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Evaluating Climate Change Effects In Two Contrasting Reservoirs Using Two-Dimensional Water Quality And Hydrodynamic Models, Oliver Obregon Mar 2012

Evaluating Climate Change Effects In Two Contrasting Reservoirs Using Two-Dimensional Water Quality And Hydrodynamic Models, Oliver Obregon

Theses and Dissertations

I analyzed and compared impacts from global climate change (GCC) and land use change to Deer Creek (United States) a temperate reservoir and Aguamilpa (Mexico), a tropical reservoir by using calibrated CE-QUAL-W2 (W2) water quality and hydrodynamic models based on field data over an extended time period. I evaluated and compared the sensitivity to predicted GCC and land use changes. I individually evaluated changes to air temperature (TAIR), inflow rates (Q), and nutrient loads (PO4-P and NO3-NO2-N) followed by analysis of worst case scenarios. I developed analysis methods using indexes to represent the total …


Losing The Lake: Development And Deployment Of An Educational Game, Joseph M. Vesco, Katie Gilgen, Anne Paine, Marissa Owens, Michael Nussbaum, Gale M. Sinatra, Sajjad Ahmad, Kent J. Crippen, Sergiu Dascalu, Frederick C. Harris Mar 2012

Losing The Lake: Development And Deployment Of An Educational Game, Joseph M. Vesco, Katie Gilgen, Anne Paine, Marissa Owens, Michael Nussbaum, Gale M. Sinatra, Sajjad Ahmad, Kent J. Crippen, Sergiu Dascalu, Frederick C. Harris

Civil and Environmental Engineering and Construction Faculty Research

When asked what the top three issues of the Las Vegas region were, the reply was “water, water, water!" This was the result of a survey done a few years ago of Las Vegas Valley TV anchors. The reason for this response is that sustainability of the urban environments requires sufficient water resources as does population growth. With the advent of global climate change, this resource is in danger. Water flow and mountainous ice packs are impacted by this change in climate there by impacting the amount of water the the region. This is compounded over time as the population …


Mathematical Framework For Early System Design Validation Using Multidisciplinary System Models, Bradley Jared Larson Mar 2012

Mathematical Framework For Early System Design Validation Using Multidisciplinary System Models, Bradley Jared Larson

Theses and Dissertations

A significant challenge in the design of multidisciplinary systems (e.g., airplanes, robots, cell phones) is to predict the effects of design decisions at the time these decisions are being made early in the design process. These predictions are used to choose among design options and to validate design decisions. System behavioral models, which predict a system's response to stimulus, provide an analytical method for evaluating a system's behavior. Because multidisciplinary systems contain many different types of components that have diverse interactions, system behavioral models are difficult to develop early in system design and are challenging to maintain as designs are …


Technical And Economic Assessment Of Adobe As The Primary Building Material On The Water Yield Of A Single Basin Solar Still, Nathan Daniel Manser Mar 2012

Technical And Economic Assessment Of Adobe As The Primary Building Material On The Water Yield Of A Single Basin Solar Still, Nathan Daniel Manser

USF Tampa Graduate Theses and Dissertations

It is estimated that only one percent of global freshwater is available to humans, with nearly three billion people living in water scarce conditions. Populations living in impoverished settings are particularly vulnerable to water related illnesses, with approximately 2.2 million people dying each year from to waterborne illnesses. This research uses modeling and field studies to assess the quantity, quality, and economics of distillate produced for drinking water from a brackish water source using two single-sloped, single-basin distillation reactors. The reactors were constructed from adobe and concrete in an arid rural community in San Luis Potosí, Mexico and tested from …


Overcoming Limitations Of Serial Audio Search, Isabela Cordeiro Ribeiro Moura Hidalgo Mar 2012

Overcoming Limitations Of Serial Audio Search, Isabela Cordeiro Ribeiro Moura Hidalgo

USF Tampa Graduate Theses and Dissertations

The typical approach for finding audio recordings, such as music and sound effects, in a database is to enter some textual information into a search field. The results appear summarized in a list of textual descriptions of the audio files along with a function for playing back the recordings. Exploring such a list sequentially is a time-consuming and tedious way to search for sounds. This research evaluates whether searching for audio information can become more effective with a user interface capable of presenting multiple audio streams simultaneously.

A prototype audio player was developed with a user interface suitable for both …


Methods For Enhancing Expression Of Secondary Cell Wall Cellulose Synthases In Plants, Chandrashekhar P. Joshi Mar 2012

Methods For Enhancing Expression Of Secondary Cell Wall Cellulose Synthases In Plants, Chandrashekhar P. Joshi

Michigan Tech Patents

Described are methods for making transgenic plants capable of expressing secondary cell wall cellulose synthases and methods of enhancing expression of secondary cell wall cellulose synthases in plants. Also described are plants produced by the methods. Plants comprising at least three exogenous polynucleotides encoding secondary cell wall cellulose synthases are also provided.


Effect Of Platinum Particle Size On The Sulfur Deactivation Of Hydrogenation, Lyndsey Michelle Baldyga Mar 2012

Effect Of Platinum Particle Size On The Sulfur Deactivation Of Hydrogenation, Lyndsey Michelle Baldyga

USF Tampa Graduate Theses and Dissertations

A large concern of the fossil fuel and renewable energy industries is the sulfur poisoning of catalysts. In the case of noble metals, such as platinum, it is seen that there is a size trend associated with the level of activity in the presence of sulfur. Smaller nanoparticles could be more tolerant due to sulfur surface vacancies. On the other hand, larger particles could have less deactivation because the sulfur is more attracted to the smaller particles and the sulfur molecules bind stronger to these smaller particles.

The size effect of sulfur deactivation was investigated by testing four sizes of …


The Creation Of A Robotics Based Human Upper Body Model For Predictive Simulation Of Prostheses Performance, Derek James Lura Mar 2012

The Creation Of A Robotics Based Human Upper Body Model For Predictive Simulation Of Prostheses Performance, Derek James Lura

USF Tampa Graduate Theses and Dissertations

This work focuses on the use of 3D motion capture data to create and optimize a robotic human body model (RHBM) to predict the inverse kinematics of the upper body. The RHBM is a 25 degrees of freedom (DoFs) upper body model with subject specific kinematic parameters. The model was developed to predict the inverse kinematics of the upper body in the simulation of a virtual person, including persons with functional limitations such as a transradial or transhumeral amputation. Motion data were collected from 14 subjects: 10 non-amputees control subjects, 1 person with a transradial amputation, and 3 persons with …


Design, Acnd Construction Of A Portable Artificial Insemination Chute, Chris Herrera Mar 2012

Design, Acnd Construction Of A Portable Artificial Insemination Chute, Chris Herrera

BioResource and Agricultural Engineering

This senior project report discusses the design, construction, and evaluation of a portable artificial insemination chute for the use of the Cal Poly Beef Department. The design was based on the suggested modifications from operators of several other chutes currently in use.

The main areas considered for the design were; Ergonomics, cattle safety, factors effecting maximum breeding conception rates, and Portability.

The breeding chute proved superior over traditional chutes in a variety of ways. Improvement occurred in the areas of consideration as follows, user operation was simplified, animal stress was decreased, and maximum breeding efficiency was obtained.


Rapid Battery Exchange For Electric Vehicles, Michael Cocchi, Adam Rizkalla Mar 2012

Rapid Battery Exchange For Electric Vehicles, Michael Cocchi, Adam Rizkalla

Computer Engineering

No abstract provided.


(Mu-Ctl-01-12) Towards Model Driven Game Engineering In Simsys: Requirements For The Agile Software Development Process Game, C. Shaun Longstreet, Kendra M. L. Cooper Mar 2012

(Mu-Ctl-01-12) Towards Model Driven Game Engineering In Simsys: Requirements For The Agile Software Development Process Game, C. Shaun Longstreet, Kendra M. L. Cooper

Center for Teaching and Learning Technical Reports

Software Engineering (SE) and Systems Engineering (Sys) are knowledge intensive, specialized, rapidly changing disciplines; their educational infrastructure faces significant challenges including the need to rapidly, widely, and cost effectively introduce new or revised course material; encourage the broad participation of students; address changing student motivations and attitudes; support undergraduate, graduate and lifelong learning; and incorporate the skills needed by industry. Games have a reputation for being fun and engaging; more importantly immersive, requiring deep thinking and complex problem solving. We believe educational games are essential in the next generation of e-learning tools. An extensible, freely available, engaging, problem-based game platform …


A Streamlined Strategy For Biohydrogen Production With Halanaerobium Hydrogeniformans, An Alkaliphilic Bacterium, Matthew B. Begemann, Melanie R. Mormile, Oliver C. Sitton, Judy D. Wall, Dwayne A. Elias Mar 2012

A Streamlined Strategy For Biohydrogen Production With Halanaerobium Hydrogeniformans, An Alkaliphilic Bacterium, Matthew B. Begemann, Melanie R. Mormile, Oliver C. Sitton, Judy D. Wall, Dwayne A. Elias

Biological Sciences Faculty Research & Creative Works

Biofuels are anticipated to enable a shift from fossil fuels for renewable transportation and manufacturing fuels, with biohydrogen considered attractive since it could offer the largest reduction of global carbon budgets. Currently, lignocellulosic biohydrogen production remains inefficient with pretreatments that are heavily fossil fuel-dependent. However, bacteria using alkali-treated biomass could streamline biofuel production while reducing costs and fossil fuel needs. An alkaliphilic bacterium, Halanaerobium hydrogeniformans, is described that is capable of biohydrogen production at levels rivaling neutrophilic strains, but at pH 11 and hypersaline conditions. H. hydrogeniformans ferments a variety of 5-and 6-carbon sugars derived from hemicellulose and cellulose …


Water Quality Monitoring In A Pilot Marine Integrated Aquaculture System, Alex W. Kruglick Mar 2012

Water Quality Monitoring In A Pilot Marine Integrated Aquaculture System, Alex W. Kruglick

USF Tampa Graduate Theses and Dissertations

Land based aquaculture systems are growing in popularity, and there is a drive to improve the efficiency of their energy and water systems for both economic and environmental benefit. Recirculating Aquaculture Systems (RAS) generally refer to systems that recycle their wastewater streams to be more or less a zero discharge facility. A more sustainable approach is emerging in the form of Integrated Aquaculture Systems (IAS) where maximum utility is realized from the various components so that fresh water use is reduced, water quality is improved, energy use is reduced, and new markets are created or fulfilled. Under a grant from …


Wheat Strip Effects On Nutrient Loads Following Variable Manure Applications, Chance Thayer, John E. Gilley, Lisa M. Durso, David B. Marx Mar 2012

Wheat Strip Effects On Nutrient Loads Following Variable Manure Applications, Chance Thayer, John E. Gilley, Lisa M. Durso, David B. Marx

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Vegetative filters have been found to significantly reduce nutrient loads in runoff. This study was conducted to: (1) evaluate the effects of a narrow wheat strip, varying manure application rates, and different overland flow rates on runoff nutrient loads following application of beef cattle manure; (2) determine the upper capacity of a narrow wheat strip to reduce nutrient loads by applying excessive amounts of manure; and (3) compare the effectiveness of narrow wheat strips and grass hedges in reducing runoff nutrient loads. A 1.4 m wide strip of actively growing winter wheat was located at the bottom of selected 0.75 …


Debris Propagation Due To A Space Vehicle Breakup At High Altitudes, Juan A. Alvarado Mar 2012

Debris Propagation Due To A Space Vehicle Breakup At High Altitudes, Juan A. Alvarado

Doctoral Dissertations and Master's Theses

Recently, there has been a surge of interest in the estimation of the extent of the airspace containing falling debris due to a space vehicle breakup. A precise computation of propagation of debris to the ground is not practical for many reasons. There is insufficient knowledge of the initial state vector, ambient wind conditions and the key parameters including the ballistic coecients. In addition, propagation of all debris pieces to the ground would require extensive computer time. In this thesis, a covariance propagation method is introduced for the estimation of debris propagation due to a space vehicle breakup. The falling …


Adding Ros Scavengers To Cold K+ Cardioplegia Reduces Superoxide Emission During 2 H Global Cold Cardiac Ischemia, Mohammed Aldakkak, David F. Stowe, James S. Heisner, Matthias L. Riess, Amadou K.S. Camara Mar 2012

Adding Ros Scavengers To Cold K+ Cardioplegia Reduces Superoxide Emission During 2 H Global Cold Cardiac Ischemia, Mohammed Aldakkak, David F. Stowe, James S. Heisner, Matthias L. Riess, Amadou K.S. Camara

Biomedical Engineering Faculty Research and Publications

We reported that the combination of reactive oxygen species (ROS) quenchers Mn(III) tetrakis (4-benzoic acid) porphyrin (MnTBAP), catalase, and glutathione (MCG) given before 2 hours cold ischemia better protected cardiac mitochondria against cold ischemia and warm reperfusion (IR)-induced damage than MnTBAP alone. Here, we hypothesize that high K+ cardioplegia (CP) plus MCG would provide added protection of mitochondrial bioenergetics and cardiac function against IR injury. Using fluorescence spectrophotometry, we monitored redox balance, ie reduced nicotinamide adenine dinucleotide and flavin adenine dinucleotide (NADH/FAD), superoxide (O2 •−), and mitochondrial Ca2+ (m[Ca2+]) in the left ventricular free …


Subclinical Photoreceptor Disruption In Response To Severe Head Trauma, Kimberly E. Stepien, Wanda M. Martinez, Adam M. Dubis, Robert F. Cooper, Alfredo Dubra, Joseph Carroll Mar 2012

Subclinical Photoreceptor Disruption In Response To Severe Head Trauma, Kimberly E. Stepien, Wanda M. Martinez, Adam M. Dubis, Robert F. Cooper, Alfredo Dubra, Joseph Carroll

Biomedical Engineering Faculty Research and Publications

Commotio retinae is a transient opacification of the retina due to outer retinal disruption occurring in a contrecoup fashion after blunt trauma.Histological studies in animals and humans after ocular blunt trauma have revealed that disruption occurs at the level of the photoreceptor outer segments and retinal pigment epithelium.Recent reports using optical coherence tomography (OCT) have shown detectable disruption at the level of the photoreceptor inner segment/outer segment junction and retinal pigment epithelium and that these changes may be reversible over time with restoration of normal outer retinal architecture.However, the resolution of existing OCT technology may not be sensitive enough to …


Enhanced Charge-Independent Mitochondrial Free Ca2+ And Attenuated Adp-Induced Nadh Oxidation By Isoflurane: Implications For Cardioprotection, Bhawana Agarwal, Amadou K.S. Camara, David F. Stowe, Zeljko J. Bosnjak, Ranjan K. Dash Mar 2012

Enhanced Charge-Independent Mitochondrial Free Ca2+ And Attenuated Adp-Induced Nadh Oxidation By Isoflurane: Implications For Cardioprotection, Bhawana Agarwal, Amadou K.S. Camara, David F. Stowe, Zeljko J. Bosnjak, Ranjan K. Dash

Biomedical Engineering Faculty Research and Publications

Modulation of mitochondrial free Ca2 + ([Ca2 +]m) is implicated as one of the possible upstream factors that initiates anesthetic-mediated cardioprotection against ischemia–reperfusion (IR) injury. To unravel possible mechanisms by which volatile anesthetics modulate [Ca2 +]m and mitochondrial bioenergetics, with implications for cardioprotection, experiments were conducted to spectrofluorometrically measure concentration-dependent effects of isoflurane (0.5, 1, 1.5, 2 mM) on the magnitudes and time-courses of [Ca2 +]m and mitochondrial redox state (NADH), membrane potential (ΔΨm), respiration, and matrix volume. Isolated mitochondria from rat hearts were energized with 10 …


The Latest Lessons Learned From Retrieval Analyses Of Ultra-High Molecular Weight Polyethylene, Metal-On-Metal, And Alternative Bearing Total Disc Replacements, Steven M. Kurtz, Jeffrey M. Toth, Ryan Siskey, Lauren Ciccarelli, Daniel Macdonald, Jorge Isaza, Todd Lanman, Ilona Punt, Marla Marla Steinbeck, Jan Goffin, André Van Ooij Mar 2012

The Latest Lessons Learned From Retrieval Analyses Of Ultra-High Molecular Weight Polyethylene, Metal-On-Metal, And Alternative Bearing Total Disc Replacements, Steven M. Kurtz, Jeffrey M. Toth, Ryan Siskey, Lauren Ciccarelli, Daniel Macdonald, Jorge Isaza, Todd Lanman, Ilona Punt, Marla Marla Steinbeck, Jan Goffin, André Van Ooij

Biomedical Engineering Faculty Research and Publications

Knowledge regarding the in vivo performance and periprosthetic tissue response of cervical and lumbar total disc replacements (TDRs) continues to expand. This review addresses the following 4 main questions: (1) What are the latest lessons learned from using polyethylene in large joints and how are they relevant to current TDRs? (2) What are the latest lessons learned regarding adverse local tissue reactions from metal-on-metal cobalt-chrome bearings in large joints and how are they relevant to current TDRs? (3) What advancements have been made in understanding the in vivo performance of alternative biomaterials, such as stainless steel and polycarbonate urethane, for …


Development Of A Standardized Method For Comparing Biomechanical Properties Of Various Sternal Closure Techniques, Ramzi P. Hawit Mar 2012

Development Of A Standardized Method For Comparing Biomechanical Properties Of Various Sternal Closure Techniques, Ramzi P. Hawit

Master's Theses

Background:

33.6% of all deaths in America are caused by cardiovascular disease. An estimated 82.6 million adults (>1 in 3) in America have some form of cardiovascular disease. There were over 400,000 bypass surgeries requiring open-heart surgery. Sternal dehiscence is associated with a morbidity rate of over 47% if mediastinitis supervenes. A rigid closure is required to avoid healing complications, and wire, plates, and bands are all used in an attempt to make a better closure. The purpose of this study it to compare multiple closures and validate a new testing method.

Methods:

Polyurethane foam blocks will be used, …


Damage To Mitochondrial Complex I During Cardiac Ischemia Reperfusion Injury Is Reduced Indirectly By Anti-Anginal Drug Ranolazine, Ashish K. Gadicherla, David F. Stowe, William E. Antholine, Meiying Yang, Amadou K.S. Camara Mar 2012

Damage To Mitochondrial Complex I During Cardiac Ischemia Reperfusion Injury Is Reduced Indirectly By Anti-Anginal Drug Ranolazine, Ashish K. Gadicherla, David F. Stowe, William E. Antholine, Meiying Yang, Amadou K.S. Camara

Biomedical Engineering Faculty Research and Publications

Ranolazine, an anti-anginal drug, is a late Na+ channel current blocker that is also believed to attenuate fatty acid oxidation and mitochondrial respiratory complex I activity, especially during ischemia. In this study, we investigated if ranolazine's protective effect against cardiac ischemia/reperfusion (IR) injury is mediated at the mitochondrial level and specifically if respiratory complex I (NADH Ubiquinone oxidoreductase) function is protected. We treated isolated and perfused guinea pig hearts with ranolazine just before 30 min ischemia and then isolated cardiac mitochondria at the end of 30 min ischemia and/or 30 min ischemia followed by 10 min reperfusion. We utilized …


Persistent Vascular Collagen Accumulation Alters Hemodynamic Recovery From Chronic Hypoxia, Diana M. Tabima, Alejandro Roldan-Alzate, Zhijie Wang, Timothy A. Hacker, Robert C. Molthen, Naomi C. Chesler Mar 2012

Persistent Vascular Collagen Accumulation Alters Hemodynamic Recovery From Chronic Hypoxia, Diana M. Tabima, Alejandro Roldan-Alzate, Zhijie Wang, Timothy A. Hacker, Robert C. Molthen, Naomi C. Chesler

Biomedical Engineering Faculty Research and Publications

Pulmonary arterial hypertension (PAH) is caused by narrowing and stiffening of the pulmonary arteries that increase pulmonary vascular impedance (PVZ). In particular, small arteries narrow and large arteries stiffen. Large pulmonary artery (PA) stiffness is the best current predictor of mortality from PAH. We have previously shown that collagen accumulation leads to extralobar PA stiffening at high strain (Ooi et al. 2010). We hypothesized that collagen accumulation would increase PVZ, including total pulmonary vascular resistance (Z0), characteristic impedance (ZC), pulse wave velocity (PWV) and index of global wave reflections (Pb/P …


Ablation Modeling Of A Solid Rocket Nozzle, Mark E. Ewing, Galen H. Richards, Micheal P. Iverson, Daron A. Isaac Feb 2012

Ablation Modeling Of A Solid Rocket Nozzle, Mark E. Ewing, Galen H. Richards, Micheal P. Iverson, Daron A. Isaac

Ablation Workshop

No abstract provided.


The Water Footprint Of Humanity, Arjen Y. Hoekstra, Mesfin Mekonnen Feb 2012

The Water Footprint Of Humanity, Arjen Y. Hoekstra, Mesfin Mekonnen

Daugherty Water for Food Global Institute: Faculty Publications

This study quantifies and maps the water footprint (WF) of humanity at a high spatial resolution. It reports on consumptive use of rainwater (green WF) and ground and surface water (blue WF) and volumes of water polluted (gray WF). Water footprints are estimated per nation from both a production and consumption perspective. International virtual water flows are estimated based on trade in agricultural and industrial commodities. The global annual average WF in the period 1996–2005 was 9,087 Gm3 ∕y (74% green, 11% blue, 15% gray). Agricultural production contributes 92%. About one-fifth of the global WF relates to production for export. …


Microgas Turbine Engine Characteristics Using Biofuel, Edmond Ing Huang Tan, William W. Liou Feb 2012

Microgas Turbine Engine Characteristics Using Biofuel, Edmond Ing Huang Tan, William W. Liou

The Hilltop Review

Aviation fuels commonly used today are extracted from the kerosene fraction of the crude oil that is distilled between the gasoline and the diesel. Crude oil is not renewable and the world oil reserve is generally believed to be on the decline. In 2006, 6.3% of the world's refinery production was used for aviation fuel (Nygren et. al., 2009). At an estimated rate of 3% increase of fuel demand per year, aviation use alone will consume the world fuel production by 2026. Therefore, there is a need for the aviation industry to reduce its dependence on fossil fuels and, perhaps, …


Impacts Of Changes In Land Use And Land Cover On Atmospheric Chemistry And Air Quality Over The 21st Century, S. Wu, L. J. Mickley, J. O. Kaplan, D. J. Jacob Feb 2012

Impacts Of Changes In Land Use And Land Cover On Atmospheric Chemistry And Air Quality Over The 21st Century, S. Wu, L. J. Mickley, J. O. Kaplan, D. J. Jacob

Michigan Tech Publications, Part 1

The effects of future land use and land cover change on the chemical composition of the atmosphere and air quality are largely unknown. To investigate the potential effects associated with future changes in vegetation driven by atmospheric CO 2 concentrations, climate, and anthropogenic land use over the 21st century, we performed a series of model experiments combining a general circulation model with a dynamic global vegetation model and an atmospheric chemical-transport model. Our results indicate that climate-and CO 2-induced changes in vegetation composition and density between 2100 and 2000 could lead to decreases in summer afternoon surface ozone of up …


Quantitative Cherenkov Emission Spectroscopy For Tissue Oxygenation Assessment, Johan Axelsson, Adam K. Glaser, David J. Gladstone, Brian W. Pogue Feb 2012

Quantitative Cherenkov Emission Spectroscopy For Tissue Oxygenation Assessment, Johan Axelsson, Adam K. Glaser, David J. Gladstone, Brian W. Pogue

Dartmouth Scholarship

Measurements of Cherenkov emission in tissue during radiation therapy are shown to enable estimation of hemoglobin oxygen saturation non-invasively, through spectral fitting of the spontaneous emissions from the treated tissue. Tissue oxygenation plays a critical role in the efficacy of radiation therapy to kill tumor tissue. Yet in-vivo measurement of this has remained elusive in routine use because of the complexity of oxygen measurement techniques. There is a spectrally broad emission of Cherenkov light that is induced during the time of irradiation, and as this travels through tissue from the point of the radiation deposition, the tissue absorption and scatter …


Fabrication Of Biocompatible, Vibrational Magnetoelastic Materials For Controlling Cellular Adhesion, Hal Holmes, Ee Lim Tan, Keat Ghee Ong, Rupak Rajachar Feb 2012

Fabrication Of Biocompatible, Vibrational Magnetoelastic Materials For Controlling Cellular Adhesion, Hal Holmes, Ee Lim Tan, Keat Ghee Ong, Rupak Rajachar

Michigan Tech Publications, Part 1

This paper describes the functionalization of magnetoelastic (ME) materials with Parylene-C coating to improve the surface reactivity to cellular response. Previous study has demonstrated that vibrating ME materials were capable of modulating cellular adhesion when activated by an externally applied AC magnetic field. However, since ME materials are not inherently biocompatible, surface modifications are needed for their implementation in biological settings. Here, the long-term stability of the ME material in an aqueous and biological environment is achieved by chemical-vapor deposition of a conformal Parylene-C layer, and further functionalized by methods of oxygen plasma etching and protein adsorption. In vitro cytotoxicity …


Biomolecular Mechanisms And Functional Characterization Of Nanomaterials In Programmed Cancer Cell Death For Potential Applications In Medicine, Biomedical Sciences, And Bioengineering, Md. Zakir Hossain Feb 2012

Biomolecular Mechanisms And Functional Characterization Of Nanomaterials In Programmed Cancer Cell Death For Potential Applications In Medicine, Biomedical Sciences, And Bioengineering, Md. Zakir Hossain

Theses and Dissertations

Cancer bionanotechnology is an interdisciplinary area of research in applied biosciences, biomedical engineering, and nano-medicine. Currently, apoptotic cell death inducers and regulators are considered to have significant potential for cancer therapy. The ability to escape apoptosis is one of the key properties of human cancer. Pancreatic cancer that has the highest fatality rates of all cancers is prompt to evade apoptosis. Nanomaterials like Ni NWs have various novel properties that could be very useful in bio-medical applications at the molecular and cellular levels. The overall objective of this research was to investigate the antiproliferative and apoptogenic properties of Ni NWs …


Fabrication And Characterization Of Synthetic Substrates For Use In Rigidity Cell Culture Studies Of Valvular Interstitial Cells For Aortic Valve Tissue Engineering, Alexander T. Leonard Feb 2012

Fabrication And Characterization Of Synthetic Substrates For Use In Rigidity Cell Culture Studies Of Valvular Interstitial Cells For Aortic Valve Tissue Engineering, Alexander T. Leonard

Chemical and Biological Engineering ETDs

More than 100,000 Americans each year undergo aortic valve (AV) replacement due to valve failure. An AV can become diseased, impairing the proper function of the valve. Common treatments for a defective valve are either replacement with a decellularized biologic or a synthetic valve. These treatments options are limited by short functional lifetime and thrombogenic surfaces. Tissue engineered heart valve will have the ability to integrate with the surrounding tissue as well as to repair and remodel. However, a greater understanding of valve cell biology is required to induce analogous tissue formation. A diseased valve is associated with stiffening of …