Digital Commons Network^™

En Route Towards Α-Benzotriazoyl Nitroso Derivatives, Jean-Christophe M. Monbaliu, Lucas K. Beagle, Judit K. Beagle, Matthias Zeller, Christian V. Stevens, Alan R. Katritzky

Chemistry Faculty Publications

A new class of geminally-substituted nitroso compounds, i.e., α-benzotriazoyl nitroso derivatives, is presented. These compounds display a rather different behavior than other related nitroso compounds bearing a geminal electron-withdrawing group. An unexpected and spontaneous oxidation to the nitro analog is observed in solution.

Characterization Of An Advanced Neuron Model, Christopher Echanique

HIM 1990-2015

This thesis focuses on an adaptive quadratic spiking model of a motoneuron that is both versatile in its ability to represent a range of experimentally observed neuronal firing patterns as well as computationally efficient for large network simulation. The objective of research is to fit membrane voltage data to the model using a parameter estimation approach involving simulated annealing. By manipulating the system dynamics of the model, a realizable model with linear parameterization (LP) can be obtained to simplify the estimation process. With a persistently excited current input applied to the model, simulated annealing is used to efficiently determine the …

Analysis Of The Effect Of Feeding Regimen On Gh/Igf Axis In Channel Catfish (Ictalurus Punctatus), Samantha Puckett

Biological and Agricultural Engineering Undergraduate Honors Theses

Channel catfish (Ictalurus punctatus) are the most widely farmed aquatic animal in the United States. Assessing the effect of feeding regimens on their overall growth requires grow-out trials and a subsequent inefficient use of time and money. The growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis regulates growth based upon environmental factors such as feed intake in many teleost fish species. In order to increase the efficiency of aquaculture, the components of the GH/IGF-1 axis might be used as endocrine biomarkers to evaluate instantaneous growth rate. The goal of this study was to better understand the effects of feeding regimen on …

Improved Microalgal Biomass Harvesting Using Optimized Environmental Conditions And Bacterial Bioflocculants, Derek C. Manheim

Master's Theses

ABSTRACT

IMPROVED MICROALGAL BIOMASS HARVESTING USING OPTIMIZED ENVIRONMENTAL CONDITIONS AND BACTERIAL BIOFLOCCULANTS

DEREK CONTE MANHEIM

The cost and energy balance of microalgae biofuel production is sensitive to the algae harvesting method, among many other factors. Bioflocculation and settling of suspended microalgae cultures is a harvesting method with potentially low cost and energy input. However, bioflocculation (the spontaneous flocculation of algal cells without chemical addition) has not been a reliable process with cultures grown in ponds. To provide insights to help improve algae settling, factors affecting the settling of algae were investigated in the laboratory using pure cultures of two common …

Two-Dimensional Blood Flow Velocity Estimation Using Ultrasound Speckle Pattern Dependence On Scan Direction And Velocity, Tiantian Xu

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Cardiovascular disease is the leading cause death in the United States. Although emergency surgery and medicine can be used for cardiovascular disease treatment, the survivors will suffer for it afterwards. Ultrasound blood flow measurement provides a noninvasive way for cardiovascular diseases diagnosis. In this dissertation, three algorithms for blood flow velocity measurements were investigated and optimized. Feature tracking has been previously proposed for vector velocity measurement. In Chapter 3, the optimal amplitude and time thresholds for feature extraction were investigated to minimize flow estimate variance while providing sufficient spatial and temporal coverage of flow area. A new method of lateral …

Gpu-Accelerated Modeling Of Microscale Atmospheric Flows Over Complex Terrain, Anthony Rey Deleon

Boise State University Theses and Dissertations

With installed wind power capacities steadily on the rise, balancing the loads on electrical grids is challenging due to the intermittency of the wind. Short-term wind power forecasting can be a valuable tool for better informing grid operators on the available wind power. Current short-term wind forecasting techniques typically adopt mesoscale weather forecasting models with spatial resolutions on the order of a kilometer. On relatively flat terrain, use of mesoscale models may prove effective, but application to complex terrain induces large forecasting errors. To address this issue, a baseline incompressible flow solver for GPU (graphics processing unit) clusters is extended …

Mesh Generation Using A Correspondence Distance Field, Nicholas Szapiro

Masters Theses and Doctoral Dissertations

The central tool of this work is a correspondence distance field to discrete surface points embedded within a quadtree data structure. The theory, development, and implementation of the distance field tool are described, and two main applications to two-dimensional mesh generation are presented with extension to three-dimensional capabilities in mind. First is a method for surface-oriented mesh generation from a sufficiently dense set of discrete surface points without connectivity information. Contour levels of distance from the body are specified and correspondences oriented normally to the contours are created. Regions of merging fronts inside and between objects are detected in the …

Waste Heat Utilization In An Anaerobic Digestion System, Brett Boissevain

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Anaerobic digestion has great potential as an energy source. Not only does it provide an effective method for waste mitigation, but it has the potential to generate significant quantities of fuel and electricity. In order to ensure efficient digestion and biomass utilization, however, the system must be continuously maintained at elevated temperatures. It is technically feasible to supplement such a system with outside energy, but it is more cost effective to heat the system using only the produced biogas. While there is considerable literature covering the theory of anaerobic digestion, there are very few practical studies to show how heat …

Root Uptake Of Organic Contaminants Into Plants: Species Differences, Naho Orita

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Xenobiotic organic contaminants are widely found in the environment, including soils, sediments, surface waters, wastewater streams, and even in drinking water. Food chain contamination resulting from the uptake of these contaminants by plants is a concern. Although the uptake of a variety of xenobiotic organic contaminants by plants has been reported but the differences between plant species are not fully understood. The emphasis of this thesis research is to further investigate the unique root to shoot transfer ability of “gold rush” zucchini that has been reported repeatedly in recent years.

A pressure chamber technique was used to measure transpiration stream …

Experimental Studies Of Vertical Mixing In An Open Channel Raceway For Algae Biofuel Production, Ram Sudheer Voleti

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The USU BioEnergy Center has been successful in developing algae feedstocks for renewable biofuels and bioproducts. The concept is to utilize and maximize algae feedstocks for liquid transportation fuels, biomass for burning and digestion, and high value co-products. It is theorized that increasing the mixing in open and closed algal production systems improves the productivity of the algae culture. A raceway cultivation system was chosen to examine the phenomena of mixing. Vertical mixing will provide more uniform exposure to sunlight for all of the algae in the raceway. The main focus of this research was to increase vertical mixing. Delta …

The Antimycobacterial Activity Of Hypericum Perforatum Herb And The Effects Of Surfactants, Shujie Shen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Tuberculosis is a stubborn and lethal infectious disease. The world-wide tuberculosis surveillance reports that the new TB cases ranges from seven to eight million per year and deaths ranges from 1.3 to 1.6 million every year. The treatment of tuberculosis mainly depends on antituberculosis drugs, such as isoniazid, rifampin, pyrazinamide and ethambutol. However, drug-resistance acquisition is an inevitable process during tuberculosis treatment. Today, multi-drug resistant and the extensively drug-resistant TB cases have been widely reported around the world. Thus, the discovery of novel antituberculosis drugs is essential to effective TB treatment. Hypericum perforatum, also called St. John’s Wort, is …

Value Of Information In Design Of Groundwater Quality Monitoring Network Under Uncertainty, Abdelhaleem I. Khader

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Due to variations in rainfall and limited surface water resources, groundwater is considered the main source for freshwater in many places throughout the word. But this precious resource is being jeopardized by pollution from human activities such as: industry, agriculture, and untreated wastewater, which highlight the need for efficient groundwater resources management. To be efficient, groundwater resources management requires efficient access to reliable information that can be acquired through monitoring. On the other hand, the complicated nature of groundwater aquifers and the uncertainties in the data and the models used to understand the aquifer and its behavior require more powerful …

Purification Of Fibrinogen From Human Plasma, Ayman E. Ismail

Department of Chemical and Biomolecular Engineering: Dissertations, Theses, and Student Research

A solvent detergent treated fibrinogen was purified from human plasma by cryoprecipitation (cryo) followed by chemical precipitation using ethanol (EtOH) or ammonium sulfate (AS) as precipitating agents. Amounts of fibronectin (FN), factor XIII A-subunit (FXIIIA), factor XIII b-subunit (FXIIIB), and alpha₂-antiplasmin (α₂-AP) in the isolated fibrinogen were quantified. Thromboelastography (TEG) analysis was used to evaluate the clot strength of the isolated fibrinogen and to determine the ability of the ethanol and ammonium sulfate precipitations to eliminate the solvent detergent. Sodium dodecylsulfate-polyacrylamide gel analysis indicated that fibrinogen produced by each of these precipitation methods had similar purity. …

Design Of Advanced Fouling-Resistant And Self-Cleaning Membranes For Treatment Of Oily And Impaired Waters, Daniel Wandera

All Dissertations

The overall goal of my Doctor of Philosophy (PhD) research was to design and develop advanced anti-fouling and self-cleaning membranes for treating impaired waters. Initial work focused on the development of membranes to treat produced water, which is oily wastewater that is co-produced during oil and gas exploration. Economical, environmentally sustainable treatment of the large volumes of produced water is a grand challenge for oil and gas companies. While membranes offer many advantages over more conventional treatment methods, membrane-based treatment processes for oily waters often fail due to membrane fouling. Therefore, the primary objective of my doctoral research was to …

Engineering Single-Molecule, Nanoscale, And Microscale Bio-Functional Materials Via Click Chemistry, Michael Daniele

All Dissertations

To expand the design envelope and supplement the materials library available to biomaterials scientists, the copper(I)-catalyzed azide-alkyne cycloaddition (CuCAAC) was explored as a route to design, synthesize and characterize bio-functional small-molecules, nanoparticles, and microfibers. In each engineered system, the use of click chemistry provided facile, bio-orthogonal control for materials synthesis; moreover, the results provided a methodology and more complete, fundamental understanding of the use of click chemistry as a tool for the synergy of biotechnology, polymer and materials science. Fluorophores with well-defined photophysical characteristics (ranging from UV to NIR fluorescence) were used as building blocks for small-molecule, fluorescent biosensors. Fluorophores …

2d Modeling Of Forcespinning™ Nanofiber Formation With Experimental Study And Validation, Simon Padron

Theses and Dissertations - UTB/UTPA

A newly developed method of producing nanofibers, called Forcespinning™, has proven to be a viable alternative to mass produce nanofibers. Forcespinning™ utilizes centrifugal forces which allow for a host of new materials to be processed into nanofibers while also providing a significant increase in yield and ease of production. To improve and enhance the Forcespinning™ production method, a 2D computational Forcespinning™ fluid dynamics model is developed. Three computer models, namely time-independent and time-dependent inviscid models and a viscous model are obtained and the influences of various parameters on Forcespinning™ fiber formation are obtained. This work also presents a detailed explanation …

Semiconductor Nanocrystals: From Quantum Dots To Quantum Disks, Zheng Li

Graduate Theses and Dissertations

The bottom-up colloidal synthesis opened up the possibility of finely tuning and tailoring the semiconductor nanocrystals. Numerous recipes were developed for the preparation of colloidal semiconductor nanocrystals, especially the traditional quantum dots. However, due to the lack of thorough understanding to those systems, the synthesis chemistry is still on the empirical level. CdS quantum dots synthesis in non-coordinating solvent were taken as a model system to investigate its molecular mechanism and formation process, ODE was identified as the reducing agent for the preparation of CdS nanocrystals, non-injection and low-temperature synthesis methods developed. In this model system, we not only proved …

Characterization And Quantification Of Monomers, Oligomers, And By-Products From Xylan During Biomass Pretreatment, Ching-Shuan Lau

Graduate Theses and Dissertations

Biomass pretreatment generates inhibitory products, which reduce the overall yield of xylose for ethanol production. Understanding of hemicellulose depolymerization into xylose is essential to identify the pretreatment conditions that maximize xylose formation, but minimize the generation of these inhibitory products, such as formic acid and furfural. Thus, the goal of this project is to understand how dilute acid pretreatment parameters affect hemicellulose depolymerization, maximize xylose concentrations, and minimize by-products formation.

To progress towards this goal, rates and mechanisms of hemicellulose release must be determined. Birchwood xylan was used as the starting material to produce xylose oligomers. The hydrolyzed birchwood xylan …

Optimization Of A Dynamic Hot Water Pretreatment Of Switchgrass Using Catalysis By Carbonation To Maximize Carbochemical Yields, Rohit Tanaji Dhamdere

Graduate Theses and Dissertations

A bio-refinery is a facility that converts renewable bio-resources into value-added chemicals and products. In this context of a bio-refinery, the production of the carbochemicals such as HMF, furfural and organic acids illustrate that multiple products can be produced from a renewable source such as lignocellulosic biomass (switchgrass). Traditionally, carbochemicals such as furfural and HMF are produced using inorganic acids such as H2SO4, HCL, and H3PO4. The use of such acids requires the application of high cost materials of construction such as Hastelloy-C, titanium etc.

The objective of this study is to develop a semi-continuous process for the conversion of …

Fabrication And Characterization Of Thinner Solid-State Nanopores, Denis Forbi Tita

Graduate Theses and Dissertations

Solid State nanopores that are fabricated by the ion beam sculpting process and electron beam drilling have shown great promise as a sensing device for DNA and protein molecules. Even though biological pores such as the alpha-Haemolysin have been in use for quite some time, the use of solid state Nanopores in single biomolecule detection has been on the rise since the mid 1990s. Solid State nanopores have an advantage over biological pores in that they are more robust, stable, and can be sculpted to any desired size for use in translocation experiments. One of the major challenges in Nanopore …

Ais-Based Coordinated And Adaptive Control Of Generator Excitation Systems For An Electric Ship, Chuan Yan, Ganesh Kumar Venayagamoorthy, Keith Corzine

Electrical and Computer Engineering Faculty Research & Creative Works

An artificial immune system (AIS)-Based control of generator excitation systems for the U.S. Navy's electric ship is presented in this paper to solve power quality problems caused by high-energy loads such as direct energy weapons. the coordinated development of the AIS controllers mainly consists of two parts innate immunity (optimal) and adaptive immunity. the parameters of the controllers for the former, to provide optimal performance, are determined simultaneously using particle swarm optimization. for dramatic changes in the ship's power system, adaptive control based on the immune system feedback law is developed. the feedback law adapts the controllers' parameters only during …

Ambient Habitat Noise And Vibration At The Georgia Aquarium, Peter M. Scheifele, Michael T. Johnson, Laura W. Kretschmer, John G. Clark, D. Kemper, G. Potty

Electrical and Computer Engineering Faculty Research and Publications

Underwater and in-air noise evaluations were completed in performance pool systems at Georgia Aquarium under normal operating conditions and with performance sound tracks playing. Ambient sound pressure levels at in-pool locations, with corresponding vibration measures from life support system (LSS) pumps, were measured in operating configurations, from shut down to full operation. Results indicate noise levels in the low frequency ranges below 100 Hz were the highest produced by the LSS relative to species hearing thresholds. The LSS had an acoustic impact of about 10 dB at frequencies up to 700 Hz, with a 20 dB re 1 μPa impact …

Adsorption Kinetics Of Pb(Ii) And Zn(Ii) Ions Unto Carbonized Groundnut Shells And Maize Cobs, Leke Luter, Aboi Julius, Henry T. Dekaa, B. A. Ikyenge, Ande Sesugh, Monday Uchenna Okoronkwo

Chemical and Biochemical Engineering Faculty Research & Creative Works

Maize cobs and groundnut shell adsorbents from agricultural by-products were carbonized and investigated for adsorption of two selected metals, Lead (Pb II) and Zinc (Zn II) from aqueous solutions of these metals. Kinetic studies of the adsorption processes were investigated employing Elovich and the intraparticle diffussion models. The results showed that, the adsorption capacities of these comparatively cheaper adsorbents and their efficiency for the removal of Pb(II) and Zn(II) ions from aqueous solution present them suitable for use in place of the costly commercial activated carbons.

Understanding The In Vivo Uptake Kinetics Of A Phosphatidylethanolamine-Binding Agent 99mTc-Duramycin, Said H. Audi, Zhixin Li, Joseph Capacete, Yu Liu, Wei Fang, Laura G. Shu, Ming Zhao

Biomedical Engineering Faculty Research and Publications

Introduction

^99mTc-Duramycin is a peptide-based molecular probe that binds specifically to phosphatidylethanolamine (PE). The goal was to characterize the kinetics of molecular interactions between ^99mTc-Duramycin and the target tissue.

Methods

High level of accessible PE is induced in cardiac tissues by myocardial ischemia (30 min) and reperfusion (120 min) in Sprague–Dawley rats. Target binding and biodistribution of ^99mTc-duramycin were captured using SPECT/CT. To quantify the binding kinetics, the presence of radioactivity in ischemic versus normal cardiac tissues was measured by gamma counting at 3, 10, 20, 60 and 180 min after injection. A partially inactivated form of …

Upper Extremity Biomechanical Model For Evaluation Of Pediatric Joint Demands During Wheelchair Mobility, Alyssa J. Paul, Brooke A. Slavens, Adam Graf, Joseph Krzak, Lawrence Vogel, Gerald F. Harris

Biomedical Engineering Faculty Research and Publications

Current methods for evaluating upper extremity (UE) dynamics during pediatric wheelchair use are limited. We propose a new model to characterize UE joint kinematics and kinetics during pediatric wheelchair mobility. The bilateral model is comprised of the thorax, clavicle, scapula, upper arm, forearm, and hand segments. The modeled joints include: sternoclavicular, acromioclavicular, glenohumeral, elbow and wrist. The model is complete and is currently undergoing pilot studies for clinical application. Results may provide considerable quantitative insight into pediatric UE joint dynamics to improve wheelchair prescription, training and long term care of children with orthopaedic disabilities.

Gallium Containing Glass Polyalkenoate Anti-Cancerous Bone Cements: Glass Characterization And Physical Properties, A. W. Wren, A. Coughlan, L. Placek, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

A gallium (Ga) glass series (0.48SiO₂-0.40ZnO-0.12CaO, with 0.08 mol% substitution for ZnO) was developed to formulate a Ga-containing Glass Polyalkenoate Cement (GPC) series. Network connectivity (NC) and X-ray Photoelectron Spectroscopy (XPS) was employed to investigate the role of Ga³⁺ in the glass, where it is assumed to act as a network modifier. Ga-GPC series was formulated with E9 and E11 polyacrylic acid (PAA) at 50, 55 and 60 wt% additions. E11 working times (T_w) ranged from 68 to 96 s (Lcon.) and 106 s for the Ga-GPCs (LGa-1 and LGa-2). Setting times (T_s) …

Enzyme Actuated Bioresponsive Hydrogels, Andrew Wilson

All Theses

Bioresponsive hydrogels are emerging with technological significance in targeted drug delivery, biosensors and regenerative medicine. Conferred with the ability to respond to specific biologically derived stimuli, the design challenge is in effectively linking the conferred biospecificity with an engineered response tailored to the needs of a particular application. Moreover, the fundamental phenomena governing the response must support an appropriate dynamic range and limit of detection. The design of these systems is inherently complicated due to the high interdependency of the governing phenomena that guide the sensing, transduction, and the actuation response of hydrogels. To investigate the dynamics of these materials, …

Development And Characterization Of Shellac-Hydroxypropyl Methyl Cellulose Composite Films With Acid Catalyst, Sana Asrar

All Theses

The objective of this research was to develop a shellac-hydroproyl methyl cellulose (Sh-HPMC) composite film with enhanced water vapor barrier. Citric acid (CA) was used as an acid catalyst, to promote miscibility between HPMC and shellac. In a preliminary test, three different concentrations of CA (1000:1, 200:1, 100:1) were tested to identify the best Sh:CA ratio. Based on the Water vapor permeability properties and mechanical properties, Sh-CA (1000:1 ratio) had the most enhanced water vapor barrier and the lowest reduction in tensile strength compared to the pure HPMC film (control). In the later part of the research, the effect of …

Stabilization Of Extracellular Matrix Components In Bioprosthetic Heart Valves Using Neomycin And Pentagalloyl Glucose Enhanced Crosslinking, Daniel Tripi

All Theses

Bioprosthetic heart valves (BHVs) fail within 12-15 years of implantation due to limited durability. This limits their application to elderly population. Younger patients with contraindications for long-term anticoagulant therapy necessary for mechanical heart valves may also receive BHVs. Investigation into improving valve durability can lead to longer implant life, increased quality of life for patients receiving BHVs, and a broadened patient demographic.
Current BHVs are chemically treated with glutaraldehyde (GLUT) to stabilize collagen via chemical crosslinking and to reduce tissue antigenicity. GLUT fails to adequately stabilize elastin and glycosaminoglycans (GAGs), essential extracellular matrix components for valve function and durability. Degradation …

Continuum Limbed Robots For Locomotion, Alper Mutlu

All Theses

This thesis focuses on continuum robots based on pneumatic muscle technology. We introduce a novel approach to use these muscles as limbs of lightweight legged robots. The flexibility of the continuum legs of these robots offers the potential to perform some duties that are not possible with classical rigid-link robots. Potential applications are as space robots in low gravity, and as cave explorer robots.
The thesis covers the fabrication process of continuum pneumatic muscles and limbs. It also provides some new experimental data on this technology. Afterwards, the designs of two different novel continuum robots - one tripod, one quadruped …