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Digital Human Models Of People With Disabilities, Ron Hamameh Jan 2010

Digital Human Models Of People With Disabilities, Ron Hamameh

Wayne State University Theses

The current state-of-the-art in Digital Human Modeling (DHM) allows for full simulation and analysis of any task a person is required to perform at home, at work, in the military, in space, in sports, etc. The problem is that the software is missing a very important population: people with physical disabilities. What modifications and enhancements must be made to existing, commercially available DHM software to include this population?


Harmonic/Percussive Separation Using Median Filtering, Derry Fitzgerald Jan 2010

Harmonic/Percussive Separation Using Median Filtering, Derry Fitzgerald

Conference papers

In this paper, we present a fast, simple and effective method to separate the harmonic and percussive parts of a monaural audio signal.The technique involves the use of median filtering on a spectrogram of the audio signal, with median filtering performed across successive frames to suppress percussive events and enhance harmonic components, while median filtering is also performed across frequency bins to enhance percussive events and supress harmonic components. The two resulting median filtered spectrograms are then used to generate masks which are then applied to the original spectrogram to separate the harmonic and percussive parts of the signal. We …


Kentucky Traffic Collision Facts 2010 Report, Kentucky Transportation Center, Kentucky State Police Jan 2010

Kentucky Traffic Collision Facts 2010 Report, Kentucky Transportation Center, Kentucky State Police

Kentucky Transportation Center Research Report

KENTUCKY’S TRAFFIC COLLISION FACTS report for 2010 is based on collision reports submitted to the Kentucky State Police Records Branch. As required by Kentucky Revised Statutes 189.635, “every law enforcement agency whose officers investigate a vehicle accident of which a report must be made...shall file a report of the accident...within ten days after investigation of the accident upon forms supplied by the bureau.” The stated purpose of this requirement is to utilize data on traffic collisions for such purposes as will improve the traffic safety program in the Commonwealth. Data contained in this report are based solely on the observations …


A Novel Image Processing Platform Development For Preprocessing Images With Two-Phase Microstructures Containing Isolated Particles, Yuxiu Zhang Jan 2010

A Novel Image Processing Platform Development For Preprocessing Images With Two-Phase Microstructures Containing Isolated Particles, Yuxiu Zhang

Wayne State University Theses

A novel image processing platform is developed in this thesis for pre-processing the images of two-phase microstructures containing isolated particles based on Matlab®. The two phases in this work represent martensite particles and ferrite matrix in Dual Phase steels that are developed for lightweight automotive body structures. An automated image processing tool is useful for obtaining statistical microstructure characteristics, important for better understanding material's deformation and fracture behavior. However, a generalized commercial software can not automatically realize the microstructural features of special interest, and a user-specified pre-processing tool is needed.

This platform utilizes the Matlab® GUI technique, Matlab image processing …


Application Of Magnetic Resonance Imaging To Understanding The Pathogenesis Of The X-Linked Leukodystrophy Pelizaeus-Merzbacher Disease, Jeremy Jerome Laukka Jan 2010

Application Of Magnetic Resonance Imaging To Understanding The Pathogenesis Of The X-Linked Leukodystrophy Pelizaeus-Merzbacher Disease, Jeremy Jerome Laukka

Wayne State University Dissertations

Myelin is a multilamellar membrane structure surrounding axons in both the CNS and PNS that facilitates nerve conduction. In the CNS, myelin is synthesized by oligodendrocytes, while in the PNS, myelin is synthesized by Schwann cells. In the CNS, Proteolipid protein 1 (PLP1), an integral membrane protein, is the major protein component of myelin, constituting ~50% of myelin protein. Mutations of the PLP1 gene in man cause a spectrum of neurological disease, ranging from the severe Pelizaeus-Merzbacher disease (PMD), that typically begins during infancy with nystagmus, seizures and hypotonia and evolves into spastic quadriparesis, cognitive impairment and ataxia, to ¡¥pure¡¦ …


Effect Of Alternative Fuels On Aftertreatment Device, Bunpreet Singh Jan 2010

Effect Of Alternative Fuels On Aftertreatment Device, Bunpreet Singh

Wayne State University Theses

EFFECT OF ALTERNATIVE FUELS ON THE AFTERTREATMENT DEVICE.

by

BUNPREET SINGH

Dec 2010

Advisor: Dr. Dinu Taraza

Major: Mechanical Engineering

Degree: Master of Science

There is no doubt that globally, alternative fuels have attained the center of attention in order to reduce the dependency on fossil fuels. A lot of research has been conducted on the alternative fuels in the automotive industry pertaining to the sustainability, engine performance and the emission characteristics.

The focus of this study is to investigate the effect of alternative fuels (JP8, Soy-based B20, and S8) on the aftertreatment device. Different fuel properties (both physical and …


Asynchronous Particle Swarm Optimization-Based Search With A Multi-Robot System: Simulation And Implementation On A Real Robotic System, Sali̇h Burak Akat, Veysel Gazi̇, Lino Marques Jan 2010

Asynchronous Particle Swarm Optimization-Based Search With A Multi-Robot System: Simulation And Implementation On A Real Robotic System, Sali̇h Burak Akat, Veysel Gazi̇, Lino Marques

Turkish Journal of Electrical Engineering and Computer Sciences

In this article we consider a version of the Particle Swarm Optimization (PSO) algorithm which is appropriate for search tasks of multi-agent systems consisting of small robots with limited sensing capability. The proposed method adopts asynchronous mechanism for information exchange and position (way point) updates of the agents. Moreover, at each (information exchange) step the agents communicate with only a possibly different subset of the other agents leading to a dynamic neighborhood topology. We implement the algorithm using the Player/Stage realistic robot simulator as well as on real KheperaIII robots using experimentally collected realistic data of ethanol gas concentration. Simulation …


Program And Proceedings: Nebraska Academy Of Sciences 1880–2010, 130th Anniversary Year, One Hundred-Twentieth Annual Meeting Jan 2010

Program And Proceedings: Nebraska Academy Of Sciences 1880–2010, 130th Anniversary Year, One Hundred-Twentieth Annual Meeting

Nebraska Academy of Sciences: Programs and Proceedings

Program

Aeronautics and Space Science

Chemistry and Physics

Collegiate Academy: Biology

Collegiate Academy: Chemistry and Physics

Biological and Medical Sciences

Chemistry and Physics

History and Philosophy of Science

Nebraska Wesleyan University Health and Sciences Graduate School Fair

Junior Academy, Senior High Competition/p>

Aeronautics and Space Science, Poster Session

Teaching of Science and Math

Maiben Memorial Lecture: Mark Greip, Department of Chemistry, University of Nebraska–Lincoln

Aeronautics

Anthropology

Junior Academy, Senior High Competition

Earth Science

Junior Academy, Junior High Competition


Nanivid : A New Research Tool For Tissue Microenvironment Studies, Waseem Khan Raja Jan 2010

Nanivid : A New Research Tool For Tissue Microenvironment Studies, Waseem Khan Raja

Legacy Theses & Dissertations (2009 - 2024)

Metastatic tumors are heterogeneous in nature and composed of subpopulations of cells having various metastatic potentials. The time progression of a tumor creates a unique microenvironment to improve the invasion capabilities and survivability of cancer cells in different microenvironments. In the early stages of intravasation, cancer cells establish communication with other cell types through a paracrine loop and covers long distances by sensing growth factor gradients through extracellular matrices. Cellular migration both in vitro and in vivo is a complex process and to understand their motility in depth, sophisticated techniques are required to document and record events in real time. …


Effect Of Transformer On Stochastic Estimation Of Voltage Sag Due To Faults In The Power System: A Pscad/Emtdc Simulation, Nita R. Patne, K. L. Thakre Jan 2010

Effect Of Transformer On Stochastic Estimation Of Voltage Sag Due To Faults In The Power System: A Pscad/Emtdc Simulation, Nita R. Patne, K. L. Thakre

Turkish Journal of Electrical Engineering and Computer Sciences

Voltage sags in the electric power system are mostly due to faults in the power system. Voltage sag is characterized by its magnitude (the retained voltage), phase-angle jump, unbalance in the sag in the three phases, and duration. Type of transformers in the electrical system is the important parameter influencing the characteristic of sag at the node where sensitive loads are connected. For sensitive loads it is necessary to estimate how many times in a year the voltage at their terminal will experience sag to avoid tripping of operation. In this paper the effect of transformer on stochastic estimation of …


Active Illumination And Appearance Model For Face Alignment, Muhi̇tti̇n Gökmen, Fati̇h Kahraman, Sune Darkner, Rasmus Larsen Jan 2010

Active Illumination And Appearance Model For Face Alignment, Muhi̇tti̇n Gökmen, Fati̇h Kahraman, Sune Darkner, Rasmus Larsen

Turkish Journal of Electrical Engineering and Computer Sciences

Illumination conditions have an explicit effect on the performance of face recognition systems. In particular, varying the illumination upon the face imposes such complex effects that the identification often fails to provide a stable performance level. In this paper, we propose an approach integrating face identity and illumination models in order to reach acceptable and stable face recognition rates. For this purpose, Active Appearance Model (AAM) and illumination model of faces are combined in order to obtain an illumination invariant face localization. The proposed method is an integrated Active Illumination and Appearance Model (AIA) which combines identity, illumination and shape …


Sdre Optimal Control Of Drug Administration In Cancer Treatment, Mehmet İti̇k, Meti̇n Uymaz Salamci̇, Stephen Paul Banks Jan 2010

Sdre Optimal Control Of Drug Administration In Cancer Treatment, Mehmet İti̇k, Meti̇n Uymaz Salamci̇, Stephen Paul Banks

Turkish Journal of Electrical Engineering and Computer Sciences

In this study, we apply State Dependent Riccati Equation (SDRE) based optimal control technique to a nonlinear tumor growth model. The model consists of three biological cells which are normal tissue, tumor and immune cells. The effect of chemotherapy treatment is also included in the model. Chemotherapy administration is considered as a control input to the nonlinear cancer dynamics and the amount of administered drug is determined by using SDRE optimal control. The optimal control is applied to the model in order not only to drive the tumor cells to the healthy equilibrium state but also to minimize the amount …


Investigating Rfid For Roadside Identification Involving Freight Commercial Vehicle Operators (Cvo), Erick C. Jones Ph.D., Judy Perkins Ph.D. Jan 2010

Investigating Rfid For Roadside Identification Involving Freight Commercial Vehicle Operators (Cvo), Erick C. Jones Ph.D., Judy Perkins Ph.D.

Mid-America Transportation Center: Final Reports and Technical Briefs

Radio Frequency Identification (RFID) is an emerging technology to track commercial vehicles. This transcript describes research that investigates the ability for RFID technologies to work in license plates. Mile markers are common fixtures on the roadside and may provide infrastructure to support identifying RFID to enabled Commercial Vehicle Operators (CVO). This research considers variables that affect the performance of a RFID License Plate System that uses a scanner located at the mile marker. Mile marker characteristics, such as horizontal distance and vertical height, were evaluated along with RFID tag characteristics, such tag type and license plate location.


2010 Nebraska Water Monitoring Programs Report, Marty Link Jan 2010

2010 Nebraska Water Monitoring Programs Report, Marty Link

Nebraska Department of Environmental Quality: Reports

The Nebraska Department of Environmental Quality (NDEQ) is charged with monitoring, assessing, and to the extent possible, managing the state’s water resources. The purpose of this work is to protect and maintain good quality water and encourage or execute activities to improve poor water quality. Monitoring is done on the over 18,000 miles of flowing rivers and streams, our greater than 280,000 acres of surface water in lakes and reservoirs, and the vast storage of groundwater in Nebraska’s aquifers.


Microbial Treatment Of Swine Fecal Waste To Generate Long-Chain Linear Alkanes After Fast Pyrolysis, Lisa A. Fitzgerald, C. Ziemer, S. E. Lizewski, Bradley R. Ringeisen, K. Henry, Justin C. Biffinger Jan 2010

Microbial Treatment Of Swine Fecal Waste To Generate Long-Chain Linear Alkanes After Fast Pyrolysis, Lisa A. Fitzgerald, C. Ziemer, S. E. Lizewski, Bradley R. Ringeisen, K. Henry, Justin C. Biffinger

United States Navy: Publications

Research into the generation of energy from human and animal waste has been primarily focused on gas production (especially methane and hydrogen). While there is some work concentrated on ethanol and biodiesel creation from wastes (fuels used for ground transportation primarily), increasing research interest has been recently directed toward long chain hydrocarbon production for aviation fuels. Kerosene components from swine fecal waste have been generated from four natural sources: undigested dietary lipids, host lipids excreted in feces, bacterial cell walls and products of bacterial fermentation.


Activity Of Topical Antimicrobial Agents Against Multidrug-Resistant Bacteria Recovered From Burn Patients, Jessie S. Glasser, Charles H. Guymon, Katrin Mende, Steven E. Wolf, Duane R. Hospenthal, Clinton K. Murray Jan 2010

Activity Of Topical Antimicrobial Agents Against Multidrug-Resistant Bacteria Recovered From Burn Patients, Jessie S. Glasser, Charles H. Guymon, Katrin Mende, Steven E. Wolf, Duane R. Hospenthal, Clinton K. Murray

United States Army: Publications

Background:

Topical antimicrobials are employed for prophylaxis and treatment of burn
wound infections despite no established susceptibility breakpoints, which are becoming vital in an era of multidrug-resistant (MDR) bacteria. We compared two methods of determining topical antimicrobial susceptibilities.

Methods:

Isolates of Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus (MRSA), extended spectrum beta-lactamase (ESBL) producing Klebsiella pneumoniae, and Acinetobacter baumanii-calcoaceticus (ABC) from burn patients were tested using broth microdilution and agar well diffusion to determine minimum inhibitory concentrations (MICs) and zones of inhibition (ZI). Isolates had systemic antibiotic resistance and clonality determined. MDR included resistance to antibiotics in three or more …


Toxicity And Bioaccumulation Of Tnt In Marine Fish In Sediment Exposures, Guilherme R. Lotufo, William Blackburn, Sydney J. Marlborough, John W. Fleeger Jan 2010

Toxicity And Bioaccumulation Of Tnt In Marine Fish In Sediment Exposures, Guilherme R. Lotufo, William Blackburn, Sydney J. Marlborough, John W. Fleeger

United States Army: Publications

The bioaccumulation potential and toxicity of 2, 4, 6-trinitrotoluene (TNT) spiked to sediment was evaluated in juvenile sheeps head minnows (JSHM, Cyprinodon variegatus) and adult freckled blennies (FB, Hypsoblennius ionthas). The JSHM were exposed for 4 days in the presence or absence of a mesh separating fish from sediment. FB were exposed to sediment for 7 days. During the 24-day storage period(4 °C), extensive transformation of spiked TNT occurred and concentrations are expressed as the sum of TNT, aminodinitrotoluenes and diaminonitrotoluenes (Sum TNT), on a dry weight basis. Sum TNT in the overlying water, not exchanged during exposure, …


Igf-I Releasing Plga Scaffolds For Growth Plate Regeneration, Sharath Kumar Chinnakavanam Sundararaj Jan 2010

Igf-I Releasing Plga Scaffolds For Growth Plate Regeneration, Sharath Kumar Chinnakavanam Sundararaj

University of Kentucky Master's Theses

Growth plate is a highly organized cartilaginous tissue found at the end of long bones and is responsible for longitudinal growth of the bones. Growth plate fracture leads to retarded growth and unequal limb length, which might have a lifelong effect on a person’s physical stature. This research is a tissue engineering approach for the treatment of growth plate injury. Insulin-like growth factor I (IGF-I), which can stimulate cartilage formation, was encapsulated within PLGA microspheres that were then used to form porous scaffolds. The release profile of the IGF-I from the PLGA scaffold showed a biphasic release pattern. In vitro …


Microalgal Bioremediation Of Nutrients In Wastewater And Carbon Dioxide In Flue Gas, Anand Murali Narasimhan Jan 2010

Microalgal Bioremediation Of Nutrients In Wastewater And Carbon Dioxide In Flue Gas, Anand Murali Narasimhan

Masters Theses

"Microalgae are potential biofuel feedstocks that can provide solutions to the twin challenges of energy security and environmental pollution. They have great potential for the removal of excess nitrogen and phosphorus from wastewater including the farm runoff. They can capture carbon dioxide in the flue gas from coal fired power plants thereby reducing greenhouse gas and also producing algal biomass, which can be converted into biofuel. In this study, the nutrient consumption of Scenedesmus algae was investigated in a batch culture and the biomass yield was determined. Algae were able to utilize carbon in the form of soluble carbonates which …


Application Of Life Cycle Assessment To Estimate Environmental Impacts Of Surface Coal Mining, Ofentse Ditsele Jan 2010

Application Of Life Cycle Assessment To Estimate Environmental Impacts Of Surface Coal Mining, Ofentse Ditsele

Masters Theses

"Coal plays an important role in meeting the energy needs of the World. Given its abundance and low cost, its use is bound to increase with the growing energy demand. Despite its importance, there are concerns over coal's environmental burdens. In order to extract and use coal in a sustainable manner, sustainability assessment has to be comprehensive. Life Cycle Assessment (LCA) provides systematic and quantifiable measures for assessing environmental burdens of products and processes. Extensive LCA work has been done on coal use, particularly in electricity generation, but, the coal mining stage has been neglected, for the most part. This …


Implementation Of Risk Management In The Medical Device Industry, Rachelo Dumbrique Jan 2010

Implementation Of Risk Management In The Medical Device Industry, Rachelo Dumbrique

Master's Theses

This study looks at the implementation and effectiveness of risk management (RM) activities in the medical device industry. An online survey was distributed to medical device professionals who were asked to identify RM-related activities performed during the device life cycle. RM activities and techniques included Establishing Risk Acceptance Criteria, Hazard Identification, Human Factors/Usability, Fault Tree Analysis (FTA), Design Failure Mode and Effects Analysis (DFMEA), Process Failure Mode and Effects Analysis (PFMEA), Hazard and Operability Study (HAZOP), Hazard Analysis and Critical Control Point (HACCP), Risk Benefit Analysis, and Risk Assessment of Customer Complaint. Devices were identified by type (therapeutic, surgical/clinical tools, …


Characterizing The Controlled Release Of Glial Cell-Line Derived (Gdnf) Neurotrophic Factor From Encapsulated Schwann Cells, Kristy Broadrick Jan 2010

Characterizing The Controlled Release Of Glial Cell-Line Derived (Gdnf) Neurotrophic Factor From Encapsulated Schwann Cells, Kristy Broadrick

Wayne State University Theses

ABSTRACT

CHARACTERIZING THE CONTROLLED RELEASE OF GDNF IN SCHWANN CELLS

by

KRISTY BROADRICK

May 2010

Advisor: Dr. Pamela VandeVord

Major: Biomedical Engineering

Degree: Masters of Science

Controlled expression of glial cell line derived neurotrophic factor (GDNF) can be integrated in the development of a system for repair of injured peripheral nerves. This delivery strategy was demonstrated via inducible GDNF from microencapsulated cells in barium alginate. The Schwann cell line RT4-D6P2T was initially modified utilizing an ecdysone-based stable transfection system to produce RT4-GDNF cells. During construct preparation, it was found that C6 cells (where GDNF cDNA was isolated) make three GDNF …


Scaffold Based In-Vitro Osteodistraction For Bone Tissue Engineering, Cesar Adrian Terrazas Jan 2010

Scaffold Based In-Vitro Osteodistraction For Bone Tissue Engineering, Cesar Adrian Terrazas

Open Access Theses & Dissertations

Engineering of hard tissues such as bone is a challenge because of the limited ability of the body to heal large defects. Current treatment options, such as employing bone sections from the patient or a deceased donor have been utilized for some time now with various degrees of success. However, these methods still exhibit many limitations such as limited supply and the possibility of transmission of disease.

To address the many limitations of bone grafts, synthetic engineered substitutes have been developed and widely researched for nearly three decades. Generally termed scaffolds, these are matrices that serve the purpose of temporary …


Investigating Fabrication Methods For Micro Single-Chamber Solid Oxide Fuel Cells, Man Yang Jan 2010

Investigating Fabrication Methods For Micro Single-Chamber Solid Oxide Fuel Cells, Man Yang

Dissertations

A Solid Oxide Fuel Cell (SOFC) is a green energy technology that offers a cleaner and efficient alternative to fossil fuels. The efficiency and utility of SOFCs can be enhanced by fabricating miniaturized component structures within the fuel cell footprint. This research focuses on the microfabrication of parallel-connected inter-digitized design of micro single chamber SOFC (µ-SC-SOFCs). In this dissertation, candidate micro/nano fabrication techniques to precisely fabricate micro patterns on planar substrates have been studied. These include EBL, soft lithography, photolithography, and direct-writing. After analyzing preliminary results, two combinational approaches were further investigated. The first method involves the combination of the …


Biosignal Processing Challenges In Emotion Recognitionfor Adaptive Learning, Aniket Vartak Jan 2010

Biosignal Processing Challenges In Emotion Recognitionfor Adaptive Learning, Aniket Vartak

Electronic Theses and Dissertations

User-centered computer based learning is an emerging field of interdisciplinary research. Research in diverse areas such as psychology, computer science, neuroscience and signal processing is making contributions the promise to take this field to the next level. Learning systems built using contributions from these fields could be used in actual training and education instead of just laboratory proof-of-concept. One of the important advances in this research is the detection and assessment of the cognitive and emotional state of the learner using such systems. This capability moves development beyond the use of traditional user performance metrics to include system intelligence measures …


Development Of Optical Coherence Tomography For Tissue Diagnostics, Panomsak Meemon Jan 2010

Development Of Optical Coherence Tomography For Tissue Diagnostics, Panomsak Meemon

Electronic Theses and Dissertations

Microvasculature can be found in almost every part of the human body, including the internal organs. Importantly, abnormal changes in microvasculature are usually related to pathological development of the tissue cells. Monitoring of changes in blood flow properties in microvasculature, therefore, provides useful diagnostic information about pathological conditions in biological tissues as exemplified in glaucoma, diabetes, age related macular degeneration, port wine stains, burn-depth, and potentially skin cancer. However, the capillary network is typically only one cell in wall thickness with 5 to 10 microns in diameter and located in the dermis region of skin. Therefore, a non-invasive flow imaging …


Simulation For Commercial Driver License Third Party Tester Testing, Henry Truong Jan 2010

Simulation For Commercial Driver License Third Party Tester Testing, Henry Truong

Electronic Theses and Dissertations

The advance of technology is thought to help ease the myriad tasks that are usually involved in operating equipment. Training and testing in modern times have been replacing with simulation technologies that mimic the actual live operations and testing. Many successful stories of flight simulation come from military fighter aircraft and commercial pilot programs. The possibilities of safety in saving lives, economic incentive in reducing the operational cost and reducing the carbon footprint via simulation makes simulation worth looking into. These considerations quickly boosted the transfer from live training operations to virtual and simulation, as were easily adopted in the …


Laser Plasma Radiation Studies For Droplet Sources In The Extreme Ultraviolet, Reuvani Kamtaprasad Jan 2010

Laser Plasma Radiation Studies For Droplet Sources In The Extreme Ultraviolet, Reuvani Kamtaprasad

Electronic Theses and Dissertations

The advancement of laboratory based Extreme Ultraviolet (EUV) radiation has escalated with the desire to use EUV as a source for semiconductor device printing. Laser plasmas based on a mass-limited target concept, developed within the Laser Plasma Laboratory demonstrate a much needed versatility for satisfying rigorous source requirements. This concept produces minimal debris concerns and allows for the attainment of high repetition rates as well as the accommodation of various laser and target configurations. This work demonstrates the generation of EUV radiation by creating laser plasmas from mass-limited targets with indium, tin, and antimony doped droplets. Spectral emission from the …


An Analytical Model For Rotator Cuff Repairs, A. Aurora, Jorge E. Gatica, Antonie J. Van Den Bogert, J. A. Mccarron, Kathleen A. Derwin Jan 2010

An Analytical Model For Rotator Cuff Repairs, A. Aurora, Jorge E. Gatica, Antonie J. Van Den Bogert, J. A. Mccarron, Kathleen A. Derwin

Mechanical Engineering Faculty Publications

Background

Currently, natural and synthetic scaffolds are being explored as augmentation devices for rotator cuff repair. When used in this manner, these devices are believed to offer some degree of load sharing; however, no studies have quantified this effect. Furthermore, the manner in which loads on an augmented rotator cuff repair are distributed among the various components of the repair is not known, nor is the relative biomechanical importance of each component. The objectives of this study are to (1) develop quasi-static analytical models of simplified rotator cuff repairs, (2) validate the models, and (3) predict the degree of load …


Branched And Spiral Organic Nanotubes Based On The Self-Assembly Of Bile Acids, Xuejun Zhang Jan 2010

Branched And Spiral Organic Nanotubes Based On The Self-Assembly Of Bile Acids, Xuejun Zhang

Electronic Theses and Dissertations

The self-assembly of chiral amphiphilic molecules in aqueous solutions is of particular interest because the chirality of individual molecules is often expressed in their supermolecular structures. Self-assembled tubes made of chiral amphiphilic molecules represent useful supramolecular architectures which hold promise as controlled release vehicles for drug delivery, encapsulates for functional molecules, and nanoreactors for chemical reactions. Lithocholic acid (LCA) is a secondary bile acid with the concentration being identical to that of cholesterol in the hepatic bile and gallbladder. It has a rigid, nearly planar hydrophobic steroid nucleus, with four hydrogen atoms and one hydroxyl group directed toward the concave …