Digital Commons Network^™

Selection Methods For Genetically-Modified T Cells: In Support Of Translational Therapy, David Rushworth

Dissertations and Theses (Open Access)

T cells are blood cells which organize the immune system of the host. These cells are necessary for the host to respond appropriately to threats from foreign organisms and cancerous growth. However, in the case of certain infections and cancer, T cells are unable to respond appropriately to a threat and establish immunity. This leads to disease when the infection or cancer is not sufficiently eliminated. On the other hand, T cells can lack tolerance for healthy tissue and perceive healthy tissue as infected. The ensuing over-reactive immune response also leads to disease. A delicate balance must exist between immunity …

Prioritizing Interdictions On A Shortest Path Network, Hayden D. Summerhill

Industrial Engineering Undergraduate Honors Theses

We consider a variant to the shortest path network interdiction problem with symmetric information from Israeli and Wood (Networks 40, 97-111,2002) which arises in the context of nuclear smuggling prevention. In the basic shortest path interdiction problem, an interdictor has a limited number of interdictions with which he can lengthen arcs in a network in order to maximize the length of the network’s shortest path. This thesis considers the case in which the interdictor does not make all of the interdictions at once. Rather, the interdictor must make the interdictions over a set number of periods. Each period has a …

14th Annual Undergraduate Student Symposium, Farquhar Honors College

Undergraduate Student Symposium

The Undergraduate Student Symposium, sponsored by the Farquhar College of Arts and Sciences, presents student projects through presentations, papers, and poster displays. The event serves as a “showcase” demonstrating the outstanding scholarship of undergraduate students at NSU. The symposium is open to undergraduate students from all disciplines. Projects cover areas of student scholarship ranging from the experimental and the applied to the computational, theoretical, artistic, and literary. They are taken from class assignments and independent projects. The projects do not have to be complete; presentations can represent any stage in the concept’s evolution, from proposal and literature review to fully …

Modeling Person-To-Person Contaminant Transport In Enclosed Environments, Chun Chen

Open Access Dissertations

It is essential to predict person-to-person contaminant transport in enclosed environments to improve air distribution design and reduce the infection risk from airborne infectious diseases. This study aims to improve and accelerate the simulation of person-to-person contaminant transport in enclosed environments. ^ This investigation first conducted experimental measurements of person-to-person contaminant transport in an office mockup and the first-class cabin of a functional MD-82 aircraft. The experimental data of steady-state airflow, temperature, and gas contaminant concentration fields obtained in the office were used to validate the steady-state computational fluid dynamics (CFD) models. In the aircraft cabin, the transient particle concentrations …

Controlled Rest In Position (Crip): Consumer Perceptions In The United States, Scott R. Winter, Jason Carryl, Stephen Rice

Publications

Controlled rest in position (CRIP) has been suggested as a viable countermeasure to the Federal Aviation Administration (FAA) in the ongoing efforts to combat in-flight pilot fatigue. It is already in use in other parts of the world; however, it is not currently permitted in the United States. While expert opinion suggested it poses little threat to flight safety, with valuable returns in terms of improved crew alertness and performance, there is some doubt about the level of consumer buy-in. This study completed a preliminary investigation into overall consumer willingness to fly, in the use of CRIP procedures in the …

Solids Accumulation Rates Of Latrines At Rural Schools In Nimba County, Liberia, Caraline M. Murphy

USF Tampa Graduate Theses and Dissertations

Access to appropriate sanitation facilities as well as access to clean drinking water are considered fundamental human rights (Carr, 2001; Bjorklund & Sjodin, 2010), yet roughly 2.5 billion people on the planet lack access to an improved form of sanitation (WHO/UNICEF, 2014). Additionally, many entities responsible for emergency excreta management and sanitation management design guidelines, specifically solids accumulation rates in latrine pits, use rates that are 30-60 years old and may be established from dated knowledge on diet and lifestyle trends (Franceys et al., 1992; Harvey et al., 2002; Harvey, 2007). Using solids accumulation rates that are dated as well …

Session 2c, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Investigating the Recent Invasion of Silver Carp (Hypopthalmicthys molitrix) into Kentucky Lake, Utilizing Diet and Long Term Data Analysis, Ben Tumolo and Michael B. Flinn, Hancock Biological Station, Murray State University, Murray, KY
• Assessment of Chytrid Fungus (Bactrachochytrium dendrobatidis) Occurrence and Prevalence in Plethodontid Salamanders Across a Forest Disturbance Gradient in Southeastern Kentucky, Sarah M. Hamilton and others, Forestry Department, University of Kentucky, Lexington, KY
• Strain Diversity in the Fecal Indicator Escherichia coli: Implications for its Use as a Produce Pathogen Surrogate, Ethan Givan and others, USDA-ARS, Bowling Green, KY

Towards Sustainability In The Oil And Gas Sector: Benchmarking Of Environmental, Health, And Safety Efforts, Jennifer Schneider, Salim Ghettas, Nacer Merdaci, Mervin Brown, Joseph Martyniuk, Waleed Alshehri, Anthony Trojan

Journal of Environmental Sustainability

The environmental, social and climate change issues that face the world today have all industries considering how they will address sustainability in the future. The purpose of this paper is to evaluate the maturity of environmental, health and safety (EHS) efforts and progress toward sustainability in the oil and gas sector. Ten major oil companies have been analyzed based on public information including their published annual reports. Companies refer to voluntary initiatives when reporting their performance yet the assessment suggests that the sector overall continues to make progress and is maturing in its sustainability efforts. Many management system gaps were …

Transcriptional Network Growing Models Using Motif-Based Preferential Attachment, Ahmed F. Abdelzaher, Ahmad F. Al-Musawi, Preetam Ghosh, Michael L. Mayo, Edward J. Perkins

Computer Science Publications

Understanding relationships between architectural properties of gene-regulatory networks (GRNs) has been one of the major goals in systems biology and bioinformatics, as it can provide insights into, e.g., disease dynamics and drug development. Such GRNs are characterized by their scale-free degree distributions and existence of network motifs – i.e., small-node subgraphs that occur more abundantly in GRNs than expected from chance alone. Because these transcriptional modules represent “building blocks” of complex networks and exhibit a wide range of functional and dynamical properties, they may contribute to the remarkable robustness and dynamical stability associated with the whole of GRNs. Here, we …

09. Environmental Science, Northeastern State University

Oklahoma Research Day Abstracts

No abstract provided.

Evaluating The Potential For Passive Greywater Irrigation In Northern Ghana, Chelsea L. Fagan

Dissertations, Master's Theses and Master's Reports - Open

Water scarcity, malaria, and malnutrition are all concerns facing the people of Chirifoyili and the Northern Region of Ghana. Greywater pooling outside of homes increases human exposure to pathogens and provides breeding grounds for disease carrying insects, especially malaria spreading mosquitoes. This project looks at draining this water away from the home and using it to irrigate vegetables, fruit trees and other beneficial plants.

The purpose of this study is to estimate the effects of greywater irrigation on the growth of plants commonly found in village home gardens. The field project consisted of constructing and managing household greywater irrigation systems …

Multiplexed Loop-Mediated Isothermal Amplification Of The 16s Rrna Gene For The Diagnosis Of Neonatal Sepsis In Resource-Limited Environments, Griffin T. Sonaty

Inquiry: The University of Arkansas Undergraduate Research Journal

Sepsis, or dysregulated inflammation caused by bacterial infection, places a disproportionately high burden on newborns in developing countries. This is due in part to a lack of diagnostic tools suitable for sustainable use in resource-limited nurseries. One potential vehicle for a new diagnostic assay is loop-mediated isothermal amplification (LAMP), a high-yield DNA amplification method. LAMP has previously been used to detect genes from single species of bacteria in blood serum samples to aid in sepsis diagnosis. LAMP could be adapted to detect a broad set of bacteria, while retaining a degree of specificity that allows clinicians to begin directed antimicrobial …

Programmable Dna Delivery To Cells Using Bioreducible Layer-By-Layer (Lbl) Polyelectrolyte Thin Films, Maria Muniz

Wayne State University Theses

Bioreducible, layer-by-layer (LbL) polyelectrolyte films show great promise for use in biomedical implant and gene-delivery applications. These nanometer-scale thin films can easily be coated onto a variety of implantable surfaces or devices. To achieve proof of concept, HEK-293, NIH/3T3, RAW, and MC3T3 cells were transfected using plasmid DNA with the green fluorescent protein reporter gene (GFP-DNA). In order to optimize transfection, a number of polyelectrolytes and biological components were systematically incorporated into the two similar basic LbL structures. Based on our previous degradation assays, it is shown that cellular interactions in vitro can break down the layers of the thin …

Binder Jet Additive Manufacturing Of Stainless Steel-Hydroxyapatite Bio-Composite, Don Suranga Dhanushka Uduwage

All Graduate Theses, Dissertations, and Other Capstone Projects

This study was conducted to create a bio-composite with a porous structure using the binder-jet printing additive manufacturing process. The samples were printed by changing the parameters such as layer thickness, roller speed, sintering time and sintering temperature of the X1-Lab binder jet additive manufacturing printer. The samples were printed 80% stainless steel 316 mixed with 20% Calcium Phosphate Tribasic by volume. Eight experiments were attempted to print according to the fractional factorial design of experiment. The effects of changing parameters on the mechanical properties of the new bio-composite was tested using ASTM E-09 compressive strength standards. The compression testing …

Controlling Pseudomonas Aeruginosa Persister Cells By Human Granulocyte Macrophage Colony-Stimulating Factor, Geetika Sanjay Choudhary

Dissertations - ALL

Bacteria are well known to cause chronic infections in humans by entering dormancy and by developing biofilms. These mechanisms allow bacteria to exhibit antibiotic tolerance and relapse to an active virulent state when the antibiotic treatments are discontinued. During bacterial invasions, the host immune cells secrete special signaling proteins, known as cytokines which orchestrate events leading to human immune response and elimination of bacterial pathogens. However, compared to the well documented activities

of cytokines in immune reaction, little is known about the direct effects of cytokines on bacterial cells.

In this study, we focused on granulocyte macrophage colony-stimulating factor (GM-CSF), …

Nasa Limited Inflight Lab Sensor, Gregory P. Howard, James C. Hanreck

Williams Honors College, Honors Research Projects

The National Aeronautics and Space Administration (NASA) is currently developing the capabilities needed to send humans to Mars in 2030 for a three year mission. Astronaut health must be monitored monthly during such a lengthy mission. The UA Enterprise Senior Design Team worked to design a reusable, novel blood panel cartridge system to monitor astronaut health and to minimize waste production. Most current cartridges are composed of polydimethylsiloxane (PDMS). PDMS microchannels were fabricated to conduct simple proof of concept experiments for the design of a novel cartridge. To determine an ideal blood cleaning solution, bovine blood will be injected into …

Optimizing Strategies For Population-Based Chlamydia Infection Screening Among Young Women: An Age-Structured System Dynamics Approach Infectious Disease Epidemiology, Yu Teng, Nan Kong, Wanzhu Tu

Weldon School of Biomedical Engineering Faculty Publications

Background

Chlamydia infection (CT) is one of the most commonly reported sexually transmitted diseases. It is often referred to as a “silent” disease with the majority of infected people having no symptoms. Without early detection, it can progress to serious reproductive and other health problems. Economical identification of asymptomatically infected is a key public health challenge. Increasing evidence suggests that CT infection risk varies over the range of adolescence. Hence, age-dependent screening strategies with more frequent testing for certain age groups of higher risk may be cost-saving in controlling the disease.

Methods

We study the optimization of age-dependent screening strategies …

Mass Media And The Contagion Of Fear: The Case Of Ebola In America, Sherry M J Towers, Shehzad Afzal, Gilbert Bernal, Nadya T. Bliss, Baltazar Espinoza, Jasmine Jackson, Julia Judson-Garcia, Maryam Khan, Michael Lin, Robert Mamada, Victor M. Moreno, Fereshteh Nazari, Kamaldeen Okumeye, Mary L. Ross, Claudia Rodriguez, Jan Medlock, David S. Ebert, Carlos Castillo-Chavez,

Department of Electrical and Computer Engineering Faculty Publications

Background: In the weeks following the first imported case of Ebola in the U. S. on September 29, 2014, coverage of the very limited outbreak dominated the news media, in a manner quite disproportionate to the actual threat to national public health; by the end of October, 2014, there were only four laboratory confirmed cases of Ebola in the entire nation. Public interest in these events was high, as reflected in the millions of Ebola-related Internet searches and tweets performed in the month following the first confirmed case. Use of trending Internet searches and tweets has been proposed in the …

Sheep Updates 2015 - Ravensthorpe, Bruce Mullan, Kate Pritchett, Kimbal Curtis, Chris Wilcox, Mike Hyder, Leigh Sonnerman, Lynne Bradshaw, Geoff Lindon, Katherine Davies, Joe Young, Stephen Lee, Ian Robertson, Lucy Anderton, Hayley Norman, Ed Barrett-Lenard, Jackie Jarvis, Ben Patrick

Sheep Updates

This session covers fourteen papers from different authors:

1. The Sheep Industry Business Innovation project, Bruce Mullan, Sheep Industry Development Director, Department of Agriculture and Food, Western Australia

2. Western Australian sheep stocktake, Kate Pritchett and Kimbal Curtis, Research Officers, Department of Agriculture and Food, Western Australia

3. Wool demand and supply - short term volatility, long term opportunities, Chris Wilcox, Principal of Poimena Analysis

4. Lifetime management for maternal ewes, Mike Hyder, Research Officer, Department of Agriculture and Food, Western Australia

5. National Livestock Identification System (NLIS) for sheep and goats - what is the NLIS database? Leigh Sonnermann, …

Sheep Updates 2015 - Merredin, Bruce Mullan, Kate Pritchett, Kimbal Curtis, Chris Wilcox, Lynne Bradshaw, Geoff Lindon, Katherine Davies, Joe Young, Stephen Lee, Dawson Bradford, Khama Kelman, Lucy Anderton, Jaq Pearson, Jackie Jarvis, Ben Patrick

Sheep Updates

This session covers fourteen papers from different authors:

1. The Sheep Industry Business Innovation project, Bruce Mullan, Sheep Industry Development Director, Department of Agriculture and Food, Western Australia

2. Western Australian sheep stocktake, Kate Pritchett and Kimbal Curtis, Research Officers, Department of Agriculture and Food, Western Australia

3. Wool demand and supply - short term volatility, long term opportunities, Chris Wilcox, Principal of Poimena Analysis

4. Myths, Facts and the role of animal welfare in farming, Lynne Bradshaw, president, RSPCA WA

5. Latest research and development on breech strike prevention, Geoff Lindon, Manager Productivity and Animal Welfare, AWI

6. …

Exploratory Study Of Seasonal Indoor Bioaerosols And The Associated Health Outcomes In Low-Income Communities In El Paso, Texas, 2014, Eric Martinez

Open Access Theses & Dissertations

Introduction: Structural degradation, moisture levels, and building failures can influence poor indoor air quality and create a good environment for bioaerosols. People spend much of their time indoors and can potentially be exposed to these bioaerosols. Several studies have correlated exposures to high concentrations of bioaerosols to various health problems, severe allergies, asthma, or other respiratory illness. Objectives: The objectives of this study are to describe bioaerosol concentrations, meteorological factors, and health outcomes during the summer and fall seasons; characterize bioaerosols (bacteria and fungi) collected in low-income communities; compare bioaerosol concentrations by season; compare meteorological factors to bioaerosol concentrations by …

Climate Change Implications For Health-Care Waste Incineration Trends During Emergency Situations, Emilia Mmbando Raila

Walden Dissertations and Doctoral Studies

Healthcare waste (HCW) incineration practices in the global South countries are among the major sources of black carbon (BC) emissions or smoke. This study analyzes HCW incineration trends during emergency situations and smoke from HCW incineration processes in Haiti. The study was prompted by the current arguments about the climate change and the growing health effects associated with BC emissions. The conceptual framework was based on both adverse health effects from BC emissions exposure and climate change potential of BC emissions. Therefore, the goal was to determine whether cardboard HCW sharps containers emit lower BC emissions to the atmosphere during …

Development Of A Three-Dimensional Bioprinter With Inline Light Activation For Bone Tissue Engineering, Colton Alexander Mcelheny

LSU Master's Theses

Bioprinting offers exciting possibilities for tissue engineering related to tissue and organ failure due to trauma, disease, or aging. This is of substantial societal value as the world populace mean age rises. Current needs for tissue and organ repair far exceed availability. A strategy being explored to counter this imbalance is the single step fabrication of cellular constructs. This paper explores various bioprinting techniques and suggests a custom design for a cost-effective, low-maintenance bioprinting platform for academic research. The platform functionality was validated via two-dimensional image transfer and simple three-dimensional geometries.

Development Of Satellite-Assisted Forecasting System For Oyster Norovirus Outbreaks, Jiao Wang

LSU Doctoral Dissertations

Norovirus outbreaks can cause the closure of oyster harvesting waters and acute gastroenteritis in humans associated with consumption of contaminated raw oysters. The overall goal of this study was to develop a satellite-assisted forecasting system for oyster norovirus outbreaks. The forecasting system is comprised of three components: (1) satellite algorithms for retrieval of environmental variables, including salinity, temperature, and gage height, (2) an Artificial Neural Network (ANN) based model, called NORF model, for predicting relative risk levels of oyster norovirus outbreaks, and (3) a mapping method for visualizing spatial distributions of norovirus outbreak risks in oyster harvest areas along Louisiana …

Electro-Disinfection Of Municipal Waste Water Using Direct Current, Julio A. Acosta Vega

LSU New Orleans Theses and Dissertations

Wastewater treatment has always been a problem to human settlers. Events such as the great stink of London during the summer of 1858 have pushed engineers into developing new technologies to deal with such wastes in effective and safe ways. Research projects like this aim to find ways of improving performance, economics, or environmental friendliness of treatment and disinfection methods.

This thesis deals with the effectiveness, mechanisms of action, by-products and side effects of using DC current to disinfect secondary effluent. It is proposed as an alternative to conventional methods, such as chlorination, which are not always environmentally friendly or …

Development And Characterization Of An Autologous Whole Cell Breast Cancer Vaccine, Samantha Leigh Kurtz

Graduate Theses and Dissertations

Approximately 40,000 women will die from breast cancer in the United States in 2014. About 90% of these deaths will be due to metastases, rather than the primary tumor and majority of metastases are due to the recurrence and progression of non-metastatic disease. Current adjuvant treatments, such as chemotherapy and radiation, have severe side effects and may result in overtreatment and drug resistance.

Since greater than 90% of patients are diagnosed between stages I-III and have minimal residual disease after treatment, there is an opportunity to treat patients with an autologous breast cancer vaccine. Autologous vaccines under development have a …

Low Molecular Weight Glucosamine/L-Lactide Copolymers As Potential Carriers For The Development Of A Sustained Rifampicin Release System: Mycobacterium Smegmatis As A Tuberculosis Model, Jorge Ragusa

Department of Chemical and Biomolecular Engineering: Dissertations, Theses, and Student Research

Tuberculosis, a highly contagious disease, ranks as the second leading cause of death from an infectious disease, and remains a major global health problem. In 2013, 9 million new cases were diagnosed and 1.5 million people died worldwide from tuberculosis. This dissertation aims at developing a new, ultrafine particle-based efficient antibiotic delivery system for the treatment of tuberculosis. The carrier material to make the rifampicin (RIF)-loaded particles is a low molecular weight star-shaped polymer produced from glucosamine (molecular core building unit) and L-lactide (GluN-LLA). Stable particles with a very high 50% drug loading capacity were made via electrohydrodynamic atomization. Prolonged …

A Portable Impedance Biosensing System Based On A Laptop With Labview For Rapid Detection Of Avian Influenza Virus, Yixiang Wang

Graduate Theses and Dissertations

Avian Influenza Virus (AIV) H5N1 is a highly pathogenic virus found not only in birds but also in human. Rapid and sensitive detection method is needed to help prevent the spread of AIV H5N1. In this study, a portable impedance biosensing system based on a laptop with LabVIEW software was developed for detection of AIV H5N1. First, a virtual instrument was programmed with LabVIEW software to form a platform for impedance measurement, data processing and control. The audio card of a laptop was used as a function generator while a data acquisition card was used with the signal channels for …

Flight Physician - October, 2014, Civil Aviation Medical Association

Browse all Civil Aviation Medical Association Newsletters

A twelve page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.

Likert-Type Fuzzy Uncertainty From A Traditional Decision Making Viewpoint: How Symmetry Helps Explain Human Decision Making (Including Seemingly Irrational Behavior), Joe Lorkowski, Vladik Kreinovich

Departmental Technical Reports (CS)

One of the main methods for eliciting the values of the membership function μ(x) is to use the Likert-type scales, i.e., to ask the user to mark his or her degree of certainty by an appropriate mark k on a scale from 0 to n and take μ(x) = k/n. In this paper, we show how to describe this process in terms of the traditional decision making, and we conclude that the resulting membership degrees incorporate both probability and utility information. It is therefore not surprising that fuzzy techniques often work better than probabilistic techniques (which only take into account …