Digital Commons Network^™

Vaccine Technology Ii: Conference Program, Barry C. Buckland, John G. Auniņš, Paula Marques Alves, Kathrin U. Jansen

Vaccine Technology II

No abstract provided.

Emerging Diseases, Zoonoses And Vaccines To Control Them, Paul-Pierre Pastoret

Vaccine Technology II

No abstract provided.

Vaccine Technology Ii: Abstracts Of Oral Presentations, The Editors

Vaccine Technology II

No abstract provided.

Challenges And Solutions For The Next Generation Of Vaccines: Development Of Cell Culture-Based Live Attenuated Influenza Vaccine, Jonathan Liu, Luis Maranga, Sachin Mani, Richard Schwartz

Vaccine Technology II

No abstract provided.

Developing Vaccines For Neglected Diseases, Douglas Holtzman

Vaccine Technology II

No abstract provided.

Vaccine Technology Ii: Abstracts Of Poster Presentations, The Editors

Vaccine Technology II

No abstract provided.

Material Flow Behavior In Friction Stir Welding, Brian C. Liechty

Theses and Dissertations

Material flow in friction stir welding is largely uncharacterized due to the difficulty in material flow measurement and visualization in metals. This study investigates plasticine for use as an analog for modeling material flow in friction stir welding (FSW) of metals. Qualitative comparisons between welded plasticine and metal sections exhibit many similarities. The transient temperature response of the plasticine also shows the same qualitative behavior as welds conducted in metal. To quantify its similarity to metal, the plasticine is further analyzed through compression tests to characterize its strain, strain-rate, and temperature sensitivities. A detailed analysis is presented which defines the …

A Grounded Agent Model Of The Consumer Technology Adoption Process, Brent Alan Zenobia

Dissertations and Theses

Adoption is one of the most important concepts in the diffusion of innovations (DOI) literature, yet certain aspects of it are poorly understood. In particular, causal adoption process theory (CAPT) has been stagnant for decades and seldom subjected to critical scrutiny. In consequence, DOI research is unstable – different studies identify different factors as important.

This dissertation introduces grounded agent modeling, a hybrid methodology drawing on existing software engineering and social science techniques to construct a step-by-step explanation of how consumers make technology adoption decisions. Inductive case studies, grounded theory, and sequence analysis are used to investigate transportation mode adoption …

A Cartilage Growth Mixture Model With Collagen Remodeling: Validation Protocols, Stephen M. Klisch, Anna Asanbaeva, Sevan R. Oungoulian, Koichi Masuda, Eugene J.-Ma. Thonar, Andrew Davol, Robert L. Sah

Mechanical Engineering

A cartilage growth mixture (CGM) model is proposed to address limitations of a model used in a previous study. New stress constitutive equations for the solid matrix are derived and collagen (COL) remodeling is incorporated into the CGM model by allowing the intrinsic COL material constants to evolve during growth. An analytical validation protocol based on experimental data from a recent in vitro growth study is developed. Available data included measurements of tissue volume, biochemical composition, and tensile modulus for bovine calf articular cartilage (AC) explants harvested at three depths and incubated for 13 days in 20% fetal borine serum …

Differential Evolution Particle Swarm Optimization For Digital Filter Design, Bipul Luitel, Ganesh K. Venayagamoorthy

Electrical and Computer Engineering Faculty Research & Creative Works

In this paper, swarm and evolutionary algorithms have been applied for the design of digital filters. Particle swarm optimization (PSO) and differential evolution particle swarm optimization (DEPSO) have been used here for the design of linear phase finite impulse response (FIR) filters. Two different fitness functions have been studied and experimented, each having its own significance. The first study considers a fitness function based on the passband and stopband ripple, while the second study considers a fitness function based on the mean squared error between the actual and the ideal filter response. DEPSO seems to be promising tool for FIR …

The Effect Of Substrate Properties On Print Attributes For Gravure Printing - From Proof To Press, Yu Ju Wu

Dissertations

Gravure is the major printing process used for publication printing. In gravure printing processes, color proofing is for the purpose of checking the color to ensure that it is as desired. There is no doubt that paper properties have significant effects on the image reproduction for either printing or proofing processes. In order to achieve uniformity of printing and obtain good color reproduction performance, it is important that the all paper properties are well defined and controlled. This study investigates the correlations between paper properties and print quality/color reproduction for gravure publication printing and ink jet printing used in digital …

Mechanisms Of T Helper Cell Modulation In A Simulated Space Radiation Environment, Asma Rizvi

Loma Linda University Electronic Theses, Dissertations & Projects

Exposure to solar particle events (SPEs) poses the most serious threat to astronaut health. Due to this radiation environment, exploration of the solar system beyond Earth’s orbit entails many risks for the crew on these deep space missions. Depression or dysfunction of the immune system is a major concern due to its high radio-sensitivity; potential consequences include overwhelming infection, development of cancer, fibrosis, and poor wound healing. Astronauts are also exposed to low dose/low dose rate (LDR) radiation. A three month stay at the international space station exposes them to ~ 0.05 Gy of radiation.

C57BL/6 mice received LDR gamma-radiation …

A Case-Study Based Course On "Device Evaluation And Fda Approval", Kristen O'Halloran Cardinal

Biomedical Engineering

Preclinical evaluation of new devices and therapies is an integral part of research and development in the medical device industry, and the regulatory process for FDA approval is a major driving force behind much that goes on in a company setting. A large number of graduating biomedical engineers enter this medical device industry or a related environment upon graduation from our institution. Although these engineers are equipped to address many of the technical challenges that will arise, there is currently limited formal training in or exposure to the regulatory process that is required to bring new devices to market. Knowledge …

Articular Cartilage Tensile Integrity: Modulation By Matrix Depletion Is Maturation-Dependent, Anna Asanbaeva, Johnny Tam, Barbara L. Schumacher, Stephen M. Klisch, Koichi Masuda, Robert L. Sah

Mechanical Engineering

Articular cartilage function depends on the molecular composition and structure of its extracellular matrix (ECM). The collagen network (CN) provides cartilage with tensile integrity, but must also remodel during growth. Such remodeling may depend on matrix molecules interacting with the CN to modulate the tensile behavior of cartilage. The objective of this study was to determine the effects of increasingly selective matrix depletion on tensile properties of immature and mature articular cartilage, and thereby establish a framework for identifying molecules involved in CN remodeling. Depletion of immature cartilage with guanidine, chondroitinase ABC, chondroitinase AC, and Streptomyces hyaluronidase markedly increased tensile …

Theory, Simulation, Fabrication And Testing Of Double Negative And Epsilon Near Zero Metamaterials For Microwave Applications, Neil Patel

Master's Theses

Natural structures exhibiting simultaneous negative bulk permittivity and permeability have not yet been discovered. However, research interest over the past five years has grown with the proposition that artificial structures exhibiting these properties are realizable using specially-designed metallic inclusions embedded in host dielectric bodies. A periodic structure of metallic inclusions much smaller than the guided wavelength and embedded in a host dielectric medium is known in the physics and microwave communities as a "metamaterial". Such frequency-dependent effectively homogeneous materials may be designed to exhibit negative permeability and permittivity at certain frequencies. As predicted by electromagnetic theory, such negative index or …

Development Of A Cell Depositing System Using Inkjet Technology, Jason Robert Ozaeta

Master's Theses

In the past decade, advances in tissue engineering have allowed researchers to fabricate simple tissues. However, the process of creating these native tissues is a time consuming and inefficient process. A scaffold must first be fabricated then exposed to a sea of cells in the hopes of seeding. Furthermore, even though cells may have attached, more time must be spent in order to allow the cells to migrate to their ideal locations. To deal with this problem, researchers have investigated whether rapid prototyping principals could be adapted to facilitate the cell seeding process by placing cells in their respective locations …

Bronchial Circulation Angiogenesis In The Rat Quantified With Spect And Micro-Ct, Christian Wieholt, David L. Roerig, John B. Gordon, Steven Thomas Haworth, Robert C. Molthen, Anne V. Clough

Biomedical Engineering Faculty Research and Publications

Introduction

As pulmonary artery obstruction results in proliferation of the bronchial circulation in a variety of species, we investigated this angiogenic response using single photon emission computed tomography (SPECT) and micro-CT.

Materials and methods

After surgical ligation of the left pulmonary artery of rats, they were imaged at 10, 20, or 40 days post-ligation. Before imaging, technetium-labeled macroaggregated albumin (^99mTc MAA) was injected into the aortic arch (IA) labeling the systemic circulation. SPECT/micro-CT imaging was performed, the image volumes were registered, and activity in the left lung via the bronchial circulation was used as a marker of bronchial …

Agarose And Methylcellulose Hydrogel Blends For Nerve Regeneration Applications, Benton C. Martin, Eric J. Minner, Sherri L. Wiseman, Rebecca L. Klank, Ryan J. Gilbert

Chemical and Biochemical Engineering Faculty Research & Creative Works

Trauma sustained to the central nervous system is a debilitating problem for thousands of people worldwide. Neuronal regeneration within the central nervous system is hindered by several factors, making a multi-faceted approach necessary. Two factors contributing to injury are the irregular geometry of injured sites and the absence of tissue to hold potential nerve guides and drug therapies. Biocompatible hydrogels, injectable at room temperature, that rapidly solidify at physiological temperatures (37°C) are beneficial materials that could hold nerve guidance channels in place and be loaded with therapeutic agents to aid wound healing. Our studies have shown that thermo reversible methylcellulose …

Exploitation Of Surface Engineering Technology Research, David Kennedy

Conference Papers

Surface engineering refers to a wide range of technologies that design and modify the surface properties and characteristics of components. The applications are very broad from macro to nano and from extremely hard materials to polymeric coatings. The uses are found in many engineering, energy, gas and oil, transport, medical, cosmetic, optical, chemical and sports industries. Research in this technology is ongoing and the benefits that can be derived are enormous. The design, wear and tribological properties of components for instance have been greatly enhanced by surface engineering and the economic benefits to industries far outweigh the cost and use …

Forecasting Flying Hour Costs Of The B-1, B-2, And B-52 Bomber Aircraft, Stefanie L. Van Dyk

Theses and Dissertations

This thesis both evaluates, and presents improvements to, the current method of forecasting flying costs of Air Force aircraft. It uses depot level repairable (DLR) and consumable (CONS) data for the Air Force's bomber platforms: B-1B, B-2, and B-52H. The current forecasting method assumes a proportional relationship between costs and flying hours such that 1) when no hours are flown costs are zero, and 2) a 1% increase in flying hours will increase costs by 1%. The findings of this research indicate that applying log-linear ordinary least squares regression techniques may be an improved fit of flying cost data over …

2007 Portland Metropolitan Region Transportation System Performance Report, Robert Bertini

Civil and Environmental Engineering Faculty Publications and Presentations

Our transportation system is a key ingredient in the economy, quality of life and urban fabric of the Portland metropolitan area. It has been stated in the past that it is not possible to manage our transportation system tomorrow unless we understand how it is performing today. In this spirit, the Portland State University Center for Transportation Studies has been working with regional and statewide partners to develop new capabilities to measure, monitor and track the performance of the transportation system in real time and using archived data sources. We believe that it is possible to leverage these disparate data …

Building Benchmarks, James D. Sterling

Business and Information Technology Faculty Research & Creative Works

No abstract provided.

Optimal Allocation Of Blood Products, Godson A. Tetteh

Dissertations

The high cost of collection and the short shelf life of apheresis platelets demand efficient inventory management to reduce outdates and shortages. Apheresis platelets are licensed for seven days, and blood centers are keen on knowing the consequences of various product collection and distribution strategies. To reduce outdates, inventory managers typically distribute the older units first, thereby following first-in first-out (FIFO) policy; however, hospital blood banks would prefer that the blood center issues out the freshest units first, equivalent to a last-in first-out (LIFO) policy. This study addresses the optimal distribution policy to achieve a desired outdate, shortage and average …

Micro, Meso And Macro Materials Processing Using High-Speed Liquid Projectiles, Veljko Samardzic

Dissertations

The objective of this research is developmentof aknowledge base of materials processing by the impact of high-speed liquid projectiles. The work involved experimental study of generation and applications of high-speed liquid projectiles. The projectiles were generated by the launchers, which used gunpowder as an energy source. The experiments were carried out at the low (O.35g of the powder), middle (1.2g) and high (10g to 70g) levels of energy consumptions and at several different launchers modification.

Experimental investigation of effect of gun powder mass on energy of projectile was conducted for ductile and brittle targets. An array of experimental …

Altered Brain Activity In Autistic Children Versus Healthy Controls While Performing Simple Tasks Using Fmri, Donald Martin Adams Jr.

Theses

Functional magnetic resonance imaging (fMRI) studies dealing with Autistic children have primarily been concerned with cognitive facial recognition. Recent studies have demonstrated that Autistic children, when compared to healthy matched controls, exhibit higher neuronal activity when identifying patterns or objects, but lower levels of activity in regards to facial recognition.

The objective of this study was to examine both facial and object recognition and compare them to simple sensorimotor tasks. All subjects were administered 5 stimuli each lasting 320 seconds. Subjects were instructed to use a button press box to identify between a Person/Object and an Arrow/Object. They were then …

Process-Structure-Property Relationships Of Resorbable Desamino Tyrosine Derived Polymers : Effect Of Backbone Chemistry And Assembly On Drug Delivery, Pinar Nebol

Theses

The selection the correct biomaterial for a specific medical application plays an important role for the success of both application and the device. Since different applications require different properties, investigation and improvement of biomaterials with different properties are very important. L-tyrosine derived polymers enable the manipulation of the properties of the material by changing backbone or pendent chain structure. L-tyrosine derived polyarylate is one of the class of these materials.

This study investigates the behavior of the tyrosine derived polyarylates under in vitro conditions. The change of structure caused by incubation in phosphate buffer solution and the effect on the …

Design And Construction Of A Novel Transpalpebral Ophthalmic Tonometer, Philippe R. Moinot

Theses

Glaucoma -- a degeneration of the optic nerve- is a leading cause of blindness which is primarily caused by large fluctuations in intraocular pressure (lOP) known as diurnal variations. Because these peak in the early morning dropping off rapidly, a self administrable and inexpensive lOP home testing procedure is highly desirable. The approach contained herein -- unlike traditional Goldman applanation tonometry which requires the use of ophthalmic anesthetics and complex diagnostic equipment- describes a novel lOP measurement method consisting of concavation of the cornea or sclera through the palpebra superior by the spherical tip of an optoelectronic photodetector suspended in …

Synthesis Of Corn-Derived Carbohydrate Derivatives As Effective Multifunctional Sunscreen, Xianhong Feng

Theses

The eighty-years-old sunscreen industry is sustained by the growing incidence of skin cancer and the continual exploration of skin aging. From the UVB-induced erythema to the UVA-induced persistent pigment darkening, scientists have used versatile methods to reveal that not only does UVB damage skin but also that longer wavelengths such as UVAIL (290nm ~ 340nm) and UVAL rays (340nm ~ 400nm) trigger skin cancer, premature skin aging and immunosuppression.

To meet a significant demand for improved photoprotection, a broad-spectrum sunscreen with a high extinction coefficient has been desired. As part of our ongoing studies on isosorbide-cinnamate derivatives, this work have …

Experimental Investigation Of The Fluid Velocity Distribution In Stirred Tank Reactors Equipped With Retreat-Blade Impellers Using Laser Doppler Velocimetry, Deepak Rajesh Madhrani

Theses

Stirred tank reactors are commonly used in the pharmaceutical industry for synthesis of Active Pharmaceutical Ingredients (API's) and their intermediates. Typically, these vessels are glass-lined and are provided with a single retreat-blade glass-lined impeller and a single baffle. Despite their ubiquitous utilization in the pharmaceutical industry for at least the past 40 years, the mixing characteristics of these systems have not been studied to any great extent, making it difficult to predict mixing performance in any given operation.

In this work, the velocity distribution inside the typical glass-lined vessel/impeller system was experimentally quantified using Laser Doppler Velocimetry (LDV), which is …

Radiation-Induced Osteoporosis: Bone Quantity, Architecture, And Increased Resorption Following Exposure To Ionizing Radiation, Jeffrey Willey

All Dissertations

Skeletal complications from radiation therapy have been described for breast, brain, pelvic, and blood cancers. These problems include atrophy, fractures, and osteoradionecrosis. Improved survivorship rates of cancer patients receiving radiotherapy increases the importance of understanding the causal mechanisms and long-term effects of radiation-induced bone loss. One such long-term effect is bone fractures following radiation therapy for cancer treatment. The incidence of hip fractures is significantly increased following targeted radiotherapy for cancer. This decline in bone health can have a severe impact on the patient's functional capabilities. This damage to bone following irradiation is thought to involve damage to both osteoblasts …