Digital Commons Network^™

Blast Tube Design: How Shape And Size Influence The Resultant Shock Wave, R. L. Bauer, C. E. Johnson

Mining Engineering Faculty Research & Creative Works

Shock tubes and tunnels are often used in research settings as a way of producing high pressure shock waves in a smaller footprint or without the use of explosives. However, there is no standard geometric design across laboratories. Peak pressure is a significant parameter for characterizing a shock wave. However, different tube configurations could also affect parameters such as impulse and duration, yet no research has investigated how the scale of the tube affects the overall waveform shape. To understand the implications of shock tube design, tubes with a constant length to diameter ratio were evaluated to determine how tube …

Uav-Based Phytoforensics: Hyperspectral Image Analysis To Remotely Detect Explosives Using Maize (Zea Mays), Paul V. Manley, Stephen M. Via, Joel G. Burken

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Remnant explosive devices are a deadly nuisance to both military personnel and civilians. Traditional mine detection and clearing is dangerous, time-consuming, and expensive. And routine production and testing of explosives can create groundwater contamination issues. Remote detection methods could be rapidly deployed in vegetated areas containing explosives as they are known to cause stress in vegetation that is detectable with hyperspectral sensors. Hyperspectral imagery was employed in a mesocosm study comparing stress from a natural source (drought) to that of plants exposed to two different concentrations of Royal Demolition Explosive (RDX; 250 mg kg−1, 500 mg kg−1). Classification was accomplished …

Potential Effects Of Statistical Complexity Measure In Improving The Fault Diagnosis Performance Under Speed Fluctuations, S. Sowmya, M. Saimurugan, N. Kannan, Immanuel A. Edinbarough

Informatics and Engineering Systems Faculty Publications

Many research studies are performed in extracting non-stationary signal properties such as instantaneous frequency (IF) and envelope to diagnose machinery faults under time-varying speed conditions. But accurate IF extraction is difficult from such complex fluctuating signals to identify the faults efficiently. Therefore, this paper proposes the Statistical Complexity Measure (SCM) as a feature that evaluates the randomness and complexity without any additional requirement, providing an outstanding result in multi-component fault detection under speed fluctuations. Primarily, the influence of SCM is proved by ranking the features with the help of the Random Forest (RF) algorithm. The fault classification of individual signal …

Ischemia/Reperfusion Injury Enhances Accumulation Of Perfluoropropane Droplets, C. Chen, S. Li, T. O. Matsunaga, E. Carr Everbach, F. Xie, T. R. Porter, F. S. Villanueva, X. Chen

Engineering Faculty Works

Objective: Perfluoropropane droplets (PD) are nanometer-sized particles that can be formulated from commercially available contrast agents. The preferential retention of PDs in diseased microvascular beds can be detected by ultrasound imaging techniques after acoustic activation and offers an opportunity for the detection of such processes as scar formation or inflammation. We hypothesized that in the presence of ischemia/reperfusion (I/R) injury, retention of intravenously injected PDs would be enhanced. Methods: Using an established intravital microscopy model of rat cremaster microcirculation, we determined the retention and subsequent acoustic activation behavior of PDs in exteriorized rat cremaster tissue. DiI-labeled droplets (200 µL) were …

Membrane Filtration Of Nanoscale Biomaterials: Model System And Membrane Performance Evaluation For Aav2 Viral Vector Clarification And Recovery, Mara Leach, Kearstin Edmonds, Emily Ingram, Rebecca Dutch, Sumith R. Wickramasinghe, Malgorzata Chwatko, Dibakar Bhattacharyya

Chemical Engineering Faculty Publications and Presentations

The growing demand for viral vectors as nanoscale therapeutic agents in gene therapy necessitates efficient and scalable purification methods. This study examined the role of nanoscale biomaterials in optimizing viral vector clarification through a model system mimicking real AAV2 crude harvest material. Using lysed HEK293 cells and silica nanoparticles (20 nm) as surrogates for AAV2 crude harvest, we evaluated primary (depth filters) and secondary (membrane-based) filtration processes under different process parameters and solution conditions. These filtration systems were then assessed for their ability to recover nanoscale viral vectors while reducing DNA (without the need for endonuclease treatment), protein, and turbidity. …

Characterizing Phosphorus Removal And Recovery Performance Of A 3d Printed Iron-Embedded Polylactic Acid Composite, Colin B. Wilson, Anthony J. Parolari, Andrew Hiestand, Brooke K. Mayer, Allison Murray

Civil and Environmental Engineering Faculty Research and Publications

Green infrastructure (GI) has been heralded as a solution for reducing phosphorus (P) pollution through increasing stormwater runoff infiltration and improving water quality. Despite its global implementation, GI struggles to improve the effluent water quality discharged from these systems consistently. This research evaluates the P removal performance and recovery potential of iron-embedded polylactic acid (PLA) composites through a novel application of three-dimensional (3D) printed representative unit cells (RUC) that could be used to improve effluent quality in GI. The RUC required chemical oxidation to convert the embedded iron to hematite (Fe₂⁢O₃) to facilitate P adsorption. Batch …

High Shear Stress Reduces Erg Causing Endothelial-Mesenchymal Transition And Pulmonary Arterial Hypertension, Tsutomu Shinohara, Jan-Renier Moonen, Yoon Hong Chun, Yannick C. Lee-Yow, Kenichi Okamura, Jason M. Szafron, Jordan Kaplan, Aiqin Cao, Lingli Wang, Weiguang Yang

Mechanical Engineering Faculty Publications

Background: Computational modeling indicated that pathological high shear stress (HSS; 100 dyn/cm2) is generated in pulmonary arteries (PAs; 100-500 µm) in congenital heart defects causing PA hypertension (PAH) and in idiopathic PAH with occlusive vascular remodeling. Endothelial-to-mesenchymal transition (EndMT) is a feature of PAH. We hypothesize that HSS induces EndMT, contributing to the initiation and progression of PAH.

Methods: We used the Ibidi perfusion system to determine whether HSS applied to human PA endothelial cells (ECs) induces EndMT when compared with physiological laminar shear stress (15 dyn/cm2). The mechanism was investigated and targeted to prevent PAH in a mouse with …

Introduction To The Special Issue On Verification And Validation Of Source And Propagation Models For Underwater Sounda), Kathleen J. Vigness-Raposa, Klaus Lucke, Michael A. Ainslie, Michele B. Halvorsen, Christ A. F. De Jong, Stanley J. Labak, Martin Siderius

Electrical and Computer Engineering Faculty Publications and Presentations

This joint Special Issue of JASA and JASA Express Letters focuses on underwater sound source and propagation modelling, both of ambient sound as well as sources of relevance to possible effects of sound on aquatic life, and corresponding acoustical metrics. Combining information on the sound field with information on a dose-effect relationship enables estimation of the potential effects. The Special Issue presents a collection of eighteen articles on the following topics: (1) verification of source and propagation models, (2) validation of source and propagation models, and (3) bioacoustical metrics for assessment of the risk of environmental effects. This special issue …

Economic Impact Of Energy Accounting Schemes For Commercial Systems On A Broiler Farm With Power Demand And Generation, Yi Liang, Michael Popp

Biological and Agricultural Engineering Faculty Publications and Presentations

The aim of this study was to assess the impact of the on-farm solar photovoltaic (PV) generation to offset grid electricity consumption on a commercial poultry farm in the US. Hourly electricity production by PV systems was estimated using the System Advisor Model (SAM) of the National Renewable Energy Lab (NREL) and compared with the estimated electric load demand of a broiler house. We analyzed the economic benefits of installing solar systems of three capacities under net energy metering and net energy billing pricing scenarios. Results suggested that a smaller PV installation of 35 kWp, while substantially short of meeting …

Environmental-Health Convergence: A Deep Learning-Oriented Decision Support System For Catalyzing Sustainable Healthy Food Systems, Prince Agyemang, Ebenezer M. Kwofie, Jamie I. Baum, Dongyi Wang, Emmanuel A. Kwofie

Biological and Agricultural Engineering Faculty Publications and Presentations

To generate evidence to address food system challenges, we developed an adaptable framework for multimodel assessment of the convergence effect of health and environmental drivers in food systems. We achieved this goal by developing a modeling framework that facilitates testing and applying four deep-learning algorithms using a case study of the United States's food system. Among the models tested, the bidirectional and single-layer long short-term memory models outperformed the others with α_E(2.75) and α_H(3.51) when predicting environmental drivers and health drivers, respectively. All the models tested performed better at predicting environmental than health drivers. The best-performing …

Pilot Study: Initial Investigation Suggests Differences In Emt-Associated Gene Expression In Breast Tumor Regions, Kylie L. King, Hamed Abdollahi, Zoe Dinkel, Alannah Akins, Homayoun Valafar, Heather Dunn

Faculty Publications

Triple negative breast cancer (TNBC) is the most aggressive subtype and disproportionately affects African American women. The development of breast cancer is highly associated with interactions between tumor cells and the extracellular matrix (ECM), and recent research suggests that cellular components of the ECM vary between racial groups. This pilot study aimed to evaluate gene expression in TNBC samples from patients who identified as African American and Caucasian using traditional statistical methods and emerging Machine Learning (ML) approaches. ML enables the analysis of complex datasets and the extraction of useful information from small datasets. We selected four regions of interest …

New Insights Into Controlling The Functional Properties Of Tin Oxide-Based Materials, Alexandra Kuriganova, Nina Smirnova

Journal of Electrochemistry

Development of methodologies for fabrications of nanostructured materials that provide control over their microstructural features and compositions represents a fundamental step in the advancement of technologies for productions of materials with well-defined functional properties. Pulse electrolysis, a top-down electrochemical approach, has been demonstrated to be a viable method for producing nanostructured materials with a particular efficacy in the synthesis of tin oxides. This method allows for significant control over the composition and shape of the resulting tin oxides particles by modifying the anionic composition of the aqueous electrolyte, obviating the need for additional capping agents in the synthesis process and …

A Cnt Intercalated Co Porphyrin-Based Metal Organic Framework Catalyst For Oxygen Reduction Reaction, Pei-Pei He, Jin-Hua Shi, Xiao-Yu Li, Ming-Jie Liu, Zhou Fang, Jing He, Zhong-Jian Li, Xin-Sheng Peng, Qing-Gang He

Journal of Electrochemistry

The poor electronic conductivity of metal-organic framework (MOF) materials hinders their direct application in the field of electrocatalysis in fuel cells. Herein, we proposed a strategy of embedding carbon nanotubes (CNTs) during the growth process of MOF crystals, synthesizing a metalloporphyrin-based MOF catalyst TCPPCo-MOF-CNT with a unique CNT-intercalated MOF structure. Physical characterization revealed that the CNTs enhance the overall conductivity while retaining the original characteristics of the MOF and metalloporphyrin. Simultaneously, the insertion of CNTs generated adequate mesopores and created a hierarchical porous structure that enhances mass transfer efficiency. X-ray photoelectron spectroscopic analysis confirmed that the C atom in CNT …

Nanostructured Graphitic Carbon Nitride For Photocatalytic And Electrochemical Applications, Muhammad Abdul Qadeer, Iqra Fareed, Asif Hussaine, Muhammad Asim Farid, Sadia Nazir, Faheem K. Butt, Ji-Jun Zou, Muhammad Tahir, Shang-Feng Du

Journal of Electrochemistry

Graphitic carbon nitride (g-C₃N₄) exhibits great mechanical as well as thermal characteristics, making it a valuable material for use in photoelectric conversion devices, an accelerator for synthesis of organic compounds, an electrolyte for fuel cell applications or power sources, and a hydrogen storage substance and a fluorescence detector. It is fabricated using different methods, and there is a variety of morphologies and nanostructures such as zero to three dimensions that have been designed for different purposes. There are many reports about g-C₃N₄ in recent years, but a comprehensive review which covers nanostructure dimensions …

Comparison Of Milling Cutting Forces In Synthetic And Biological Cancellous Bone, Matthew Christopher Hartwell

Masters Theses

In many orthopedic and dental interventions, the cutting and removal of bone is necessary. Therefore, it is of the utmost importance that the tools used during these procedures are designed and tested with biological bone or a bone surrogate material that machines the same way as biological bone. To avoid the cost, hazard, and inconsistency of biological cadaveric bone or animal models, many biological engineering firms use bone surrogate material made of glass fiber filled epoxy and polyurethane foam. Although these materials may mimic the elongation of cortical and cancellous bone, respectively, the match of machinability of the bone is …

Proximal Remote Sensing: An Essential Tool For Bridging The Gap Between High-Resolution Ecosystem Monitoring And Global Ecology, Zoe Amie Pierrat, Troy S. Magney, Will P. Richardson, Benjamin R. K. Runkle, Jen L. Diehl, Xi Yang, William Woodgate, William K. Smith, Miriam R. Johnston, Yohanes R. S. Ginting, Gerbrand Koren, Loren P. Albert, Christopher L. Kibler, Bryn E. Morgan, Mallory Barnes, Adriana Uscanga, Charles Devine, Mostafa Javadian, Karem Meza, Tommaso Julitta, Giulia Tagliabue, Matthew P. Dannenberg, Michal Antala, Christopher Y. S. Wong, Andre L. D. Santos, Koen Hufkens, Julia K, Marrs, Atticus E. L. Stovall, Yujie Liu, Joshua B. Fisher, John A. Gamon, Kerry Cawse-Nicholson

Civil and Environmental Engineering Student Research

A new proliferation of optical instruments that can be attached to towers over or within ecosystems, or ‘proximal’ remote sensing, enables a comprehensive characterization of terrestrial ecosystem structure, function, and fluxes of energy, water, and carbon. Proximal remote sensing can bridge the gap between individual plants, site-level eddy-covariance fluxes, and airborne and spaceborne remote sensing by providing continuous data at a high-spatiotemporal resolution. Here, we review recent advances in proximal remote sensing for improving our mechanistic understanding of plant and ecosystem processes, model development, and validation of current and upcoming satellite missions. We provide current best practices for data availability …

Diversity, Equity, And Inclusion In Computing Science: Culture Is The Key, Curriculum Contributes, Giulia Toti, Peggy Lindner, Alice Gao, Ouldooz Baghban Karimi, Rutwa Engineer, Jinyoung Hur, Fiona Mcneill, Shanon Reckinger, Rebecca Robinson, Anna Sollazzo, Richard Wicentowski

Engineering Management and Systems Engineering Faculty Research & Creative Works

Undergraduate computer science programs worldwide struggle to attract and retain underrepresented students for many reasons. Culture, stereotype threats, uneven gender and racial representations, lack of role models, and uncertain career prospects for minority groups are among the many reasons behind this situation. Many computer science programs are trying to change course through strategies to foster equity, diversity, and inclusion (EDI), aimed at improving outreach, recruitment, admissions, and retention of underrepresented students. EDI approaches may also include modifications to the undergraduate computer science curriculum. However, if not properly planned, these modifications risk amplifying existing stereotypes rather than producing positive change [38]. …

Fast 3d Printing Of Fine, Continuous, And Soft Fibers Via Embedded Solvent Exchange, Wonsik Eom, Mohammad Tanver Hossain, Vidush Parasramka, Jeongmin Kim, Ryan W. Y. Siu, Kate A. Sanders, Dakota Piorkowski, Andrew Lowe, Hyun Gi Koh, Michael F. L. De Volder, Douglas S. Fudge, Randy H. Ewoldt, Sameh H. Tawfick

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Nature uses fibrous structures for sensing and structural functions as observed in hairs, whiskers, stereocilia, spider silks, and hagfish slime thread skeins. Here, we demonstrate multi-nozzle printing of 3D hair arrays having freeform trajectories at a very high rate, with fiber diameters as fine as 1.5 µm, continuous lengths reaching tens of centimeters, and a wide range of materials with elastic moduli from 5 MPa to 3500 MPa. This is achieved via 3D printing by rapid solvent exchange in high yield stress micro granular gel, leading to radial solidification of the extruded polymer filament at a rate of 2.33 μm/s. …

Novel Multi-Gait Strategy For Stable And Efficient Quadruped Robot Locomotion, Daoxun Zhang, Xieyuanli Chen, Zhengyu Zhong, Ming Xu, Zhiqiang Zheng, Huimin Lu

Journal of System Simulation

Abstract: Inspired by the natural gait transition mechanism of quadruped animals, a multi-gait motion strategy is proposed to realize the stable and efficient motion of quadruped robots on different terrains in response to the trade-off between motion energy efficiency and motion stability. The gait is defined based on the duty cycle parameters and phase bias to form the switching basis. Secondly, the affine transformation of gait parameters and the finite state machine are introduced to establish the switching sequence, which realizes the timely gait switching. The speed-gait mapping is designed based on the cost of transport (CoT) and the stability …

Research On Path Planning Method For Autonomous Underwater Vehicles Based On Improved Informed Rrt, Bensheng Qi, Yan Li, Hongxia Miao, Jialin Chen, Chenglin Li

Journal of System Simulation

Abstract: In response to the autonomous underwater vehicle (AUV) path planning problem in complex underwater environments, an improved path planning algorithm based on Informed rapidly-exploring random trees (RRT) is proposed in this study. A target-biased sampling strategy and a target-biased extension strategy are employed to address the issue of lack of goal orientation in the sampling process, ensuring that target nodes become sampling points during random sampling. During path points extension, non-target sampling points are guided in the direction of the target point, thereby enhancing the algorithm's ability to search for the target during random sampling and extension processes. A …

The Design And Cell-Free Protein Synthesis Of A Pembrolizumab Single-Chain Variable Fragment, Landon E. Ebbert, Tyler J. Free, Mehran Soltani, Bradley Charles Bundy

Faculty Publications

Background/Objectives: Cancer is a leading cause of death. However, recently developed immunotherapies have shown significant promise to improve cancer treatment outcomes and survival rates. Pembrolizumab, a cancer immunotherapy drug, enables a strong T-cell response specifically targeting cancer cells to improve patient outcomes in more than 16 types of cancer. The increasing demand for pembrolizumab, the highest selling drug in 2023, increases global dependence on drug production, which can be vulnerable to supply chain disruptions. Methods: Cell-free protein synthesis (CFPS) is a rapid in vitro protein production method that could provide the production of an immunotherapy drug in an emergency and …

Municipal Solid Waste Management In Egypt Environmental And Economic Objectives, Nader Ibrahem Ismael

Mansoura Engineering Journal

The research aims to study the problem of municipal solid waste in Egypt, which notes the growth of the phenomenon of dumping this waste in the streets of Egypt, especially following the January 25 revolution and the resulting shortcomings in the performance of successive governments in confronting this problem, which led to an increasing rate of solid waste accumulation in the streets of Cairo and the shortcomings of the administrations’ performance. There is also a lack of a specific methodology for collecting local waste at the republic level. The research aims to develop a methodology for managing these wastes, starting …

Feasibility And Acceptability Of The Mazi Umntanakho Digital Tool In South African Settings: A Qualitative Evaluation, Catherine E. Draper, Caylee J. Cook, Elizabeth A. Ankrah, Jesus A. Beltran, Franceli L. Cibrian, Kimberley D. Lakes, Hanna Mofid, Lucretia Williams, Gillian R. Hayes

Engineering Faculty Articles and Research

To address the need for interventions targeting social emotional development and mental health of young children in South Africa, the Mazi Umntanakho (‘know your child’) digital tool was co-designed, and piloted with caregivers and 3–5-year-old children involved in home visiting programmes promoting early childhood development. The aim of this study was to qualitatively evaluate the feasibility and acceptability of this tool in four urban and four rural low-income communities, from the perspective of home visitors and caregivers. Focus groups were conducted with home visitors (n = 117) and caregivers (n = 72). Issues relating to the feasibility of …

What’S New In Esophageal Atresia Treatment?, Alexandra N. Jimenez Gonzalez

Mako: NSU Undergraduate Student Journal

No abstract provided.

Desktop-Scale Robot Tape Manipulation For Additive Manufacturing, Nahid Tushar, Rencheng Wu, Yu She, Wenchao Zhou, Wan Shou

School of Industrial Engineering Faculty Publications

Advancements in additive manufacturing and robotic automation have enabled diverse fabrication techniques using various materials. However, small-scale tape placement for three-dimensional (3D) printing remains underexplored, with most research focused on large-scale composite manufacturing using carbon fiber prepreg tapes. This work presents an innovative, automated, and cost-effective tape placement system that extends traditional methods beyond carbon fiber prepreg. We developed a customized tape print module (TPM) integrated with a robotic arm, enabling precise and versatile tape placements. Our system supports non-linear toolpaths, complex patterns, and controllable placements on multi-plane surfaces, creating overhangs without support. We demonstrate circuit printing with copper tape …

Modeling Virus Filtration: Materials, Applications, And Mechanism, Hironobu Shiritaki, Linda Gudex, Sumith R. Wickramasinghe

Chemical Engineering Faculty Publications and Presentations

While various methods are employed to ensure the virus safety of finished products, virus filtration (VF) stands out as the preferred method for virus removal and purification of a wide variety of products owing to its capability of separating product molecules with more than 90% recovery and no change in molecule characteristics. The modeling of the virus removal process for VF membranes is based on the principles of microfiltration (MF) and ultrafiltration (UF), but with modifications for the much narrower separation difference, which is less than 2-fold for the separation of product molecules and virus particles. In this review, we …

Dunbar’S Number In Motion: Agent-Based Simulations Of Friendship Formation, Christopher R. Cooke, Cameron D. Lutz

Northeast Journal of Complex Systems (NEJCS)

By contrasting Lévy flight and random walk strategies in simulated agents, we discern the effect of movement behavior on the total duration of social interactions. Our agent-based simulation results approximate empirically observed Dunbar social circle formation using simple behavioral rules of interaction and compatibility to mimic exogenous attribute-based friendship formation. We simulate the complexities of social interactions among agents with unique attributes and a time budget for social engagement over a one-year period. Two distinct simulations were conducted to evaluate the behavioral contributions of Lévy flight and random walk movement patterns on cumulative interaction duration and the formation of Dunbar …

Calcium Phosphate Formation And Deposition In Ischemic Neurons, Shu Q. Liu, John B. Troy, Jeremy Goldman, Roger J. Guillory

Michigan Tech Publications

Ischemic stroke causes acute brain calcium phosphate (CaP) deposition, a process involving primarily the injured neurons. Whereas the adverse impact of CaP deposition on the brain structure and function has been recognized, the underlying mechanisms remain poorly understood. This investigation demonstrated that the neuron-expressed, plasma membrane-associated Ca2+-binding proteins annexin (Anx) A2, AnxA5, AnxA6, and AnxA7 contributed to neuronal CaP deposition in the mouse model of ischemic stroke. These Anxs were released from the degraded plasma membrane of the ischemic neurons and were able to form Anx/CaP complexes, a nanostructure capable of binding to the β actin filaments via Anx–actin interaction …

Connotation, Research Status, And Development Directions Of Clean Coal Geology In China, Tang Yuegang, Wang Shaoqing, Wang Xiaoshuai, Guo Xin, Wang Yafeng, Xue Liping, Harold H. Schobert

Coal Geology & Exploration

Objective The exploration and assessment of low-carbon, zero-emission, and maximized utilization of coal resources, emerge as a focus of coal geology in the 21st century. [Research Advances] Based on the research content of coals and coal geology, along with the domestic and international development trends of clean coal technology (CCT), this study defines clean coal geology in the broad and narrow sense. Clean coal geology in the narrow sense focuses on the geological and geochemical issues related to efficiency enhancement and emission reduction in coal processing and utilization. In contrast, clean coal geology in the broad sense emphasizes …

Associations Between Social Determinants Of Health And Mental Health Disorders Among U.S. Population: A Cross-Sectional Study, S. Tanarsuwongkul

Faculty Publications

Aims

The impact of social determinants of health (SDOH) on mental health is increasingly realized. A comprehensive study examining the associations of SDOH with mental health disorders has yet to be accomplished. This study evaluated the associations between five domains of SDOH and the SDOH summary score and mental health disorders in the United States.

Methods

We analyzed data from a diverse group of participants enrolled in the All of Us research programme, a research programme to gather data from one million people living in the United States, in a cross-sectional design. The primary exposure was SDOH based on Healthy …