Digital Commons Network^™

Development Of A Supervisory Control Unit For A Series Plug-In Hybrid Electric Vehicle, Brian Neal Harries

Doctoral Dissertations and Master's Theses

A Series PHEV was chosen, as ERAU's entry into EcoCAR2 through a multidisciplinary architecture selection process. The series architecture was chosen for its mechanical feasibility, consumer acceptability and its performance on energy consumption simulations. The Series PHEV architecture was modeled using Matlab, Simulink, and dSPACE ASM tools, to create a plant model for controller development. A supervisory controller was developed to safely control the interactions between powertrain components. The supervisory control unit was tested using SIL and HIL methodologies. The supervisory controller was developed with an emphasis on fault detection and mitigation for safety critical systems. A power management control …

Modification And Application Of A Turbulence Response Analysis Method For Flexible Aircraft Configurations, Christie Jeanne Funk

Mechanical & Aerospace Engineering Theses & Dissertations

A software program and associated methodology to study gust loading on aircraft exists for a classification of geometrically simplified flexible configurations. This program consists of a simple aircraft response model with two rigid and three flexible symmetric degrees of freedom and allows for the calculation of various airplane responses due to a discrete one-minus-cosine gust as well as continuous turbulence. Simplifications, assumptions, and opportunities for potential improvements pertaining to the existing software program are first identified, then a revised version of the original software tool is developed with improved methodology to include more complex geometries, additional excitation cases, and output …

Analysis Of The Detection Of Organophosphate Pesticides In Aqueous Solutions Using Polymer-Coated Sh-Saw Sensor Arrays, Tian Newman

Master's Theses (2009 -)

The shear horizontal surface acoustic wave (SH-SAW) device was investigated as a micro-chemical sensor for the direct, rapid and in-situ monitoring of chemical contaminants in groundwater and wastewater. The chemical contaminants of interest are organo-phosphate-based compounds (parathion, parathion-methyl, and paraoxon). The polymers used as partially chemically selective coatings are 2,2’-diallylbisphenol A - 1,1,3,3,5,5-hexamethyltrisiloxane (BPA-HMTS), and 2,2’-diallylbisphenol A- polydimethylsiloxane (BPA-PDMS), polyepichlorohydrin (PECH). The experimental results indicate that the analyte/polymer interaction is a result of mass loading and viscoelastic changes in the polymer. BPA-HMTS, BPA-PDMS, and PECH have the highest to lowest sensitivity towards parathion, parathion-methyl, and paraoxon respectively. The polymers tested …

Development And Performance Of A Sparsity-Exploiting Algorithm For Few-View Single Photon Emission Computed Tomogrpahy (Spect) Reconstruction, Paul Arthur Wolf

Master's Theses (2009 -)

Single Photon Emission Computed Tomography (SPECT) provides noninvasive images of the distribution of radiotracer molecules. Dynamic Single Photon Emission Computed Tomography provides information about tracer uptake and washout from a series of time-sequence images. Stationary ring-like multi-camera systems are being developed to provide rapid dynamic acquisitions with high temporal sampling. Reducing the number of cameras reduces the cost of such systems but also reduces the number of views acquired, limiting the angular sampling of the system. Novel few-view image reconstruction methods may be beneficial and are being investigated for the application of dynamic SPECT. A sparsity-exploiting algorithm intended for few-view …

Design And Comparison Of Immersive Interactive Learning And Instructional Techniques For 3d Virtual Laboratories, Shuo Ren

Computational Modeling & Simulation Engineering Theses & Dissertations

Virtual reality (VR) as a learning environment plays an important role m engineering education. Utilizing the VR learning environment as a supplement to engineering-based laboratories is especially beneficial for students to prepare for the physical experiment and to grasp the experiment objectives and procedures. Such a methodology can also play a significant role in distance education.

This work presents the methodology design for the physical-to-virtual transformation of two undergraduate mechanical engineering laboratory experiments, namely the "Jet Impact Force on Vanes (Jet Force Lab)" and the "Elastic Test of a Beam in Pure Bending (Beam Bending Lab)" at Old Dominion University. …

Functional Integration In The Cortical Neuronal Network Of Conscious And Anesthetized Animals, Jeannette A. Vizuete

Dissertations (1934 -)

General anesthesia consists of amnesia, analgesia, areflexia and unconsciousness. How anesthetics suppress consciousness has been a mystery for more than one and a half centuries.

The overall goal of my research has been to determine the neural correlates of anesthetic-induced loss of consciousness. I hypothesized that anesthetics induce unconsciousness by interfering with the functional connectivity of neuronal networks of the brain and consequently, reducing the brain's capacity for information processing. To test this hypothesis, I performed experiments in which neuronal spiking activity was measured with chronically implanted microelectrode arrays in the visual cortex of freely-moving rats during wakefulness and at …

Pedaling-Related Brain Activation In People Post-Stroke: An Fmri Study, Nutta-On Promjunyakul

Dissertations (1934 -)

This study aimed to enhance our understanding of supraspinal control of locomotion in stroke survivors and its relationship to locomotor impairment. We focused mainly on the locomotor component of walking, which involves rhythmic, reciprocal, flexion and extension movements of multiple joints in both legs. Functional magnetic resonance imaging (fMRI) was used to record human brain activity while pedaling was used as a model of locomotion. First, we examined the spatiotemporal characteristics of hemodynamic responses recorded with fMRI and found that they were different in stroke survivors and control subjects. However, these differences were not substantial enough to require altering the …

Semi-Automatic Simulation Initialization By Mining Structured And Unstructured Data Formats From Local And Web Data Sources, Olcay Sahin

Computational Modeling & Simulation Engineering Theses & Dissertations

Initialization is one of the most important processes for obtaining successful results from a simulation. However, initialization is a challenge when 1) a simulation requires hundreds or even thousands of input parameters or 2) re-initializing the simulation due to different initial conditions or runtime errors. These challenges lead to the modeler spending more time initializing a simulation and may lead to errors due to poor input data.

This thesis proposes two semi-automatic simulation initialization approaches that provide initialization using data mining from structured and unstructured data formats from local and web data sources. First, the System Initialization with Retrieval (SIR) …

Orientation-Invariant Ecg-Based Virtual Pathology Stethoscope Tracking For Standardized Patient Heart Auscultation, Nahom B. Kidane

Computational Modeling & Simulation Engineering Theses & Dissertations

Cardiac auscultation (CA), the act of listening to the heart sounds, is a critical physician's skill that provides substantial information for diagnosing many cardiovascular disorders; therefore, competent training can be a key for accurate and reliable diagnosis. The teaching of CA has been an area of recognized importance since the inception of the stethoscope. However, recent changes in health-care, such as limited student access to patients and higher reliance on competing technologies have made it challenging to teach bedside CA techniques.

Over the past few decades, standardized patients (SPs), individuals trained to portray real patients, have been widely used for …

Soft Microenvironments Promote The Early Neurogenic Differentiation But Not Self-Renewal Of Human Pluripotent Stem Cells, Albert Keung, Prashanth Asuri, Sanjay Kumar, David Schaffer

Bioengineering

Human pluripotent stem cells (hPSCs) are of great interest in biology and medicine due to their ability to self-renew and differentiate into any adult or fetal cell type. Important efforts have identified biochemical factors, signaling pathways, and transcriptional networks that regulate hPSC biology. However, recent work investigating the effect of biophysical cues on mammalian cells and adult stem cells suggests that the mechanical properties of the microenvironment, such as stiffness, may also regulate hPSC behavior. While several studies have explored this mechanoregulation in mouse embryonic stem cells (mESCs), it has been challenging to extrapolate these findings and thereby explore their …

Application Of Seawinds Scatterometer Data To The Study Of Antarctic Icebergs, Keith Mitchell Stuart

Theses and Dissertations

Knowledge of iceberg location and size is important for safety reasons as well as for understanding many geophysical and biological processes. This dissertation analyzes large tabular icebergs in the Southern Ocean using the SeaWinds scatterometer. SeaWinds is a spaceborne radar designed to measure the microwave backscatter from the Earth's surface. Using resolution-enhancement techniques, backscatter measurements are processed into backscatter images in which icebergs can be observed. An iceberg detection methodology is formalized using daily scatterometer images. Radar profiles from common Antarctic scatterers are quantified and an iceberg detection methodology is formalized using daily scatterometer images. Iceberg positions are determined in …

Efficient Algorithms For Improving The Accuracy In Motifs Prediction, Jerlin C. Merlin

Master's Theses

Analysis of sequence homology has always played a major role in the understanding of biological factors such as protein domain identification, gene product relationships, and gene function determination. Short contiguous protein sequences that are conserved across proteins provide important information about such factors, and are of at most 15 residues in length. These segments of proteins are known as minimotifs. Identifying minimotifs has been of much use in the formulation of the hypothesis about the biological functions that otherwise might be uncharacterized. Mechanisms of motif predictions such as Minimotif Miner are widely used for predicting minimotifs. However, due to the …

Slides: Draft Power In Developing Country Agriculture--South Asia, Arjun Makhijani

2012 Energy Justice Conference and Technology Exposition (September 17-18)

Presenter: Dr. Arjun Makhijani, President, Institute for Energy and Environmental Research (IEER)

13 slides

Slides: Sources Of Electrical Energy For Those Who Are Remote And Poor, Frank Barnes

2012 Energy Justice Conference and Technology Exposition (September 17-18)

Presenter: Dr. Frank Barnes, Distinguished Professor, Electrical, Computer, and Energy Engineering, University of Colorado

24 slides

Slides: Session 3: Decision-Making And The Energy Poor, Andrew Yager

2012 Energy Justice Conference and Technology Exposition (September 17-18)

Presenter: Andrew Yager, United Nations Department of Economic and Social Affairs, Division for Sustainable Development

33 slides

The Bench Scientist's Guide To Statistical Analysis Of Rna-Seq Data, Craig R. Yendrek, Elizabeth A. Ainsworth, Jyothi Thimmapuram

Cyber Center Publications

RNA sequencing (RNA-Seq) is emerging as a highly accurate method to quantify transcript abundance. However, analyses of the large data sets obtained by sequencing the entire transcriptome of organisms have generally been performed by bioinformatics specialists. Here we provide a step-by-step guide and outline a strategy using currently available statistical tools that results in a conservative list of differentially expressed genes. We also discuss potential sources of error in RNA-Seq analysis that could alter interpretation of global changes in gene expression.

Ground Vehicle Navigation Using Magnetic Field Variation, Jeremiah A. Shockley

Theses and Dissertations

The Earth's magnetic field has been the bedrock of navigation for centuries. The latest research highlights the uniqueness of magnetic field measurements based on position due to large scale variations as well as localized perturbations. These observable changes in the Earth's magnetic field as a function of position provide distinct information which can be used for navigation. This dissertation describes ground vehicle navigation exploiting variation in Earth's magnetic field using a self-contained navigation system consisting of only a magnetometer and magnetic field maps. In order to achieve navigation, effective calibration enables repeatable magnetic field measurements from different vehicles and facilitates …

Novel Discretization Schemes For The Numerical Simulation Of Membrane Dynamics, Kyle F. Kolsti

Theses and Dissertations

Motivated by the demands of simulating flapping wings of Micro Air Vehicles, novel numerical methods were developed and evaluated for the dynamic simulation of membranes. For linear membranes, a mixed-form time-continuous Galerkin method was employed using trilinear space-time elements, and the entire space-time domain was discretized and solved simultaneously. For geometrically nonlinear membranes, the model incorporated two new schemes that were independently developed and evaluated. Time marching was performed using quintic Hermite polynomials uniquely determined by end-point jerk constraints. The single-step, implicit scheme was significantly more accurate than the most common Newmark schemes. For a simple harmonic oscillator, the scheme …

Characterizing Physical Properties Of Gas-Phase Biofilter Media, Guilherme Del Nero Maia, G. Tatiana Sales, George B. Day V, Richard S. Gates, Joseph L. Taraba

Biosystems and Agricultural Engineering Faculty Publications

Gas-phase biofiltration is an effective technology for reduction of odors and trace-gas contaminants. Significant contributions to the technical literature regarding the characterization of biofilter media have been generated in the past two decades. Nevertheless, the information produced has not been systematically organized. The objective of this study is to demonstrate and document methods for physical characterization of gas-phase compost biofilters (GPCB). The inclusion of moisture content, compaction, and particle size effects in the determination of media bulk density and porosity, field capacity, drying rate analysis, water sorption isotherms, and resistance to airflow is demonstrated. Results indicated that: (1) higher moisture …

Floating Wetland Systems For Nutrient Removal In Stormwater Ponds, Ni-Bin Chang, Martin Wanielista, Manoj Chopra

BMP Trains Research and Publications

Wet detention ponds are frequently used in stormwater management systems as part of a treatment train for attenuation of flow and removal of pollutants. Wet detention ponds designed and operated according to commonly used standards and specifications remove nutrients but the removal of nitrogen has remained low, about 30-40% concentration reduction on a yearly basis. A Floating Treatment Wetland (FTW) composed of selected plants suspended in a wet detention pond was proposed in this research to improve the removal of nutrients before discharge from a pond.

Maximal Force Characteristics Of The Ca2+-Powered Actuator Of Vorticella Convallaria, Sangjin Ryu, Matthew J. Lang, Paul Matsudaira

Department of Mechanical and Materials Engineering: Faculty Publications

The millisecond stalk contraction of the sessile ciliate Vorticella convallaria is powered by energy from Ca²⁺ binding to generate contractile forces of ~10 nN. Its contractile organelle, the spasmoneme, generates higher contractile force under increased stall resistances. By applying viscous drag force to contracting V. convallaria in a microfluidic channel, we observed that the mechanical force and work of the spasmoneme depended on the stalk length, i.e., the maximum tension (150–350 nN) and work linearly depended on the stalk length (~2.5 nN and ~30 fJ per 1 mm of the stalk). This stalk-length dependency suggests that motor units of …

Noise Impacts From Professional Dog Grooming Forced-Air Dryers, Peter M. Scheifele, Michael T. Johnson, David C. Byrne, John G. Clark, Ashley Vandlik, Laura W. Kretschmer, Kristine E. Sonstrom

Electrical and Computer Engineering Faculty Research and Publications

This study was designed to measure the sound output of four commonly used brands of forced-air dryers used by dog groomers in the United States. Many dog groomers have questions about the effect of this exposure on their hearing, as well as on the hearing of the dogs that are being groomed. Readings taken from each dryer at 1 meter (the likely distance of the dryer from the groomer and the dog) showed average levels ranging from 105.5 to 108.3 dB SPL or 94.8 to 108.0 dBA. Using the 90 dBA criterion required by the US Occupational Safety and Health …

Chronically Inadequate Sleep Results In Abnormal Bone Formation And Abnormal Bone Marrow In Rats, Carol A. Everson, Anne E. Folley, Jeffrey M. Toth

Biomedical Engineering Faculty Research and Publications

Insufficient sleep over long durations of the lifespan is believed to adversely affect proper development and healthful aging, although how this might become manifested is unknown. In the present study, rats were repeatedly sleep-restricted during 72 days to permit maladaptations to evolve, thereby permitting study. Densitometric and histomorphometric analyses were performed on harvested bone. In sleep-restricted rats, bone lined by osteoid was reduced 45-fold and osteoid thickness was decreased, compared with controls. This corresponded to a decrease in osteoblast number and activity. The percentage of bone lined by osteoclasts did not differ from that of controls. Plasma concentrations of an …

Multichannel Diffuse Optical Raman Tomography For Bone Characterization In Vivo: A Phantom Study, Jennifer-Lynn H. Demers, Scott C. Davis, Brian W. Pogue, Michael D. Morris

Dartmouth Scholarship

Raman spectroscopy is used to gather information on the mineral and organic components of bone tissue to analyze their composition. By measuring the Raman signal of bone through spatially offset Raman spectroscopy the health of the bone can be determined. We’ve customized a system with 8 collection channels that consist of individual fibers, which are coupled to separate spectrometers and cooled CCDs. This parallel detection system was used to scan gelatin phantoms with Teflon inclusions of two sizes. Raman signals were decoupled from the autofluorescence background using channel specific polynomial fitting. Images with high contrast to background ratios of Raman …

In Vitro Cytotoxicity And Skin Irritation Testing Of Antimicrobial Conjugated Electrolytes : Interactions With Mammalian Cells, Kristin N. Wilde

Chemical and Biological Engineering ETDs

An estimated 19,000 deaths and $3-4 billion in health care costs per year in the U.S. are attributed to methicillin-resistant Staphylococcus aureus (MRSA) infections. Certain cationic phenylene ethynylene (CPE)-based polymers (PPEs) and oligomers (OPEs) have been demonstrated to exhibit dark and light-activated antimicrobial activity. Envisioned applications of these CPEs include the fabrication of antimicrobial surfaces to reduce or prevent the spread of potentially untreatable strains of bacteria. Until recently, it was unknown if the polymers or oligomers would exhibit similar biocidal activity toward mammalian cells. This work examines the toxicity of CPEs to mammalian cells at three levels: cytoxicity testing …

The Effects Of Acetate Concentrations On Competition Between Microbial Populations In Enhanced Biological Phosphorus Removal From Wastewater, Yunjie Tu

Civil Engineering ETDs

Enhanced biological phosphorus removal (EBPR) is a popular modification of the activated sludge process, and has been studied and applied for decades. It was hypothesized that the bacteria responsible for EBPR, polyphosphate accumulating organisms (PAOs), have an advantage over their competitors, the glycogen accumulating organisms (GAOs). Because research EBPR systems have been primarily sequencing batch reactors (SBRs), which include rapid feed addition and relatively high substrate concentrations, while full scale systems often include complete mix reactors, which yield generally lower substrate concentrations due to instantaneous dilution of influent, evaluating this hypothesis has both fundamental and applied implications. The primary objectives …

Quantifying The Contribution Of Bank Storage Due To An Alteration In Stream Stage, Jeffrey Samson

Civil Engineering ETDs

The desire to control rivers to reduce risks of flooding while providing water storage for municipal and agricultural uses has resulted in the disconnection of rivers from their floodplains. An important and often neglected outcome of this detachment is the loss of a plethora of important ecosystem services. This research was focused on answering the following questions related to riparian groundwater storage (bank storage): 1) What is the time to saturation (maximum storage) and time to release of bank storage water as the result of a flood pulse that overbanks a portion of the floodplain?; 2) How does soil stratigraphy …

Role Of Glutathione In Lung Retention Of 99mtc-Hexamethylpropyleneamine Oxime In Two Unique Rat Models Of Hyperoxic Lung Injury, Said H. Audi, David L. Roerig, Steven Thomas Haworth, Anne V. Clough

Biomedical Engineering Faculty Research and Publications

Rat exposure to 60% O₂ for 7 days (hyper-60) or to >95% O₂ for 2 days followed by a 24-hour in room air (hyper-95R) confers susceptibility or tolerance, respectively, of the otherwise lethal effects of subsequent exposure to 100% O₂. The objective of this study was to determine if lung retention of the radiopharmaceutical agent ^99mTc-HMPAO (hexamethylpropyleneamine oxime) is differentially altered in hyper-60 and hyper-95R rats. Tissue retention of HMPAO is dependent on intracellular content of the antioxidant glutathione (GSH) and mitochondrial function. HMPAO was injected i.v. in anesthetized rats and planar images were acquired. …

Schmidtea Mediterranea Planaris As A Novel Animal Model For Investigating The Dynamics Of Nervous System Development In Fetal Alcohol Spectrum Disorder, Jesse Lowe

Theses and Dissertations

Fetal Alcohol Spectrum Disorder (FASD) is a prevalent developmental disease that is caused by excess in utero exposure to ethanol. The importance of timing and dosage of ethanol has been elucidated by previous investigations conducted with humans, rodents, and other model organisms, but challenges associated with determining functional deficiencies have necessitated the introduction of a novel animal model for investigating the dynamics of FASD. In this thesis, we propose that the freshwater flatworm planarian species, Schmidtea mediterranea, has the capability to fulfill this need. Planaria have the ability to completely regenerate fragments into intact, functional animals, and in these studies, …

Automation Of Landmark Selection For Rodent Brain Mri-Histology Registration Using Thin-Plate Splines, Ayan Sengupta

School of Computing: Dissertations, Theses, and Student Research

Image registration is the process of aligning two different images of the same object taken at different times, at different orientations or using different instruments. This is common in medical applications since multiple modalities are used to image different parts of the body. This is an important early step in many diagnostic procedures such as change detection, monitoring tumor or quantifying spread of a disease. The widely used landmark based registration approach is tedious, time consuming, inconsistent and error prone. Furthermore, the standard schemes based on rigid and affine transformation can only describe global geometric differences between the objects of …