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Mathematical Modeling Of Color Perception Using Differential Equation, Siavash Pooretemad Apr 2025

Mathematical Modeling Of Color Perception Using Differential Equation, Siavash Pooretemad

Student Research Symposium

Color perception begins in the retina, where three cone types (L, M, S) detect light and initiate neural signals. These signals are processed by horizontal and bipolar cells to form opponent color channels: red-green (RG), yellow-blue (YB), and light-dark (LD). Perception is not solely based on physical input but also shaped by neural adaptation and context.

This project models color perception using a differential equation approach, simulating how color contrast and adaptation emerge from interactions between photoreceptors and lateral inhibition.

We hypothesize that a system of differential equations can model how retinal cone cells respond to and process light intensity, …


Laparoscopic Articulating Arm: In Collaboration With The Xenocor Saberscope, Zac Hastings, Lizbeth Pugliese, Rebecca Sweeten, Dallin Thomas, Dallin Treasure-Areno Apr 2025

Laparoscopic Articulating Arm: In Collaboration With The Xenocor Saberscope, Zac Hastings, Lizbeth Pugliese, Rebecca Sweeten, Dallin Thomas, Dallin Treasure-Areno

Student Research Symposium

• Laparoscopy a minimally invasive procedure performed through small incisions using a laparoscope, a camera-equipped instrument, along with specialized tools.

• Laparotomy or "open" surgery, requires a large incision to perform an abdominal operation.


Comparative Analysis Of Vertical And Horizontal Subsurface Flow Constructed Wetlands For Eutrophication Mitigation", Ali M. Ahmed Apr 2025

Comparative Analysis Of Vertical And Horizontal Subsurface Flow Constructed Wetlands For Eutrophication Mitigation", Ali M. Ahmed

Al-Bahir

Constructed wetlands (CWs) serve as a sustainable and eco-friendly solution for wastewater treatment, particularly in the removal of eutrophication-causing pollutants. This review focuses on the comparative performance of Vertical Flow (VF) and Horizontal Flow (HF) Subsurface Flow (SSF) systems, assessing their efficiency in removing Biochemical Oxygen Demand (BOD), Chemical Oxygen Demand (COD), Total Nitrogen (TN), and Total Phosphorus (TP). VF systems demonstrate superior pollutant removal, particularly for nitrogen, due to enhanced aeration and efficient oxygenation processes. In addition, their compact design reduces land area requirements, making them advantageous in space-limited applications. Conversely, HF systems are more effective at supporting nutrient …


Aqueous Extracts Of Zingiber Officinale Rhizomes And Hibiscus Sabdariffa Leaves Enhanced Plasmodium Berghei-Infected Mice's Hematological Parameters., Fatimah Aluko Abubakar, Raliat Abimbola Aladodo, Aremu Abubakar Apr 2025

Aqueous Extracts Of Zingiber Officinale Rhizomes And Hibiscus Sabdariffa Leaves Enhanced Plasmodium Berghei-Infected Mice's Hematological Parameters., Fatimah Aluko Abubakar, Raliat Abimbola Aladodo, Aremu Abubakar

Al-Bahir

Malaria remains a global health challenge, leading to severe hematological complications. Natural alternatives such as Zingiber officinale and Hibiscus sabdariffa, known for their antioxidant and bioactive properties, are being investigated for their therapeutic potential. This study examines the hematological benefits of Z. officinale and H. sabdariffa in mice infected with the common malaria research model, NK65 chloroquine-sensitive Plasmodium berghei. Forty-two albino mice, averaging 24.5 ± 1.23g, were randomly divided into six groups. Mice in group A were uninfected which served as the normal control group. Mice in groups B, C, D, E, and F were inoculated intraperitoneally with P. …


Examining Physiological Responses To Misophonic Triggers, Christian O'Reilly, Xuan Yang, Sewon Oh, Doug Wedell, Svetlana Shinkareva Apr 2025

Examining Physiological Responses To Misophonic Triggers, Christian O'Reilly, Xuan Yang, Sewon Oh, Doug Wedell, Svetlana Shinkareva

Faculty Publications

We collected and analyzed an array of biosignals (face electromyogram, skin electrodermal activity, peripheral temperature, and electrocardiogram) in 60 participants with and without misophonia, a condition characterized by decreased tolerance to innocuous sounds. Our goal was to objectively characterize the physiological response to misophonia triggering sounds. We found that misophonic responses can be objectively identified in some cases through atypical physiological reactions to triggering stimuli, though not all participants exhibited this response. Our analyses suggest a large interindividual variability in response to misophonic triggers and highlights the need for methodological adjustments in future experiments to increase the detectability of misophonic …


A Reliable And Efficient Detection Pipeline For Rodent Ultrasonic Vocalizations, Sabah Shahnoor Anis, Devin Mark Kellis, Kris Ford Kaigler, Marlene A. Wilson, Christian O'Reilly Apr 2025

A Reliable And Efficient Detection Pipeline For Rodent Ultrasonic Vocalizations, Sabah Shahnoor Anis, Devin Mark Kellis, Kris Ford Kaigler, Marlene A. Wilson, Christian O'Reilly

Faculty Publications

Analyzing ultrasonic vocalizations (USVs) is crucial for understanding rodents' affective states and social behaviors, but the manual analysis is time-consuming and prone to errors. Automated USV detection systems have been developed to address these challenges. Yet, these systems often rely on machine learning and fail to generalize effectively to new datasets. To tackle these shortcomings, we introduce ContourUSV, an efficient automated system for detecting USVs from audio recordings. Our pipeline includes spectrogram generation, cleaning, pre-processing, contour detection, post-processing, and evaluation against manual annotations. To ensure robustness and reliability, we compared ContourUSV with three state-of-the-art systems using an existing open-access USV …


Metabolite Analysis To Understand Factors Limiting Microbial Fermentation At High Substrate Concentrations, Bishal D. Sharma Apr 2025

Metabolite Analysis To Understand Factors Limiting Microbial Fermentation At High Substrate Concentrations, Bishal D. Sharma

Dartmouth College Ph.D Dissertations

Clostridium thermocellum, a thermophilic anaerobic bacterium, holds promise as a biocatalyst for conversion of lignocellulosic biomass into biofuels. This microbe has been subjected to various metabolic engineering strategies, including the deletion of genes encoding secondary fermentation products such as H₂, formate, acetate, and lactate, as well as the expression of heterologous genes to redirect carbon flux toward ethanol production. Despite these efforts, achieving economically viable ethanol titers remains a challenge. We hypothesized that studying how intracellular metabolite concentrations change as fermentation stops could reveal metabolic bottlenecks or regulatory mechanisms limiting ethanol production at high titers. However, metabolomics studies at …


Exploring Credit Loss For Engineering Transfer Students, Amy J. Richardson, David B. Knight Apr 2025

Exploring Credit Loss For Engineering Transfer Students, Amy J. Richardson, David B. Knight

Inquiry: The Journal of the Virginia Community Colleges

One of the issues at the heart of transfer is the mobility of credits across institutions—moving credits from one institution to another is a crucial process for the transfer pathway to be a viable option. Credit loss is a critical issue for transfer students enrolled in highly sequential degrees, such as engineering. A student could be set back a year or more if they miss one required prerequisite course at the time of transfer. Determining who experiences credit loss in engineering could help ease the transfer process, improve graduation rates, and broaden participation in engineering since the transfer pathway has …


A Neutrosophic Micro Vague Correlation Measure: Application To Multi-Criteria Decision Making Problems, Vargees Vahini T, Trinita Pricilla M Apr 2025

A Neutrosophic Micro Vague Correlation Measure: Application To Multi-Criteria Decision Making Problems, Vargees Vahini T, Trinita Pricilla M

Neutrosophic Systems with Applications

Statistical methods called correlation measures are employed to express the degree of association or relationship between two variables. The correlation coefficient which may be computed in a variety of ways is the most often used kind of correlation measure in many disciplines including biology, psychology, economics, and finance. Knowing the correlations between variables is essential for analysis and decision-making. This paper aims to commence a novel type of correlation measure called Neutrosophic Micro vague Correlation Measure and Neutrosophic Micro Vague Weighted Correlation Measure. Further demonstrates the implementation of the Neutrosophic Micro Vague correlation measure in the MCDM Problem. By adopting …


A Neutrosophic Micro Vague Correlation Measure: Application To Multi-Criteria Decision Making Problems, Vargees Vahini T, Trinita Pricilla M Apr 2025

A Neutrosophic Micro Vague Correlation Measure: Application To Multi-Criteria Decision Making Problems, Vargees Vahini T, Trinita Pricilla M

Neutrosophic Systems with Applications

Statistical methods called correlation measures are employed to express the degree of association or relationship between two variables. The correlation coefficient which may be computed in a variety of ways is the most often used kind of correlation measure in many disciplines including biology, psychology, economics, and finance. Knowing the correlations between variables is essential for analysis and decision-making. This paper aims to commence a novel type of correlation measure called Neutrosophic Micro vague Correlation Measure and Neutrosophic Micro Vague Weighted Correlation Measure. Further demonstrates the implementation of the Neutrosophic Micro Vague correlation measure in the MCDM Problem. By adopting …


Improved Estimator For Population Mean Utilizing Known Medians Of Two Auxiliary Variables Under Neutrosophic Framework, Rajesh Singh, Shobh Nath Tiwari Apr 2025

Improved Estimator For Population Mean Utilizing Known Medians Of Two Auxiliary Variables Under Neutrosophic Framework, Rajesh Singh, Shobh Nath Tiwari

Neutrosophic Systems with Applications

In the context of classical statistics, the estimation of the population mean is done with determinate, precise, and crisp data when auxiliary information is available. However, there are instances where dealing with uncertain, indeterminate, and imprecise data in interval form is required. To overcome this issue, Florentin Smarandache introduced neutrosophic statistics as a novel approach. This paper introduces a neutrosophic modified ratio-cum-product log-type estimator for the estimation of the population mean using known medians of two auxiliary variables in the neutrosophic context. The bias and mean squared error (MSE) for the proposed estimators are computed to the first-order approximation. The …


Some Graph Parameters For Superhypertree-Width And Neutrosophictree-Width, Takaaki Fujita, Florentin Smarandache Apr 2025

Some Graph Parameters For Superhypertree-Width And Neutrosophictree-Width, Takaaki Fujita, Florentin Smarandache

Neutrosophic Systems with Applications

Graph characteristics are often studied through various parameters, with ongoing research dedicated to exploring these aspects. Among these, graph width parameters—such as treewidth—are particularly important due to their practical applications in algorithms and real-world problems. A hypergraph generalizes traditional graph theory by abstracting and extending its concepts [77]. More recently, the concept of a SuperHyperGraph has been introduced as a further generalization of the hypergraph. Neutrosophic logic [133], a mathematical framework, extends classical and fuzzy logic by allowing the simultaneous consideration of truth, indeterminacy, and falsity within an interval. In this paper, we explore Superhypertree-width, Neutrosophic treewidth, and t-Neutrosophic tree-width.


A Reconsideration Of Advanced Concepts In Neutrosophic Graphs: Smart, Zero Divisor, Layered, Weak, Semi, And Chemical Graphs, Takaaki Fujita, Florentin Smarandache Apr 2025

A Reconsideration Of Advanced Concepts In Neutrosophic Graphs: Smart, Zero Divisor, Layered, Weak, Semi, And Chemical Graphs, Takaaki Fujita, Florentin Smarandache

Neutrosophic Systems with Applications

One of the most powerful tools in graph theory is the classification of graphs into distinct classes based on shared properties or structural features. Over time, many graph classes have been introduced, each aimed at capturing specific behaviors or characteristics of a graph. Neutrosophic Set Theory, a method for handling uncertainty, extends fuzzy logic by incorporating degrees of truth, indeterminacy, and falsity. Building on this framework, Neutrosophic Graphs [9, 84, 135] have emerged as significant generalizations of fuzzy graphs. In this paper, we extend several classes of fuzzy graphs to Neutrosophic graphs and analyze their properties.


2024, A Landmark Year For Climate Change And Global Carbon Capture, Utilization, And Storage: Annual Progress Review, Shangli Shi, Yun Hang Hu Apr 2025

2024, A Landmark Year For Climate Change And Global Carbon Capture, Utilization, And Storage: Annual Progress Review, Shangli Shi, Yun Hang Hu

Michigan Tech Publications

This annual review outlines the progress of carbon capture, utilization, and storage (CCUS) technologies in 2024. As human-induced CO2 emissions continued to rise, the year presented critical challenges. Notably, 2024 was the hottest year on record and the first in which global temperatures exceeded preindustrial levels by more than 1.5°C, driving intensified efforts to advance CCUS. Scientific interest in CCUS grew significantly, with the annual number of related publications increasing by 11.4% compared to 2023, reaching 53,970. The total number of operational commercial CCUS facilities also expanded, rising by 16.3% to a total of 50. In the political area, governments …


Workforce Forecasting For State Transportation Agencies: A Machine Learning Approach, Adedolapo Ogungbire, Suman Mitra Apr 2025

Workforce Forecasting For State Transportation Agencies: A Machine Learning Approach, Adedolapo Ogungbire, Suman Mitra

Civil Engineering Faculty Publications and Presentations

A decline in the number of construction engineers and inspectors at state transportation agencies (STAs) to manage the ever-increasing lane miles has emphasized the importance of workforce planning in these agencies. Forecasting workforce requirements is crucial for effective planning in any industry or agency. This study developed machine learning (ML) models to estimate the person-hour requirements of STAs at the project level. The Arkansas Department of Transportation (ARDOT) was used as a case study, using its employee and project details data between 2012 and 2021. ML regression models ranging from linear, tree ensembles, kernel-based, and neural network-based models were …


Determining The Wound Closure Capabilities Of A Biological Engineered Blood Vessel For Hd Access, Brianna Regan, Alex Dumitru, Mai Lam Apr 2025

Determining The Wound Closure Capabilities Of A Biological Engineered Blood Vessel For Hd Access, Brianna Regan, Alex Dumitru, Mai Lam

Medical Student Research Symposium

End stage renal disease (ESRD) is a prominent chronic condition with dialysis as a primary treatment option. Dialysis necessitates implementation of an access point, with the gold standard being an AV fistula which possesses multiple shortcomings. Alternative access points, namely synthetic grafts, do not allow wound healing characteristics. This work aims to explore how a tissue engineered vascular graft (TEVG) may be able to address these issues by allowing a long-term access point for HD that can close puncture wounds.

The effects of growth factors on our cells were tested preliminarily by means of a scratch assay on plates of …


Maldi-Mass Spectrometry Imaging To Investigate Distribution Of Per- And Polyfluoroalkyl Substances In Exposed Poplar Tissues, Tonglin Zhou, Varuni Abhayarayne, Joseph Akor, Honglan Shi, Paul Ki-Souk Nam, Joel Gerard Burken, John Yang Apr 2025

Maldi-Mass Spectrometry Imaging To Investigate Distribution Of Per- And Polyfluoroalkyl Substances In Exposed Poplar Tissues, Tonglin Zhou, Varuni Abhayarayne, Joseph Akor, Honglan Shi, Paul Ki-Souk Nam, Joel Gerard Burken, John Yang

Miners Solving for Tomorrow Research Conference

No abstract provided.


Arbuscular Mycorrhizal Fungi Combined With Biosolids And Biochar Sustained Phytostabilization And Enhanced Soil Properties Of Mine Tailings, Emma Kettler, Mariam K. Al-Lami, Joel Gerard Burken Apr 2025

Arbuscular Mycorrhizal Fungi Combined With Biosolids And Biochar Sustained Phytostabilization And Enhanced Soil Properties Of Mine Tailings, Emma Kettler, Mariam K. Al-Lami, Joel Gerard Burken

Miners Solving for Tomorrow Research Conference

No abstract provided.


Carrier Analysis Of Alc Lipid Nanoparticles With Lung Cancer Drug, Noah Sparks, Lei Xu, Hu Yang Apr 2025

Carrier Analysis Of Alc Lipid Nanoparticles With Lung Cancer Drug, Noah Sparks, Lei Xu, Hu Yang

Miners Solving for Tomorrow Research Conference

No abstract provided.


Integrating Standards For Infrastructure Improvement And Resilience In University Curricula, Lisa Greenwood, Jennifer Schneider, Sumita Mishra, Yewande S. Abraham, Shriram Karpoora Sundara Pandian Apr 2025

Integrating Standards For Infrastructure Improvement And Resilience In University Curricula, Lisa Greenwood, Jennifer Schneider, Sumita Mishra, Yewande S. Abraham, Shriram Karpoora Sundara Pandian

Articles

In today’s ever-changing world, we are increasingly vulnerable to shocks and stresses that disrupt industry and society. Persistent threats from natural and manmade hazards require our communities and infrastructure to be resilient despite possible disruption. Creating robust infrastructures is founded on operational and physical standards to withstand and respond to threats such as environmental exposures, climate change, and informational security breaches. The significant U.S. investment in infrastructure projects through the Infrastructure Investment and Jobs Act has amplified the need for professionals in engineering and related fields who – in addition to technical knowledge - possess the necessary knowledge and skill …


Dataset: Compositional Analysis And Hydrothermal Liquefaction Of A High-Ash Microalgae Biofilm, Jacob Watkins, Hamza Abdellaoui, Elise Barton, Clayton Lords, Ronald C. Sims Apr 2025

Dataset: Compositional Analysis And Hydrothermal Liquefaction Of A High-Ash Microalgae Biofilm, Jacob Watkins, Hamza Abdellaoui, Elise Barton, Clayton Lords, Ronald C. Sims

Biological Engineering Student Research

This dataset contains biochemical composition data and hydrothermal liquefaction (HTL) yield results for a high-ash microalgae biofilm which was cultivated in effluent from a mesophilic anaerobic digester using polyethylene rotating algae biofilm reactors (RABRs). These data were originally collected for use in a techno-economic analysis of biocrude, biodiesel, and bioplastic production from algae that was cultivated using RABRs for municipal wastewater reclamation.

Biochemical data for the microalgae biomass includes bulk protein, measured both using the Bradford protein assay and by multiplying total N; carbohydrate content, measured using a 3-methyl-2-benzothiazolinone hydrazone / dithiothreitol (MBTH/DTT) assay; total lipid content, measured using a …


Impulse, Spring 2025, Jill Fier, Micayla Standish, Jerome J. Lohr College Of Engineering Apr 2025

Impulse, Spring 2025, Jill Fier, Micayla Standish, Jerome J. Lohr College Of Engineering

Impulse (Jerome J. Lohr College of Engineering Publication)

2 | Faculty, Staff Honored
4 | The State of Lithium
6 | 100 Years of Ag and Biosystems Engineering
8 | Major Milestones
12 | Distinguished Engineer Geldert-Murphy
14 | Distinguished Engineering Heitkamp
16 | By the Numbers
18 | Space Grant Consortium at SDSU
20 | Healthcare Systems Engineering Program
22 | Ridgway Three-Peat
23 | Aerospace Club Launches
24 | Power and Energy Scholarships
25 | More Take Part in Nasa Challenges
26 | Weber Recognized as Student Leader
30 | Wild Hare Racing Ready
32| Sebern’s Success as Sole Operator
34 | Meink: From Prairie to …


Changes In The Western Flank Of The North Atlantic Subtropical High Since 1140 Ce: Extremes, Drivers, And Hydroclimatic Patterns, Joshua C. Bregy, Justin T. Maxwell, Scott M. Robeson, Grant L. Harley, Valerie Trouet Apr 2025

Changes In The Western Flank Of The North Atlantic Subtropical High Since 1140 Ce: Extremes, Drivers, And Hydroclimatic Patterns, Joshua C. Bregy, Justin T. Maxwell, Scott M. Robeson, Grant L. Harley, Valerie Trouet

Publications

Summer circulation and moisture patterns in the Southeast United States are controlled by the position of the North Atlantic subtropical high. In a warming climate, the subtropical high is projected to strengthen and expand west, but there remains uncertainty regarding its variability and linkages to natural drivers. Here, we use a tree-ring network across the Southeast United States to reconstruct the relative intensity of the pressure gradient across the subtropical high’s western flank over the past 870 years. Variations in the flank’s position and the pressure gradient have been a major driver of the hydroclimate—including creating a Southeast-Caribbean moisture dipole—since …


2025 (Spring) Ensi Informer Magazine, Morehead State University. Engineering Sciences Department Apr 2025

2025 (Spring) Ensi Informer Magazine, Morehead State University. Engineering Sciences Department

ENSI Informer Magazine Archive

The ENSI Informer Magazine published in the spring of 2025.


Zooplankton Protect Viruses From Sunlight Disinfection, J. A. Wang, O. Aryal, L. N. Brownstein, H. Shwwa, A. L. Rickard, A. E. Stephens, M. Lanzarini-Lopes, Niveen S. Ismail Apr 2025

Zooplankton Protect Viruses From Sunlight Disinfection, J. A. Wang, O. Aryal, L. N. Brownstein, H. Shwwa, A. L. Rickard, A. E. Stephens, M. Lanzarini-Lopes, Niveen S. Ismail

Engineering: Faculty Publications

Sunlight disinfection is an important inactivation process for enteric viruses in water. Understanding how dark biotic processes, such as zooplankton filter feeding, impact sunlight disinfection for viruses has important implications for public health. This research quantifies the uptake of MS2, a model for enteric viruses, by the filter feeder Branchionus plicatilis (rotifer) and the effects of such uptake on subsequent sunlight inactivation of MS2. Experiments co-incubating MS2 with rotifers showed 2.6 log viral removal over 120 hours. Viable virus was recovered from rotifer bodies after co-incubation, indicating incomplete viral inactivation via ingestion. When live rotifers were co-incubated with MS2 and …


Hybrid Treatment Method Of Biofiltration Preceded With Advanced Oxidation Process For The Removal Of Emerging Contaminants From The Wastewater Treatment Plant Effluent, Anjali Mohan Payathuparambil Apr 2025

Hybrid Treatment Method Of Biofiltration Preceded With Advanced Oxidation Process For The Removal Of Emerging Contaminants From The Wastewater Treatment Plant Effluent, Anjali Mohan Payathuparambil

Theses

The global demand for potable quality water has been on a continuous rise. Consequently, water reuse is now considered as an alternative to significantly expand supplies of freshwater in communities facing water shortages. Most of the conventional wastewater treatment plants (WWTP) are not efficient in the removal of emerging contaminants from the water, which will cause serious issues to the environment, human and animal life. This research investigated the possibilities of treating wastewater for reuse. First, the feasibility of utilizing a biofiltration system without pre-treatment for removing emerging contaminants from the WWTP effluent was investigated. Two types of biofilter media- …


Valorization Of Industrial Wastes To Low-Carbon Minerals, Nandan Nag Apr 2025

Valorization Of Industrial Wastes To Low-Carbon Minerals, Nandan Nag

Civil & Environmental Engineering Theses & Dissertations

This study concentrates on developing methods for utilizing industrial waste materials such as red mud and phosphate slag. In this study, an electrochemical process was developed for recovering iron metal powder from red mud. Red mud is a waste material from aluminum refineries. Although red mud can be utilized as a construction and building material, its use is becoming controversial due to its high metal content, which contributes to its toxicity. However, the high iron oxide content in red mud makes it a good feedstock for producing iron. In this project, we employed an electrochemical technique for extracting iron powder …


Network Analysis Of Sociotechnical Systems, Siva Kadiresan Apr 2025

Network Analysis Of Sociotechnical Systems, Siva Kadiresan

Engineering Management & Systems Engineering Theses & Dissertations

Sociotechnical networks have become integral frameworks in the accomplishment of organizational objectives by increasingly diverse, cross-functional, and technology-enabled modern teams. In cross-disciplinary teamwork, multiple mediating and moderating factors appear to lend context to the effects of team diversity faultlines on team outcomes. In the several decades of research into teamwork from a network perspective, there has been a paucity of empirical studies that examine how team transition processes and cross-disciplinary connections influence the impact of faultlines on team performance. This study investigates the association among perceived teamwork effectiveness, transition processes, cross-functional team connections, and faultlines in the context of sociotechnical …


Endothelial Dysfunction Promotes Age-Related Reorganization Of Collagen Fibers And Alters Aortic Biomechanics In Mice, Liya Du, Jeffrey Rodgers, Nazli Gharraee, Olivia Gary, Tarek Shazly, John F. Eberth, Susan M. Lessner Apr 2025

Endothelial Dysfunction Promotes Age-Related Reorganization Of Collagen Fibers And Alters Aortic Biomechanics In Mice, Liya Du, Jeffrey Rodgers, Nazli Gharraee, Olivia Gary, Tarek Shazly, John F. Eberth, Susan M. Lessner

Faculty Publications

Endothelial dysfunction, defined as a reduction in the bioavailability of nitric oxide (NO), is a risk factor for the occurrence and progression of various vascular diseases. This study investigates the effect of endothelial dysfunction on age-related changes in aortic extracellular matrix (ECM) microstructure and the relationship between microstructural adaptation and the mechanical response. Here, we used groups of NOS3 knockout (KO), NOS3 heterozygotes (Het), and wild-type (WT) B6 mice (controls) to study changes in hemodynamic parameters, collagen fiber organization, and both active and passive aortic mechanics using biaxial pressure myography over a time course from 1.5 to 12 mo. Our …


Endothelial Dysfunction Promotes Age-Related Reorganization Of Collagen Fibers And Alters Aortic Biomechanics In Mice, Liya Du, Jeffrey Rodgers, Nazli Gharraee, Olivia Gary, Tarek Shazly, John F. Eberth, Susan M. Lessner Apr 2025

Endothelial Dysfunction Promotes Age-Related Reorganization Of Collagen Fibers And Alters Aortic Biomechanics In Mice, Liya Du, Jeffrey Rodgers, Nazli Gharraee, Olivia Gary, Tarek Shazly, John F. Eberth, Susan M. Lessner

Faculty Publications

Endothelial dysfunction, defined as a reduction in the bioavailability of nitric oxide (NO), is a risk factor for the occurrence and progression of various vascular diseases. This study investigates the effect of endothelial dysfunction on age-related changes in aortic extracellular matrix (ECM) microstructure and the relationship between microstructural adaptation and the mechanical response. Here, we used groups of NOS3 knockout (KO), NOS3 heterozygotes (Het), and wild-type (WT) B6 mice (controls) to study changes in hemodynamic parameters, collagen fiber organization, and both active and passive aortic mechanics using biaxial pressure myography over a time course from 1.5 to 12 mo. Our …