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Cellular Telemetry For Real-Time River Flow Velocity Data From Fluvial Acoustic Tomography Loggers, Joshua Lee Seymour May 2025

Cellular Telemetry For Real-Time River Flow Velocity Data From Fluvial Acoustic Tomography Loggers, Joshua Lee Seymour

Honors Theses

Streamflow is a critical element in understanding watershed processes and the effects of land use on those processes because it is the primary medium through which water, sediment, nutrients, organic material, thermal energy, and aquatic species move. Fluvial Acoustic Tomography (FAT) systems offer accurate direct measurements of river section-averaged flow velocity by measuring reciprocal acoustic travel times between at least two acoustic nodes positioned on opposite riverbanks. However, similar to many in-situ sensors used in estuarine and riverine environments, FAT loggers require manual data retrieval, which is time-consuming, labor-intensive, and limits real-time access and increases maintenance costs. This project presents …


Development And Characterization Of A Pro-Angiogenic Peptide Amphiphile For Deep Dermal Burn Healing Via Spray Delivery, Loria Dimartino May 2025

Development And Characterization Of A Pro-Angiogenic Peptide Amphiphile For Deep Dermal Burn Healing Via Spray Delivery, Loria Dimartino

Honors Theses

Severe burns and other dermatological injuries are frequently accompanied by a range of comorbidities and aesthetic challenges that patients must contend with. The complexity of burn care is exacerbated by the lack of a standardized surgical protocol, as treatment strategies are tailored to individual patient factors, including overall health status, wound size and location, as well as the expertise and resources available to the surgical team. Most commonly, deep dermal burns are treated through grafting, which effectively covers the injury site, but requires the creation of a second wound on the body of approximately the same size. This produces a …


Surface Vortex Mitigation At Submerged Intakes, Camren Todd May 2025

Surface Vortex Mitigation At Submerged Intakes, Camren Todd

All Graduate Theses and Dissertations, Fall 2023 to Present

Surface vortices at submerged intakes entrain air, convey debris, and reduce efficiency. This research investigates the effect of lid geometry on mitigation of surface vortices at submerged intakes in the context of still reservoirs. Six lid geometries were evaluated: three solid lids of increasing diameter, two lids with perforations, and one lid fitted with a downward curtain. Vortex severity was measured by Alden’s vortex type rating scale, surface-dimple diameter, and qualitative video analysis.

The perforated lid extension and the curtain configurations were most effective at mitigating vortices. The curtain configuration negated all surface swirling by redirecting a portion of the …


Game Changing Education: Empowering High School Stem Teachers To Teach Engineering Using Games, Leslie Brown May 2025

Game Changing Education: Empowering High School Stem Teachers To Teach Engineering Using Games, Leslie Brown

All Graduate Theses and Dissertations, Fall 2023 to Present

In response to the Next Generation Science Standards (NGSS) released in 2013, there was a nationwide push for K-12 schools to include engineering concepts in science classrooms. However, there is an overall lack of teacher preparedness and training towards engineering topics as shown by common engineering misconceptions. To improve this issue, I initiated a qualitative study to describe the strategies and attitudes of high school science, technology, engineering, and mathematics (STEM) teachers that have implemented game-based, engineering activities into their classroom. Game-based learning is an instructional framework that utilizes game-like elements in a classroom and was used in this study …


Strategies For Increasing Methane Removal In Methanotroph Bench-Scale Systems For The Production Of Ectoine, Jaden Storrer May 2025

Strategies For Increasing Methane Removal In Methanotroph Bench-Scale Systems For The Production Of Ectoine, Jaden Storrer

All Graduate Theses and Dissertations, Fall 2023 to Present

Anthropogenic methane emissions contribute to the greenhouse gas profile which is the chief cause of climate change. One significant source of methane emissions is biogas produced from bacteria in wastewater facilities and landfills. Methane rich biogas has the potential to be valorized into high value bioproducts by using methanotrophs (microbes that use methane as their primary carbon source). Methylotuvimicrobium alcaliphilum 20Z was selected for this study as it can generate ectoine when grown in highly saline environments. Ectoine has been proven to have many benefits such as it prevents protein denaturation, it has hydration properties, and is a UV protectant. …


Effects Of Light Intensity On Algae Biofilms In Rotating Algae Biofilm Reactors (Rabr), Joshua D. Wintch May 2025

Effects Of Light Intensity On Algae Biofilms In Rotating Algae Biofilm Reactors (Rabr), Joshua D. Wintch

All Graduate Theses and Dissertations, Fall 2023 to Present

There is a growing need for economically and ecologically friendly wastewater treatment processes. Utilizing natural algae biofilms to remediate excess nitrogen and phosphorus from municipal wastewater is a treatment technique of academic interest. Utilizing natural algae in rotating algae biofilm reactors (RABR) is a potential engineering application of algae biofilms for municipal wastewater anaerobic digestor effluent treatment. The ideal reactor operation would use sunlight as the light source for algae growth, however, there is little academic research on algae biofilm growth productivity across natural sunlight light intensity ranges. This research seeks to understand the relationship between rotating algae biofilm reactor …


Kinetic Growth Rate Analysis Of Coelastrella Sp. In Aquaculture Wastewater., Rob Skarvan May 2025

Kinetic Growth Rate Analysis Of Coelastrella Sp. In Aquaculture Wastewater., Rob Skarvan

Master of Engineering Theses

The demand for sustainable food and energy production continues to rapidly rise. Utilizing aquaculture wastewater as microalgae growth medium is a potential opportunity for nutrient recycling and industrial symbiosis, but more research is required to understand how best to design and scale-up a dual-purpose facility. This study investigates the growth of Coelastrella sp. in aquaculture wastewater compared to industry-standard growth medium BG-11 and modified tap water as controls. Though cell size and pigment density varied throughout media, aquaculture wastewater performed very comparably to BG-11 as a microalgae culture broth.

The Monod equation can model Coelastrella sp. growth based …


Enhancing Patient Safety: Exploring Virtual Sitters' Role In Fall Prevention Through Remote Virtual Monitoring, Adama Diallo, Awatef Ergai Dr., Leeanna Spiva Dr., Meriel Mccollum Dr. Apr 2025

Enhancing Patient Safety: Exploring Virtual Sitters' Role In Fall Prevention Through Remote Virtual Monitoring, Adama Diallo, Awatef Ergai Dr., Leeanna Spiva Dr., Meriel Mccollum Dr.

Symposium of Student Scholars

Remote Virtual Monitoring (RVM) technology enhances safety for both patients and care teams by reducing falls, improving the efficiency and effectiveness of continuous patient observation, and lowering costs associated with falls and staff support. The success of fall reduction efforts largely depends on the role of virtual sitters, individuals who remotely monitor high-risk patients to prevent falls. This study aims to explore the experiences of virtual sitters, identifying key themes, challenges, and opportunities to improve the intervention. Specifically, the research investigates how technology, work shifts, and institutional support impact the effectiveness and job satisfaction of virtual sitters.


Deep Learning Algorithms For Traffic Flow Predictions, Adegoke Ojeniyi, Prince Pal Singh, Ankita Vashisht, Swati Kumari, Karan Karan Apr 2025

Deep Learning Algorithms For Traffic Flow Predictions, Adegoke Ojeniyi, Prince Pal Singh, Ankita Vashisht, Swati Kumari, Karan Karan

AUIQ Technical Engineering Science

Given the growing complexity of urban transportation systems, precise traffic flow forecasting is essential for reducing not only issues of congestion but also, for boosting road safety and enhancing mobility management. This study integrates Convolutional Neural Network-Long Short-Term Memory (CNN-LSTM), Long Short-Term Memory (LSTM), and Recurrent Neural Networks (RNN) to present a hybrid deep learning framework for traffic prediction. Of these, the CNN-LSTM model is a reliable option for real-time traffic forecasting since it successfully captures both spatial and temporal dependencies, resulting in superior predictive performance. The dataset used to assess the framework includes 48,120 records from a traffic monitoring …


Improving Image Quality In Electrical Capacitance Tomography Using Otsu Thresholding, Josiah Nombo Apr 2025

Improving Image Quality In Electrical Capacitance Tomography Using Otsu Thresholding, Josiah Nombo

Tanzania Journal of Engineering and Technology (TJET)

Electrical Capacitance Tomography (ECT) is an imaging technique used in industrial process monitoring, particularly for monitoring and measuring the composition of multiphase flows. Despite its widespread application, the commonly used Linear Back Projection (LBP) algorithm often produces low-quality images due to its limited ability to handle high permittivity contrasts and nonlinearities. This study investigates the use of Otsu thresholding as a post-processing technique to enhance ECT image quality. By maximizing inter-class variance in the image histogram, Otsu thresholding improves contrast, clarity, and structural definition, enabling more effective segmentation of oil and gas components in multiphase flows. The proposed Otsu-based reconstruction …


Design And Performance Analysis Of Fiber Bragg Grating Temperature Sensor For Industrial Processes Sensing Applications, Paul Stone Stone Brown Macheso S.B. Apr 2025

Design And Performance Analysis Of Fiber Bragg Grating Temperature Sensor For Industrial Processes Sensing Applications, Paul Stone Stone Brown Macheso S.B.

Tanzania Journal of Engineering and Technology (TJET)

The Fiber Bragg Grating (FBG) sensor has become a widespread sensing device because of its small size, passive design, immunity to electromagnetic interference, and direct ability to measure physical properties like temperature and strain. Recently, femtosecond infrared laser processing and regeneration techniques have resulted in the development of stable high-temperature gratings, which are a powerful tool in smart factories, an aspect of the fourth Industrial Revolution (4IR), and show promise for application in harsh environments like high pressure, high temperature, or ionizing radiation. The development of stable high-temperature gratings that can withstand harsh environmental factors like high temperatures, pressures, and …


Detection Of Http Flood Attacks Based On Machine Learning Algorithms, Norbek Karimov, Furkat Rakhmatov, Oybek Xolmuminov Apr 2025

Detection Of Http Flood Attacks Based On Machine Learning Algorithms, Norbek Karimov, Furkat Rakhmatov, Oybek Xolmuminov

Chemical Technology, Control and Management

This paper analyzes the effectiveness of Random Forest and SVM models for detecting HTTP Flood attacks. Experimental results demonstrate that both models achieve high accuracy. Evaluation was conducted using Precision, Recall, and F1 Score metrics. Additionally, key features of network traffic were extracted through correlation analysis to enable real-time application of the models in attack detection. The findings provide important insights into detecting DDoS attacks using machine learning and improving model performance.


Power-Beaming: Wireless Energy Transfer Using Lasers, Spencer L. Barnett Apr 2025

Power-Beaming: Wireless Energy Transfer Using Lasers, Spencer L. Barnett

ATU Scholars Symposium

The objective of the project is to implement a wireless energy transfer system utilizing laser technology. This system involves modulating the laser’s beam profile and spatial distribution through precise optical manipulation. The energy transmitted by the laser is captured by a photovoltaic array, commonly referred to as a solar panel, which is engineered to convert incident photons into direct current (DC) electrical power. The current challenge is to develop a reliable wireless energy transfer mechanism capable of operating over extended distances, thereby overcoming the constraints imposed by wired connections, particularly in environments where wiring is impractical, such as in space. …


Dust Analyses In Ventilation Ducts, Karolina Vyhlidalova, Petr Vlček, Olga Rubinová, Jiří Bernard Apr 2025

Dust Analyses In Ventilation Ducts, Karolina Vyhlidalova, Petr Vlček, Olga Rubinová, Jiří Bernard

Journal of Sustainable Construction Materials and Technologies

The paper describes the importance of monitoring the dust in the atmosphere of human life. It deals with the issue of dust in air ducts, approaching the methods that can be used to detect the amount of dust. For conditions for buildings in the Czech Republic there is created the methodology of quantitative and qualitative evaluation of dust sediment for the needs of HVAC and other building surfaces. The scale for visual evaluation was created and it has been elaborated the assessment of kind of particles contained in dust.


Assessment Of Long Time Approximation Equation To Determine Thermal Conductivity Of High Porous Materials With Nss Probe, Hussein Humaish, Bastien Ruet, Laurent Marmoret, Hassen Beji Apr 2025

Assessment Of Long Time Approximation Equation To Determine Thermal Conductivity Of High Porous Materials With Nss Probe, Hussein Humaish, Bastien Ruet, Laurent Marmoret, Hassen Beji

Journal of Sustainable Construction Materials and Technologies

Recent economic changes have increased the focus on energy conservation in buildings. Improve insulation represents one of the biggest challenge to save energy. The TP02 Huksefux® Non Steady State Probe (NSSP) has been used to determine the thermal conductivity of the building insulation materials. Usually, the long term approximation equation (linear form) is applied to determine the thermal conductivity when using hot wire techniques. Long term approximation has been successfully used to characterize glycerol: a fluid which doesn’t present contact resistance and porosity. But, an S-shaped appears for more porous materials. So to generalize the possibility of using this method, …


Enhancing Embankment Dam And Levee Resilience Against Overtopping Erosion: The Muscatine Island Levee Project, W. R. Thompson, J. T. Leyh Apr 2025

Enhancing Embankment Dam And Levee Resilience Against Overtopping Erosion: The Muscatine Island Levee Project, W. R. Thompson, J. T. Leyh

5th International Seminar on Dam Protections Against Overtopping

HydroTurf® is an advanced revetment solution engineered to protect embankment dams and riverine levees from erosion caused by overtopping events. Its design provides an impermeable geomembrane protected by engineered turf with a high strength cementitious infill, resulting in a fiber reinforced high-strength concrete matrix. The system provides a durable and impermeable barrier against erosive forces.

The Muscatine Island Levee Improvement Project, situated along the Mississippi River in Iowa, exemplifies the application of HydroTurf. This initiative aimed to enhance flood protection for approximately 30,000 acres of commercial, industrial, and residential areas. A critical component was the construction of a hardened controlled …


Analyzing The Chemical Composition & Morphology Of Hydroxyapatite Coating On Magnesium Biomaterials, Khaoula Kamal Apr 2025

Analyzing The Chemical Composition & Morphology Of Hydroxyapatite Coating On Magnesium Biomaterials, Khaoula Kamal

Honors Theses

The purpose of this thesis is to further explore the capabilities of magnesium metal to serve in biodegradable orthopedic implant applications. Current standards for orthopedic implants involve metals that cause many issues such as high risk of infection due to the need for secondary surgery. Despite magnesium’s biocompatibility, it presents a challenge that will be addressed in this thesis: a fast degradation rate. To combat this problem, hydroxyapatite (HA), an integral component of bone, was used to coat the surface of magnesium scaffolds and offer a slower degradation rate. Previous Priddy Lab studies have confirmed the presence of HA coating …


An Empirical Evaluation Of Communication Technologies And Quality Of Delivery Measurement In Networked Microgrids, Ruairí De Fréin, Yasin Emir Kutlu Apr 2025

An Empirical Evaluation Of Communication Technologies And Quality Of Delivery Measurement In Networked Microgrids, Ruairí De Fréin, Yasin Emir Kutlu

Articles

Networked microgrids (NMG) are gaining popularity as an example of smartgrids (SG), where power networks are integrated with communication technologies. Communication technologies enable NMGs to be monitored and controlled via communication networks. However, ensuring that communication networks in NMGs satisfy quality of delivery (QoD) metrics such as the round trip time (RTT) of NMG control data is necessary. This paper addresses the communication network types and communication technologies used in NMGs. We present various NMG deployments to demonstrate real-life applicability in different contexts. We develop a real-time NMG testbed using real hardware such as Cisco 4331 Integrated Services Routers (ISR). …


Netflix : D’Une Digitalisation Cinématographique Vers Une Déconstruction Du 7èMe Art, Karim El Mahjoubi Apr 2025

Netflix : D’Une Digitalisation Cinématographique Vers Une Déconstruction Du 7èMe Art, Karim El Mahjoubi

Dirassat

According to a study conducted by GroupM1, 76% of French people have gone to the cinema less since the 2018 health crisis. The first reason given is "the fear of being contaminated by Covid-19". This is how the streaming platform "Netflix" saw, here, a godsend to seize this market and innovate in cinematographic digitalization. It therefore decided to rent via a monthly subscription, through a Smartphone or Smart TV application, films and series to watch "without moderation" (unlike the old video clubs). The cinema then becomes "Smart or pocket" and accessible, at a low price, for any film buff because …


Les Droits D’Auteur À L’Ère De La Révolution Numérique : Enjeux Et Perspectives, Ismail Madani Alaoui, Said Ouhamou, Mohamed Boukhch Apr 2025

Les Droits D’Auteur À L’Ère De La Révolution Numérique : Enjeux Et Perspectives, Ismail Madani Alaoui, Said Ouhamou, Mohamed Boukhch

Dirassat

This article explores the challenges and issues associated with the development of digital technologies in the context of copyright law. The authors examine significant changes in the creation, distribution, and consumption of digital content, as well as the consequences for copyright holders. Our article focuses on different approaches to copyright protection in the digital environment, such as DRM licenses and Creative Commons. It also evaluates their effectiveness in protecting creators' rights while promoting access to works. The issue of piracy and illegal sharing of digital content is also addressed, as well as the measures taken by the government and industry …


Comment La Digitalisation Affecte-T-Elle Les Interactions Sociales, Culturelles Et Économiques Au Maroc ?, Redouane El Majdouli Apr 2025

Comment La Digitalisation Affecte-T-Elle Les Interactions Sociales, Culturelles Et Économiques Au Maroc ?, Redouane El Majdouli

Dirassat

This study explores the multidimensional impact of digitalization on social, cultural, and economic interactions in Morocco. By leveraging modernization and social network theories, the analysis reveals how digital technologies transform social dynamics, facilitate innovation, and pose challenges in terms of access inequalities and privacy protection. Using a mixed- method approach combining quantitative surveys and qualitative analyses, the results show a growing adoption of digital technologies and their varied effects on Moroccan society. The proposed recommendations aim to maximize the benefits of digitalization while minimizing its risks, contributing to sustainable and inclusive development.


Impact Des Plateformes De Streaming Sur Les Métiers De La Scène, Ismail Madani Alaoui, Mourad Oumzi, Abdessamad Boulkhalil Apr 2025

Impact Des Plateformes De Streaming Sur Les Métiers De La Scène, Ismail Madani Alaoui, Mourad Oumzi, Abdessamad Boulkhalil

Dirassat

This article examines the impact of streaming platforms, particularly Netflix, on performing arts professions. It explores how Netflix has transformed production practices, distribution methods, and modes of reception for artistic performances. By redefining accessibility, integrating advanced technologies, and offering alternative financing models, Netflix has created a dynamic and inclusive environment for artists and audiences. The challenges and opportunities related to these transformations are also analyzed, including the emergence of new economic models and their long- term viability for the entertainment industry. The article highlights the profound implications of these changes for artists, cultural institutions, and global audiences


L'Utilisation Des Technologies Numériques Dans Les Musées Contemporains Au Maroc : Les Défis De La Préservation Culturelle, De L'Accès Et De La Justice Dans L'Utilisation De La Réalité Virtuelle Et Augmentée, Fadma Fangach Apr 2025

L'Utilisation Des Technologies Numériques Dans Les Musées Contemporains Au Maroc : Les Défis De La Préservation Culturelle, De L'Accès Et De La Justice Dans L'Utilisation De La Réalité Virtuelle Et Augmentée, Fadma Fangach

Dirassat

This study investigates the impact of immersive technologies, particularly Virtual Reality (VR) and Augmented Reality (AR), on visitor experiences at two distinct museums: the Museum of Modern and Contemporary Art Mohamed the Sixth and the Exhibition and Museum of the Prophet’s Biography and Islamic Civilization. Employing a qualitative approach and a comparative case study methodology, the research examines the employment of VR and AR within each museum, focusing on their respective modes of projection and exhibition. While the Museum of Modern and Contemporary Art Mohamed the Sixth uses VR to establish a virtual space online, the Exhibition and Museum of …


L'Appel Du Rupestre Land : Revisiter L’Art Rupestre En Le Numérisant, Ghizlane Assif, Abdelkrim M’Hammed Oubella Apr 2025

L'Appel Du Rupestre Land : Revisiter L’Art Rupestre En Le Numérisant, Ghizlane Assif, Abdelkrim M’Hammed Oubella

Dirassat

This article attempts to explore the use of digital technology in preserving Moroccan rock art, emphasizing the significance of this art form in understanding the history and culture of our ancestors through digital tools such as 3D modeling, virtual reality, and others. This digitization effort aims to document and safeguard these cultural treasures while making them accessible to the public. The objective of the article is to examine the potential of digitizing rock art in our documentary film, "The call of the rupestre- land" We aimed to contribute to the digital conservation of heritage through audiovisual means. Indeed, this modest …


Numérisation Des Œuvres D’Art : L’Exemple Du Musée Numérique De La Micro-Folie, Meriem Benmhamed Apr 2025

Numérisation Des Œuvres D’Art : L’Exemple Du Musée Numérique De La Micro-Folie, Meriem Benmhamed

Dirassat

Digitization refers to the creation of a digital copy of a text, image or other object. And if we make a copy of something, it's often to prevent its waste. It's a process which look like photocopying. We can digitize or scan silver photos, for example, to save them digitally or publish them online. In the art world, digitization makes it possible to save certain works of art from oblivion and deterioration. Paradoxically, it saves them, while at the same time falsifying them.

Until recently, the concept of an archive was something tangible and material, but now we're talking more …


La Mise En Visibilité Pratiquée Par/Sur Les Réseaux Socionumériques (Rsn) : Identité Numérique Et Motivations D’Usage Cas Des Jeunes Artistes En Développement D’Agadir En Art Visuel, Abderrahmane Ait Rahou, Nadia Bouaafia, Zohra Zemmit Apr 2025

La Mise En Visibilité Pratiquée Par/Sur Les Réseaux Socionumériques (Rsn) : Identité Numérique Et Motivations D’Usage Cas Des Jeunes Artistes En Développement D’Agadir En Art Visuel, Abderrahmane Ait Rahou, Nadia Bouaafia, Zohra Zemmit

Dirassat

The objective of this article is to present the results of a qualitative study conducted with around ten artists. The issue addressed is as follows: How are the practices of young artists affected by the visibility carried out by/on social networking sites (SNS)? We start from the premise that an artist's relationship with SNS should be viewed not as a given, but as a construct subject to the influence of factors both intrinsic and extrinsic to the artist. Theoretically, we consider that the sociology of uses provides a suitable analytical framework to frame the normativity of this digital environment alongside …


Design Et Intelligence Artificielle : Esquisse D’Une Logique De Créativité Générative Artificielle, Nada Ouerghi Apr 2025

Design Et Intelligence Artificielle : Esquisse D’Une Logique De Créativité Générative Artificielle, Nada Ouerghi

Dirassat

This article questions the creative process in design compared with that of generative artificial intelligence (GAI), and attempts to define a relationship between creative and generative logic.

As a result, a resonance between the design mindset and AGI is identified, thanks to the poetics and use of the design toolbox borrowed to GAI .

Creative cogeneration reconciles human and machine. But the logic of artificial imagination led to question the future of the designer's profession and calls for a mandatory updating of the designer's profile!


Team Safe Skies: Project Talon Interceptor, Cole Carlson, Peter Dinh, Sebastian Gomez, Alex Widner Apr 2025

Team Safe Skies: Project Talon Interceptor, Cole Carlson, Peter Dinh, Sebastian Gomez, Alex Widner

Senior Design Project For Engineers

This report aims to lay out our design process for the missile interceptor aircraft. Our Talon Interceptor is an inexpensive, scaled-down, autonomous F-16 for mass production. The aircraft can ascend quickly for mission requirements while avoiding detection with its internal weapons bay. Multiple decisions have been made to ensure the initial and maintenance costs are reasonable without compromising the missions. TOPSIS reviews have been used to measure significant components unbiasedly and objectively. Our aircraft meets all the AIAA requirements while coming in under budget.


A Survey Of Acoustic Phenomena And Predictive Modeling Techniques For High Explosive Experimentation, Nathanael I. Breed Apr 2025

A Survey Of Acoustic Phenomena And Predictive Modeling Techniques For High Explosive Experimentation, Nathanael I. Breed

Senior Honors Theses

High explosive experimentation (HEE) is a technical industry that is regulated, expensive, and dangerous. Developing novel technologies to aid in predictive abilities to minimize the industry’s reliance on the need for full-scale experiments is a worthwhile endeavor. Having the capacity to make accurate predictions regarding the overpressure of a detonation wave after it has interacted with various geometries is useful, but the current state of predictive techniques is limited with many techniques, either neglecting relevant acoustic phenomena or not being able to account for complex geometries. This thesis provides an overview of several acoustic phenomena and the current state of …


Quantifying Treatment Response To A Macrophage-Targeted Therapy In Combination With Immune Checkpoint Inhibitors After Exposure To Conventional Chemotherapy, Shelby N. Bess, Gaven K. Smart, Timothy J. Muldoon Apr 2025

Quantifying Treatment Response To A Macrophage-Targeted Therapy In Combination With Immune Checkpoint Inhibitors After Exposure To Conventional Chemotherapy, Shelby N. Bess, Gaven K. Smart, Timothy J. Muldoon

Biomedical Engineering Faculty Publications and Presentations

Background: Conventional chemotherapeutic agents, such as 5-fluorouracil (5-FU), can exert anti-tumor effects through immunogenic cell death (ICD) induction. Researchers have found hallmarks that quantify ICD (such as the translocation of HMGB1 and calreticulin). Although chemotherapeutic agents can induce ICD, they increase the expression of immune checkpoints, limiting their effectiveness. Studies have emphasized the importance of investigating the heterogeneous responses of cells co-localized in a solid tumor (macrophages, tumor cells, etc.) to ICD induction. However, these studies were performed in vivo, which limits the collection of information on cell-cell interactions due to model complexity.

Methods: In this study, we used a …