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Hydrologic Efficiency In Water Conservation, L. Douglas James Jan 2012

Hydrologic Efficiency In Water Conservation, L. Douglas James

Reports

Introduction: The hydrologic cycle can be subdivided into three phases: 1)Humidity is transported within the atmosphere and becomes precipitation, and 2) Water moves downhill until eventually reaching the sea while all the time 3) Evapotranspiration returns exposed moisture to the atmosphere. During its movement, flowing water transports suspended sediments and dissolved minerals to reshape landforms and redistribute the mineral composition of the earth's surface throughout geologic time. It is during the second phase that flowing water can be diverted for uses that generally add to evaportranspiration (through consumptive use) and transport (through waste disposal). The water resources development that serves …


Energy Issues Affecting Corn/Soybean Systems: Challenges For Sustainable Production, Douglas L. Karlen, David Archer, Adam Liska, Seth Meyer Jan 2012

Energy Issues Affecting Corn/Soybean Systems: Challenges For Sustainable Production, Douglas L. Karlen, David Archer, Adam Liska, Seth Meyer

Adam Liska Papers

Quantifying energy issues associated with agricultural systems, even for a two-crop corn (Zea mays L.) and soybean (Glycine max [L.] Merr.) rotation, is not a simple task. It becomes even more complicated if the goal is to include all aspects of sustainability (i.e., economic, environmental, and social). This Issue Paper examines energy issues associated with and affecting corn/soybean rotations by first defining the size of the system from both a U.S. and global perspective and then establishing boundaries based on the Farm Bill definition of sustainability. This structured approach is essential to help quantify energy issues within corn/soybean …


Mononuclear Phagocyte Intercellular Crosstalk Facilitates Transmission Of Cell-Targeted Nanoformulated Antiretroviral Drugs To Human Brain Endothelial Cells, Georgette D. Kanmogne, Sangya Singh, Upal Roy, Xinming Liu, Joellyn Mcmillan, Santhi Gorantla, Shantanu Balkundi, Nathan Smith, Yazen Alnouti, Nagsen Gautam, You Zhou, Larisa Poluektova, Alexander Kabanov, Tatiana Bronich, Howard Gendelman Jan 2012

Mononuclear Phagocyte Intercellular Crosstalk Facilitates Transmission Of Cell-Targeted Nanoformulated Antiretroviral Drugs To Human Brain Endothelial Cells, Georgette D. Kanmogne, Sangya Singh, Upal Roy, Xinming Liu, Joellyn Mcmillan, Santhi Gorantla, Shantanu Balkundi, Nathan Smith, Yazen Alnouti, Nagsen Gautam, You Zhou, Larisa Poluektova, Alexander Kabanov, Tatiana Bronich, Howard Gendelman

Nebraska Center for Biotechnology: Faculty and Staff Publications

Despite the successes of antiretroviral therapy (ART), HIV-associated neurocognitive disorders remain prevalent in infected people. This is due, in part, to incomplete ART penetration across the blood–brain barrier (BBB) and lymph nodes and to the establishment of viral sanctuaries within the central nervous system. In efforts to improve ART delivery, our laboratories developed a macrophage-carriage system for nanoformulated crystalline ART (nanoART) (atazanavir, ritonavir, indinavir, and efavirenz). We demonstrate that nanoART transfer from mononuclear phagocytes (MP) to human brain microvascular endothelial cells (HBMEC) can be realized through cell-to-cell contacts, which can facilitate drug passage across the BBB. Coculturing of donor MP …


The Biological Systems Engineering Program In Nebraska 1895-2011, William Splinter Jan 2012

The Biological Systems Engineering Program In Nebraska 1895-2011, William Splinter

Department of Agricultural and Biological Systems Engineering: Faculty Publications

4. Preface: How Mechanization Has Impacted Food Production THE PIONEERS WHO ESTABLISHED THIS DEPARTMENT 8 Oscar Van Pelt Stout 10 Charles Russ Richards 12 J. Brownlee Davidson 14 Leon W. Chase FORMER FACULTY AND THEIR CONTRIBUTIONS 18 Laurence Froyd Seaton 20 Ivan D.Wood 22 Oscar W. Sjogren 23 Chauncey W. Smith 25 Elmer E. Brackett 27 Claud Kedzie Shedd 29 Ruby M. Loper 31 Lester F. Larsen 33 Lloyd W. Hurlbut 36 Rollin Schnieder 39 Howard D. Wittmuss 41 Deon Axthelm 46 Paul. E. Fischbach 48 Stuart O. Nelson 51 Kenneth von Bargen 56 John R. Davis 58 Robert W. …


Climate Change Impacts On Streamflow, Water Quality, And Best Management Practices For The Shell And Logan Creek Watersheds In Nebraska, M. W. Van Liew, S. Feng, T. B. Pathak Jan 2012

Climate Change Impacts On Streamflow, Water Quality, And Best Management Practices For The Shell And Logan Creek Watersheds In Nebraska, M. W. Van Liew, S. Feng, T. B. Pathak

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Improvements in the management of water, sediment, and nutrients under future climatic conditions are needed to ensure increased crop and livestock production to meet greater global needs and the future availability of water for competing demands and protection against adverse water quality impairments. This study determined the impacts of future climate change scenarios on streamflow, water quality, and best management practices (BMPs) for two watersheds in Nebraska, USA. The Soil and Water Assessment Tool (SWAT) was employed to simulate streamflow, sediment, total nitrogen (N) and total phosphorus (P) from the Shell Creek Watershed near Columbus, Nebraska and the Logan Creek …


Field Performance Evaluation Of A Ventilation System: A Swine Case Study, Jay D. Harmon, Michael C. Brumm, Larry D. Jacobson, Stephen H. Pohl, David R. Stender, Richard R. Stowell Jan 2012

Field Performance Evaluation Of A Ventilation System: A Swine Case Study, Jay D. Harmon, Michael C. Brumm, Larry D. Jacobson, Stephen H. Pohl, David R. Stender, Richard R. Stowell

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Swine finishing facility ventilation has become relatively complex and is often mismanaged as a system. One of the few ways to truly understand these systems is to spend time systematically going through the many components of the building and how they work as a system. To learn to help producers better, a team of university Extension specialists that included agricultural engineers and animal scientists spent an extended period carefully documenting conditions in a deep‐pit swine finishing building with two 1,000‐head rooms. Exhaust fans connected to the manure pit and wall fans were operated at various stages as a negative‐pressure ventilation …


Program And Proceedings: Nebraska Academy Of Sciences 1880–2012, 132nd Anniversary Year, One Hundred-Twenty-Second Annual Meeting Jan 2012

Program And Proceedings: Nebraska Academy Of Sciences 1880–2012, 132nd Anniversary Year, One Hundred-Twenty-Second Annual Meeting

Nebraska Academy of Sciences: Programs and Proceedings

Program

Applied Science and Technology

Biological and Medical Sciences

Nebraska Wesleyan University Health and Sciences Graduate School Fair

Aeronautics and Space Science, Poster Session

Maiben Memorial Lecture: "The Status of Nebraska's Native Aspen," "Buffalo" Bruce McIntosh, Western Nebraska Resources Council

Aeronautics

Anthropology

Biological and Medical Sciences

Chemistry and Physics

Collegiate Academy: Biology

Collegiate Academy: Chemistry and Physics

Earth Science

History/Philosophy of Science

Junior Academy, Senior High Competition

Teaching of Science and Math

Junior Academy, Junior High Competition


Novelty-Assisted Interactive Evolution Of Control Behaviors, Brian G. Woolley Jan 2012

Novelty-Assisted Interactive Evolution Of Control Behaviors, Brian G. Woolley

Electronic Theses and Dissertations

The field of evolutionary computation is inspired by the achievements of natural evolution, in which there is no final objective. Yet the pursuit of objectives is ubiquitous in simulated evolution because evolutionary algorithms that can consistently achieve established benchmarks are lauded as successful, thus reinforcing this paradigm. A significant problem is that such objective approaches assume that intermediate stepping stones will increasingly resemble the final objective when in fact they often do not. The consequence is that while solutions may exist, searching for such objectives may not discover them. This problem with objectives is demonstrated through an experiment in this …


Evolution Through The Search For Novelty, Joel Lehman Jan 2012

Evolution Through The Search For Novelty, Joel Lehman

Electronic Theses and Dissertations

I present a new approach to evolutionary search called novelty search, wherein only behavioral novelty is rewarded, thereby abstracting evolution as a search for novel forms. This new approach contrasts with the traditional approach of rewarding progress towards the objective through an objective function. Although they are designed to light a path to the objective, objective functions can instead deceive search into converging to dead ends called local optima. As a significant problem in evolutionary computation, deception has inspired many techniques designed to mitigate it. However, nearly all such methods are still ultimately susceptible to deceptive local optima because they …


Virtual Motion Camouflage Based Nonlinear Constrained Optimal Trajectory Design Method, Gareth Basset Jan 2012

Virtual Motion Camouflage Based Nonlinear Constrained Optimal Trajectory Design Method, Gareth Basset

Electronic Theses and Dissertations

Nonlinear constrained optimal trajectory control is an important and fundamental area of research that continues to advance in numerous fields. Many attempts have been made to present new methods that can solve for optimal trajectories more efficiently or to improve the overall performance of existing techniques. This research presents a recently developed bio-inspired method called the Virtual Motion Camouflage (VMC) method that offers a means of quickly finding, within a defined but varying search space, the optimal trajectory that is equal or close to the optimal solution. The research starts with the polynomial-based VMC method, which works within a search …


A Case-Crossover Study Of Laceration Injuries In Pork Processing, Lina Lander, Gary Sorock, Terry L. Stentz, Lynette Smith, Murray Mittleman, Melissa J. Perry Jan 2012

A Case-Crossover Study Of Laceration Injuries In Pork Processing, Lina Lander, Gary Sorock, Terry L. Stentz, Lynette Smith, Murray Mittleman, Melissa J. Perry

Department of Construction Engineering and Management: Faculty Publications

Objectives— The authors estimated the associations between transient risk factors and laceration injuries in workers at two meatpacking plants in the Midwest.

Methods— The case-crossover design was used to collect within-subject transient work task and personal-level exposure information. RRs of laceration injuries were estimated by comparing exposures during the ‘hazard’ period (just before the laceration injury) with exposures in the ‘control’ period (the previous workweek). Stratified analyses were utilized to estimate the effects of gender, ethnicity, training and the number of adjacent coworkers on each transient risk factor.

Results— The authors interviewed 295 meatpacking workers with laceration injuries (mean age …


Numerical Simulation And Experimentation Of Pulsatile Flows In Axisymmetric Arterial Models, Tadesse Gebreegziabher Jan 2012

Numerical Simulation And Experimentation Of Pulsatile Flows In Axisymmetric Arterial Models, Tadesse Gebreegziabher

Wayne State University Dissertations

ABSTRACT

NUMERICAL SIMULATION AND EXPERIMENTATION OF PULSATILE FLOWS IN AXISYMMETRIC ARTERIAL MODELS

by

TADESSE GEBREEGZIABHER

December 2011

Co-advisors: 1. Dr. Emmanuel Ayorinde 2. Dr. Trilochan Singh

Major: Mechanical Engineering

Degree: Doctor of Philosophy

The primary motivation for this dissertation is the fluid flow and structural response to unsteady blood flow in the human body. The research work is a synergistic merging of numerical simulation and experimentation. For the experiments, an all-encompassing, highly flexible experimental apparatus was designed and fabricated to facilitate a wide range of operating conditions, the range of which was chosen to accommodate mammalian cardiovascular system for both …


Artl@ S And Basart: A Loose Coupling Strategy For Digital Humanities, Sorin Matei Jan 2012

Artl@ S And Basart: A Loose Coupling Strategy For Digital Humanities, Sorin Matei

Cyber Center Publications

The core ARTL@S digital humanities
strategy is that of loosely coupling
resources, platforms, and use scenarios.
A number of sites will feed from
the same geodatabase (BasArt),
which will be enriched by users with
new content. Inspired by the Web 2.0
design principles, ARTL@S relies on
the BasArt API, which will enable an
ecosystem of sites to use primary
data to generate their own maps,
charts, and tables. A variety of economic
models will also be used to
support the site, from free to paybased.
User-generated content will be
monitored by data management and
curation techniques that will ensure
the …


Economic Modeling & Optimization Of A Region Specific Multi-Feedstock Biorefinery Supply Chain, William H. Faulkner Jan 2012

Economic Modeling & Optimization Of A Region Specific Multi-Feedstock Biorefinery Supply Chain, William H. Faulkner

Theses and Dissertations--Manufacturing Systems Engineering

The objective of this thesis is to include strategic and tactical level decisions into the biorefinery supply chain design for a specific region while comparing multiple conversion technologies and biomass feedstocks. The allocation of biomass feedstocks, products, and the respective supply chain configuration locations are determined while ensuring the regions monthly biomass availability and product market demand constraints are met. This research considers all actions required to bring the bio-based products to market from harvesting, storing, and processing the biomass to market distribution. Two different conversion technologies are chosen for comparison: one advanced conversion technology and one conventional technology. Potential …


Simulation Visualization Rhetoric And It's Practical Implications, D'An Knowles Ball, Andrew J. Collins Jan 2012

Simulation Visualization Rhetoric And It's Practical Implications, D'An Knowles Ball, Andrew J. Collins

Engineering Management & Systems Engineering Faculty Publications

Modeling and simulation has moved far beyond simple data representation into the world of visual communication over the past 15 years; ultimately, the acceptance of M&S within mainstream science and society will depend on the results that are produced visually. A simulation’s function is of primary importance to its end result, but it cannot be denied that the discipline of M&S now prizes fancy graphics to communicate. Rhetorical methodological decisions have the greatest impact on the end user, and considerations that bring visual rhetoric to modeling and simulation should be examined as a necessity to application. This paper will expose …


Acuta Enews January 2012 Vol. 41, No. 1 Jan 2012

Acuta Enews January 2012 Vol. 41, No. 1

ACUTA Newsletters

ln This lssue...

1 Board Approves Slate of Nominees

2 From the President: New Building Network Designs at BC............ .--.Joseph Harrington, Boston College

3 Nominate a Colleague for the ACUTA Ruth A Michalecki Leadership Award

4 Member Benefit of the Month: Monthly Newsletter Subscriptions

4 Today's ACUTA for Today's CIO ................. Keith Fowlkes, UVA Wise

5 ACUTA Webinar: The Challenges of Mobile Connectivity

5 Board Report............... Riny Ledgerwood, SDSU

6 Info Links.............. .....Randy Hayes, Univ. of Northern Iowa

7 How Transdisciplinarity Will Help Workers Thrive ...................James Fraleigh, Apollo Research Institute

8 Committee Corner

8 Thanks to Event Sponsors in 2011 …


Multiscale Modeling Of The Mouse Femur, Shannon Lisenbee Jan 2012

Multiscale Modeling Of The Mouse Femur, Shannon Lisenbee

All ETDs from UAB

This paper seeks to advance the knowledge base for bones and how they respond to mechanical stimuli through the use of multiscale modeling. First, a simple but effective approach for segmenting bone from computed tomography images using MATLAB is presented. Using edge detection and gradient operators to identify areas of bone within an image allows for much more accurate and consistent bone segmentation than simpler techniques like thresholding. This technique is applied to the femur of a female mouse for use in further modeling and testing. Next a representative volume element (RVE) for lamellar cortical bone is created based on …


Developing An Educational Video For Utilising An Oscilloscope In First Year Physics, Daniel Oswald, Graham Wild, Steven Hinckley Jan 2012

Developing An Educational Video For Utilising An Oscilloscope In First Year Physics, Daniel Oswald, Graham Wild, Steven Hinckley

Research outputs 2012

We report the development of a multimedia resource designed to aid undergraduate engineering and physics students in learning the operation and functions of a Digital Storage Oscilloscope.


Study Of Human Activity In Video Data With An Emphasis On View-Invariance, Nazim Ashraf Jan 2012

Study Of Human Activity In Video Data With An Emphasis On View-Invariance, Nazim Ashraf

Electronic Theses and Dissertations

The perception and understanding of human motion and action is an important area of research in computer vision that plays a crucial role in various applications such as surveillance, HCI, ergonomics, etc. In this thesis, we focus on the recognition of actions in the case of varying viewpoints and different and unknown camera intrinsic parameters. The challenges to be addressed include perspective distortions, differences in viewpoints, anthropometric variations, and the large degrees of freedom of articulated bodies. In addition, we are interested in methods that require little or no training. The current solutions to action recognition usually assume that there …


An Investigation Of The Relationship Between Visual Effects And Object Identification Using Eye-Tracking, Jonathan Rosch Jan 2012

An Investigation Of The Relationship Between Visual Effects And Object Identification Using Eye-Tracking, Jonathan Rosch

Electronic Theses and Dissertations

The visual content represented on information displays used in training environments prescribe display attributes as brightness, color, contrast, and motion blur, but considerations regarding cognitive processes corresponding to these visual features require further attention in order to optimize the display for training applications. This dissertation describes an empirical study with which information display features, specifically color and motion blur reduction, were investigated to assess their impact in a training scenario involving visual search and threat detection. Presented in this document is a review of the theory and literature describing display technology, its applications to training, and how eye-tracking systems can …


Ipad2 Logical Acquisition: Automated Or Manual Examination?, Somaya Ali, Sumaya Alhosani, Farah Alzarooni, Ibrahim Baggili Jan 2012

Ipad2 Logical Acquisition: Automated Or Manual Examination?, Somaya Ali, Sumaya Alhosani, Farah Alzarooni, Ibrahim Baggili

Electrical & Computer Engineering and Computer Science Faculty Publications

Due to their usage increase worldwide, iPads are on the path of becoming key sources of digital evidence in criminal investigations. This research investigated the logical backup acquisition and examination of the iPad2 device using the Apple iTunes backup utility while manually examining the backup data (manual examination) and automatically parsing the backup data (Lantern software-automated examination).The results indicate that a manual examination of the logical backup structure from iTunes reveals more digital evidence, especially if installed application data is required for an investigation. However, the researchers note that if a quick triage is needed of an iOS device, then …


Commentary And Interpretations Of Tagore’S 'Ode To Africa', Monish Ranjan Chatterjee Jan 2012

Commentary And Interpretations Of Tagore’S 'Ode To Africa', Monish Ranjan Chatterjee

Electrical and Computer Engineering Faculty Publications

This is a commentary/interpretation of Rabindranath Tagore's poem "Ode to Africa."


Alignment And Composition Of Laminin-Polycaprolactone Nanofiber Blends Enhance Peripheral Nerve Regeneration, Rebekah A. Neal, Sunil S. Tholpady, Patricia L. Foley, Nathan Swami, Roy C. Ogle, Edward A. Botchwey Jan 2012

Alignment And Composition Of Laminin-Polycaprolactone Nanofiber Blends Enhance Peripheral Nerve Regeneration, Rebekah A. Neal, Sunil S. Tholpady, Patricia L. Foley, Nathan Swami, Roy C. Ogle, Edward A. Botchwey

School of Medical Diagnostics & Translational Sciences Publications

Peripheral nerve transection occurs commonly in traumatic injury, causing deficits distal to the injury site. Conduits for repair currently on the market are hollow tubes; however, they often fail due to slow regeneration over long gaps. To facilitate increased regeneration speed and functional recovery, the ideal conduit should provide biochemically relevant signals and physical guidance cues, thus playing an active role in regeneration. To that end, laminin and lamininpolycaprolactone (PCL) blend nanofibers were fabricated to mimic peripheral nerve basement membrane. In vitro assays established 10% (wt) laminin content is sufficient to retain neurite-promoting effects of laminin. In addition, modified collector …


The Use Of An In Vitro 3d Melanoma Model To Predict In Vivo Plasmid Transfection Using Electroporation, Benadette Marrero, Richard Heller Jan 2012

The Use Of An In Vitro 3d Melanoma Model To Predict In Vivo Plasmid Transfection Using Electroporation, Benadette Marrero, Richard Heller

Bioelectrics Publications

A large-scale in vitro 3D tumor model was generated to evaluate gene delivery procedures in vivo. This 3D tumor model consists of a "tissue-like" spheroid that provides a micro-environment supportive of melanoma proliferation, allowing cells to behave similarly to cells in vivo. This functional spheroid measures approximately 1 cm in diameter and can be used to effectively evaluate plasmid transfection when testing various electroporation (EP) electrode applicators. In this study, we identified EP conditions that efficiently transfect green fluorescent protein (GFP) and interleukin 15 (IL-15) plasmids into tumor cells residing in the 3D construct. We found that plasmids …


Assessing The Therapeutic Effect Of 630 Nm Light-Emitting Diodes Irradiation On The Recovery Of Exercise-Induced Hand Muscle Fatigue With Surface Electromyogram, Dandan Yang, Xiaoying Wu, Wensheng Hou, Xiaolin Zheng, Jun Zheng, Yingtao Jiang Jan 2012

Assessing The Therapeutic Effect Of 630 Nm Light-Emitting Diodes Irradiation On The Recovery Of Exercise-Induced Hand Muscle Fatigue With Surface Electromyogram, Dandan Yang, Xiaoying Wu, Wensheng Hou, Xiaolin Zheng, Jun Zheng, Yingtao Jiang

Electrical & Computer Engineering Faculty Research

This paper aims to investigate the effect of light emitting diode therapy (LEDT) on exercise-induced hand muscle fatigue by measuring the surface electromyography (sEMG) of flexor digitorum superficialis. Ten healthy volunteers were randomly placed in the equal sized LEDT group and control group. All subjects performed a sustained fatiguing isometric contraction with the combination of four fingertips except thumb at 30% of maximal voluntary contraction (MVC) until exhaustion. The active LEDT or an identical passive rest therapy was then applied to flexor digitorum superficialis. Each subject was required to perform a re-fatigue task immediately after therapy which was the same …


Simulation-Based Performance Improvement Of A Defense Logistics Warehouse, Banu Y. Ekren, Gerald W. Evans, Sunderesh S. Heragu, John S. Usher Jan 2012

Simulation-Based Performance Improvement Of A Defense Logistics Warehouse, Banu Y. Ekren, Gerald W. Evans, Sunderesh S. Heragu, John S. Usher

12th IMHRC Proceedings (Gardanne, France – 2012)

Warehouses play a critical role in supply chains. They serve as a vital link between manufacturers and customers. In this study, we investigate performance of the largest warehouse (Eastern Distribution Center - EDC) of the Defense Logistics Agency (DLA) located in New Cumberland, PA and propose a near optimum design for the receiving area of the warehouse to improve its performance. First, we develop a simulation model of the system. Second, we interface an optimization model with the simulation in order to optimize the number of people working at the induction stations. In the optimization model, our goal is to …


Knowledge-Based Methods For Efficient Material Handling Equipment Development, Dirk Jodin, Christian Landschützer Jan 2012

Knowledge-Based Methods For Efficient Material Handling Equipment Development, Dirk Jodin, Christian Landschützer

12th IMHRC Proceedings (Gardanne, France – 2012)

This paper focuses on the Knowledge-based engineering (KBE) method and general Knowledge-based technologies for automated design of material handling products. As in vehicle and aerospace engineering this is a widespread technology, the authors try to introduce the main benefits of KBE for the material handling equipment design. The benefits of KBE, as faster and more accurate (safer) product development, customized products and knowledge of employees captured within a knowledge management system, let KBE hold many promising possibilities within, to deal with nowadays demands on engineering development, driven by cost reductions and time shortcuttings. The authors introduce the actual stage of …


The Theological Origins Of Engineering, Brad Kallenberg Jan 2012

The Theological Origins Of Engineering, Brad Kallenberg

Theology and Religious Studies Faculty Publications

Knowledge of our roots can sometimes help us figure out how we ought to proceed. Many claim that engineering began in ancient antiquity with the Egyptian pyramids, Archimedes' inventions, or the Roman aqueducts. Others give contemporary engineering a more recent history, tracing its origins to the Industrial Revolution or the Enlightenment. Yet what is often overlooked is the fact that contemporary engineering owes part of its identity to medieval monasticism.

The advantage of remembering this history is the bearing it has on the questions "What is engineering for?" and "How ought engineering be practiced?"

Michael Davis makes the claim that, …


Polymeric Nanocarriers For The Regional And Systemic Delivery Of Therapeutics To And Through The Lungs, Balaji Bharatwaj Jan 2012

Polymeric Nanocarriers For The Regional And Systemic Delivery Of Therapeutics To And Through The Lungs, Balaji Bharatwaj

Wayne State University Dissertations

The lungs are considered as one of the fastest portals of entry to the bloodstream and oral inhalation (OI) has long been accepted as the preferred mode of administration of therapeutics to the respiratory tract. However, despite its advantages, the lungs have been largely underutilized to target ailments not only of systemic relevance but also several other grave conditions including lung cancer and tuberculosis. Polymeric nanocarriers (PNCs) have several advantages over other drug delivery vehicles including sustained release of moieties, ease of cellular internalization and improved targeting, and hence hold the promise to greatly augment the potential of OI therapies. …


The Influence Of Membrane Cholesterol-Related Shear Stress Mechanosensitivity On Neutrophil Flow Behavior, Xiaoyan Zhang Jan 2012

The Influence Of Membrane Cholesterol-Related Shear Stress Mechanosensitivity On Neutrophil Flow Behavior, Xiaoyan Zhang

Theses and Dissertations--Biomedical Engineering

Hypercholesterolemia is a dominant risk factor for a variety of cardiovascular diseases and involves a chronic inflammatory component in which neutrophil activity plays a critical role. Recently, fluid shear stress mechanotransduction has been established as a control mechanism that regulates the activity of neutrophils by reducing the formation of pseudopods and the surface expression of CD18 integrins, thereby rendering these cells rounded, deformable, and non-adhesive. This is critical for maintaining a healthy circulation, because chronically activated neutrophils not only release excess cytotoxic and degradative agents but also exhibit a reduced efficiency to pass through the small vessels of the microcirculation …