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Model Performance For Predicting Trends And Analyzing The Impacts Of Sea Surface Temperature Changes In The Gulf Of Thailand, Tanatpong Udomchaipitak, Nathaphon Boonnam Jan 2025

Model Performance For Predicting Trends And Analyzing The Impacts Of Sea Surface Temperature Changes In The Gulf Of Thailand, Tanatpong Udomchaipitak, Nathaphon Boonnam

Journal of Marine Science and Technology–Taiwan

This study focuses on assessing and improving the predictive performance of sea surface temperature (SST) in the Gulf of Thailand under unique environmental challenges. Data from the Hybrid Coordinate Ocean Model (HYCOM) were utilized, covering the period from July 1994 to June 2024 at depths ranging from 0 to 30 meters. After cleaning the data using the Interquartile Range (IQR) method, the processed dataset was tested using four models: Recurrent Neural Network (RNN) architectures, including Long Short-Term Memory (LSTM) and Gated Recurrent Unit (GRU), as well as Convolutional Neural Networks (CNNs). Model performance was enhanced by tuning the parameters over …


Multimodal Imaging Of Protein-Based Biomaterials For Delivering Chemo-Agent Cargo For Glioblastoma Treatment In A Murine Model, Orin Mishkit Jan 2025

Multimodal Imaging Of Protein-Based Biomaterials For Delivering Chemo-Agent Cargo For Glioblastoma Treatment In A Murine Model, Orin Mishkit

Dissertations and Theses

Protein-based self-assembling biomaterials, known as Thermo-Responsive Assembled Proteins (TRAP), present meaningful potential as drug delivery carriers. These materials enable the controlled, slow release of poorly soluble chemotherapeutic agents, such as doxorubicin (Dox), while potentially reducing systemic off-target effects. In collaboration with multiple NYU labs, this study evaluated the efficacy of two TRAP variants—TRAP and F-TRAP—as drug delivery carriers in a xenograft mouse model of glioblastoma multiforme (GBM).

The primary objective was to compare the effectiveness of TRAP-loaded Dox (TRAP-DOX) to free Dox in achieving tumor extravasation and accumulation, facilitating sustained drug release. We hypothesized that the leaky vasculature of GBM …


Adaptation Of The Biodent For Spherical Microindentation To Determine Elastic Modulus In Small Rodent Bones, Mixame E. Jerome Jan 2025

Adaptation Of The Biodent For Spherical Microindentation To Determine Elastic Modulus In Small Rodent Bones, Mixame E. Jerome

Dissertations and Theses

Mechanical and material properties of bone are essential for understanding both normal skeletal function and the progression of bone-related diseases. Microindentation has become a widely used method for evaluating tissue mechanical properties of bone, as it samples the contributions of microarchitecture and composition. Microindentation using a standard pointed tip inherently introduces both elastic and plastic deformation into the material. In contrast, indentation with a spherical tip can be operated entirely in the elastic range, providing for a non-damaging test that has significant advantages over sharp indentation techniques. Moreover, a key advantage of using spherical indentation lies in its operation under …


Explorations Of Dna-Single-Walled Carbon Nanotube Interactions To Develop Multiplexed Molecularly Specific Biosensors For Inflammation, Amelia K. Ryan Jan 2025

Explorations Of Dna-Single-Walled Carbon Nanotube Interactions To Develop Multiplexed Molecularly Specific Biosensors For Inflammation, Amelia K. Ryan

Dissertations and Theses

Inflammatory cytokines such as interleukin-6 (IL-6) and interleukin-12 (IL-12) are central regulators of immune signaling and key biomarkers of disease, yet existing assays for their detection remain slow, invasive, and lack multiplexing ability. This dissertation advances the development of single-walled carbon nanotube (SWCNT) optical nanosensors capable of real-time, multiplexed, and molecularly specific cytokine detection through innovative use of single-stranded DNA (ssDNA) interfaces.

First, an IL-6-specific DNA aptamer was employed as both a dispersing agent and recognition probe for SWCNT fluorescence sensing. Sequence modifications, including anchor domains, truncations, and thermally induced refolding, were systematically tested to optimize sensitivity and selectivity. The …


Wearable Disposable Elecetrotherapy, Mohamad Fallahrad Jan 2025

Wearable Disposable Elecetrotherapy, Mohamad Fallahrad

Dissertations and Theses

Non-invasive electrotherapies offer promising treatments for a wide range of conditions such as pain, headaches, depression, addiction, cognitive decline, wound healing, and drug delivery. However, patient compliance remains low due to the high initial cost, cumbersomeness and inconvenience of existing technology compared to pharmaceuticals. Current electrotherapy devices are often bulky and require users to connect disposable electrodes, initiate programs, and manage charging cycles, which hinders widespread adoption.

We address these challenges by designing and validating a novel electrotherapy platform that is single-use, disposable, low-cost, and wearable. Activated automatically upon skin contact, the device delivers a preset dose of controlled electrical …


Characterization Of The Intrinsic Neural Timescale Indices As A Reliable Fingerprint Of Brain Dynamics, Helya Honarpisheh Jan 2025

Characterization Of The Intrinsic Neural Timescale Indices As A Reliable Fingerprint Of Brain Dynamics, Helya Honarpisheh

Dissertations and Theses

Intrinsic neural timescales (INTs) characterize the persistence of neural activity over time and offer insight into the brain’s temporal hierarchy. This thesis evaluates and compares six autocorrelation-based INT metrics—AR(1) Coefficient (Autoregressive Coefficient at 1), First Zero Lag, Lag at ACF = 1/e, Sum of Positive ACFs, ACF at Half Lag, Exponential Decay Constant (τ)— using resting-state fMRI data from 400 cortical regions across a large, lifespan sample (ages 6– 85) from the NKI-Rockland dataset. A discriminability analysis revealed that the AR(1) coefficient provided the highest test-retest reliability and individual specificity across repeated scans, establishing it as the most reliable INT …


Data Driven Bridge Deck Deterioration Modeling And Maintenance Intervention Scheduling, Deepak Kumar Jan 2025

Data Driven Bridge Deck Deterioration Modeling And Maintenance Intervention Scheduling, Deepak Kumar

Dissertations and Theses

Majority of over 617,000 bridges across the United States are significantly impacted by environmental factors, aging materials, and heavy traffic loads. According to the 2021 Infrastructure Report, nearly 231,000 bridges require repair or preservation work, with 46,154 (7.5%) being classified as structurally deficient, thereby posing risks for mor than 178 million daily trips across these bridges. Despite recent improvements, 42% of U.S. bridges are at least 50 years old, underscoring an urgent need for increased investment to meet repair demands. The nation’s backlog of bridge repairs is estimated at $125 billion, with a 58% increase in annual spending required to …


Generation And Characterization Of Human Blood-Brain Barrier Models For Investigating Neuropsychiatric Disorders And Tumor Metastasis, Yunfei Li Jan 2025

Generation And Characterization Of Human Blood-Brain Barrier Models For Investigating Neuropsychiatric Disorders And Tumor Metastasis, Yunfei Li

Dissertations and Theses

The blood–brain barrier (BBB) is important in the normal function of the central nervous system (CNS). An altered BBB has been described in various neuropsychiatric disorders. The brain-specific microvascular endothelial cell (BMEC) is an essential structural component of the BBB. To test if integrity of the BBB formed by BMECs is compromised in 22q11.2 deletion syndrome (also called DiGeorge syndrome), which is one of the validated genetic risk factors for schizophrenia, a 2D iBBB (induced BBB) on a Transwell filter was generated from human microvascular endothelial cells (HBMECs) derived from the induced pluripotent stem cells (iPSCs) out of patients with …


Deep Learning Architectures For Improving Weather Research And Forecasting (Wrf) Precipitation Estimates And Landslide Susceptibility Mapping: A Case Study Of Puerto Rico, Said A. Mejia Manrique Jan 2025

Deep Learning Architectures For Improving Weather Research And Forecasting (Wrf) Precipitation Estimates And Landslide Susceptibility Mapping: A Case Study Of Puerto Rico, Said A. Mejia Manrique

Dissertations and Theses

Precipitation is a critical factor in the Earth’s hydrological cycle and has a profound impact on various environmental and socioeconomic systems, including management of water resources, flood forecasting, and the evaluation of natural hazards, particularly those associated with rainfall-induced landslides. For the latter, obtaining precise precipitation estimates is essential, as intense rainfall events can trigger landslides that pose significant risks to human life, infrastructure, and ecosystems, particularly in mountainous regions. Puerto Rico (PR), with its mountainous terrain, tropical climate, and vulnerability to hurricanes, provides a unique environment for studying precipitation patterns and the need for accurate rainfall estimates. The complex …


Command & Data Handling, Firmware & Software, Utah State University Space Dynamics Laboratory Jan 2025

Command & Data Handling, Firmware & Software, Utah State University Space Dynamics Laboratory

Space Dynamics Laboratory Publications

UNP Presentation on Command & Data Handling, Firmware & Software


Celis: Compact Eyesafe Lidar System, A Portable 1.5 Μm Elastic Lidar System For Rapid Aerosol Concentration Measurement: Part 2, Retrieval Of Particulate Matter Concentration, Kori D. Moore, Alan W. Bird, Michael D. Wojcik, Robert Lemon, Jerry L. Hatfield Jan 2025

Celis: Compact Eyesafe Lidar System, A Portable 1.5 Μm Elastic Lidar System For Rapid Aerosol Concentration Measurement: Part 2, Retrieval Of Particulate Matter Concentration, Kori D. Moore, Alan W. Bird, Michael D. Wojcik, Robert Lemon, Jerry L. Hatfield

Space Dynamics Laboratory Publications

SDL Poster on the CELiS Compact Eyesafe Lidar System


High-Performance Small Satellites For Demanding Missions, Lance Fife Jan 2025

High-Performance Small Satellites For Demanding Missions, Lance Fife

Space Dynamics Laboratory Publications

SDL Presentation on High Performance Small Satellites


Space 101 (Eps Electrical Power System), Shane Topham Jan 2025

Space 101 (Eps Electrical Power System), Shane Topham

Space Dynamics Laboratory Publications

Introduction

  • Power Storage (Battery)
  • Power Generation (Solar Arrays)
  • Power Regulation & Distribution
  • Other EPS functions


A Review Of Infrared Thermography Applications For Civil Infrastructure, Prabal Shrestha, Onur Avci, Sahabeddin Rifai, Feras Abla, Michael Seek, Karl Barth, Udaya Halabe Jan 2025

A Review Of Infrared Thermography Applications For Civil Infrastructure, Prabal Shrestha, Onur Avci, Sahabeddin Rifai, Feras Abla, Michael Seek, Karl Barth, Udaya Halabe

Engineering Technology Faculty Publications

Civil infrastructure is continuously subject to aging and deterioration due to multiple factors, which lead to a decline in performance and impact structural health. Accumulated damage on structures increases operational costs and poses significant risks to public safety. Effective maintenance, repair, and rehabilitation strategies are needed to ensure civil infrastructure’s overall safety and reliability. Non-Destructive Evaluation (NDE) methods are utilized to assess latent damage and provide decision-makers with real-time information for mitigating hazards. Within the last decade, there has been a significant increase in the research and development of innovative NDE techniques to improve data processing and promote efficient and …


Improving Visual Inspection Performance During Pre-Flight Visual Inspections By Aircraft Maintenance Technicians., Patrick Codd Jan 2025

Improving Visual Inspection Performance During Pre-Flight Visual Inspections By Aircraft Maintenance Technicians., Patrick Codd

Doctoral

Visual inspection is a critical task in aircraft maintenance and is the predominant inspection technique used in the global aviation sector. For safety reasons, visual inspections by Aircraft Maintenance Technicians are routinely conducted on a daily basis during pre-flight inspections. Its significance becomes evident when considering the potential consequences of Aircraft Maintenance Technicians not seeing observable defects during visual inspections. For example, an aircraft crash landing in 1989 resulted in 111 fatalities and was attributed to a visual inspection failure. The industrial quality control literature also illustrates the varying accuracy for the observation of defects and hazards, underscoring the inherent …


Assessment And Optimization Of Electric Vehicles Charging Infrastructure: Addressing Accessibility Disparities In Urban And Rural Areas, Dennis B. Bwire Jan 2025

Assessment And Optimization Of Electric Vehicles Charging Infrastructure: Addressing Accessibility Disparities In Urban And Rural Areas, Dennis B. Bwire

UNF Graduate Theses and Dissertations

The widespread adoption of electric vehicles (EVs) is essential for advancing sustainable transportation systems; however, disparities in the spatial distribution of electric vehicle charging stations (EVCS) present significant challenges for equitable access. This thesis investigates both the inequities in EVCS accessibility and offers a data driven approach for optimizing the siting of future charging infrastructure.

The first part of the study investigates the accessibility of EVCS in rural and urban areas, focusing on how socio-demographic factors influence accessibility metrics. Using geographic information systems (GIS), network analysis, and binary logistic regression, spatial data on EVCS locations and socio-demographic attributes such as …


Computational Pangenomics And Machine Learning For Genotype-Phenotype Analysis, Tejaswi Vemuri Jan 2025

Computational Pangenomics And Machine Learning For Genotype-Phenotype Analysis, Tejaswi Vemuri

UNF Graduate Theses and Dissertations

Phenotypes are the observable characteristics of an individual organism. Predicting quantitative phenotypes from genomic variation remains challenging when causal signals span both local motifs and distal regulatory contexts. Building on Frequented Regions (FRs)—subsequences conserved across genomes and extracted from a pangenome graph generated from a large collection of closely related species—we compare several modeling strategies across 35 Saccharomyces cerevisiae growth phenotypes: Random Forest (RF) on FR counts (called RFCounts), RF on FR sequences, 1D convolutional neural networks (CNN) on FR sequences, Long Short-Term Memory (LSTM) networks on FR sequences, a Genomewide Association Study (GWAS) baseline, and a sequence-based transformer model, …


Deep Learning Approaches For Predicting Strain Energy In Heterogeneous Materials, Junesh Gautam Jan 2025

Deep Learning Approaches For Predicting Strain Energy In Heterogeneous Materials, Junesh Gautam

Electronic Theses and Dissertations

Finite Element Analysis (FEA) faces computational challenges when analyzing nonlinear and heterogeneous materials. Utilizing the Mechanical MNIST dataset, comprising 60,000 simulated samples of 28x28 pixel domains under large deformation, the study evaluates classical regression methods (Linear Regression, Random Forest, Gradient Boosting) and advanced deep learning architectures (Convolutional Neural Networks (CNN) and Residual Networks (ResNet)). CNN models achieved superior performance, with a Mean Squared Error (MSE) of 4.21 and an R2 value of approximately 0.982, outperforming classical regression models and slightly surpassing ResNet architectures. These deep learning methods automatically learn spatial relationships from pixel-based representations, eliminating the need for manual feature …


Leveraging Deep Learning For The Automated Detection Of Hemophilic Arthropathy In Knee Radiographs, En-Wei Lin, Edzer Wu, Ming-Ching Shen, Shao-Li Han Jan 2025

Leveraging Deep Learning For The Automated Detection Of Hemophilic Arthropathy In Knee Radiographs, En-Wei Lin, Edzer Wu, Ming-Ching Shen, Shao-Li Han

Rehabilitation Practice and Science

Background/Purpose:

Hemophilic arthropathy (HA) is a progressive joint disease caused by recurrent hemarthroses in patients with hemophilia. Early radiographic identification of HA is critical for timely intervention and long-term joint preservation. This study aimed to develop and evaluate deep learning models for automated detection of HA in knee radiographs.

Methods:

A retrospective dataset of 849 knee radiographs (AP and lateral views) was used to train three convolutional neural networks: ResNet-34, DenseNet-121, and EfficientNet-B0. Model performance was assessed using standard classification metrics, including accuracy, precision, recall, F1-score, and AUC. Interpretability was evaluated using Grad-CAM heatmaps.

Results:

DenseNet-121 achieved balanced performance on …


Cultivating Plain Language Skills For Engineering Students, Catherine Wong, Cynthia Carlson Jan 2025

Cultivating Plain Language Skills For Engineering Students, Catherine Wong, Cynthia Carlson

Faculty Publications

While engineers are learning the vocabulary of the profession, understandably, they want to practice, and perhaps show their professors that they are proficient. This leads to student writing that is overly complicated and full of jargon. This is not the type of document that would be clear to the public, or even to a professional outside of the narrowly focused field of the particular engineer. After graduation, engineers’ writing becomes exponentially more important. Often approval of projects relies on residents’ or clients’ understanding of engineers’ work. For example, an engineering firm completing an investigation of an important health concern such …


An Operational Field Study: A Comparison Of Piloting Uncrewed Underwater Vehicles And Uncrewed Aircraft Systems, David Thirtyacre, Joseph Cerreta, Pete Miller, Kimberly Luthi, Jolee Thirtyacre Jan 2025

An Operational Field Study: A Comparison Of Piloting Uncrewed Underwater Vehicles And Uncrewed Aircraft Systems, David Thirtyacre, Joseph Cerreta, Pete Miller, Kimberly Luthi, Jolee Thirtyacre

Publications

and operations, the ability to cross-train personnel in both Uncrewed Underwater Vehicles and Small Uncrewed Aircraft System operations has become a focal point for efficiency and workforce optimization. This study presents a comparative analysis of the operational and human factor considerations involved in piloting mini UUV and sUASs, highlighting the key similarities and differences in control methods, environmental influences, navigation, emergency procedures, and situational awareness. A qualitative experimental field study was conducted between July 2024 and October 2024, involving real-world deployments of both systems in maritime and aerial environments. Findings indicated that while UUV and sUAS operators relied on remote …


Factors Contributing To Fatalities In Helicopter Emergency Medical Service Accidents, Jenna Korentsides, Joseph R. Keebler, Mihhail Berezovski, Alex Chaparro Jan 2025

Factors Contributing To Fatalities In Helicopter Emergency Medical Service Accidents, Jenna Korentsides, Joseph R. Keebler, Mihhail Berezovski, Alex Chaparro

Publications

INTRODUCTION: T his study aimed to update and reinforce previous research on helicopter emergency medical service accidents in the United States. By investigating predictors of fatalities after helicopter emergency medical service crashes through the application of machine learning techniques, we updated existing data sets and sought to uncover patterns that traditional analysis might not reveal.

METHODS: Using the National Transportation Safety Board database, the authors analyzed a dataset of 267 helicopter emergency medical service accidents between 1991–2022. We first calculated fatalities odds ratios for each condition. We then plotted geospatial locations of all reported accidents. Finally, we used XGBoost regression …


The Optimization And Manufacturing Scale-Up Of Polymeric Membranes Using Eco-Friendly Solvents, David Lu Jan 2025

The Optimization And Manufacturing Scale-Up Of Polymeric Membranes Using Eco-Friendly Solvents, David Lu

Theses and Dissertations--Chemical and Materials Engineering

Polymeric membranes have become a prominent technology applied in water filtration due to the lower cost, energy input, and simpler manufacturing process relative to other separation technologies. However, the environmental impact of polymeric membrane fabrication remains a hindrance due to the use of hazardous solvents derived from fossil fuels (e.g., DMAc, NMP, DMF) that pose a risk to the environment and human health. Whereas recent studies have demonstrated the proof-of-concept of polymeric membrane derived from eco-friendly solvents, the next steps of optimizing and upscaling the production of these membranes remains understudied and a gap between lab-scale studies and the path …


Combinatorial Thin Film Approach To Accelerate Materials Discovery: Development Of Nanoporous And Bulk Multi-Principal Element Alloys, Tibra Das Gupta Jan 2025

Combinatorial Thin Film Approach To Accelerate Materials Discovery: Development Of Nanoporous And Bulk Multi-Principal Element Alloys, Tibra Das Gupta

Theses and Dissertations--Chemical and Materials Engineering

Multi-principal element alloys (MPEAs) have garnered significant attention in materials science due to their potential for exhibiting a combination of desirable properties stemming from their unique configurational entropy. While early research focused on equiatomic compositions, recent studies have indicated that non-equiatomic MPEAs may offer superior mechanical performance. However, the identification of optimal non-equiatomic compositions remains challenging due to the vast compositional space and the reliance on time-consuming and computationally expensive methods. This dissertation presents a combinatorial thin film approach as a rapid and efficient strategy for discovering two types of materials: nanoporous and bulk MPEAs.

The first study explores the …


Geospatial Analysis For Urban Resilience: Green Space, Flood Susceptibility, And Wetland Restoration Potential, Jessica Lareaux Jan 2025

Geospatial Analysis For Urban Resilience: Green Space, Flood Susceptibility, And Wetland Restoration Potential, Jessica Lareaux

Dissertations, Master's Theses and Master's Reports

Through the integration of high-resolution geospatial data, hydrologic modeling, and spatial statistics, this research addresses three interrelated topics that are critical to sustainable, equitable, and climate-resilient urban planning. The overall objective of this dissertation is to provide data-driven and machine learning-based geospatial analysis frameworks that enhance our understanding of environmental inequities, flood exposure, and the potential for wetland restoration, with a focus on urban contexts. The study presented in Chapter Two examines the distribution and accessibility of urban green spaces in Detroit, Michigan, using high-resolution geospatial data and geospatial analysis methods, including geographically weighted regression (GWR) and network-based analyses. This …


Batteryless Nfc-Enabled Wireless Sensor Node: Design, Optimization, And Implementation, Rishin Patra Jan 2025

Batteryless Nfc-Enabled Wireless Sensor Node: Design, Optimization, And Implementation, Rishin Patra

Dissertations, Master's Theses and Master's Reports

This thesis presents the design, construction, and testing of a batteryless Near-field communication (NFC) powered wireless sensor node intended for maintenance free, short range Internet of Things (IoT) applications. The work focuses on harvesting energy from a 13.56 MHz NFC field to power a very low-power sensing platform capa- ble of measuring temperature, pressure, and humidity without the use of batteries or wired power. The motivation behind this approach is the growing need for reliable, sustainable, and low-maintenance sensing systems that can operate in environments where battery replacement is impractical, undesirable, or environmentally costly. The prototype is built around a …


Bayesian Networks For Safety-Critical Systems, Joseph Mietkiewicz Jan 2025

Bayesian Networks For Safety-Critical Systems, Joseph Mietkiewicz

Theses

This thesis addresses a operational challenge in modern industrial operations: the increasing complexity of systems and the consequent cognitive burden on operators. As industrial technologies advance, the human-computer interface has become the primary conduit for information flow, playing a pivotal role in operational decision-making. However, the proliferation of data often leads to information overload, potentially compromising rather than enhancing operator performance. This research explores an approach to this pressing issue through the application of Bayesian networks as decision support systems in safety- critical scenarios. Our study employs a multi-faceted approach, combining theoretical modeling with empirical testing. Through collaboration with industry …


Development Of A Mediation Model Of Pain Cognition In Adult Patients With Sickle Cell Disease, Daniel M. Sop Jan 2025

Development Of A Mediation Model Of Pain Cognition In Adult Patients With Sickle Cell Disease, Daniel M. Sop

Theses and Dissertations

Pain is a hallmark of Sickle Cell Disease (SCD), a genetic hemoglobinopathy characterized by chronic hemolytic anemia, vaso-occlusion, and organ damage. While acute vaso-occlusive crises (VOC) have been extensively studied, the mechanisms underlying chronic pain and its interplay with brain function remain unclear. This dissertation investigates the relationships between cerebral blood flow (CBF), fluid cognition, and pain sensitivity in adults with SCD, utilizing advanced imaging techniques and validated assessment tools.

Arterial spin labeling (ASL) and functional magnetic resonance imaging (fMRI) were employed to measure CBF and brain activity, respectively. Pain sensitivity was assessed using the Pain Sensitivity Questionnaire (PSQ), and …


Strength Imbalances And Shoulder Pain In Manual Wheelchair Users Stratified By Age Of Spinal Cord Injury/Disorder (Sci/D) Onset, Ashlyn M. Jones Jan 2025

Strength Imbalances And Shoulder Pain In Manual Wheelchair Users Stratified By Age Of Spinal Cord Injury/Disorder (Sci/D) Onset, Ashlyn M. Jones

Theses and Dissertations

Introduction The majority of manual wheelchair users (MWUs) with spinal cord injury or disorder (SCI/D) develop shoulder pain. In adults with SCI/D, there is evidence that upper limb strength imbalances are associated with shoulder pain. However, strength imbalances may indicate protective compensatory strategies, and other factors may be important contributors to pain. Currently, personalized prevention and management of pain is limited, little is known about joint strength imbalances and pain in children who use manual wheelchairs, and the effect of the age of SCI/D onset is poorly understood. The purpose of this study was to assess the effect of age …


Hafnium Oxide-Based Nanoheterostructures For Catalytic Radiosensitization And Enhanced X-Ray Radiotherapy, Marlen Dariela Calix Quezada Jan 2025

Hafnium Oxide-Based Nanoheterostructures For Catalytic Radiosensitization And Enhanced X-Ray Radiotherapy, Marlen Dariela Calix Quezada

Theses and Dissertations

Orthovoltage X-ray beams are attractive for surface and intra-operative radiotherapy. Yet, their clinical utility is constrained by rapid attenuation and the limited dose that can be delivered without harming healthy tissue. High-Z hafnium oxide (HfO2) nanoparticles can boost local energy deposition through the photoelectric effect, while catalytic surface defects accelerate water radiolysis. Harnessing both mechanisms in a single nano-heterostructure could enable potent radiosensitization at diagnostic-range energies.

This thesis develops and evaluates HfO2-based nanoheterostructures, both bare and Au-decorated, as catalytic radiosensitizers.

Two types of HfO2 were evaluated, one was synthesized following a specific route and the …