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Imine Crosslinked, Injectable, And Self-Healing Fucoidan Hydrogel With Immunomodulatory Properties, Asma Talib Qureshi, Shajia Afrin, Saad Asim, Muhammad Rizwan Apr 2025

Imine Crosslinked, Injectable, And Self-Healing Fucoidan Hydrogel With Immunomodulatory Properties, Asma Talib Qureshi, Shajia Afrin, Saad Asim, Muhammad Rizwan

Michigan Tech Publications

Biomaterials with inherent anti-inflammatory properties and the ability to foster a pro-regenerative environment hold significant promise for enhancing cell transplantation and tissue regeneration. Fucoidan, a sulfated polysaccharide with well-documented immune-regulatory and antioxidant capabilities, offers strong potential for creating such biomaterials. Yet, there is a lack of engineered fucoidan hydrogels that are injectable and provide tunable physicochemical properties. In this study, the ability of fucoidan to undergo periodate-mediated oxidation is leveraged to introduce aldehydes into backbone (oxidized fucoidan, OFu), enabling the formation of reversible, imine-crosslinks with amine-containing molecules such as gelatin. The imine-crosslinked OFu-gelatin hydrogel provided excellent control over gelation rate …


Hydrologic Decision Support In The Nile Basin: Creating Status And Outlook Products From The Geoglows Hydrologic Model, Rachel Huber Apr 2025

Hydrologic Decision Support In The Nile Basin: Creating Status And Outlook Products From The Geoglows Hydrologic Model, Rachel Huber

Theses and Dissertations

Decision makers and stakeholders need information about current and future streamflow to make informed decisions and we show how the GEOGLOWS Hydrologic Model, known as River Forecast System (RFS), can be used to provide hydrologic status and outlook products to inform these decisions. We examine a specific use case of RFS in the Nile River Basin and how RFS is used to provide users with hydrologic status products. We work with stakeholders at the Nile Basin Initiative to assess their needs for this information. We use basic low flow calculations to compute the Standardized Streamflow Index (SSI) and the 95th …


Systematic Analysis On The Applications Of Infrastructure Asset Management In Utah, Kelvin Kozakevitch Apr 2025

Systematic Analysis On The Applications Of Infrastructure Asset Management In Utah, Kelvin Kozakevitch

Theses and Dissertations

Public infrastructure is essential to a region’s economic stability and quality of life, especially its rural infrastructure where most consumable and essential goods derive from. Given the high capital investment required for infrastructure development and maintenance, asset management plans (IAM) are critical. Even though academic research exists on the problems rural infrastructure management face, little is known about the actual state, barriers and causes for the challenges IAM faces in rural Utah. This study examines the current challenges and barriers in IAM among rural communities in Utah. Employing a grounded theory approach, data was collected through a two-phase methodology: phase …


Enabling Next-Generation Microfluidics Through Advances In High-Resolution 3d Printing, Matthew S. Viglione Apr 2025

Enabling Next-Generation Microfluidics Through Advances In High-Resolution 3d Printing, Matthew S. Viglione

Theses and Dissertations

This dissertation advances the field of microfluidic device fabrication through the development and application of high-resolution 3D printing technologies. The convergence of stereolithography (SLA) with digital light processing (DLP) has created unprecedented opportunities for microfluidic device fabrication, enabling truly three-dimensional structures with feature sizes approaching the single-micron scale. Building upon foundational work in custom 3D printer development, this research addresses critical limitations in 3D printing that have historically constrained microfluidic innovation, spanning multiple generations of custom 3D printers and technical innovations that have enabled the fabrication of increasingly complex microfluidic devices while enhancing resolution, repeatability, speed, and accessibility. A comprehensive …


A Low-Cost Micro Actuator Driven By Electrowetting-On-Dielectric, Behzad Parsi Apr 2025

A Low-Cost Micro Actuator Driven By Electrowetting-On-Dielectric, Behzad Parsi

Theses and Dissertations

Microfluidic techniques have been shown to address limitations of reconfigurable radio frequency (RF) antennas and filters in efficiency, power handling capability, cost, and frequency tuning. However, the current devices suffer from significant integration challenges associated with packaging, actuation, and control. Recent advances in reconfigurable microfluidics that utilize the motion of a selectively metalized plate (SMP) for RF tuning have demonstrated promising RF capabilities but have exposed a need for an accurate fluid actuation model. This research presents models for the dynamics of plate actuation under multiple scenarios. In the first phase, the mechanical motion of a moving plate (e.g. SMP) …


Heavy Ion Testing Of Versal Acap Ai Engines, Caleb S. Price Apr 2025

Heavy Ion Testing Of Versal Acap Ai Engines, Caleb S. Price

Theses and Dissertations

With recent developments in artificial intelligence (AI), there has been an ever increasing need for computation power in space. These AI models are traditionally implemented on GPUs. However, these units come at a high cost in terms of weight and power usage. Due to these limitations, many organizations are turning to the Versal ACAP device, a system on chip (SOC) with hundreds of AI engines. This option delivers more computation per watt than a traditional GPU. The desire to use Versal ACAP in space has created a need to perform radiation testing on the device. Extensive testing has been performed …


Gnss-Denied Navigation Using Lte Signals Of Opportunity On Low-Cost, Low-Swap Hardware, Tyler Sweat Apr 2025

Gnss-Denied Navigation Using Lte Signals Of Opportunity On Low-Cost, Low-Swap Hardware, Tyler Sweat

Theses and Dissertations

Global navigation satellite system (GNSS) navigation is crucial in the operation of unmanned aerial vehicles (UAV). GNSS signals are susceptible to jamming, spoofing, multipath, and urban canyons and may provide incorrect position information or may not be available at all. For autonomous missions, a backup for GNSS is desirable in the event that it is unavailable. Terrestrial cellular signals are a promising option for navigation because they are continuously transmitted at higher power levels. Optimizing hardware size, weight, and power (SWaP) is critical for UAVs to maximize endurance, payload capacity, and operational efficiency. We present a system that uses long-term …


Improving Erosion Resistance And Revegetation Of Wildfire-Altered Soils Using Microbial Induced Calcite Precipitation, Ahsan Ali Apr 2025

Improving Erosion Resistance And Revegetation Of Wildfire-Altered Soils Using Microbial Induced Calcite Precipitation, Ahsan Ali

Doctoral Dissertations and Master's Theses

Climate change is causing wildfires to occur more frequently and with higher intensity. Leading to wide range of impacts on agriculture, infrastructure, and the environment. Wildfires affect soils by burning their organic matter, resulting in an immediate deplete of nutrients and a significant reduction in nitrogen level. Wildfires also alter soils’ physical properties and make them less resistant to erosion which results in debris flows when wildfire are followed by a rainfall event. The reduced activity of microorganisms that aid in nutrient absorption makes the soil less effective in supporting plant life. Microbial Induced Calcite Precipitation (MICP) was found to …


Durability And Steel Corrosion Resistance Of Fly Ash Concrete Exposed To Groundwater, Mohamed Ahmed Bayomy, Khaled M. Osman, Hala Emad Elden Fouad Apr 2025

Durability And Steel Corrosion Resistance Of Fly Ash Concrete Exposed To Groundwater, Mohamed Ahmed Bayomy, Khaled M. Osman, Hala Emad Elden Fouad

Mansoura Engineering Journal

This article proposes replacing Ordinary Portland Cement (OPC) with a fly ash (FA)-based geopolymer (GP) material, activated by a chemical activator, as the binding material. A 90-day study was conducted to evaluate the performance of fly ash geopolymer concrete (GPC) in a corrosive environment (groundwater). Scanning electron microscopy (SEM), compression testing, and energy-dispersive X-ray spectroscopy (EDX) were used to assess the toughness of the samples. Additionally, the linear polarization resistance (LPR) method was employed to measure the corrosion of steel embedded in the concrete structures. The comparison shows that increasing the fly ash (FA) content in geopolymer concrete (GPC) enhances …


Learning Through Leadership, Mike Alison Apr 2025

Learning Through Leadership, Mike Alison

ASEM Capstones

2025 ASEM 620 Capstone Project


The Human Element In Nuclear Safety, Daniel Vincent Gascon Apr 2025

The Human Element In Nuclear Safety, Daniel Vincent Gascon

ASEM Capstones

2025 ASEM 620 Capstone Project


Measuring The Effects Of The Leaves On Stalk Strength And Dynamic Response In Maize, Grant C. Ogilvie Apr 2025

Measuring The Effects Of The Leaves On Stalk Strength And Dynamic Response In Maize, Grant C. Ogilvie

Theses and Dissertations

Maize is one of the most widely cultivated grains in the world, making it crucial to world food security and important economically. One major problem in maize production is stalk lodging (greensnap), which results in billions of dollars in lost harvests annually for maize farmers in the US alone. Understanding the mechanical properties of maize plants is crucial to addressing this problem. Previous studies have suggested that the leaf blades and leaf sheaths affect maize mechanical properties. The objectives of this thesis are twofold: to present measurement techniques for the stalk bending strength, damping ratio, and natural frequency of maize …


A Novel Wrench Decomposition And Development Of A Large-Scale Soft Robot For Displacement-Based Human-Robot Collaborative Manipulation, Dallin Cordon Apr 2025

A Novel Wrench Decomposition And Development Of A Large-Scale Soft Robot For Displacement-Based Human-Robot Collaborative Manipulation, Dallin Cordon

Theses and Dissertations

This work represents an examination of various facets of physical human-robot collaborative manipulation and the implementation of compliant, soft-robotic manipulators. A survey of physical human-human interaction and haptic communication is presented, alongside an investigation into the decomposition of force and torque components that enable effective human-robot collaboration. To address the inconsistent terminology found in previous literature, a standardized framework for force decomposition is proposed. A new taxonomy is introduced to categorize the force components involved in collaborative manipulation tasks. This taxonomy clarifies the role of each component in an agent's applied force during task execution and provides a structured framework …


Testing And Modeling Of Nonlinearities In Riveted And Bolted Structures, Joshua E. Blackham Apr 2025

Testing And Modeling Of Nonlinearities In Riveted And Bolted Structures, Joshua E. Blackham

Theses and Dissertations

Joints are difficult to model because of various small-scale and nonlinear features, such as local geometry, preload, friction and contact. These features cause a local change in stiffness and energy dissipation which result in changes in the effective natural frequency and damping of the whole structure. Past studies have found good success using nonlinear Iwan elements as whole joint models for bolted joints in a few different structures. In Chapter 3, a similar approach is proposed for modeling riveted joints, which seeks to capture the vibrational response of a test structure including changes in the effective modal frequency and damping …


2025 Scholarly Productivity Report, Missouri University Of Science And Technology Apr 2025

2025 Scholarly Productivity Report, Missouri University Of Science And Technology

Civil, Architectural and Environmental Engineering Scholarly Productivity Reports

No abstract provided.


Wind Collapse Risk And Serviceability Drift Of Steel Concentrically Braced Frame Buildings, Sarah Corrinne Partington Cluff Apr 2025

Wind Collapse Risk And Serviceability Drift Of Steel Concentrically Braced Frame Buildings, Sarah Corrinne Partington Cluff

Theses and Dissertations

Seismic design provisions use the ductility and reserve strength of the lateral structural system to reduce the loads used in design, making the structural design more economical while maintaining life safety. In contrast, current wind design provisions do not. Conventional wind design relies primarily on elastic behavior. The objective of this study is to determine a wind response modification factor for steel concentrically braced frames that could be applied to reduce wind design loads based on ductility and reserve strength, while still meeting drift requirements for serviceability of the structure. To achieve the objective, three types of ductile braced frames …


Steps Towards Effective Human-Robot Co-Manipulation Through Real-Time Modus Detection And Effects Of Stiffness Variation For Human-Soft-Robot Dyads, Shaden Moss Apr 2025

Steps Towards Effective Human-Robot Co-Manipulation Through Real-Time Modus Detection And Effects Of Stiffness Variation For Human-Soft-Robot Dyads, Shaden Moss

Theses and Dissertations

A group of individuals can coordinate very easily to carry a large or heavy object together. This act of collaborative carrying is called co-manipulation. Unlike human teammates, robots cannot easily detect and respond to the intent of human partners during co-manipulation tasks. This shortcoming can be compensated for via the physical design and the software design of robots. This work treats software design with a neural net that detects human modus (or the manner in which a team moves an object together) in real time. This work treats physical design with the use of a soft robot in human-robot co-manipulation, …


Improving Devices To Measure The Thermal Conductivity Of Molten Halide Salts, Ryan J. Ruth Apr 2025

Improving Devices To Measure The Thermal Conductivity Of Molten Halide Salts, Ryan J. Ruth

Theses and Dissertations

Molten salts are of high interest for use in nuclear reactors, though their thermophysical properties are notoriously hard to measure due to the extreme conditions created by them. Significant gaps remain in thermal conductivity and heat capacity data, which this work seeks to fill by improving the Needle Probe-a modified transient hot wire probe originally used by Merritt et al to measure the thermal conductivity of FLiNaK- measuring two new salts, and exploring new materials for use with molten salts. Improvements made to the Needle Probe include automation to reduce human error, more accurate heat generation modeling, a more thorough …


Strength And Ductility Of Rod-Braced Diaphragms In Metal Building Systems Subjected To Earthquake Ground Motions, James Niedens Apr 2025

Strength And Ductility Of Rod-Braced Diaphragms In Metal Building Systems Subjected To Earthquake Ground Motions, James Niedens

Theses and Dissertations

Metal building systems are a common form of construction but the behavior of roof diaphragms in metal buildings that are subjected to earthquake ground motions is not entirely understood. In this study, the strength and ductility of rod-braced diaphragms with hillside washer connections or rod-pad connections was determined using experimental tests and computer simulation. Tensile tests of rods were used to determine the effect of the type of rod on strength and ductility. Two types of rods were tested, full-body rods with cut threads at each end of the rod and bracing rods with rolled threads. Three rod sizes (5/8 …


Hybrid Treatment Method Of Biofiltration Preceded With Advanced Oxidation Process For The Removal Of Emerging Contaminants From The Wastewater Treatment Plant Effluent, Anjali Mohan Payathuparambil Apr 2025

Hybrid Treatment Method Of Biofiltration Preceded With Advanced Oxidation Process For The Removal Of Emerging Contaminants From The Wastewater Treatment Plant Effluent, Anjali Mohan Payathuparambil

Thesis/ Dissertation Defenses

Renewable energy systems face significant challenges in ensuring stability, efficiency, and The global demand for potable quality water has been on a continuous rise. Consequently, water reuse is now considered as an alternative to significantly expand supplies of freshwater in communities facing water shortages. Most of the conventional wastewater treatment plants (WWTP) are not efficient in the removal of emerging contaminants from the water, which will cause serious issues to the environment, human and animal life. This research investigated the possibilities of treating wastewater for reuse. First, the feasibility of utilizing a biofiltration system without pre-treatment for removing emerging contaminants …


Integrating Temperature-Dependent Tissue Properties Into Hifu Computational Models For Enhanced Treatment Planning, Christian Kevin Valencia Narva Apr 2025

Integrating Temperature-Dependent Tissue Properties Into Hifu Computational Models For Enhanced Treatment Planning, Christian Kevin Valencia Narva

Theses and Dissertations

Objective: High-intensity focused ultrasound (HIFU) is a non-invasive therapy that ablates diseased tissues with high precision. Computational simulations using the Pennes Bioheat Transfer Equation (PBTE) can guide HIFU treatment by predicting temperature distributions and thermal dose volumes. Traditional simulations assume constant thermal and acoustic properties, which may oversimplify tissue behavior. Methods: This study evaluates the impact of integrating temperature-dependent thermal properties (thermal conductivity, specific heat capacity, and perfusion) in finite-difference time-domain HIFU simulations. Three scenarios were simulated: (1) a homogeneous liver with both high- and low-power sonications, (2) a rabbit thigh muscle validated against preclinical MRTI data, and (3) an …


Development And Evaluation Of Canbench: A Testbed For Assessing The Security Of Automotive Can Buses, Trevor S. Mcclellan Apr 2025

Development And Evaluation Of Canbench: A Testbed For Assessing The Security Of Automotive Can Buses, Trevor S. Mcclellan

Theses and Dissertations

Modern vehicles rely heavily on electronic control units (ECUs) that communicate via the controller area network (CAN) bus, a protocol developed in the 1980s with minimal security considerations. The growing number of ECUs has heightened the risk of cyberattacks on vehicles. Although CAN bus security has been extensively researched, the CAN standard still lacks built-in security measures. Furthermore, testing proposed security mechanisms is challenging due to the proprietary nature of automotive systems. To address this, an open-source physical testbed was developed using inexpensive, off-the-shelf components to support automotive CAN bus security research. The testbed provides a controlled environment for simulating …


Analysis Of Radial Inlet Distortion On Transonic Fan Performance, Tyler M. Reedy Apr 2025

Analysis Of Radial Inlet Distortion On Transonic Fan Performance, Tyler M. Reedy

Theses and Dissertations

Improving fan design and performance prediction requires an understanding of the impacts of inlet distortions. Inlet distortion describes any non-uniform distribution in the flow, usually referring to deviations in pressure and temperature. Using full annulus Unsteady Reynolds-Averaged Navier Stokes (URANS) simulations, the effects of both hub and tip radial distortions on the Air Force Research Lab (AFRL) Rotor 4 fan are analyzed. Overall performance, total pressure (Pt) distortion transfer, and total temperature (Tt) distortion generation are presented and compared for three operating points: near-stall, design, and choke. Hub radial inlet distortion magnitudes of 15% and 20%, and a tip radial …


Using Human Computation And Harmonic Expansions For Characterization And Design Of Grain Boundary Networks, Christopher W. Adair Apr 2025

Using Human Computation And Harmonic Expansions For Characterization And Design Of Grain Boundary Networks, Christopher W. Adair

Theses and Dissertations

Grain Boundary Networks (GBNs) are a high-dimensional feature in polycrystalline microstructural materials that are formed from the crystallographic degrees of freedom. This feature affects multiple material properties such as diffusivity, fracture, elasticity, heat transfer, and others. The link between the crystallography and the material properties is called the structure-property linkage, and allows for simulation and design of materials. While it is possible to use the structure-property linkage to design materials for better performance, the high-dimensional nature of the interconnected grain boundaries preclude the use of many common optimization algorithms for efficiency or local minima considerations. This work shows how the …


Continuous Purification Of A Parvovirus Using Two Aqueous Two-Phase Extraction Steps, Natalie Nold, Sheridan Waldack, Grace James, Trisha Colling, Lynn M. Manchester, Taravat Sarvari, Amanda P. Bekkala, Seth Kriz, Madison Baldwin, Emily Agustin-Mazariegos, Michael J. Betenbaugh, Caryn Heldt Apr 2025

Continuous Purification Of A Parvovirus Using Two Aqueous Two-Phase Extraction Steps, Natalie Nold, Sheridan Waldack, Grace James, Trisha Colling, Lynn M. Manchester, Taravat Sarvari, Amanda P. Bekkala, Seth Kriz, Madison Baldwin, Emily Agustin-Mazariegos, Michael J. Betenbaugh, Caryn Heldt

Michigan Tech Publications

Aqueous two-phase systems (ATPS) are a liquid–liquid extraction method that offers low-cost, continuous-adaptable virus purification. A two-step ATPS using polyethylene glycol (PEG) and sodium citrate that recovered 66% of infectious porcine parvovirus with 2.0 logs of protein removal and 1.0 logs of DNA removal in batch has now been run continuously. The continuous system output of < 10 ng/mL DNA regardless of starting DNA titer agreed with batch studies. However, the continuous system had a five-fold higher contaminating protein titer than batch studies, likely because of incomplete mixing or settling. Turbidity was tested as a measure of mixing and settling efficiency. Monitoring in-line absorbance at 880 nm directly after mixing and before collection in the settling reservoir could track both mixing and settling during operation. Settling time was reduced by changing the settling line material from PVC to PTFE, which is more hydrophobic. A flow-through AEX filter tested to make impurity removal more robust recovered 90% of PPV and removed an additional 87% of host cell DNA. The filter did not add any additional protein removal. In the future, in-line absorbance sensors could be implemented along with conductivity sensors to measure salt concentration, refractive index sensors to track the PEG-citrate interface, and scales to track mixer and reservoir volumes to enable automated, continuous ATPS. Our vision is to integrate continuous ATPS into a fully continuous end-to-end production for viral vectors.


The National Cybersecurity Teaching Coalition: Expanding Cybersecurity Education Opportunities, Paul Wagner, Melissa Dark, Robert Honomichl, Filipo Sharevski, Sandra Leiterman Apr 2025

The National Cybersecurity Teaching Coalition: Expanding Cybersecurity Education Opportunities, Paul Wagner, Melissa Dark, Robert Honomichl, Filipo Sharevski, Sandra Leiterman

Journal of Cybersecurity Education, Research and Practice

The increasing prevalence of cybersecurity threats and the shortage of qualified professionals necessitate innovative solutions for cybersecurity education at all levels. Despite the expansion of post-secondary cybersecurity programs, employer dissatisfaction with graduates and a lack of standardized introductory curricula highlights the need for structured secondary education pathways. The National Cybersecurity Teaching Coalition (NCTC) and its National Cybersecurity Teaching Academy (NCTA) address this gap by equipping high school educators with the necessary knowledge and credentials to teach cybersecurity effectively. NCTA offers an 18-credit cybersecurity graduate certificate program to ensure teachers are competent and confident to develop and teach cybersecurity curriculum with …


Unleaded Aviation Fuel: Assessing Stakeholder Perceptions And Preparing An Organization For Change, Ryan Guthridge, Nicholas D. Wilson, Brandon Wild Apr 2025

Unleaded Aviation Fuel: Assessing Stakeholder Perceptions And Preparing An Organization For Change, Ryan Guthridge, Nicholas D. Wilson, Brandon Wild

Journal of Aviation Technology and Engineering

Since the Clean Air Act of 1996 banned the use of leaded fuel for automotive applications, leaded aviation gasoline (AVGAS) has become one of the leading sources of lead pollution in the nation due to the volume of AVGAS consumed in general aviation applications (GAMA, 2019). The Federal Aviation Administration has recently recognized this concern with the establishment of the Eliminate Aviation Gasoline Lead Emissions (EAGLE) initiative, which was formally established in February 2022 to foster an important campaign to research and inform the general aviation community on the process for transitioning to unleaded AVGAS. This essay seeks to inform …


Enhancing Organizational Resilience Through Fatality Prevention At Vulcan Materials Company, Ross Boeker Apr 2025

Enhancing Organizational Resilience Through Fatality Prevention At Vulcan Materials Company, Ross Boeker

ASEM Capstones

2025 ASEM 620 Capstone Project


An Analysis Of The Encryption Algorithms Proposed For The Mqtt Protocol On Resource Constrained Iot Devices, John Joseph Keenan Apr 2025

An Analysis Of The Encryption Algorithms Proposed For The Mqtt Protocol On Resource Constrained Iot Devices, John Joseph Keenan

Theses and Dissertations

As more IoT devices are used to gather data and automate devices throughout the world, more security solutions are needed to keep these devices and the data they transmit secure. Many of these devices use the MQTT protocol, which does not encrypt the transferred data by default. The TLS/SSL protocols are the standard proposed solution for encrypting this traffic, but many resource constrained IoT devices do not have enough resources to run these protocols efficiently. Because of this, many other encryption algorithms have been proposed or designed for resource constrained IoT devices running the MQTT protocol, but very limited research …


The Development Of Electroanalytical Methods For Molten Salt Mixtures Under Static And Flowing Conditions, Ranon Fuller Apr 2025

The Development Of Electroanalytical Methods For Molten Salt Mixtures Under Static And Flowing Conditions, Ranon Fuller

Theses and Dissertations

Electroanalytical methods have the potential to characterize molten salt systems in situ, determine physical properties such as diffusion coefficients and standard potentials, and measure kinetic and corrosion rates. Due to experimental difficulties of working with molten salts including high temperatures and high natural convection, transport, kinetic, and corrosion rates, many precise, consistent methods have yet to be established. In this work, we describe methods to precisely calculate standard reduction potentials, characterize molten salt solutions containing multiple lanthanides by reduction potentials and metal deposition mechanisms, calculate the number of electrons exchanged in metal deposition using SWV, calculate diffusion coefficients using CV, …