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Osteoclast-Mediated Cell Therapy As An Attempt To Treat Elastin-Specific Vascular Calcification, Chartrisa Simpson

All Dissertations

Vascular calcification occurs during physiological aging and is clinically recognized as a major risk factor for myocardial infarction, systolic hypertension, heart failure and coronary insufficiency caused by loss of aortic recoil. Medial arterial calcification is an active remodeling process that involves the deposition of bone-specific matrix in close association with elastic fibers. Elastin, a major structural protein in the extracellular matrix of arterial walls, provides elastic recoil to the arteries. Increasing evidence suggests that vascular calcification share features with skeletal bone formation such as bone matrix deposition and bone resorption. Bone morphogenetic proteins and bone cells have been found in …

Finite Element Modeling Of Icd Lead Silicone Soft-Tips, Jose J. Lepe

Master's Theses

Although highly underutilized by the medical device industry, Finite Element Analysis (FEA) in the development of new technologies is gaining popularity as regulatory bodies such as the Food and Drug Administration (FDA) begin to require additional proof of safety through scientific methods. Non-linear FEA allows engineers to realistically simulate the mechanical behavior of implants as seen in the in-vitro, or in some cases, the in-vivo configurations. The work presented in this report investigates how computational methods can be used to simulate the interaction of a St. Jude Medical silicone soft-tip as it passes through a Peel-Away Sheath (i.e. introducer). In …

Neural Networks And The Natural Gradient, Michael R. Bastian

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Neural network training algorithms have always suffered from the problem of local minima. The advent of natural gradient algorithms promised to overcome this shortcoming by finding better local minima. However, they require additional training parameters and computational overhead. By using a new formulation for the natural gradient, an algorithm is described that uses less memory and processing time than previous algorithms with comparable performance.

Comparison Of Agricultural Area Source Ammonia Gas Concentration And Flux Measurements, Emyrei Reese

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This study was conducted in order to compare and evaluate a variety of ammonia (NH₃) measurement techniques for determination of ambient gas phase concentration and evaluation of system fluxes. This was accomplished by measuring NH3 emitted from area sources within two dairies, one located in south-central Idaho and another in central California. The measurement techniques utilized included: an array of passive diffusion samplers, a single annular denuder system, a single or paired Fourier transform infrared spectrometer(s) (FTIR), a paired (upwind and downwind) set of differential optical absorption spectrometers (DOAS), and a portable wind tunnel in conjunction with a …

Fundamentals Of Operation Of The Induced Bed Reactor (Ibr) Anaerobic Digester, Jacob Shaun Dustin

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The Induced Bed Reactor (IBR) was developed at Utah State University to apply high-rate anaerobic digestion techniques to high solids content substrates. This technology has been successfully implemented at full-scale multiple installations in the United States and Canada as a waste treatment and energy production technology, but the physical processes necessary to further optimize the system were not well understood.

Bench scale IBRs were operated as anaerobic digesters at 35°, 45°, and 55° C under three organic loading rates and three corresponding hydraulic retention times. Reactor performance was monitored at steady state for residence time distribution and substrate reduction.

The …

Water Allocation Challenges In Rural River Basins: A Case Study From The Walawe River Basin, Sri Lanka, D. K. Neelanga Weragala

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This dissertation evaluates the water allocation challenges in the rural river basins of the developing world, where demands are growing and the supply is limited. While many of these basins have yet to reach the state of closure, their water users are already experiencing water shortages. Agricultural crop production in rural river basins of the developing world plays a major role in ensuring food security. However, irrigation as the major water consumer in these basins has low water use efficiency. As water scarcity grows, the need to maximize economic gains by reallocating water to more efficient uses becomes important. …

Cooperative Remote Sensing And Actuation Using Networked Unmanned Vehicles, Haiyang Chao

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This dissertation focuses on how to design and employ networked unmanned vehicles for remote sensing and distributed control purposes in the current information-rich world. The target scenarios are environmental or agricultural applications such as river/reservoir surveillance, wind profiling measurement, and monitoring/control of chemical leaks, etc. AggieAir, a small and low-cost unmanned aircraft system, is designed based on the remote sensing requirements from environmental monitoring missions. The state estimation problem and the advanced lateral flight controller design problem are further attacked focusing on the small unmanned aerial vehicle (UAV) platform. Then the UAV-based remote sensing problem is focused with further flight …

Transmitter Localization Using Autonomous Robotic Swarms, Joshua S. Adams

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The purpose of this research is to design a proof of concept system that is capable of locating a hidden radio transmitter and to investigate methods of multi-agent formation control with a specific interest in the effectiveness of these methods on the overall objective of locating this transmitter. A system is proposed and developed in which autonomous agents work together to locate this transmitter and their responsiveness is analyzed while using formations based both on a behavioral system and a system derived from centroidal Voronoi tessellations. Many software adaptations to the existing MASnet program are required, as well as some …

Changes In Hybrid Poplar Endophytic Microbial Diversity In Response To Trichloroethylene Exposure, Jared S. Ervin

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Remediation of trichloroethylene (TCE) is a major priority for many contaminated sites all over the industrialized world including Hill Air Force Base, UT (HAFB). Phytoremediation as part of a cleanup strategy is an appealing option, and trees at HAFB have been studied to this end. Trees have also been used to delineate groundwater plumes because the passive uptake of organic contaminants by trees generally results in a direct relationship between tree and groundwater TCE concentrations if the trees are using the contaminated groundwater. However, the concentrations of plant-produced TCE metabolites can vary greatly. It was hypothesized that the endophytic microbial …

Transesterification And Recovery Of Intracellular Lipids Using A Single Step Reactive Extraction, Daniel R. Nelson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

A single-step, extractive reaction for extraction of lipids such as biodiesel components, omega-3 fatty acids, or other triglycerides from microbial cells was examined. Conventional methods for lipid extraction use toxic solvents, and require multiple steps and long processing times. When the goal is to produce fatty acid methyl esters or FAMEs, the extracted lipids are subjected to a separate transesterification reaction with simple alcohols in the presence of an acid or base catalyst. A simplified, single-step reactive extraction method can be applied that combines the sequential extraction followed by transesterification using acidified alcohols - a process known as in situ …

Decentralized Coordination Of Multiple Autonomous Vehicles, Yongcan Cao

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This dissertation focuses on the study of decentralized coordination algorithms of multiple autonomous vehicles. Here, the term decentralized coordination is used to refer to the behavior that a group of vehicles reaches the desired group behavior via local interaction. Research is conducted towards designing and analyzing distributed coordination algorithms to achieve desired group behavior in the presence of none, one, and multiple group reference states.

Decentralized coordination in the absence of any group reference state is a very active research topic in the systems and controls society. We first focus on studying decentralized coordination problems for both single-integrator kinematics and …

Nutrient Utilization From Anaerobic Digester Effluent Through Algae Cultivation, Shantanu Wahal

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Nutrients present in digested animal waste can be utilized for algae cultivation under suitable conditions. Algal growth, however, depends on the chemical forms and speciation of these nutrients. In this study a chemical equilibrium model was first used to describe nutrient speciation and predict conditions that enhance the solubility of nutrients in anaerobic digester effluent. Dilution with water and separation of large particulates greatly improved nutrient availability and light penetration - conditions favorable for algal cultivation. Algae growth was tested using three strains - Scenedesmus dimorphous (UTEX # 417), Chlorella vulgaris (UTEX# 265), and an algal isolate (designated as LLAI …

The Pursuit Of An Unequivocal Primary Representation, Delroy A. Brinkerhoff

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

A chief human characteristic is the desire and ability to change the world. Prior planning is crucial when those changes are complex and extensive, and require the cooperation of many people. To satisfy this need, many disciplines have developed specialized notations for representing the plans. Developers in one discipline, computer-based instruction, are burdened by the current need to use two separate notations. Instructional experts design the instruction and represent the design with a primary representation. The instruction described in a primary representation is easy to see, which makes the representation suitable for evaluation, communication, and enhancement. Programmers translate the primary …

The Hypericum Perforatum Herb As An Antimycobacterial Agent And Its Implications As An Additional Tuberculosis Medication, Trent W. Mortensen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

An immediate demand exists for new tuberculosis (TB) antibiotics due to the ever-increasing spread of drug-resistant strains. The drug-development process goes through four phases, the first (Phase 0) of which is to demonstrate and investigate drug effectiveness and toxicity. This research investigated the effectiveness of the Hypericum perforatum herb (commonly St. John's wort (SJW)) in its growth inhibition of mycobacteria and its viability effect on human lung cells.

Organic-solvent SJW extracts were effective at inhibiting every nonpathogenic genetically sequenced Mycobacterium isolate currently available (six isolates) in preliminary studies. Quantitative studies of five Mycobacterium isolates showed an order of concentration sensitivity …

Evaluation Method For Strategic Investments, Olabode Alabi

Department of Industrial and Management Systems Engineering: Dissertations, Theses, and Student Research

Real Options Analysis (ROA) has become a complimentary tool for engineering economics. It has become popular due to the limitations of conventional engineering valuation methods; specifically, the assumptions of uncertainty. Industry is seeking to quantify the value of engineering investments with uncertainty. One problem with conventional tools are that they may assume that cash flows are certain, therefore minimizing the possibility of the uncertainty of future values. Real options analysis provides a solution to this problem, but has been used sparingly by practitioners. This paper seeks to provide a new model, referred to as the Beta Distribution Real Options Pricing …

Electrophysiological Analysis In An Animal Model Of Dystonia, Kunal Chaniary

Theses and Dissertations

Dystonia is a movement disorder characterized by patterned, repetitive, and sustained muscle contractions that cause ineffective and often painful movements. The overall goal of this project was to understand the physiological mechanisms of dystonia in a rodent model as a basis for developing innovative treatments for secondary dystonias. The first half of the project was focused at developing essential techniques for systematically investigating the movement disorder in these animals. For achieving this, an innovative, multi-faceted approach was pursued starting with electromyographic (EMG) analysis for animal model validation, gait analysis for dystonia quantification, and development of a novel stereotaxic apparatus for …

Particle Image Velocimetry Measurements Of The Total Cavopulmonary Connection With Circulatory Flow Augmentation, Steven Chopski

Theses and Dissertations

This thesis project examined the interactive fluid dynamics between a blood pump and the univentricular Fontan circulation. 2-D particle image velocimetry (PIV) measurements were conducted on an idealized total cavopulmonary connection (TCPC) with an axial pump prototype in the inferior vena cava (IVC). Fluid velocity profiles were examined under various physiologic conditions for Fontan patients. The velocity profiles for all cases demonstrated the shunting of flow from the IVC toward the right pulmonary artery. A rotational component in the pump outflow was observed forcing flow to the periphery as compared to the flow profile without a pump present in the …

Development Of Mechanical Cardiovascular Assist Devices For Fontan Patients: Two Novel Approaches, Sonya Bhavsar

Theses and Dissertations

Few therapeutic alternatives exist for patients with a failing single ventricle physiology. To address this need, this thesis project investigated two new therapeutic alternatives, which sought to positively augment the Fontan hemodynamics. The first modality introduced a non-invasive method of external pressure application to the lower extremities. A clinical study (n=2) was conducted, and results indicated an increase in flow as a consequence to an increase in transmural pressure in the lower extremities. The second modality investigated a minimally invasive blood pump. Numerical analyses of the pump were performed to examine hydraulic performance under physiologic conditions. The pump produced pressure …

Ceas E-News 04.20.2010, College Of Engineering And Applied Sciences

College of Engineering and Applied Sciences News

WMU wins second overall in ASCE event

Optimization And Evaluation Of A Proportional Derivative Controller For Planar Arm Movement, Kathleen M. Jagodnik, Antonie J. Van Den Bogert

Mechanical Engineering Faculty Publications

In most clinical applications of functional electrical stimulation (FES), the timing and amplitude of electrical stimuli have been controlled by open-loop pattern generators. The control of upper extremity reaching movements, however, will require feedback control to achieve the required precision. Here we present three controllers using proportional derivative (PD) feedback to stimulate six arm muscles, using two joint angle sensors. Controllers were first optimized and then evaluated on a computational arm model that includes musculoskeletal dynamics. Feedback gains were optimized by minimizing a weighted sum of position errors and muscle forces. Generalizability of the controllers was evaluated by performing movements …

Optimality Principles For Model-Based Prediction Of Human Gait, Marko Ackermann, Antonie J. Van Den Bogert

Mechanical Engineering Faculty Publications

Although humans have a large repertoire of potential movements, gait patterns tend to be stereotypical and appear to be selected according to optimality principles such as minimal energy. When applied to dynamic musculoskeletal models such optimality principles might be used to predict how a patient's gait adapts to mechanical interventions such as prosthetic devices or surgery. In this paper we study the effects of different performance criteria on predicted gait patterns using a 2D musculoskeletal model. The associated optimal control problem for a family of different cost functions was solved utilizing the direct collocation method. It was found that fatigue-like …

Wright State University Celebration Of Research, Scholarship And Creative Activities 2010 Book Of Abstracts, Wright State University Office Of Undergraduate Research And Stemm Activities

Celebration of Undergraduate & Graduate Research, Scholarship, and Creative Activities Materials

The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's inaugural Celebration of Research, Scholarship and Creative Activities on April 16, 2010.

On Design Of Browser-Oriented Data Extraction System And The Plug-Ins, Jui-Yuan Su, Der-Johng Sun, I-Chen Wu, Lung-Pin Chen

Journal of Marine Science and Technology–Taiwan

Web data extraction systems currently not only extract data on web pages but also need to navigate to the target correctly. Most traditional web data extraction systems extract URLs directly from web pages, and then access next pages using the extracted URLs. This data extraction approach is herein called the URL-oriented data extraction approach in this paper. However, currently, more and more web pages use script functions, such as JavaScript, to access next pages and may hide URLs inside these functions, making it difficult to extract URLs. In order to solve this problem, a new data extraction approach, named the …

Estimation Of Manning Roughness Coefficients On Precast Ecological Concrete Blocks, Te-Hsing Chang, Shen-Ting Huang, Shinne Chen, Jun-Cheng Lai

Journal of Marine Science and Technology–Taiwan

Agricultural irrigation and drainage canals in Taiwan are generally constructed using concrete. Concrete is used for the safety of conveyance efficiency. It also reduced loss and is structurally safe. The irrigation ditches and soil revetments in Taiwan fitted with a strong concrete lining. The smooth nonporous concrete surface makes the biology perch difficult and causes a monotonous flow. For these reason, an artificial materials-precast ecological concrete blocks (PECBs) was developed in this research. This was done in order to modify both the traditional concrete lining and the natural field materials in canal construction. Precast ecological concrete blocks (PECBs) were tested …

Sustainable Portland: Implementation Series 3, New England Environmental Finance Center

Climate Change

This report is the third in a series of efforts by students at the Muskie School of Public Service, Community Planning and Development Master’s program, in a core class called “Sustainable Communities.” In this course students seek to understand principles of sustainability and how efforts to implement Sustainability programs can become more successful. The report assembles term papers students completed on particular efforts by municipalities, universities, and other groups to achieve sustainability goals. Students worked on each project in a service learning format with real world clients. They were asked to fashion their papers around lessons learned by other organizations …

46th Conference On Senior Engineering Design, College Of Engineering And Applied Sciences

Senior Engineering Design Conference

The 46th Conference on Senior Engineering Design Projects was held on April 20, 2010 at the College of Engineering and applied Sciences on the Parkview Campus of Western Michigan University. The college sponsors the conference to showcase the work of its graduating seniors, who are required to complete a capstone project that puts into practice what they have learned. Many of the projects are sponsored by business and industry.

Impulse, Dana Hess, Kyle Johnson, Eric Landwehr, Cindy Rickeman

Impulse (Jerome J. Lohr College of Engineering Publication)

College:
[Page] 2 The Hanson siblings: Karin and Erik Hanson, of Sioux Falls, find themselves in the spotlight outside their engineering environment and the focus of younger engineering students within the engineering community.
[Page] 4 Reviving a tradition: Engineering students are helping to make the Hobo Day parade the visual attraction it once was through a competitive float-building effort.
[Page] 6 Softball & engineering: Sisters Brittany, Brooke, and Brianna Postma are pretty good at figuring percentages, whether that be in the classroom or on the field.
[Page] 8 Engineering Expo leadership: ‘The Scrambler’ event helps launch Darin and Derek Waldner …

Section Abstracts: Biomedical And General Engineering

Virginia Journal of Science

Abstracts of the Biomedical and General Engineering Section for the 88th Annual Meeting of the Virginia Academy of Science, May 20-21, 2010, James Madison University, Harrisonburg, VA.

Ceg 479/679-01: Computer Animation, Thomas Wischgoll

Computer Science & Engineering Syllabi

No abstract provided.

Fpga Acceleration Of The Phylogenetic Likelihood Function For Bayesian Mcmc Inference Methods, Stephanie Zierke, Jason D. Bakos

Faculty Publications

Background
Likelihood (ML)-based phylogenetic inference has become a popular method for estimating the evolutionary relationships among species based on genomic sequence data. This method is used in applications such as RAxML, GARLI, MrBayes, PAML, and PAUP. The Phylogenetic Likelihood Function (PLF) is an important kernel computation for this method. The PLF consists of a loop with no conditional behavior or dependencies between iterations. As such it contains a high potential for exploiting parallelism using micro-architectural techniques. In this paper, we describe a technique for mapping the PLF and supporting logic onto a Field Programmable Gate Array (FPGA)-based co-processor. By leveraging …