Digital Commons Network^™

Ai For Life Sciences: From Geometric Protein Modeling To Multimodal Drug Design, Feng Jiang

Computer Science and Engineering Dissertations

Predicting biomolecular interactions, from immune recognition to drug–target binding, is a central problem in the life sciences and computational drug discovery. Deep learning has advanced this area, yet three challenges persist: the topology of large, highly imbalanced interaction networks; structural noise in computationally predicted protein models; and the integration of multimodal information such as functional text and taxonomic annotations. This dissertation develops a coherent set of models spanning immune complex prediction and small-molecule drug design: graph learning that addresses network topology and severe class imbalance; a noise-tolerant method that fuses predicted structures with evolutionary sequence features; and multimodal representation learning …

Navigating The Intersection Of Faa Grant Assurances And Environmental Regulations: Assessing Impacts On Airport Sustainability Efforts, Chad D. Richards

Senior Honors Theses and Projects

Airports in the United States operate within a very complicated regulatory environment that is shaped by federal aviation policy, environmental and state laws, and promises made to the federal government through sponsor assurances, also known as grant assurances. As environmental concerns surrounding aviation continuously grow, airports have been increasingly implementing sustainability initiatives aimed at reducing emissions and improving energy efficiency. Implementing these initiatives is often influenced by regulatory frameworks governing airport operations and infrastructure development. The goal is to examine how federal regulatory structures influence sustainability initiatives at U.S. airports by using a qualitative case study approach to examine sustainability …

Localized Air Pollution Impacts From Data Centers In Northern Virginia, Damian Pitt, Ivan Suen, Ellie Plisko

Institute for Sustainable Energy and Environment Publications and Presentations

This report examins the extent of air pollution emissions resulting from the use of backup generators at data centers in Northern Virginia, including both actual current emissions and potential future emissions, and how those emissions totals compare to other sources of air pollution in the Northern Virginia region. It also examines how exposure to data center emissions correlates with demographic characteristics such as race, income, and education.

We while the air pollution emissions from individual data centers is minor, the collective impact from the 100+ such facilities in the Northern Virginia region is significant. Notably, the cumulative emissions exposure in …

Ransomware As Organization: A Comparative Analysis Of Corporate And Criminal Structures In Conti, George Urling

Theses, Dissertations and Capstones

Cybercriminal groups continue to pose major threats to global cybersecurity. One of the most common types of cybercriminal groups are, “Ransomware-as-a-Service (RaaS)" groups, who create and sell ransomware. While research is conducted into the development of ransomware, there is limited reporting on the organizational structure and habits of RaaS groups. In 2022, prominent RaaS group Conti had their chat logs leaked, with the logs ranging from 2020 to 2022. This study seeks to provide a deeper understanding of RaaS group structures by utilizing the Conti leaked logs as a case study. The study, entitled “Ransomware as Organization: A Comparative Analysis …

A Macrocognitive Design Taxonomy For Simulation-Based Training Systems: Bridging Cognitive Theory And Human-Computer Interaction, Jessica M. Johnson

Virginia Digital Maritime Center (VDMC) Faculty Publications

Simulation-based training systems are increasingly deployed to prepare learners for complex, safety-critical, and dynamic work environments. While advances in computing have enabled immersive and data-rich simulations, many systems remain optimized for procedural accuracy and surface-level task performance rather than the macrocognitive processes that underpin adaptive expertise. Macrocognition encompasses higher-order cognitive processes that are essential for performance transfer beyond controlled training conditions. When these processes are insufficiently supported, training systems risk fostering brittle strategies and negative training effects. This paper introduces a macrocognitive design taxonomy for simulation-based training systems derived from a large-scale meta-analysis examining the transfer of macrocognitive skills from …

Goal-Driven Shared Control In Eeg-Based Brain Machine Interface For Freewill Reaching And Grasping With Movement Intention Detection And Goal Position Decoding, Bhoj Raj Thapa

Theses and Dissertations--Electrical and Computer Engineering

Upper limb motor impairments can severely limit a person’s ability to perform everyday reaching and grasping tasks. Electroencephalogram (EEG)-based brain machine interfaces (BMIs) offer a non-invasive approach for translating neural activity into control signals for assistive devices such as robotic arms. However, traditional EEG-based BMI studies have generally focused on externally cued paradigms, where both movement timing and target selection are specified by the experimenter rather than freely chosen by the user. In addition, shared control offers a practical framework for assistive BMI operation by dividing responsibility between the user and the intelligent robotic system. However, in many EEG-based shared …

Ai-Driven Network Orchestration: Adaptive Routing For Federated Learning Over Software-Defined Hybrid Wans, Osama Abu Hamdan

Computer Science and Engineering Dissertations - Archive

Modern wide-area networks increasingly adopt hybrid architectures that combine high-capacity wired backbones with flexible wireless links to extend connectivity to remote and underserved locations. However, the bandwidth variability inherent in wireless segments creates routing challenges that traditional protocols, designed for static link capacities, cannot adequately address. Simultaneously, Federated Learning (FL) has emerged as a privacy-preserving distributed machine learning paradigm in which geographically dispersed clients collaboratively train shared models without exchanging raw data. When deployed over wide-area networks, FL training is severely bottlenecked by communication overhead, particularly in cross-silo settings where model payloads reach hundreds of megabytes and synchronous aggregation protocols …

Moisture Performance Of Coated Cross-Laminated Timber Under Coastal Conditions In Vertical And Horizontal Orientations With And Without Weather And Vapor Resistive Barriers, Mia Raley

Engineering Theses

Rhode Island is experiencing sea level rise, and more flooding and erosion during storm events due to climate change. The Rhode Island construction industry wants to adopt mass timber, but have concerns with the changing coastal environment on cross-laminated timber (CLT) wall and slab panels. This research aims to understand how coastal conditions affect CLT under different protection conditions, panel orientations, and structure type, by collecting moisture and temperature data on two structures, one commercially-fabricated and one laboratory-fabricated, located on Shell Path from early-July to early-April. Results found that all layers of horizontally-oriented panels benefitted from an additional protective weather-resistant-barrier …

A Comprehensive Statistical And Regional Analysis Of Lng-Powered Marine Vessels On Ghg Mitigation Strategies Considering Existing Bunkering Stations And Gwp Values, Canberk Hazar, Onur Yuksel, Murat Bayraktar

Journal of Marine Science and Technology–Taiwan

This study aims to quantify and analyse emissions from marine vessels that can operate on liquefied natural gas (LNG) but continue to use conventional fuels, largely due to the limited availability of LNG bunkering stations (BSs) over long distances. Four regions have been identified as having high concentrations of LNG-fueled vessels but limited access to operational BSs: the West Coast of the United States of America (USA), South Africa–Good Hope–Madagascar, Northwest Africa, and Brazil. This selection is based on the geographical distribution of these ships and the existing infrastructure. Hourly greenhouse gas (GHG) emissions have been calculated by considering the …

Bio-Based Oxalic Acid Production In Issatchenkia Orientalis Enables Sustainable Rare Earth Recovery, Jingxia Lu, Wenjun Guo, Ziye Dong, Sarang S. Bhagwat, Shih-I Tan, Zhixin Zhu, Andrew Johnson, Jeremy S. Guest, Rick Q. Honaker, Dan M. Park, Yongqin Jiao, Huimin Zhao

Mining Engineering Faculty Publications

The growing demand for rare earth elements (REEs) in clean energy and high-tech industries underscores the need for sustainable recovery methods and a reliable supply of processing chemicals. Here, we establish a microbial platform using the acid-tolerant yeast Issatchenkia orientalis SD108 to produce bio-oxalic acid for REE recovery. By introducing an oxaloacetate cleavage pathway and applying metabolic engineering, the engineered strain produces 39.53 g·L^-1 oxalic acid at pH 4.0 in fed-batch fermentation. The crude fermentation broth, used without purification, efficiently precipitates over 99% neodymium (Nd), 99% dysprosium (Dy), and 98% lanthanum (La) from individual REE chloride solutions. Recovery from …

Characterization Of Full Bridge Strain Transducers For Haulage Equipment Payload Distribution Monitoring, Jean-Pierre Strydom, Steven Schafrik, Zacharias Agioutantis, Matthew J. Beck, Joseph Sottile

Mining Engineering Faculty Publications

Creating a dependable approach for identifying both the mass of a shuttle car and how material is distributed in it removes the need for equipment operators to manually engage the flight chain. The quantification of environmental and installation conditions and the extent of influence considering their combined contribution towards inaccurate or exclusive measurements are to that degree limited. This experimental study investigated how two different strain transducers—installed in a force-shunt configuration—respond to thermo-mechanical loads when used to determine load distribution and position. Initial observations indicated that thermal effects at the installation site contributed to measurement inaccuracies or exclusive readings. The …

Nahb Production Home Competition As A Learning Tool Towards Incorporating Business Skills In Construction Management Programs, George Berghorn, Chandler Jones, M.G. Matt Syal

The Professional Constructor

There is a growing realization in the construction industry that the traditional focus of Construction Management (CM) education on technical competencies (such as scheduling, estimating, and construction methods) is insufficient in preparing graduates to meet the strategic and leadership demands of the modern construction profession. A successful construction company requires more than project execution; it demands expertise in business development, financial management, marketing, risk management, and organizational leadership. The disparity between the technical and business aspects of CM education has produced graduates who may succeed in project management yet find it challenging to engage with comprehensive business operations.

This study …

Scaling Llm Inference: From Novel Attention Mechanisms To Efficient Kv Cache Management, Weishu Deng

Computer Science and Engineering Dissertations

The rapid scaling of artificial intelligence workloads has shifted the dominant performance bottleneck of modern computing systems from compute to memory. Graph neural networks (GNNs) issue increasingly irregular memory accesses, while large language models (LLMs) issue increasingly large ones; in both cases, the relative scaling of memory bandwidth and capacity continues to lag behind the scaling of compute. Consequently, naively executing these workloads on commodity GPUs results in stalled streaming multiprocessors, exhausted high-bandwidth memory (HBM), and serving stacks that incur PCIe transfers on the critical path. This dissertation argues that the efficient scaling of attention-based AI workloads requires the joint …

Developing And Proposing A Passion Project Course With Institutional Backing, Ron Reaser

2026 Scholarly Teaching Conference: Poster Session Papers

Developing and proposing a new course based on your passion project is achievable and rewarding for faculty of any rank, including teaching-track faculty and adjuncts, but it may feel confusing or daunting to glean the course design principles and institutional knowledge necessary to succeed. This presentation recommends a successful and replicable approach based on proactive communication with stakeholders in your unit and across the broader university system. The approach is tailored to faculty members of West Virginia University, Potomac State College, and WVU Institute of Technology.

Seasonal Variations In Co2 Emission From Poultry Manure-Amended Soils In Two Contrasting Tropical Agroecosystems, Gladys M. Akande, Adebayo J. Adeyemo, Chidozie J. Oraegbunam, Iduh J.J. Otene, Ezekiel C. Are, Babatunde S. Ewulo, Chioma M. Ahukaemere, Samuel O. Kolawole, Sunday E. Obalum

Applied Environmental Research

The soil remains the largest carbon sink, the capacity of which varies spatiotemporally and with anthropogenic activities, with implications for carbon dioxide (CO2) emissions and associated global warming. Despite the increasing popularity of organic amendments in the ecologically and anthropoculturally diverse farming systems of tropical Africa, manure-induced CO2 emissions in this region with high soil-carbon-sequestration potential are poorly documented. This study assessed seasonal CO2 emissions from poultry manure-amended sandy-clay-loam and sandy-loam soils in the Rainforest-Savannah and Southern Guinea Savannah zones, respectively, of Nigeria. Following manure application at 3 rates (0, 10, and 15 t ha-1), soil samples were collected during …

Bioremediation Potential Of Indigenous Stutzerimonas Stutzeri 08tbb Isolated From Mercury-Contaminated Gold Mining Sites In Indonesia, Uun Rohmawati, Juanita Hibatullah, Achmad Rodiansyah, Yunita Messe, Dwi Nur Aini Fajriah

Applied Environmental Research

Artisanal and small-scale gold mining (ASGM) widely uses mercury (Hg) in the amalgamation process, and the resulting waste is often discharged directly into the environment, posing serious risks to ecosystems and human health because of the high toxicity of Hg. This study aimed to isolate and screen indigenous Hg-tolerant bacteria from contaminated gold mining sites in Indonesia; characterize the most effective isolate using morphological, biochemical, and molecular approaches; evaluate Hg(II) degradation performance using ICP‒OES, FTIR, and SEM analyses; and identify key metabolites involved in Hg detoxification through untargeted LC–HRMS metabolomics. A total of 51 bacterial isolates were obtained from Hg-contaminated …

Assessment Of Chromosomal Abnormalities In Hybrid Catfish In Reservoir Contaminated With Heavy Metals From Municipal Landfill, Tanadol Savigun, Natchanon Thiratanaboon, Nuttawadee Maneesan, Manop Sriuttha, Lamyai Neeratanaphan

Applied Environmental Research

In this study, the concentrations of heavy metals (As, Cd, Cr and Pb) in water, sediment, and hybrid catfish (Clarias gariepinus x C. macrocephalus) as well as chromosomal abnormalities (CAs) from a reservoir affected by leachate from a municipal landfill were compared to those in an unaffected reservoir. Heavy metal concentrations were analyzed using inductively coupled plasma‒optical emission spectrometry (ICP‒OES). Chromosomes were prepared from kidney cells by direct methods. The As, Cd and Pb concentrations in the water and sediment from both reservoirs were within the Thailand water and soil standards. The concentrations of As and Cd in the water …

Assessing Forest Fragmentation And Edge Expansion In Nan Province, Thailand, Using Landsat Data (2014–2022), Kasidit Rison, Marut Fuangarworn, Chatchawan Chaisuekul

Applied Environmental Research

The increasing pressure from land-use change and agricultural expansion in Nan Province, northern Thailand, has accelerated forest fragmentation and reduced the ecosystem service value (ESV) of the landscape. This study aims to: assess land use and forest fragmentation change in Nan Province between 2014 and 2022, and evaluate the impact of land use change on ESV. Landsat 8 OLI satellite imagery from 2014 and 2022 was used to classify land cover into five types: forest, agriculture, settlements, exposed soil, and others. Forest fragmentation was evaluated using landscape metrics such as patch number, mean patch size, edge length, and core area. …

Application Of Diatom Indices To Monitor Environmental Shifts In The Downstream Tuntang River, Central Java, Mirza Hanif Al Falah, Tri Retnaningsih Soeprobowati, Hadiyanto -, Muhammad Isnaini Ibnu Sabil, Marta Wojewódka-Przybył, Łukasz Kruszewski, Paweł Rydelek

Applied Environmental Research

Diatoms are widely recognized as sensitive bioindicators for reconstructing past water quality and ecological changes in aquatic ecosystems. In this study, multiple diatom-based indices were applied to sediment cores collected from three downstream stations of the Tuntang River, Central Java, to infer long-term environmental change in a tropical river system. A total of 38 sediment subsamples were analyzed, with dominant taxa including Fragilaria crotonensis (2.4–18.6%), Nitzschia palea (3.1–22.4%), and Aulacoseira granulata (2.0–15.8%), indicating sustained nutrient enrichment. Diatom indices consistently classified conditions as mesotrophic to eutrophic throughout the sediment profiles. The occurrence of the marine diatom Cylindrotheca closterium (up to 6.3%) …

Environmental Sustainability Performance And Efficiency In Thailand’S Rajabhat Universities : A Cross-Regional Analysis Of The Impact Rankings, Konstantinos Balis

Applied Environmental Research

Higher education institutions (HEIs) are expected to increasingly communicate their contributions to the United Nations’ Sustainable Development Goals (SDGs), with the rise of alternative sustainability rankings serving as prominent reporting instruments for institutional transparency. In Thailand, Rajabhat Universities, a network of government HEIs historically associated with their mission of teacher training and local development, have been actively participating in the Times Higher Education (THE) Impact Rankings, presenting a unique case study to explore cross-regional sustainability efforts in relation to global benchmarks. To evaluate trends, regional disparities, and engagement performance across the sustainability pillars, this study uses a descriptive quantitative design …

Initial Screening Of Halophilic Plastic-Degrading Bacteria From Mangrove Water And Sediment In Pekalongan, Indonesia, Novia Safinatunnajah, Muhammad Zainuri, Aris Ismanto, Tony Hadibarata, Kunarso -, Sugeng Widada, Hermin Pancasakti Kusumaningrum, Candra Wahyuningsih

Applied Environmental Research

Microplastic pollution in tropical mangrove ecosystems represents an increasing environmental concern, particularly in coastal regions such as Pekalongan, Indonesia, where industrial and residential activities contribute substantially to plastic waste. This study aimed to isolate and preliminarily screen halophilic bacteria from mangrove sediments and seawater collected from a plastic-impacted coastal area. Using mineral salt medium (MSM) supplemented with polyethylene glycol (PEG), six bacterial strains were obtained and evaluated for their potential to interact with polyethylene (PE) and polypropylene (PP) on the basis of gravimetric weight loss measurements. Among the isolates, Halomonas Cupida A1, Marinobacter nauticus A6.3, and Marinobacter nauticus SD5.2 exhibited …

Wideband Acoustic Immittance: Suitable Quantities For Assessing Middle-Ear Status, Kren Monrad Nørgaard, Jingxin Jessica Feng, Susan E. Voss

Engineering: Faculty Publications

This paper investigates the physical significance of ear-canal wave quantities—such as absorbance—that are commonly measured in wideband-acoustic-immittance tests and evaluates whether these quantities uniquely characterize middle-ear function. This is explored using simulations of lumped-element and transmission-line ear canals, along with measurements in three-dimensional-printed uniform and anatomical ear canals of varying geometry, terminated by the same middle-ear simulator. The results demonstrate the following points: (1) Wave quantities computed using estimated or geometrical cross-sectional areas do not uniquely characterize the middle ear because they describe the wave interaction between ear canal and middle ear and are therefore confounded by variations in ear-canal …

Security-Oriented Voice Authentication Using Machine Learning, Ifeoluwa Stella Elegbe

College of Graduate Studies: Theses & Dissertations

This study develops and evaluates a machine learning and deep learning-based voice authentication system for secure identity verification. As traditional authentication methods such as passwords, PINs, and security tokens continue to face challenges, including identity theft, forgetting, and unauthorized access, voice biometrics offers a more secure, convenient, and user-friendly alternative, especially for remote, hands-free, and accessibility-focused applications. The study adopts a closed-set speaker identification framework, where the system determines the most likely speaker from a predefined group of enrolled users. A structured methodology is implemented, beginning with audio preprocessing and feature extraction. Key acoustic features, including Mel-Frequency Cepstral Coefficients (MFCCs), …

Data-Driven Prediction Of Compressive Strength In Pofa-Modified Concrete: A Comparative Study Of Lr, Nlr, And Ann Models, Shuaaib A. Mohammed, Hawdin Ismael Ibrahim, Diar Fatah Abdulrahman Askar, Hersh F Mahmood, Mehdi Khodaei, Soran Abdrahman Ahmad

Mansoura Engineering Journal

Production of concrete results in high CO₂ emissions, high energy demand, and consumption of various raw materials; however, it is one of the most widely used materials in construction to date. Therefore, researchers aim to minimize the impact of concrete production through various methods, such as introducing sustainable sources of materials that can be used in concrete. For instance, agricultural waste materials can be used as partial cement replacement. This study presents a comprehensive data-driven analysis of the effects of POFA on the properties of normal-strength concrete. By synthesizing a database of 196 experimental datasets from existing literature, three …

Optimisation Of Stepped Basin Solar Still With Response Surface Methodology And Machine Learning Methods, M. Balamurugan, V. Santhanam, B. Deepanraj, S. P Manikandan, M. Yuvaperiyasamy, N. Senthilkumar

Mansoura Engineering Journal

This research focuses on enhancing the distillate output of a stepped basin solar still by optimizing key operational variables using Response Surface Methodology (RSM) and advanced machine learning techniques. As water scarcity remains a critical global challenge, solar stills offer a viable, sustainable solution for desalination. These systems offer an energy-efficient approach to converting saline water intofreshwater, providing an alternative to conventional desalination methods. The primary objective was to investigate how variations in solar radiation, step height, and water inlet temperature influence the productivity of the stepped basin solar still. The solar radiation ranged from 600 to 1000 W/m², the …

Anaerobic Digestion Of Variable, Heterogeneous Organic Wastes Under Changing Operational Conditions And Bioaugmentation: Impacts On Process Performance And Microbiome Dynamics, Victoria Holliday

Theses and Dissertations--Biosystems and Agricultural Engineering

Expanding the adoption of anaerobic digestion (AD) is limited by system instabilities caused by feedstock composition and variability. Understanding how changes in feedstock and operational parameters influence microbiome dynamics is essential for developing biology-driven strategies to improve digester stability.

Two semi-continuous reactors, an experimental and a control, operated over 39 weeks across five phases with varying feedstocks and organic loading rates. Substrate-specific enrichment cultures were developed for bioaugmentation and implemented in select phases to assess its impact. Both reactors exhibited similar performance, transitioning through periods of stability, stress, and recovery in response to operational changes. Corresponding shifts in dominant taxa …

Proposed Design Approach Of Bolted Cruciform Stiffened End-Plate Connections And Bolted Circular Flange Plate Connections Under Combined Loading For Enhanced Economy And Performance, Cesar E. Aguirre

Civil Engineering Dissertations

This research will deliver a substantive contribution to the advancement of design practice for bolted circular flange connections and cruciform stiffened end-plate connections — critically evaluating existing approaches, identifying their limitations, and proposing evidence-based design frameworks that enhance structural performance, predictability, and safety across relevant engineering applications.In addition provide economical benefits.

The Lie Group Basis Of Neuronal Membrane Architecture: Why The Hodgkin–Huxley Equations Take Their Form, Robert Melendy, Daniel Blue

Faculty Publications - Department of Electrical Engineering and Computer Science

The Hodgkin–Huxley equations have successfully described neuronal excitability for over seventy years, yet their mathematical structure remains empirically justified rather than theoretically explained. Why are gating variables bounded between 0 and 1? Why does sodium conductance depend on m³h rather than other combinations? Why does potassium depend on n⁴? Why do all rate functions contain exponential voltage dependencies? Why are the kinetics first-order? We demonstrate that these structural features arise naturally from three fundamental physical symmetries governing ion channel dynamics: the compactness of conformational state space, the scaling invariance of membrane conductance, and temporal translation invariance. …

Rm Sotheby’S Construction Of Value In The High-End Car Market, Pablo Mijares Musi

MA Theses

The purpose of my thesis is to tell and enlighten any readers how the most prestigious and iconic auction house in the world, RM Sotheby’s sells more than just cars from the high-end car market and how the auction house adds value to through storytelling and provenance from each vehicle.  In today’s luxury market economics, we see somewhat of a radical shift. The high-end car market has moved into a very refined area where these beautiful machines are no longer seen and appraised just for their aesthetic design and mechanical engineering, now we see new value drivers for these works …

Wings Of Perception: Investigating Customer Sentiments In Indian Aviation Sector, Yashodhan Karulkar, Kaiwan Vaghchhipawala, Aditya Trivedi, Anushree Talekar

Journal of International Technology and Information Management

India's aviation sector, a key contributor to the nation's economy, has experienced rapid growth, supporting nearly 7.5 million jobs and contributing approximately $30 billion annually to the GDP (Gross Domestic Product). The growth, driven by increased demand for air travel and government incentives, has resulted in more competition among carriers. In the competitive market, it is necessary to understand customer preferences to enhance the quality of service and maintain a competitive edge. The dissemination of customer opinions on social media and review platforms offers airlines the opportunity to access passenger views. However, extracting useful information from this unstructured data is …