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Teaching Learning Newsletter Vol 3 Issue 2, Sastra Deemed To Be University

TLC Newsletter

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Evaluation Of Amnion Membrane Made Vascular Graft In Rat Model And Porcine Model, Xiaolong Wang

Master's Theses (2009 -)

Heart bypass surgery has become a common therapeutic strategy to save heart attack patients from death. However, there are issues with the availability of graft resources for patients who cannot use autologous vessels due to their health conditions. To solve this problem, this study aims to develop a small-diameter vascular graft based on the human decellularized amniotic membrane (DAM) as an alternative to autologous vessels. The human amniotic membrane was harvested from the placenta, obtained from consenting and de-identified donors, and decellularized to remove cellular components while preserving its extracellular matrix. Small-diameter vascular grafts were fabricated using the DAM as …

On The Use Of Wireless Technologies For Wildlife Monitoring: Wireless Sensor Network Routing Protocols, Lilian Mutalemwa

Tanzania Journal of Engineering and Technology (TJET)

Traditional methods for wildlife monitoring are labor-intensive and time-consuming. Therefore, advanced technologies and remote monitoring methods are becoming increasingly popular. This paper presents a study on wireless technologies for wildlife monitoring. In the study, a review of the literature was done to identify the most commonly used wireless technologies. Various technologies were explored including unmanned aerial vehicles (UAVs), Internet of Things (IoT), wireless sensor networks (WSNs), artificial intelligence (AI), global positioning system (GPS), and very high frequency (VHF) radio. Then, a more detailed study was done on WSN technology. Investigations were done to observe the performance of routing protocols in …

Recent Advances In Electrochemical Impedance Spectroscopy-Based Pathogenic Bacteria Sensing, Tao Chen, Yuan-Hong Xu, Jing-Hong Li

Journal of Electrochemistry

Pathogenic bacteria have been throwing great threat on human health for thousands of years. Their real-time monitoring is in urgent need as it could effectively halt the spread of pathogenic bacteria and thus reducing the risk to human health. Up till now, diverse technologies such as electrochemistry, optics, piezoelectricity and calorimetry have been developed for bacteria sensing. Therein, electrochemical impedance spectroscopy (EIS)-based sensors show great potential in point-of-care bacterial analysis because of their low-cost, short read-out time, good reproducibility, and portable equipment construction. In this review, we will primarily summarize the typical applications of electrochemical impedance technology in bacteria sensing …

Acetate-Encapsulated Linolenic Acid Liposomes Reduce Sars-Cov-2 And Rsv Infection, Andrew R. Mcgill

USF Tampa Graduate Theses and Dissertations

Coronavirus disease-19 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), is an ongoing pandemic-endemic. In the United States, it remains the third leading cause of death in 2022. SARS-CoV-2, an RNA virus, has a genome prone to rapid mutation, generating variant species capable of resisting therapies and vaccination efforts. However, it has been estimated that more than 40% of SARS-CoV-2 infections may be asymptomatic, which calls into question any biological differences between the asymptomatic and afflicted groups. Additionally, Respiratory Syncytial Virus (RSV) is the most significant cause of bronchiolitis and asthma in neonates, with an increasing burden on the …

Predictive Modeling The Impact Of Engineered Products In Dynamic Sociotechnical Systems: An Agent-Based Approach, Christopher S. Mabey

Theses and Dissertations

The impact of engineered products is a topic of increasing concern in society. The impact of a product can fall into the categories of economic, environmental, or social impact; the last category is defined as the effect of a product on the daily lives of people. Design teams lack sufficient tools to help improve the impact of products and understand the impact of products at scale in society. This dissertation aims to provide insight and methods for improving the social, environmental, and economic impact of engineered products. The majority of the research focuses on the prediction of product impacts on …

The Impact Of Retrofitted Ventilation Approaches On Long-Range Airborne Infection Risk For Lecture Room Environments: Design Stage Methodology And Application, Adam O'Donovan

Publications

There is a continued need to improve the energy (and by extension carbon) performance of the existing building stock in Europe and globally. Recent experiences with the COVID-19 pandemic have demanded even more of the built environment disciplines when it comes to air quality and ventilation rates particularly in teaching environments which are seen as necessary developmental sectors for the learning of the population. As such it is important that these spaces are safe for students and staff where, until now, infectious disease risk assessments were not typical. In addition to this, there is a risk that envelope refurbishment (which …

Pcra-Icra Pre-Construction Risk Assessment/Infection Control Risk Assessment Course, Devin Alan Deiranieh

Construction Management

The Preconstruction Risk Assessment and Infection Control Risk Assessment (PCRA/ICRA) course is a collaboration between Cal Poly San Luis Obispo’s Construction Management Department, Cal Poly’s California Center for Construction Education, Green Advantage, LLC and Thomas Kommer, J.D. The goal is to create a certification course in which industry professionals become certified, signifying their knowledge and understanding of PCRA/ICRA practices associated with construction in the environment of patient care. The project began with the PCRA/ICRA manual authored by Stellar Performance, LLC. Working with Nicholas Schorno, the author developed the learning material for the course. The learning material consists of power point …

Development Of Non-Viral Nano-Carriers For Gene Delivery And Covid-19 Vaccines, Zhongyu Li

Dissertations

Gene therapy is one of the most promising medical fields with the potential to effectively advance the treatment of difficult diseases by producing therapeutic proteins or repairing defective gene sequences. However, gene therapy presents severe challenges in delivery including renal clearance, phagocytosis, enzymatic degradation, protein absorption, and cellular internalization barriers, which have been barriers for translation into the clinic. Naked nucleic acids, with their intrinsic negative charge, electrostatically repulse the anionic cell membrane, preventing cellular uptake. Also, they are considered foreign genetic material when introduced into the body and are rapidly cleared by the reticuloendothelial system or degraded by nucleases, …

Continuous Bioprocessing: Technology For Next-Generation Biopharmaceutical Manufacturing Development Of A Python-Coded Bench-Scale Raman-Based Continuous Bioprocess Platform, Christine Urrea

KGI Theses and Dissertations

Current industrial practices for producing biopharmaceuticals include fed-batch production with batch isolation and purification. Nonproductive hold-up steps and manual offline measurements are common in batch processing which increases processing time and contributes to a high cost of production. Current market trends and cost pressures in the biopharmaceutical industry are creating a push to innovate bioprocessing platforms. Continuous bioprocessing has been considered a solution to the current limitations of batch production of biopharmaceuticals. Continuous bioprocessing involves intensifying individual processing steps by eliminating hold-up steps through a continuous operation to increase productivity, which results in advantages such as lower capital and production …

The Development Of A Primer Payload With Microparticles For Uti Pathogen Identification Using Polythymidine- Modified Lamp Primers In Droplet Lamp, Jonas Otoo

KGI Theses and Dissertations

Nucleic acid amplification tests (NAATs) are among the diagnostic tests with the highest sensitivity and specificity. However, they are more complex to develop than other diagnostic tests such as biochemical tests and lateral flow immunoassay tests. Polymerase chain reaction (PCR) is the gold standard for NAATs. PCR requires thermal cycling to achieve clonal amplification of the target pathogen DNA for diagnosis. Thermal cycling poses a challenge in the development of PCR diagnostics for point-of-care (POC) settings. Loop-mediated isothermal amplification (LAMP) offers an isothermal method for NAATs diagnostics. The advancement of the microfluidics field significantly enhances the development of LAMP diagnostics …

Du Undergraduate Showcase: Research, Scholarship, And Creative Works, Caitlyn Aldersea, Justin Bravo, Sam Allen, Anna Block, Connor Block, Emma Buechler, Maria De Los Angeles Bustillos, Arianna Carlson, William Christensen, Olivia Kachulis, Noah Craver, Kate Dillon, Muskan Fatima, Angel Fernandes, Emma Finch, Colleen Cassidy, Amy Fishman, Andrea Francis, Stacia Fritz, Simran Gill, Emma Gries, Rylie Hansen, Shannon Powers, Jacqueline Martinez, Zachary Harker, Ashley Hasty, Mykaela Tanino-Springsteen, Kathleen Hopps, Adelaide Kerenick, Colin Kleckner, Ci Koehring, Elijah Kruger, Braden Krumholz, Maddie Leake, Lyneé Alves, Seraphina Loukas, Yatzari Lozano Vazquez, Haley Maki, Emily Martinez, Sierra Mckinney, Audrey Mitchell, Kipling Newman, Audrey Ng, Megan Lucyshyn, Andrew Nguyen, Stevie Ostman, Casandra Pearson, Alexandra Penney, Julia Gielczynski, Tyler Ball, Anna Rini, Christina Rorres, Simon Ruland, Helayna Schafer, Emma Sellers, Sarah Schuller, Claire Shaver, Kevin Summers, Isabella Shaw, Madison Sinar, Claudia Pena, Apshara Siwakoti, Carter Sorensen, Madi Sousa, Anna Sparling, Alexandra Revier, Brandon Thierry, Dylan Tyree, Maggie Williams, Lauren Wols

DU Undergraduate Research Journal Archive

DU Undergraduate Showcase: Research, Scholarship, and Creative Works

Implementation Of Methods For Cell Therapy Research And Assessment Of The Impact Of Cryopreservation, Samantha Lynes

Master's Theses

Cell therapy is the administration of living cells into a patient to prevent or treat a variety of diseases and illnesses. The cell therapy industry is rapidly expanding, and continued research is necessary for manufacturing safe and effective therapies. Although cell therapy manufacturing generally involves cryopreservation processes for storage, there are limited standards for cryopreservation processes and assays required to evaluate cell therapies post-thaw, and limited understanding exists about how a recovery period post-thaw could impact cell health. The overall goal of this thesis was to evaluate the effect of cryopreservation and potential subsequent recovery time on cell viability.

Because …

Detecting Pathobiomes Using Machine Learning, Valerie Jackson, Valerie Jackson

Industrial Engineering Undergraduate Honors Theses

Machine learning is a field with high growth potential due to the overall continuous progressions, developments, advancements, and improvements caused by the way it is used to help interpret and use large amounts of data [1]. One type of data that can be collected and analyzed by these machine learning models is data that is associated with DNA and information that the DNA gives. The research will be focusing specifically on using machine learning technology to detect pathobiomes indicative of salmonella pork. The pathobiome associated with salmonella is very similar to others, and this causes a problem for classification/detection with …

Autonomous Raman Hyperspectral Imaging And Analysis; Advances Towards Mapping Crystalline Character In Biologically Important Polymers, Sadeq H. Alkhalifa

ETD Archive

Poly-l-lactic acid has been of a great interest to the medical profession in recent years because of its biodegradability and biocompatibility. The biodegradation rate can be controlled by its crystallinity content. One method to modify its crystallinity content is by cold drawing. Raman spectroscopy is utilized to distinguish between the different crystalline content on the sample. However, a chemical imaging method is needed to characterize the polymer on the macro level. Chemical imaging using Raman spectroscopy is an important method of characterization that is non-invasive and non-destructive. The emphasis of my research has been to develop a method to characterize …

Kinetic Barriers For Leakage Reduction In Dna Autocatalytic Strand Displacement Networks, Drew Lysne

Boise State University Theses and Dissertations

Currently medical diagnostic methods suffer from the need for skilled labor, bulky, sophisticated and expensive equipment, ideal lab environments and ample time. A point-of-care biosensor can alleviate these problems and allow for more mobile disease detection. To meet this need, researchers have looked to DNA strand displacement networks to perform molecular level computation through a series of DNA strand displacement reactions in which disease associated biomarker inputs can trigger a cascaded signal to produce a readable output downstream in a matter of minutes. Such quick readable outputs require signal amplification. While amplification can be achieved through enzymatic activity, enzymes introduce …

Synthesis, Radiolabeling And Evaluation Of A Suite Of Tracers With 44Sc For Detecting Extracellular Dna, Zhiyao Li

McKelvey School of Engineering Graduate Student Theses & Dissertations

Neutrophil extracellular traps involve the rapid translocation of DNA to the outside of the cell under certain stimuli. This structure forms a fibrous network that is able to limit the spread of pathogens and to kill microorganisms. It has also been shown to be present in various pathological processes such as inflammation, autoimmune diseases, and cancer metastasis. Currently, the formation process of NETs in vivo is being extensively studied. However noninvasive detection and quantitation has yet to be achieved. A class of PET tracers are described here that consists of a DNA dye as the backbone that is labeled with …

Editorial: Disease Biomarker Analysis Based On Optical Biosensing, Tianshu Chen, Fanben Meng, Binwu Ying, Xiaoli Zhu

Department of Mechanical and Materials Engineering: Faculty Publications

Disease biomarker analysis has become a crucial tool for diagnosing and evaluating disease prognosis, especially with the increasing understanding of diseases at the molecular level. Abnormalities in various biomarkers can indicate diseased states, and can be used to rapidly and specifically detect and quantify diseases using optical biosensing techniques (Gao et al., 2023). Optical biosensing techniques have several advantages over traditional methods including higher sensitivity, specificity, and faster analysis times (Plikusiene and Ramanaviciene, 2023). It also allows for non-invasive sample collection. With advancements in optical biosensing technology, many medical conditions including cancers, infectious diseases, and autoimmune disorders can be accurately …

Editorial: Disease Biomarker Analysis Based On Optical Biosensing, Tianshu Chen, Fanben Meng, Binwu Ying, Xiaoli Zhu

Department of Mechanical and Materials Engineering: Faculty Publications

Disease biomarker analysis has become a crucial tool for diagnosing and evaluating disease prognosis, especially with the increasing understanding of diseases at the molecular level. Abnormalities in various biomarkers can indicate diseased states, and can be used to rapidly and specifically detect and quantify diseases using optical biosensing techniques (Gao et al., 2023). Optical biosensing techniques have several advantages over traditional methods including higher sensitivity, specificity, and faster analysis times (Plikusiene and Ramanaviciene, 2023). It also allows for non-invasive sample collection. With advancements in optical biosensing technology, many medical conditions including cancers, infectious diseases, and autoimmune disorders can be accurately …

Development Of Graphene Oxide/Carbon Nanofiber Hybrid Structure, Greta Wilkins

Liberty University Research Week

Undergraduate

Applied

Covid-19: Visualized Qualitative Aviation Research Themes, Chien-Tsung Lu, Huabo Sun

Journal of Aviation Technology and Engineering

The purpose of this study is to review pandemic-related publications that help the aviation industry cope with pandemic outbreaks like that of COVID-19. Published documents were searched and downloaded from academic libraries including Web of Science for a qualitative analysis. After the triangulation of publications for decisionmakers, and researchers, all important research clusters were visually generated based on the VOSviewer process. Some research clusters were further discussed for a thorough understanding of existing research perspectives. The result discovered that wearing a face mask and vaccination have been the two most effective means to counteract pandemic outbreaks. Additional findings were extracted …

"Challenging The Known." 16th Annual Research Week: Event Proceedings, University Of The Incarnate Word

Excellence Summit (Research Week) Archived Proceedings

Presentations of completed and ongoing research activity conducted by graduate students, undergraduate students, and faculty at University of the Incarnate Word. Includes poster, podium, visual arts, interactive demo, and creative and performing arts presentations. Coordinated and presented by the Office of Research and Graduate Studies.

Engineered Production Of Bioactive Polyphenolic O-Glycosides, Jie Ren, Caleb Don Barton, Jixun Zhan

Biological Engineering Faculty Publications

Polyphenolic compounds (such as quercetin and resveratrol) possess potential medicinal values due to their various bioactivities, but poor water solubility hinders their health benefits to humankind. Glycosylation is a well-known post-modification method to biosynthesize natural product glycosides with improved hydrophilicity. Glycosylation has profound effects on decreasing toxicity, increasing bioavailability and stability, together with changing bioactivity of polyphenolic compounds. Therefore, polyphenolic glycosides can be used as food additives, therapeutics, and nutraceuticals. Engineered biosynthesis provides an environmentally friendly and cost-effective approach to generate polyphenolic glycosides through the use of various glycosyltransferases (GTs) and sugar biosynthetic enzymes. GTs transfer the sugar moieties from …

Characterization Of Physical And Biochemical Traits In Wheat And Corn Plants Using High Throughput Image Analysis, Kantilata Thapa

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Plant phenotyping has been recognized as a rapidly growing field of research due to the labor-intensive, destructive, and time-consuming nature of traditional phenotyping methods. These phenotyping bottlenecks can be addressed by advancements in image-based phenotyping like RGB and hyperspectral imaging for the assessment of plant traits important for breeding purposes. This study aims (1) to characterize the physical and biochemical traits of wheat and corn plants using RGB and hyperspectral imaging in the greenhouse, and (2) to estimate leaf nitrogen (N), phosphorus (P), and potassium (K) content using hyperspectral imaging and an analytical spectral device (ASD spectrometer) and compare the …

Utilizing The System Engineering Trade Study Analysis Method To Analyze Patient Aeromedical Evacuation, Sara Shaghaghi, Jeremy M. Slagley, Michael E. Miller, Gaiven Varshney

Faculty Publications

The US Air Force has gone through many aeromedical patient isolation transport system designs. The first designs were developed in response to the Ebola outbreak in 2014 and, more recently, the COVID-19 pandemic. The trade study analysis part of the system engineering design method was used to analyze the historic and current aeromedical patient contamination control transport systems. A trade study is a process that evaluates alternatives based upon various “-ilities”, such as reconfigurability, flexibility, durability, cost, and more, and performs a systematic analysis to aid designers in producing a ‘good’ design alternative given the large set of possible solutions. …

Effect Of Storage Condition On Penetration Threshold Of Porcine Skin Tissue, Jared Michael Koser

Master's Theses (2009 -)

Buried blast explosions create small projectiles which can become lodged in the tissue of personnel as far away as hundreds of meters. Without appropriate treatment, these lodged projectiles can become a source of infection and prolonged injury to soldiers in modern combat. Human cadavers can be used as surrogates for living humans for ballistic penetration testing, but human cadavers are frozen during transport and storage. The process of freezing and thawing the tissue before testing may change the biomechanical properties of the tissue. The goal of the current study was to investigate the effect of tissue storage on penetration threshold …

Calculation Of Optimal Vocs Emission Reduction Based On Improved Seirs Model In Cloud Environment, Guangqiu Huang, Xixuan Zhao, Qiuqin Lu

Journal of System Simulation

Abstract: Volatile organic compounds (VOCs) emissions in different regions are correlated and influenced. In order to minimize the impact of VOCs on the atmospheric environment and achieve synergistic governance of VOCs regions, an optimal emission reduction model is established with the maximum VOCs emission reduction as the primary goal. An improved SEIRS infectious disease dynamics optimization algorithm considering environmental pollution(SEIRS-CE) is proposed and the model is solved in cloud environment. Taking Xi'an city as an example, the SEIRS-CE algorithm is used in Ali cloud server to calculate the emission reduction of VOCs associated with 13 meteorological monitoring stations in Xi …

Application Of Convergent Science And Technology Toward Ocular Disease Treatment, Ayca Bal-Ozturk, Ece Ozcan-Bulbul, Hazal Ezgi Gultekin, Berivan Cecen, Ebru Demir, Atefeh Zarepout, Sibel Cetinel, Ali Zarrabi

Henry M. Rowan College of Engineering Departmental Research

Eyes are one of the main critical organs of the body that provide our brain with the most information about the surrounding environment. Disturbance in the activity of this informational organ, resulting from different ocular diseases, could affect the quality of life, so finding appropriate methods for treating ocular disease has attracted lots of attention. This is especially due to the ineffectiveness of the conventional therapeutic method to deliver drugs into the interior parts of the eye, and the also presence of barriers such as tear film, blood-ocular, and blood-retina barriers. Recently, some novel techniques, such as different types of …

Ferric Chloride-Induced Arterial Thrombosis And Sample Collection For 3d Electron Microscopy Analysis, Smita Joshi, Alexis N. Smith, Kanakanagavalli Shravani Prakhya, Hammodah Rawhi Hammodah Alfar, Joshua Lykins, Ming Zhang, Irina D. Pokrovskaya, Maria A. Aronova, Richard D. Leapman, Brian Storrie, Sidney W. Whiteheart

Saha Cardiovascular Research Center Faculty Publications

Cardiovascular diseases are a leading cause of mortality and morbidity worldwide. Aberrant thrombosis is a common feature of systemic conditions like diabetes and obesity, and chronic inflammatory diseases like atherosclerosis, cancer, and autoimmune diseases. Upon vascular injury, usually the coagulation system, platelets, and endothelium act in an orchestrated manner to prevent bleeding by forming a clot at the site of the injury. Abnormalities in this process lead to either excessive bleeding or uncontrolled thrombosis/insufficient antithrombotic activity, which translates into vessel occlusion and its sequelae. The FeCl3-induced carotid injury model is a valuable tool in probing how thrombosis initiates and progresses …

3d Printed Composite Structures For Bone Repair And Drug Delivery Application, Innocent J. Macha

Tanzania Journal of Engineering and Technology (TJET)

Due to the increase in traffic accidents, industrial contingencies, and natural disasters, there is a high demand for bone regeneration biomaterials. Although bone can regenerate and self-repair, it is difficult to do so when the defect area exceeds the critical repair area due to trauma, tumour resection, or congenital diseases. The traditional methods for bone repair are autograft, allograft, and xenograft. However, these methods have flaws and limitations, such as complications in the donor bone area, a limited number of donors, rejection, and infectious diseases. However, in recent years, the use of additive manufacturing technologies in bone tissue engineering has …