multiple cross-attentional transformers applied to each video frame. This results in runtime complexity that increases linearly with video length. Furthermore, deploying these models on mobile devices while maintaining …

Echoes Of Nature: Using Biodata Sonification To Model Electrical Communication In Plants, Penelope Anna Alioshin

Electrical Engineering

The use of biodata sonification as a tool to visualize biological data is a response to recent developments in the intersection of art and technology. This project explores the intersection by converting the electrical impulses given off by plants into audio signals. By processing and amplifying the voltage difference between two electrodes on a plant, its communication is quantified. The goal is to use this communication model as a tool to increase ecological awareness as well as improve machine learning models. A deeper understanding of non-human communication systems, specifically those that employ superposition decision matrices, could help to drastically increase …

Autonomous Hydroponic System, Bella Wanebo, Ashley Oh, Jason Slifka

Mechanical Engineering Senior Theses

Hydroponics is a potentially useful farming technique for growing food in climates where it is difficult to naturally farm. However, hydroponic systems in harsh climates are usually very large and unable to be easily moved around. The design of a portable, enclosed hydroponic garden using the soilless Nutrient Film Technique (NFT) with a vertical configuration that can grow spinach in Antarctica will be discussed. It will have a reversible flow to evenly distribute nutrients to stacked rows of plants. A tradeoff analysis shows that 3D printing a custom T splitter is the best option for controlling the flow within the …

The Synthesis, Characterization, And Application Of Polysaccharide-Based Additive To Improve Wet And Dry Strength And High-Barrier Properties Of Paper Products, Cornellius Marcello

Dissertations

Paper products play an essential role in our daily lives owing to their low cost, environment-friendly character, renewability, and recyclability. Paper manufacturers have been using petroleum-based strength additives (cPAM, GPAM, PAE) to meet the perceived needs of customers. On the other hand, paper produced from cellulose is hydrophilic and porous, leading to shallow water and grease resistance, causing paper manufacturers to use many kinds of coating materials such as poly-fluoroalkyl substances (PFAS) and synthetic plastic to improve water resistance, especially for food packaging paper products like cups, plates, food boxes, and packaging. However, PFAS are identified as likely carcinogenic to …

Scaffold-Free Development Of Multicellular Tumor Spheroids With Spatial Characterization Of Structure And Metabolic Radial Profiles, Shelby N. Bess, Gaven K. Smart, Matthew J. Igoe, Timothy J. Muldoon

Biomedical Engineering Faculty Publications and Presentations

Purpose

In vitro assays are essential for studying cellular biology, but traditional monolayer cultures fail to replicate the complex three-dimensional (3D) interactions of cells in living organisms. 3D culture systems offer a more accurate reflection of the cellular microenvironment. However, 3D cultures require robust and unique methods of characterization.

Methods

The goal of this study was to create a 3D spheroid model using cancer cells and macrophages, and to demonstrate a custom image analysis program to assess structural and metabolic changes across spheroid microregions.

Results

Structural characterization shows that cells at the necrotic core show high normalized fluorescence intensities of …

Development Of A Two-Photon Imaging System, Jesseca Hollenbaugh

University Honors Theses

The objective of this project was to convert a Sarastro 2000 confocal laser scanning microscope (CLSM) into a system capable of far-field two-photon excitation (TPE) imaging for the use of the PSU Biology department. TPE microscopy operates on the ability of fluorophores to accept two photons each with half the energy of a desired transition in a single quantum event via a virtual energy state and then emit a higher energy photon upon relaxation. This is preferable to single-photon excitation (SPE) imaging due to lower photon imaging, causing less damage to delicate biological samples, as well as the inherent localization …

Acoustic Activation Imaging With Intravenous Perfluoropropane Nanodroplets Results In Selective Bioactivation Of The Risk Area, S. Li, C. Chen, J. Lof, E. A. Stolze, J. Sklenar, X. Chen, J. J. Pacella, F. S. Villanueva, T. O. Matsunaga, E. Carr Everbach, S. J. Radio, S. N. Westphal, S. Shiva, F. Xie, X. Leng, T. R. Porter

Engineering Faculty Works

Background: Acoustically activatable perfluoropropane droplets (PD) can be formulated from commercially available microbubble preparations. Diagnostic transthoracic ultrasound frequencies have resulted in acoustic activation (AA) predominately within myocardial infarct zones (IZ). Objective: We hypothesized that the AA area following acute coronary ischemia/reperfusion (I/R) would selectively enhance the developing scar zone, and target bioeffects specifically to this region. Methods: We administered intravenous PD in 36 rats and 20 pigs at various stages of myocardial scar formation (30 minutes, 1 day, and 7 days post I/R) to determine what effect infarct age had on the AA within the IZ. This was correlated with …