Digital Commons Network^™

Use Of Cosine Modulated Filter Bank To Quantify Human Muscle Fatigue Using Electromyography Signals Obtained During Isometric Voluntary Contractions, Liza Stephanie Rodriguez

Open Access Theses & Dissertations

As technology continues to advance, there continues to be an interest in applying engineering theories to solve medical problems. Technology has allowed researchers to investigate the properties and characteristics of the human body in hopes of emulating their complexities. The rising interest in the study of biopotentials for use in prosthetic limbs, exoskeletons and machine interfacing has led to a necessity to validate that the understanding of these signals is accurate. The study of biopotentials generated by muscles via a method known as electromyography (EMG) has improved the understanding of effects of rehabilitative treatments, assisted in diagnosing diseases, control of …

Women In Science 2014, Clark Science Center's Summer Research Fellows Program

SURF Abstracts (Women in Science)

Women in Science 2014 summarizes research done by Smith College’s Summer Research Fellowship (SURF) Program participants. Ever since its 1967 start, SURF has been a cornerstone of Smith’s science education. In 2014, 150 students participated in SURF (141 hosted on campus and nearby eld sites), supervised by 61 faculty mentor-advisors drawn from the Clark Science Center and connected to its eighteen science, mathematics, and engineering departments and programs and associated centers and units. At summer’s end, SURF participants were asked to summarize their research experiences for this publication.

Physical Stability Of Poly (Lactic-Co-Glycolic Acid) And Plga/Chitosan Nanoparticles And Chemical Stability Of Entrapped Alpha-Tocopherol And Lutein, Meocha Whaley

LSU Master's Theses

The published benefits of polymeric nanoparticles as a system for antioxidant delivery have encompassed topics of improved oral delivery, bioavailability, and modified release to name a few. Generally accepted as safe polymers Poly(lactic-coglycolic acid) and the mucoadhesive chitosan were selected to entrap alpha-tocopherol and lutein. This study proposed to assess the physical stability of PLGA and Chi/PLGA nanoparticles with entrapped bioactives in varying biological suspension medias ( water, pbs, hbss and cell media). Also, to assess the chemical stability of the entrapped antioxidants lutein and alpha-tocopherol within the same media as deemed relevant for in-vitro and and in-vivo studies. Of …

Vascular Nanomedicine: Site Specific Delivery Of Elastin Stabilizing Therapeutics To Damaged Arteries, Aditi Sinha

All Dissertations

Elastin, a structural protein in the extra-cellular matrix, plays a critical role in the normal functioning of blood vessels. Apart from performing its primary function of providing resilience to arteries, it also plays major role in regulating cell-cell and cell-matrix interactions, response to injury, and morphogenesis. Medial arterial calcification (MAC) and abdominal aortic aneurysm (AAA) are two diseases where the structural and functional integrity of elastin is severely compromised. Although the clinical presentation of MAC and AAA differ, they have one common underlying causative mechanism--pathological degradation of elastin. Hence prevention of elastin degradation in the early stages of MAC and …

Characterization Of Two-Dimensional Oculomotor Control During Goal-Directed Eye Movements In Humans, Vincent Dang

Master's Theses (2009 -)

Oculomotor control is a subset of sensorimotor control that allows humans to make extremely accurate eye movements for ADL. Impairments to oculomotor control can increase the impact of sensorimotor control deficits, especially in neurodegenerative diseases such as MS. Here, a two-dimensional computational control system of saccades and smooth-pursuit eye movements was compiled from literature to systematically characterize oculomotor control in eight visually-healthy humans as a precursor to studying the relationship between oculomotor and sensorimotor control in patient populations. Subjects visually tracked a single dot on a 41 x 30.5 cm monitor in a dark room while eye positions were recorded …

Multimodal Wearable Sensors For Human-Machine Interfaces, Mark Nolan

Doctoral

Certain areas of the body, such as the hands, eyes and organs of speech production, provide high-bandwidth information channels from the conscious mind to the outside world. The objective of this research was to develop an innovative wearable sensor device that records signals from these areas more conveniently than has previously been possible, so that they can be harnessed for communication. A novel bioelectrical and biomechanical sensing device, the wearable endogenous biosignal sensor (WEBS), was developed and tested in various communication and clinical measurement applications.

One ground-breaking feature of the WEBS system is that it digitises biopotentials almost …

Spatiotemporal Smoothing As A Basis For Facial Tissue Tracking In Thermal Imaging, Yan Zhou, Panagiotis Tsiamyrtzis, Peggy Lindner, Ilya Timofeyev, Ioannis Pavlidis

Engineering Management and Systems Engineering Faculty Research & Creative Works

Accurate tracking of facial tissue in thermal infrared imaging is challenging because it is affected not only by positional but also physiological (functional) changes. This paper presents a particle filter tracker driven by a probabilistic template function with both spatial and temporal smoothing components, which is capable of adapting to abrupt positional and physiological changes. The method was tested on tracking facial regions of subjects under varying physiological and environmental conditions in 25 thermal clips. It demonstrated robustness and accuracy, outperforming other strategies. This new method promises improved performance in a number of biomedical applications that involve physiological measurements on …

A Computed Tomography-Based Model Of The Infant Hip Anatomy For Dynamic Finite Element Analysis Of Hip Dysplasia Biomechanics, Kyle Snethen

HIM 1990-2015

Newborns diagnosed with hip dysplasia face severe consequences when treatments fail. The Pavlik harness presents the most common worldwide treatment for correcting this medical hip abnormality in newborns, but becomes increasingly ineffective as subluxation increases. A dynamic finite element analysis on the hip joint would yield results that could provide insight to physicians as to how the Pavlik harness could be optimized to increase its success rate and develop patient-specific treatment plans. The study completes the first step in such an analysis by generating a three-dimensional model of an infant hip joint directly derived from computed tomography imaging in order …

Incorporating Industry Needs Into The Development Of An Undergraduate Degree In Commercial Space Operations, Yash Bipinchandra Mehta

Doctoral Dissertations and Master's Theses

The rapid expansion of the commercial space industry, not unlike the aviation industry in the early 20^th century, has left the industry facing unique challenges. As companies continue to expand, the need for a well-trained workforce becomes critical. The needed workforce must be specifically educated to enter the commercial space industry at graduation. To have a successful industry, a workforce must be trained in skills that meet the industry's needs. In that regard, this study consisted of a survey of leaders in the commercial space industry to identify the different skill-sets sought by the industry. The results of the …

Discrimination Between Child And Adult Forms Using Radar Frequency Signature Analysis, Stephanie R. Keith

Theses and Dissertations

In this thesis we develop a method to discriminate between adult and child radar signatures. In particular, we examine radar data measured from behind a wall, which introduces radar signal attenuation and multipath effects. To investigate the child/adult discrimination problem in a through-wall, multipath scenario, a previously developed free-space human scattering model was expanded to incorporate multiple paths, and the effects of transmission through, and reflections from, walls and ground. The ground was modeled as a perfectly reflecting surface, while the walls were modeled as homogeneous concrete slabs. Twenty-five reflection paths were identified, involving the direct paths, as well as …

Optimization Of Spray Droplet Size For Drug Delivery To The Deep Lung, Renee Worden

Electronic Theses and Dissertations

The lower respiratory regions of the lung boast over 900 million alveoli with a combined 85 m2 of surface area of near direct access to the bloodstream. Within the last century the immense potential of the deep lung as a site for the delivery of drugs has begun to be exploited and today pulmonary delivery of aerosolized therapeutic is commonplace. However, the high inter- and intra-patient variability in dosing is almost completely ignored. Currently, no steps are being taken to mitigate the sources of variability beyond injection into the upper airways. This study seeks to prove that a careful selection …

Simulation-Based Cognitive Workload Modeling And Evaluation Of Adaptive Automation Invoking And Revoking Strategies, Christina Rusnock

Electronic Theses and Dissertations

In human-computer systems, such as supervisory control systems, large volumes of incoming and complex information can degrade overall system performance. Strategically integrating automation to offload tasks from the operator has been shown to increase not only human performance but also operator efficiency and safety. However, increased automation allows for increased task complexity, which can lead to high cognitive workload and degradation of situational awareness. Adaptive automation is one potential solution to resolve these issues, while maintaining the benefits of traditional automation. Adaptive automation occurs dynamically, with the quantity of automated tasks changing in real-time to meet performance or workload goals. …

Imaging Iron Content In Patients With Multiple Sclerosis Using Magnetic Resonance Imaging, Charbel Abdo Habib

Wayne State University Dissertations

The importance of iron in maintaining normal physiological processes in the human body has been well emphasized in the literature. However, "when iron behaves badly", its abnormal presence might lead to a spectrum of pathologies depending on what function has been altered. In the brain, for instance, abnormal iron content is thought to be associated with neurodegenerative diseases. In this dissertation, we study iron involvement in one of the most debilitating neurological diseases, multiple sclerosis (MS), using in vivo magnetic resonance imaging. We first test the sensitivity and specificity of the MR method used, known as susceptibility weighted imaging (SWI) …

Development Of A Multilayered Association Polymer System For Sequential Drug Delivery, Sharath Kumar Chinnakavanam Sundararaj

Theses and Dissertations--Biomedical Engineering

As all the physiological processes in our body are controlled by multiple biomolecules, comprehensive treatment of certain disease conditions may be more effectively achieved by administration of more than one type of drug. Thus, the primary objective of this research was to develop a multilayered, polymer-based system for sequential delivery of multiple drugs. This particular device was designed aimed at the treatment of periodontitis, a highly prevalent oral inflammatory disease that affects 90% of the world population. This condition is caused by bacterial biofilm on the teeth, resulting in a chronic inflammatory response that leads to loss of alveolar bone …

Investigation Of Multiscale Fluid Structure Interaction Modeling Of Flow In Arterial Systems, Sebastian Sotelo

Electronic Theses and Dissertations

The study of hemodynamic patterns in large blood vessels, such as the ascending aortic artery, brachiocephalic trunk, right carotid artery and right subclavian artery presents the challenging complexity of vessel wall compliance induced by the high levels of shear stress gradients and blood flow pulsatility. Accurate prediction of hemodynamics in such conditions requires a complete Fluid Structure Interaction (FSI) analysis that couples the fluid flow behavior throughout the cardiac cycle with the structural response of the vessel walls. This research focuses on the computational study of a Multiscale Fluid-Structure Interaction on the arterial wall by coupling Finite Volumes Method (FVM) …

Design Of A Running Robot And The Effects Of Foot Placement In The Transverse Plane, Timothy James Sullivan

Open Access Theses

The purpose of this thesis is to make advances in the design of humanoid bipedal running robots. We focus on achieving dynamic running locomotion because it is one metric by which we can measure how far robotic technologies have advanced, in relation to existing benchmarks set by humans and other animals. Designing a running human-inspired robot is challenging because human bodies are exceptionally complex mechanisms to mimic. There are only a few humanoid robots designed specifically for running and the existing robots are either constrained to a plane, do not yet exhibit human-like motion, or are unstable.

One aspect of …

Application Of Computational Fluid Dynamics As A Simulation-Based Design Guide In A Microfluidic 3d Living Cell Array (3d Lca) Device, A.H. Rezwanuddin Ahmed

Dissertations and Theses

The use of computational fluid dynamics (CFD) as a tool in the aerodynamics and oil industry provides a reinforcement to efficiency in the design of aircrafts or for understanding the flow through pipes. A similar approach can be taken towards microfluidics, where traditionally devices have been designed based on experience or physiological replication, and a CFD simulation is shown post-manufacture to show the flow and diffusion patterns present. In this study, a reverse approach is suggested, by designing the device first in CFD and perform simulations on variations of alterable parameters to get insight on how the changing parameters affect …

Strategic Optimization Techniques For Frtu Deployment And Chip Physical Design, Chen Liao

Dissertations, Master's Theses and Master's Reports - Open

Combinatorial optimization is a complex engineering subject. Although formulation often depends on the nature of problems that differs from their setup, design, constraints, and implications, establishing a unifying framework is essential. This dissertation investigates the unique features of three important optimization problems that can span from small-scale design automation to large-scale power system planning: (1) Feeder remote terminal unit (FRTU) planning strategy by considering the cybersecurity of secondary distribution network in electrical distribution grid, (2) physical-level synthesis for microfluidic lab-on-a-chip, and (3) discrete gate sizing in very-large-scale integration (VLSI) circuit.

First, an optimization technique by cross entropy is proposed to …

Adsorption Of Arsenic, Chromium, And Uranium From Saline Water On Clinoptilolite And The Treatment Of The Spent Regenerant By Duffusion Dialysis, Mutiu Olaitan Tanimola

Open Access Theses & Dissertations

Among various water purification and recycling technologies, adsorption is a fast, inexpensive and universal method. The development of low-cost adsorbents has led to the rapid growth of research interests in this field. The objective of this present study is the optimization of process parameters in adsorption of arsenic, chromium and uranium ions. The adsorption behavior of natural zeolite (clinoptilolite) has been studied in order to determine its applicability in treating water containing arsenic, chromium and uranium. The multiple adsorption of arsenic As (V), trivalent chromium Cr (III)] and uranium (VI) on natural zeolite (clinoptilolite) in single component and multiple component …

Classification Models In Clinical Decision Making, Eleazar Gil-Herrera

USF Tampa Graduate Theses and Dissertations

In this dissertation, we present a collection of manuscripts describing the development of prognostic models designed to assist clinical decision making. This work is motivated by limitations of commonly used techniques to produce accessible prognostic models with easily interpretable and clinically credible results. Such limitations hinder prognostic model widespread utilization in medical practice.

Our methodology is based on Rough Set Theory (RST) as a mathematical tool for clinical data anal- ysis. We focus on developing rule-based prognostic models for end-of life care decision making in an effort to improve the hospice referral process. The development of the prognostic models is …

Biomechanics Of Patient Handling Slings Associated With Spinal Cord Injuries, Julie Kahn

USF Tampa Graduate Theses and Dissertations

Pressure ulcers and related skin integrity threats are a significant problem in current transfer/transport systems used for spinal cord injury patients. To understand this problem twenty-three different slings with varying type, material, and features were analyzed in hopes to identify at-risk areas for skin integrity threats such as pressure ulcers. Population samples included non-disabled (otherwise referred to as "healthy") volunteers as well as SCI patients from the James A. Haley Veterans Hospital. High resolution pressure interface mapping was utilized to directly measure the interface pressures between the patient and sling interface. Overall results provide relevant feedback on the systems used …

Building Envelope Wind Pressure Manipulation For Application In Streamlined High-Rise Buildings, Sivaramprasad Sivakumar

Mechanical and Aerospace Engineering - Dissertations

This research investigates methods of manipulating building envelope wind pressure distribution for application in the natural ventilation of high-rise buildings. CFD simulations are employed to predict the wind pressure distribution around the building envelope. First, a 2-D CFD study is conducted to explore various techniques of manipulating the building envelope wind pressure distribution. This study indicates that the use of externally mounted flow-resistance devices is an effective method of manipulating the wind pressure distribution. It is demonstrated that this technique is well suited for application to buildings of streamlined cross-section (e.g. elliptical planform). Next, a 3-D CFD study is conducted …

The Effects Of Energy Beverages In Counteracting The Symptoms Of Mild Hypoxia At Legal General Aviation Altitudes, Daniel Mark Bull

Doctoral Dissertations and Master's Theses

The purpose of this thesis was to conduct preliminary research, in the form of a pilot study, concerning the natural effects of hypoxia compared to the effects of hypoxia experienced after the consumption of an energy beverage. The study evaluated the effects of hypoxia on FAA certificated pilots at a simulated legal general aviation altitude, utilizing the normobaric High Altitude Lab (HAL) located at Embry Riddle Aeronautical University, Daytona Beach, Florida. The researcher tested 11 subjects, who completed three simulated flight tasks within the HAL using the Frasca International Mentor Advanced Aviation Training Device (AATD). The flight tasks were …

Phoneme Weighting And Energy-Based Weighting For Speaker Recognition, Eric Fang

All Dissertations

This dissertation focuses on determining specific vowel phonemes which work best for speaker identification and speaker verification, and also developing new algorithms to improve speaker identification accuracy. Results from the first part of our research indicate that the vowels /i/, /E/ and /u/ were the ones having the highest recognition scores for both the Gaussian mixture model (GMM) and vector quantization (VQ) methods (at most one classification error). For VQ, /i/, /I/, /e/, /E/ and /@/ had no classification errors. Persons speaking /E/, /o/ and /u/ have been verified well by both GMM and VQ methods in our experiments. For …

Effects Of Oxygen Deprivation On Pilot Performance And Cognitive Processing Skills: A Pilot Study, David Francis Shideler

Doctoral Dissertations and Master's Theses

According to Federal Aviation Administration (FAA) regulations, pilots flying above 14,000 ft. are required to use supplemental oxygen. The purpose of this study was to examine how oxygen deprivation below 14,000 ft. affects pilot performance using the Frasca Mentor Advanced Aviation Training Device (AATD), and cognitive processing skills using the Automated Neuropsychological Assessment Metrics (ANAM(TM)) cognitive test. The study was conducted in a Normobaric High Altitude Laboratory at simulated altitudes of 5,000 ft. and 14,000 ft. In this pilot study, only five participants were tested; non-significant results of the analysis were anticipated; however, as oxygen levels decreased and time of …

Development And Validation Methodology Of The Nuss Procedure Surgical Planner, Krzysztof J. Rechowicz

Computational Modeling & Simulation Engineering Theses & Dissertations

Pectus excavatum (PE) is a congenital chest wall deformity which is characterized, in most cases, by a deep depression of the sternum. A minimally invasive technique for the repair of PE (MIRPE), often referred to as the Nuss procedure, has been proven to be more advantageous than many other PE treatment techniques. The Nuss procedure consists of placement of a metal bar(s) underneath the sternum, thereby forcibly changing the geometry of the ribcage. Because of the prevalence of PE and the popularity of the Nuss procedure, the demand to perform this surgery is greater than ever. Therefore, a Nuss procedure …

Preparation And Characterization Of Electrospun Poly(D, L-Lactide-Co-Glycolide) Scaffolds For Vascular Tissue Engineering And The Advancement Of An In Vitro Blood Brain Barrier Model, Deven Chandrakant Patel

Master's Theses

Developing an in vitro Blood Brain Barrier model that will replicate the physiological, anatomical, and functional characteristics of the native BBB has gained significant attention. Such a model would enable prediction of the penetration of CNS targeting drug candidates across the BBB, allow pre-screening and optimization strategies to be developed for new drugs and gene delivery formulations, and permit research groups to further understand how a dysfunctional BBB is involved in the pathogenesis of several neurological diseases.

The Tissue Engineering laboratory at the California Polytechnic State University, San Luis Obispo is currently in the process of developing a dynamic in …

Flying Qualities Built-In-Test For Unmanned Aerial Systems, Alton Pak-Hin Chiu

Master's Theses

This paper presents a flying qualities built-in-test for UAS application with the scope limited to the longitudinal axis. A doublet input waveform excites the AV and both α and q are used by EUDKF to estimate the A and B matrices which are short period approximations of the system. ζ, ω, GM, PM, observability, and controllability are calculated to determine flying qualities with the results displayed to the AVO in a color-coded, easy to interpret display.

While SID algorithms have been flying in vehicles with adaptive control schemes, vehicles with other schemes (such as classical feedback) lack this built-in self …

Adding Cerebral Autoregulation To A Lumped Parameter Model Of Blood Flow, Russell Gentile

HIM 1990-2015

A mathematical model of blood flow in infants with hypoplastic left heart syndrome (HLHS) was improved by adding cerebral autoregulation. This is the process by which blood vessels constrict or dilate to keep blood flow steady in certain organs during pressure changes. The original lumped parameter model transformed the fluid flow into an electrical circuit. Its behavior is described using a system of thirty-three coupled differential equations that are solved numerically using a fourth-order Runge-Kutta method implemented in MATLAB. A literature review that includes a discussion of autoregulation mechanisms and approaches to modeling them is followed by a description of …

Assessing Color Discrimination, Joshua R. Maxwell

Doctoral Dissertations and Master's Theses

The purpose of this study was to evaluate human color vision discriminability within individuals that have color normal vision and those that have color deficient vision. Combinations of 15 colors were used from a list of colors recommended for computer displays in Air Traffic Control settings, a population with some mildly color vision deficient individuals. After a match to sample test was designed to assess the limits of human color vision discrimination based on color saturation and hue, standard color diagnostic tests were used to categorize college students as having normal or deficient color vision. The results argue that color …