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Everyone Brings Something To The Table: A Culturally Sustaining Analysis Of Teacher Candidates’ Mixed Reality Teaching Simulations, Erin Scott Dec 2024

Everyone Brings Something To The Table: A Culturally Sustaining Analysis Of Teacher Candidates’ Mixed Reality Teaching Simulations, Erin Scott

Faculty Publications

Discussions of HBCU students’ content knowledge have centered around developing high impact, asset-based approaches to learning (Williams et al, 2022). So, HBCU teacher preparation providers (TPPs) can also focus efforts on culturally sustaining approaches to developing candidates’ content knowledge and researching how high impact practices, like teaching simulations, can help prepare candidates for classrooms. This exploratory case study uses critical cases (n=2); findings suggest candidates have a developing understanding of content, which forms a solid basis for increasing their knowledge. MRTSs are addressed as a potential high impact, culturally sustaining practice for building candidates’ content knowledge. Further, HBCU TPPs can …


Multi-Scale Modeling Of Dna-Templated Aggregates For Excitonic Applications, German Barcenas Moncada Dec 2024

Multi-Scale Modeling Of Dna-Templated Aggregates For Excitonic Applications, German Barcenas Moncada

Boise State University Theses and Dissertations

Quantum entanglement occupies a central role in the application of quantum mechanics towards emerging technologies of quantum information systems. Meanwhile, quantum entanglement is believed to be observed at room temperature in photosynthetic complexes in plants and algae through the energy transfer of dye molecules. The goal of this project is to engineer dye properties and their arrangement when dyes and aggregates are covalently attached to DNA so that the emergent property of exciton delocalization is as coherent, predictable, detectable and controllable. The creation of such a platform would enable the continued study of near room-temperature quantum entanglement and the more …


Designing An Advanced Gui For A Laser Harp, Matthew Moran Dec 2024

Designing An Advanced Gui For A Laser Harp, Matthew Moran

2024 Fall Honors Capstone Projects - Archive

This project presents the design and development of a laser harp, an innovative digital instrument that combines music and technology to inspire interest in STEM education. The harp uses laser beams and phototransistors to simulate the strings of a traditional harp, producing sound when the beams are interrupted. The primary focus of the honors section of this work is a custom-built software interface developed with a graphical user interface (GUI) that allows users to easily adjust settings like note range, volume, and the central part of the show, looping notes. The GUI is designed to be intuitive, making it easy …


Exploring Smart Thermostat, Don P. Dang Dec 2024

Exploring Smart Thermostat, Don P. Dang

2024 Fall Honors Capstone Projects - Archive

This study examines the security, privacy, and compatibility challenges associated with smart thermostats in smart home systems. Smart thermostats, as part of the growing Internet of Things (IoT) ecosystem, face vulnerabilities such as unauthorized access, data breaches, and inconsistent security protocols. Using a mixed-methods approach, this research evaluates encryption techniques, communication protocols (Zigbee, Z-Wave, Wi Fi), and user behaviors that impact system security and efficiency. Key findings indicate that 35% of users are concerned about hacking risks, while 25% express data privacy concerns. Many users lack awareness of security measures, such as firmware updates and password management, which increases vulnerabilities. …


A Machine-Learning Approach To Predicting The Achievement Of Australian Students Using School Climate; Learner Characteristics; And Economic, Social, And Cultural Status, Myint S. Khine, Yang Liu, Vivek K. Pallipuram, Ernest Afari Dec 2024

A Machine-Learning Approach To Predicting The Achievement Of Australian Students Using School Climate; Learner Characteristics; And Economic, Social, And Cultural Status, Myint S. Khine, Yang Liu, Vivek K. Pallipuram, Ernest Afari

Pacific Faculty Work

The Programme for International Student Assessment (PISA) is a global survey conducted by the Organisation for Economic Co-operation and Development (OECD) to assess educational systems by evaluating the academic performance of 15-year-old school students in mathematics, science, and reading. In PISA 2022, 13,437 students from Australia participated in the test. While the PISA main questionnaire assesses the subject knowledge, the student background questionnaire solicits contextual information such as school climate, learner characteristics, and socioeconomic status. This study analyses how these contextual variables predict student achievement using the machine-learning models Ridge Linear Regression, K-Nearest Neighbours, Decision Trees, eXtreme Gradient Boosting, and …


Ellipticity-Controlled Exceptional Points From Nanoscale Metasurfaces, Benjamin Goldberg Dec 2024

Ellipticity-Controlled Exceptional Points From Nanoscale Metasurfaces, Benjamin Goldberg

McKelvey School of Engineering Graduate Student Theses & Dissertations

Precise control over light polarization is critical for advancing technologies in telecommunica- tions, quantum computing, and image sensing. However, existing methods for manipulating polarization around exceptional points in non-Hermitian systems, have exclusively focused on circular polarization and work with reflected light. To address this limitation, we de- velop a novel metasurface platform with high-Q resonators that enables tunable control of polarization exceptional points across arbitrary ellipticity for transmitted light. Our design uses orthogonally polarized guided mode resonators in a two-layer silicon metasurface, where careful tuning of the dipolar guided mode resonances (DGMRs) and layer spacing allows us to control the …


Impact Of Irrigation Systems On Water Use And Water Productivity: A Case Study Using Aquacrop In Khartoum, Sudan, Abdalhakam Almagzoop Dec 2024

Impact Of Irrigation Systems On Water Use And Water Productivity: A Case Study Using Aquacrop In Khartoum, Sudan, Abdalhakam Almagzoop

Department of Agricultural and Biological Systems Engineering: Masters Project Reports

Water scarcity significantly challenges agricultural productivity in arid regions like Khartoum, Sudan. This study evaluates the impact of three irrigation systems—furrow, sprinkler, and surface drip—on the water use and productivity of sorghum (Sorghum bicolor L.) under different climatic conditions using the AquaCrop model. Simulations were conducted for three representative years: a wet year (2022), a normal year (2015), and a dry year (2018). The results demonstrate that irrigation substantially improved water use efficiency and crop yield compared to non-irrigated (rainfed) conditions. Rainfed crops resulted in lower biomass, harvest index, and yield, particularly in the dry year, highlighting the importance …


Enhancing Water Sustainability In North Africa: Literature Review And Synthesis Of Current Knowledge Gaps In Sudan, Osman M. A. Adam Dec 2024

Enhancing Water Sustainability In North Africa: Literature Review And Synthesis Of Current Knowledge Gaps In Sudan, Osman M. A. Adam

Department of Agricultural and Biological Systems Engineering: Masters Project Reports

This study delves into the critical role of groundwater in addressing global water challenges, with a focus on the Nubian Sandstone Aquifer System (NSAS) in north Africa. Groundwater constitutes a source of potable water, irrigation, and industrial use, especially in arid regions where surface water is limited. We analyzed the status of water quantity, withdrawals, recharge, and geological characteristics in the NSAS, specifically in Sudan, Egypt, and Libya. Though the NSAS is largely an untapped resource, water withdrawals from the NSAS in Egypt, Sudan, and Libya are projected to increase substantially from 2000 to 2100 due to population growth, with …


Toward Electrochemical Detection Of Salmonella Enterica Serovar Enteritidis On Hydroponically Grown Green Onions (Allium Fistulosum L.), Lisseth Casso-Hartmann Dec 2024

Toward Electrochemical Detection Of Salmonella Enterica Serovar Enteritidis On Hydroponically Grown Green Onions (Allium Fistulosum L.), Lisseth Casso-Hartmann

All Theses

The Food and Drug Administration (FDA) established standards during the growing, harvesting, packing, and holding of produce for human consumption as part of implementing the Food Safety Modernization Act (FSMA). One of the main requirements for farmers is to detect environmental pathogens such as Salmonella enterica species in water and sprout samples. S. enterica is a bacterium of significant concern due to its pathogenicity and ability to survive and persist in diverse environmental conditions. S. enterica has been associated with recalls in ready-to-eat foods. Traditional detection methods include Enzyme-Linked Immunosorbent Assay (ELISA), Polymerase Chain Reaction (PCR), and plate counting, which …


The Effect Of Pressure Gradients On Perceived Discomfort, Zachary Bush Dec 2024

The Effect Of Pressure Gradients On Perceived Discomfort, Zachary Bush

All Theses

Introduction:

A pressure gradient is where high and low pressure meet. It is responsible for displacement and irritation of the skin commonly caused by tight bandages, bracelets, or socks. The irritation is at the edge where the skin is displaced by the high and low pressure. An analysis of the effect pressure gradients have on discomfort would have significant medical relevance for any device, fixture, or clothing pressed against the skin at high pressure. This primarily includes prosthetic and orthotic devices.

The bottom surface of the heel provides a naturally circular, uniform pressure profile. This makes it the optimal testing …


Multiphysics Modeling And Experimental Validation Of High-Strength Steel In Laser Powder Bed Fusion Process, M. Rangapuram, S. Babalola, J. W. Newkirk, L. N. Bartlett, F. W. Liou, K. Chandrashekhara, Stephen R. Cluff Dec 2024

Multiphysics Modeling And Experimental Validation Of High-Strength Steel In Laser Powder Bed Fusion Process, M. Rangapuram, S. Babalola, J. W. Newkirk, L. N. Bartlett, F. W. Liou, K. Chandrashekhara, Stephen R. Cluff

Materials Science and Engineering Faculty Research & Creative Works

Laser powder bed fusion (LPBF) is a subset of the additive manufacturing process in which a laser beam selectively joins the metal powder into a desired part in a sequential layer process. Owing to its complex nature of rapid heating and cooling of the melt pool, there is a need to understand the melt pool behavior and its effects on the final manufactured part. a densely packed powder bed is highly desirable for fabricating a superior part using the LPBF process. in this work, discrete element model was used to generate powder beds with realistic powder properties and various factors …


Alteration Of Peripheral Cytokines In Alzheimer’S Disease, Zhengshi Yang Dec 2024

Alteration Of Peripheral Cytokines In Alzheimer’S Disease, Zhengshi Yang

UNLV Theses, Dissertations, Professional Papers, and Capstones

Alzheimer’s disease (AD) is a progressive neurodegenerative disease with the clinical symptoms of gradual cognitive decline and memory loss. Biologically, abnormal accumulation of Aβ (Aβ) plaque and tau tangles in the brain are the core pathological hallmarks in AD. Although inflammatory response is not specific to AD, emerging evidence suggests that the disrupted innate immune system within the central nervous system, particularly microglial activation, might act as the bridge linking Aβ aggregation to pathological phosphorylation and aggregation of tau. The inflammatory response was suggested to initially have a neuroprotective role of attempting to clear Aβ plaques, and then become neurotoxic …


Nlp-Based Quantitative Methods For Measuring Highway Project Similarity To Support Project Clustering And Bundling, Quan Do Dec 2024

Nlp-Based Quantitative Methods For Measuring Highway Project Similarity To Support Project Clustering And Bundling, Quan Do

All Dissertations

State highway agencies (SHAs) often need to classify similar projects into distinct work type clusters, enabling them to correlate new projects with historical data on cost, schedule, pay item production rates, and project complexity. This classification also facilitates the identification of similar projects for project bundling. However, the conventional method for classifying projects into work types is inefficient, relying heavily on subjective judgment and manual review of project scope. This inefficiency hinders SHAs’ ability to effectively apply knowledge gained from historical projects to future projects. Moreover, the subjective nature of project classification is time-consuming and can result in inconsistencies and …


Deep Learning For Bitcoin Price Direction Prediction: Models And Trading Strategies Empirically Compared, Oluwadamilare Omole, David Enke Dec 2024

Deep Learning For Bitcoin Price Direction Prediction: Models And Trading Strategies Empirically Compared, Oluwadamilare Omole, David Enke

Engineering Management and Systems Engineering Faculty Research & Creative Works

This paper applies deep learning models to predict Bitcoin price directions and the subsequent profitability of trading strategies based on these predictions. The study compares the performance of the convolutional neural network–long short-term memory (CNN–LSTM), long- and short-term time-series network, temporal convolutional network, and ARIMA (benchmark) models for predicting Bitcoin prices using on-chain data. Feature-selection methods—i.e., Boruta, genetic algorithm, and light gradient boosting machine—are applied to address the curse of dimensionality that could result from a large feature set. Results indicate that combining Boruta feature selection with the CNN–LSTM model consistently outperforms other combinations, achieving an accuracy of 82.44%. Three …


Geochemical Evidence Of Drying During The 4.2 Ka Event In Sediment Cores From The Yucatán Peninsula, Mexico, Derek K. Gibson, Jonathan Obrist-Farner, Alex Correa-Metrio, Alejandra Rodriguez-Abaunza, Carlos Castañeda-Posadas Dec 2024

Geochemical Evidence Of Drying During The 4.2 Ka Event In Sediment Cores From The Yucatán Peninsula, Mexico, Derek K. Gibson, Jonathan Obrist-Farner, Alex Correa-Metrio, Alejandra Rodriguez-Abaunza, Carlos Castañeda-Posadas

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Tropical hydroclimate variability during the Middle and Late Holocene was investigated using geochemical indicators of local-scale precipitation and evaporation preserved in sediment cores from two sites in the Mexican Yucatán Peninsula. Scanning X-Ray fluorescence spectroscopy data show generally decreasing precipitation trends during the Early and Middle Holocene. During the transition between the Middle and Late Holocene, geochemical evidence of reduced watershed erosion and increased evaporation indicate that a centennial-scale drying event impacted the region between 4.3 and 4.0 ka (kilo-anum; thousand years before present). These findings suggest that the 4.2 ka drying event, which has been previously recorded in Europe, …


A Strategic Insight Into The Market For Carbon Management Capacity, Mahelet G. Fikru, Ting Shen, Jennifer Brodmann, Hongyan Ma Dec 2024

A Strategic Insight Into The Market For Carbon Management Capacity, Mahelet G. Fikru, Ting Shen, Jennifer Brodmann, Hongyan Ma

Economics Faculty Research & Creative Works

This study presents the market for carbon management capacity via carbon capture, utilization, and storage technologies, identifying demand and supply forces, as well as clarifying the potential impact of market and non-market-based shocks on technology developers versus adopters. The paper addresses a prevailing gap in market analysis, introducing a microeconomic framework and unique dataset to identify key players, market forces, and policy incentives shaping the carbon capture, utilization, and storage landscape. The analysis equips industry stakeholders, policymakers, and investors with valuable insights regarding (1) leaders in the design, development, and manufacture of carbon capture, utilization, and storage technologies (supply), (2) …


Development Of Uranium Fluoride Microstructures, Harry Jang Dec 2024

Development Of Uranium Fluoride Microstructures, Harry Jang

UNLV Theses, Dissertations, Professional Papers, and Capstones

Uranium microstructured materials with controlled size and shape have found applications in several branches of the nuclear industry including as targets for medical isotopes production, fuels for nuclear reactors, standards for analytical measurements, and energy sources for space exploration. Morphological studies of actinide materials are also highly relevant to nuclear forensics-related work. Other potential applications include information storage, catalysis, sensors, and luminescent devices. Most studies on uranium microstructured materials have focused on binary oxides, nitrides, carbides, and fluorides, with the spherical shape being the dominant morphology. Prior to the work reported in this dissertation, aside from UF4 microspheres (ms) and …


Investigation Ionic Polymer Metal Composite Capacitors Through Fabrication, Experimentation, And Modeling, Liya S. Napollion Dec 2024

Investigation Ionic Polymer Metal Composite Capacitors Through Fabrication, Experimentation, And Modeling, Liya S. Napollion

UNLV Theses, Dissertations, Professional Papers, and Capstones

The increasing demand for greater energy storage capacity alongside the need to minimize the size of various devices, such as hybrid electric vehicles, medical devices, and pulsed power systems—has highlighted the necessity for advanced polymer film capacitors with high energy density. While traditional batteries and electronic devices have generally sufficed for many applications, their inherent size limitations hinder their ability to deliver the high levels of peak power required for certain demanding applications. This shortfall highlights the critical ongoing challenge within the energy storage sector to improve technology and more effectively meet these growing power requirements. Flexible Ionic Polymer Metal …


Fast Neutron & Gamma-Ray Scintillation And Broadband Photoluminescence From Gallium Nitride & Gallium Oxide: Developing Radiation-Hard Diagnostic Platforms, Daniel Jesus Valdes Dec 2024

Fast Neutron & Gamma-Ray Scintillation And Broadband Photoluminescence From Gallium Nitride & Gallium Oxide: Developing Radiation-Hard Diagnostic Platforms, Daniel Jesus Valdes

UNLV Theses, Dissertations, Professional Papers, and Capstones

Integrated scintillation and electronics processing materials are of critical importance in environments exposed to high levels of radiation, such as nuclear fusion diagnostics and space missions. This dissertation focuses on the radiation detection capabilities of gallium oxide (Ga2O3) and gallium nitride (GaN), exploring their responses to fast neutrons and gamma rays. Using high-energy neutron beam facilities at Los Alamos Neutron Science Center (LANSCE) Flight Path 4FP60R, we exposed both Ga2O3 and GaN crystals to neutron irradiation spanning an energy spectrum ranging from 1 to 400 MeV. A Pi-Max 4 fast-gated Intensified CCD (ICCD) camera captured the transient scintillation responses for …


Introducing The Second-Order Features Adjoint Sensitivity Analysis Methodology For Neural Ordinary Differential Equations—I: Mathematical Framework, Dan Gabriel Cacuci Dec 2024

Introducing The Second-Order Features Adjoint Sensitivity Analysis Methodology For Neural Ordinary Differential Equations—I: Mathematical Framework, Dan Gabriel Cacuci

Faculty Publications

This work introduces the mathematical framework of the novel “First-Order Features Adjoint Sensitivity Analysis Methodology for Neural Ordinary Differential Equations” (1st-FASAM-NODE). The 1st-FASAM-NODE methodology produces and computes most efficiently the exact expressions of all of the first-order sensitivities of NODE-decoder responses with respect to the parameters underlying the NODE’s decoder, hidden layers, and encoder, after having optimized the NODE-net to represent the physical system under consideration. Building on the 1st-FASAM-NODE, this work subsequently introduces the mathematical framework of the novel “Second-Order Features Adjoint Sensitivity Analysis Methodology for Neural Ordinary Differential Equations (2nd-FASAM-NODE)”. The 2nd-FASAM-NODE methodology efficiently computes the exact expressions …


Thermal Conductivity Characterization Of High Oleic Vegetable Oils Based Hybrid Nanofluids Formulated Using Gnp, Tio2, Mos2, Al2o3 Nanoparticles For Mql Machining, Anthony Chukwujekwu Okafor, Tobechukwu Kingsley Abor, Saidanvar Esanjonovich Valiev, Ignatius Echezona Ekengwu, Abiodun Saka, Monday Uchenna Okoronkwo Dec 2024

Thermal Conductivity Characterization Of High Oleic Vegetable Oils Based Hybrid Nanofluids Formulated Using Gnp, Tio2, Mos2, Al2o3 Nanoparticles For Mql Machining, Anthony Chukwujekwu Okafor, Tobechukwu Kingsley Abor, Saidanvar Esanjonovich Valiev, Ignatius Echezona Ekengwu, Abiodun Saka, Monday Uchenna Okoronkwo

Mechanical and Aerospace Engineering Faculty Research & Creative Works

This paper presents the results of thermal conductivity characterization of six high oleic soybean oil (HOSO) and four high oleic canola oil (HOCO)-based hybrid nanofluids formulated with four types of nanoparticles (Graphene nanoplatelet (xGnP), TiO2, MoS2, and Al2O3) at nanoparticles wt.% concentration from 1 % to 7 % in 1 % increment using the two-step method for use in MQL machining of difficult-to-cut metals. Thermal conductivity of the formulated hybrid nanofluids were measured using Thermtest Transient Hot Wire Liquid Thermal Conductivity Meter at temperatures from 25 °C to 75 °C in increment of 10 °C. Obtained results showed that thermal …


Experimental Evaluation Of A Recrosslinkable Co2-Resistant Micro-Sized Preformed Particle Gel For Co2 Sweep Efficiency Improvement In Reservoirs With Super-K Channels, Adel Alotibi, Tao Song, Ali Al Brahim, Baojun Bai, Thomas P. Schuman Dec 2024

Experimental Evaluation Of A Recrosslinkable Co2-Resistant Micro-Sized Preformed Particle Gel For Co2 Sweep Efficiency Improvement In Reservoirs With Super-K Channels, Adel Alotibi, Tao Song, Ali Al Brahim, Baojun Bai, Thomas P. Schuman

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

A recross linkable CO2-resistant branched preformed particle gel (CO2-BRPPG) was developed for controlling CO2 injection conformance, particularly in reservoirs with super-permeable channels. Previous work focused on a millimeter-sized CO2-BRPPG in open fractures, but its performance in high-permeability channels with pore throat networks remained unexplored. This study used a sand pack model to evaluate a micro-sized CO2-BRPPG under varying conditions of salinity, gel concentration, and pH. at ambient conditions, the equilibrium swelling ratio (ESR) of the gel reached 76 times its original size. This ratio decreased with increasing salinity but remained stable …


Fitting Quality Of Nmr Relaxation Data To Differentiate Asphalt Binders, Rebecca M. Herndon, Kevin Lai, Magdy Abdelrahman, Klaus Woelk Dec 2024

Fitting Quality Of Nmr Relaxation Data To Differentiate Asphalt Binders, Rebecca M. Herndon, Kevin Lai, Magdy Abdelrahman, Klaus Woelk

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Asphalt binder performance grades (PGs) are important metrics in designing pavements for effective transportation infrastructure. the PG system relies on the binder's stiffness and is determined through energy- and time-intensive physical testing. Physical properties, like stiffness, can also be determined by spin–lattice NMR relaxometry, a non-destructive chemical method. NMR relaxometry can quantify the molecular mobility of materials by determining relaxation times from exponential decays of excited nuclear magnetization. While relaxation times have been used to determine physical properties of materials, a quantitative relation to the PG grades of asphalt binder is yet to be established. in this study, T1 NMR …


Argument Schema Of Undergraduate Engineering Students, Anu Singh Dec 2024

Argument Schema Of Undergraduate Engineering Students, Anu Singh

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Critical thinking is one of the most desired skills in the workplace, as it assists an individual in solving complex problems and making informed decisions, resulting in their workplace success. Argumentation is one instructional approach that provides students an opportunity to engage in higher-order thinking and improve their communication skills. Argumentative writing provides opportunities to engage in multiple perspectives of a problem, provide evidence for the claim, evaluate evidence, engage in reasoning, and acknowledge self-bias, which automatically engages students in critical thinking. Previous literature has shown that despite the use of interventions and scaffolding approaches, students' argumentative texts lack elements …


Characterizing Locust Anemotaxis: The Impact Of Sensory Perturbations On Flight Behavior, Yi-Xiao Huang Dec 2024

Characterizing Locust Anemotaxis: The Impact Of Sensory Perturbations On Flight Behavior, Yi-Xiao Huang

McKelvey School of Engineering Graduate Student Theses & Dissertations

This thesis investigates the effects of sensory perturbations on locust flight behavior, with the goal of better understanding how locusts integrate multiple sensory inputs to maintain flight control. Through a series of experiments, locusts were subjected to visual impairment, turbulent wind conditions, mechanical impairments of their wings and antennae, and pheromonal interference. These perturbations allowed for the exploration of the contributions each sensory pathway makes to flight stability and navigation in a controlled environment.

Results show that while visual impairment does not significantly impact average flight speed, it increases variability in flight stability, suggesting that visual cues are important for …


Human-Aware Motion Planning For Aerial Robots, Beichen Zhou Dec 2024

Human-Aware Motion Planning For Aerial Robots, Beichen Zhou

McKelvey School of Engineering Graduate Student Theses & Dissertations

This project shows a combination for drones autonomous navigation in dynamic environments. The algorithm combine Social GAN SGAN for human trajectory prediction with Rapidly-exploring Random Tree Star RRT* for path planning. The objective is to efficiently and safe navigate in the area with human. Drones would avoid moving human and maintaining optimal flight path. During training SGAN model, we use both public datasets and dataset collected in the lab, which improve its adaptability in the lab. This experiment was tested through simulations and real-word experiment. SGAN provided a good prediction of human trajectories, which help drones to adjust their path. …


Type Ii Innate Lymphoid Cell Plasticity Contributes To Impaired Reconstitution After Allogeneic Hematopoietic Stem Cell Transplantation, Sonia J. Laurie, Joseph P. Foster, Danny W. Bruce, Hemamalini Bommiasamy, Oleg V. Kolupaev, Mostafa Yazdimamaghani, Samantha G. Pattenden, Nelson J. Chao, Stefanie Sarantopoulos, Joel S. Parker, Ian J. Davis, Jonathan S. Serody Dec 2024

Type Ii Innate Lymphoid Cell Plasticity Contributes To Impaired Reconstitution After Allogeneic Hematopoietic Stem Cell Transplantation, Sonia J. Laurie, Joseph P. Foster, Danny W. Bruce, Hemamalini Bommiasamy, Oleg V. Kolupaev, Mostafa Yazdimamaghani, Samantha G. Pattenden, Nelson J. Chao, Stefanie Sarantopoulos, Joel S. Parker, Ian J. Davis, Jonathan S. Serody

Chemical and Biochemical Engineering Faculty Research & Creative Works

Type II innate lymphoid cells (ILC2s) maintain homeostasis and barrier integrity in mucosal tissues. In both mice and humans, ILC2s poorly reconstitute after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Determining the mechanisms involved in their impaired reconstitution could improve transplant outcomes. By integrating single-cell chromatin and transcriptomic analyses of transplanted ILC2s, we identify a previously unreported population of converted ILC1-like cells in the mouse small intestine post-transplant. Exposure of ILC2s to proinflammatory cytokines resulted in a mixed ILC1-ILC2 phenotype but was able to convert only a small population of ILC2s to ILC1s, which were found post-transplant. Whereas ILC2s protected against …


Delineating Genetic Influences On Neurodegenerative Disorders And Infectious Diseases Through Advanced Computational Methods, Xiaowei Zhuang Dec 2024

Delineating Genetic Influences On Neurodegenerative Disorders And Infectious Diseases Through Advanced Computational Methods, Xiaowei Zhuang

UNLV Theses, Dissertations, Professional Papers, and Capstones

Genetics plays a critical role in understanding the molecular mechanisms underlying neurodegenerative disorders and pathogen evolution in infectious diseases. For example, identifying genetic variants associated with a disease phenotype uncovers functional pathways that could lead to potential drug targets and therapeutic interventions. In addition, tracking the genetic evolution of pathogens enables early detection and warning of infectious disease outbreaks. In both applications, given the large amount of genetic data, advanced computational methods, including longitudinal and multivariate models, could significantly boost the statistical power and capture interrelationships among traits, environmental factors and genetic influences. This dissertation focuses on four applications of …


Density-Driven Investigations Of Ruthenium Binary Compounds Rux2 (X = O, S, N), Melanie White Dec 2024

Density-Driven Investigations Of Ruthenium Binary Compounds Rux2 (X = O, S, N), Melanie White

UNLV Theses, Dissertations, Professional Papers, and Capstones

Exploration and fine-tuning of the energy landscape of materials can be accessed by means of changes in material density, a key principle of high pressure research. Density-driven changes impact variations in oxidation states and coordination numbers for the element constituents of a compound. Pressure-induced modification of intrinsic density can promote the formation of new materials, variations in physical properties, and transformations in crystallographic symmetry. With this as our foundation, we focus on ruthenium binary compounds - altering the anion species to change electronegativity while probing pressure and temperature effects. This led us to the present study of ruthenium oxide RuO2, …


Estimating The Possible Qpos Of M87* From The Parameters Of A Hairy Kerr Black Hole, Orhan Donmez, Fatih Dogan Dec 2024

Estimating The Possible Qpos Of M87* From The Parameters Of A Hairy Kerr Black Hole, Orhan Donmez, Fatih Dogan

Materials Science and Engineering Faculty Research & Creative Works

In this paper, we study the dynamics of the shock cone formed around a hairy Kerr black hole due to Bondi– Hoyle–Lyttleton (BHL) accretion and investigate the quasi-periodic oscillations (QPO) behaviors resulting from the black hole-cone interaction, aiming to predict the QPO frequencies that may occur around the M87∗ black hole. To achieve this, we use the hairy Kerr black hole parameters consistent with the observed shadow parameters of M87∗ as initial conditions in numerical simulations, revealing the structure of the resulting shock cone and QPOs in a strong gravitational field. Numerical calculations show that the deviation of …