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Articles 181 - 210 of 18349
Full-Text Articles in Entire DC Network
A Descriptive Analysis Of Plant Leaf Disease Detection Using Machine Learning And Deep Learning Models: A Systematic Review, Arzoo Chamoli, Anuj Kumar
A Descriptive Analysis Of Plant Leaf Disease Detection Using Machine Learning And Deep Learning Models: A Systematic Review, Arzoo Chamoli, Anuj Kumar
Turkish Journal of Electrical Engineering and Computer Sciences
Plant leaf disease detection (PLDD) is a growing active research area with burgeoning practical applications across various sectors such as agricultural monitoring, food security, and environmental conservation. Accurate segmentation and classification of plant leaf diseases remains a key challenge in the field of plant leaf disease prediction. The challenge demands automated methods for the plant disease identification because it needs to develop better crop management systems, which will boost agricultural production. In this article, we provide a systematic review of various machine learning (ML) and deep learning (DL) methods extensively used for PLDD. The review strategy follows a formal protocol, …
A Review Of Magnesium-Based Stents: Manufacturing Strategies And Future Trends, Amir Motaharinia, Amir Sanati Nezhad, Jeremy Goldman, H. R. Bakhsheshi-Rad, J. Drelich
A Review Of Magnesium-Based Stents: Manufacturing Strategies And Future Trends, Amir Motaharinia, Amir Sanati Nezhad, Jeremy Goldman, H. R. Bakhsheshi-Rad, J. Drelich
Michigan Tech Publications
Coronary artery disease is often treated with vascular stents to restore the blood flow. Recently, there has been growing interest in biodegradable metal stents, especially those made from magnesium (Mg). This review starts by explaining the complex pathophysiology of atherosclerosis and the current treatment options. It then discusses stents, including their potential benefits, capabilities, and limitations, as they represent the gold standard for percutaneous coronary intervention in treating atherosclerosis. Given the vital role of stents, we provide a thorough review of the manufacturing techniques involved, such as wire forming, subtractive manufacturing, and additive manufacturing, with a specific focus on stents …
High-Surface-Area Ficus Leaf-Extracted Cuo-Zno-Nio Ternary Nanocomposites For Rapid Adsorption-Assisted Uv-A Degradation Of Direct Blue 15, Kafa’A H. Ali, Mohammed A. Atiya, Ahmed K. Hassan
High-Surface-Area Ficus Leaf-Extracted Cuo-Zno-Nio Ternary Nanocomposites For Rapid Adsorption-Assisted Uv-A Degradation Of Direct Blue 15, Kafa’A H. Ali, Mohammed A. Atiya, Ahmed K. Hassan
Karbala International Journal of Modern Science
Direct Blue 15 (DB15) is a long-lasting synthetic dye that pollutes water and is difficult to remove during wastewater treatment. Conventional treatments fail to remove DB15 adequately due to rapid electron-hole recombination, which necessitates photocatalysts with reduced recombination rates for effective dye removal. The study aims to synthesize and evaluate a CuO-ZnO-NiO ternary system as an integrated adsorption and UV-A photocatalysis platform for DB15 removal. Ficus leaf-extracted CuO-ZnO-NiO nanocomposites with four Cu:Zn:Ni ratios (1:1:1, 1:1:2, 1:2:1, 2:1:1) were prepared by co-precipitation, followed by extensive chemical and physical characterization and dye-removal performance measurements. The CuO-ZnO-NiO nanocomposite exhibited hexagonal zinc oxide, cubic …
Comprehensive Analysis Of Spray Development And Low Temperature Combustion Characteristics In A Cvcc With Nvh Of Renewable Aerospace Fuels: Hefa & Ft Synthetic Kerosene (S8) Compared To Jet-A & Ulsd, Coleman Norton
Honors College Theses
A comprehensive analysis was conducted to research the viability of Hydroprocessed Esters and Fatty Acids (HEFA) and S8 Synthetic Kerosene fuels as a drop-in replacement for conventional petroleum-based fuels, Jet-A and ULSD (Ultra Low Sulfur Diesel). Global transportation remains heavily dependent on liquid fossil fuels, while renewable aerospace fuels offer a promising pathway to reducing life cycle greenhouse gas emissions and pollution. However, the combustion performance and long-term feasibility of these fuels remain insufficiently characterized. This study performed a thorough assessment of each fuel's thermophysical and combustion properties. Thermophysical characterization encompassed viscosity, freezing point, energy density, spray atomization, and volatility. …
Simulated Intelligence, Surveillance, And Play, Atienah Cape
Simulated Intelligence, Surveillance, And Play, Atienah Cape
Theses - ALL
This MFA thesis explores modern panopticism and the feeling of being watched by creating and installing Four Real Friends, an interactive robotic artwork inspired by the 1998 Furby. The project looks at how surveillance technologies are not just outside forces, but part of daily life, often feeling familiar, playful, and even social. The installation uses hardware design, custom circuits, computer vision, and real-time data display to collect and process how visitors interact in the gallery. Its nostalgic and friendly look encourages people to take part, while still showing how data is collected and displayed as it happens. This makes surveillance …
Symmetries Of Legged Locomotion: Theory And Applications In Animals And Robots, Jiayu Ding
Symmetries Of Legged Locomotion: Theory And Applications In Animals And Robots, Jiayu Ding
Dissertations - ALL
Legged locomotion in animals and robots is naturally modeled as a hybrid dynamical system: smooth body evolution is repeatedly interrupted by discrete contact events such as touchdown and liftoff. Although symmetry is a powerful organizing principle in smooth dynamical systems, a comparably systematic symmetry framework for hybrid legged locomotion remains underdeveloped. This dissertation develops such a framework for a scoped class of periodic hybrid locomotion models and uses it to relate theoretical gait analysis, animal locomotion studies, and robotic gait generation. The dissertation first extends symmetry notions from autonomous dynamics to hybrid legged systems and distinguishes symmetries of the hybrid …
Center For Manufacturing Excellence Capstone Project: Critter Catchers, Wilson R. Eatherly, Sophie C. Smith, Joyce W. Nkanor
Center For Manufacturing Excellence Capstone Project: Critter Catchers, Wilson R. Eatherly, Sophie C. Smith, Joyce W. Nkanor
Honors Theses
The Haley Barbour Center for Manufacturing Excellence annually presents seniors with the opportunity to do a capstone project that encapsulates their skills learned throughout undergraduate coursework. The interdisciplinary teams are made up of engineering, accounting, and business students. These students bring their skill sets together to come up with a business plan for the project they have been placed on. This team, Critter Catchers, chose to manufacture non-lethal animal traps meant to be a safe alternative to traps on the market that may injure animals. The trap was made primarily out of wood and operated by means of a pressure-triggered …
Designing A Collaborative Uav-Ugv System For Autonomous Challenge Completion, Ember Reysen
Designing A Collaborative Uav-Ugv System For Autonomous Challenge Completion, Ember Reysen
Honors Theses
The coordination between Unmanned Aerial Vehicles (UAVs) and Unmanned Ground Vehicles (UGVs) holds significant potential for completing complex tasks such as disaster response and construction surveillance by leveraging the strengths of aerial flight and stable on-ground transportation. Unfortunately, coordination between UAVs and UGVs is extremely complex and task-dependent, leading to limited understanding of autonomous collaboration. This thesis explores the process of designing an UAV-UGV collaborative system capable of aerially scouting a target destination, relaying its coordinates to a ground vehicle, and performing a precision landing for unison travel. I utilize computer vision techniques via OpenCV for target marker identification, ROS …
Waste Wood Biochar As A Potential Agricultural Soil Amendment, Gavin Rahl
Waste Wood Biochar As A Potential Agricultural Soil Amendment, Gavin Rahl
Honors Theses
Biochar, as a technology, has and continues to be evaluated for a wide variety of purposes including drinking water treatment of heavy metals and air filtration for harmful contaminants. When evaluating the logging industry, a problem has emerged around residual wood waste (slash piles) in the field that biochar production may be able to address. Additionally, agriculture has begun to look for alternatives to nitrate heavy fertilizers that can cause eutrophication in waterways that biochar has the potential to address. In this study, the effect of biochar addition was assessed in agricultural fields with tight margin alfalfa/grass hay crops to …
Lessons Learned: Commissioning An Fgd Wastewater Treatment System, Bella Triolet, Mckale Grant, Louis Manigault
Lessons Learned: Commissioning An Fgd Wastewater Treatment System, Bella Triolet, Mckale Grant, Louis Manigault
World of Coal Ash Proceedings
Stantec recently supported commissioning a flue gas desulfurization (FGD) Wastewater Treatment System in accordance with the 2020 Environmental Protection Agency (EPA) Effluent Limitations Guidelines (ELG) Rule, which requires that coal fired power plants meet their more stringent requirements by December 31, 2025. With the addition of the 2024 EPA ELG Rule, coal fired power plants will now be expected to move to zero liquid discharge (ZLD) systems or permanently cease coal combustion by 2034. Due to this change, it is likely that coal fired power plants will be looking to design and install ZLD systems within the next decade. While …
Lunar Regolith Sintered Brick Apparatus, Andrew Fasano, Noah Parayil, Darius Felix Karra
Lunar Regolith Sintered Brick Apparatus, Andrew Fasano, Noah Parayil, Darius Felix Karra
Senior Design Project For Engineers
This project describes the preliminary design and analysis of the Semi-Autonomous Lunar Regolith Sintered Brick Apparatus that will assist in developing permanent infrastructure on the Moon. An issue with permanent lunar operations is the transportation of materials to the Moon. To address this, the designed device uses lunar regolith as the source material for producing bricks. This design considers the constraints set for operation with the Griffin lunar lander: maximum payload mass of 200 kg, power consumption below 5 kW, and limited payload dimensions. The design uses a combination of a laser sintering motion system, a regolith layering subsystem, a …
Cloud-Deployed Rna-Seq Analytics For Identifying Imaging And Therapeutic Targets In Chemotherapy-Induced Toxicities, Zhimu Wang
McKelvey School of Engineering Graduate Student Theses & Dissertations
Chemotherapy has significantly improved cancer survival rates; however, many anticancer agents induce severe acute and chronic side effects that substantially reduce patient quality of life and limit therapeutic efficacy. Despite their clinical importance, the molecular mechanisms underlying chemotherapy-induced toxicities across different organs remain incompletely understood, in part due to the lack of integrated, scalable, and accessible analytical platforms capable of synthesizing large transcriptomic datasets across tissues and experimental models.
This thesis describes the development of a cloud-deployed RNA-seq analytics platform designed to identify candidate imaging biomarkers and therapeutic targets associated with chemotherapy induced toxicities. The platform integrates large-scale transcriptomic datasets …
Establishing Sustainable Vegetation On A Challenging Legacy Ccr Site, Derek Oosterhouse, Blake Arthur
Establishing Sustainable Vegetation On A Challenging Legacy Ccr Site, Derek Oosterhouse, Blake Arthur
World of Coal Ash Proceedings
American Electric Power (AEP) is closing and restoring a legacy Coal Combustion Residuals (CCR) site in Ohio that once held a power plant that pioneered innovative steam generation technology. The plant was closed in 1975. Today, the legacy CCR site is being transformed back to natural, sustainable vegetation. To comply with and close the Stormwater Pollution Prevention Plan (SWPPP) permit, permanent stabilization is required on the site. AEP, one of the largest electric companies in the country, holds a core principle to respect the environment through creative sustainable solutions. AEP connected with Profile Products, the world’s largest manufacturer and supplier …
Improving Economic And Environmental Outcomes Of Legacy Coal Ash Ponds, Grace Wilken
Improving Economic And Environmental Outcomes Of Legacy Coal Ash Ponds, Grace Wilken
World of Coal Ash Proceedings
This project demonstrates a novel approach to utilize legacy coal ash waste ponds by processing the solids for use in cement/concrete and bioremediating the water fraction through algae cultivation. The algal biomass can then be used for animal feed, biofuels, or other valuable bio-products. There is an increasing demand for more environmentally friendly and cost-effective materials for concrete production, such as coal fly ash, yet a decreasing supply of ash as coal power plants are decommissioned in the transition to other energy sources. However, there are billions of tons of coal ash accumulated in legacy ash ponds across the US. …
Ensuring Quality Geosynthetics Installations Throughout The Project Lifecycle, Glen Toepfer
Ensuring Quality Geosynthetics Installations Throughout The Project Lifecycle, Glen Toepfer
World of Coal Ash Proceedings
Geosynthetics serve numerous functions in containment systems used within the Coal Ash Industry and ultimately protect the site owner from liability. A failure in the geosynthetics containment system exposes the owner to liability; therefore, it is imperative that these geosynthetic containment systems be installed correctly to mitigate the risk of failure. Avoiding failure is not just the responsibility of the geosynthetics installer – it is the responsibility of every party involved in the project lifecycle from conception through post-closure. In fact, the success of the field installation is largely determined before the first panel of geomembrane is ever installed. The …
Riki&Dolphin: Real Time Data Transmission From The Bottom Of A Cave To A Website, Luca Tringali, Giacomo Canciani Dr., Tecla Tripari, Alexander Debenjak, Caterina Bearzotti
Riki&Dolphin: Real Time Data Transmission From The Bottom Of A Cave To A Website, Luca Tringali, Giacomo Canciani Dr., Tecla Tripari, Alexander Debenjak, Caterina Bearzotti
International Journal of Speleology
Coming from over 10 years of experience in cave monitoring in northeast Italy, Gruppo Speleologico Talpe del Carso, has designed Riki and Dolphin: customizable, low cost, and easy to assemble tools for getting real time data transmission from the bottom of a cave, even underwater, to a webserver. Their use has been tested to monitor air temperature inside the Abisso Bonetti Cave (Classical Karst, Italy), proving for the first time that a cave in Gorizian Karst can systematically be colder than the outdoor temperature even in winter, recording an internal temperature even lower than 0°C. The Dolphin device can be …
Phytomining Potential Of Native Rocky Mountain Plants, Halle Cogley
Phytomining Potential Of Native Rocky Mountain Plants, Halle Cogley
Honors Theses
Standard mining practices of the past have left valuable, critical minerals remaining within mine waste and tailings piles. Phytoremediation, or the use of plants to uptake and store heavy metals, has grown in popularity for these sites. A new technology, phytomining, is being developed that not only offers the benefits of phytoremediation but also allows a new pathway to extract and generate revenue from these untouched critical minerals. Certain plants have been identified as hyperaccumulators with the ability to bioaccumulate a high level of certain minerals in their plant tissue. This study explored different species of native plants within the …
Phytoextraction Potential Of Willows (Salix Spp.) For Common Heavy Metal Contaminants., Johannes Chandler
Phytoextraction Potential Of Willows (Salix Spp.) For Common Heavy Metal Contaminants., Johannes Chandler
Honors Theses
Phytoextraction is a method for removal and recovery of heavy metals from contaminated substrates using plants. There is a growing need to test, identify, and further understand species effective for phytoextraction to feasibly remove and recover heavy metals. In this study, the phytoextraction capacity of Willow (Salix) species was tested for metal contaminated soils and waters from legacy mining in Butte, Montana. The willows were grown in a hydroponic system in two 8-week long growth trials, employing a 2x2 factorial design of contaminated soil, clay beads, contaminated mine water and uncontaminated water as the media. Heavy metal concentrations (Mn, Zn, …
Voltage-Sensor–Targeting Modulators Of Iks: Identifying Critical Functional Groups Of C28 Via Electrophysiology And Sar Modeling, Jiacheng Huang
Voltage-Sensor–Targeting Modulators Of Iks: Identifying Critical Functional Groups Of C28 Via Electrophysiology And Sar Modeling, Jiacheng Huang
McKelvey School of Engineering Graduate Student Theses & Dissertations
IKs (KCNQ1/KCNE1) channels are essential for cardiac repolarization, and their dysfunction contributes to arrhythmogenic disorders such as Long QT Syndrome type 1 (LQT1). Pharmacological activation of IKs has therefore emerged as a promising therapeutic strategy. C28, a recently identified voltage-sensor–targeting activator, has been shown to markedly shift KCNQ1/KCNE1 voltage dependence and enhance current amplitude, validating the voltage-sensing domain (VSD) as a druggable site. However, the structural determinants that underlie C28’s activity remain incompletely understood. In this study, we aimed to identify critical functional groups of C28 by screening a structurally diverse set of C28-like analogs and evaluating their …
Transportation Logistics Panel, John Ward, Andrew Vollmer, Tracy Zea, Marci Jenks
Transportation Logistics Panel, John Ward, Andrew Vollmer, Tracy Zea, Marci Jenks
World of Coal Ash Proceedings
As the industry shifts from freshly generated ash to harvested materials and advanced utilization, logistics is becoming one of the primary drivers of project success or failure. This moderated panel will explore how sourcing, transportation, and storage realities are changing — and what project teams most often underestimate when working with harvested coal ash. Panelists will discuss what breaks, what becomes more complex, and how logistics considerations are reshaping planning and development.
Leveraging Information Theory And Ecological Network Analysis To Monitor Communication Networks In A Student Aerospace Team, Christine Sessions
Leveraging Information Theory And Ecological Network Analysis To Monitor Communication Networks In A Student Aerospace Team, Christine Sessions
Doctoral Dissertations and Master's Theses
Effective communication is a critical component of successful collaboration in group projects and team settings. However, systematically tracking and analyzing team communications can be challenging, especially in complex, multi-member teams such as those found in the aerospace industry. This paper explores an information-theoretic approach that leverages encoding techniques and graph theory to analyze communication networks within a university’s multi-year, student-led cubesat design project (Project COMET). By utilizing Shannon Entropy as a measure of information flow, encoding communication patterns, and analyzing Ecological Network Analysis parameters, this research aims to understand how an Embry-Riddle Aeronautical University student project team evolves over the …
Ais26s: Ai In Biomedicine, Shiqian Shen
Ais26s: Ai In Biomedicine, Shiqian Shen
Paul English Applied Artificial Intelligence (AI) Institute Publications
This presentation explores the role of artificial intelligence in advancing biomedical research and clinical practice from the perspective of a physician-scientist. Dr. Shiqian Shen discusses current challenges in neuroscience and medicine, including limitations in human observation, data analysis, and decision-making across complex biological systems. The talk highlights how AI-driven approaches such as computer vision, neural signal processing, and large-scale data modeling can improve the understanding of disease mechanisms, enhance experimental workflows, and enable more precise, patient-centered care. Specific applications include automated classification of neural activity, behavioral analysis in animal models, and multimodal data integration. A key concept introduced is “shadow …
Introduction To Computer-Aided Design Using Solidworks® : A Structured Approach To Parametric Modeling And Design Intent, Swapnil Moon
Introduction To Computer-Aided Design Using Solidworks® : A Structured Approach To Parametric Modeling And Design Intent, Swapnil Moon
Open and Affordable Textbooks
This textbook introduces computer-aided design (CAD) using SOLIDWORKS® through a structured, design-centered approach that emphasizes parametric modeling and engineering reasoning. Rather than focusing solely on software commands, the material develops foundational skills in design intent, constraint-based modeling, and feature relationships to create robust, adaptable models.
The content is organized progressively, beginning with basic sketching and feature creation and advancing to complex part modeling, assemblies, motion studies, and engineering drawings. Each chapter builds upon prior concepts, reinforcing systematic modeling practices and promoting the development of system-level thinking required in real-world engineering design workflows.
Designed for undergraduate students with little or no …
Optimizing College Food Pantry Locker Systems Through Simulation Techniques, Jacob W. Holmes
Optimizing College Food Pantry Locker Systems Through Simulation Techniques, Jacob W. Holmes
Industrial Engineering Undergraduate Honors Theses
Food insecurity affects 10.5% of households in the United States. Among those affected, college students are a group with increasing food insecurity. Through novel food pantry order methods, such as locker order systems, some effects of college food insecurity can be alleviated. The Jane B. Gearhart Full Circle Food Pantry (FCFP) at the University of Arkansas implemented a locker system, beginning in the Fall of 2020. There is a lack of investigation into locker management policies for pantries, such as how much time clients should be allowed to pick up orders after they are placed in lockers, how many lockers …
Adsorption Of Pfas On Bridged Functionalized Organosilica Materials, Elisha Lawerh Kabutey
Adsorption Of Pfas On Bridged Functionalized Organosilica Materials, Elisha Lawerh Kabutey
Electronic Theses and Dissertations
PFAS are hazardous contaminants that have a devastating impact on human health and the environment. Their hazardous nature has led to the development of various adsorption methods for removing these contaminants from water sources. In this study, functionalized organosilica materials were synthesized from bis[3-(trimethoxysilyl)propyl] amine using the sol-gel method. The surface amino groups of the organosilica were converted into amine hydrochloride groups. Their adsorption properties were evaluated using salts of perfluorooctanoic acid, perfluorooctanesulfonic acid, and perfluorobutanesulfonic acid. Results showed excellent adsorption capacity of the materials. Adsorption of PFAS leads to particle agglomeration and flotation of the spent material. A column …
The Influence Of Social Media On The Product Life Cycle In Fast Fashion: A Shein Case Study On Environmental And Social Impacts, Clara R. Devine
The Influence Of Social Media On The Product Life Cycle In Fast Fashion: A Shein Case Study On Environmental And Social Impacts, Clara R. Devine
Industrial Engineering Undergraduate Honors Theses
Fast fashion has transformed global consumer culture through its rapid product cycles, affordability, and accessibility. However, this model has also contributed significantly to environmental degradation, excessive textile waste, and unethical labor practices. Social media platforms have accelerated these patterns by amplifying short-lived trends and influencing consumer purchasing behavior. This study aims to analyze the relationship between social media activity and the fast-fashion life cycle, with a focus on how online engagement drives consumption, production speed, and environmental impact. The research utilized a quantitative and analytical approach, combining correlation analysis and time-series data to evaluate the connection between SHEIN’s growing user …
Developing Aero-Floating Treatment Wetland (Aeroftw) Scaffolds: A Non-Plastic Alternative To Conventional Plastic-Based Ftws, Ada C. Montoya Gomez
Developing Aero-Floating Treatment Wetland (Aeroftw) Scaffolds: A Non-Plastic Alternative To Conventional Plastic-Based Ftws, Ada C. Montoya Gomez
All Theses
This research was conducted to explore the possibility of constructing floating treatment wetlands (FTWs) without using plastic materials. FTWs are floating platforms that hold plants on the water’s surface, letting roots dangle within the water column, to help remove contaminants from contaminated water, especially in stormwater ponds. Many conventional FTWs are made with plastic components, such as mats and plastic cup containers, which can release microplastics into the environment over time. The goal of this project was to design and test a new type of FTW that does not depend on plastics to support FTW flotation. The study took place …
Fluorescence-Based Quantification Of Hepatic Ldl Uptake And Donor Hepatocyte Engraftment Using Atto 700–Labeled Ldl, Victor Agustin Cortes Flores
Fluorescence-Based Quantification Of Hepatic Ldl Uptake And Donor Hepatocyte Engraftment Using Atto 700–Labeled Ldl, Victor Agustin Cortes Flores
All Theses
Familial hypercholesterolemia (FH) is an inherited disorder characterized by elevated low-density lipoprotein cholesterol (LDL-C) that increases the risk of premature atherosclerotic cardiovascular disease. In severe FH, including low-density lipoprotein receptor (LDLR), hepatic LDL clearance is profoundly impaired and many lipid lowering treatment strategies have limited effectiveness. Current advances in ex vivo CRISPR–Cas9 hepatocyte gene editing in vivo and ex vivo approaches for treatment of FH are under development.
However, a central barrier to translation is the ability to quantitatively measure the percentage of healthy gen edited hepatocytes in the liver while simultaneously assessing functional hepatic LDL handling. This thesis establishes …
Freshwater Mussel Reintroduction And Recolonization Habitat Modeling Using Hydraulic, Sediment And Geomorphic Parameters, Megan Elizabeth Dinicola
Freshwater Mussel Reintroduction And Recolonization Habitat Modeling Using Hydraulic, Sediment And Geomorphic Parameters, Megan Elizabeth Dinicola
All Graduate Theses and Dissertations, Fall 2023 to Present
Freshwater mussels are an important group of aquatic animals that live within the riverbed, but their populations have been drastically reduced by habitat alteration and other anthropogenic activities. In an effort to bolster populations, river managers and biologists are using mussel reintroductions as part of their restoration efforts but there are gaps in our understanding of where to reintroduce mussels within a river to see them create self-sustaining populations. This research helps shrink this gap by better understanding the physical habitat needs and population expansion potential of subadult freshwater mussels, or the size of mussel that hatcheries grow for reintroduction, …
Establishing Caenorhabditis Elegans As A Platform For Bioaccumulation And Selectivity Screening Of Anthelmintic Compounds, Jiarui Li
McKelvey School of Engineering Graduate Student Theses & Dissertations
To address the cuticular barrier in anthelmintic discovery, this study establishes a bifurcated framework in Caenorhabditis elegans. First, HPLC-based quantification of 14 PIM inhibitors revealed that cuticular penetrance is primarily dictated by phylogenetic lineage (Clade V) rather than ecological niche. Specifically, C. elegans demonstrated a significant pharmacokinetic correlation with the hookworm Ancylostoma ceylanicum (Clade V) but not the whipworm Trichuris muris (Clade I), validating it as a superior surrogate model for hookworm bioaccumulation. Within this small molecule inhibitor library, SGI-12was identified as a lead candidate with superior potency against C. elegans and bioaccumulation. Second, target validation using a C. …