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Articles 1021 - 1050 of 41051
Full-Text Articles in Entire DC Network
Development Of A Novel Innovative Umbrella Falsework System For Concrete Slabs, Abdelazem Hashim
Development Of A Novel Innovative Umbrella Falsework System For Concrete Slabs, Abdelazem Hashim
Theses and Dissertations
Formwork is one of the major elements that contribute to the cost and duration of concrete building projects. This is why optimizing such an element can lead to huge savings to all parties involved in the construction projects. With contractors facing huge challenges in such a competitive industry and employers seeking the least price and least duration for their projects, contractors are constantly under the obligations of finding the best alternatives to deliver their projects in terms of both time and money. Therefore, the main aim of this research project is to develop a falsework system, where the falsework system …
Sustainable Construction Materials In The Middle East: Model Development For Materials Selection, Taha Ahmed Omar Madu
Sustainable Construction Materials In The Middle East: Model Development For Materials Selection, Taha Ahmed Omar Madu
Theses and Dissertations
The construction industry, a major driver of economic development in the Middle East, is simultaneously a leading contributor to carbon emissions, resource depletion, and environmental degradation. Amid rapid urbanization in countries such as Egypt, Saudi Arabia, and the United Arab Emirates, the adoption of sustainable construction materials has emerged as a critical strategy for mitigating environmental and societal impacts while advancing regional development objectives. This thesis is organized along two interrelated directions: first, it delivers a comprehensive assessment of the current adoption, challenges, and opportunities associated with the use of sustainable construction materials across the three target countries; second, it …
Proposed Modifications To The Egyptian Concrete Code Based On A Comprehensive Sustainability Assessment Of Portland Cement Alternatives For Climate Change Mitigation, Yasmin Elhakim
Theses and Dissertations
Climate change is a major challenge facing planet earth today. This phenomenon is foreseen to continue to represent a major concern for decades to come. The construction industry is one of the most polluting sectors worldwide and is considered one of the top greenhouse gas emitters. Egypt, in particular, is one of the most vulnerable countries to the adverse effects of climate change. The construction sector plays a major role in Egypt’s economy, contributing significantly to the national GDP, yet it also represents one of the country’s largest greenhouse gas emitters. However, the Egyptian Concrete Code does not enforce the …
Models Of Change: Communicating To Your Funder And Stakeholders How You Believe Your Project Will Succeed, Jean Mclaughlin, Thuy Vu, Noe Vargas Hernandez, Arturo A. Fuentes
Models Of Change: Communicating To Your Funder And Stakeholders How You Believe Your Project Will Succeed, Jean Mclaughlin, Thuy Vu, Noe Vargas Hernandez, Arturo A. Fuentes
Civil Engineering Faculty Publications
No abstract provided.
Characterizing Indoor Surface Voc Contamination After The 2025 Los Angeles Fires, Brett W. Stinson, Emily Lei, Elliott T. Gall
Characterizing Indoor Surface Voc Contamination After The 2025 Los Angeles Fires, Brett W. Stinson, Emily Lei, Elliott T. Gall
Mechanical and Materials Engineering Faculty Publications and Presentations
We quantify volatile organic compound (VOC) emissions from indoor surface swabs and portable air cleaner (PAC) filters collected in a home 30 days after the 2025 Los Angeles wildland-urban interface (WUI) fires. We calculate emissions for 17 fire-relevant compounds. Surface emissions exceeded those of clean controls, and emissions from a windowsill in a room without a PAC were ∼15× and ∼2× higher for benzene and toluene, respectively, than rates reported in the literature for comparable materials unaffected by smoke/soot. Particle filters installed in PACs at the start of the fire emitted aromatics at rates comparable to those reported in a …
A Proposed Vision To Activate Smart Urban Growth Concepts For The New Egyptian Cities, Nirman M. El-Sayed, Mamdouh A. Al-Minshawi
A Proposed Vision To Activate Smart Urban Growth Concepts For The New Egyptian Cities, Nirman M. El-Sayed, Mamdouh A. Al-Minshawi
Mansoura Engineering Journal
Smart urban growth is the ideal solution to urban problems within the cities of the fourth generation in Egypt, and despite this, most of them depend on traditional urban thought without activating "Smart Urban Growth", which is known to maintain lands from deterioration and make societies suitable for living and providing the necessary services. The goal of research to set standards to activate smart urban growth as a thought that keeps pace with sustainable urban development and Egypt's 2030 vision, work to use the global smart cities approach and how they reach intelligence. While the research follows the "analytical" deductive …
The Evolution Of Mro Outsourcing: Global Trends, Regulatory Challenges, And Strategic Considerations In Aviation Maintenance, David C. Ison
The Evolution Of Mro Outsourcing: Global Trends, Regulatory Challenges, And Strategic Considerations In Aviation Maintenance, David C. Ison
Journal of Aviation Technology and Engineering
The maintenance, repair, and overhaul (MRO) industry plays a critical role in ensuring the safety, efficiency, and sustainability of the global aviation sector. As airlines seek to reduce costs, optimize operations, and access specialized expertise, MRO outsourcing has become an increasingly prevalent strategy. This essay examines the key drivers of MRO outsourcing, including cost reduction, access to advanced technologies, and the focus on core competencies. The essay also explores emerging trends such as the rise of new MRO hubs in Asia and the Middle East, the integration of predictive maintenance and artificial intelligence, and the growing emphasis on environmental sustainability. …
Polar Reconnaissance & Imagining Survey (Polaris), Max Brooks, Zion Carpenter, Isabel La Coss
Polar Reconnaissance & Imagining Survey (Polaris), Max Brooks, Zion Carpenter, Isabel La Coss
Student Research Symposium (SRS)
In preparation for the permanent human presence on the lunar south pole as part of the ARTEMIS Accords, planned human excursions will conduct science on regions of interest to locate resources for sustained habitation. The objective of the Polar Reconnaissance & Imaging Survey simulation is to take a predetermined region sized image of a planned astronaut excursion site to identify terrain features and threats. This shall be a satellite mission control (MCC) simulation with four Earth-based satellite console operators, and one moon-based EVA encompassing.
Contrasting Coastal Dune Environments In Chile, Aurora Christianson
Contrasting Coastal Dune Environments In Chile, Aurora Christianson
Student Research Symposium (SRS)
Emerging coastalization and urbanization threats to the prehistoric Concón Dunes and Humedal de Mantagua coastal area of Chile is being investigated by researchers via uncrewed aircraft systems (UAS). Four UAS were utilized: Anzu Raptor T, DJI Mavic 3E, DJI Mavic 3M, and DJI Air 3 to collect various images of the coastal dunes. Multispectral and RGB cameras gather images by photogrammetry to create orthomosaics and monitor vegetation indexes in Pix4Dmapper. Thermal cameras provided images in rainbow, white hot infrared, and black hot infrared schemes to monitor wildlife and vegetation. The normalized difference vegetation index (NDVI) was calculated to visualize overall …
Intravascular Ultrasound Is More Accurate Than Angiography In Arteriovenous Vascular Access Lesions, James W. Decker, Dima Banihani, Curtis Honshideler, Saran Lotfollahzadeh, David Jasen Wu Wong, Alik Farber, Jeffrey J. Siracuse, Najia Idrees, Laura Dember, Mohammad Bader, Suvranu Ganguli, Vijaya Kolachalama, Tarek Shazly
Intravascular Ultrasound Is More Accurate Than Angiography In Arteriovenous Vascular Access Lesions, James W. Decker, Dima Banihani, Curtis Honshideler, Saran Lotfollahzadeh, David Jasen Wu Wong, Alik Farber, Jeffrey J. Siracuse, Najia Idrees, Laura Dember, Mohammad Bader, Suvranu Ganguli, Vijaya Kolachalama, Tarek Shazly
Faculty Publications
Background:
Conventional angiography remains the standard diagnostic modality for arteriovenous (AV) access dysfunction in hemodialysis patients, but its geometric accuracy is limited. Intravascular ultrasound (IVUS) offers superior lesion detection, yet its absolute measurement accuracy remains uncertain. Using three-dimensional (3D) printed vascular conduits as reference standards, we assessed the accuracy of IVUS versus angiography, hypothesizing that complex conduit geometry, quantified by Gaussian curvature, would exacerbate angiographic error.
Methods
Clinically relevant AV access geometries were modeled with computer-aided design (CAD) and fabricated using 3D printing. Lumen diameters were measured by contrast angiography and IVUS and compared with CAD dimensions. Conduit geometry was …
In Situ Detection Of Dead Cells From Live Cells Via A Dc Plus Low Frequency Ac Resistive Pulse Sensor, Jiang Zhe, Ge Zhang, Joseph Ketchum, Ashely Wong
In Situ Detection Of Dead Cells From Live Cells Via A Dc Plus Low Frequency Ac Resistive Pulse Sensor, Jiang Zhe, Ge Zhang, Joseph Ketchum, Ashely Wong
University Research
Differentiation and detection of live and dead cells are critical for assessing cell viability in biomedical research, evaluating drug efficacy, and monitoring cytotoxicity in therapeutic applications. We present a microfluidic sensor that consists of two successive resistive pulse sensing channels. An excitation signal composed of a low-frequency AC (75 kHz) component and a DC bias was used to measure four key parameters. Through the AC measurement, differences in cell impedance causes variations in phase angle and voltage peak. From the DC measurement, cell size can be inferred from the resistive pulse magnitude, and the cell’s zeta potential is represented by …
Finding Research Datasets And Evaluating Data Quality, Ibis Anette Moreno-Lozano Phd.
Finding Research Datasets And Evaluating Data Quality, Ibis Anette Moreno-Lozano Phd.
Day Family Research Lab Workshop Series
No abstract provided.
Building And Sustaining Chosen Family Amongst Low-Income First-Generation Engineers, Justin C. Major
Building And Sustaining Chosen Family Amongst Low-Income First-Generation Engineers, Justin C. Major
First-Generation Symposium
Support is integral for low-income first-generation student success in and out of engineering, particularly because of the role support plays in building belonging. Students receive support from many individuals including their traditional and chosen families. While traditional family are those family “assigned at birth,” chosen family are those family you pick and choose, inclusive of teachers, friends, and others. Our research group’s (ASPIRE) extensive work on the topic has documented how chosen family come to be and why they are important for low-income first-generation success. Amongst many components, we have found that chosen family are more trustable given their authenticity …
Uav-Deployable Open-Source Sensor Nodes For Spatial And Temporal In Situ Water Quality Monitoring And Mapping, Matthew Burnett, Mohamed Abdelwahab, Joud N. Satme, Austin Downey, Gabriel Barahona Smith, Antonio Fonce, Jasim Imran
Uav-Deployable Open-Source Sensor Nodes For Spatial And Temporal In Situ Water Quality Monitoring And Mapping, Matthew Burnett, Mohamed Abdelwahab, Joud N. Satme, Austin Downey, Gabriel Barahona Smith, Antonio Fonce, Jasim Imran
Faculty Publications
Cost efficient, spatially resolved water quality monitoring is essential for managing pollution and protecting aquatic ecosystems. This study presents a low-cost (approximately USD 200), open-source, unmanned aerial vehicle (UAV)-deployable in situ sensor node for real-time assessment of surface-water conditions. The system integrates sensors for pH, turbidity, temperature, and total dissolved solids (TDSs), with onboard data logging and real-time clock (RTC) synchronization. Bench validation of the sensor package yielded mean absolute percentage errors of 1.34% for pH, 5.23% for TDS, and 0.81% for temperature, and the device operated continuously for 42 h. Field deployment demonstrated its ability to resolve spatial gradients, …
An Autonomous Robotic System For Object Retrieval And Delivery: Enhancing Independence For Users Living With Disability And Older Adults, Jincheng Li, Chenghao Lin, Amna Mazen, Youssef A. Bazzi
An Autonomous Robotic System For Object Retrieval And Delivery: Enhancing Independence For Users Living With Disability And Older Adults, Jincheng Li, Chenghao Lin, Amna Mazen, Youssef A. Bazzi
Michigan Tech Publications
As the global population ages, there is a growing need for assistive technologies to help older adults maintain their independence. This work presents a cost-effective autonomous socially assistive robot designed for object retrieval and delivery, enhancing accessibility in home environments. The system is built on the Robot Operating System (ROS) framework and integrates three key components: the Pioneer P3-DX mobile robot for autonomous navigation, the ReactorX-200 robotic arm for pick-and-place operations, and the Kinect v2 RGB-D camera for object detection and localization. Users interact with the robot through natural language processing by issuing voice commands to retrieve various objects. Microsoft …
Resilient Grid Architectures For High Renewable Penetration: Electrical Engineering Strategies For 2030 And Beyond, Ehab Bayoumi
Resilient Grid Architectures For High Renewable Penetration: Electrical Engineering Strategies For 2030 And Beyond, Ehab Bayoumi
Mechanical Engineering
The global shift toward decarbonized power systems is driving unprecedented penetration of variable renewable energy sources, especially wind and solar PV. Legacy grid architectures, built around centralized, dispatchable synchronous generation, are ill-suited to manage the bidirectional power flows, reduced inertia, and new stability constraints introduced by inverter-based resources. Existing research offers deep but fragmented insights into individual elements of this transition, such as advanced power electronics, microgrids, or market design, but rarely integrates them into a coherent architectural vision for resilient, high-renewable grids. This review closes that gap by synthesizing technical, architectural, and institutional perspectives into a unified framework for …
A Comprehensive Review Of Food Waste Management In Attaining Sdg 12.3 Goals: Insights From Asian Countries, Ping Hu, Lotifa Tamanna Toma, Ashraful Alam, Md. Tanvir Ahmmed, Md. Jahidul Islam, Kazi Farhana, Marjia Sultana, Miraj Ahmed Bhuiyan
A Comprehensive Review Of Food Waste Management In Attaining Sdg 12.3 Goals: Insights From Asian Countries, Ping Hu, Lotifa Tamanna Toma, Ashraful Alam, Md. Tanvir Ahmmed, Md. Jahidul Islam, Kazi Farhana, Marjia Sultana, Miraj Ahmed Bhuiyan
Civil and Environmental Engineering Faculty Publications and Presentations
Food waste is one of the most important world-wide challenges whose environmental, economic and social impacts have far-reaching effects that include contributing to greenhouse gas emissions, resources depletion as well as the rising levels of food insecurity. These problems are further intensified in Asia due to high rate of urbanization, population growth, changing dietary habits, and lack of waste management facilities. These conditions complicate the fact that countries are increasingly struggling to achieve the United Nations Sustainable Development Goal (SDG) 12.3, which is to ensure that by 2030, half of the world has dropped per-capita food waste, and food losses …
Structural And Mechanical Properties Facilitate Shock Wave Damping By Helmet-Like Orbital Hoods In Snapping Shrimp, Mia Kazel, Rebekah E. Cammack, Alexandra C.N. Kingston, Ahmed A. Alshareef, Tarek Shazly, Daniel Isaac Speiser
Structural And Mechanical Properties Facilitate Shock Wave Damping By Helmet-Like Orbital Hoods In Snapping Shrimp, Mia Kazel, Rebekah E. Cammack, Alexandra C.N. Kingston, Ahmed A. Alshareef, Tarek Shazly, Daniel Isaac Speiser
Faculty Publications
Snapping shrimp damp the shock waves they produce and use as weapons with a helmet-like structure termed the orbital hood. Here, we ask how structural and material properties contribute to shock wave damping by orbital hoods in Alpheus heterochaelis. Using tensile mechanical testing, we find orbital hoods are approximately half as stiff as carapace and have twice the capacity for viscous energy dissipation. Microstructural features probably contribute to tissue-specific mechanical properties: the endocuticles of orbital hoods have almost twice as many lamellae as those of carapaces despite being half as thick, suggesting a mechanism for enhanced material mobility underlying …
Developments Of New Metal-Free Batteries And Self-Charging Batteries For Sustainability, Abhishek Paudel
Developments Of New Metal-Free Batteries And Self-Charging Batteries For Sustainability, Abhishek Paudel
LSU Doctoral Dissertations
The growing concerns over the limitations and environmental impact of conventional lithium-ion batteries (LIBs) have driven the search for more sustainable energy storage solutions. Metal-free batteries, such as those utilizing ammonium ions (NH₄⁺), offer a compelling alternative due to their non-toxic nature, abundant availability, and unique electrochemical properties. The NH₄⁺ ion's lower molar mass and distinct tetrahedral structure enable efficient charge transfer and intercalation, distinguishing it from traditional metal ions and potentially improving battery performance. Self-charging batteries, which integrate piezoelectric materials to harvest ambient mechanical energy, present a significant advancement in energy storage technology. By capturing and converting mechanical energy …
Data Management Plans For Grant Proposals, Rubab Shahzad
Data Management Plans For Grant Proposals, Rubab Shahzad
Day Family Research Lab Workshop Series
Fundamentals of research data management and how to create effective Data Management Plans (DMPs) and Data Management Sharing Plans (DMSP)
Cationic Poly(Glucosamine)-Based Polymers Bind To Glycans With Varying Affinity Facilitating Transport Across The Glycocalyx Of Endothelial Cells, Claire Bridges, Lu Fu, Dan Wang, James D. Sterling, Susanna Liang, Shenda M. Baker, Jonathan Yeow, Megan S. Lord
Cationic Poly(Glucosamine)-Based Polymers Bind To Glycans With Varying Affinity Facilitating Transport Across The Glycocalyx Of Endothelial Cells, Claire Bridges, Lu Fu, Dan Wang, James D. Sterling, Susanna Liang, Shenda M. Baker, Jonathan Yeow, Megan S. Lord
Business and Information Technology Faculty Research & Creative Works
Natural polysaccharides, such as chitosan, offer promising avenues for drug delivery due to their cytocompatibility and ability to interact with cell surfaces. However, the endothelial glycocalyx, a glycan-rich extracellular matrix, presents a barrier that must be navigated for effective intracellular delivery. This study investigates how cationic poly(glucosamine)-based polymers, functionalized with guanidinium or ammonium groups, interact with key glycocalyx components including hyaluronan (HA) and heparan sulfate (HS). We demonstrate that these cationic polymers form tunable biomolecular condensates with glycans, with stronger binding observed for sulfated glycans, HS and heparin, than unsulfated HA. Derivatized chitosan polymers with varied cationic side chains exhibit …
Design And Economic Assessment Of A Sustainable Standalone Photovoltaic System For Hospital Lift Applications, Tasneem M. Abed, Saad S. Eskander, Mohamed A. Elsayes, Mohamed Zaki
Design And Economic Assessment Of A Sustainable Standalone Photovoltaic System For Hospital Lift Applications, Tasneem M. Abed, Saad S. Eskander, Mohamed A. Elsayes, Mohamed Zaki
Mansoura Engineering Journal
This study presents an optimized design and operation strategy for a stand-alone solar photovoltaic power system to drive a 4.5 kW elevator at Mansoura University Hospital, Egypt. The research aims to reduce the battery bank capacity and overall system cost while maximizing the utilization of solar panels. A novel "Optimum Operator System" is proposed, incorporating three power switches controlled by an Arduino microcontroller. The system's performance is analyzed through extensive modeling, simulation, and experimental validation. Results show a significant reduction in battery bank capacity, with 7 fewer 100 Ah batteries required compared to conventional systems. The proposed method significantly enhances …
Hyaluronan 35 Prevents Endotoxin-Mediated Dysregulated Skeletal Muscle Proteostasis During Ethanol Exposure, Nicole Welch, Pugazhendhi Kannan, Gangarao Davuluri, Annette Bellar, Amy H. Attaway, Saurabh Mishra, Jasmin A. Cunningham, Avinash Kumar, Ryan Musich, Elif G. Ertugral, Vandana Agrawal, Isaac L. Hu, Terri J. Hartford, Noah L. Weisleder, Vidula T. Vachharajani, Chandrasekhar R. Kothapalli
Hyaluronan 35 Prevents Endotoxin-Mediated Dysregulated Skeletal Muscle Proteostasis During Ethanol Exposure, Nicole Welch, Pugazhendhi Kannan, Gangarao Davuluri, Annette Bellar, Amy H. Attaway, Saurabh Mishra, Jasmin A. Cunningham, Avinash Kumar, Ryan Musich, Elif G. Ertugral, Vandana Agrawal, Isaac L. Hu, Terri J. Hartford, Noah L. Weisleder, Vidula T. Vachharajani, Chandrasekhar R. Kothapalli
Chemical & Biomedical Engineering Faculty Publications
Sarcopenia in alcohol-related liver disease (ALD) is of high clinical significance, but there are no effective treatments. Hyaluronan 35 kDa (HA35), a glycosaminoglycan polymer, modulates responses to Toll-like receptor 4 (TLR4), a lipopolysaccharide receptor, to improve hepatic and macrophage function in ALD. We evaluated skeletal muscle responses to HA35 in preclinical models of ALD. Responses to ethanol, lipopolysaccharide (LPS), and HA35 were studied in differentiated murine C2C12/human-induced pluripotent stem cell (hiPSC)-derived myotubes, and wild-type/HA receptor CD44 knockout (CD44(-/-)) mouse models of ALD (mALD). Signaling molecules and measures of protein homeostasis (proteostasis) were quantified by immunoblots, mitochondrial oxidative function was determined …
Diverse Enteric Bacterial, Viral, And Parasitic Pathogen Genes Are Shed In Animal Feces In Indiana, Anna A. Heintzman, Ishi Keenum, Drew Capone
Diverse Enteric Bacterial, Viral, And Parasitic Pathogen Genes Are Shed In Animal Feces In Indiana, Anna A. Heintzman, Ishi Keenum, Drew Capone
Michigan Tech Publications
Southern Indiana has intensive livestock production, yet species-resolved fecal pathogen and pathogen associated gene profiles are limited. At 10 sites in southern Indiana (April-June 2024), we collected 128 fecal specimens from 10 hosts: pigs (n=12), horses (12), cats (12), chickens (12), dogs (22), white-tailed deer (12), sheep (12), goats (12), cows (12), and humans (10). We extracted and assayed total nucleic acids using a custom 43-target TaqMan Array Card (RT-qPCR). Flotation microscopy was performed on pig and dog stools for helminth ova. In-silico specificity checks were conducted for selected targets due to potential for cross reactivity between pathogen species. Most …
Electromagnetic Simulations For Vulnerable Road User Safety In 5g/6g Wireless Systems, Colin Mcnerny
Electromagnetic Simulations For Vulnerable Road User Safety In 5g/6g Wireless Systems, Colin Mcnerny
Theses and Dissertations
Protecting vulnerable road users is imperative. As 5G wireless technology matures and 6G standards are established, new operational technology emerges to reduce traffic accidents. There is widespread evidence to support the need for pedestrian awareness in modern traffic ecosystems as a significant number of vulnerable road users are injured or killed every year due to observable traffic failures. Computational electromagnetic (CEM) solvers are used to model, simulate, and analyze the performance of antennas deployed to meet this challenge. Validation studies using the Altair FEKO CEM solver demonstrate scenarios where vulnerable road users are at risk. The simulation data in this …
Bulk Absorber Acoustic Characterization Via The Two-Cavity Impedance Tube Methoda), Anthony Ciletti, Janith Godakawela, Martha Brown, Bhisham Sharma
Bulk Absorber Acoustic Characterization Via The Two-Cavity Impedance Tube Methoda), Anthony Ciletti, Janith Godakawela, Martha Brown, Bhisham Sharma
Michigan Tech Publications
The primary goal of this study is to investigate and refine the two-cavity impedance tube method for acoustic characterization of bulk porous materials, specifically addressing previously unexplained inaccuracies in the prediction of surface impedance and absorption coefficients. Unlike the conventional two-thickness approach, the two-cavity method requires only one sample thickness and involves conducting measurements at various air cavity depths behind the sample. The initial analyses revealed previously unidentified numerical instabilities, resulting in anomalous predictions of sound absorption at specific frequencies. Through systematic investigation and use of calculated data, the numerical origins of these anomalies are uncovered and a practical solution, …
Green Technology: A Systematic Review Of Ai And Iot Solutions For A Sustainable Future, Nesma Abd El-Mawla, Mohamed A. Berbar, Nawal A. El-Fishawy, Mohamed A. El-Rashidy, Mahmoud Badawy
Green Technology: A Systematic Review Of Ai And Iot Solutions For A Sustainable Future, Nesma Abd El-Mawla, Mohamed A. Berbar, Nawal A. El-Fishawy, Mohamed A. El-Rashidy, Mahmoud Badawy
Mansoura Engineering Journal
Green technology offers a solution to the pressing environmental crisis. It can change the structure and generation of waste so as not to harm the earth, and people can become environmentally friendly. To address complex environmental challenges like climate change and pollution, innovative Artificial Intelligence (A.I.) and Internet of Things (IoT) solutions are essential. These technologies can help optimize resource use, reduce waste, and promote sustainable development. However, it's crucial to balance economic growth, social equity, and environmental protection when implementing green technologies. This survey paper systematically examines the landscape of Green Technology, focusing on its pivotal components: Measures of …
Challenges And Opportunities In Lentivirus Viral Vector Manufacturing For In Vivo Applications, Eduardo Barbieri, Caryn Heldt
Challenges And Opportunities In Lentivirus Viral Vector Manufacturing For In Vivo Applications, Eduardo Barbieri, Caryn Heldt
Michigan Tech Publications
The clinical success of chimeric antigen receptor (CAR) T-cell therapies has revolutionized oncology, yet the high costs and logistical complexities of ex vivo manufacturing remain significant barriers to global patient access. In vivo cell therapy, which involves the direct injection of lentiviral vectors (LVVs) to engineer cells within the patient’s body, offers a promising, cost-effective alternative. However, transitioning from ex vivo to in vivo applications necessitates a fundamental shift in LVV biomanufacturing to ensure safety and efficacy. This paper examines the critical bottlenecks in the current LVV production landscape. In upstream processing, we explore LVV particle assembly and maturation mechanisms, …
Cellular Therapy For The Treatment Of Ischemic Limb Disease, Akazha Nicole Green
Cellular Therapy For The Treatment Of Ischemic Limb Disease, Akazha Nicole Green
ETDs from 2020-2029
Ischemic limb disease continues to pose major clinical challenges. The effect of this disease causes restricted blood flow, which is followed by a limited ability to regenerate in the vascular tissues. The purpose of this study is to address the current limitations in producing large-scale generation of Smooth Muscle Cells (SMCs) derived from human induced pluripotent stem cells (hiPSCs) and then assessing their potential therapeutic efficiency individually and in combination with endothelial cells (ECs) for vascular repair. A dynamic three-dimensional (3D) culture system was integrated with a two- dimensional (2D) expansion to enhance cell culture yield while maintaining contractile marker …
Patient‐Specific Computational Flow Simulation Reveals Adverse Hemodynamic Factors Associated With Occlusion Of Directional Branches After Fenestrated‐Branched Endovascular Aneurysm Repair, Kenneth Tran, Jesse Chait, Emmanuel Tenorio, Weiguang Yang, Alison Marsden, Bernardo Mendes, Jason T. Lee, Gustavo S. Oderich
Patient‐Specific Computational Flow Simulation Reveals Adverse Hemodynamic Factors Associated With Occlusion Of Directional Branches After Fenestrated‐Branched Endovascular Aneurysm Repair, Kenneth Tran, Jesse Chait, Emmanuel Tenorio, Weiguang Yang, Alison Marsden, Bernardo Mendes, Jason T. Lee, Gustavo S. Oderich
Mechanical Engineering Faculty Publications
Background: Fenestrated and branched endovascular aneurysm repair can be complicated by branch vessel occlusion in the absence of structural stenosis. We hypothesized that computational flow simulation could identify adverse hemodynamic features associated with postfenestrated and branched endovascular aneurysm repair branch occlusion.
Methods: Patients undergoing 4-vessel fenestrated and branched endovascular aneurysm repair for Extent II to IV thoracoabdominal aortic aneurysms were retrospectively reviewed. Branches that occluded without identifiable kinking or stenosis on computed tomography were included, along with an equal cohort of anatomy-matched patent controls. Patient-specific pulsatile rigid-wall simulations were performed using SimVascular with individualized geometries and boundary conditions. Abnormal time-averaged …