Digital Commons Network^™

Imaging Biomarkers For Prediction Of Treatment Response In Schizophrenia, Jennifer Ann Hadley

All ETDs from UAB

Schizophrenia affects approximately 1% of the population and is one of the top five causes of disability worldwide. Patient response to any particular drug is variable and currently unpredictable. Our overall goal is to identify imaging biomarkers that will distinguish patients with schizophrenia who will respond to an antipsychotic drug from those who will not. When considering potential biomarkers, it is important to note that schizophrenia is known to involve altered neuronal connections, thought to reflect pathologically relevant changes associated with the disease. We propose to utilize functional connectivity as a biomarker for treatment response to antipsychotic drugs in schizophrenia. …

Inkjet Bioprinting Of Solid Peroxides For Constructing Oxygen Generating Scaffolds To Improve Cells Viability And Growth Under Hypoxic Environment, Daniel Reyna Soriano

Open Access Theses & Dissertations

Tissue engineering has emerged as an interdisciplinary field to overcome current challenges for tissue repair or replacement in the human body. In essence, it proposes new medical therapies customized to match the biology of specific patients. The potential benefits offered by tissue engineering have driven scientific inquiry to make it a clinical reality.

One of the current challenges in tissue engineering is to provide oxygen supply to thick tissues as oxygen diffusion is limited to 100 - 200 µm layer of viable tissue. Engineered vascular conduits are applied in vitro, providing pre-vascularization to tissues; however, host anastomosis is still a …

Relating Admissibility Standards For Digital Evidence To Attack Scenario Reconstruction, Changwei Liu, Anoop Singhal, Duminda Wijesekera

Journal of Digital Forensics, Security and Law

Attackers tend to use complex techniques such as combining multi-step, multi-stage attack with anti-forensic tools to make it difficult to find incriminating evidence and reconstruct attack scenarios that can stand up to the expected level of evidence admissibility in a court of law. As a solution, we propose to integrate the legal aspects of evidence correlation into a Prolog based reasoner to address the admissibility requirements by creating most probable attack scenarios that satisfy admissibility standards for substantiating evidence. Using a prototype implementation, we show how evidence extracted by using forensic tools can be integrated with legal reasoning to reconstruct …

Novel Conditioning Protocols Focusing On Oxygen Manipulation To Enhance Stem Cell Transplantation, Brandon William Hanna

Theses and Dissertations

Musculoskeletal tissue engineering involves the creation of multiple tissue types that interact together to form a particular function related to motion and maintaining the body's frame. In order to create a fully functional musculoskeletal system, a concrete method for the creation of the different tissue types must first be completed. Of the different tissue components related to the function of a musculoskeletal system, these studies deal with preconditioning circumstances of stem cells that will differentiate into cartilage and bone. These studies also deal with methods for the creation of functional bone and cartilage to be combined for the creation of …

Evaluation Of Tissue-Engineered Tendon Enthesis Polymer Constructs, Joshua A. Bundy Bs, Mary Beth Wade Phd, Hitomi Nakao Md, Phillip Mcclellan Phd, Qing Yu Phd, Robin Jacquet-Childs Ms, William J. Landis Phd

Williams Honors College, Honors Research Projects

Both scientists and clinicians have proposed tissue engineering as the future of medicine. The possibilities for tissue engineering, that is, fabrication of tissues and organs in the laboratory and their translation to patients, appear to be endless, and many believe that this new approach in medicine will result in abolishing many common ailments, injuries, and congenital defects. Injuries to a tendon enthesis, the normal tissue connection between tendon and bone, are of particular concern to clinicians because of their frequency and failure to repair as a result of surgery. While these injuries may not be life threatening, they can certainly …

Impact Of Run-Off Coefficients On Urban Drainage Design, Ross O'Sullivan

Theses

This study assesses the impacts that runoff coefficients have on an urban drainage design. The first part of the report reviews how drainage design is carried out. This assesses the traditional hand calculations method, where eharts and graphs are used, versus the more modem approach of using a computer modelling system such as WinDes. Both approaches were reviewed, as both will be used to design drainage systems at a further stage in the project. The objective of this projeet is to see how runoff eoefficients impact on urban drainage design. The methodology used to determine this, is to test six …

Degradable Plastics And Their Potential To Affect Solid Waste Systems, Krista L. Thyberg, David J. Tonjes

Technology & Society Faculty Publications

Plastic waste forms a substantial part of municipal solid waste and has caused environmental concerns, particularly due to chemical contamination of the environment and effects from persistent litter. Plastics also complicate waste management processes, such as by having poor recovery rates through recycling, and causing contamination in composting operations. One potential means to address some of these challenges is through degradable plastics which, unlike conventional plastics, are designed to decompose at an accelerated rate in specific environments. Degradable plastics aim to address the end-of-life of plastic products and are intended to reduce the environmental impacts associated with their use and …

The Environmental Performance Of Biobased Resin Within Phenolic-Urethane Nobake Binders: A Feasibility Study, Ian David Morgan Williams

Dissertations and Theses @ UNI

The objectives of this research were to investigate the discovery and development of a biobased nobake binder resin for use within the foundry industry toward improved energy efficiency and environmental performance. The performance of polysaccharides within biobased resins was evaluated using industry-accepted methods and standards such as cure rate, tensile-strength development, and casting performance based upon step cone core results. Biobased nobake resins comprised of polysaccharide raw materials cure at a rate that is comparable to conventional nobake sand binders. Upon reaching stripping time, the development of biobased resin reveals a rapid increase in tensile strength, reaching 80% of its …

Systems Theory As The Foundation For Understanding Systems, Kevin Macg. Adams, Peggy T. Hester, Joseph M. Bradley, Thomas J. Meyers, Charles B. Keating

Engineering Management & Systems Engineering Faculty Publications

As currently used, systems theory is lacking a universally agreed upon definition. The purpose of this paper is to offer a resolution by articulating a formal definition of systems theory. This definition is presented as a unified group of specific propositions which are brought together by way of an axiom set to form a system construct: systems theory. This construct affords systems practitioners and theoreticians with a prescriptive set of axioms by which a system must operate; conversely, any set of entities identified as a system may be characterized by this set of axioms. Given its multidisciplinary theoretical foundation and …

Women In Science 2014, Clark Science Center's Summer Research Fellows Program

SURF Abstracts (Women in Science)

Women in Science 2014 summarizes research done by Smith College’s Summer Research Fellowship (SURF) Program participants. Ever since its 1967 start, SURF has been a cornerstone of Smith’s science education. In 2014, 150 students participated in SURF (141 hosted on campus and nearby eld sites), supervised by 61 faculty mentor-advisors drawn from the Clark Science Center and connected to its eighteen science, mathematics, and engineering departments and programs and associated centers and units. At summer’s end, SURF participants were asked to summarize their research experiences for this publication.

A Novel Waveform For Emergency Services Mobile Ad-Hoc Networks : The Link Layer Perspective, Sebastian Helmle

Theses

Existing wireless communication systems of emergency services mainly enable ordinary unicast or broadcast voice communications. The increasing demand for data services such as messaging, file transfer, maps, etc requires those long-range communication systems to provide higher data rates while maintaining robustness against link failures. In this thesis, various aspects of a link layer design specifically for narrowband mobile ad-hoc networks (MANETs) that are targeted at emergency services are investigated.

The major aspect of this thesis is the optimisation of a time division multiple access (TDMA) design considering both efficient and reliable multicast resource reservation. An approach to mathematically describe a …

Innovative Rts Technology For Dry Beneficiation Of Phosphate, Ahmed Sobhy, Daniel Tao

Mining Engineering Faculty Research & Creative Works

The Crago double flotation process is widely used for upgrading raw phosphate in Florida. However, it is a water-based physicochemical process and consumes a huge amount of water and chemicals and is not efficient to remove dolomite from phosphate. In addition, the final phosphate flotation concentrate often has a grade of 30-31% P2O5, which is below the BPL content of 75% (or 34.3% P2O5) required for making the animal feed grade phosphate. This study is performed to evaluate the potential and feasibility of the innovative rotary triboelectrostatic separator (RTS) as a dry phosphate beneficiation process. The RTS technology is characterized …

Neuromodulation Based Control Of Autonomous Robots On A Cloud Computing Platform, Cameron Muhammad

College of Graduate Studies: Theses & Dissertations

In recent years, the advancement of neurobiologically plausible models and computer networking has resulted in new ways of implementing control systems on robotic platforms. The work presents a control approach based on vertebrate neuromodulation and its implementation on autonomous robots in the open-source, open-access environment of robot operating system (ROS). A spiking neural network (SNN) is used to model the neuromodulatory function for generating context based behavioral responses of the robots to sensory input signals. The neural network incorporates three types of neurons- cholinergic and noradrenergic (ACh/NE) neurons for attention focusing and action selection, dopaminergic (DA) neurons for rewards- and …

Steganography Attack Based On Discrete Spring Transform And Image Geometrization, Qilin Qi, Aaron Sharp, Yaoqing Lamar Yang, Dongming Peng, Hamid Sharif

Department of Electrical and Computer Engineering: Faculty Publications

In order to prevent harmful secret information sharing by steganography, a new active-warden countermeasure approach against steganography is proposed in this paper. Differently from the other countermeasure approaches presented in current literature which need to have some knowledge of the steganographic algorithms to be attacked, our proposed method is a generic method which is independent of any particular steganography methods being utilized. In other words, our approach blindly attacks the steganography without any prior knowledge of the used algorithms or their existence. In general, the hidden information is embedded in a carrier by adjusting the coefficients of the audio or …

Fate Of Antimicrobials And Antimicrobial Resistance Genes In Simulated Swine Manure Storage, Stacey R. Joy, Xu Li, Daniel D. Snow, John Gilley, Bryan L. Woodbury, Shannon L. Bartelt-Hunt

School of Natural Resources: Faculty Publications

The behavior of three antibiotics (bacitracin, chlortetracycline, and tylosin) and two classes of antibiotic resistance genes (ARGs), tet and erm, were monitored in swine manure slurry under anaerobic conditions. First-order decay rates were determined for each antibiotic with half-lives ranging from1 day (chlortetracycline) to 10 days (tylosin). ARGs were monitored in the swine manure slurry, and losses of approximately 1 to 3 orders of magnitude in relative abundance were observed during the 40 day storage period. First-order degradation profiles were observed for chlortetracycline and its corresponding resistance genes, tet(X) and tet(Q). Tylosin was degraded to approximately 10% …

Yeast Pheromone Pathway Modeling Using Petri Nets, Stephen D. Scott, Abhishek Majumdar, Jitender S. Deogun, Steven D. Harris

School of Computing: Conference and Workshop Papers

Background: Our environment is composed of biological components of varying magnitude. The relationships between the different biological elements can be represented as a biological network. The process of mating in S. cerevisiae is initiated by secretion of pheromone by one of the cells. Our interest lies in one particular question: how does a cell dynamically adapt the pathway to continue mating under severe environmental changes or under mutation (which might result in the loss of functionality of some proteins known to participate in the pheromone pathway). Our work attempts to answer this question. To achieve this, we first propose a …

Effect Of Magnetic Nanoparticle Heating On Cortical Neuron Viability, Christopher J. Rivet, Yuan Yuan, Ryan J. Gilbert, Diana Andra Borca-Tasciuc

Chemical and Biochemical Engineering Faculty Research & Creative Works

Purpose: Superparamagnetic iron oxide nanoparticles are currently approved for use as an adjunctive treatment to glioblastoma multiforme radiotherapy. Radio frequency stimulation of the nanoparticles generates localized hyperthermia, which sensitizes the tumor to the effects of radiotherapy. Clinical trials reported thus far are promising, with an increase in patient survival rate; however, what are left unaddressed are the implications of this technology on the surrounding healthy tissue. Methods and materials: Amino silane-coated iron oxide nanoparticles suspended in culture medium were applied to chick embryonic cortical neuron cultures. Cultures were heated to 37 °C or 45 °C by an induction coil system …

Generalized Modal Expansion And Reduced Modal Representation Of 3-D Electromagnetic Fields, Qi I. Dai, Yat Hei Lo, Weng Cho Chew, Yang G. Liu, Li (Lijun) Jun Jiang

Electrical and Computer Engineering Faculty Research & Creative Works

A generalized modal expansion theory for investigating arbitrary 3-D bounded and unbounded electromagnetic fields is presented. When an inhomogeneity is enclosed with impenetrable boundaries, the field excited by arbitrary sources is expanded with a complete set of eigenmodes, which are classified into trapped modes and radiation modes. As the boundaries tend to infinity, trapped modes remain unchanged, while radiation modes form a continuum. To illustrate the theory, several real-life structures are investigated with a conformal finite-difference technique in the frequency domain. Perfectly matched layers (PMLs) are imposed at finite extent to emulate the unbounded problems. Numerical examples show that, only …

Analysis Of Bfsa Based Anti-Collision Protocol In Lf, Hf, And Uhf Rfid Environments, Varun Bhogal

UNF Graduate Theses and Dissertations

Over the years, RFID (radio frequency identification) technology has gained popularity in a number of applications. The decreased cost of hardware components along with the recognition and implementation of international RFID standards have led to the rise of this technology.

One of the major factors associated with the implementation of RFID infrastructure is the cost of tags. Low frequency (LF) RFID tags are widely used because they are the least expensive. The drawbacks of LF RFID tags include low data rate and low range. Most studies that have been carried out focus on one frequency band only. This thesis presents …

Gold-Magnetite Nanoparticle-Biomolecule Conjugates: Synthesis, Properties And Toxicity Studies, Akshay Pariti

Masters Theses

"This thesis study focuses on synthesizing and characterizing gold-magnetite optically active magnetic nanoparticle and its conjugation with biomolecules for biomedical applications, especially magnetic fluid hyperthermia treatment for cancerous tissue. Gold nanoparticles have already displayed their potential in the biomedical field. They exhibit excellent optical properties and possess strong surface chemistry which renders them suitable for various biomolecule attachments. Studies have showed gold nanoparticles to be a perfect biocompatible vector. However, clinical trials for gold mediated drug delivery and treatment studied in rat models identified some problems. Of these problems, the low retention time in bloodstream and inability to maneuver externally …

Evaluation Of Prosper For Modeling Long Lateral Gas Well Productivity In Toe Up, Toe Down, Horizontal Well Geometry, Abdussalam Mahmoud Mohamed

Masters Theses

"Most horizontal wells are not truly horizontal and may be drilled 'toe-up' or 'toe-down' to follow geological formations or in an attempt to keep the well from loading up. Challenges in directional drilling may also lead to horizontal gas wells with undulating wellbore profiles. This wellbore profile creates natural traps for heavy fluids in the lows and light fluid in the highs, which may result in chocked production. Hence, there is an interest in determining the best wellbore trajectory - toe-up, horizontal, or toe-down - for well unloading.

This study evaluates the capability of the well productivity software PROSPER to …

An Intelligent System For High Resolution Radar Systems, Janette C. Briones

Open Access Theses & Dissertations

Cognitive radio is a recent, novel approach that integrates machine perception software into wireless systems. The term cognitive radio was first used by Joe Mitola. The concept and the term cognitive radio quickly caught the attention and interest of many in the communications field. Cognitive radios are capable of making decisions and selecting or modifying the operating parameters of a radio. Given these capabilities, it is feasible to build a cognitive radar system as introduced by Simon Haykin in 2006. Cognitive radar, as described by Haykin, is an intelligent system that must be aware of its environment, uses prior knowledge, …

Natural Selectivity Of Nickel And Vanadium In Crude Oil, Olienka P. De La O Fernandez

Open Access Theses & Dissertations

Nickel and Vanadium have always been found in crude oil all around the world. The metal content is found mainly in porphyrin structures in the asphaltene fraction of the petroleum. In order to determine the reason for this natural preference, a set of experiments testing thermodynamics, kinetics, and other factors were performed. Candidate metalloporphyrins containing Vanadyl, Chromium, Iron, Nickel, Copper and Zinc were analyzed through chemical reactions characterized using Silica Column Chromatography, HPLC, MS and UV-Visible. Theoretical analysis of the stability of metalloporphyrins was conducted using DFT/NRLMOL for computational calculation. The analysis of all factors leads us to conclude that …

Development Of A Variable Stiffness Locally Adjustable And Repairable Low-Cost Energy Storage And Return Carbon Fiber Prosthetic Foot: A Feasibility Study, Joshua Scott Bowen

Open Access Theses & Dissertations

Background: Energy storage and return (ESAR) prosthetic feet were developed to improve the mobility and function of lower-limb amputees. Amputees in the Developing World amputees lack this technology. Most current Developing World prosthetic solutions do not adequately address the needs of active amputees and were not designed to pass international standard tests. Developing a low-cost, repairable, adjustable, energy storage and return prosthetic foot would close this technological gap and improve the mobility and function of active amputees. The goal of this research is to determine the feasibility of fabricating a low-cost, adjustable, ESAR, repairable prosthetic foot manufactured from carbon fiber …

Cell Releasing System Using Light Responsive Photovoltaic Devices, Mohammod Khairul Kabir Bhuyan

Open Access Theses & Dissertations

Tissue and organ regeneration via transplantation of cell bodies in-situ has become an emerging strategy in regenerative medicine. Injected or implanted cells must be available in large enough numbers and suitable delivery methods must be found especially when implantation into the affected tissue is not possible. In addition, better understanding of how to mitigate the inflammatory reactions and how to degrade the cell carriers are needed. Current cell-based therapies are limited to injection or implantation of cell suspensions or implantation of cell sheets. Development of alternative systems to obtain cell sheets or other functional cellular structures are required. We are …

An Explanatory And Comparative Analysis Of Freight Transportation In Eu And U.S. Highways, Luis Alberto Hernandez

Open Access Theses & Dissertations

This thesis provides resources for data collection regarding road freight transportation in the Unites States and the European Union, as well as an explanatory description of data available at each source. Afterwards, individual analysis of the current state of affairs of the highway freight transportation systems in U.S. and EU are performed. Thereafter, an explanatory and comparative analysis between the two land freight transportation systems is performed in terms of regulatory authorities and associations, trucks volume flow, freight weight and volume flow, major issues affecting the system, infrastructure funding sources, and major logistics hubs. Besides, a correlation analysis was performed …

Safety Measures For Trucks: A Comparison Between Eu And U.S., Jan Kapusta

Open Access Theses & Dissertations

Road transportation is playing an important role in almost all of the freight movements and contributes to the economy. It has the highest share in the modal division of transported goods. This situation is not about to change in next years to come. Therefore, it is necessary to change the current situation and create rules and regulations that would lead to decrease in number of accidents either in EU or in U.S. The goal of this research is to analyze selected parameters related to the safety of truck transportation in EU and in U.S. This thesis also identifies and compares …

Polycyclic Aromatic Hydrocarbon Degradation In Tidally Influenced Coastal Marsh Wetland Studied In Laboratory Mesocosm, Doorce S. Batubara

LSU Doctoral Dissertations

The compact mesocosm which was designed for a laboratory scale was used for the kinetic study of refractory organic compounds in a tidally influenced coastal marsh wetland soil. The tidal cycles were controlled pneumatically using an air chamber inside the mesocosm tank. Phenanthrene as the test compound showed that its degradation in the intertidal wetland soil was faster than that in the subtidal wetland soil. Oxygen resupply during the tidal cycles to the intertidal wetland soil would enhance the degradation. Comparison of degradation rates of phenanthrene (Phe), pyrene (Pyr), and benzo[e]pyrene (BeP) were also studied using the mesocosm. The degradation …

Synthesis And Characterization Of Novel Polyester Scaffolds From Sugarcane Industry By-Products For Use In Skin And Bone Tissue Engineering, Akanksha Kanitkar

LSU Doctoral Dissertations

The aim of this work was to synthesize non-toxic, biodegradable polyesters of aconitic acid, cinnamic acid and glycerol from by-products of the sugarcane industry as scaffolds for skin and bone tissue engineering. Utilizing the by-products, molasses and sugarcane bagasse, not only add value to the cane industry, but also paves path for synthesizing novel bio-based materials from the isolated specialty chemicals. Molasses contain an economically recoverable quantity of aconitic acid and its extraction was studied in detail as a part of this work. The yields of recovered aconitic acid varied from 25–69% depending on the extraction conditions. Under all the …

Less Is More: Long-Term In Vitro Exposure To Low Levels Of Silver Nanoparticles Provides New Insights For Nanomaterial Evaluation, Kristen K. Comfort, Laura K. Braydich-Stolle, Elizabeth I. Maurer, Saber M. Hussain

Chemical and Materials Engineering Faculty Publications

In view of the vast number of new nanomaterials (NMs) that require testing and the constraints associated with animal models, the majority of studies to elucidate nanotoxicological effects have occurred in vitro, with limited correlation and applicability to in vivo systems and realistic, occupational exposure scenarios.

In this study, we developed and implemented a chronic in vitromodel coupled with lower, regulatory dosages in order to provide a more realistic assessment of NM-dependent consequences and illuminate the implications of long-term NM exposure. When keratinocytes were exposed to 50 nm silver nanoparticles (Ag-NPs), we determined that chronically dosed cells operated …