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Collision Dynamics Of Compound Droplets In Microchannels: A Combined Numerical And Data-Driven Study, S M Abdullah Al Mamun Aug 2024

Collision Dynamics Of Compound Droplets In Microchannels: A Combined Numerical And Data-Driven Study, S M Abdullah Al Mamun

Dissertations

Understanding and predicting the hydrodynamic interactions of micron-scale droplets is crucial in a wide range of industrial and real-life applications, including microfluidics, pharmaceutics, drug delivery, food science, and enhanced oil recovery. These multi-phase and multi-scale phenomena are further complicated by the presence of core droplets of an immiscible fluid within shell droplets, known as compound droplets. The collisions and interactions of droplets in emulsions are influenced by various physical and geometric parameters, leading to distinct rheological and dynamic responses. This research employs numerical methods for a systematic parametric study of both simple and compound droplet pair collisions under confined shear …


Faculty Perspectives On Research Mentoring Across A Multi-Level Statewide Lsamp Alliance, Tokesha Warner, Shaniqua Nixon, Terrance Mcneil, Denise Green, John T. Robinson Aug 2024

Faculty Perspectives On Research Mentoring Across A Multi-Level Statewide Lsamp Alliance, Tokesha Warner, Shaniqua Nixon, Terrance Mcneil, Denise Green, John T. Robinson

The Journal of the Research Association of Minority Professors

In this, mixed-method exploratory sequential design study, we examined a multi-level state-wide mentoring program for underrepresented students in science, technology, engineering, and mathematics (STEM). This study examined faculty perspectives on the factors involved in, and the impact of, mentoring minoritized students at the critical retention-to-graduation stage. Between 2020 and 2022, an online survey and two rounds of focus group interviews were conducted with faculty members at participating institutions. Data were analyzed using an iterative, thematic coding method. Analysis of the comments from faculty focus groups and a faculty survey revealed eleven themes that codified the faculty member’s perspectives on mentoring. …


Investigation On Production, Kinetic Modelling, Downstream Processing, And Characterization Of Microbial Dextran Using Sucrose-Rich Alternate Feedstocks, Sameeha Syed Ar Aug 2024

Investigation On Production, Kinetic Modelling, Downstream Processing, And Characterization Of Microbial Dextran Using Sucrose-Rich Alternate Feedstocks, Sameeha Syed Ar

Theses and Dissertations

Microbial exopolysaccharides (EPS) synthesized by microorganisms have a wide range of applications from thickener agents in the field of food to formulations in the field of pharmaceuticals. Owing to their rheological, structural, and physicochemical characteristics in addition to its biodegradability, low antigenicity, antioxidant activities, etc., several EPS have gained research focus in recent years. Dextran is one such example of EPS, which is synthesized by lactic acid bacteria (LAB). However, its production is limited to utilization of sucrose medium with a yield of 0.3-0.4 g dextran/ g sucrose. Hence, this thesis work focuses on dextran production using sucrose-rich alternate feedstocks …


Sustainable Valorization Of Woody And Herbaceous Biomass For Energy And Environmental Applications, Subramaniyasharma S Aug 2024

Sustainable Valorization Of Woody And Herbaceous Biomass For Energy And Environmental Applications, Subramaniyasharma S

Theses and Dissertations

Pyrolysis is a thermochemical conversion method to produce gas and liquid fuels from lignocellulosic biomass. This process involves the thermal decomposition of organic compounds without oxygen. The vapors formed are rapidly condensed to yield a liquid product called bio-oil and a solid product called biochar.

In the present study, Sesame indicum (SI) (herbaceous agro residue) and Prosopis julifora (PJ) (woody biomass weed) were chosen as feedstocks for the pyrolysis process and the respective solid and liquid products were collected and characterized. The proportion of biomass pyrolysis products is significantly influenced by biomass composition and process conditions such as temperature, heating …


Development Of Electrochemical Sensors For The Detection Of Pesticide Residues In Water, Indhu S Aug 2024

Development Of Electrochemical Sensors For The Detection Of Pesticide Residues In Water, Indhu S

Theses and Dissertations

Intentional and unintentional events of pesticide poisoning and their accidental exposure have significantly raised the concerns of global organizations to classify these chemical compounds based on their toxicity, to assign permissible limits, and to appoint task force for periodic monitoring of their presence in water bodies.

In this context, researchers are continually seeking potential alternatives to develop water quality sensors with higher selectivity to obtain the desired performance during real-time assessment. Electrochemical sensors involving interface materials of distinguishing capacity at elevated matrix complexity are desirable. However, there remains a challenge in designing suitable techniques, methodologies, and appropriate validations to support …


Investigation On Strength Durability And Crack Healing Efficiency Of Natural Fiber Reinforced Bacterial Concrete Under Various Exposures, Rajesh A Aug 2024

Investigation On Strength Durability And Crack Healing Efficiency Of Natural Fiber Reinforced Bacterial Concrete Under Various Exposures, Rajesh A

Theses and Dissertations

Concrete is the most broadly utilized construction material due to its availability and cost. It is more susceptible to cracks, allowing chemical substances and water to enter and deteriorate the materials over time, as well as affecting the durability properties of structures. In recent years, the use of bacteria and natural fibers in concrete has not only reduced cracks but also enhanced its strength and durability.

Microbial-induced carbonate precipitation (MICP) is highly acceptable in concrete to improve rheological and crack repair properties. In the current research isolated five bacteria from various locations and subjected to basic tests such as urease …


Recent Evolution In Thermochemical Transformation Of Municipal Solid Wastes To Alternate Fuels, Tumpa R. Sarker, Lucky Khatun, Bangladesh Agricultural University, Rostom Ali, Shariful Islam, Sagor Chowdhury, Kazi Sakibur Rahman, Nafis Sadique Sayem, Akm S. Rahman Aug 2024

Recent Evolution In Thermochemical Transformation Of Municipal Solid Wastes To Alternate Fuels, Tumpa R. Sarker, Lucky Khatun, Bangladesh Agricultural University, Rostom Ali, Shariful Islam, Sagor Chowdhury, Kazi Sakibur Rahman, Nafis Sadique Sayem, Akm S. Rahman

Publications and Research

The management of solid waste poses a worldwide obstacle in the pursuit of a sustainable society. This issue has intensified with the increase in waste production caused by rapid population expansion, industrialization, and urbanization. The continuously growing volume of municipal solid waste, particularly the substantial volume of organic waste, along with improper disposal practices, results in the release of greenhouse gases and other harmful airborne substances which simultaneously causes health risks and socioeconomic concerns. This article examines various waste-to-energy (energy production in the form of heat and electricity) concepts as well as waste-to-materials (various value-added materials including biofuel, biochemical, char, …


Experimental Study Of The Ultrasonic Extraction Process Of Plant Raw Materials, Azamat Bakir Ogli Usenov, Doston Ishmuxammat Ogli Samandarov, Qobil Akmal Ogli Mukhiddinov, Jasur Esirgapovich Safarov Dcs Aug 2024

Experimental Study Of The Ultrasonic Extraction Process Of Plant Raw Materials, Azamat Bakir Ogli Usenov, Doston Ishmuxammat Ogli Samandarov, Qobil Akmal Ogli Mukhiddinov, Jasur Esirgapovich Safarov Dcs

Chemical Technology, Control and Management

In-depth scientific research is being conducted around the world aimed at developing the scientific and methodological foundations of energy-saving extractors, processing medicinal plants, increasing the efficiency of modern technologies, processes and equipment for obtaining high-quality pharmaceutical raw materials rich in biologically active substances. Energy-saving extractors, developed in conjunction with the extraction process of medicinal plants, are introduced into the industry using scientifically proven technology. At the global level, special attention is paid to the creation of intelligent designs of innovative extraction plants that operate using ultrasonic waves, allowing the extraction of medicinal components of plants.


Optimization Of Bioethanol Production Using An Enzymatic Hydrolysis Process With Green Algae (Chaetomorpha) As The Raw Material, Teuku Maimun, Mirna Rahmah Lubis, Muhammad Aldi Zein, Wahed Febbry Andriansyah Ali Aug 2024

Optimization Of Bioethanol Production Using An Enzymatic Hydrolysis Process With Green Algae (Chaetomorpha) As The Raw Material, Teuku Maimun, Mirna Rahmah Lubis, Muhammad Aldi Zein, Wahed Febbry Andriansyah Ali

Makara Journal of Technology

Bioethanol is an alternative fuel derived from biological feedstock used to decrease the reliance on fossil fuels because of increasing energy consumption associated with population growth and increased use of oil fuels. Bioethanol production has been widely conducted using several types of algae, but the optimal conditions for the hydrolysis and fermentation processes are not explained in more detail. Therefore, this study focuses on determining the optimal conditions for hydrolysis and fermentation to maximize the bioethanol yield. This study uses optimization based on the hydrolysis time, temperature, and pH to increase the reducing sugar content using high-performance liquid chromatography in …


In Silico Modelling And Docking Simulation Of Egfr-Targeted Diphtheria Toxin Chimera With Various Targeting Moieties, Muhammad Afif Naufal Bmed, Benedictus Ansell Susanto Bmed, Talitha Dinda Gunawan Bmed, Azhar Ridha Lukman Bmed, Alifa Rahma Rizqina Bmed, Muhammad Misbahul Fuad Bmed Aug 2024

In Silico Modelling And Docking Simulation Of Egfr-Targeted Diphtheria Toxin Chimera With Various Targeting Moieties, Muhammad Afif Naufal Bmed, Benedictus Ansell Susanto Bmed, Talitha Dinda Gunawan Bmed, Azhar Ridha Lukman Bmed, Alifa Rahma Rizqina Bmed, Muhammad Misbahul Fuad Bmed

Indonesian Journal of Medical Chemistry and Bioinformatics

Introduction: Cancer is a major etiology of death worldwide due to high mortality and suboptimal medicine. However, an emerging field, targeted therapy enabled a more selective and effective therapeutic action. This article aims to analyze in-silico the hypothetical targeted therapy agent that is combinations of conjugate consisting of EGFR targeting moieties and diphtheria toxin (DT-390).

Method: Our novel peptide is a conjugate of a novel EGFR targeting peptide and DT-390, forming a chimera. The tertiary structure was predicted using AlphaFold 2.0. The best IDDT scoring and stereochemistry profiles were utilized. The HADDOCK2.4 webserver modelled the docking between our …


A Step By Step Shoreline Attribute Analysis For Selected Waterbodies In The Gulf Of Mexico To Promote The Use Of Living Shorelines, Christoper Boyd, Xutong Niu, Taylor R. Horn Aug 2024

A Step By Step Shoreline Attribute Analysis For Selected Waterbodies In The Gulf Of Mexico To Promote The Use Of Living Shorelines, Christoper Boyd, Xutong Niu, Taylor R. Horn

Journal of Extension

Living Shorelines are being promoted by coastal extension professionals as a more resilient nature-based solution to control shoreline erosion. The Virginia Institute of Marine Sciences Living Shorelines Suitability Model was run in selected waterbodies within the Gulf of Mexico.

The locations of the selected water bodies, coastal data sets used, and shoreline protection recommendations generated by the Model are presented. A step-by-step statistical analysis conducted through ArcGIS Pro from these selected coastal shorelines will illustrate how extension professionals with novice GIS experience can use the model output to promote living shorelines to coastal property owners, city managers, and developers.


The Prospect Of Indonesian Herbal As An Alternative Treatment For Covid-19 Patient: A Literature-Based Study, Hadi Sunaryo, Wahyu Hidayati Aug 2024

The Prospect Of Indonesian Herbal As An Alternative Treatment For Covid-19 Patient: A Literature-Based Study, Hadi Sunaryo, Wahyu Hidayati

Indonesian Journal of Medical Chemistry and Bioinformatics

Coronavirus disease 2019 (COVID-19) is a new disease caused by a novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The disease has several symptoms from mild to severe and could lead to death for comorbidities and the elderly. Therefore, the infections and mortality cases keep growing day by day, moreover many authorities are trying to suppress it by applying several health protocols, including medicines. Several studies were conducted on drug discovery from plants to cure the disease. The article aimed to do a narrative review about the prospect of JAMU becoming an alternative medicine to cure COVID-19 by mapping …


Analysis Of Predicting Co-Authorship Networks Using Support Vector Machine Model, Mohammed Y. Al-Khuzaie, Sajad Ali Zearah, Abbadullah H. Saleh Aug 2024

Analysis Of Predicting Co-Authorship Networks Using Support Vector Machine Model, Mohammed Y. Al-Khuzaie, Sajad Ali Zearah, Abbadullah H. Saleh

AUIQ Technical Engineering Science

The area of computer science is flourishing, as shown by the rising number of academic works published and the rising number of scholars adding to the existing body of knowledge. This has made it difficult to find previously unrecognized links between publications and those studying them. Using machine learning techniques to foresee missing links and unveil hidden connections, complex network-based link prediction has emerged as a helpful resource in addressing this difficulty. This study aims to solve the problem of finding links between authors’ publications by exploring the use of network-based complex link prediction approaches. A large-scale bibliographic database collected …


A Technical Review On Reservoir Sedimentation And Their Mitigation Strategies, Sadique Khan Aug 2024

A Technical Review On Reservoir Sedimentation And Their Mitigation Strategies, Sadique Khan

AUIQ Technical Engineering Science

Sedimentation in reservoirs is a critical concern of the 21st century which has affected the sustainability and functionality of water retaining structures. This technical review paper on reservoir sedimentation provides a comprehensive analysis of their causes, mechanisms, and their mitigation/control techniques. The paper starts with sedimentation in the reservoir at a global scale focusing on natural (Soil Erosion) and anthropogenic (man-made) factors such as deforestation, land clearing for agricultural purposes, and urbanization contributing to sedimentation in the reservoir. The origin of sediment is heavily influenced by topographical features, with origins located far-reach, mid-reach and near the reservoir. The sedimentation …


A Novel Perfused Contusion Spinal Cord Injury Model To Assess Rapid Mechanical Properties Changes After Blood Spinal Cord Barrier Breakdown, Laura De Marchi Aug 2024

A Novel Perfused Contusion Spinal Cord Injury Model To Assess Rapid Mechanical Properties Changes After Blood Spinal Cord Barrier Breakdown, Laura De Marchi

Theses and Dissertations

Blood-spinal cord barrier (BSCB) disruption exacerbates the tissue damage caused by spinal cord injury (SCI), but the mechanisms and dynamics of how the barrier breakdown affects the mechanical properties of the tissue remain unclear. The perfused bovine ex vivo indentation injury model described here represents a new platform to investigate the short-term effects of altered blood flow and vascular permeability following traumatic spinal cord injury. Our results indicate that injured cords exhibit changes to bulk perfusion, as evidenced by laser speckle contrast imaging, in addition to decreased barrier function shortly after injury. Indentation tests that simultaneously simulate a crush injury …


Phosphorene As A Chemical Nanosensor For Volatile Organic Compound Vapours - A Dft Outlook, Saravanan S Aug 2024

Phosphorene As A Chemical Nanosensor For Volatile Organic Compound Vapours - A Dft Outlook, Saravanan S

Theses and Dissertations

Based on the density functional theory framework, the structural stability of phosphorene allotropes and its various nanostructures are ensured. The various allotropes of phosphorene and its nanostructures such as nanosheets, nanoribbon and nanotubes are used as adsorbing materials for various volatile organic compounds (VOCs) such as alcohols, chloroform, amines and aldehydes. The results of adsorption energy are used to confirm physisorption or chemisorption of VOCs on phosphorene. In addition, the charge transfer outcome suggests whether phosphorene is acting as acceptor or donor of electrons upon interaction of target VOCs.

The electronic attributes such as band structure, projected density of states …


Gsp-Ai: An Ai-Powered Platform For Identifying Key Growth Stages And The Vegetative-To-Reproductive Transition In Wheat Using Trilateral Drone Imagery And Meteorological Data, Liyan Shen, Guohui Ding, Robert Jackson, Mujahid Ali, Shuchen Liu, Arthur Mitchell, Yeyin Shi, Xuqi Lu, Jie Dai, Greg Deakin, Katherine Anna Frels, Haiyan Cen, Yufeng Ge, Ji Zhou Aug 2024

Gsp-Ai: An Ai-Powered Platform For Identifying Key Growth Stages And The Vegetative-To-Reproductive Transition In Wheat Using Trilateral Drone Imagery And Meteorological Data, Liyan Shen, Guohui Ding, Robert Jackson, Mujahid Ali, Shuchen Liu, Arthur Mitchell, Yeyin Shi, Xuqi Lu, Jie Dai, Greg Deakin, Katherine Anna Frels, Haiyan Cen, Yufeng Ge, Ji Zhou

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Wheat (Triticum aestivum) is one of the most important staple crops worldwide. To ensure its global supply, the timing and duration of its growth cycle needs to be closely monitored in the field so that necessary crop management activities can be arranged in a timely manner. Also, breeders and plant researchers need to evaluate growth stages (GSs) for tens of thousands of genotypes at the plot level, at different sites and across multiple seasons. These indicate the importance of providing a reliable and scalable toolkit to address the challenge so that the plot-level assessment of GS can be …


Voltammetric Determination Of Hydrogen Peroxide At Decorated Palladium Nanoparticles/Poly 1,5- Diaminonaphthalene Modified Carbon-Paste Electrode, Ziad Khalifa, Mohamed Fathi Abo Oura, Magdi Abdelazzem, Ablah Hathoot Aug 2024

Voltammetric Determination Of Hydrogen Peroxide At Decorated Palladium Nanoparticles/Poly 1,5- Diaminonaphthalene Modified Carbon-Paste Electrode, Ziad Khalifa, Mohamed Fathi Abo Oura, Magdi Abdelazzem, Ablah Hathoot

Chemical Engineering

In this work, palladium nanoparticles (PdNPs)/p1,5-DAN/ carbon paste electrode (CPE) and p1,5-DAN/CPE sensors have been developed for determination of hydrogen peroxide. Both sensors showed a highly sensitive and selective electrochemical behaviour, which were derived from a large specific area of poly 1,5 DAN and super excellent electroconductibility of PdNPs. PdNPs/p1,5-DAN/CPE exhibited excellent performance over p1,5-DAN/CPE. Thus, it was used for detecting hydrogen peroxide (H2O2) with linear ranges of 0.1 to 250 μM and 0.2 to 300 μM as well as detection limits (S/N= 3) of 1.0 and 5.0 nM for square wave voltammetry (SWV) and cyclic voltammetry (C.V) techniques, respectively. …


Control Of A Robotic Leg Based On An Adaptive Optimized Fuzzy Algorithm, Adnan Hussein Hasan, Mohammed Ayad Saad Aug 2024

Control Of A Robotic Leg Based On An Adaptive Optimized Fuzzy Algorithm, Adnan Hussein Hasan, Mohammed Ayad Saad

AUIQ Technical Engineering Science

The goal of our investigation is to create a way of directing a robotic limb that is based on an adaptive optimum fuzzy algorithm, as is clear from the study's title. To create an adaptive fuzzy controller for a robotic limb is the goal of this project. By joining the robotic leg to the human foot, it is possible to increase load-bearing capacity and make up for limitations brought on by injury, ageing, etc. Consider a 3R planar open chain for the leg. Rotating actuators supplied by a fundamental control system are used to regulate the robot joints' motion in …


Video Steganography Based On Sine Chaotic Map And Hamming Code, Marwa M Naji, Ahmad T Abdulsadda, Salim Muhsin Wadi Aug 2024

Video Steganography Based On Sine Chaotic Map And Hamming Code, Marwa M Naji, Ahmad T Abdulsadda, Salim Muhsin Wadi

AUIQ Technical Engineering Science

With the increase in internet usage, data exchange happens at a higher pace, but with this comes the risk of security breaches. Hackers often target data exchange, making security a top priority. To address this issue, steganography has proven to be an effective solution. It involves concealing confidential data behind seemingly innocuous cover files, making it less likely to be detected. In a recent paper, the use of Sine chaotic map was proposed as a way to enhance security. Chaotic maps are sensitive to initial values, non-linear, and non-periodic, making them ideal for encryption. The proposed method involves using a …


Facial Expression Recognition And Classification For Autism Spectrum Disorder Based On Sdft Images Using Deep Learning, Sameer Hameed Abdulshahed, Ahmad Taha Abdulsadda Aug 2024

Facial Expression Recognition And Classification For Autism Spectrum Disorder Based On Sdft Images Using Deep Learning, Sameer Hameed Abdulshahed, Ahmad Taha Abdulsadda

AUIQ Technical Engineering Science

Autism spectrum disorder (ASD) is a prevalent condition in childhood, affecting around 1 in 44 individuals. Approximately 53% of children with ASD exhibit one or more challenging behaviors (CBs), which include aggression, self-injury, property destruction, elopement, and more. This percentage is significantly higher compared to their typically developing peers or those with other developmental disorders. Cognitive-behavioral therapy (CB) has numerous detrimental effects on the individual, all of which are linked to an unfavorable long-term result. When it comes to caregivers of children with ASD, the presence of Challenging Behaviors (CB) is a more dependable indicator of stress than the intensity …


Advancing Electrochemical Microsensors For Multiplexed Neurotransmitters And Environmental Toxins Detection, Sanjeev Billa Aug 2024

Advancing Electrochemical Microsensors For Multiplexed Neurotransmitters And Environmental Toxins Detection, Sanjeev Billa

Doctoral Dissertations

Electrochemical sensors have emerged as a promising solution for monitoring neurotransmitters and heavy metals, which could ensure good health and safety in the environment. This dissertation focuses on advancement in the field of electrochemical microsensors by improving the electrode properties and sensor metrics such as rapid response time, multiplexing, high sensitivity, high selectivity, and accuracy for the real-time monitoring of neurotransmitters (glutamate and GABA) and heavy metals (cadmium and lead). In this dissertation, a novel silicon (Si) multifunctional biosensor probe with four platinum ultramicroelectrodes (UMEs) and an on-demand in situ calibration (ODIC) microfluidic channel was optimized for sub-second simultaneous real-time …


Micropatterning Of Biologically Derived Surfaces With Functional Clay Nanotubes, Nisha Lama Aug 2024

Micropatterning Of Biologically Derived Surfaces With Functional Clay Nanotubes, Nisha Lama

Doctoral Dissertations

In this study, we have generalized an assembly of 50 nm diameter clay nanotubes on larger 20-50 μm diameter biological microfibers such as human hair (protein), cotton (cellulose) and synthetic polyethylene terephthalate- PET. We developed a common set of parameters and nanoclay coating techniques on these naturally different microfibers. We exploited and optimized the electrostatic interaction of the components through strategic adjustments in the solvent pH, employing polycation treatment, as well as selectively modifying the halloysite nanotubes with silanes. For 5 mins, a 5 wt% aqueous dispersion of halloysite nanotubes were applied to get approximately 1-2 μm thick fiber coating …


Robotic Odor Source Localization Using Vision And Olfaction Sensing, Sunzid Hassan Aug 2024

Robotic Odor Source Localization Using Vision And Olfaction Sensing, Sunzid Hassan

Master's Theses

Robotic Odor Source Localization (ROSL) technology allows autonomous agents like robots to find an odor source in unknown environments. A successful odor source location depends crucially on an effective navigation algorithm that directs the robot towards the odor source. This thesis is a combination of three projects. First, we detail development of a versatile multi-modal robotic platform for ROSL real-world ROSL experimentation and discussed real-world validation of a traditional olfactionbased ROSL algorithm. Secondly, we introduced vision in ROSL by proposing a fusion navigation algorithm that integrates deep-learning enabled vision and olfaction-based navigation. This hybrid approach tackles challenges such as turbulent …


Optogenetic Control Of Bacterial Dormancy, Yousr Dhaouadi Khattab Aug 2024

Optogenetic Control Of Bacterial Dormancy, Yousr Dhaouadi Khattab

Dissertations - ALL

The presence of persister cells makes it difficult to eradicate chronic bacterial infections as these dormant subpopulations arise with exposure to stressors and are capable of surviving antimicrobials that target active cells. Persisters can also revert back to normal growing cells when stressors are removed thus reestablishing the infection. It is therefore important to understand the underlying mechanisms of persister formation, as well as wake-up, and target these systems in order to treat chronic bacterial infections. The formation of persisters, however, remains elusive as there is not yet a clear relationship between the various stages of dormancy. Persister cells can …


Metabolite Biomarker Discovery For Lung Cancer Using Machine Learning, Ariski Fajarido, Linda Erlina, Aryo Tedjo, Fadilah Fadilah, Wawaimuli Arozal Aug 2024

Metabolite Biomarker Discovery For Lung Cancer Using Machine Learning, Ariski Fajarido, Linda Erlina, Aryo Tedjo, Fadilah Fadilah, Wawaimuli Arozal

Indonesian Journal of Medical Chemistry and Bioinformatics

Lung cancer is the leading cause of cancer death worldwide. About 2.1 million lung cancer patients were diagnosed in 2018, accounting for about 11.6% of all newly diagnosed cancer cases. For lung cancer, blood is the first choice as a source of screening biomarker candidates. Blood biomarkers provide a snapshot of the patient's entire body, including the primary tumor, metastatic disease, immune response, and peritumoral stroma. However, sputum sampling, bronchial lavage or aspiration, exhaled breath (EB), and airway epithelial sampling represent unique samples for lung cancer and other airway cancers as potential sources for alternative biomarkers. Metabolites are products of …


High-Throughput Analysis Of Topographical Cues For The Expansion Of Murine Pluripotent Stem Cells, Abigail Anne Conner, Yuan Yao, Sarah W. Chan, Deepak Jain, Suzanne M. Wong, Evelyn K. Yim, Muhammad Rizwan Aug 2024

High-Throughput Analysis Of Topographical Cues For The Expansion Of Murine Pluripotent Stem Cells, Abigail Anne Conner, Yuan Yao, Sarah W. Chan, Deepak Jain, Suzanne M. Wong, Evelyn K. Yim, Muhammad Rizwan

Michigan Tech Publications

The expansion of pluripotent stem cells (PSCs) in vitro remains a critical barrier to their use in tissue engineering and regenerative medicine. Biochemical methods for PSC expansion are known to produce heterogeneous cell populations with varying states of pluripotency and are cost-intensive, hindering their clinical translation. Engineering biomaterials to physically control PSC fate offers an alternative approach. Surface or substrate topography is a promising design parameter for engineering biomaterials. Topographical cues have been shown to elicit profound effects on stem cell differentiation and proliferation. Previous reports have shown isotropic substrate topographies to be promising in expanding PSCs. However, the optimal …


Consistent Intraocular Pressure Reduction By Solid Drug Nanoparticles In Fixed Combinations For Glaucoma Therapy, Da Huang, Pedro Norat, Lin Qi, Anna Chernatynskaya, James D. Cole, Vimalin Jeyalatha Mani, Lei Xu, Xiaorong Liu, Hu Yang Aug 2024

Consistent Intraocular Pressure Reduction By Solid Drug Nanoparticles In Fixed Combinations For Glaucoma Therapy, Da Huang, Pedro Norat, Lin Qi, Anna Chernatynskaya, James D. Cole, Vimalin Jeyalatha Mani, Lei Xu, Xiaorong Liu, Hu Yang

Chemical and Biochemical Engineering Faculty Research & Creative Works

Efficient topical drug delivery remains a significant challenge in glaucoma management. Although nanoparticle formulations offer considerable promise, their complex preparation processes, co-delivery issues, and batch consistency have hindered their potential. A scalable fabrication strategy is developed here for preparing solid drug nanoparticles (SDNs) with enhanced drug delivery efficiency. Utilizing hydrophobic antiglaucoma drugs brimonidine (BM) and betaxolol (BX), uniform fixed combination BM/BX SDNs are fabricated through a continuous process, improving batch-to-batch consistency for combined glaucoma treatment. With trehalose being used as a lyoprotectant, BM/BX SDNs can be stored as dry powder and easily reconstituted in phosphate buffered saline. Importantly, reconstituted BM/BX …


A Coarse-Grained Molecular Dynamics Study Of Gas Hydrate Formation And Dissociation, Meisam Adibifard Aug 2024

A Coarse-Grained Molecular Dynamics Study Of Gas Hydrate Formation And Dissociation, Meisam Adibifard

LSU Doctoral Dissertations

The study of gas hydrates has increased significantly over the last two decades because of their potential application in energy storage, production and transportation, water desalination, refrigeration, gas separation, etc. There is a significant interest in commercially developing natural gas hydrates because the energy content of methane hydrate reservoirs (MHRs) is at least twice that of all conventional fossil fuels combined. Additionally, due to the higher storage capacity of hydrates, it is proposed to sequester CO2 in the form of CO2 hydrate, thereby reducing the amount of greenhouse gases. Hence, hydrates offer a dual solution to two of …


Investigation Of Heavy Metal Composition And Associated Health Risks From Selected Groundwater Wells In Temeke, Dar-Es-Salaam, Justin M. Jeremiah Aug 2024

Investigation Of Heavy Metal Composition And Associated Health Risks From Selected Groundwater Wells In Temeke, Dar-Es-Salaam, Justin M. Jeremiah

Tanzania Journal of Engineering and Technology (TJET)

Water quality continues to be the challenge to residents in Dar es Salaam due to various anthropogenic activities in the city. This study was conducted to assess groundwater quality by determining concentrations of heavy metals. Both probability and Nonprobability sampling techniques were used to collect samples from 40 groundwater wells in 24 wards of Temeke municipal and analysed using Microwave Plasma Atomic Emission Spectrometer (Agilent 4210 MP-AES) at the Geochemistry Laboratory of the University of Dar es Salaam. Results indicated varying heavy metal concentrations ranging from 0.71 ± 0.08 to 6.64 ± 0.21 mg/l for As, 0.02 ± 0.01 to …