Digital Commons Network^™

Computer Assisted Molecular Modeling Of Thymidine Nucleoside Analog Inhibitors Of Hiv-1 Reverse Transcriptase, Mark A. Fisher

Theses

An active analog approach to receptor mapping was used to identify the three dimensional structural characteristics associated with a series of thymidine nucleoside analog inhibitors of HIV-1 reverse transcriptase (RT) that may be essential for their activity. Atomic substitutions at the 5 and 3' positions of nucleoside analogs confer global structural and electrostatic changes that result in either increased or diminished inhibitory activity. From a structural perspective, the activity differences can be attributed to the presentation of select atoms in three dimensional motifs that are common to all active compounds and absent or distorted in inactive/poorly active compounds.

The identification …

The Development Of A Senior Unit Operations Laboratory On The Supercritical Extraction Of Solid Naphthalene With Supercritical Carbon Dioxide, Ronald G. Gabbard

Theses

A Senior level Undergraduate Unit Operations Laboratory experiment was developed for the extraction of Naphthalene with supercritical Carbon Dioxide. A Supercritical Extraction Screening System purchased from Autoclave Engineers of Erie, Pennsylvania was modified slightly for use as the laboratory equipment. The experiment consists of extracting solid naphthalene from a sand bed in a fixed bed extractor and determining the mass transfer coefficient for the unit.

The lab has been designed to allow the students to develop their own experimental plan without much direct input. The experimental outline provided for the students primarily focuses on information needed for safe and proper …

Acuta Enews October 1993, Vol. 22, No. 10

ACUTA Newsletters

In This Issue

E-mail

President's message

Data Comm Project at Delaware Tech

User Groups Meet at Conference

21st Century Technology

Staff Report

Bulletin - Fall, 1993, Civil Aviation Medical Association

Browse all Civil Aviation Medical Association Newsletters

A twelve page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.

Wright State University College Of Engineering And Computer Science Bits And Pcs Newsletter, Volume 9, Number 8, October 1993, College Of Engineering And Computer Science, Wright State University

BITs and PCs Newsletter

A ten page newsletter created by the Wright State University College of Engineering and Computer Science that addresses the current affairs of the college.

Santa Clara Magazine, Volume 36 Number 1, Fall 1993, Santa Clara University

Santa Clara Magazine

10 - DISCONNECTED A loss of continuity and connectedness could be the price we pay for this era of decentralized, customized technology. By Timothy J. Lukes

14 - STRETCHED TO THE LIMIT Private colleges scramble to control financial aid costs, and families struggle with too few aid dollars to go around. Here are the stories of four families who have worked in partnership with the University to make it through. By Elizabeth Fernandez '79, Overview by Elise Banducci '87

23 - THE MORAL LIFE In his recent encyclical, the pope speaks out on human nature, Christian boundaries, and universal truths. …

Bs News

Building Services Engineering

No abstract provided.

Survey Of The Impacts Of Environmental Regulations On State Highway Operations, Theodore Hopwood Ii, Christopher M. Oberst

Kentucky Transportation Center Research Report

In recent years, the transportation industry in Kentucky as represented by Kentuckians for Better Transportation (KBT) and the Kentucky Transportation Cabinet (KyTC), have expressed concern over the growing impact of environmental regulations upon transportation activities in the state. The imposition of environmental regulations has resulted in higher costs for new construction and maintenance on roads, project delays, scheduling and financing difficulties, and the creation of additional transportation agency bureaucracy to address environmental regulation mandates. In Kentucky, the impacts of those regulations have not been thoroughly assessed nor have the attendant costs been measured. Coinciding with that lack of information is …

State Management Systems Status, J. M. Yowell

Kentucky's Annual Forum on Transportation

No abstract provided.

Privatization Of Transportation Functions, Merl M. Hackbart

Kentucky's Annual Forum on Transportation

No abstract provided.

Partners In Intermodalism, Kirk Harralson

Kentucky's Annual Forum on Transportation

No abstract provided.

Kentucky Transportation Hall Of Fame [1993], Kentucky Transportation Center

Kentucky's Annual Forum on Transportation

No abstract provided.

Review Of Planning Distribution Model (Pdm) Status And Application Possibilities For The Egyptian Irigation System, Robert W. Hill, Richard C. Peralta, Gary P. Merkley

Civil and Environmental Engineering Faculty Publications

The comprehensive water management Planning Distribution Model, or PDM, was developed by the Biological and Irrigation Engineering Department, Utah State University (USU), under contract with the United States Bureau of Reclamation (USBR). Most of the work was carried out in the Planning Sector, Ministry of Public Works and Water Resources (MPWWR) , in Cairo, under the Planning Studies and Models Component of the USAID funded Irrigation Management Systems Project.

Book Review, Suzanne B. Watson

RISK: Health, Safety & Environment (1990-2002)

Review of the book: HELENA SZEJNWALD BROWN, ET AL., CORPORATE ENVIRONMENTALISM IN A GLOBAL ECONOMY: SOCIETAL VALUES IN INTERNATIONAL TECHNOLOGY TRANSFER. (Quorum Books 1993) [264 pp.] Acknowledgments, bibliography, figures, index, tables. LC 92- 19851; ISBN: 0-89930-802-3. [$49.95. P.O. Box 5007, Westport CT 06881.]

Vinyl Chloride Biodegradation With Methanotrophic Attached Films, Yarrow M. Nelson, William J. Jewell

Civil and Environmental Engineering

Methanotrophic degradation of vinyl chloride (VC) is investigated using a laboratory-scale methanotrophic attached-film expanded-bed (MAFEB) bioreactor. This study provides a basis for applying a microbial cometabolizing reaction to practical treatment of toxic chlorinated compounds. The MAFEB reactor was operated at 20°C with influent VC concentrations ranging from 1,800 to 9,600 µg/L and bed hydraulic retention times ranging from 3.7 to 7.6 h. VC effluent concentrations during steady continuous operation ranged from 3 to 140 µg/L, with most values less than 26 µg/L, resulting in removal efficiencies of 96.3% to 99.8%. The maximum continuous-flow VC degradation rate observed at 20°C was …

Evaluation Of The Lexington-Fayette County Safety Belt Ordinance, Kenneth R. Agent

Kentucky Transportation Center Research Report

A mandatory safety belt ordinance was enacted in Fayette County with an effective date of July 1, 1990. One objective of this study was to conduct usage surveys after the ordinance had been in effect for approximately three years. This would allow comparisons to be made of safety belt usage before and immediately after the effective date of the ordinance to that found a substantial time period after enactment of the ordinance. A second objective of the study was to compere accident data before and after the ordinance became effective. The would allow an analysis of the effect the ordinance …

Research And Development Project Selection Tools: Probing Wright Laboratory's Project Selection Methods And Decision Criteria Using The Lateral Airfoil Concept, James E. Barger

Theses and Dissertations

This research accomplished three major tasks. First it examined familiarity and usage rates for fifteen published R&D project selection methods in the context of a larger general issue, the Air Force's ability to develop and exploit technology. Wright Laboratory served as the focus for the research effort and displayed a greater tendency to use formal methods in 1993 than was shown in prior research. The laboratory's overall preference for simpler models like Checklist, Scoring, and Sorting led to a recommendation that authors familiar with the other techniques communicate them in engineering and management vernacular. Secondly, the study introduced a technological …

Development Of An Effectiveness Model Or Metric For The Air Force Environmental Compliance Assessment And Management Program (Ecamp), Craig B. Dezell

Theses and Dissertations

The Department of Defense (DoD) and the Air Force (AF) are committed to being national leaders in protecting and enhancing the environment and achieving environmental compliance. This commitment is exemplified by the Air Force Chief of Staff's goal of no notices of violation (NOVs). However, the number of AF NOVs from 1990-1992 rose from 103 to 178 an increase of 73 percent. A July 1992 AF Inspector General Report also concluded that Environmental Compliance Assessment and Management Program (ECAMP) findings were not being effectively utilized by the Major Commands (MAJCOM). To aid AF leaders in solving these problems, and protecting …

Development Of A Multicriteria Decision Model For Prioritizing Air Force Environmental Restoration Program Projects, Thomas E. Ellingson, T. G. Gallogly

Theses and Dissertations

Cleaning up hazardous and toxic wastes left from past activities has become one of the major goals of the Department of Defense. Within the Air Force, individual major commands (MAJCOMs) annually review numerous projects submitted under the Defense Environmental Restoration Program (DERP) and forward these projects to HQ USAF/CEVR for funding. Until recently, adequate resources have been available to fully fund all projects. However, within the last two years, funding shortfalls have been experienced, and projects have received only partial funding. The Air Force needs a decision support system that will assist in determining funding priorities for these projects. This …

A Strategy For Combining The Pollution Prevention Opportunity Assessment With The Environmental Compliance Assessment And Management Program, Stacy E. Gent

Theses and Dissertations

This research develops a method to allow an installation environmental function to satisfy the assessment requirements of both the Air Force Pollution Prevention and the Environmental Compliance Assessment and Management Program with the implementation of one assessment process. The model developed is designed to achieve the goals of both programs while increasing the efficiency of implementation. The resulting assessment model formulated within this research is applied on a theoretical level to yield preliminary results. These results indicate that the combination of the Pollution Prevention Opportunity Assessment and the environmental compliance assessment required by the Environmental Compliance Assessment and Management Program …

Analytical Modeling Of Aquifer Decontamination By Pulsed Pumping When Contaminant Transport Is Affected By Rate-Limited Sorption And Desorption, Thomas A. Adams, Robert C. Viramontes

Theses and Dissertations

This research explores radially convergent contaminated transport in an aquifer towards an extraction well. This thesis presents the equations governing the transport of a contaminant during aquifer remediation by pulsed pumping. Contaminant transport is assumed to be affected by radial advection, dispersion, and sorption/desorption. Sorption is assumed to be either equilibrium or rate-limited, with the rate-limitation described by either a first-order law, or by Fickian diffusion of contaminant through layered, cylindrical, or spherical immobile water regions. The equations are derived using an arbitrary initial distribution of contaminant in both the mobile and immobile regions, and they are analytically solved in …

Application Of The Simplified Dow Chemical Company Relative Ranking Hazard Assessment Method For Air Combat Command Bases, Raymond A. Sable

Theses and Dissertations

This study investigates the possibility of determining the hazard potential of chemicals on Air Force bases using a relative ranking hazard assessment method. Hazard assessment includes identification of hazards and evaluation of the hazards. Title III of the Superfund Amendments and Reauthorization Act of 1986 requires hazard assessments by all facilities with extremely hazardous substances to prepare release prevention plans. The purpose of the hazard assessments is to provide information to improve the spill prevention, control and countermeasures plans and to identify the substances with the highest hazard potential. Using the results from the hazard assessments, bases cam prepare plans …

A Parametric Regression Of The Cost Of Base Realignment Action (Cobra) Model, Douglas D. Hardman, Michael S. Nelson

Theses and Dissertations

This study develops a parametric model that is capable of generating accurate estimates of the costs to close Air Force installations. The new model is based upon, but much simpler to use than, the Cost of Base Realignment Action (COBRA) model. COBRA is an economic cost analysis model that requires a minimum of 250 inputs and as many as 700 inputs. The new parametric model requires just 10 input variables and was developed using least squares multiple regression. Comparison of the new parametric model to COBRA indicates that it captures 91 percent of the variance in cost estimates generated by …

An Exploratory Survey Of Methods Used To Develop Measures Of Performance, Kenneth L. Hamner, Charles A. Lafleur

Theses and Dissertations

Nonmanufacturing organizations are being challenged to provide high- quality products and services to their customers, with an emphasis on continuous process improvement. Measures of performance, referred to as metrics, can be used to foster process improvement. The application of performance measurement to nonmanufacturing processes can be very difficult. This research explored methods used to develop metrics in nonmanufacturing Organizations. Several methods were formally defined in the literature, and the researchers used a two- step screening process to determine the OMB Generic Method was most likely to produce high-quality metrics. The OMB Generic Method was then used to develop metrics. A …

Evaluation Of The Total Petroleum Hydrocarbon Standard For Cleanup Of Petroleum Contaminated Sites, Rick A. Blaisdell, Mark E. Smallwood

Theses and Dissertations

This study evaluated the TPH (total petroleum hydrocarbon) cleanup standard for petroleum contaminated soils (PCS). A survey of 13 state regulators was performed to characterize current standards and regulatory viewpoints on the use of a TPH versus a BTEX cleanup standard. The regulatory community considers the BTEX constituents the greatest threat to groundwater, yet expressed concern that the use of a compound specific standard, without an accompanying analysis for TPH, might result in residual soil contamination that may present risk. This study also evaluated the ratio of BTEX TPH in soil over time. Based on JP-4 contaminated site soil data, …

A Refinement Of Risk Analysis Procedures For Trichloroethylene Through The Use Of Monte Carlo Method In Conjunction With Physiologically Based Pharmacokinetic Modeling, William J. Cronin Iv, Eric J. Oswald

Theses and Dissertations

This study refines risk analysis procedures for trichloroethylene (TCE) using a physiologically based pharmacokinetic (PBPK) model in conjunction with the Monte Carlo method. The Monte Carlo method is used to generate random sets of model parameters, based on the mean, variance, and distribution types. The procedure generates a range of exposure values for human excess lifetime cancer risk of lxl0 (exp-6), based on the upper and lower bounds and the mean of a 95% confidence interval. Risk ranges were produced for both ingestion and inhalation exposures. Results are presented in a graphical format to reduce reliance on qualitative discussions of …

A Decision Support Model Using Life Cycle Cost (Lcc) Analysis To Select Cost-Effective Alternatives For Hazardous Materials, Blaine F. Burley, Kirk A. Phillips

Theses and Dissertations

This research focuses on the development of a decision support model to select cost-effective alternatives for hazardous materials using life cycle cost (LCC) analysis. The model provides an effective decision-making tool to evaluate the economic feasibility of using alternatives for hazardous materials. Given a specific operation, the users of this model can enter site-specific cost data to determine the total LCCs of using baseline hazardous materials (i.e., hazardous materials currently being used in an operation), as well as the total LCCs of using various alternatives. This thesis postulates that the material having the lowest total LCC is considered to be …

A Predictive Model For The Determination Of The Economic Feasibility Of Construction And Demolition Waste Recycling In The Air Force, Byron L. Dixon

Theses and Dissertations

This study created a model to be used at a CONUS Air Force base to determine the economic feasibility of Construction and Demolition (C&D) waste recycling. Three areas investigated to develop this model: the methods to determine amounts and types of C&D waste generated at a specific location, the markets for recycled C&D wastes, and the recycling methods currently available. From this data, gathered through records searches and interviews, a procedure was developed to perform cost/benefit analyses on the available recycling options. A model was then created based on these calculations which can arm a manager with information to either …

Bs News

Building Services Engineering

No abstract provided.

Investigation Of The Sensitivity, Selectivity, And Reversibility Of The Chemically-Sensitive Field-Effect Transistor (Chemfet) To Detect Nitrogen Dioxide, Dimethyl Methylphosphonate, And Boron Trifluoride, Neal T. Hauschild

Theses and Dissertations

This study investigated the sensitivity, selectivity, and reversibility of a chemically-sensitive field-effect transistor (CHEMFET) gas microsensor. Various physical operating parameters were tested to determine which produced the most significant sensitivity, selectivity, and reversibility which were computed from response changes generated from electrical conductivity modulations when exposed to challenge gases. The variable operating parameters included: thinfilm material, film thickness, challenge gas specie, challenge gas concentration, and operating temperature. Copper phthalocyanine and lead phthalocyanine were used as thin films to detect the following challenge gases: nitrogen dioxide, dimethyl methylphosphonate, boron trifluoride, methanol, carbon monoxide, vinyl chloride, and trichloroethylene. Tests revealed that copper …