Digital Commons Network^™

An Investigation Of Data Granularity In Rag Pipelines For Personalized Medicine, Paritosh Pandey

Master's Theses

Generative AI, exemplified by large language models like the OpenAI GPT and Meta LLaMA families, can produce diverse content in response to prompts. This capability offers a promising solution to challenges in precision medicine, which seeks to tailor treatments to individual clinical profiles but often struggles with data collection, cost, and privacy concerns. By generating realistic, privacy-preserving patient data, generative AI has the potential to transform patient-centric healthcare. With such motivation, this research develops a comprehensive Generative AI pipeline emphasizing data granularity for accurate prediction of personalized treatments. The pipeline features a central Large Language Model interacting with a Machine …

Investigation Of Low-Pressure Mercury Lamp System Configurations And Xenon Excimer Lamp System Development As Vacuum Ultraviolet Sources For Optimal Photolytic Degradation Of Poly-/Perfluoroalkyl Substances, Eman Zuhair Alhamdan

All Dissertations

PFAS are persistent synthetic chemicals, with unique properties that enable them to easily enter and accumulate in water sources. Their public health impacts have raised concern and highlighted the need for effective treatment. Numerous techniques for PFAS removal from water have been studied, few have proven the ability of breaking down PFAS rather than separating and concentrating it. Many of these methods are chain-length dependent, showing slower degradation rate of short-chain PFAS and requiring substantial amounts of energy, and chemical agents that may produce byproducts.

Among available PFAS destruction methods, direct photolysis by high-energy UV with wavelength below 200 nm …

Learning Global Context For Sparse Activity Recognition In Lengthy Recordings With Limited Dataset Size, Zeyu Tang

All Dissertations

This dissertation describes methods to analyze lengthy recordings of data in order to detect sparsely occurring activities. The narrative below describes the progression of research that led to the development of these methods and their generalization into a unified framework. My research started with designing models for dietary monitoring, including detecting meals from day-long recordings and detecting intake gestures from meal-length recordings. Both tasks share some common characteristics: (a) the target event takes only a small portion of data recordings, and (b) there is global context within full-length data recordings that can help a model make better decisions. After finishing …

Experimental And Computational Investigation Of The Effects Of Neck Musculature During Head Impacts In American Football, Anthony P. Marino

All Dissertations

Anthropometric test devices (ATDs) are human surrogate models used to represent the human body response in the context of compliance and safety testing. These devices are used in multiple industries, including automotive and aerospace, and have recently been incorporated into impact testing for the evaluation of helmet performance in American football. The Hybrid III 50^th percentile male ATD head and neck assembly is the most commonly used surrogate for these tests, although it was developed for automotive frontal crash scenarios that induce an inertial force on the body, leading to head and neck motion primarily in the sagittal plane. …

Versatile Exoskeleton Control Paradigms For Agile Human Locomotion: Task-Agnostic And Stability-Augmented Assistance, Miao Yu

All Dissertations

Lower-limb exoskeletons have shown great potential for assisting human locomotion, but designing controllers that provide assistance across diverse locomotor tasks and under external perturbations remains a major challenge. Many existing controllers for steady-state walking rely on pre-defined reference trajectories, which constrain voluntary human motion and limit adaptability across tasks. Moreover, they usually assume stable walking, while their performance under unstable conditions remains largely unexplored. In addition, existing gait stability augmentation controllers are often reactive rather than proactive to unstable conditions. In this dissertation, we propose control frameworks that preserve voluntary human motion while addressing two major challenges: providing task-agnostic assistance …

Quantifying The Value Of Adaptability: Bridging Real Options Analysis And Adaptable Building Design, Miranda Grice

All Dissertations

As the demands of the built environment continually evolve, buildings are expected to meet changing occupancy needs, or otherwise they become obsolete. Despite positive research on the benefits of adaptable building design, there is a knowledge gap regarding the long-term economic benefits of these designs. Practical methods are needed to determine if premium costs associated with adaptable designs are justified by the economic benefits inherent in adaptability. Therefore, this dissertation provides a discussion on the application of the financial theory of options analysis to the design of adaptable buildings. Additionally, a model and accompanying tool are presented as a solution …

Optimal Allocation Of Flexible Servers In Healthcare Systems, Tong Zhang

All Dissertations

This dissertation investigates the optimization of worker allocation in healthcare systems, focusing on flexible staffing models and the strategic prioritization of healthcare tasks. This research explores the dynamics among pre-operative, operative, and post-operative care units under various cost and service-rate constraints, using a series of models that represent realistic healthcare scenarios within a comprehensive framework for improving patient flow and reducing waiting costs.

In Chapter 2, we model and analyze cross-trained nurse allocation policies within an inpatient surgical system. We model the surgical system as a tandem clearing queueing system and formulate Markov decision processes under different business rules governing …

Side-To-Side Differences In Three-Dimensional Femoral Head Coverage Associated With Initial Symptom Development In Patients With Bilateral Developmental Dysplasia Of The Hip, Jiayi Sun

McKelvey School of Engineering Graduate Student Theses & Dissertations

Developmental dysplasia of the hip (DDH) is characterized by insufficient acetabular coverage of the femoral head and is a recognized cause of hip pain, instability, and early osteoarthritis. Although bilateral deformity is common, symptoms often first develop in only one hip. The purposes of this study were: (1) to determine whether, in patients with bilateral DDH, side-to-side differences in three-dimensional (3D) femoral head coverage vary according to radiographic symmetry defined by the lateral center-edge angle (LCEA); and (2) to determine whether hips that appear radiographically symmetric still demonstrate focal 3D asymmetry.

This retrospective imaging-based study included patients with bilateral DDH …

Establishing Caenorhabditis Elegans As A Platform For Bioaccumulation And Selectivity Screening Of Anthelmintic Compounds, Jiarui Li

McKelvey School of Engineering Graduate Student Theses & Dissertations

To address the cuticular barrier in anthelmintic discovery, this study establishes a bifurcated framework in Caenorhabditis elegans. First, HPLC-based quantification of 14 PIM inhibitors revealed that cuticular penetrance is primarily dictated by phylogenetic lineage (Clade V) rather than ecological niche. Specifically, C. elegans demonstrated a significant pharmacokinetic correlation with the hookworm Ancylostoma ceylanicum (Clade V) but not the whipworm Trichuris muris (Clade I), validating it as a superior surrogate model for hookworm bioaccumulation. Within this small molecule inhibitor library, SGI-12was identified as a lead candidate with superior potency against C. elegans and bioaccumulation. Second, target validation using a C. …

Multiscale Architecture Governs Stability In Suction-Actuated Variable Stiffness Catheters, Sheridan Lee

McKelvey School of Engineering Graduate Student Theses & Dissertations

Endovascular procedures require devices with widely varying mechanical properties: flexibility for navigating tortuous vessels and rigidity for stable therapeutic delivery. Suction-actuated variable stiffness sheaths address this challenge by incorporating axial wire string arrays that mechanically couple under suction to increase flexural rigidity. However, prototype devices achieve stiffening ratios below theoretical predictions, suggesting that interlayer mechanics and string positioning play a critical role. This study investigates whether interweaving polytetrafluoroethylene (PTFE) tape within the string array enhances flexural rigidity modulation and curvature stability. Prototype devices with varying wrap configurations were fabricated and evaluated using flexural testing, curvature stability testing, and mathematical modeling. …

Computational Fluid Dynamics (Cfd)-Based Performance Prediction Of Transcatheter Microvascular Plugs In Single-Ventricle Patients, Zhuhuan Zou

McKelvey School of Engineering Graduate Student Theses & Dissertations

Transcatheter palliation using fenestrated Modified Micro Vascular Plugs (MVP) has emerged as a promising, minimally invasive alternative to surgical pulmonary artery banding (PAB) for high-risk neonates with single-ventricle physiology. However, clinical applications are currently limited by the difficulty in predicting the resulting pulmonary-to-systemic flow ratio () and the lack of a standardized approach for selecting the optimal fenestration size. This study utilizes patient-specific computational fluid dynamics (CFD) to quantitatively evaluate the impact of varying fenestration diameters on circulatory balance. Patient-specific 3D models of the pulmonary artery (PA) were reconstructed from imaging data for two clinical cases using SimVascular. Transient CFD …

Low-Cost Rf Exposure Monitoring With Tinyml Prediction, Sanad Sahawneh

Nanoscale Science & Engineering (discontinued with class year 2014)

The proliferation of wireless technologies has produced a dense, increasingly heterogeneous radio-frequency (RF) environment that surrounds modern life. While regulatory bodies such as the Federal Communications Commission (FCC) and the World Health Organization (WHO) maintain exposure guidelines, the tools that ordinary people, educators, and small institutions can use to actually observe RF exposure in their own spaces remain expensive, specialized, and largely confined to professional laboratories. Spectrum analyzers and calibrated field probes routinely cost between five hundred and one hundred thousand dollars per unit, placing continuous local monitoring out of reach for most environments where exposure questions are most natural …

A New Approach To Generate Combinatorial Patterns In Logical Analysis Of Data And Its Application To Predict College Retention, Salihah Ahmed E. Jaafari

Theses and Dissertations

Student retention and degree completion remain central challenges for higher-education institutions, with significant implications for student success, institutional effectiveness, and public accountability. While advances in predictive analytics have enabled earlier identification of students at risk of withdrawal, many commonly used machine learning approaches suffer from limited interpretability, constraining their practical usefulness for advising, intervention, and policy decision making. This dissertation addresses the problem of predicting student persistence by developing and evaluating optimization based, interpretable classification models within the Logical Analysis of Data (LAD) framework. Building on existing LAD formulations, this research introduces two novel pattern generation models, the Best Term …

Design And Simulation Of Anti-Resonant Hollow-Core Fiber For Sensing Applications, Pravallika Kante

Theses and Dissertations

This thesis presents the design and simulation of an 8-tube single-ring anti-resonant hollow-core fiber for sensing applications, with particular emphasis on methane gas detection at the fundamental absorption wavelength of 3.3 µm. Conventional solid-core silica optical fibers exhibit strong multi-phonon material absorption beyond 2.5 µm, rendering them fundamentally unsuitable for efficient light guidance and direct gas sensing at mid-infrared wavelengths. Anti-resonant hollow-core fibers overcome this limitation by guiding light predominantly through an air-filled hollow core via the anti-resonant reflecting optical waveguide mechanism, in which the thin silica glass walls of the cladding tubes act as Fabry-Pérot etalons that confine the …

Tribological Evaluation Of A Graphite Coating Using A Custom Miniature Conveyor, Shae Threlfall

Mechanical Engineering Undergraduate Honors Theses

Reducing friction in conveyor systems has significant economic and environmental implications, as a substantial portion of energy losses originates at the belt-bed interface. This thesis outlines the design, construction, and validation of a miniature conveyor tribological test system. Unlike conventional tribometers, which impose concentrated point contacts, the miniature conveyor replicates the distributed load consistent with industrial conveyor systems. It can measure real-time mechanical responses of steel samples coated in a low friction coating.

The mini conveyor was validated by evaluating three materials: uncoated mild steel, PDA/graphite coated steel, and Polytetrafluoroethylene (PTFE). Electrical power, temperature, sound, and acceleration were recorded. Electrical …

Behavior Of A Mildly Skewed Network Tied-Arch Bridge During Construction And Early Service Life, Harsha Amunugama

Dissertations

This dissertation work investigated the structural performance of the 2nd Avenue Bridge in Detroit, Michigan, the first skewed, unbraced network tied-arch bridge in the U.S. The 245-ft long, 96.5-ft wide bridge features an 18-degree skew. The bridge was constructed using accelerated bridge construction (ABC) techniques, including off-site fabrication at a bridge staging area (BSA) and installation via self-propelled modular transporters (SPMTs) and lateral launching, enabling the completion of construction with minimal disruptions to I-94 traffic and improved safety.

Given the unique structural configuration of the bridge, the use of innovative construction techniques, and differences observed in structural responses predicted by …

Ai-Based Framework For Elucidating The Ring Opening Energy Of Cycloalkanes, Evan Griffin

Open Access Theses & Dissertations

Cycloalkanes are a prominent component of jet fuels due to their high volumetric energy density and lower soot yield compared to aromatics. However, the structural nuance of cycloalkanes can make predicting their combustion kinetics challenging. The present study aims to develop a quantitative structure-property relationship of the ring opening energy (ROE) of cycloalkanes. A total of 253 cycloalkanes were curated from the ZINC15 database, ranging from monocycloalkanes to tetra-cycloalkanes. The 3-D cartesian coordinates of the closed shell and open shell diradical states for all curated cycloalkanes was generated with RDKit in Python and used MMFF94 to optimize the molecular geometries. …

A Systems Engineering-Based Method For Enabling Digital Transformation In A Binational Small Healthcare Enterprise, Manuel Adrian Alvarez Ramirez

Open Access Theses & Dissertations

The year 2020, often described as "the great accelerator" for emerging technologies, marked a period of significant transformation in lifestyles, work patterns, and business strategies. For instance, online meetings have become more convenient than in-person interactions, even with colleagues in neighboring offices. For small businesses, rapid regulatory and technological changes required swift adaptation, including the acquisition of new technologies, tools, and software to ensure survival. This transition also necessitated adopting indirect engagement, revising communication protocols, and digitally transforming information. Small and Medium-sized Enterprises (SMEs) in essential service sectors face also a fundamental paradox: their dependence on the skills, relationships, and …

Simultaneous Carrier, Cargo, And Functional Tracking Of Lipid Nanoparticles, Hannia Vanessa Balcorta Muñoz

Open Access Theses & Dissertations

Lipid nanoparticles (LNPs) have become effective delivery vehicles in nanomedicine, particularly for nucleic acid-based treatments. However, a major limitation remains in the field regarding the simultaneous monitoring of the nanoparticle carrier, its encapsulated payload, and the resulting functional protein production in both in vitro and in vivo systems. Furthermore, traditional lipophilic dyes employed for labeling LNPs frequently exhibit incompatibility with tissue-clearing methods, such as CLARITY, due to signal loss following lipid removal. This research developed and evaluated a new fluorescent labeling method using CM-DiI, a dye that reacts with thiols, for multimodal tracking of LNPs. CM-DiI was included in the …

A Low-Cost Motion Classification System For A Stuffed Animal Using An Imu And Machine Learning, Rachel N. Guynes

Honors Theses

One of the many fields that has seen the integration of robots is therapy. Zoomorphic robots (ZR) are designed to look and behave like animals to assist in Animal Assisted Therapy (AAT) practices. Studies show that ZRs can provide benefits similar to working with an actual animal; however, their high cost limits their accessibility. This thesis documents the process of building a real-time, low-cost motion classification system that can be attached to a stuffed animal to make it more interactive. Using a Random Forest (RF) classifier, the system identifies movements with approximately 81.67% accuracy.

Intelligent Manufacturing Of Edible Oil: From Smart Sensing To Big Data Platform, Ru Jiang, Nadirbek Yusupbekov

Chemical Technology, Control and Management

With the rapid advancement of Industry 4.0 technologies, intelligent manufacturing and big data platforms are profoundly transforming the production models of the traditional edible oil industry. The edible oil production process involves multiple complex unit operations such as refining, decolorization, and deodorization, which impose high requirements on process control and product quality monitoring. This paper presents a systematic review of key technological advances in the field of intelligent manufacturing of edible oil, establishing a comprehensive technical framework encompassing four dimensions: smart sensing, artificial intelligence applications, IoT communication, and big data platforms. The review begins by analyzing the global background and …

Quantitative Fluorescence Imaging Using A Paired Agent Approach For Improving Surgical Decision Making, Sanjana Pannem

Dartmouth College Ph.D Dissertations

Surgical resection remains to be the cornerstone of treatment for most solid tumors, where the primary objective is to remove all visible and microscopic disease. However, the extent of tumor resection is inherently limited by the surgeon’s ability to distinguish tumor from normal tissue, intraoperatively. As a result, positive surgical margins (PSM), where residual tumor remains after surgery, are a common occurrence and are associated with increased recurrence, need for adjuvant therapies, dismal patient outcomes, and high healthcare costs.

Fluorescence guided surgery (FGS) has emerged as a promising technique to enhance intraoperative visualization of tumors and may help reduce the …

Uncertainty Handling In Stock Market Prediction: A Fuzzy Markov Chain Approach, Alpa Singh Rajput, Arpan Singh Rajput

Neutrosophic Systems with Applications

Predicting the stock market is never easy because it is influenced by many uncertain and constantly changing factors such as economic conditions, investor behaviour, and global events. Traditional models like the Crisp Markov Chain (CMC) try to predict market movements by using fixed probabilities for different states like bullish, bearish, or stagnant. However, real markets do not behave in such a strict way—they often move gradually between states, which these models fail to capture. To overcome this limitation, this study introduces a Fuzzy Markov Chain (FMC) model, where fuzzy logic is used to handle uncertainty and allow smoother transitions between …

Modeling Agentic Artificial Intelligence Uncertainty In Agriculture Based 6generation: A Hybrid Q-Rung Orthopair Fuzzy Mcdm Methodology, Zekra Sakr, Mona Mohamed

Neutrosophic Systems with Applications

In era of advanced intelligent revolutions, the collaboration between intelligent technologies became imperative. For instance, integrating 6G communications with agentic artificial intelligence considered a catalyst to shift agriculture sector into optimized and intelligence sector. This integration resulted in transitioning the sector from static automation to autonomous, agent-based ecosystems. Accordingly, the efficiency roles for artificial intelligence agents (AIAs), deploying and selecting optimal AIA is important. Yet, selection process is still difficult because agricultural criteria are multifaceted and there are inherent environmental uncertainties. To address these challenges and bolster the selection process, this paper suggests a hybrid multi-criteria decision-making (MCDM) that bolstered …

Implementation Of Kansei Engineering Method In Designing Spreadable Cheese Packaging, Novi Purnama Sari, Mega Analisa, Suci Puji Lestari, Khofifah Nur Amalia

Makara Journal of Technology

Some spreadable cheese packaging uses flexible plastic without additional features and easily damaged boxes. This packaging causes several problems, such as difficulty in re-storage, loss of product information due to damaged box packaging, wasteful use of packaging materials, and making the product less hygienic. The purpose of this study is to develop packaging that focuses on consumer emotions. The packaging was developed using the Kansei Engineering method, supported by Principal Component Analysis (PCA) as a determinant of the design concept, and Quantification Theory Type 1 (QTT1) to identify design elements. This study produced 46 packaging samples and 40 Kansei words. …

Picc-Pal: A Support Band For Independent Picc Line Use, Kylie Luker

Honors Theses

This project presents the design and evaluation of PICC-PAL, a wearable assistive device intended to improve independence and usability for patients managing peripherally inserted central catheters (PICC lines) at home. Current at-home PICC line management often requires help due to the fine motor skills needed to connect and secure tubing. This increases reliance on caregivers and introduces potential risks such as infection and dislodgement. Through stakeholder analysis, prior art evaluation, and iterative prototyping, a device was developed to stabilize the PICC line lumen and enable one-handed connection of medical tubing. Throughout the project, multiple design concepts were explored, with the …

Conceptual Model For Protecting Personal Data By Depersonalization In Information Systems: Principles, Components, And Life Cycle, Zarina Ildarovna Azizova

Chemical Technology, Control and Management

This article presents a systematic approach to personal data protection through depersonalization in the context of regulatory pressure and growing cyber threats. It proposes a comprehensive conceptual model that formalizes the de-identification process as a manageable sequence of steps, from attribute classification and method selection to mandatory verification of the result. The article also provides a comparative analysis of existing depersonalization methods in terms of their applicability within the proposed model. The model serves as a basis for the development of specific algorithms, as demonstrated by the example of a data shuffling approach.

The Impact Of People Interests In Evaluating The Open Public Spaces' Quality In The City Centre, Hasan Hadi, Adil Al-Saidi, Haitham Alshamari

HBRC Journal

The quality of open public spaces in city centres significantly affects people's satisfaction and responses to their built environment. The significance of these areas allow people to assess their performance. this paper addresses the issue of People's interests that affect their evaluation of public urban spaces in city centres. The research applied an ontological methodology that is people's experiences determine the spatial quality of the public spaces in city centres. In order to discover and assess the seven value variables, it recommended diagnosing a random sample of users as a group (A) and (B). The urban space in the historic …

Improving Transfer Portal Decision-Making Through A Microsoft Excel Optimization Model, Peyton Steffes

Honors Projects

The creation of the transfer portal has increased the mobility of collegiate athletes, giving players the autonomy to switch teams throughout their career. As a result, the roster development process has become more complex, as coaches are tasked with the challenge of recruiting from the transfer portal, which involves an extensive decision-making process. Coaches not only have to evaluate a substantial pool of players, but they also must consider the following constraints they are under: scholarship budget, roster spots available, and positional needs. To simplify this decision-making process, this analysis includes the results of a Microsoft Excel data optimization model …

Multicriteria Analysis Of Vehicle Exhausts Emission Using Fuzzy Analytic Hierarchy, Sunday Ayoola Oke, Ibraheem Adedotun Abdul, Ismaila Badmus, John Rajan, Swaminathan Jose, Adekunle Adetayo Yekinni, Kabiru Alani Olaiya, Mofoluwaso Kehinde Adeniran, Pandiaraj Benrajesh

Makara Journal of Technology

This study employs the fuzzy analytic hierarchy process (FAHP) to identify the critical factors and their degree of relevance to the vehicle emission process. Its innovation lies in the potential to blend ambiguity and uncertainty with the established AHP. FAHP transforms information into a defuzzification state through signal-to-noise ratios, normalization, and pairwise comparison. The principal parameters considered are revenue, sold packing units, CAGR, packing materials, consumption, and CO2 emissions (A, B, C, D, E, and F, respectively). From the normalized defuzzified weight result, consumption (Parameter E) is the best (normalized weight, 0.8685917), while CO2 emissions (Parameter F) was the worst …