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Solid Oxide Fuel Cell Electrode Characterization And Improvement For Fuel Flexibility And Supplemental Power Production, Isaiah D. Kellogg

Doctoral Dissertations

"Solid oxide fuel cells (SOFC) were fabricated and the electrodes tested for their individual catalytic effectiveness in various fuels by exposing each electrode to mixed gas while the opposite electrode was exposed to its respective pure gas. Mixed hydrogen and oxygen gas was successfully utilized as fuel in a single chamber SOFC (SC-SOFC). The conditions at which the porous nickel-yttria-stabilized zirconia (Ni-YSZ) cermet anode performed well did not significantly overlap the conditions at which the La₀.₈Sr₀.₂Fe₀.₈Co₀.₂ oxide (LSCF) cathode performed well, but there was significant catalytic activity at both electrodes which increased the open circuit voltage (OCV) beyond that predicted …

Crack Detectability And Durability Of Coaxial Cable Sensors In Reinforced Concrete Bridge Applications, Genda Chen, Ryan D. Mcdaniel, Michael A. Brower, David Pommerenke

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

The working mechanism and the measurement principle of topology-based crack sensors made of coaxial cables are briefly reviewed. The sensitivity, spatial resolution, and ruggedness of two coaxial cable sensors, respectively made of rubber and Teflon dielectric materials, were compared and validated with laboratory testing of a 4/5-scale, T-shaped, reinforced concrete beam-column specimen. Two Teflon sensors were installed on one of the solid decks of a three-span continuous highway bridge to investigate their durability and measurement repeatability. Laboratory tests indicated that both types of sensors have high sensitivity, but the Teflon sensor has a higher spatial resolution and a negligible spillover …

Characterization Of The Corrosion Protection Mechanism Of Cerium-Based Conversion Coatings On High Strength Aluminum Alloys, William R. Pinc

Doctoral Dissertations

"The aim of the work presented in this dissertation is to investigate the corrosion protection mechanism of cerium-based conversion coatings ( CeCCs) used in the corrosion protection of high strength aluminum alloys. The corrosion resistance of CeCCs involves two general mechanisms; barrier and active. The barrier protection mechanism was influenced by processing parameters, specifically surface preparation, post-treatment, and the use of gelatin. Post-treatment and the addition of gelatin to the coating solution resulted in fewer cracks and transformation of the coating to CeP0₄, which increased the corrosion resistance by improving the barrier aspect of CeCCs. CeCCs were found to best …

Energy Reduction In Automotive Paint Shops A Review Of Hybrid/Electric Vehicle Battery Manufacturing, Claudia Patricia Arenas Guerrero

University of Kentucky Master's Theses

Automotive industry is facing fundamental challenges due to the rapid depletion of fossil fuels, energy saving and environmental concerns. The need of sustainable energy development has motivated the research of energy reduction and renewable energy sources. Efficient use of energy in vehicle manufacturing is demanded, as well as an alternative energy source to replace gasoline powered engines. In this thesis, we introduce a case study at an automotive paint shop, where the largest amount of energy consumption of an automotive assembly plant takes place. Additionally, we present a summary of recent advances in the area of hybrid and electrical vehicles …

Wideband, High Data Rate Ku-Band Modulator Driver Amplifier For High Reliability Spaceborne Applications, Jeremy D. Gassmann

Browse all Theses and Dissertations

The increased demand for high resolution satellite imagery for government, military, and commercial applications is driving the need for high data rate, millimeter-wave transmission systems to relay imagery information to a ground-based end user. An important aspect of this system which interfaces digital information to the RF domain is the modulator driver. The current trend in miniaturization of electronics leaves systems more vulnerable to single-event radiation effects in spaceborne applications. In an effort to overcome this deficiency, a wideband, high data rate modulator driver circuit has been designed, built, and tested using only high reliability space rated electronic components. To …

Impact Of Culture And Age On The Use Of Social Networking Websites, Ramya Reddy Ponnavolu

Browse all Theses and Dissertations

Social networking websites have become very popular amongst people of all ages in recent times. These websites have brought into existence a new form of data - 'User generated content'. Companies everywhere have begun to identify the potential of these sites and have commenced efforts to take advantage of the profitable opportunities available. In spite of all this, it is reasonable to say that the latent possibilities in social networking sites are yet to be fully explored. This is due to the fact that the technology is still young and research on its potential is still ongoing. The current research …

Prognosis: A Wearable System For Health Monitoring Of People At Risk, Alexandros A. Pantelopoulos

Browse all Theses and Dissertations

Wearable Health Monitoring Systems (WHMS) have drawn a lot of attention from the research community and the industry during the last decade. The development of such systems has been motivated mainly by increasing healthcare costs and by the fact that the world population is ageing. In addition to that, RandD in WHMS has been propelled by recent technological advances in miniature bio-sensing devices, smart textiles, microelectronics and wireless communications techniques. These portable health systems can comprise various types of small physiological sensors, which enable continuous monitoring of a variety of human vital signs and other physiological parameters such as heart …

Computer-Based Skeletal Age Assessment Using Hand/Wrist Radiographs In Children 8-18 Years Old, Zhihong Ni

Browse all Theses and Dissertations

Children's skeletons mature at different rates, and they can be affected by a variety of factors including disease, hormone imbalance or genetics. The assessment of skeletal maturity is a frequently performed procedure that allows the detection of hormonal, growth or genetic disorders. Several methods have been developed to estimate skeletal maturity. Most methods evaluate hand/wrist radiographs using indicators such as the ratios of various bone widths, the onset of the ossification of epiphysis and epiphyseal-diaphyseal fusion. Among those methods, the FELS method differs from others in the application of different grades to each indicator and the provision of a confidence …

Charaterization Of Chlorpyrifos Toxicity On The Pancreatic Beta Cell Line Rinm5f, Zhongyu Yan

Browse all Theses and Dissertations

Chlorpyrifos (CPF) is a well-known organophosphate (OP) insecticide that inhibits acetylcholinesterase (AChE). Organophosphates have been shown to induce hyperglycemia in both humans and animals that cannot be explained by AChE inhibition alone. Pancreatic β-cells are responsible for secreting insulin and playing a fundamental role in glucose homeostasis. The aim of this research was to investigate CPF toxicity on the insulin secreting β-cell line RINm5f (RIN). In the first part of this dissertation, we determined that cytotoxic concentrations of CPF between 50 µM and 200 µM induced a dose-dependent increase in RIN cell apoptotic and necrotic death (p<0.05). Lower doses, i.e., 5-25 µM did not induce apoptosis or necrosis. In further mechanistic studies, inhibitors of c-Jun N-terminal kinase (JNK) and P38 pathways, i.e., SP600125 and SB202190, successfully attenuated CPF-induced apoptosis (p<0.05), suggesting cell death is mediated by JNK and/or p38. In addition, N-Acetyl-L-cysteine (NAC), an antioxidant, inhibited apoptosis suggesting that oxidative stress is also involved in RIN cell death. In the second part of this dissertation, low dose CPF's effects on insulin synthesis and secretion was studied. Our results showed that RIN cells treated with CPF for 4 hr exhibited a dose-dependent decrease in insulin secretion in response to stimulation by 50 mM potassium (p<0.05). Insulin secretion stimulated by 25 mM glucose also showed significant decreases upon incubation with various doses of CPF (p<0.05). Insulin synthesis involves proteolytic cleavage of proinsulin at two specific sites. The enzymes responsible for promoting proinsulin cleavage, i.e, prohormone convertase (PC) 1/3 and 2 (PC2), contain a serine hydrolase catalytic triad, His-Asp-Ser, similar to AChE. CPF modification of PC enzymes similar to AChE, could potentially interrupt the conversion of proinsulin to insulin and disrupt insulin secretion. PC2 enzyme activity was significantly inhibited by CPF at concentrations as low as 10 µM (p<0.01). RIN cells, for the first time, were found to secrete proinsulin was through a constitutive instead of a regulated pathway. In summary, our results show that CPF not only exerts a direct cytotoxic effect at concentrations above 50 µM, but also significantly impairs insulin secretion at lower doses. Low dose CPF could potentially affect endocrine function in vivo by inhibiting the proinsulin processing enzyme PC2.

A Novel Synergistic Diagnosis Methodology For Identifying Abnormalities In Wireless Capsule Endoscopy Videos, Alexandros Karargyris

Browse all Theses and Dissertations

Wireless Capsule Endoscopy (WCE) is a new technology that allows medical personnel to view the gastrointestinal (GI) mucosa. It is a swallowable miniature capsule device the size of a pill that transmits thousands of screenshots of the digestive tract to a wearable receiver. When the procedure finishes the video is uploaded to a workstation for viewing. Capsule Endoscopy has been established as a tool to identify various gastrointestinal (GI) conditions, such as blood-based abnormalities, polyps, ulcers, Crohn's disease in the small intestine, where the classical endoscopy is not regularly used.

As of 2009 the market is dominated by Given Imaging …

Design And Development Of A Wireless Data Acquisition System For Fall Detection, Anoop Hanchinamane Ramakrishna

Browse all Theses and Dissertations

With the mortality rate of the elderly on the rise due to fall related incidents, fall detection has become an important entity in the geriatric health care sector. The study conducted in this thesis involved the design and development of a Wireless Data Acquisition System (WDAS) with Bluetooth capabilities interfaced to pulse width modulated gyroscopic sensors. Each sensor used has a reference output pulse width which changes when rotated about its sensitive axis.Part of the effort involves the design and development of two versions of printed circuit boards for the application. Each board includes a Parallax Propeller micro- controller in …

Algorithmic Techniques Employed In The Quantification And Characterization Of Nuclear Magnetic Resonance Spectroscopic Data, Paul Edward Anderson

Browse all Theses and Dissertations

Nuclear magnetic resonance (NMR) based metabolomics is a developing research field with broad applicability, including the identification of biomarkers associated with pathophysiologic changes, sample classification based on the mechanism of toxicity, and clinical diagnosis. Intrinsic to these applications is the need for statistical and computational techniques to facilitate the associated data analysis. Further, a typical 1H NMR spectrum of pure proteins, biofluids, or tissue may contain thousands of resonances (i.e., peaks), thus, a pure visual inspection is insufficient to fully utilize the spectral information.

Common practice within the NMR-based metabolomics community is to evaluate and validate novel algorithms on empirical …

Semantic Provenance: Modeling, Querying, And Application In Scientific Discovery, Satya Sanket Sahoo

Browse all Theses and Dissertations

Provenance metadata, describing the history or lineage of an entity, is essential for ensuring data quality, correctness of process execution, and computing trust values. Traditionally, provenance management issues have been dealt with in the context of workflow or relational database systems. However, existing provenance systems are inadequate to address the requirements of an emerging set of applications in the new eScience or Cyberinfrastructure paradigm and the Semantic Web. Provenance in these applications incorporates complex domain semantics on a large scale with a variety of uses, including accurate interpretation by software agents, trustworthy data integration, reproducibility, attribution for commercial or legal …

Fault Diagnosis Of Vehicular Electric Power Generation And Storage, Hithesh Sanjiva Uliyar

Browse all Theses and Dissertations

Automotive vehicles are becoming increasingly dependent on electric power, and this trend will accelerate. The health of the vehicular electric power generation and storage (EPGS) system is crucial to enhance vehicle safety, fuel economy, and customer satisfaction.

In this research, a state-of-health (SOH) monitoring method is developed for automotive EPGS system, focusing on alternator related faults. Parity relations, characterizing the correlation among EPGS system signals under normal operating conditions, are generated using principal/minor component analysis techniques. Based on a design of structured residuals, the faults under consideration, including shorted diodes, belt slippage, and regulator fault, are successfully detected and isolated. …

Domain-Specific Core Self-Evaluations And Stressors As Predictors Of Strains, Michael Raymond Hoepf

Browse all Theses and Dissertations

The current study examines the use of a frame-of-reference (FOR) in the evaluation of core self-evaluations, stressors and strains. The study investigates the prediction that using a FOR that matches predictors and outcomes will result in a stronger relationship between the constructs being measured, specifically CSE, stressors, and strains. In addition, the study examines the extent to which following this procedure will add incremental validity after non-contextualized predictors are controlled. The hypotheses in this study were generally supported, although the hypotheses related to the school domain were not supported as strongly as those related to general and work domain. The …

Structural Health Monitoring Of A Thermal Protection System For Fastener Failure With A Validated Model, Randy Joseph Tobe

Browse all Theses and Dissertations

Air vehicles flying at hypersonic speeds encounter extreme thermal, aerodynamic and acoustic loads. To maintain the structural integrity of the flight vehicle, a thermal protection system shields the main structure from these loads. Therefore, maintaining the health of the thermal protection system is critical for a successful mission and vehicle safety. One of the more common types of failure in a mechanically attached thermal protection system is fastener failure. Since reducing vehicle turnaround between flights is desired, creating an automated system to perform structural health monitoring on the fastener health of the thermal protection system is needed. This can be …

Cellular Effects Of Replicating A Polypurine-Polypyrimidine Sequence And The Interactions Of Due-B With Replication Proteins, Shere Lynne Myers

Browse all Theses and Dissertations

This work investigates two questions regarding DNA replication. The first aim examines the interactions of DUE-B with replication proteins and the second explores the cellular effects of replicating a polypurine polypyrimidine sequence in human cells.

DUE-B siRNA decreases the chromatin binding of essential replication proteins Cdc45, PCNA and RPA. DUE-B also co-immunoprecipitates with Cdc45 and TopBP1. In vitro kinase assays suggest that the checkpoint protein ATR may phosphorylate DUE-B. These experiments lend further evidence that DUE-B plays an important role in the initiation of eukaryotic DNA replication.

To investigate the effects of replicating a polypurine-polypyrimidine sequence prone to secondary structure …

Synergy Between Biology And Systems Resilience, Ashik Chandra

Masters Theses

"Resilient systems have the ability to endure and successfully recover from disturbances by identifying problems and mobilizing the available resources to cope with the disturbance. Resiliency lets a system recover from disruptions, variations, and a degradation of expected working conditions. Biological systems are resilient. Immune systems are highly adaptive and scalable, with the ability to cope with multiple data sources, fuse information together, makes decisions, have multiple interacting agents, operate in a distributed manner over a multiple scales, and have a memory structure to facilitate learning. Ecosystems are resilient since they have the capacity to absorb disturbance and are able …

Multiwall Carbon Nanotubes Alter The Thermal Profile And Antibiotic Elution Of Orthopaedic Bone Cement, Alison Carroll Tickle

University of Kentucky Master's Theses

Multiwall carbon nanotubes (MWNTs) have extraordinary mechanical and thermal transport properties. They significantly improve the static and dynamic mechanical properties of acrylic orthopaedic bone cement when added to the dry cement polymer powder. Understanding the role MWNTs play on bone cement polymerization temperatures will lead to improved mechanical integrity of the cement-bone interface in joint arthroplasties. It was determined through thermal testing that MWNTs increased the polymerization time of the methylmethacrylate by 45-460% and decreased the peak exothermic temperature of bone cement with and without antibiotics. The flow of heat produced during polymerizing cement was reduced 25-85% with the addition …

Robust Dynamic Balance Of Ap-1 Transcription Factors In A Neuronal Gene Regulatory Network., Gregory M Miller, Babatunde A Ogunnaike, James S Schwaber, Rajanikanth Vadigepalli

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: The octapeptide Angiotensin II is a key hormone that acts via its receptor AT1R in the brainstem to modulate the blood pressure control circuits and thus plays a central role in the cardiac and respiratory homeostasis. This modulation occurs via activation of a complex network of signaling proteins and transcription factors, leading to changes in levels of key genes and proteins. AT1R initiated activity in the nucleus tractus solitarius (NTS), which regulates blood pressure, has been the subject of extensive molecular analysis. But the adaptive network interactions in the NTS response to AT1R, plausibly related to the development of …

Freeform Reflector Design With Extended Sources, Florian Fournier

Electronic Theses and Dissertations

Reflector design stemmed from the need to shape the light emitted by candles or lamps. Over 2,000 years ago people realized that a mirror shaped as a parabola can concentrate light, and thus significantly boosts its intensity, to the point where objects can be set afire. Nowadays many applications require an accurate control of light, such as automotive headlights, streetlights, projection displays, and medical illuminators. In all cases light emitted from a light source can be shaped into a desired target distribution with a reflective surface. Design methods for systems with rotational and translational symmetry were devised in the 1930s. …

The Characterization Of Aerosol Particle Contamination As The Result Of Carry-Over And Cross-Over In Enthalpy Wheels, Rodney G. Handy, Kevin Rodgers, Jon Wang, Matt Tumey, Danny Rodriguez, William J. Hutzel

School of Engineering Technology Faculty Publications

This paper provides results from a study that characterized the particle distributions found from variable contaminated airstreams in energy recovery ventilators (ERV) during two different test scenarios. The first scenario involved the measurement of the particulate concentrations during an operational situation when the pressure differential forces cross-flow leakage between the exhaust and intake streams. The second scenario involved the characterization of aerosol particulate concentrations from the carry-over contamination when the wheel was not in operation. The findings from the study concluded that if a source of aerosol particulate matter is present in an environment utilizing an ERV system, then cross-over …

Water Resources, Health, And The Sustainability Of Interventions To Achieve Water And Sanitation Targets Of The Millennium Development Goals In A Changing World, Lauren M. Fry

Dissertations, Master's Theses and Master's Reports - Open

This dissertation addresses sustainability of rapid provision of safe water and sanitation required to meet the Millennium Development Goals. Review of health-related literature and global statistics demonstrates engineers' role in achieving the MDGs. This review is followed by analyses relating to social, environmental, and health aspects of meeting MDG targets.

Analysis of national indicators showed that inadequate investment, poor or nonexistent policies and governance are challenges to global sanitation coverage in addition to lack of financial resources and gender disparity. Although water availability was not found to be a challenge globally, geospatial analysis demonstrated that water availability is a potentially …

Use Of A 3d Perfusion Bioreactor With Osteoblasts And Osteoblast/Endothelial Cell Co-Cultures To Improve Tissue-Engineered Bone, Matthew J. Barron

Dissertations, Master's Theses and Master's Reports - Open

The delivery of oxygen, nutrients, and the removal of waste are essential for cellular survival. Culture systems for 3D bone tissue engineering have addressed this issue by utilizing perfusion flow bioreactors that stimulate osteogenic activity through the delivery of oxygen and nutrients by low-shear fluid flow. It is also well established that bone responds to mechanical stimulation, but may desensitize under continuous loading. While perfusion flow and mechanical stimulation are used to increase cellular survival in vitro, 3D tissue-engineered constructs face additional limitations upon in vivo implantation. As it requires significant amounts of time for vascular infiltration by the host, …

Influence Of Traumatic Impaction And Pathological Loading On Knee Menisci, Megan Leigh Killian

Dissertations, Master's Theses and Master's Reports - Open

Nearly half of the US population faces the risk of developing knee osteoarthritis (OA). Both in vitro and in vivo studies can aid in a better understanding of the etiology, progression, and advancement of this debilitating disorder. The knee menisci are fibrocartilagenous structures that aid in the distribution of load, attenuation of shock, alignment and lubrication of the knee. Little is known about the biochemical and morphological changes associated with knee menisci following altered loading and traumatic impaction, and investigations are needed to further elucidate how degradation of this soft tissue advances over time. The biochemical response of porcine meniscal …

Mse News 2010, Department Of Materials Science And Engineering, Michigan Technological University

Department of Materials Science and Engineering Annual Reports

Table of Contents

• MSE Welcomes New Professors
• Professor Emeritus Passes
• Alumni Achieves Milestone
• Hydrogen Storage Research
• Student Accomplishments
• Staff News
• Alumni News

2009-2010 Che Newsletter, Department Of Chemical Engineering, Michigan Technological University

Department of Chemical Engineering Newsletters

Table of Contents

• Department
• Students
• Alumni and Friends
• Faculty and Staff
• Industrial Advisory Board

Production And Characterization Of Novel Air Filtration Media, Elizabeth Skomra

All Dissertations

HEPA and ULPA filtration systems have proven to be an advantageous instrument in removing common contaminants from the air. However, an increased pressure drop due to the build-up of particulates on the filters results in its inevitable decrease in performance. Improving current filtration systems would include increasing collection efficiency all the while either maintaining or reducing the differential pressure drop in order to extend the life of the filter. One method of improving collection efficiency would be viable by increasing the amount of surface area within the filter media by glass fibers because of their inherent quality of being smaller …

The Development Of A Mesenchymal Stem Cell Based Biphasic Osteochondral Tissue Engineered Construct, Scott Maxson

All Dissertations

The ability of human articular cartilage to respond to injury is poor. Once cartilage damage has occurred, an irreversible degenerative process can occur and will often lead to osteoarthritis (OA). An estimated 26.9 million of U.S. adults are affected by OA. Osteochondral grafting is currently used to treat OA and osteochondral defects; however, complications can develop at the donor site and defect area. Osteochondral tissue engineering provides a potential treatment option and alternative to osteochondral grafting. The long term goal of this work is to develop a tissue engineered mesenchymal stem cell (MSC) based osteochondral construct to repair cartilage damage. …

Prediction Of Brain Tumor Progression Using A Machine Learning Technique, Yuzhong Shen, Debrup Banerjee, Jiang Li, Adam Chandler, Yufei Shen, Frederic D. Mckenzie, Jihong Wang, Nico Karssemeijer (Ed.), Ronald M. Summers (Ed.)

Electrical & Computer Engineering Faculty Publications

A machine learning technique is presented for assessing brain tumor progression by exploring six patients' complete MRI records scanned during their visits in the past two years. There are ten MRI series, including diffusion tensor image (DTI), for each visit. After registering all series to the corresponding DTI scan at the first visit, annotated normal and tumor regions were overlaid. Intensity value of each pixel inside the annotated regions were then extracted across all of the ten MRI series to compose a 10 dimensional vector. Each feature vector falls into one of three categories:normal, tumor, and normal but progressed to …