Digital Commons Network^™

Application Of Computational Fluid Dynamics As A Simulation-Based Design Guide In A Microfluidic 3d Living Cell Array (3d Lca) Device, A.H. Rezwanuddin Ahmed

Dissertations and Theses

The use of computational fluid dynamics (CFD) as a tool in the aerodynamics and oil industry provides a reinforcement to efficiency in the design of aircrafts or for understanding the flow through pipes. A similar approach can be taken towards microfluidics, where traditionally devices have been designed based on experience or physiological replication, and a CFD simulation is shown post-manufacture to show the flow and diffusion patterns present. In this study, a reverse approach is suggested, by designing the device first in CFD and perform simulations on variations of alterable parameters to get insight on how the changing parameters affect …

Transport Pathway Across Hcaecs Uncer Convective Condtitions And The Role Of Apoptosis In Ldl Transport Through Hcaecs, Janpen Phupeerasupong

Dissertations and Theses

No abstract provided.

Drug Treatment Of Kidney Clip-Induced Hypertension In Rats; Peroxidase Tracer Spot Frequency In Rat Aorta After Chemically Induced Apoptosis, Simon Kleinbart

Dissertations and Theses

No abstract provided.

Selective Mercury Sequestration From A Silver/Mercury Cyanide Solution, Kristen L. Gabby

Dissertations, Master's Theses and Master's Reports - Open

Silver and mercury are both dissolved in cyanide leaching and the mercury co-precipitates with silver during metal recovery. Mercury must then be removed from the silver/mercury amalgam by vaporizing the mercury in a retort, leading to environmental and health hazards. The need for retorting silver can be greatly reduced if mercury is selectively removed from leaching solutions.

Theoretical calculations were carried out based on the thermodynamics of the Ag/Hg/CN- system in order to determine possible approaches to either preventing mercury dissolution, or selectively precipitating it without silver loss. Preliminary experiments were then carried out based on these calculations to determine …

Sustainable Energy Production In The United States: Life Cycle Assessment Of Biofuels And Bioenergy, Jiqing Fan

Dissertations, Master's Theses and Master's Reports - Open

The United States of America is making great efforts to transform the renewable and abundant biomass resources into cost-competitive, high-performance biofuels, bioproducts, and biopower. This is the key to increase domestic production of transportation fuels and renewable energy, and reduce greenhouse gas and other pollutant emissions.

This dissertation focuses specifically on assessing the life cycle environmental impacts of biofuels and bioenergy produced from renewable feedstocks, such as lignocellulosic biomass, renewable oils and fats. The first part of the dissertation presents the life cycle greenhouse gas (GHG) emissions and energy demands of renewable diesel (RD) and hydroprocessed jet fuels (HRJ). The …

A Bacterial Foraging Optimization Approach For Tuning Type-2 Fuzzy Logic Controller, Mohammad Kiani, Seyed Mohammad Ali Mohammadi, Ali Akbar Gharaveisi

Turkish Journal of Electrical Engineering and Computer Sciences

The type-1 fuzzy sets theory was proposed to handle uncertainty in control systems, but some cases showed some liabilities of type-1 fuzzy sets when faced with unpredictable disturbance and uncertainties. Therefore, type-2 fuzzy sets were introduced and extended while providing more degrees of freedom in designing criteria. The most important specification of type-2 fuzzy sets is the interval between a superior membership function and an inferior membership function, which is called the footprint of uncertainty. This paper presents a bacterial foraging optimization approach for optimizing the parameterized membership function. The above criterion is applied to an automatic voltage regulator system …

Cancer Risk Analysis By Fuzzy Logic Approach And Performance Status Of The Model, Atinç Yilmaz, Kürşat Ayan

Turkish Journal of Electrical Engineering and Computer Sciences

Cancer is the leading life-threatening disease for people in today's world. Although cancer formation is different for each type of cancer, it has been determined by studies and research that stress also triggers cancer types. Early precaution is very important for people who have not fallen ill yet with a disease like cancer that has a high mortality rate and expensive treatment. With this study, we expound that the possibility of developing such disease may be decreased and people could take measures against it. For the 3 cancer types selected as pilot work by introducing a fuzzy logic model, the …

Direct - Drive Permanent Magnet Synchronous Generator Design For Hydrokinetic Energy Extraction, Amshumaan Raghunatha Kashyap

Masters Theses

"Hydrokinetic turbines deliver lower shaft speeds when compared to both steam and wind turbines. Hence, a water wheel generator must operate at speeds as low as 150 - 600 rpm. This thesis describes a permanent magnet synchronous generator (PMSG) that was designed, built, and tested to serve a low speed hydrokinetic turbine. The design methodology was emphasized since designing an application specific generator poses various design and hardware construction issues. These are torque, speed, power and start-up requirements. This generator was built to operate without a speed increaser, implying very low speeds. FEA and performance results from the simulation done …

A Modification Of Freeze-Core Technology For Collecting Granular Fluvial Sediment Samples, David Charles Smith

Masters Theses

"The presence of coarse grained sediment can potentially reduce the effectiveness of conventional sampling methods in recovering fluvial sediments. A modification to freeze-core technology was used to collect fine grained sediments for the purpose of characterizing the extent of heavy metal contamination in fluvial deposits that contain significant amounts of coarse-grained material such as cobbles and boulders. This material greatly reduces the effectiveness of conventional sampling methods. This method uses 2.5-cm and 2.9-cm diameter by 30-cm long finned samplers that were mechanically- and hand-driven into the ground. The sediment is frozen to the outside of the sampler by injecting liquid …

Applications Of Antioxidant And Anti-Inflammatory Polymers To Inhibit Injury And Disease, David B. Cochran

Theses and Dissertations--Chemical and Materials Engineering

There is an undeniable link between oxidative stress, inflammation, and disease. Currently, approaches using antioxidant therapies have been largely unsuccessful due to poor delivery and bioavailability. Responding to these limitations, we have developed classes of polymer and delivery systems that can overcome the challenges of antioxidant and anti-inflammatory therapy. In our initial studies, nanoparticles of poly(trolox), a polymeric form of trolox, were surface-modified with antibodies. This modification allows for specific targeting to endothelial cells, affording controllable and localized protection against oxidative stress. We have shown these targeted nanoparticles bind, internalize, and provide protection against oxidative stress generation and cytotoxicity from …

Influence Of Surface Modification On Properties And Applications Of Complex Engineered Nanoparticles, Binghui Wang

Theses and Dissertations--Chemical and Materials Engineering

Complex engineered nanoparticles (CENPs) are being used on various applications. Their properties are different from those of neat nanoparticles. The dissertation explores these differences from four aspects: 1) Modify carbon nanomaterials’ inert surfaces and investigate the effect on thermal and rheological behavior of their dispersions; 2) Generate self-assembly bi-layer structure of oxide nanoparticles via surface modification; 3) Study interaction between lysozyme and different surface-charged ceria nanoparticles; 4) Investigate the biodistribution and transformations of CENPs in biological media.

An environment-friendly surface modification was developed to modify surfaces of carbon nanomaterials for increasing their affinity to non-polar fluid. It can offset formation …

Systems Simulation Using Promodel: An Online Teaching Method, Gustavo Sioni Bosoli

Masters Theses

This study was designed with the purpose to create an online method to deploy the concepts and practical knowledge necessary for the course System Simulation {TEC 5523) offered by Eastern Illinois University. The course is currently offered on a hybrid format, with part of it being ministered in the classroom and the remaining on the online environment. This research focused on creating a set of multimedia and step-by-step lessons aimed to substitute the part of the course that demands the students to be present in the classroom. These lessons were developed based on exercises from the textbook currently used for …

A Collaborative Social Computing Model For Transdisciplinary Problem Solving, Jerry Allen Higgs

All ETDs from UAB

The capacity to address and solve today's complex problems is becoming exceedingly more difficult because of the transdisciplinary nature of our current system of knowledge. Innovative solutions are no longer the by-products of centralized offices and laboratories. In fact, crafting solutions for truly complex problems requires a collaborative sharing of knowledge that transcends the artificial boundaries of departmentalized offices and research facilities. For decades, segmented information systems built on distributed platforms have kept transdisciplinary problem solving fragmented, without the ability to effectively share knowledge or data. This segmentation has stifled the progress of research reaching beyond the traditional boundaries of …

Estimation And Forecasting Of Air Handling Condensate Recovery Using Multiple Regression Analysis And Time-Series Autoregressive Models, Atul Nandkumar Kajale

All ETDs from UAB

According to the U.S. Drought Monitor (University of Nebraska at Lincoln, 2011), the majority of the Southeastern states are classified as being in a state of moderate, severe, extreme, and or exceptional drought. The northern part of Alabama including Jefferson County falls into the "abnormal" drought category. Due to the prevailing drought conditions in the Southeastern U.S. in the recent past, it is necessary to conserve water resources by using them as efficiently and responsibly as possible. The increasing population, socioeconomic developments, and industrialization could have significant impacts on the way we consume water today. There will be an imbalance …

Mesocorticolimbic Abnormalities In Schizophrenia: A Magnetic Resonance Spectroscopy And Diffusion Tensor Imaging Study, Meredith A. Reid

All ETDs from UAB

Schizophrenia is a complex, often debilitating chronic mental disorder that affects approximately 1% of people worldwide. Recently, there has been growing interest in identifying non-invasive biomarkers of schizophrenia. Understanding the molecular and structural mechanisms underlying clinical features of schizophrenia and patients' drug response is an important step in identifying biomarkers and potential targets for novel medications, treatment strategies, and interventions. The primary objective of this dissertation research was to use non-invasive magnetic resonance imaging techniques, specifically magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI), to examine the neurochemical and structural correlates of symptoms, cognition, and treatment response to antipsychotic …

Intramural Electrical Uncoupling During Long-Duration Ventricular Fibrillation In Rabbit, Trenika A. Madden

All ETDs from UAB

Ventricular fibrillation is a lethal cardiac arrhythmia which alters electrophysiological properties of the myocardium while concurrently inducing global ischemia and is associated with high mortality rates. Studies on the organization of long-duration ventricular fibrillation (LDVF) have shown that an endocardial to epicardial (i.e. transmural) activation rate gradient exists during ventricular fibrillation in canine and human myocardium; however, the underlying mechanism is unknown. This study tested the hypothesis that the activation rate gradient reflects heterogeneous changes in tissue electrical resistivity resulting in differential transmural electrical uncoupling of the ventricular myocardium. LDVF (>5min) was electrically induced in anesthetized, open-chest rabbits using …

Volumetric Contrast-Enhanced Ultrasound Imaging Of Vascular Perfusion In Renal Tissue, Marshall Joseph Mahoney

All ETDs from UAB

This research examines the ability of volumetric contrast-enhanced ultrasound (VCEUS) imaging to quantify kidney blood flow, with the potential to monitor changes in renal perfusion following acute kidney injury (AKI). Ultrasound (US) imaging of microbubble contrast agents allows for increased imaging isolation of the vasculature, creating a non-toxic approach to visualizing blood flow. VCEUS utilizes a series of planar ultrasound acquisitions that can be collected in real time to survey the vascularity of a volumetric region-of-interest. Through post-processing methods it is possible to quantify perfusion parameters such as peak intensity (IPK), time-to-peak intensity (TPK), wash-in rate (WIR), and area-under-curve (AUC). …

In Vitro Prevascularization Of 3d Tissue Constructs, Lauren Marshall

All ETDs from UAB

There is a need for more effective therapies to combat breast cancer. One reason for the inefficiency of therapeutics is that testing technologies currently employed in drug discovery and development are not reliable when transitioning drugs into human clinical trials. To supplement the currently used in vitro cell culture studies and in vivo animal studies, an in vitro three-dimensional breast tumor system has been suggested with integration of human cells, hydrogel biomaterials, 3D architecture, and endothelialized microchannels. Therefore, the objective of the thesis project, as an initial step in fabrication of the supplemental system for drug testing, is to fabricate …

In-Vivo Characterization Of Cone Photoreceptor Packing Density With Adaptive Optics Scanning Laser Ophthalmoscopy In Different Racial Groups, Ernesto Blanco Rivero

All ETDs from UAB

Cone photoreceptors are one of the two types of essential light sensitive cells that initiate the visual process in the human retina. A normal database of the cone density of healthy eyes may provide an important measure for diagnosing retinal diseases that cause photoreceptor loss, for monitoring disease progression, and for evaluating treatment out-come. Recent studies revealed that the foveal pit morphology, retina thickness, retinal nerve fiber layer (RNFL) thickness, and optic nerve head structure significantly correlated with racial background. We hypothesize that the cone density may be also modified by racial background. To test this hypothesis, I used a …

Utilizing A Hydroxyapatite-Binding Domain To Deliver Bone Regenerative Molecules To Hydroxyapatite And Allograft Bone To Enhance Osteogenesis, Bonnie Kathleen Culpepper

All ETDs from UAB

Hydroxyapatite (HA) makes up the mineral component of bone, and synthetic HA is commonly used to coat metal implants for use in dentistry and orthopedics. Additionally, allograft and synthetic HA are common alternatives to autograft bone, to circumvent the complications associated with a second surgery site. While both HA and allograft are known to be osteoconductive, osteoinductivity is limited. In this work, we developed methods for anchoring osteoinductive factors onto multiple types of HA biomaterials and human allograft bone, with the goal of enhancing their osteoregenerative potential. Specifically, a HA-binding domain, heptaglutamate (E7), modeled on bone-binding domains within native proteins, …

Ultrasound And Microbubbles: A Role In Cancer, Anna Sorace

All ETDs from UAB

Successful cancer treatment relies on the sensitivity to monitor cancer response to therapy and the ability to efficiently deliver drugs to the tumor. Cancer research has continuously improved patient outcomes over the last decades; however, it is still the second leading cause of death in the United States. It is essential to improve methods to progress all areas of cancer treatment, including monitoring and drug delivery. Ultrasound (US) is a popular clinical imaging modality due to its low levels of radiation, portability, and cost effective imaging. These advantageous characteristics have allowed for novel research advancements in the US field including …

Plga Nanospheres For Sustained Release Of Rifampicin, Alyssa Brianna Terry

All ETDs from UAB

Although Tuberculosis (TB) is often regarded as a disease of the past, it is still one of the leading killers of people worldwide. TB is caused by Mycobacterium tuberculosis, a bacterium that mostly infects the lungs but can also infect other organs throughout the body. One goal for TB treatment is to create a biocompatible, biodegradable drug delivery system that employs the use of multiple drugs while simultaneously relieving the patient from the burden of self-medicating. For this study, we optimized a procedure for making poly(lactic acid-co-glycolic acid) (PLGA) nanospheres and loading Rifampicin, one of the most potent and least …

The Impact Of Fine Sensor Spacing On Complex Tissue Impedance Spectra Measurements In Rabbit Ventricular Epicardium, Charlotte Mae Kent Waits

All ETDs from UAB

Our research group recently developed an instrumentation and signal processing approach that overcomes many of the obstacles associated with using small sensors to complete complex composite impedance (uCI) measurements, whose amplitude and phase depend upon the tissue's resistive and capacitive properties. The goal of this study was to test the feasibility of using smaller electrodes with finer separations than sizes traditionally employed in cardiac electrophysiologic studies with whole hearts to resolve uCI spectra in terms of magnitude (|uCI|) and phase (

The Investigation Of The Practice Of Frugal Innovation Across Cultures And The Introduction Of An Instructional Model For Streamlining The Design Process, Andres Efren Bolanos

Open Access Theses & Dissertations

The central objectives of this dissertation are to analyze frugal innovation, apply foundational methodologies that contribute to product design, and discover the important contextual information for successful development. This dissertation describes a systematic procedure in designing frugally innovated products. The institutional design will encompass environmental, social, and economic impacts into the entire products' life cycle. Also, a comparison is made between two developing nations' contextual factors to reveal the formulation of frugal innovation.

Solving Logistic System Design Problem Considering Various Biomass Feedstock Using Two Metaheuristic Optimization Methods, Jesusita Ibarra

Open Access Theses & Dissertations

Bioenergy has become an important source of energy; it can be used as an alternative to fossil fuel energy, and it offers significant potential to alleviate climate change by reducing greenhouse gas emissions caused by the burning of fossil fuels. The Energy Independence and Security Act decrees the use of 21 billion gallons of advanced biofuel including 16 billion gallons of cellulosic biofuels by the year 2022. It is easy to observe that biomass can make a considerable contribution meet the energy demands. On the other hand, the supply of sustainable energy is one of the main challenges that must …

Attitude Towards Green Warehousing In El Paso, Texas: An Exploratory Analysis, Lynda Jeanette Macias

Open Access Theses & Dissertations

The increasing reliance on fossil fuels by today's emerging economies has a profound implication on the sustainability of many warehousing and distribution logistical systems worldwide. This research attempts to fill the gap in current green warehousing literature by investigating how warehousing and distribution facilities view greener strategies as a way to increase operation efficiency through a stated preference approach. A survey instrument was developed, and the survey was conducted to identify warehousing characteristics, green practices, and current green views of warehouse managers in El Paso, Texas. The survey results found a balanced outlook within the environment and business needs. Companies …

High Fat Diet Induced Obesity In A Mouse Model For Colorectal Cancer, Kennerly Clinton Patrick

Theses and Dissertations

Obesity is widely correlated with the incidence of colorectal cancer (CRC). The exact mechanisms that link obesity to CRC risk have not yet been fully established, and only a limited number of animal models are available to study pathways involved in obesity-related colon carcinogenesis. The objective of this study was to determine the influence of HFD-induced obesity on AOM/DSS-mediated colorectal tumorigenesis, tumor proliferation, and symptom severity. Male C57BL/6 mice were fed a novel high fat diet, designed to mimic the standard American diet (12 % saturated fat & 28 % unsaturated fat), at 4 weeks of age until 16 weeks …

Supply Chain Optimization Of Blood Products, Serkan Gunpinar

USF Tampa Graduate Theses and Dissertations

Major challenges in the management of blood supply chain are related to the shortage and wastage of the blood products. Given the perishability characteristics of blood which can be stored up to a limited number of days, if hospitals and blood centers keep an excessive number of blood units on inventory, wastages may occur. On the other hand, if sufficient number of blood units are not stored on inventory, shortages of this resource may cause the cancellations of important activities and increase the fatality rates at hospitals. Three mathematical models have been developed with the goal to improve the efficiency …

Polymer-Based Fluidic Devices Integrated With Perforated Micro- And Nanopore Membrane For Study Of Ionic And Dna Transport, Junseo Choi

LSU Doctoral Dissertations

This study aims to develop a process, allowing a low-cost and high-throughput fabrication technique to produce freestanding polymer membranes having perforated micro- and nanopores, and also to design 3D micro/nanofluidic devices with the membrane, enabling a study of ions and DNA transport through nanopores. Technically, we have designed and fabricated high quality silicon stamp. Then, they have been used as molds for modified nanoimprint lithography that takes advantages of a sacrificial layer to obtain freestanding polymer membrane. This technique allows easy fabrication of large area, fully released polymer membranes containing perforated micro- and sub-micropores. The membrane with perforated micropores has …

Geometric Modeling And Optimization Over Regular Domains For Graphics And Visual Computing, Shenghua Wan

LSU Doctoral Dissertations

The effective construction of parametric representation of complicated geometric objects can facilitate many design, analysis, and simulation tasks in Computer-Aided Design (CAD), Computer-Aided Manufacturing (CAM), and Computer-Aided Engineering (CAE). Given a 3D shape, the procedure of finding such a parametric representation upon a canonical domain is called geometric parameterization. Regular geometric regions, such as polycubes and spheres, are desirable domains for parameterization. Parametric representations defined upon regular geometric domains have many desirable mathematical properties and can facilitate or simplify various surface/solid modeling and processing computation. This dissertation studies the construction of parameterization on regular geometric domains and explores their applications …