Digital Commons Network^™

Design And Control Of Flapping Wing Micro Air Vehicles, Michael L. Anderson

Theses and Dissertations

Flapping wing Micro Air Vehicles (MAVs) continues to be a growing field, with ongoing research into unsteady, low Re aerodynamics, micro-fabrication, and fluid-structure interaction. However, research into flapping wing control of such MAVs continues to lag. Existing research uniformly consists of proposed control laws that are validated by computer simulations of quasi-steady blade-element formulae. Such simulations use numerous assumptions and cannot be trusted to fully describe the flow physics. Instead, such control laws must be validated on hardware. Here, a novel control technique is proposed called Bi-harmonic Amplitude and Bias Modulation (BABM) which can generate forces and moments in 5 …

A Novel Malware Target Recognition Architecture For Enhanced Cyberspace Situation Awareness, Thomas E. Dube

Theses and Dissertations

The rapid transition of critical business processes to computer networks potentially exposes organizations to digital theft or corruption by advanced competitors. One tool used for these tasks is malware, because it circumvents legitimate authentication mechanisms. Malware is an epidemic problem for organizations of all types. This research proposes and evaluates a novel Malware Target Recognition (MaTR) architecture for malware detection and identification of propagation methods and payloads to enhance situation awareness in tactical scenarios using non-instruction-based, static heuristic features. MaTR achieves a 99.92% detection accuracy on known malware with false positive and false negative rates of 8.73e-4 and 8.03e-4 respectively. …

Identification And Classification Of Player Types In Massive Multiplayer Online Games Using Avatar Behavior, Earl M. Bednar

Theses and Dissertations

The purpose of our research is to develop an improved methodology for classifying players (identifying deviant players such as terrorists) through multivariate analysis of data from avatar characteristics and behaviors in massive multiplayer online games (MMOGs). To build our classification models, we developed three significant enhancements to the standard Generalized Regression Neural Networks (GRNN) modeling method. The first enhancement is a feature selection technique based on GRNNs, allowing us to tailor our feature set to be best modeled by GRNNs. The second enhancement is a hybrid GRNN which allows each feature to be modeled by a GRNN tailored to its …

A Modified Surface On Titanium Deposited By A Blasting Process, Caroline O' Sullivan, Peter O'Hare, Greg Byrne, Liam O'Neill, Katie B. Ryan, Abina M. Crean

Publications

Abstract

: Hydroxyapatite (HA) coating of hard tissue implants is widely employed for its biocompatible and osteoconductive properties as well as its improved mechanical properties. Plasma technology is the principal deposition process for coating HA on bioactive metals for this application. However, thermal decomposition of HA can occur during the plasma deposition process, resulting in coating variability in terms of purity, uniformity and crystallinity, which can lead to implant failure caused by aseptic loosening. In this study, CoBlast™, a novel blasting process has been used to successfully modify a titanium (V) substrate with a HA treatment using a dopant/abrasive regime. …

Understanding Formation And Transport Of Amorphous Iron Oxyhydroxides In Porous Media Using Microfluidic Flow Cells- A Novel Method To Study Freshwater Iron Cycling, Neha A. Ghaisas

Master's Theses

The ground water and surface water interface (GSI or Hyporheic zone) is a spatially- and temporally-fluctuating biogeochemical transition zone connecting these two distinct hydrological components. The mixing zone is characterized by a near neutral pH, ambient temperature and a sharp oxygen concentration which in turn has deep impact on the iron cycling and thus the fate of contaminants in the water column. We constructed an experimental micromodel that to observe key processes that affect biogeochemical iron cycling in the fresh water interface zones where the oxic surface water mixes with Fe (II) rich underlying ground water. The flow cell was …

2011 Fall Engr333 Project Assignment, Matthew K. Heun

ENGR 333

The Fall 2011 ENGR333 project focused on the Bunker Interpretive Center (BIC) at Calvin University.

I asked the students “What would it take for Calvin College to obtain an Energy Star rating for the BIC? Or, if the BIC already qualifies for an Energy Star rating, what would it take to improve the energy efficiency of the BIC (as measured by Energy Star metrics) by 15%, thereby ensuring Energy Star performance of the building into the future?”

Customer

As I recall, the customer for this project was Biology faculty member Randy Van Dragt.

Bioenergy Feedstock-Specific Enrichment Of Microbial Populations During High-Solids Thermophilic Deconstruction, Amitha P. Reddy, Martin Allgaier, Steven W. Singer, Terry C. Hazen, Blake A. Simmons, Philip Hugenholtz, Jean S. Vandergheynst

United States Department of Energy: Publications

Thermophilic microbial communities that are active in a high-solids environment offer great potential for the discovery of industrially relevant enzymes that efficiently deconstruct bioenergy feedstocks. In this study, finished green waste compost was used as an inoculum source to enrich microbial communities and associated enzymes that hydrolyze cellulose and hemicellulose during thermophilic high-solids fermentation of the bioenergy feedstocks switchgrass and corn stover. Methods involving the disruption of enzyme and plant cell wall polysaccharide interactions were developed to recover xylanase and endoglucanase activity from deconstructed solids. Xylanase and endoglucanase activity increased by more than a factor of 5, upon four successive …

Segmentation Of Non-Stationary Gene Expression Profiles Using Statistical Sequential Analysis, Jasmine Pahari

Theses and Dissertations

Due to the dynamic nature of biological systems, gene expression data underlying temporal processes, such as the cell development or a disease progression, can exhibit significant regime changes to facilitate regulatory functions. Deciphering these dynamical changes is crucial to understanding the biological function and developing time-varying models of cellular evolution. In this thesis, we propose to detect the different dynamical regimes of gene expression profiles using statistical sequential analysis. The proposed algorithm segments the gene time-series into distinct homogeneous regimes of expression, during which the underlying dynamics of the gene can be assumed to be stationary. Finding the switch point …

Targeting Breast Cancer Detection With Communications Technology, Hacer Varol

Theses and Dissertations

Breast cancer continues to be a significant public health problem in the United States: It is the second leading cause of female mortality, and, disturbingly, one out of eight women in the United States will be diagnosed with breast cancer in her life time. Until the cause of this disease is fully understood, early detection remains the only hope to improve prognosis and treatment. In this thesis, the tumor detection problem in breast images is formulated as a hypothesis testing problem, where the signal of interest is the tumor and the noise refers to the healthy tissue in the breast. …

Spatial And Temporal Variation Of Rod Photoreceptor Reflectance In The Human Retina, Robert F. Cooper, Adam M. Dubis, Ashavini M. Pavaskar, Jungtae Rha, Alfredo Dubra, Joseph Carroll

Biomedical Engineering Faculty Research and Publications

Using adaptive optics imaging tools to image the living retina, numerous investigators have reported temporal fluctuation in the reflectivity of individual cone photoreceptors. In addition, there is cone-to-cone (spatial) variation in reflectivity. As it has only recently become possible to image the complete rod photoreceptor mosaic in the living human retina, we sought to characterize the reflectivity of individual rods and compare their behavior to that of foveal/parafoveal cones. Across two subjects, we were able to successfully track the reflectance behavior of 1,690 rods and 1,980 cones over 12 hours. Rod and cone photoreceptors showed similar regional and temporal variability …

Thirdhand Tobacco Smoke: Emerging Evidence And Arguments For A Multidisciplinary Research Agenda, Georg E. Matt, Penelope J. Quintana, Hugo Destaillats, Lara A. Gundel, Mohamad Sleiman, Brett C. Singer, Peyton Jacob, Jonathan P. Winickoff, Prue Talbot, Suzaynn Schick, Yinsheng Wang, Bo Hang, Manuela Martins-Green, James F. Pankow, Melbourne F. Hovell, Neal L. Benowitz, Virender K. Rehan, Jonathan M. Samet

Civil and Environmental Engineering Faculty Publications and Presentations

There is broad consensus regarding the health impact of tobacco use and secondhand smoke exposure, yet considerable ambiguity exists about the nature and consequences of thirdhand smoke (THS). We introduce definitions of THS and THS exposure and review recent findings about constituents, indoor sorption-desorption dynamics, and transformations of THS; distribution and persistence of THS in residential settings; implications for pathways of exposure; potential clinical significance and health effects; and behavioral and policy issues that affect and are affected by THS. Physical and chemical transformations of tobacco smoke pollutants take place over time scales ranging from seconds to months and include …

Modeling The Collagen Fibril Network Of Biological Tissues As A Nonlinearly Elastic Material Using A Continuous Volume Fraction Distribution Function, Reza Shirazi, Pasquale Vena, Robert L. Sah, Stephen M. Klisch

Mechanical Engineering

Despite distinct mechanical functions, biological soft tissues have a common microstructure in which a ground matrix is reinforced by a collagen fibril network. The microstructural properties of the collagen network contribute to continuum mechanical tissue properties that are strongly anisotropic with tensile-compressive asymmetry. In this study, a novel approach based on a continuous distribution of collagen fibril volume fractions is developed to model fibril reinforced soft tissues as nonlinearly elastic and anisotropic material. Compared with other approaches that use a normalized number of fibrils for the definition of the distribution function, this representation is based on a distribution parameter (i.e. …

Analysis Of Migration Models Of Biogeography-Based Optimization Using Markov Theory, Haiping Ma, Daniel J. Simon

Electrical and Computer Engineering Faculty Publications

Biogeography-based optimization (BBO) is a new evolutionary algorithm inspired by biogeography, which involves the study of the migration of biological species between habitats. Previous work has shown that various migration models of BBO result in significant changes in performance. Sinusoidal migration models have been shown to provide the best performance so far. Motivated by biogeography theory and previous results, in this paper a generalized sinusoidal migration model curve is proposed. A previously derived BBO Markov model is used to analyze the effect of migration models on optimization performance, and new theoretical results which are confirmed with simulation results are obtained. …

Protective Effects Of Milk Phospholipids Against Uv Photodamage In Human Skin Equivalents, Zyra Achay

Master's Theses

The ultraviolet (UV) spectrum has been known to cause damage to skin in varying degrees. UVB radiation (290-320 nm) in particular, has been proven to be highly mutagenic and carcinogenic in many animal experiments compared to either UVA or UVC. The alarming rate of increase in skin cancer incidence has prompted many investigators to pursue other alternatives to sunscreens including changes in lifestyle habits and dietary consumption in order to boost our efforts in tackling this widespread disease. Previous studies employing confocal reflectance, MTT assay and histology suggest that milk phospholipids may possess protective properties against UVB-mediated damage but the …

Improved Manufacturing Methods Of Bovine Femur Samples For Ultrasonic Testing And Assessment Of Materials Through Contract Angle Measurement, Kevin Mathew Lopez Galang

Biomedical Engineering

At California Polytechnic State University of San Luis Obispo (Cal Poly), the Biomedical Engineering department (BMED) requires its students to take the course listed as “BMED 420: Principles of Biomaterial Designs.” BMED 420 has a required laboratory section every week throughout the duration of the course that is meant to be a supplemental tool for learning. During the lab sections, students perform experiments and exercises that are currently being implemented in the industry. Despite accuracy of the methods and experiments relative to their use in the industry, there is always room for improvement. The objective of this project will illustrate …

Impaired Resistance Artery Reactivity Following Arteriogenesis, Michael (Mike) Machado

Biomedical Engineering

No abstract provided.

Robust Cns Regeneration After Complete Spinal Cord Transection Using Aligned Poly-L-Lactic Acid Microfibers, Andres Hurtado, Jared M. Cregg, Han B. Wang, Dane F. Wendell, Martin Oudega, Ryan J. Gilbert, John W. Mcdonald

Chemical and Biochemical Engineering Faculty Research & Creative Works

Following spinal cord injury, axons fail to regenerate without exogenous intervention. In this study we report that aligned microfiber-based grafts foster robust regeneration of vascularized CNS tissue. Film, random, and aligned microfiber-based conduits were grafted into a 3 mm thoracic rat spinal cord gap created by complete transection. Over the course of 4 weeks, microtopography presented by aligned or random poly- l-lactic acid microfibers facilitated infiltration of host tissue, and the initial 3 mm gap was closed by endogenous cell populations. This bulk tissue response was composed of regenerating axons accompanied by morphologically aligned astrocytes. Aligned fibers promoted long distance …

Hyperspectral-Based Adaptive Matched Filter Detector Error As A Function Of Atmospheric Profile Estimation, Allan W. Yarbrough

Theses and Dissertations

Hyperspectral imagery is collected as radiance data. This data is a function of multiple variables: the radiation profile of the light source, the reflectance of the target, and the absorption and scattering profile of the medium through which the radiation travels as it reflects off the target and reaches the imager. Accurate target detection requires that the collected image matches as closely as possible the known "true" target in the classification database. Therefore, the effect of the radiation source and the atmosphere must be removed before detection is attempted. While the spectrum of solar light is relatively stable, the effect …

Theoretical Prediction Of Drug Release In Gi Tract From Spherical Matrix Systems, Naga Lakshmi Ramana Susarla

Dissertations

The significance of controlled release drug delivery systems (CRDDS) lies in their ability to deliver the drug at a steady rate thus reducing the dosage interval and providing a prolonged pharmacodynamic effect. But despite the steadily increasing practical importance of these devices, little is known regarding their underlying drug release mechanisms. Mathematical modeling of these drug delivery systems could help us understand the underlying mass transport mechanisms involved in the control of drug release. Mathematical modeling also plays an important role in providing us with valuable information such as the amount of drug released during a certain period of time …

The Impact Of Dynamic And Passive Standing On Bone Mineral Density And Appositional Growth In Immobilized Children, Megan Diane Damcott

Dissertations

The first discovery of the potential role that mechanical loading has on determining the strength of bone occurred in 1892. However, for almost a century after this discovery, the specific mechanisms influenced by mechanical loading remained locked in a mysterious 'black box'. Then in the 1960s, the 'black box' was opened and continued work has now unlocked the basic mechanisms involved in mechanical loading and whole-bone strength. This increased knowledge has spurred clinicians and researchers to investigate the impact of weight-bearing interventions on individuals with an increased risk of osteoporosis. The most common weight-bearing clinical intervention used in non-ambulant populations …

Effects Of Operating And Geometric Variables On Hydrodynamics And Tablet Dissolution In Standard And Modified Dissolution Testing Apparatuses 2, Yimin Wang

Dissertations

Dissolution testing is routinely conducted in the pharmaceutical industry to provide critical in vitro drug release information for quality control purposes, and especially to assess batch-to-batch consistency of solid oral dosage forms such as tablets. Among the different types of apparatuses listed in the United States Pharmacopoeia (USP), the most commonly used dissolution system for solid dosage forms is the USP Dissolution Testing Apparatus 2, consisting of an unbaffled, hemispherical-bottomed vessel equipped with a 2-blade radial impeller.

Despite its extensive use in industry and a large body of work, some key aspects of the hydrodynamics of Apparatus 2 have received …

Multifunctional Reactive Nanocomposite Materials, Demitrios Stamatis

Dissertations

Many multifunctional nanocomposite materials have been developed for use in propellants, explosives, pyrotechnics, and reactive structures. These materials exhibit high reaction rates due to their developed reaction interfacial area. Two applications addressed in this work include nanocomposite powders prepared by arrested reactive milling (ARM) for burn rate modifiers and reactive structures. In burn rate modifiers, addition of reactive nanocomposite powders to aluminized propellants increases the burn rate of aluminum and thus the overall reaction rate of an energetic formulation. Replacing only a small fraction of aluminum by 8Al•MoO₃ and 2B•Ti nanocomposite powders enhances the reaction rate with little change …

Use Of Fluorescent Micropsheres To Measure Coronary Flow Reserve In Rat Animal Model, Riddhi Harsh Shah

Theses

Heart attacks result from reduced or blocked blood flow through major coronary arteries, resulting in permanent damage to heart muscle. Coronary blood flow (CBF) is thus important to measure in experimental animal models of heart disease. A standard method to measure CBF uses tracer microspheres (Ø = 15 µm) injected into the left ventricle that flow through coronary arteries but cannot pass through capillaries and so become trapped in heart muscle. Previously, radioactive or colored microspheres have quantified the number of tracers trapped in the muscle. Fluorescent microspheres offer a more recent and more sensitive measurement mode. However, fluorescent microspheres …

Effects Of Non-Planar Distortions In Porphyrin Compounds On Their Properties And Functionality, Raid Haddad

Chemical and Biological Engineering ETDs

Porphyrins and related compounds are ubiquitous in nature, performing diverse functions including solar energy transduction, electron transport, molecular transport and storage, and catalysis. Due to their unique photophysical and chemical properties, they are excellent candidates for application as photosensitizers, catalysts, photocatalysts, molecular electronics and opto-electronics. Several properties of porphyrins are sensitive to small variations in their structure, and this dissertation investigates the effects of out-of-plane distortions of the macrocycle on optical properties, reactivity to axial ligands, and substituent rotation. The structure-functions relationships are examined using molecular simulations, UV-visible absorption spectroscopy, resonance Raman spectroscopy, and normal-coordinate structural decomposition (NSD) analysis of …

Novel Routes For Synthesis Of Pd Nanoparticles And Faceted Zno Supports For Heterogeneous Catalysts, Patrick David Burton

Chemical and Biological Engineering ETDs

Alcohol steam reforming is a promising source of hydrogen as fuel, and could be improved by the use of an optimal catalyst. The methanol steam reforming reaction, CH3OH+H2O --> 3H2+CO2 frequently conducted by means of a Cu/ZnO catalyst. Unfortunately, this catalyst deactivates quickly and is pyrophoric. Pd catalysts are much more stable, but reactions using these catalyst follow the decomposition pathway, CH3OH --> 2H2+CO. PdZn alloys can achieve the desired selectivity, and have been noted to form under reaction conditions from Pd/ZnO heterogeneous catalysts. In the present work, careful synthesis techniques of specific support and nanoparticle surfaces have been developed …

Polymerization In Emulsion Microdroplet Reactors, Nick J. Carroll

Chemical and Biological Engineering ETDs

The goal of this research project is to utilize emulsion droplets as chemical reactors for execution of complex polymerization chemistries to develop unique and functional particle materials. Emulsions are dispersions of immiscible fluids where one fluid usually exists in the form of drops. Not surprisingly, if a liquid-to-solid chemical reaction proceeds to completion within these drops, the resultant solid particles will possess the shape and relative size distribution of the drops. The two immiscible liquid phases required for emulsion polymerization provide unique and complex chemical and physical environments suitable for the engineering of novel materials. The development of novel non-ionic …

On The Effects Of Graph Based Evolutionary Algorithms For Training Finite State Classifiers, Steven M. Corns

Engineering Management and Systems Engineering Faculty Research & Creative Works

This work presents a method for evolving finite state machines for the classification of polymerase chain reaction primers in mice using graph based evolutionary algorithms. using these machine learning tools we can compensate for many lab, organism, and chemical specific factors that can cause these primers to fail. using Finite State Classifiers can help to decrease the number of primers that fail to amplify correctly. for training these classifiers, fifteen different graph based evolutionary algorithms were used in two different experiments to explore the effects of diversity preservation on the development of these classifiers. by controlling the rate at which …

Left Ventricular Assist Devices: Engineering Design Considerations, Marwan A. Simaan, Eduardo Divo, George Faragallah, Yu Wang

Publications

Patients with end-stage congestive heart failure awaiting heart transplantation often wait long periods of time (300 days or more on the average) before a suitable donor heart becomes available. The medical community has placed increased emphasis on the use of Left Ventricular Assist Devices or LVADs that can substitute for, or enhance, the function of the natural heart while the patient is waiting for the heart transplant (Poirier, 1997; Frazier & Myers, 1999). Essentially, a rotary LVAD is a pump that operates continuously directing blood from the left ventricle into the aorta by avoiding the aortic valve. Generally speaking, the …

Femtosecond Laser Fabricated All-Optical Fiber Sensors With Ultrahigh Refractive Index Sensitivity: Modeling And Experiment, Lan Jiang, Longjiang Zhao, Sumei Wang, Jinpeng Yang, Hai Xiao

Mechanical and Aerospace Engineering Faculty Research & Creative Works

All-optical fiber sensors based on ultracompact fiber inline Mach-Zehnder interferometer (MZI) are fabricated by side-ablating a Ushape microcavity in a single-mode optical fiber with the fiber core partially removed using femtosecond (fs) laser pulses, in which the two light paths are accordingly formed in the remaining D-type fiber core and the U-shape microcavity. Beam propagation method (BPM) analysis is utilized to illustrate the dependences of good transmission spectra on parameters including the ablation depth, ablation length and the refractive index of Ushape microcavity, which gives some guidelines to optimize parameters for fs laser micromachining and predicts RI (refractive index) sensitivities …

Study On The Fluorescent Carbon Nanodots With Electrochemical Methods, Bao-Ping Qi, Yan-Min Long, Lei Bao, Cui Liu, Zhi-Ling Zhang, Dai-Wen Pang

Journal of Electrochemistry

Carbon nanodots are a new class of fluorescent nanoparticles with a carbon-based core, which possess wavelength-tunable luminescence, high photostability, resistance to photobleaching, water-solubility, and ease of bioconjugation. Owing to their attractive merits, carbon nanodots like other carbon nanomaterials such as fullerene, carbon nanotubes and graphene, have attracted much attention. In addition, carbon nanodots can be inexpensively produced by electrochemical methods with simple post-processing under mild conditions. Electrochemical approaches have unique advantages in the analysis of surface structures and luminescence mechanism of materials. In this review, recent advances in electrochemical methods used for the synthesis and luminescence mechanism of fluorescent carbon …