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Thermo-Chemical Conversion Of Coal-Biomass Blends: Kinetics Modeling Of Pyrolysis, Moving Bed Gasification And Stable Carbon Isotope Analysis, Abhijit Bhagavatula

Theses and Dissertations--Chemical and Materials Engineering

The past few years have seen an upsurge in the use of renewable biomass as a source of energy due to growing concerns over greenhouse gas emissions caused by the combustion of fossil fuels and the need for energy independence due to depleting fossil fuel resources. Although coal will continue to be a major source of energy for many years, there is still great interest in replacing part of the coal used in energy generation with renewable biomass. Combustion converts inherent chemical energy of carbonaceous feedstock to only thermal energy. On the other hand, partial oxidation processes like gasification convert …

Addressing Public Health Risks Of Persistent Pollutants Through Nutritional Modulation And Biomimetic Nanocomposite Remediation Platforms, Bradley J. Newsome

Theses and Dissertations--Chemistry

Due to their relative chemical stability and ubiquity in the environment, chlorinated organic contaminants such as polychlorinated biphenyls (PCBs) pose significant health risks and enduring remediation challenges. Engineered nanoparticles (NPs) provide a novel platform for sensing/remediation of these toxicants, in addition to the growing use of NPs in many industrial and biomedical applications, but there remains concern for their potential long-term health effects. Research highlighted herein also represents a transdisciplinary approach to address human health challenges associated with exposure to PCBs and NPs. The objectives of this dissertation research are two-fold, 1) to develop effective methods for capture/sensing and remediation …

Agen/Bsen 344: Biological And Environmental Transport Processes—A Peer Review Of Teaching Project Benchmark Portfolio, Shadi F. Othman

UNL Faculty Course Portfolios

The course I am providing a portfolio for is BSEN/AGEN 344 which is a required course for all our undergraduate students. The Department provides an assessment for the course to align itself with the ABET's Accreditation Process. I taught the course in Spring 2012 adapting a new Team Based Learning Approach. I have three main objective from my portfolio: (1) refine my methods in documenting the linkage between my course goals and assessment measures, (2) document the efficacy of team based learning approach, (3) refine team based learning approach for the current course and adapt the approach to future courses, …

Implementing Green Roofs On Movie Theaters And Shopping Centers: Business Cases In Profitable Sustainability, Ryan J. Miller

Pomona Senior Theses

This thesis presents the business case for installing green roofs on movie theaters and shopping centers. These businesses can then derive increased profits from the environmental benefits of reduced energy use and increased stormwater retention. After presenting the basic design and benefits of a green roof, the thesis develops stand-alone business plans for a movie theater and shopping center. The author finds that green roofs are a profitable sustainability solution for the commercial enterprise.

A Human-Centric Approach To Data Fusion In Post-Disaster Managment: The Development Of A Fuzzy Set Theory Based Model, Mubarak Banisakher

Electronic Theses and Dissertations

It is critical to provide an efficient and accurate information system in the post-disaster phase for individuals' in order to access and obtain the necessary resources in a timely manner; but current map based post-disaster management systems provide all emergency resource lists without filtering them which usually leads to high levels of energy consumed in calculation. Also an effective post-disaster management system (PDMS) will result in distribution of all emergency resources such as, hospital, storage and transportation much more reasonably and be more beneficial to the individuals in the post disaster period. In this Dissertation, firstly, semi-supervised learning (SSL) based …

Prepulse Inhibition Of The Acoustic Startle Reflex: Comparing Low And High Trait Anxious Individuals, Krista Sturm

Honors Theses

This investigation examined whether prepulse inhibition of the acoustic startle reflex was impaired among individuals with high trait anxiety compared to controls. PPI has traditionally been theorized to be a psychophysiological index of information processing and sensorimotor gating, and is now being used to help identify various psychological disorders. Although results of existing research on reduced PPI across the anxiety spectrum are equivocal, previous findings indicate that highly anxious (HA) participants exhibit significantly reduced PPI at lead intervals of 60 ms relative to low anxious (LA) controls. This study paired a 70 dB (A) white noise prepulse stimulus with a …

The Cooling Effect Of Cryotherapy On Power And Accuracy In The Pitching Arms Of Baseball Players, David Kimble Wilbanks

Honors Theses

As the human body does work, energy is released in the form of heat. The ability to perform the same action repeatedly and at the same intensity requires energy to be maintained. By preserving energy in sports, a reduction of injuries and an increase in performance duration would most likely be observed. More specifically in sports, for 200 years of baseball history, the pitcher has attempted to keep their arm warm during resting intervals of a game, in belief this would help sustain their level of performance. This study attempted to overturn this view. I hypothesized that by cooling their …

Chloramination And Corrosion: Case Studies, Utility Experience, And Statistical Comparisons With Chlorination, Jason Heberling

All ETDs from UAB

The United States Environmental Protection Agency (EPA) began implementing the Stage 2 Disinfectant By-products (DBP) Rule (Stage 2) in 2012. The purpose of this regulation is to protect water utility customers from potentially harmful DBP's, most importantly, total trihalomethanes (TTHM) and haloacetic acids (HAA). DBP's have been directly linked to health problems, especially bladder cancer. Regulated DBP's are formed by the chemical reaction of chlorine and naturally occurring organic matter. Chloramines do not produce TTHM's and HAA's and water utilities have used chloramines in place of chlorine in an attempt to meet Stage 2 rules. However, a possible problem of …

Sex Differences In Ss-Adrenergic Responsiveness Of Isolated Rabbit Hearts, Gregory Hoeker

All ETDs from UAB

Stimulation of adrenergic receptors by catecholamines is the predominant regulatory mechanism for cardiovascular performance. Many cardiovascular diseases involve changes in ß-adrenergic signaling that often lead to decreased cardiac performance, cardiac arrhythmias, and/or sudden cardiac death. This has made ß-adrenergic receptors (ß-ARs) a significant therapeutic target in cardiovascular disease. Sex differences in ß-adrenergic responsiveness have been associated with cardioprotection in females, conferring a survival benefit in female patients with heart failure (HF). The heart contains three distinct ß-ARs: ß1-, ß2-, and ß3-AR. It is not known how each ß-AR subtype contributes to the sex differences in ß-responsiveness, let alone how this …

Development Of A High-Throughput Self-Interaction Chromatography System, David Johnson

All ETDs from UAB

The first recombinant human protein drug, insulin expressed in e.coli cells, was approved by the FDA in 1982. Since then, protein therapeutics have become the fastest growing segment of the pharmaceutical industry and include immunoglobulin-g (IgG) directed cancer and immune disorder treatments. A major difficulty to bring protein drugs to market is the requirement that they be concentrated up to 150 mg/ml without aggregation for efficacy in a small injection volume. One way to improve protein drug solubility is to include additives that reduce protein-protein attraction and increase protein-protein repulsion thereby preventing protein molecules from coming together to form aggregates. …

Development Of An Axonal Outgrowth Assessment Methodology For Dorsal Root Ganglia Explants And Demonstration Of Method Efficacy On Electrospun Polymer Scaffolds, Sarah Margaret Kezar

All ETDs from UAB

In chronic spinal cord injury (SCI), a glial encapsulated cyst develops at the injury site and acts as a physical and biochemical barrier to regeneration. Discussion has suggested that filling the cyst with a growth promoting scaffold is a promising approach to cure chronic SCI, though the research to date lacks a systematic approach. Dorsal root ganglia (DRG) explants are an extremely common tissue culture model of neural regeneration employed in this field, however there is no uniform method for objectively quantifying substrate biocompatibility and neurite outgrowth. Therefore, we aimed to develop a novel DRG growth assessment methodology and to …

A Low-Power Multichannel Telemetry System For High-Speed Wireless Neural Recordings, Yang-Guo Li

All ETDs from UAB

The advances in microelectronics and wireless communication are going to change our lifestyles and benefit our healthcare system in the foreseeable future. New conception named "Ubiquitous Healthcare" has been proposed. It envisions a continuous, real-time, remote monitoring on the health conditions of people through the wireless communication network. Traditional biosignal monitoring devices need wire-connections for the recording, which may cause skin rupture and body infection. The physical connections also limited the number of the integrated recording channels. A low-power implantable multichannel telemetry system which can be implanted in the body and transmit recordings wirelessly can solve the problem of the …

Bio-Hybrid Tubular Electrospun Scaffold For Vascular Tissue Engineering Application, Harsh Narendrakumar Patel

All ETDs from UAB

Atherosclerosis is an asymmetric thickening of the intima (innermost layer) of the artery due to plaque (a combination of lipids, debris, connective tissue elements and cells) build up causing the artery to become narrower and stiffer, resulting in a major hemodynamic disturbance[1, 2]. When atherosclerosis affects coronary arteries and prevents blood flow to the heart muscles posing a threat of, or a actual myocardial infarction, that condition is identified as coronary artery disease (CAD). To treat severely blocked coronary arteries,coronary artery bypass grafts (CABG) have became the gold standard for when angioplasty and stent placement has failed to unclog the …

Nanodiamond Mediated Therapies For Prostate Cancer, Amanee Salaam

All ETDs from UAB

Enhancing therapeutic efficacy is essential for successful treatment of chemoresistant cancers such as metastatic hormone-refractory prostate cancer. Current chemotherapy regimens are plagued with issues such as toxicity, low bioavailability, and lack of specificity. To combat these issues, the feasibility of using nanodiamond particles (ND) to enhance the therapeutic efficacy of doxorubicin and resveratrol was investigated. The enhancement of chemotherapy using NDs was evaluated with three unique approaches: (1) drug mediation, (2) combination therapy, and (3) targeted drug delivery. The ND mediated doxorubicin system achieved a 50% improvement in therapeutic efficacy with over 60% cell death. The ND resveratrol combination therapy …

Exploring Intrinsic Biomarkers For Optical Assessment Of Outer Retina, Rongwen Lu

All ETDs from UAB

The retina suffers pathological changes after attacked by eye diseases. The objective of my PhD dissertation is to explore intrinsic biomarkers for noninvasive assessment of retinal morphological structure and physiological function. Fundus autofluorescence (FAF), optical coherence tomography (OCT), etc. have provided indispensable information for eye disease detection. However, better understanding of the intrinsic biomarkers in FAF and OCT is desirable for quantitative interpretation of clinical outcomes. The first specific aim of the dissertation research was to characterize FAF signals across the whole retinal depth using two-photon excitation. FAF signals are usually attributable to fluorophores from the choroidal vessel and the …

Modeling Of Pollutant Transport In The Nile Delta, Egypt, Mohamed Khaled Elsayed Mostafa

All ETDs from UAB

Poor water quality is one of the biggest problems faced by most countries and especially by developing countries such as Egypt. The mismanagement of potable water resources constitutes one of the main reasons for the depletion of water. This research was carried out in the Nile River delta, a region in which toxic dumping and water quality degradation exist. The Nile delta receives pollution loads from industrial, agricultural, and domestic activities located along its path leading to the spread of water-related diseases such as hepatitis, typhoid, cholera, and kidney failure [Safe Drinking Water Foundation, 2009]. The main objective of this …

Quantum Computation Approach To Information Theoretic Modeling And Analysis Of Systems, Luai Najim

All ETDs from UAB

The modeling of systems has been addressed in the physical sciences from the perspective of Energy and matter. The 3rd original idea of Communication as a means of modeling systems has been established and applied. In this study, we apply the 3rd original idea of communication to systems on a quantum level. By marrying Shannon's noisy communication channel to Feynman QED and Quantum Computing, we realize a visual model for the representation of the entropy of a noisy communication channel on a quantum scale. We also use that visual representation concept to define a geometric view into the superposition of …

High Spatiotemporal Resolution Mapping Of Retinal Physiology, Qiuxiang Zhang

All ETDs from UAB

The objective of my PhD dissertation research is to explore high resolution imaging of retinal function using transient intrinsic optical signals (IOSs) correlated with retinal physiological activation. The retina is responsible for capturing photons and preliminary visual information processing. Functional examination of retinal neural cells is important for eye disease detection and treatment evaluation. It is known that different diseases can target different retinal cell types, and thus high resolution imaging of retinal function is desirable. Fast IOSs with time courses comparable to retinal electroretinogram (ERG) kinetics can act as a unique biomarker to map physiological distortions correlated with eye …

Corrosion Prevention And Control Training In An Immersive Virtual Learning Environment, Rustin Deane Webster

All ETDs from UAB

The majority of military education and training has not veered far from the days of chalk and talk instruction. Often with technological breakthroughs comes the proposal of the next revolution in multimedia instruction. Motion pictures to radios to educational television programs have all seemed to come and gone. The next wave of multimedia learning may involve more than a PowerPoint® presentation and lecture. Researchers continue to propose that Virtual Reality (VR) will find its true application and/or market in education and training. The objective of the project was to develop and provide a low-cost, scalable, and portable VR system containing …

Fatigue Testing Of Straight And Angled Abutments In A High Torque Dental Implant System, Rana M. Atieh

All ETDs from UAB

Root form dental implants are a common solution used today to replace missing teeth. However current designs still suffer from a number of limitations. Angled abutments are used for incisors, where maximum human bite forces are normally < 200N, while straight abutments are used for molars subjected to higher forces > 200 N. The aim of this study was to evaluate the mechanical performance of a novel dental implant system by fatigue testing straight and 15-degree angled abutments. It was hypothesized that the novel thread design will dissipate the load evenly throughout the implant allowing the system to withstand normal chewing forces. Implants with 4.2mm diameter were tested according to ISO 14801 in specimen …

Development Of A Concept Exploration Based Teaching Methodology For Undergraduate Chemistry Education, Nicole D. Gray

All ETDs from UAB

Science in general has traditionally been noted as a difficult subject because of its specialized language, mathematical and abstract concepts, and the amount of content to be learned in a semester. In particular, students are believed to base their attitudes towards science-related disciplines on their perceived abilities in understanding or succeeding in a course. Other factors may also contribute to this lack of interest, such as students' metacognitive skills. Concept mapping and computer-aided tools may be used to assist students in building hierarchical knowledge bases that allow them to visually represent connections between concepts. Therefore, the purpose of this study …

Imaging Biomarkers For Prediction Of Treatment Response In Schizophrenia, Jennifer Ann Hadley

All ETDs from UAB

Schizophrenia affects approximately 1% of the population and is one of the top five causes of disability worldwide. Patient response to any particular drug is variable and currently unpredictable. Our overall goal is to identify imaging biomarkers that will distinguish patients with schizophrenia who will respond to an antipsychotic drug from those who will not. When considering potential biomarkers, it is important to note that schizophrenia is known to involve altered neuronal connections, thought to reflect pathologically relevant changes associated with the disease. We propose to utilize functional connectivity as a biomarker for treatment response to antipsychotic drugs in schizophrenia. …

Inkjet Bioprinting Of Solid Peroxides For Constructing Oxygen Generating Scaffolds To Improve Cells Viability And Growth Under Hypoxic Environment, Daniel Reyna Soriano

Open Access Theses & Dissertations

Tissue engineering has emerged as an interdisciplinary field to overcome current challenges for tissue repair or replacement in the human body. In essence, it proposes new medical therapies customized to match the biology of specific patients. The potential benefits offered by tissue engineering have driven scientific inquiry to make it a clinical reality.

One of the current challenges in tissue engineering is to provide oxygen supply to thick tissues as oxygen diffusion is limited to 100 - 200 µm layer of viable tissue. Engineered vascular conduits are applied in vitro, providing pre-vascularization to tissues; however, host anastomosis is still a …

Numerical Prediction Of Collection Efficiency Of A Personal Sampler Based On Cyclone Principle, Antara Badhan

Open Access Theses & Dissertations

A personal bioaerosol sampler is a self-contained, operation flexible, high-efficient device for indoor air quality (IAQ) and health risk exposure monitoring and measurement. Bio-aerosols such germ-laden viruses, microbial species, airborne microorganisms and volatile organic compounds (VOC) are sucked into the sampler and are deposited on the inner wall surface based on cyclone principal. The major concern with bio-aerosol samplers is the collection efficiency. In this study, we used computational fluid dynamics (CFD) tools to evaluate key design parameters, specifically the inlet tube angle and collection tube inner wall roughness. 3D incompressible turbulent flow was simulated using commercial software ANSYS FLUENT. …

Gas-Solid Bed Hydrodynamics Of Non-Spherical Particles, A S M Raufur Rahim Chowdhury

Open Access Theses & Dissertations

Gas-solid beds are ubiquitous in industrial and energy production applications. Examples include fluidized beds, which are used in many systems such as in Integrated Gasification Combined Cycle (IGCC) power plants or in chemical looping systems. These examples and others involve complicated interactions between each phase of reactants in the system. The motivation of this work stems from the need for a better understanding of bed hydrodynamics in existing energy systems; results from this work can be used directly in software such as Fluent to more accurately predict flow behaviors of gas and solid phases. The experimental data are collected from …

Water Resources Systems Analysis: A Bright Past And Challenging But Promising Future, David E. Rosenberg, Kaveh Madani

Civil and Environmental Engineering Faculty Publications

The field of water resources systems analysis is now experiencing one of its most exciting eras where scientists, decision makers, and funding agencies want to apply systems approaches to solve varied, complex, uncertain, and interdisciplinary resource management problems. Solving these problems presents great opportunities for us to engage in complex, real-world decision-making and make positive changes. However, to capitalize on these opportunities, we as a field must also overcome several large challenges related to problem identification, integration, blind use of systems tools, a focus on optimality, and harnessing big data. To overcome, we must look back to find what we …

Novel Conditioning Protocols Focusing On Oxygen Manipulation To Enhance Stem Cell Transplantation, Brandon William Hanna

Theses and Dissertations

Musculoskeletal tissue engineering involves the creation of multiple tissue types that interact together to form a particular function related to motion and maintaining the body's frame. In order to create a fully functional musculoskeletal system, a concrete method for the creation of the different tissue types must first be completed. Of the different tissue components related to the function of a musculoskeletal system, these studies deal with preconditioning circumstances of stem cells that will differentiate into cartilage and bone. These studies also deal with methods for the creation of functional bone and cartilage to be combined for the creation of …

Evaluation Of Tissue-Engineered Tendon Enthesis Polymer Constructs, Joshua A. Bundy Bs, Mary Beth Wade Phd, Hitomi Nakao Md, Phillip Mcclellan Phd, Qing Yu Phd, Robin Jacquet-Childs Ms, William J. Landis Phd

Williams Honors College, Honors Research Projects

Both scientists and clinicians have proposed tissue engineering as the future of medicine. The possibilities for tissue engineering, that is, fabrication of tissues and organs in the laboratory and their translation to patients, appear to be endless, and many believe that this new approach in medicine will result in abolishing many common ailments, injuries, and congenital defects. Injuries to a tendon enthesis, the normal tissue connection between tendon and bone, are of particular concern to clinicians because of their frequency and failure to repair as a result of surgery. While these injuries may not be life threatening, they can certainly …

Visible-Light Photocatalyzed Cross-Linking Of Diacetylene Ligands By Quantum Dots To Improve Their Aqueous Colloidal Stability, Marion G. Götz, Hiroko Takeuchi, Matthew J. Goldfogel, Julia M. Warren, Brandon D. Fennel, Colin D. Heyes

Chemistry & Biochemistry Faculty Publications and Presentations

Ligand cross-linking is known to improve the colloidal stability of nanoparticles, particularly in aqueous solutions. However, most cross-linking is performed chemically, in which it is difficult to limit interparticle cross-linking, unless performed at low concentrations. Photochemical cross-linking is a promising approach but usually requires ultraviolet (UV) light to initiate. Using such high-energy photons can be harmful to systems in which the ligand–nanoparticle bond is fairly weak, as is the case for the commonly used semiconductor quantum dots (QDs). Here, we introduce a novel approach to cross-link thiolated ligands on QDs by utilizing the photocatalytic activity of QDs upon absorbing visible …

Simultaneous Robotic Manipulation And Functional Magnetic Resonance Imaging: Feasibility In Children With Autism Spectrum Disorders, Nicole M.G. Salowitz, Bridget Dolan, Rheanna Remmel, Amy V. Van Hecke, Kristine M. Mosier, Lucia Simo, Robert A. Scheidt

Biomedical Engineering Faculty Research and Publications

An unanswered question concerning the neural basis of autism spectrum disorders (ASD) is how sensorimotor deficits in individuals with ASD are related to abnormalities of brain function. We previously described a robotic joystick and video game system that allows us to record functional magnetic resonance images (FMRI) while adult humans make goal-directed wrist motions. We anticipated several challenges in extending this approach to studying goal-directed behaviors in children with ASD and in typically developing (TYP) children. In particular we were concerned that children with autism may express increased levels of anxiety as compared to typically developing children due to the …