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Thermal Conduction In Molecular Materials Using Coarse Grain Dynamics: Role Of Mass Diffusion And Quantum Corrections For Molecular Dynamics Simulations, Ya Zhou, Alejandro Strachan

PRISM: NNSA Center for Prediction of Reliability, Integrity and Survivability of Microsystems

We use a mesodynamical method, denoted dynamics with implicit degrees of freedom DID, to characterize thermal transport in a model molecular crystal below and above its melting temperature. DID represents groups of atoms molecules in this case using mesoparticles and the thermal role of the intramolecular degrees of freedom DoFs are described implicitly using their specific heat. We focus on the role of these intramolecular DoFs on thermal transport. We find that thermal conductivity is independent of intramolecular specific heat for solid samples and a linear relationship between the two quantities in liquid samples with the coefficient of proportionality being …

Thermal And Mechanical Multistate Folding Of Rnase H, Thomas A. Knotts, Terry J. Schmitt, Jonathan E. Clark

Faculty Publications

Two different classes of experimental techniques exist by which protein folding mechanisms are ascertained. The first class, of which circular dichroism is an example, probes thermally-induced folding. The second class, which includes atomic force microscopy and optical tweezers, measures mechanically-induced folding. In this article, we investigate if proteins fold/unfold via the same mechanisms both thermally and mechanically. We do so using Ribonuclease H, a protein that has been shown to fold through a three-state mechanism using both types of experimental techniques. A detailed, molecular-level description of the states involved in thermal and mechanical folding shows that mechanisms for both types …

Development Of A Methodology For Numerical Simulation Of A D C Arc Discharge In A Liquid Dielectric, Christopher James Lewis

Theses and Dissertations

The majority of literature regarding the numerical simulation of arc discharges in gaseous environments has used a plasma physics approach. Virtually all simulations treat the discharge as an idealized gaseous plasma, which can be described by temperature, pressure, and electric field. This approach can work well if the media is a shielding gas such as Argon; however, the approach does not work well for processes such as underwater welding, EDM, and underwater discharges used to generate high purity particles. The reason these discharges do not have many extensive simulation efforts as described in the literature is because they occur in …

Computational Modeling Of Biochemical Systems Using Cellular Automata, Advait Apte

Theses and Dissertations

Biological systems exhibit complex behaviors through coordinated responses of individual biological components. With the advent of genome-scale techniques, one focus has been to develop methods to model interactions between components to accurately describe intact system function. Mathematical modeling techniques such as constraint-based modeling, agent-based modeling, cellular automata (CA) modeling and differential equation modeling are employed as computational tools to study biological phenomenon. We have shown that cellular automata simulations can be used as a computational tool for 12 predicting the dynamics of biological systems with stochastic behavior. The basic premise for the research was the observations made during a study …

Decision-Based Data Fusion Of Complementary Features For The Early Diagnosis Of Alzheimer's Disease, Metin Ahiskali

Theses and Dissertations

As the average life expectancy increases, particularly in developing countries, the prevalence of Alzheimer's disease (AD), which is the most common form of dementia worldwide, has increased dramatically. As there is no cure to stop or reverse the effects of AD, the early diagnosis and detection is of utmost concern. Recent pharmacological advances have shown the ability to slow the progression of AD; however, the efficacy of these treatments is dependent on the ability to detect the disease at the earliest stage possible. Many patients are limited to small community clinics, by geographic and/or financial constraints. Making diagnosis possible at …

Investigation Of The Mechanical Properties Of Poly (Ethylene Glycol) Diacrylate By Nanoindentation Using Atomic Force Microscopy, Zouheir Drira

Theses and Dissertations

Poly (ethylene glycol) (PEG) hydrogel based polymers are among the most widely used synthetic materials for biomedical applications. Because of their biocompatibility, and ease of fabrication, hydrogels are highly suitable for use as constructs to engineer tissues as well as for cell transplantation. A critical parameter of importance for PEG hydrogels is their mechanical properties which are highly dependent on the environmental conditions. Properties of PEG-based hydrogels can be engineered to resemble scaffolds composed of extracellular matrix molecules, which provide structural support, adhesive sites and mechanical as well as biomechanical signals to most cells. The mechanical properties of these synthetic …

A Physical Model Of Human Skin And Its Application For Search And Rescue, Abel S. Nunez

Theses and Dissertations

For this research we created a human skin reflectance model in the VIS and NIR. We then modeled sensor output for an RGB sensor based on output from the skin reflectance model. The model was also used to create a skin detection algorithm and a skin pigmentation level (skin reflectance at 685nm) estimation algorithm. The average root mean square error across the VIS and NIR between the skin reflectance model and measured data was 2%. The skin reflectance model then allowed us to generate qualitatively accurate responses for an RGB sensor for different biological and lighting conditions. To test the …

Atomic Force Microscopy Of Dna Self-Assembled Nanostructures For Device Applications, Hieu Bui, Craig Onodera, Bernard Yurke, Elton Graugnard, Wan Kuang, Jeunghoon Lee, William B. Knowlton, William L. Hughes

Electrical and Computer Engineering Faculty Publications and Presentations

DNA nanotechnology, which relies on Watson-Crick hybridization, is a versatile selfassembly process whereby a variety of complex nanostructures can be fabricated with sublithographic features.[1] Adopting this technology, 1012 identical devices can be synthesized to have hundreds of components with 1nm resolution. Example nanostructures include: 1) DNA motifs [2], 2) two-dimensional DNA crystals [3], and DNA origami [4]. Currently, this technology is being adopted towards electronic, optical, and opto-electronic devices.[5]

Comparison Of Enhanced-Pso And Classical Optimization Methods: A Case Study For Statcom Placement, Yamille Del Valle, Ronald G. Harley, Ganesh K. Venayagamoorthy

Electrical and Computer Engineering Faculty Research & Creative Works

This paper validates the effectiveness of an enhanced particle swarm optimizer (Enhanced-PSO) method in solving the problem of optimal allocation of FACTS devices in a power system. the performance of the Enhanced-PSO method is compared with classical optimization approaches using a simple but realistic case study of optimal allocation of STATCOM devices, considering steady state and economic criteria. This paper also discusses the concepts and details about the optimization process that tend to be overlooked in the literature since the selection of an optimization algorithm highly depends on them. © 2009 IEEE.

Automatic Exposure Control And Estimation Of Effective System Noise In Diffuse Fluorescence Tomography, Dax L. Kepshire, Hamid Dehghani, Frederic Leblond, Brian W. Pogue

Dartmouth Scholarship

A diffuse fluorescence tomography system, based upon time-correlated single photon counting, is presented with an automated algorithm to allow dynamic range variation through exposure control. This automated exposure control allows the upper and lower detection levels of fluorophore to be extended by an order of magnitude beyond the previously published performance and benefits in a slight decrease in system effective noise. The effective noise level is used as a metric to characterize the system performance, integrating both model-mismatch and calibration bias errors into a single parameter. This effective error is near 7% of the reconstructed fluorescent yield value, when imaging …

Automated Methods For Fiber Diameter Measurement Of Fibrous Scaffolds, Anna Bulysheva

Theses and Dissertations

The purpose of this work was to develop an automated method of measuring fiber diameters of electrospun scaffolds from scanning electron microscopy images of these scaffolds. Several automated methods were developed and evaluated by comparison to known values and data obtained via the standard manual method. Simulated images with known diameters were used as test images to evaluate the accuracy of each measurement technique. Eight scanning electron microscopy images were also used for the evaluation of the automated methods compared to the standard manual method. All diameter measurements were made in pixels. Five new automated methods coded in MATLAB were …

Development Of The Mask Scentometer, A Comparison Of Ambient Odor Assessment Methods, And Their Application In Ground Truthing Atmospheric Dispersion Models, Christopher G. Henry

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

This dissertation is organized as four stand-alone papers. Paper No. 1 describes the development of the Mask Scentometer and reports dilution ratios measured during use by twelve different people. Dilution ratios at the Mask Scentometer’s five dilution-to-threshold (D/T) settings were found to be 0.35, 1, 2, 4.5 and 18. In Paper No.’s 2 and 4, ambient odor assessment methods were compared in both controlled laboratory conditions and in the field. Laboratory analysis of ambient air samples using dynamic triangular forced-choice olfactometry (DTFCO) did not correlate well with any of the ambient odor assessment methods. Average intensity-predicted D/T was roughly five …

Biological Sequence Simulation For Testing Complex Evolutionary Hypotheses: Indel-Seq-Gen Version 2.0, Cory L. Strope

School of Computing: Dissertations, Theses, and Student Research

Reconstructing the evolutionary history of biological sequences will provide a better understanding of mechanisms of sequence divergence and functional evolution. Long-term sequence evolution includes not only substitutions of residues but also more dynamic changes such as insertion, deletion, and long-range rearrangements. Such dynamic changes make reconstructing sequence evolution history difficult and affect the accuracy of molecular evolutionary methods, such as multiple sequence alignments (MSAs) and phylogenetic methods. In order to test the accuracy of these methods, benchmark datasets are required. However, currently available benchmark datasets have limitations in their sizes and evolutionary histories of the included sequences are unknown. These …

Examining Strategic Information Technology In Relationship To The Need For Technology Modernization, Jill A. Brown

Masters Theses & Specialist Projects

Strategic planning can be a critical business process for today’s organizations, especially for IT organizations that are facing continually changes in technology. This research was designed to investigate IT organizations’ use of strategic planning and determine if the organization uses their strategic plan to set project priorities. The second part of this research was to determine if the IT strategic plans are aligned with the overall organization’s strategic plan.

This research was conducted using a mail-type survey to IT Executives from organizations with sales/revenues under 100 million dollars, a maximum of 5000 employees, and SIC codes of 201 thru 399. …

Creating Tomorrow, Fall 2009, College Of Engineering

College of Engineering Magazines

Annual magazine for the College of Engineering at Utah State University.

Thermodynamically Consistent Large Deformation Constitutive Model For Glassy Polymers, Ashwani Kumar Goel

Department of Engineering Mechanics: Dissertations, Theses, and Student Research

Polycarbonate(PC), like most glassy polymers when undergoing large deformations exhibits a very complex thermo-mechanical response. We look at PC as a model glassy polymer and examine its response to changes in loading rate, loading direction and temperature. We show that plastic flow in compression is accompanied by a change in the elastic response of PC from isotropic to anisotropic. This provides the necessity to introduce a new modeling method that can capture these changes. A finite deformation plasticity like thermodynamically consistent model is developed to capture this and the observed rate and temperature dependence. For this modeling method, we need …

Synthesis And Evaluation Of Bioceramics For Orthopedics And Tissue Culture Applications, Hande Demirkiran

Material Science and Engineering Dissertations - Archive

Hydroxyapatite is the most well known phosphate in the biologically active phosphate ceramic family by virtue of its similarity to natural bone mineral. Among all bioglass compositions Bioglass®45S5 is one of the most bioactive glasses. This study initially started by adding different amounts (1, 2.5, 5, 10, and 25 wt. %) of Bioglass®45S5 to synthetic hydroxyapatite in order to improve the bioactivity of these bioceramics.The chemistries formed by sintering and their effect on different material properties including bioactivity were identified by using various techniques, such as powder and thin film x-ray diffraction, scanning electron microscopy coupled with energy dispersive X-ray …

Removal Of Biofilm Through Controlled Cavitation, Mathew Chackalackal Mathew

Master's Theses - Daytona Beach

Human kind is poised to take the next "giant step" in space exploration, the manned mission to Mars, among other things. But before any plans for such long term habitation on an alien planet, there has to be consideration towards prevention and removal of bacterial contamination. Bacterial contamination or rather degradation of materials was considered of negligible importance. Bacterial degradation can be serious for long-term manned space mission, more so because there is no way to obtain quick replacements. For such conditions, a new innovative way of bacterial removal has been proposed wherein the bacteria is removed with no damage …

A Real-Time Implementation Of A Pbil Based Stabilizing Controller For Synchronous Generator, Komla A. Folly, Ganesh K. Venayagamoorthy

Electrical and Computer Engineering Faculty Research & Creative Works

This paper presents the optimal tuning of power system stabilizer parameters using a newly introduced evolutionary algorithm called Population based Incremental Learning (PBIL). to robustly stabilize the system, an objective function that minimizes the infinity norm of the closed-loop system is introduced such that the parameters of a fixed structure PSS are optimally tuned, and the controller stabilizes a pre-specified set of system models. the PBIL-PSS is compared with the Conventional PSS (CPSS). the simulation results presented in this paper show that the proposed PBIL-PSS is more effective than the Conventional PSS in damping the low frequency oscillations. the performance …

Performance Of Storm Water Stage And Quality Measuring Instruemtnation Of A Small Watershed Using A Remote Monitoring Station, Rebecca Crane

All Theses

ABSTRACT


As economic development proceeds special care must be taken to preserve and sustain our water resources. Monitoring the storm water from a watershed during a rainfall event can help quantify any changes in water quantity and quality. An accurate means of measuring flow is necessary for all watershed monitoring projects. This study was conducted to analyze the performance of stage, turbidity, and temperature measuring devices in a laboratory setting as well as on Honeycutt Creek in Clemson, South Carolina.
The stage measuring devices under study include: a radar level sensor, ultrasonic transmitter, pressure transducer, and a bubbler module. A …

The Formation And Control Of Iodinated Trihalomethanes In Drinking Water Treatment, Darryl Jones

All Theses

Ever since toxic disinfection by-products (DBPs) were discovered in the 1970s drinking water utilities have had to continue to develop treatment strategies to reduce the acute health risk from infectious pathogens in water, and at the same time limit the formation of disinfection by-products. The recent two stage (1998, 2006) D/DBP rule enacted by the Environmental Protection Agency (EPA) which sets limits of 80 µg/L for trihalomethanes (THMs) and 60 µg/L for haloacetic acids (HAAs) will likely put more pressure on utilities in the future to decrease their chorine contact time and follow that with ammonia addition to form monochloramine …

A Particle Swarm Optimization Using Random Keys For Flexible Flow Shop Scheduling Problem With Sequence Dependent Setup Times, Vinodh Sankaran

All Theses

In this research, a particle swarm optimization algorithm (PSO) using random keys is developed to schedule flexible flow lines with sequence dependent setup times to minimize makespan. The flexible flow line scheduling problem is a branch of production scheduling and is found in industries such as printed circuit board and automobile manufacturing. It is well known that this problem is NP-hard. For this reason, we approach the problem by implementing a particle swarm optimization (PSO), a metaheuristic which is inspired by the motion of a flock of birds or a school of fish searching for food. The proposed PSO has …

Using Artificial Neural Networks And Model Predictive Control To Optimize Acoustically Assisted Doxorubicin Release From Polymeric Micelles, Ghaleb A. Husseini, Farouq S. Mjalli, William G. Pitt, Nabil M. Abdel-Jabbar

Faculty Publications

We have been developing a drug delivery system that uses Pluronic P105 micelles to sequester a chemotherapeutic drug - namely, Doxorubicin (Dox) - until it reaches the cancer site. Ultrasound is then applied to release the drug directly to the tumor and in the process minimize the adverse side effects of chemotherapy on non-tumor tissues. Here, we present an artificial neural network (ANN) model that attempts to model the dynamic release of Dox from P105 micelles under different ultrasonic power intensities at two frequencies. The developed ANN model is then utilized to optimize the ultrasound application to achieve a target …

Sensor-Based Soil Water Monitoring To More Effectively Manage Agricultural Water Resources In Coastal Plain Soils, Christopher Bellamy

All Theses

Cotton (Gossypium hirsutum L.) is widely grown in the United States with 5.7 million ha grown nationally and 1.2 million ha grown in the humid southeastern states in 2005. From 1969 to 2003, agricultural irrigated farmland acreage and total water applied increased by over 40% and 11% respectively to include a total of 55.3 million acres in 2002. Combined with recent and more frequent drought periods and legal water conflicts between states, there has been an increased interest in more effective southeastern water management, thus making the need to develop improved irrigation scheduling methods and enhanced water use efficiency of …

Spatial Frequency Localization In Mammograms Using Wavelets, Tomislav Bujanovic

Dissertations

Microcalcifications are residual calcium deposits that are often the first signs of developing breast abnormalities that may lead to breast cancer. Up to 30% of cancerous lesion in diagnosed breast cancer cases could have been detected earlier through mammogram screenings if the right tools were available. While the detection of calcifications may be easier in fatty backgrounds, it is challenging in dense parenchyma, suggesting the need for more sensitive tools for accurately identifying suspicious regions in mammograms and propping a computer-aided system for further target classification. Therefore, the objective of the research work in this dissertation is to develop a …

Extraction And Characterization Of Lipids From Microalgae Grown On Municipal Wastewater, Matthew W. Hutton

Master's Theses

Based on results of its Aquatic Species Program (1978-1996), which sought to develop algae-to-liquid fuel technology, the U.S. Department of Energy has suggested that algal wastewater treatment may be incorporated into biodiesel production schemes to reduce the operating costs of both processes. the purpose of the current research was to evaluate the triglycerides produced by wastewater-grown algae for their suitability as a fuel feedstock and to investigate the effectiveness of several solvent mixtures and extraction procedures at recovering lipids from fresh algae. The research involved two separate experiments. The first determined the quantity and quality of lipids produced over the …

Single Cell Impedance Measurements Using Microfabricated Electrodes And Labview Graphical Programming, Stephanie Sophia Hernandez

Master's Theses

This Master’s Thesis project consists of the research, design, and fabrication of a system that could perform broadband impedance measurements (1kHz-20Mhz) of single cells using National Instruments Labview data acquisition and programming in coordination with a single cell capture device. Presented first is the background information on cells and their electrical properties, along with background in micro-total-analysis systems as well as impedance spectroscopy. Experimental Methods are then discussed for the electrode design, cellular modeling in COMSOL, fabrication methods, and Labview 8.0 Set-up and programming. Measurements were performed using the single-cell capture device on saline, yeast cells, and a polysterene bead. …

Me-Em Enewsbrief, December 2009, Department Of Mechanical Engineering-Engineering Mechanics, Michigan Technological University

Department of Mechanical and Aerospace Engineering eNewsBrief

No abstract provided.

Grating Lobe Reduction In Aperiodic Linear Arrays Of Physically Large Antennas, William C. Barott, Paul G. Steffes

Publications

We present performance bounds obtained from the optimization of the sidelobe levels of aperiodic linear arrays. The antennas comprising these arrays are large compared to the distance between neighboring antennas, a case not addressed in previously published work. This optimization is performed in pattern-space and is applicable over a wide range of scan angles. We show that grating lobes can be suppressed even when the elemental antennas are several wavelengths in size, provided that the ratio of the antenna size to the average spacing between the antenna center-points does not exceed 80%.

A Fast Nir Spectrometer For Examining Explosive Events: Emission Of Petn Based Explosives And H2O Absorption Method Feasibility, Scott Piecuch

Master's Theses (2009 -)

The chemical dynamics and decomposition pathways of explosive materials are not entirely known. Measurements of chemical transients during explosive events can lead to enhanced knowledge of the detailed chemistry and eventually control of the end products; however, these measurements are often difficult to obtain due to fast time scales and harsh environments. Optical diagnostics present fast-response, minimally invasive methods for resolving properties in detonation environments and previous fast spectroscopic measurements have been recorded in the ultra-violet and visible regions. This work extends the range of such measurements to the near-infrared (NIR) through the development of a fiber-coupled NIR spectrometer utilizing …