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Department Of Biological Systems Engineering Newsletter, Volume 6, Number 1, January 2010

BSE Department Magazine

No abstract provided.

Toward A Distributed Actuation And Cognition Means For A Miniature Soft Robot, Xiaoting Yang

Electronic Theses and Dissertations

This thesis presents components of an on-going research project aimed towards developing a miniature soft robot for urban search and rescue (USAR). The three significant contributions of the thesis are verifying the water hammer actuation previous work, developing an estimator of water hammer impulse direction from hose shape, and creating the infrastructure for distributed cognitive networks. There are many technical issues in designing soft robots, in terms of perception, actuation, cognition, power, physical structure and so on. We are focusing on actuation and cognition issues in this thesis. We investigated water hammer actuation as an alternative system which provides a …

Electrohydrodynamic Atomization For Improved Macromolecular Drug Delivery, Michelle Zeles-Hahn

Electronic Theses and Dissertations

With advances in drug research, the use of biological therapeutics is becoming a reality. Unfortunately, methods for processing and delivering these fragile macromolecules often limit their therapeutic potential. For this dissertation, we explore the aerosolization of macromolecules by way of electrohydrodynamic atomization (EHDA) and how this method can be used to process and deliver therapeutics. EHDA employs a high voltage to break a column of liquid into drops. It was unknown if or how the residual charge left of the resulting droplets would affect lung cells. An in vitro experiment was conducted to spray aerosolized DNA, by way of EHDA, …

Computational Fluid Dynamic Optimization And Design For The Airborne Laser System, Matthew James Opgenorth

Electronic Theses and Dissertations

The Airborne Laser (ABL) was designed to destroy any ballistic missile shortly after launch that could be a threat to the United States and its allies. The ABL uses several lasers to accomplish the destruction of the ballistic missile, most notably the high powered Chemical Oxygen Iodine Laser (COIL). The COIL is a complex device that could be improved upon in several areas that will result in overall weight reduction, refinement of beam quality, and increased magazine capacity.

This dissertation presents novel design and optimization techniques coupled with fluid dynamics to improve the performance of the COIL system. The focus …

The Role Of Shewanella Oneidensis Mr-1 Outer Surface Structures In Extracellular Electron Transfer, Rachida A. Bouhenni, Gary J. Vora, Justin C. Biffinger, Sheetal Shirodkar, Ken Brockman, Ricky Ray, Peter Wu, Brandy J. Johnson, Eulandria M. Biddle, Matthew J. Marshall, Lisa A. Fitzgerald, Brenda J. Little, Jim K. Fredrickson, Alexander S. Beliaev, Bradley R. Ringeisen, Daad A. Saffarini

United States Navy: Publications

The ability of the metal reducer Shewanella oneidensis MR-1 to generate electricity in microbial fuel cells (MFCs) depends on the activity of a predicted type IV prepilin peptidase; PilD. Analysis of an S. oneidensis MR-1 pilD mutant indicated that it was deficient in pili production (Msh and type IV) and type II secretion (T2S). The requirement for T2S in metal reduction has been previously identified, but the role of pili remains largely unexplored. To define the role of type IV or Msh pili in electron transfer, mutants that lack one or both pilus biogenesis systems were generated and analyzed; …

In-Vivo Testing Of Vertically Aligned Nanowire Implantable Titanium Electrodes In The Rattus Norvegicus Hippocampus, Lauren Kegley

Inquiry: The University of Arkansas Undergraduate Research Journal

Miniaturized multielectrode arrays are MEMS devices that have found use as neural prosthetics (Neuro-MEMS). As implants, they can interface with neurons as sensors or actuators and help compensate for loss of sensory input, motor control, or cognitive functions. The microelectrodes studied here were developed in-house. They have a vertically aligned gold nanowire array and are mounted on a sturdy titanium needle with a fine gauge. Hence, the bill of materials and design characteristics encourage their use as a neural probe. For this study, a probe was tested in vivo for signal acquisition in the hippocampus of a Rattus Norvegicus (Sprague …

Exploration Of The Role Of Serum Factors In Maintaining Bone Mass During Hibernation In Black Bears, Rachel Marie Bradford

Dissertations, Master's Theses and Master's Reports - Open

Disuse osteoporosis is a condition in which reduced mechanical loading (e.g. bed-rest, immobilization, or paralysis) results in unbalanced bone turnover. The American black bear is a unique, naturally occurring model for the prevention of disuse osteoporosis. Bears remain mostly inactive for up to half a year of hibernation annually, yet they do not lose bone mechanical strength or structural properties throughout hibernation. The long-term goal of this study is to determine the biological mechanism through which bears maintain bone during hibernation. This mechanism could pinpoint new signaling pathway targets for the development of drugs for osteoporosis prevention. In this study, …

2009/10 Research, Development, And Activities, College Of Engineering And Applied Sciences

Electrical and Computer Engineering Newsletter

• Design of iPhone Game Applications for the Eyes on the Earth Initiative
• Printed Electronics Research and Sensor Development
• Dual-Use Ground Vehicle Condition-Based Maintenance
• TS-Type Fuzzy Automaton for Software Agents
• NEW DEAN – College of Engineering & Applied Sciences
• Nonlinear Circuits and Systems Laboratory
• ECE supporting Sunseeker Solar Rayce Team
• DOE Strategic Training and Education in Power Systems (STEPS) Funding

Software Test Automation, Phillip Laplante, Fevzi Belli, Jerry Gao, Greg Kapfhammer, Keith Miller, W. Wong, Dianxiang Xu

Education Sciences and Professional Programs Faculty Works

No abstract provided.

Synthesis, Structure, And Catalytic Properties Of Size-Selected Platinum Nanoparticles, Simon Armando Covone

Electronic Theses and Dissertations

The use of heterogeneous catalysis is well established in chemical synthesis, energy, and environmental engineering applications. Supported Pt nanoparticles have been widely reported to act as catalysts in a vast number of chemical reactions. In this report, the performance of Pt/ZrO2 nanocatalyst for the decomposition of methanol, ethanol, 2-propanol, and 2-butanol is investigated. The potential of each alcohol for the production of H2 and other relevant products in the presence of a catalyst is studied. All the alcohols studied show some decomposition activity below 200°C which increased with increasing temperature. In all cases, high selectivity towards H2 formation is observed. …

Design And Development Of An Integrated Waste Management System For Huai Nam Khun, Thailand, Annie Duong

Industrial and Manufacturing Engineering

Background

A rural village in Thailand has always been limited in access to waste collection services and processing facilities. As a result, their behaviors of disposing waste in ineffective manners such as dumping and burning causes a variety of environmental impacts. In addition, the people dwelling in these areas are often unaware of the health risks associated to these types of engagements because of the inadequate education system. For a long time coming these circumstances remained untouched until a non-profit organization recently shed light to the need for a solution. An investigation, to develop a design solution in order to …

Non-Planar Diamond Electrodes For Biomedical Neural Sensing And Stimulating, Jeffrey M. Halpern

Chemical Engineering

Abstract

Conductive diamond has exceptional chemical stability, making it an appealing candidate material for long-term medical device implants. This work describes the characterization, and fabrication of four diamond-based neural devices. A previously developed 30 µm diamond-disk in vitro needle electrode was characterized. The device could detect 1 nM concentration analytes in a flow cell using fast scan cyclic voltammetry, but the fabrication was not reproducible. A novel in vitro diamond device was developed with diamond selectively grown at the tip of a hollow quartz capillary, resulting in a 2-4 µm tip diameter. The diamond tip shape and size were geometrically …

Digester Selection And Operation For Heybeli Island, Spencer Fackler, Joseph Violetti

Industrial and Manufacturing Engineering

The Heybeli Digester project originated with Sema Alptekin in her personal research and was incorporated into a Senior Project opportunity at California Polytechnic State University, San Luis Obispo. The aim of this project was to select and design a plan for the use of a digester for the island of Heybeli, Turkey. The objective of this plan was to incorporate economic, social, and environmental justifications to evaluate if a digester would be a benefit to the community.

Systems Engineering analysis is a vital tool when working with complicated projects that include multiple systems interfacing with one another. Through the use …

The Systemic Correlation Between Mental Models And Sustainable Design: Implications For Engineering Educators, Linda Vanasupa, Roger Burton, Jonathan Stolk, Julie B. Zimmerman, Larry J. Leifer, Paul T. Anastas

Materials Engineering

Many studies have illuminated our understanding of the kinds of competencies and behaviors exhibited by effective designers. Against the backdrop of global challenges made more urgent by unintentional negative impacts of engineered products and systems, however, we are left to deduce that our ways of educating engineering designers is fundamentally flawed. We assert that one can trace the cause of our collective, unintended negative consequences to the mental models of reality that we consciously or unconsciously carry. In this paper, we present the case for developing awareness and facility with mental models. We also suggest an alternate mental model as …

Computational Models Of Thermal Cycling In Chemical Systems, Carl Barratt, Dante Lepore, Matthew Cherubini, Pauline Schwartz

Mechanical and Industrial Engineering Faculty Publications

Computational models of chemical systems provide clues to counterintuitive interactions and insights for new applications. We have been investigating models of chemical reaction systems under forced, thermal cycling conditions and have found that some hypothetical processes generate higher yields under thermal cycling than under single, fixed temperature conditions. A simple kinetic model of an actual process, the two-temperature polymerase chain reaction that replicates DNA, is used to simulate the important features of a chemical system operating under thermal cycling. This model provides insights into the design of other chemical systems that may have important applications in chemistry, biochemistry and chemical …

Hot Water, Dry Streams: A Tale Of Two Trout, Jack R. Tuholske

All In-stream Flows Material

Norman Maclean’s timeless memoir A River Runs Through It begins with the reflection that in his household “there was no clear line between religion and fly fishing.”¹ That zeal remains today; nearly 30 million Americans call themselves fishermen.² Anglers devoted an aggregate of 517 million user-days pursuing their passion in 2006 and spent billions of dollars to support it.³ Fishing in the western United States holds a special place in fishing lore the world over and for good reason. From the great trout waters of Montana, to the salmon-laden rivers of the west coast, to the sparkling …

Predictive Modeling Of Sulfide Removal In Tray Aerators, Jumoke O. Faborode

Electronic Theses and Dissertations

Hydrogen sulfide is commonly found in many Florida potable groundwater supplies. Removing sulfur species, particularly hydrogen sulfide is important because if left untreated, sulfide can impact finished water quality, corrosivity, create undesirable taste and odor, and oxidize to form visible turbidity and color. This document presents the results of a study designed to investigate the removal efficiencies of a variety of tray aerators in Central Florida in order to develop a predictive mathematical model that could be used to determine tray effectiveness for sulfide removal. A literature review was performed that indicated there was limited information regarding the removal of …

Genome-Scale Metabolic Analysis Of Clostridium Thermocellum For Bioethanol Production, Seth B. Roberts, Christopher M. Gowen, J. Paul Brooks, Stephen S. Fong

Chemical and Life Science Engineering Publications

Background

Microorganisms possess diverse metabolic capabilities that can potentially be leveraged for efficient production of biofuels. Clostridium thermocellum (ATCC 27405) is a thermophilic anaerobe that is both cellulolytic and ethanologenic, meaning that it can directly use the plant sugar, cellulose, and biochemically convert it to ethanol. A major challenge in using microorganisms for chemical production is the need to modify the organism to increase production efficiency. The process of properly engineering an organism is typically arduous.

Results

Here we present a genome-scale model of C. thermocellum metabolism, iSR432, for the purpose of establishing a computational tool to study the …

A Signal Processing Method To Explore Similarity In Protein Flexibility, Simina Vasilache, Nazanin Mirshahi, Soo-Yeon Ji, James Mottonen, Donald J. Jacobs, Kayvan Najarian

Computer Science Publications

Understanding mechanisms of protein flexibility is of great importance to structural biology. The ability to detect similarities between proteins and their patterns is vital in discovering new information about unknown protein functions. A Distance Constraint Model (DCM) provides a means to generate a variety of flexibility measures based on a given protein structure. Although information about mechanical properties of flexibility is critical for understanding protein function for a given protein, the question of whether certain characteristics are shared across homologous proteins is difficult to assess. For a proper assessment, a quantified measure of similarity is necessary. This paper begins to …

Ablation Of Chronic Total Occlusions Using Kilohertz-Frequency Mechanical Vibrations In Minimally Invasive Angioplasty Procedures., Garrett Mcguinness, Mark Wylie, Graham Gavin

Articles

Certain minimally invasive cardiology procedures, such as balloon angioplasty and stent implantation, critically require that the site of an arterial blockage be crossed by an intraluminal guidewire. Plaques resulting in near or totally occluded arteries are known as chronic total occlusions (CTOs), and crossing them with conventional guidewires is a significant challenge. Among the most promising proposed solutions is the delivery of high power, low frequency ultrasonic vibrations to the occlusion site via an intraluminal wire waveguide. The vibrating distal-tip of the ultrasound wire waveguide is used to transmit energy to the surrounding plaques, tissues and fluids in order to …

Stability And Dynamics Of Self-Similarity In Evolution Equations, Andrew J. Bernoff, Thomas P. Witelski

All HMC Faculty Publications and Research

A methodology for studying the linear stability of self-similar solutions is discussed. These fundamental ideas are illustrated on three prototype problems: a simple ODE with finite-time blow-up, a second-order semi-linear heat equation with infinite-time spreading solutions, and the fourth-order Sivashinsky equation with finite-time self-similar blow-up. These examples are used to show that self-similar dynamics can be studied using many of the ideas arising in the study of dynamical systems. In particular, the use of dimensional analysis to derive scaling invariant similarity variables is discussed, as well as the role of symmetries in the context of stability of self-similar dynamics. The …

Dual-Stage Sugar Substitution In Strawberries With A Stevia-Based Sweetener, Juan Garcia-Noguera, Curtis L. Weller, Francisca I. P. Oliveira, Sueli Rodrigues, Fabiano A. N. Fernandes

Department of Agricultural and Biological Systems Engineering: Faculty Publications

The present study introduces and analyzes a new process denominated dual-stage sugar substitution (D3S). This process aims to induce sugar substitution in strawberries. In a first stage, high-calorie sugars (sucrose, fructose and glucose) are partially removed from the fruit samples and in a second stage, low-calorie sugar (stevioside and rebaudioside) is incorporated to the fruit to maintain its sweetness. The process was evaluated by studying the use of ultrasound application in one or both stages of the D3S process. Best performance of the process was obtained by subjecting the fruit samples to ultrasound in the sugar removal stage followed by …

Santa Clara Magazine, Volume 51 Number 4, Spring 2010, Santa Clara University

Santa Clara Magazine

14 - BENDING LIGHT By Steven Boyd Saum. They wanted to show that green living is not a compromise. So, for the international Solar Decathlon, the SCU-led Team California built a house of light and wonder. And it was dazzling enough to win No. 3 on the planet.

22 - CONNECT THE DOTS By Scott Brown '93. From border security to disaster preparedness, Secretary of Homeland Security Janet Napolitano '79 has one immense portfolio. She's also the point person on immigration. How to put those together?

28 - THIS PLACE WE CALL HOME By Kristina Chiapella '09 '09. Generations ago, …

Influence Of Compressible Aerogel Electrodes On The Properties Of An Electrochemical Cell, Chris Sponheimer

Electronic Theses and Dissertations

In the biomedical field the need for intra organ pressure measurement can only be facilitated by adapting existing pressure sensing technology to the specific tissues under test. The customization of these sensors has only driven up cost and the need to explore new technologies has become increasingly more important. For this dissertation, we explore the use of a new technology, particularly electrochemical pressure sensing to provide a low-cost pressure sensor to fill this need. Preliminary testing showed that electrically conductive polymers exhibited a change in voltage when pressurized if bubbles were first electrolyzed in the gel creating an aerogel, and …

Status And Trend Of Cottonwood Forests Along The Missouri River, Mark D. Dixon, W. Carter Johnson, Michael L. Scott, Daniel Bowen

United States Army Corps of Engineers, Omaha District

From 2007-2009, we studied the current (2006) and historic (1892, mid-1950s) extent, current age distribution, and plant species composition of plains cottonwood (Populus deltoides) and non-cottonwood riparian stands along eight study segments of the Missouri River between Fort Benton, Montana and Kansas City Missouri, covering 930 river miles (1500 km) or over 1/3 of the river's length. These segments included all of the unchannelized and unimpounded segments below Fort Benton, as well as portions of two impounded and one channelized segment. Based on GIS analyses of historic maps and aerial photography, the combined area of forests, woodlands, and …

Pltw And Epics‐High: Curriculum Comparisons To Support Problem Solving In The Context Of Engineering Design, Todd Kelley, Daniel C. Brenner, John T. Pieper

Reports of Center Studies

A comparative study was conducted to compare two approaches to engineering design curriculum between different schools (inter-school) and between two curricular approaches, Project Lead the Way (PLTW) and Engineering Projects in Community Service (EPIC High) (inter-curricular). The researchers collected curriculum materials, including handouts, lesson plans, guides, presentation files, design descriptions, problem statements, and support guides. The researchers conducted observations in the classrooms to collect qualitative indicators of engineering/technology reasoning, collect data on the nature of students‟ questions, how students define problems, and operate within the constraints of a design problem.

Observational studies were conducted with students participating in Project Lead …

Xperts And Novices: Differences In Their Use Of Mental Representation And Metacognition In Engineering Design, Raymond Anthony Dixon

Dissertations

Research shows that mental representation such as analogical reasoning is a fundamental cognitive tool for design problem solving (Daugherty & Mentzer, 2008; Hey, Lensey, Agogino, & Wood, 2008; Lewis, 2008). Not much is known, however, about the way students and professional engineers actively generate and change their mental representation when solving a engineering design problem. There are very few studies that show how different types of mental representations; such as metaphors, propositions, and analogies; interplay with higher order cognitive processes; such as planning, monitoring, and evaluation; as engineering designers navigate their problem and solution spaces. This empirical study investigated the …

A Case Study: Teaching Engineering Concepts In Science, David R. Stricker

Reports of Center Studies

This study was conducted to describe a teacher developed high school engineering course, to identify teaching strategies used in the process of delivering math and science literacy through this course, to identify challenges and constraints that occurred during its development and delivery, and to describe the strategies that were used to overcome those obstacles.

A case study was conducted using semi-structured interviews with the engineering instructor at Benilde-St. Margaret's in St. Louis Park, Minnesota. In addition, the researcher conducted classroom observations and reviewed instructional materials, teacher lesson plans, and teacher journals.

Themes that developed regarding the strategies used to deliver …

Design, Development And Biomechanical Analysis Of Scaffolds For Augmentation Of Rotator Cuff Repairs, Amit Aurora

ETD Archive

Rotator cuff tears are a source of debilitating pain that commonly affects more than 40 of our aging population. Despite advances in surgical treatment, the failure rate of rotator cuff repairs is as high as 20-90 . Extracellular matrix (ECM) derived scaffolds have recently been investigated as augmentation devices for rotator cuff repairs, but none has yet demonstrated both the appropriate biological and mechanical properties for mitigating re-tears and enhancing healing. This dissertation proposes to engineer the mechanical properties of allograft fascia lata in a manner that will allow its use as an augmentation device for rotator cuff repairs. This …

Surface Microtopography Modulation Of Biomaterials For Bone Tissue Engineering Applications, Eun Jung Kim

ETD Archive

The ultimate goal of this project is to develop a biodegradable and implantable scaffold with precise surface topographies that can provide osteoconductive stimuli to connective tissue progenitor cells (CTPs), and subsequently, enhance bone regeneration applications without the complications of autogenous cancellous bone grafts. This dissertation presents the modification of surface microtextures to provide osteoconductive stimuli to CTPs for bone regeneration applications. First, the effect of surface topography on cell proliferation and osteogenic differentiation was validated through experiments using surface post microtextures and CTPs. Post microtextures accelerated CTP growth behaviors compared to smooth polydimethylsiloxane (PDMS) and standard cell culture dishes. Second, …