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The Contribution Of Outcome Expectation In Water Saving Among Malaysians For Sustainable Living Standard, Ganesh. R, Vxynette Fiorna, Ammar Abdulaziz Al-Talib, Haslinda. A, Elango Natarajan Jan 2024

The Contribution Of Outcome Expectation In Water Saving Among Malaysians For Sustainable Living Standard, Ganesh. R, Vxynette Fiorna, Ammar Abdulaziz Al-Talib, Haslinda. A, Elango Natarajan

ASEAN Journal on Science and Technology for Development

Saving water is an essential component of a higher level of living for each individual in any Nation. The current and next generation will be greatly impacted by attitudes and emotional aspects of social cognitive behaviour. This empirical investigation was carried out in Malaysia. To determine their attitude and behaviour, a convenience sampling method was applied to a sample size of 265 individuals. It was discovered that outcome expectancy significantly improves water saving. Observed self-efficacy, personal elements, and environmental elements all impacted the outcome expectancy. The model evaluation showed that the adjusted R2 was 0.78, or about 78% of the …


Enhancing Phishing Attack Detection Using Explainable Ai: Trends And Innovations, Bhagyashree D. Shendkar, Pankaj R. Chandre, Sulochana Sagar Madachane, Nikita Kulkarni, Sayalee Deshmukh Jan 2024

Enhancing Phishing Attack Detection Using Explainable Ai: Trends And Innovations, Bhagyashree D. Shendkar, Pankaj R. Chandre, Sulochana Sagar Madachane, Nikita Kulkarni, Sayalee Deshmukh

ASEAN Journal on Science and Technology for Development

In the context of escalating cyber threats, phishing attacks continue to pose significant challenges to cybersecurity measures, exploiting human vulnerabilities to gain unauthorized access to sensitive information. Innovative solutions are required because traditional detection methods frequently fail to identify and mitigate these assaults successfully. To improve phishing attack detection, this study makes use of Explainable Artificial Intelligence (AI) tools, which provide decision-making processes with transparency and prediction accuracy. The paper begins by outlining the pervasive nature of phishing attacks in today's digital landscape, emphasizing their detrimental impact on individuals, organizations, and society at large. It then discusses the limitations of …


Economic Profitability Of Sustainable Buildings Industry, Mohanad Ibrahim Altuma, Hanadi Abdulridha Lateef, Ayad Abdulkhaleq Al-Yousuf Jan 2024

Economic Profitability Of Sustainable Buildings Industry, Mohanad Ibrahim Altuma, Hanadi Abdulridha Lateef, Ayad Abdulkhaleq Al-Yousuf

Al-Esraa University College Journal for Engineering Sciences

The increasing global awareness of the Earth's deteriorating condition and the unpredictable effects of climate change has given rise to worldwide phenomena that impact several elements like the economy, agricultural security, water availability, and energy supplies. Buildings contribute significantly to the generation of greenhouse gases, as well as the disposal of pollutants and energy consumption. Therefore, they play a crucial role in addressing environmental issues.

Although sustainable buildings are widely acknowledged as a potential advancement, professionals in the property market still believe that the upfront costs of creating sustainable buildings are significantly higher than those of conventional buildings. This view …


Machine-Learning-Assisted Design Of Deep Eutectic Solvents Based On Uncovered Hydrogen Bond Patterns, Usman Lame Abbas, Yuxuan Zhang, Joseph Tapia, Md Selim, Jin Chen, Jian Shi, Qing Shao Jan 2024

Machine-Learning-Assisted Design Of Deep Eutectic Solvents Based On Uncovered Hydrogen Bond Patterns, Usman Lame Abbas, Yuxuan Zhang, Joseph Tapia, Md Selim, Jin Chen, Jian Shi, Qing Shao

Markey Cancer Center Faculty Publications

Non-ionic deep eutectic solvents (DESs) are non-ionic designer solvents with various applications in catalysis, extraction, carbon capture, and pharmaceuticals. However, discovering new DES candidates is challenging due to a lack of efficient tools that accurately predict DES formation. The search for DES relies heavily on intuition or trial-and-error processes, leading to low success rates or missed opportuni- ties. Recognizing that hydrogen bonds (HBs) play a central role in DES formation, we aim to identify HB features that distinguish DES from non-DES systems and use them to develop machine learning (ML) models to discover new DES systems. We first analyze the …


Perfluorooctanesulfonic Acid Exposure Leads To Downregulation Of 3-Hydroxy-3-Methylglutaryl-Coa Synthase 2 Expression And Upregulation Of Markers Associated With Intestinal Carcinogenesis In Mouse Intestinal Tissues, Josiane Weber Tessmann, Pan Deng, Jerika Durham, Chang Li, Moumita Banerjee, Qingding Wang, Ryan A. Goettl, Daheng He, Chi Wang, Eun Y. Lee, B. Mark Evers, Bernhard Hennig, Yekaterina Y. Zaytseva Jan 2024

Perfluorooctanesulfonic Acid Exposure Leads To Downregulation Of 3-Hydroxy-3-Methylglutaryl-Coa Synthase 2 Expression And Upregulation Of Markers Associated With Intestinal Carcinogenesis In Mouse Intestinal Tissues, Josiane Weber Tessmann, Pan Deng, Jerika Durham, Chang Li, Moumita Banerjee, Qingding Wang, Ryan A. Goettl, Daheng He, Chi Wang, Eun Y. Lee, B. Mark Evers, Bernhard Hennig, Yekaterina Y. Zaytseva

Markey Cancer Center Faculty Publications

Perfluorooctanesulfonic acid (PFOS) is a widely recognized environment pollutant known for its high bio- accumulation potential and a long elimination half-life. Several studies have shown that PFOS can alter multiple biological pathways and negatively affect human health. Considering the direct exposure to the gastrointestinal (GI) tract to environmental pollutants, PFOS can potentially disrupt intestinal homeostasis. However, there is limited knowledge about the effect of PFOS exposure on normal intestinal tissues, and its contribution to GI- associated diseases remains to be determined. In this study, we examined the effect of PFOS exposure on the gene expression profile of intestinal tissues of …


Investigation Of Delta-Focused Ictal Electrical Source Imaging In Refractory Focal Epilepsy, Jared A. Rybarczyk Jan 2024

Investigation Of Delta-Focused Ictal Electrical Source Imaging In Refractory Focal Epilepsy, Jared A. Rybarczyk

Theses and Dissertations--Electrical and Computer Engineering

Refractory focal epilepsy is characterized by the presence of seizures that cannot be controlled via anti-seizure medications. For patients suffering from this form of epilepsy, accurate identification of the seizure onset zone is a crucial step for many modalities of treatment. Electrical source imaging (ESI) allows for estimation of the seizure onset zone from electroencephalography. EEG feature extraction is an important step that can impact the final accuracy of source estimates. This work provides a review of 23 ictal ESI studies and proposes a delta-focused ictal ESI methodology. Our proposed delta-focused ictal ESI is implemented across 33 refractory focal epilepsy …


Nonuniform Sampling-Based Breast Cancer Classification, Santiago Posso Jan 2024

Nonuniform Sampling-Based Breast Cancer Classification, Santiago Posso

Theses and Dissertations--Electrical and Computer Engineering

The emergence of deep learning models and their success in visual object recognition have fueled the medical imaging community's interest in integrating these algorithms to improve medical diagnosis. However, natural images, which have been the main focus of deep learning models and mammograms, exhibit fundamental differences. First, breast tissue abnormalities are often smaller than salient objects in natural images. Second, breast images have significantly higher resolutions but are generally heavily downsampled to fit these images to deep learning models. Models that handle high-resolution mammograms require many exams and complex architectures. Additionally, spatially resizing mammograms leads to losing discriminative details essential …


High Reliability Motor-Drive Systems For Electric Aircraft Propulsion, Majid Tahmasbi Fard Jan 2024

High Reliability Motor-Drive Systems For Electric Aircraft Propulsion, Majid Tahmasbi Fard

Theses and Dissertations--Electrical and Computer Engineering

The transition towards electric propulsion in aircraft applications requires significant advancements in enhancing the efficiency and power density of power transmission and distribution systems. Among the critical power components in electric aircraft propulsion systems, power electronic converters hold paramount importance as they provide a pivotal interface between batteries and propulsion motors while providing a high degree of controllability and flexibility to the system. Integrating medium voltage DC (MVDC) and the emerging wide bandgap switching devices into power converters not only amplifies converter performance but also unlocks multifarious system-level benefits, including reduced power losses, weight savings, and the utilization of high-speed …


Vertical Farming: A Key To Sustainable Compact Cities, Mohab Taher Abdelfatah, Sahar Mahmoud El-Arnaouty, Akram Abdelhakim Zayan Jan 2024

Vertical Farming: A Key To Sustainable Compact Cities, Mohab Taher Abdelfatah, Sahar Mahmoud El-Arnaouty, Akram Abdelhakim Zayan

Mansoura Engineering Journal

Urbanization continues to surge, with projections indicating that by 2050, around 70 percent of the global population will reside in urban areas. In response, urban planners are exploring novel urban paradigms to ensure food security through urban agriculture, a cornerstone of sustainable development encompassing environmental, economic, and social dimensions. This study addresses a critical research gap within urban agriculture, conducting a comparative analysis between horizontal and vertical farming methodologies within urban contexts. By categorizing various typologies of vertical farming, from container farms to mixed-use structures, this research highlights their distinct contributions to sustainable urban development. Emphasis is placed on vertical …


The Impact Of Social Media On Charitable Giving For Nonprofit Organization, Namchul Shin Jan 2024

The Impact Of Social Media On Charitable Giving For Nonprofit Organization, Namchul Shin

Journal of International Technology and Information Management

Research has extensively studied nonprofit organizations’ use of social media for communications and interactions with supporters. However, there has been limited research examining the impact of social media on charitable giving. This research attempts to address the gap by empirically examining the relationship between the use of social media and charitable giving for nonprofit organizations. We employ a data set of the Nonprofit Times’ top 100 nonprofits ranked by total revenue for the empirical analysis. As measures for social media traction, i.e., how extensively nonprofits draw supporters on their social media sites, we use Facebook Likes, Twitter Followers, and Instagram …


How Does Digitalisation Transform Business Models In Ropax Ports? A Multi-Site Study Of Port Authorities, Yiran Chen, Anastasia Tsvetkova, Kristel Edelman, Irina Wahlström, Marikka Heikkila, Magnus Hellström Jan 2024

How Does Digitalisation Transform Business Models In Ropax Ports? A Multi-Site Study Of Port Authorities, Yiran Chen, Anastasia Tsvetkova, Kristel Edelman, Irina Wahlström, Marikka Heikkila, Magnus Hellström

Journal of International Technology and Information Management

This article investigates the relationship between digitalisation and business model changes in RoPax ports. The study is based on six RoPax ports in Northern Europe, examining their digitalisation efforts and the resulting changes in their business models, leading to further digital transformation. The paper offers insights by reviewing relevant literature on digitalisation’s role in business model innovation and its application in ports. The findings reveal that digitalisation supports relevant business model changes concerning port operation integration within logistics chains, communication, documentation flow, and cargo flow optimisation. However, exploring digitalisation’s potential for diversifying value propositions is still limited. Most digitalisation efforts …


Key Issues Of Predictive Analytics Implementation: A Sociotechnical Perspective, Leida Chen, Ravi Nath, Nevina Rocco Jan 2024

Key Issues Of Predictive Analytics Implementation: A Sociotechnical Perspective, Leida Chen, Ravi Nath, Nevina Rocco

Journal of International Technology and Information Management

Developing an effective business analytics function within a company has become a crucial component to an organization’s competitive advantage today. Predictive analytics enables an organization to make proactive, data-driven decisions. While companies are increasing their investments in data and analytics technologies, little research effort has been devoted to understanding how to best convert analytics assets into positive business performance. This issue can be best studied from the socio-technical perspective to gain a holistic understanding of the key factors relevant to implementing predictive analytics. Based upon information from structured interviews with information technology and analytics executives of 11 organizations across the …


Does Personality Traits And Security Habits Influence Security Of Personal Identification Numbers? The Context Of Mobile Money Services In Tanzania., Daniel Ntabagi Koloseni Jan 2024

Does Personality Traits And Security Habits Influence Security Of Personal Identification Numbers? The Context Of Mobile Money Services In Tanzania., Daniel Ntabagi Koloseni

Journal of International Technology and Information Management

Security is an important ingredient in financial transactions; as such, it is imperative that attention should be paid to enhancing the security habits and user behaviours of mobile payment services. Establishing a link between security habits, personality characteristics, and security behaviours provides a new dimension to studying security behaviours regarding mobile money services. Therefore, this study investigates how personality traits affect security behaviours and habits and how security habits mediate the link between personality traits and PIN security practices. The study found that conscientiousness, openness to experience, extroversion and security habits influence PIN security practices, while conscientiousness, agreeableness, and neuroticism …


Media And Internet Censorship In India: A Study Of Its History And Political-Economy, Ramesh Subramanian Jan 2024

Media And Internet Censorship In India: A Study Of Its History And Political-Economy, Ramesh Subramanian

Journal of International Technology and Information Management

The Indian Constitution, which came into force on January 26, 1950, guarantees various fundamental rights, such as the freedom of speech and expression, freedom of religion, rights to form association, as well as rights to privacy. Yet, since the adoption of the Constitution, the Indian citizen has been subject to varying degrees of media censorship and surveillance. This paper seeks to delve into the historical evolution of media and Internet censorship and surveillance in India. It shows how media censorship of varying types have existed since the British colonists introduced restrictive laws in order to expand and control the native …


Activities Tailoring Within Agile Scrum Roles: A Case Of Nigerian Healthcare Information Systems Development, Yazidu Salihu, Julian Bass, Gloria Iyawa Jan 2024

Activities Tailoring Within Agile Scrum Roles: A Case Of Nigerian Healthcare Information Systems Development, Yazidu Salihu, Julian Bass, Gloria Iyawa

Journal of International Technology and Information Management

Developing quality agile healthcare information systems requires understanding regulatory compliance and evolving healthcare needs through activities tailored within agile scrum roles. Agile scrum, a widely adopted philosophy, offers significant advantages in managing software development processes. This research explores how activities within the agile scrum roles are tailored to agile healthcare information systems development within the Nigerian context. This study adopted a qualitative case study methodology and interviewed 12 agile practitioners developing healthcare information systems within Nigeria using semi-structured open-ended interview guide questions. The practitioners were selected based on a snowballing process, a sunset of purposive sampling techniques from our network …


A Validation Of Wepp Water Quality Routines In Uniform And Nonuniform Agricultural Hillslopes, Ryan P. Mcgehee, Dennis C. Flanagan, Bernard A. Engel, John E. Gilley Jan 2024

A Validation Of Wepp Water Quality Routines In Uniform And Nonuniform Agricultural Hillslopes, Ryan P. Mcgehee, Dennis C. Flanagan, Bernard A. Engel, John E. Gilley

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Nutrients in agricultural runoff may cause offsite environmental impacts. The objective of this investigation was to examine nutrient transport by overland sheet flow on sites containing swine slurry. Data examined in this study was collected during field rainfall simulation tests conducted on cropland sites in southeast Nebraska, USA. Inflow was added to the top of experimental plots in four successive increments to simulate runoff rates occurring at greater downslope distances. Runoff rates on the experimental sites ranged from 2.3 to 21.2 L min 1 and maximum equivalent downslope distances varied from 5 to 108 m. Phosphorus (P) and nitrogen (N) …


Salmonella Detection In Food Using A Hek-Htlr5 Reported Cell-Based Sensor, Esma Eser, Victoria A. Felton, Rishi Drolia, Arun K. Bhunia Jan 2024

Salmonella Detection In Food Using A Hek-Htlr5 Reported Cell-Based Sensor, Esma Eser, Victoria A. Felton, Rishi Drolia, Arun K. Bhunia

Biological Sciences Faculty Publications

The development of a rapid, sensitive, specific method for detecting foodborne pathogens is paramount for supplying safe food to enhance public health safety. Despite the significant improvement in pathogen detection methods, key issues are still associated with rapid methods, such as distinguishing living cells from dead, the pathogenic potential or health risk of the analyte at the time of consumption, the detection limit, and the sample-to-result. Mammalian cell-based assays analyze pathogens’ interaction with host cells and are responsive only to live pathogens or active toxins. In this study, a human embryonic kidney (HEK293) cell line expressing Toll-Like Receptor 5 (TLR-5) …


Receptor-Targeted Next-Generation Probiotics Ameliorate Mammalian Colitis, Nicholas L. F. Gallina, Vignesh Nathan, Akshay Krishnakumar, Dongqi Liu, Rishi Drolia, Nicole Irrizary Tardi, Yang Fu, Manalee Samadar, Shivendra Tenguria, Alvin Cai, Ruth Eunice Centeno-Martinez, Timothy A. Johnson, Abigail Cox, Lavanya Reddivari, Bruce Applegate, Xingjian Bai, Luping Xu, Deepti Tanjore, Ramesh Vemulapalli, Rahim Rahimi, Arun K. Bhunia Jan 2024

Receptor-Targeted Next-Generation Probiotics Ameliorate Mammalian Colitis, Nicholas L. F. Gallina, Vignesh Nathan, Akshay Krishnakumar, Dongqi Liu, Rishi Drolia, Nicole Irrizary Tardi, Yang Fu, Manalee Samadar, Shivendra Tenguria, Alvin Cai, Ruth Eunice Centeno-Martinez, Timothy A. Johnson, Abigail Cox, Lavanya Reddivari, Bruce Applegate, Xingjian Bai, Luping Xu, Deepti Tanjore, Ramesh Vemulapalli, Rahim Rahimi, Arun K. Bhunia

Biological Sciences Faculty Publications

Introduction: a loss of intestinal barrier function, inflammation, and an elevated expression of epithelial heat shock protein 60 (Hsp60) are features of an inflamed bowel. Probiotics have been used to alleviate colitis-induced pathologies, but offer poor adhesion and adaptation to the diseased gut. We hypothesize that enhancing probiotic adhesion in the inflamed bowel may ameliorate such pathologies. Listeria adhesion protein (LAP; 94-kDa acetaldehyde alcohol dehydrogenase) aids Listeria attachment to the epithelial cells by interacting with the mammalian receptor Hsp60. Bioengineered Lactobacillus casei probiotics (BLPs) expressing LAP showed strong interaction with epithelial Hsp60, a high immunomodulatory response, and sustained epithelial barrier …


Deciphering Speech Through Vision: A Deep Learning Lip Reading System, Srujith Rao Ambati Jan 2024

Deciphering Speech Through Vision: A Deep Learning Lip Reading System, Srujith Rao Ambati

Master's Projects

Lip-reading, a ubiquitous field between computer vision and speech processing, focuses on identifying what spoken words a person generates depending on their uttering lip movements. This paper presents a streamlined lip-reading solution that employs machine learning and deep learning. First, Our work utilizes the Multi-Task Cascaded Convo- lutional Networks to detect facial “landmarks,” including the face and lips region, and the aligns the face. The aligned faces are segmented to get the lip images. Lip images are preprocessed using the Real-Enhanced Super Resolution Generative Adversarial Network to enhance image resolution to identify subtle lip movement in video images: a critical …


Multi-Platform Cyberbullying Detection Using Nlp And Machine Learning, Chinmayi Lokeshwar Hegde Jan 2024

Multi-Platform Cyberbullying Detection Using Nlp And Machine Learning, Chinmayi Lokeshwar Hegde

Master's Projects

The issue of cyberbullying is growing due to the online anonymity and due to online platforms having less repercussions. This research proposes for proactive measures to detect and prevent such behavior before it reaches the victim. By using data from various social media platforms and employing machine learning techniques, this research proposes an innovative system aimed at identifying and thwarting cyberbullying incidents preemptively. While existing methods have primarily focused on prediction and detection of cyberbullying incidents, there remains a significant gap in research regarding prevention strategies. This project aims to address this gap by leveraging machine learning, natural language processing …


Detecting Crustose Coralline Algae (Cca) In Marine Photos Using Mask R-Cnn, Vrushali Harshwardhan Deshpande Jan 2024

Detecting Crustose Coralline Algae (Cca) In Marine Photos Using Mask R-Cnn, Vrushali Harshwardhan Deshpande

Master's Projects

Coral reefs, made up of thousands of polyps - tiny sac-like marine invertebrates sea anemones and jellyfish, are important to marine ecosystems and prevent loss of life by acting as a natural barrier against storms, floods, and waves. These reefs support a wide range of species, many of which are underexplored and new species being discovered regularly. Crustose coralline algae (CCA) is one of the vital algal species that provides reef structure. Studying the abundance of CCA is important in helping marine biologists analyze coral reef health while understanding the impact of climate change on the marine lifeforms. This study …


Exploring Fluctuations In Working Memory Load Through Pupillometry Using Gabor Image Deletion Tasks, Neenu Antony Jan 2024

Exploring Fluctuations In Working Memory Load Through Pupillometry Using Gabor Image Deletion Tasks, Neenu Antony

Master's Projects

Van der Wel & Van Steenbergen mention that there has been a surge in pupillometry research in the past two decades, particularly in the area of task-evoked pupil dilation in the context of cognitive control tasks. The goal of most of these studies has been focused on finding a link between pupil dilation and effort exerted by an individual [10]. The review by authors Van der Wel & Van Steenbergen, aimed to assess the potential of pupil dilation as an indicator of effort rather than task complexity. Their analysis revealed that heightened task demands in domains such as updating, switching, …


Considering A Unified Model Of Artificial Intelligence Enhanced Social Work: A Systematic Review, Michael Garkish, Lauri Goldkind Jan 2024

Considering A Unified Model Of Artificial Intelligence Enhanced Social Work: A Systematic Review, Michael Garkish, Lauri Goldkind

Social Service Faculty Publications

Social work, as a human rights–based profession, is globally recognized as a profession committed to enhancing human well-being and helping meet the basic needs of all people, with a particular focus on those who are marginalized vulner- able, oppressed, or living in poverty. Artificial intelligence (AI), a sub-discipline of computer science, focuses on develop- ing computers with decision-making capacity. The impacts of these two disciplines on each other and the ecosystems that social work is most concerned with have considerable unrealized potential. This systematic review aims to map the research landscape of social work AI scholarship. The authors analyzed the …


Innovation And Modernization In Irrigation And Drainage: A Guide To Why, What, And How, Christopher Ward, Charles M. Burt, Svetlana Valieva, Ahmed Shawky, David Casanova, David Meerbach Jan 2024

Innovation And Modernization In Irrigation And Drainage: A Guide To Why, What, And How, Christopher Ward, Charles M. Burt, Svetlana Valieva, Ahmed Shawky, David Casanova, David Meerbach

BioResource and Agricultural Engineering

Both irrigation and drainage (I&D) are vital to the proper development of crops. Irrigation is the application of water to plant roots to supply moisture needed for optimal plant growth. It complements water that is available to crops through precipitation and the moisture stored in the soil. Irrigation schemes have been used since times immemorial to enhance the availability of water at the crop root zone.


Numerical Analysis Of A Novel Elastohydrodynamic Seal For Supercritical Co2 Power Cycles With Experimental Verification, Ali Akbor Topu Jan 2024

Numerical Analysis Of A Novel Elastohydrodynamic Seal For Supercritical Co2 Power Cycles With Experimental Verification, Ali Akbor Topu

College of Graduate Studies: Theses & Dissertations

Supercritical carbon dioxide (sCO2) power cycles outperform conventional thermodynamic cycles regarding the efficiency and equipment footprint because of its unique property of maintaining the density of liquid in the gaseous phase at supercritical state (304.13 K and 7.37 MPa). It has robust use in concentrated solar power, fossil fuel power plants, geothermal electricity, nuclear power, and ship propulsion. To fully utilize sCO2 power cycles, technology readiness must be demonstrated at 10-60 MWe scale, with a working temperature and pressure of 350-700°C, and 10-35 MPa respectively. A crucial obstacle to the full realization of this technology is the absence …


Detecting Bearing Race Defects With Inductive Magnetic Reluctance Sensors And Artificial Neural Networks, Collin Daly Jan 2024

Detecting Bearing Race Defects With Inductive Magnetic Reluctance Sensors And Artificial Neural Networks, Collin Daly

College of Graduate Studies: Theses & Dissertations

This work proposes a method of detecting physical damage to bearing races in a rotational assembly by means of magnetic reluctance sensors generating a signal from a rotating gear-tooth wheel. A nominally sinusoidal signal is generated based on the rotation of a gearwheel with regularly spaced voids and lands. Detection is based on the time variance of the signal periodically in relation to the gearwheel and the bearing damage. The purpose of this work is to propose a process to detect and classify bearing race defects using existing sensors and neural networks for hazardous area equipment applications.


Functional Monitoring For Run-Time Assurance Of A Real-Time Cyber Physical System, Matthew W. Gelber Jan 2024

Functional Monitoring For Run-Time Assurance Of A Real-Time Cyber Physical System, Matthew W. Gelber

Theses and Dissertations

As cyber-physical systems (CPS) become more integrated into everyday life, the security of these systems must also be considered during their development due to their ever-increasing importance. With the growth of physical components in the system, more autonomous control requirements, and increased dependence on proper functionality, verifying system safety and correct operation becomes increasingly difficult. CPS have become more complex through the combination of additional hardware and the resulting interconnected software in many layers, each requiring unique security solutions. One example of such a safety-critical CPS embedded system is the Flight Control System (FCS) of an Unmanned Aerial System (UAS). …


Levofloxacin Incorporated Extracellular Matrix Nanoparticles For Pulmonary Cystic Fibrosis Infections, Raahi Patel Jan 2024

Levofloxacin Incorporated Extracellular Matrix Nanoparticles For Pulmonary Cystic Fibrosis Infections, Raahi Patel

Theses and Dissertations

Cystic fibrosis (CF) is a progressive genetic disorder that affects around 40,000 people in the United States. CF is characterized by a mutation in the CFTR protein that causes dysregulated ion transport across epithelial cells, producing viscous mucus in the lung that increases bacterial invasion, causing persistent infections and subsequent inflammation. Pseudomonas aeruginosa and Staphylococcus aureus are two of the most common infections in CF patients that are resistant to antibiotics. One antibiotic approved to treat these infections is levofloxacin (LVX) that functions to inhibit bacterial replication, but can be further developed into tailorable particles. Nanoparticles are an emerging inhaled …


The Effects Of Various Nanoplastics On The Inflammatory Response In Primary Alveolar Epithelial Cells, Eunice J. Pak Jan 2024

The Effects Of Various Nanoplastics On The Inflammatory Response In Primary Alveolar Epithelial Cells, Eunice J. Pak

Theses and Dissertations

As plastic pollution begins to multiply in the environment and the workplace, gradual degradation of these plastics creates an unseen threat to biological health: nanoplastics. These nanoplastics are common in day-to-day life, and have been found in various internal organs of the human body. The biological and health effects of these nanoplastics are still widely unknown, and only recently has research focused on the impacts of these particles on human health at the cellular level.

In this thesis, poly(methyl methacrylate) and three forms of polystyrene (carboxyl-modified, amine-modified, and neutral surface charge) have been tested on submerged primary C57BL/6 mouse alveolar …


The Effect Of 17Β Estradiol On Local Production Of Active Vitamin D3 Metabolites In Laryngeal Squamous Cell Carcinoma, Tillat Batool Jan 2024

The Effect Of 17Β Estradiol On Local Production Of Active Vitamin D3 Metabolites In Laryngeal Squamous Cell Carcinoma, Tillat Batool

Theses and Dissertations

Laryngeal squamous cell carcinoma (LSCC) has garnered attention as a sex-hormone-dependent cancer with notable responsiveness to 17β-estradiol (E2), in which it’s tumorigenesis can be mediated through estrogen receptors (ER). The ESR1 gene encodes for the classical full-length ERα66, as well as splice variants ERα36 and ERα46. Previous studies have shown that an active vitamin D3metabolite, 24R,25(OH)2D3. has pro-tumorigenic or anti-tumorigenic responses in LSCC cells with different ER profiles, and that the tumor cells have the capability of localized production of vitamin D metabolites at the cellular level when treated with 25(OH)D3-d6 …