Digital Commons Network^™

Intercellular Mitochondrial Transfer Contributes To Microenvironmental Fate Redirection Of Mammary Cancer Cells, Julie Sofie Bjerring

Biomedical Sciences Theses & Dissertations

The dynamic cellular microenvironment, made up of resident cells and various macromolecules, differs markedly across tissues in the body. The multidirectional signals that cells receive from this microenvironment, along with the signaling they send back, heavily influence their physiology and behavior. Recent important findings have further validated this notion as the mammary microenvironment has been shown to suppress tumor progression by redirecting cancer cells to adopt a normal mammary epithelial progenitor fate in vivo. However, the mechanism(s) driving changes in metabolic reprogramming and cancer fate redirection is understudied. The work presented in this dissertation focuses on exploring the impact of …

Feasibility Study Of Oyster Shell Filtration Media For Stormwater Pollutants Removal, Sadiq Omer

Civil & Environmental Engineering Theses & Dissertations

The depletion of resources has raised interest in reusing or incorporating by-products into alternative materials. In the effort for net zero emissions, waste reduction, and a circular economy, it is crucial to reinvent the alternative utilization strategy for by-products as construction materials sustainably. This research examines the alternative utilization strategy for oyster shell by-products in regular stormwater pollutant removal best management practices (BMPs).

Numerous research has examined the utilization of oyster shell waste as a construction material in Asia and Europe, specifically focusing on the physical properties of crushed oyster shells as alternatives for aggregates. No studies have been identified …

Optical Investigation Of A Low-Pressure Plasma In A Superconducting Radio-Frequency Cavity, Zachary A. Caudell

Electrical & Computer Engineering Theses & Dissertations

The state-of-the-art cryomodules for particle accelerators use superconducting radio-frequency (SRF) cavities. It is known that accumulation of hydrocarbon impurities reduces the cavity surface work function, decreasing cryomodule performance metrics such as field emission, thermal stability, and accelerating gradients. An in-situ method of plasma processing has recently been developed to clean the cavities and restore cryomodule performance [1]. This study is to understand the properties of the low-pressure plasmas generated in a C100 SRF cavity and ultimately to improve the performance of plasma surface cleaning using optical emission spectroscopy. Using a 500 mm focal length Czerny-Turner monochromator coupled with a photomultiplier …

Delivery Of Tgfβ3 From Magnetically Responsive Coaxial Fibers Reduces Spinal Cord Astrocyte Reactivity In Vitro, Jessica L. Funnell, Jasper Fougere, Diana Zahn, Silvio Dutz, Ryan J. Gilbert

Chemical and Biochemical Engineering Faculty Research & Creative Works

A spinal cord injury (SCI) compresses the spinal cord, killing neurons and glia at the injury site and resulting in prolonged inflammation and scarring that prevents regeneration. Astrocytes, the main glia in the spinal cord, become reactive following SCI and contribute to adverse outcomes. The anti-inflammatory cytokine transforming growth factor beta 3 (TGFβ3) has been shown to mitigate astrocyte reactivity; however, the effects of prolonged TGFβ3 exposure on reactive astrocyte phenotype have not yet been explored. This study investigates whether magnetic core-shell electro spun fibers can be used to alter the release rate of TGFβ3 using externally applied magnetic fields, …

Editorial: Novel Computational Fluid Dynamics Methods For Diagnosis, Monitoring, Prediction, And Personalized Treatment For Cardiovascular Disease And Cancer Metastasis, Zahra Keshavarz Motamed, Nima Maftoon, Lakshmi Prasad Dasi, John F. Ladisa Jr.

Biomedical Engineering Faculty Research and Publications

No abstract provided.

Atmospheric Waves Experiment (Awe) Advanced Mesopheric Temperature Mapper (Amtm) Optical System Design, Alignment, And Image Quality Verification, James Champagne, Roy Esplin, Tyrel Rupp, Greg Hopkins, Burt Lamborn, Erik Syrstad, Mike Holt, Matt Ralphs

Space Dynamics Laboratory Publications

The AWE AMTM is a wide field-of-view (WFOV) infrared imaging radiometer designed for use in measuring the P₁(2) and P₁(4) emission lines of the earths OH layer. From these measurements, the atmospheric temperature is determined and finally images of gravity waves will be produced as the AWE field of view transverses the OH layer. Designed, built, and characterized by Utah State University (USU) and its Space Dynamics Laboratory (SDL), the sensor has been externally mounted to the International Space Station (ISS) looking nadir. Images will be collected and analyzed for a minimum of two years. The …

A Novel Approach To Evaluate Seatbelt Non-Compliance Of Drivers In New Jersey, Md Arifuzzaman Nayeem

Theses and Dissertations

This study intends to investigate the non-compliant behavior of drivers with seatbelt use in New Jersey. By examining various factors such as temporal and roadway characteristics, this study seeks to identify the underlying causes of this seatbelt non-compliance behavior. To overcome the limitations of traditional methods like cross-sectional data collection, a novel approach known as moving vehicle method was employed. To gain further insights, hypothesis tests were performed across the entire dataset to pinpoint significant temporal, roadway, and geometric factors contributing to non-compliant behaviors. In the subsequent step, the association of other risky behaviors like speeding and distracted driving with …

Final Report - Mixed Reality For Beyond Visual Line-Of-Sight Bridge Inspection Using Robot-Assisted Nondestructive Evaluation, Genda Chen, Joel Runji

Project IM-5

To improve data consistency, work efficiency, inspector safety, and cost effectiveness during routine inspections, drones have been increasingly used in recent years to support imaging and scanning over the surface of various elements in a bridge for surface condition assessment. Most drones are operated manually within a visual line of sight and unable to inspect river-crossing bridges completely since not all elements can be viewed by a drone operator using a binocular. Even for autonomous drones with collision-avoidance features, physical interaction with a bridge for nondestructive evaluation (NDE) is currently impossible in practice. An alternative solution with robot-assisted remote nondestructive …

Conversion Of Fish Waste Oil Into Biofuel: An Experimental Study, Mahmoud A. Mohamed, Hany A. Elazab, Mamdouh A. Gadalla, Fatma A. Ashour

Chemical and Biochemical Engineering Faculty Research & Creative Works

Egypt is famous for its fish wealth, given its large coasts and freshwater resources, especially of Nile Tilapia and Mugilid fish. It was estimated that domestic fish production increased from 889 thousand tonnes in 2005 to 1620 thousand tonnes in 2016. Thousands of tonnes of fish are consumed yearly, generating substantial amounts of fish waste and residues. Some 26% of the fish consumed is a typical waste. Fish wastes have a significant role in many processes and applications. They are used as feedstock for producing fish meals, a major by-product of fish waste oil. Fish oil is extracted for medical …

Final Report - An Interactive System For Training And Assisting Bridge Inspectors In Inspection Video Data Analytics, Genda Chen, Ruwen Qin, Mohammad Hossein Afsharmovahed, Kevin Lai, Ritesh Sharma

Project WD-4

This project aims to develop an interactive, web-based system to assist bridge inspectors in machine learning and video analytics for a rapid condition state assessment of bridge elements in accordance with the 2019 Manual for Bridge Element Inspection. Referred to BridgeNet, the system includes region-based convolutional neural network (RCNN) models for bridge element and defect segmentation and an inspection video analytic tool that is integrated into a unified graphical user interface (GUI). It provides users with an image-based testbed of modulated RCNN models. The BridgeNet has evolved in four phases: (1) backend and frontend framework setups, (2) Mask-RCNN-based bridge segmentation, …

Final Report - Hyperspectral Imaging And Analysis For Steel Paint Condition Assessment, Hongyan Ma, Genda Chen, Pengfei Ma

Project SN-9

This project aimed to understand the durability of multiple coating settings that had been widely used in highway bridges. Coatings can prevent their substrate from being contacted by aggressive particles and thus corrosion to preserve structural components. However, the wide selection of coatings for steel girders or truss can greatly impact the serviceability of bridges. This project studied four types of top-coat materials (epoxy, Alkyd, acrylic, and polyurethane) and two types of under-coat materials (epoxy and acyclic). The coatings were configured as two-layer and three-layer systems to evaluate their difference in durability. The degradation process of the coatings was monitored …

Electronic Communication Between Co And Ru Sites Decorated On Nitrogen-Doped Carbon Nanotubes Boost The Alkaline Hydrogen Evolution Reaction, Meng-Ting Gao, Ying Wei, Xue-Meng Hu, Wenj-Jie Zhu, Qing-Qing Liu, Jin-Yuan Qiang, Wan-Wan Liu, Ying Wang, Xu Li, Jian-Feng Huang, Yong-Qiang Feng

Journal of Electrochemistry

Designing highly efficient Pt-free electrocatalysts with low overpotential for an alkaline hydrogen evolution reaction (HER) remains a significant challenge. Here, a novel and efficient cobalt (Co), ruthenium (Ru) bimetallic electrocatalyst composed of CoRu nanoalloy decorated on the N-doped carbon nanotubes (CoRu@N-CNTs), was prepared by reacting fullerenol with melamine via hydrothermal treatment and followed by pyrolysis. Benefiting from the electronic communication between Co and Ru sites, the as-obtained CoRu@N-CNTs catalyst exhibited superior electrocatalytic HER activity. To deliver a current density of 10 mA·cm^–2, it required an overpotential of merely 19 mV along with a Tafel slope of 26.19 mV·dec …

The Importance Of Humanities In A Career-Focused Educational Environment, Geoff Zylstra, Jill Belli, Candido Cabo, Sean Macdonald, Robin Michals, Ann Marie Sowder, Christopher B. Swift

Publications and Research

The humanities have the potential to enhance STEM curriculum in career-oriented professional degree programs. As part of a larger college-wide initiative to develop interdisciplinary curricula, the National Endowment for the Humanities (NEH) awarded a grant to New York City College of Technology to explore the relationship between the humanities and career-focused degree programs in STEM departments. This article describes the design and implementation of coursework that bridges the curricular divides between humanities disciplines and technical or career-focused disciplines by bringing the humanities to bear on science and technology-oriented courses. Specifically, the humanities served to improve technical skills for students in …

The Effectiveness Of Certain Biological Additives Considered By-Products Of The Food Industry In Baker’S Yeast Activation, Nataliya E. Kulikova, Antonina G. Chernobrovina, Natalia N. Roeva

CHEMISTRY AND CHEMICAL ENGINEERING

One of the ways to increase the efficiency of the activation process of baking yeast is the use of waste and by-products of the food industry as nutrient media. The goal of the study was to develop ways to activate yeast in a nutrient medium with dietary supplements: potato cell sap, whey and quince pomace powder. We demonstrated the effectiveness of the use of biological additives (potato cell juice, quince pomace powder, whey), which are waste or by-products of the food industry to activate yeast. We have established that incubation in a nutrient medium with dietary supplements has a beneficial …

Multi-Functional Gelatin-Dithiolane Hydrogels For Tissue Engineering, Saad Asim, Cody Tuftee, Asma Talib Qureshi, Rachel Callaghan, Moira L. Geary, Mithun Santra, Vaibhav Pal, Ilayda Namli, Gary Hin Fai Yam, Ibrahim T. Ozbolat, Muhammad Rizwan

Michigan Tech Publications

Biomaterials that integrate multiple functionalities, mimic the extracellular matrix (ECM) microenvironment to support cellular growth, and adhere robustly to damaged tissues are highly needed to advance tissue engineering. Protein-based biomaterials are promising due to their inherent biocompatibility, biomimicry, biodegradation, and cell-supportive properties. Herein, by leveraging the unique ability of dithiolanes to generate on-demand in situ thiols, a new class of dithiolane-modified, protein-based biomaterial that combines unique, seemingly opposing functions for tissue engineering is developed. Dithiolane-modified gelatin, a model protein used herein, enabled photoinitiator-free photo-crosslinking to form multi-functional gelatin-dithiolane (GelDT) hydrogels, which displayed exceptional long-term stability in cell culture media ( …

Fatigue-Resistant Mechanoresponsive Color-Changing Hydrogels For Vision-Based Tactile Robots, Jiabin Liu, Wei Li, Yu She, Sean Blanchard, Shaoting Lin

School of Industrial Engineering Faculty Publications

Mechanoresponsive color-changing materials that can reversibly and resiliently change color in response to mechanical deformation are highly desirable for diverse modern technologies in optics, sensors, and robots; however, such materials are rarely achieved. Here, a fatigue-resistant mechanoresponsive color-changing hydrogel (FMCH) is reported that exhibits reversible, resilient, and predictable color changes under mechanical stress. At its undeformed state, the FMCH remains dark under a circular polariscope; upon uniaxial stretching of up to six times its initial length, it gradually shifts its color from black, to gray, yellow, and purple. Unlike traditional mechanoresponsive color-changing materials, FMCH maintains its performance across various strain …

A Review Of Geopolymer Cement, From Two-Part Geopolymer To One-Part Geopolymer Cement And Its Geotechnical Applications, Khadhra Allali, Nabil Bella, Ilham Aguida Bella, Oussama Khodjet El Fehem, Maria Victoria Borrachero, Jordi Payá, José Monzó

Emirates Journal for Engineering Research

Abstract

Portland cement, a crucial construction material, has been used extensively in various geotechnical projects. However, its over-reliance has led to environmental concerns, particularly regarding carbon dioxide (CO₂) emissions during its production. Sustainable development involves the development of cement alternatives that are less damaging to the environment. Geopolymer cement can be a potential partial replacement for conventional Portland cement that can minimize carbon dioxide emissions and convert various by-products into useful products. Traditional geopolymer cement is composed of two components: an alkaline activator solution and a solid aluminosilicate precursor (other than water), and its production requires the manipulation …

Experimental Examination Of Enhanced Nanoceramic-Based Self-Cleaning Sprays For High-Efficiency Hydrophobic Photovoltaic Panels, Iman El-Mahallawi, Merna Abdrabo, Ahmed Elkaseer Prof., Engy Elshazly, Mohamed S. El-Deab

Renewable Mechanical Energy

Dust deposition poses a significant challenge in the implementation of photovoltaic panels (PV) especially in hot and dusty environments, such as the Middle East and North Africa (MENA) region. This issue leads to progressive degradation of PV efficiency and output power. In this context, this research work aims to improve PV performance by developing self-cleaning sprays as a preventative solution. Different concentrations of SnO2 and TiO2 nanoceramics were dispersed in isopropyl alcohol solvent to reduce the mixture’s viscosity and facilitate smooth spraying on solar panels, whose efficiency was continually assessed in outdoor conditions. Although less commonly used for this application, …

Chacahoula 2024, Vol 91, Alayna Pellegrin

Chacahoula

MERGING REALITIES:

The 2023 issue of Chacahoula includes December 2023 and May 2024 graduating classes, as well as stunning photography of Week of Welcome, Homecoming, Mardi Gras, and Spring Fever. With features covering notable students, faculty, and staff, this year's time capsule beautifully preserves an academic year in the life of the University of Louisiana at Monroe.

R&D And Application Of An Experimental System For Coal Permeability Enhancement Through Resonance Under The Excitation Of Low-Frequency Vibration, Wen Zhihui, Guo Shuqian, Wei Jianping, Zhang Tiegang, Wang Jianwei, Zhang Libo, Ren Yongjie

Coal Geology & Exploration

Objective As an emerging green, efficient method for enhancing coal permeability, coal resonance under the excitation of vibration waves works by stimulating the development of pores and fractures in coals using the stress waves generated by low-frequency vibration. To investigate the impacts of excitation frequency, stress field, and resonance effect on permeability enhancement, as well as exploring the mechanisms behind coal permeability enhancement using the method, this study independently designed and developed an experimental system. Methods The system, consisting of a mainframe control unit, a coal-sample clamping unit, a vibrational excitation unit, and a coal vibration parameter monitoring unit, allows …

A Tin-Gtp Algorithm-Based Technique For 3d Geological Modeling Of Coal Mines, Wang Xiaohui, Liu Zaibin, Zhang Dongliang, Ma Liang, Chen Baohui, Lei Xiaorong, Bai Baojun, Yan Junsheng

Coal Geology & Exploration

Background A 3D geological model of a coal mine serves as an essential prerequisite to guiding the safe and efficient production of coal mines, holding great significance for precise coal mining and geological guarantee. Especially in complex geologic conditions, the failure of geological models to accurately describe the relationship between structures and strata will affect the mining area planning, mining processes, and production efficiency during the production of coal mines. Methods With the Qipanjing Coal Mine in the Zhuozishan Coalfield, Inner Mongolia, as an example, this study investigated the technology for high-accuracy 3D geological modeling of coal mines based on …

Analytical Model For Reactive Solute Transport In A Channel-Matrix System, Wei Nana, Li Xu, Xu Guangquan, Zhang Haitao, Shao Zefan

Coal Geology & Exploration

Objective The accurate quantitative characterization of fractured media and the theoretical research on solute transport in fractured media have become the key to the prevention and control of groundwater contamination in fractured aquifers. Currently, fractured aquifers are generalized to horizontal fractures, ignoring the geometric characteristics of the open parts of fractures, called channels, and the impacts of matrix diffusion on solute transport. Methods A model for solute transport in a single channel-matrix system was established, obtaining the semi-analytical solutions using Laplace and numerical inverse transforms. The COMSOL Multiphysics software was employed to construct a numerical model for verification. Furthermore, the …

Accumulation Patterns And Exploitation And Utilization Targets Of Geothermal Resources In The Coal-Bearing Area In North China, Pang Zhonghe, Duan Zhongfeng

Coal Geology & Exploration

Objective China is a major producer and consumer of coal resources in the world. The urgent need for the transition of the coal industry necessitates the investigation of both the origin and distribution patterns of geothermal resources in the coal-bearing areas of the country. The coal-bearing area in North China, with geothermal reserves accounting for 74.7% of the whole country, stands out as one of the areas with the most abundant geothermal resources nationally. This area encompasses four major coal-bearing basins: the Bohai Bay, Ordos, Qinshui, and Southern North China, with the lithospheric thermal state gradually weakening from east to …

Distracted Driving: Identification, Contributing Factors, And Safety Countermeasures, Ahmed Sajid Hasan

Theses and Dissertations

Distracted driving is a hazardous behavior responsible for 25% of all fatal traffic crashes in New Jersey. While traditional methods such as surveys, videos, and simulations have been used to identify and evaluate distracted driving events, these approaches primarily provide cross-sectional data that fails to capture the true rate of distraction on the road. This study addresses this limitation by collecting longitudinal data on distracted driving events across selected corridors in New Jersey. A data collection team continuously drove through these corridors, manually counting and video recording driver distraction events. The collected data was then analyzed to assess the significance …

Use Of Pulsed Electric Fields And Hydrogen Peroxide For Pre And Postharvest Strategies To Reduce Microbial Loads On Fresh Produce, Zachary Rosenzweig

Theses and Dissertations

Several issues exist within the agricultural industry surrounding failure to prevent pathogen transfer to plants preharvest and failure to decontaminate foods postharvest. Fresh produce, like leafy greens, pose a large threat to public safety if contaminated because they are minimally processed and often eaten raw. Numerous outbreaks have been linked to fresh produce in recent decades, with irrigation water emerging as a potential source. These outbreaks have severe economic repercussions and can contribute to millions of hospitalizations and deaths each year, worldwide. This thesis focuses on the usage of pulsed electric fields (PEF) and hydrogen peroxide (H2O2) as a means …

Structural Changes Likely Cause Chemical Differences Between Empty And Full Aav Capsids, Caryn Heldt, Molly A. Skinner, Ganesh S. Anand

Michigan Tech Publications

Due to the success of adeno associated viruses (AAVs) in treating single-gene diseases, improved manufacturing technology is now needed to meet their demand. The largest challenge is creating a process to separate empty and full capsids. Patients received larger capsid doses than necessary due to the presence of empty capsids. By enabling the better separation of empty and full capsids, patients would receive the greatest therapeutic benefit with the least amount of virus capsids, thus limiting potential side effects from empty capsids. The two most common empty/full separation methods used in downstream processing are ultracentrifugation and anion exchange chromatography. Both …

Nanofiber-Hydrogel Composite Scaffold Fabrication Methods For Peripheral Nerve Regeneration, Jacob Lee Carter

Theses and Dissertations

Nerve graft conduits (NGCs) are a rapidly advancing field for treating peripheral nerve injuries that aim to guide the growth of regenerating axons across damaged gaps. A more effective NGC can be manufactured by combining the use of nanofibers to act as guidewires within a 3-D hydrogel that imitates the extracellular matrix of nerve tissue. Several methods have been developed to embed aligned nanofibers in an ordered architecture within a hydrogel matrix. The first method involves layer-by-layer additive manufacturing to create NGCs with rows of polycaprolactone (PCL) nanofibers surrounded by a gelatin methacrylate (GelMe) hydrogel in a 3-D structure. A …

Neuro-Symbolic Ai For Deep Analysis Of Social Media Big Data, Vedant Khandelwal, Manas Gaur, Ugur Kursuncu, Valerie Shalin, Amit P. Sheth

Faculty Publications

This tutorial introduces a neuro-symbolic AI framework to analyze big data from social media platforms. Integrating human-curated knowledge through symbolic AI with the pattern recognition capabilities of neural networks enhances the adaptability and efficiency of traditional neural network approaches. Knowledge-guided zero-shot learning techniques enable swift adaption to new linguistic contexts and emerging events [6]. Participants will explore how to design, develop, and utilize these models in specific domains, such as public health surveillance, that require dynamic adaptation to new terminologies. This session The tutorial aims to equip attendees with practical skills and a deep understanding of how to apply neuro-symbolic …

Model Predictive Control Of A Grid-Scale Thermal Energy Storage System In Relap5-3d, Jaron Wallace, John Hedengren, Kody Powell, Matthew Memmott

Faculty Publications

This research delves into the integration and control of a Thermal Energy Storage (TES) system with a Small Modular Reactor (SMR), specifically the NuScale VOYGR SMR module in RELAP5-3D. The research methodology centered on modeling the NuScale VOYGR SMR, a light water pressurized water reactor (LWR) with a power output capacity of 77 MWe per module. The reactor and plant details were sourced from NuScale's final safety analysis report and supplemented by information from the NuScale website. The SMR plays a crucial role in energy generation, and to manage and dispatch the produced energy effectively, a robust storage system …

The Role Of Micromobility In The Changing Urban Mobility Landscape, Mostafa Jafarzadehfadaki

All ETDs from UAB

The growing prevalence of micromobility has significantly impacted urban mo-‎bility, offering a sustainable and convenient alternative for short trips in urban settings. ‎As cities grapple with increasing congestion, pollution, and the demand for efficient ‎mobility solutions, micromobility options like e-scooters and e-bikes have emerged as ‎popular modes of transportation, particularly in densely populated areas. While earlier ‎research has contributed to understanding micromobility and its impact on urban set-‎tings, significant knowledge gaps still exist. Therefore, a comprehensive study is neces-‎sary to explore the multifaceted dimensions of e-scooter adoption, usage patterns of mi-‎cromobility, and their implications for urban transportation systems and traffic …