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A Change Of Il-2 And Il-4 Production In Patients With Helicobactor Pylori Infection, X. G. Fan, Javed Yakoob, X. J. Fan, P. W. N. Keeling

Section of Gastroenterology

Helicobactor pylori is the most common cause of gastroduodenal inflammation. However, the exact immune pathogenesis is not fully understood. To look for evidence of the immunological mechanism in H. pylori associated disease, we measured cytokine interleukin-2 (IL-2) and IL-4 levels produced by peripheral blood lymphocytes (PBL) and gastric biopsies in 20 subjects with or without H. pylori infection. H. pylori can stimulate IL-2 and IL-4 production from PBL in H. pylori negative as well as H. pylori positive individuals. The spontaneous IL-2 production by PBL and gastric biopsies was greater (p < 0.0025, <0.001)in H. pylori negative individuals than that in H. pylori infected patients. Increased IL-4 levels from PBL in H. pylori infected patients were found in the presence of H. pylori (p < 0.0025). An increased spontaneous production of IL-4 from gastric biopsies was also observed in H. pylori infected patients (p < 0.025). In conclusion, an enhanced type 2 cytokine production was observed in H. pylori infected patients, which may be responsible for H. pylori chronic infection.

Structural Characterization Of A Novel Inhibitor Of Hiv Reverse Transcriptase (Hiv Rt), Greggory Jon Woitte

Chemistry & Biochemistry Theses & Dissertations

Human immunodeficiency virus (HIV) infections have become a leading cause of death among young people in the United States today. As the number of HIV infections increases, so too does the cost of treatment. Together, these numbers have prompted an increase in the development of pharmaceutical interventions. HIV reverse transcriptase (HIV RT) has become a suitable target for drug therapy because it is the sole enzyme responsible for HIV replication.

Fucoidan, a sulfated polysaccharide isolated from the brown algae Fucus vesiculosus, has been shown to block a variety of cell adhesion related events including metastasis. In addition, fucoidan has also …

The Kinetic Characterization Of Mutant L289p Of Recombinant Hiv-1 Reverse Transcriptase, Tryn Thomas Stimart

Chemistry & Biochemistry Theses & Dissertations

The Human Immunodeficiency Virus, type 1 (HIV-1) is the causative agent of the Acquired immunodeficiency Syndrome (AIDS). Currently, AIDS is the leading cause of death amongst young people in the United States. The large increase of HIV-1 infections over the past decade has spawned considerable research in fighting the spread of this disease. One area of intense HIV-1 research has focused on the enzyme Reverse Transcriptase (RT) which is an essential enzyme involved in the replication and life cycle of HIV-1. HIV-1 RT is composed of p66 and p51 subunits and is only active as a heterodimer in vivo. …

Acquired Immune Deficiency Syndrome, St Mary's University

President's Peace Commission - Programs

The President’s Peace Commission existed from 1984 to 2013 at St. Mary's University. The Commission fostered an ethical commitment to participate in the establishment of world peace and social justice.

This program is about acquired immune deficiency syndrome prevention.

Dynamic Diseases In Neurology And Psychiatry, John Milton, Deborah Black

WM Keck Science Faculty Papers

Thirty-two (32) periodic diseases of the nervous system are identified in which symptoms and/or signs recur. In 10/32, the recurrence of a symptom complex is one of the defining features of the illness, whereas in 22/32 oscillatory signs occur in the setting of an ongoing nervous system disorder. We discuss the possibility that these disorders may be dynamic diseases.

Dynamical Disease: Identification, Temporal Aspects And Treatment Strategies For Human Illness, Jacques Bélair, Leon Glass, Uwe An Der Heiden, John Milton

WM Keck Science Faculty Papers

Dynamical diseases are characterized by sudden changes in the qualitative dynamics of physiological processes, leading to abnormal dynamics and disease. Thus, there is a natural matching between the mathematical field of nonlinear dynamics and medicine. This paper summarizes advances in the study of dynamical disease with emphasis on a NATO Advanced Research Workshop held in Mont Tremblant, Quebec, Canada in February 1994. We describe the international effort currently underway to identify dynamical diseases and to study these diseases from a perspective of nonlinear dynamics. Linear and nonlinear time series analysis combined with analysis of bifurcations in dynamics are being used …

Ua66/4/2 Highlights, Vol. 1, No. 2, Wku Social Work

WKU Administration Documents

Newsletter created by and about the WKU Social Work department. Articles:

• New University Policy
• Westover, Lynn. Change is a Necessity of Life – Poem
• AIDS Education
• News from Association of Student Social Workers
• Association of Student Social Workers Potluck
• Phi Alpha News
• Field Student Spotlight – Ethan Browning & Amy Watson

An Overview Of The Effectiveness And Efficiency Of Hiv Prevention Programs, D. R. Holtgrave, Noreen L. Qualls, J. W. Curran, Ronald O. Valdiserri, Mary Guinan, William C. Parra

School of Public Health Faculty Research

Because of the enormity of the HIV-AIDS epidemic and the urgency for preventing transmission, HIV prevention programs are a high priority for careful and timely evaluations. Information on program effectiveness and efficiency is needed for decision-making about future HIV prevention priorities. General characteristics of successful HIV prevention programs, programs empirically evaluated and found to change (or not change) high-risk behaviors or in need of further empirical study, and economic evaluations of certain programs are described and summarized with attention limited to programs that have a behavioral basis. HIV prevention programs have an impact on averting or reducing risk behaviors, particularly …

Sharing Information Benefits The Meat Industry, Michael Paton

Journal of the Department of Agriculture, Western Australia, Series 4

Cronic health problems of livestock, seldom detected on farms, reduce the efficiency of abattoirs and returns to producers. But a major project providing information to producers from abattoirs is indicating how everyone could benefit from feedback.

Synergistic Effects Of Traumatic Head Injury And Apolipoprotein 4 In Patients With Alzheimer’S Disease, R. Mayeux, R. Ottman, Gladys E. Maestre, C. Ngai, M.-X. Tang, H. Ginsberg, M. Chun, B. Tycko, M. Shelanski

School of Medicine Publications

The apolipoprotein 4 allele increases the risk of Alzheimer’s disease (AD), but cerebral deposition of B-amyloid with age, a genetic mutation, or head injury may contribute to the pathogenesis of this disease. We examined the risks of AD associated with traumatic head injury and apolipoprotein 4 in 236 community-dwelling elderly persons. A 10-fold increase in the risk of AD was associated with both apolipoprotein 4a nd a history of traumatic head injury, compared with a two-fold increase in risk with apolipoprotein 4 alone. Head injury in the absence of an apolipoprotein 4 allele did not increase risk. These data imply …

Repellent And Acaricidal Properties Of Ocimum Suave Against Rhipicephalus Appendiculatus Ticks, Esther N. Mwangi, Ahmed Hassanali, Suliman Essuman, Edward Myandat, Lambert Moreka, Mark Kimondo

All Peer-Reviewed Publications

An oil extracted from the leaves of a tropical shrub Ocimum suave was found to repel as well as kill all stages of the tick Rhipicephalus appendiculatus. In an in vitro bioassay for the larvae, the LC50 of the oil in liquid paraffin was 0.024%. A 10% solution was found to kill all immatures and more than 70% of adults feeding on rabbits. Rabbits were protected for 5 days against attaching larvae using a 10% solution. Preliminary experiments undertaken with cattle kept in the field suggest that the oil may have potential in tick control, and a role in integrated …

Optimization Of The In Vitro Feeding Of Rhipicephalus Appendiculatus Nymphae For The Transmission Of Theileria Parva, S. M. Waladde, S. N. Mwaura, G. N. Njihia, F. N. Mwakima

All Peer-Reviewed Publications

An apparatus for artificial feeding of Rhipicephalus appendiculatus nymphae was modified to improve feeding performance. Heparinized blood was supplied above a treated artificial membrane while the ticks attached below on its undersurface. The feeding apparatus was incubated at 37 °C in an atmosphere of 3% CO2 concentration and a relative humidity of 75–80 °0. Under these conditions, 91 °0 of the engorged nymphae attained a mean weight of 6–11 mg, and an average of 93 °0 of those nymphae moulted into adults. When this system was used to feed nymphal ticks on blood infected with Theileria parva piroplasms, the mean …

Bulletin 4294 - Virus Diseases Of Lupins, Roger Jones

Bulletins 4000 -

Two virus diseases pose a serious threat to lupins. These are caused by cucumber mosaic virus (CMV), which induces diseases in narrow-leafed and yellow lupins, and bean yellow mosaic virus (BYMV), which infects all types of cultivated lupins. The effects of the viruses on lupin plants range from subtle colour changes and leaf distortion to leaf shedding, stunting and death. Seed production is decreased or prevented. There is no cure, but lupin crops can be managed to minimise both virus spread and its persistence from year to year.

CMV and BYMV occur within all tissues in the plant, but do …

Correlates And Consequences Of Early Initiation Of Sexual Intercourse, Ann L. Coker, Donna L. Richter, Robert F. Valois, Robert E. Mckeown, Carol Z. Garrison, Murray L. Vincent

CRVAW Faculty Journal Articles

This cross-sectional analysis of the 1991 CDC Youth Risk Behavior Survey explored factors associated with an early age at first sexual intercourse. Almost 18% of White males, 49% of Black males, 5% of White females and 12% of Black females were sexually active before age 13. Carrying a weapon to school, fighting, and early (< age 13) experimentation with cigarettes and alcohol were associated with early initiation of sexual activity for all four race and gender groupings. Those initiating sexual activity early had greater numbers of partners but were 50% less likely to use condoms regularly and were two-seven times more likely to have been pregnant or caused a pregnancy. Females who initiated sexual activity early were more likely to have had a sexually transmitted disease (STD). Interventions to postpone sexual activity need to be tailored to the ethnic and gender differences observed in these analyses. Interventions must begin before age 13 and should be comprehensive school-based efforts.

Characterization Of An Antiviral Agent Based On Nonionic Surfactants And It's Effects On Human Dermal Fibroblasts, Ji Young Li

Biological Sciences Theses & Dissertations

The AIDS ·pandemic has directed various research endeavors towards finding an appropriate method for eliminating all potentially infectious material within bone allografts before implantation into a recipient. To that effect, Panavirocide was conceived by Medicine and Applied Science·s, Inc. This compound, in which three nonionic surfactants serve as the active agents, has been shown to inactivate HIV-1 particles within blood and blood products. Because Panavirocide has never been used with allografts, the purpose of the present research was to characterize the nonionic surfactants for the putative alteration of the formulation by determining the critical micelle concentration values and to determine …

The Effect Of Cardiac Rehabilitation On Quality Of Life, Anxiety, And Self-Care In Coronary Artery Disease Patients, Susan Susskind Wilkinson

Theses & Dissertations

This study was designed to explore the effect of cardiac rehabilitation program participation on anxiety, quality of life, and self-care among coronary artery disease patients.

Major lifestyle changes are required after a person experiences an acute coronary event. Rehabilitation programs for coronary artery disease patients are designed to assist the patient with these lifestyle changes by altering the survivor's self-care patterns and improve long-term physical and psychological outcomes. By coordinating education, counseling, and exercise programs, the nurse can help individuals move toward a maximal physiological, psychological, social and vocational recovery. This study was designed to explore the effect of cardiac …

Question: What Is The Difference Between Volmax® And Proventil Repetabs®?, Jeffery A. Goad, Robert Andonian, Chris Chang, Greg Thompson

Pharmacy Faculty Articles and Research

Answer: There are noticeable differences between Volmax and Proventil Repetabs, two of the available oral forms of administering albuterol to patients suffering from asthma. These differences are discussed below.

Polyclonal Infections Due To Mycobacterium Avium Complex In Patients With Aids Detected By Pulsed-Field Gel Electrophoresis Of Sequential Clinical Isolates., Alexander M. Slutsky, Robert D. Arbeit, Thomas W. Barber, Josiah Rich, C Fordham Von Reyn

Dartmouth Scholarship

Invasive infection with organisms of the Mycobacterium avium complex (MAC) is common among patients with advanced human immunodeficiency virus infection. In previous studies, we analyzed multiple individual colonies of MAC isolated from specimens obtained at the same time and observed that 14 to 20% of patients are simultaneously infected with more than one strain. In this study, we examined sequential isolates from 12 patients with AIDS who had two or more MAC isolates available from clinical specimens collected more than 1 week apart; the intervals between the first and last specimens ranged from 8 to 192 (median, 46) days. For …

The Apolipoprotein Ε4 Allele In Parkinson's Disease With And Without Dementia, K. Marder, Gladys E. Maestre, L. Cote, H. Mejia, B. Alfaro, A. Halim, M. Tang, B. Tycko, R. Mayeux

School of Medicine Publications

The ϵ4 isoform of apolipoprotein E (Apo-E) may confer genetic susceptibility for familial and sporadic Alzheimer's disease (AD). Because dementia in AD and Parkinson's disease (PD) share many biologic and clinical features, we determined the Apo-E genotypes for 79 patients with PD, 22 of whom were demented, and for 44 age-matched healthy elderly controls from the same community. We hypothesized that if the dementia was similar to AD, there would be a higher allele frequency of apolipoprotein ϵ4 (Apoϵ4) in demented PD patients compared with nondemented PD patients and controls. The ϵ4 allele frequency for PD without dementia was 0.132, …

Review Of: Elizabeth M. Whelan, Toxic Terror: The Truth Behind The Cancer Scares, Sarah Redfield

RISK: Health, Safety & Environment (1990-2002)

Review of: Elizabeth M. Whelan, Toxic Terror: The Truth Behind the Cancer Scares (Prometheus Books 1993). Acknowledgements, appendix, figures, foreword by Norman F. Borlaug, index, notes tables. LC 92-34154; ISBN 0-87975-788-4. [476 pp. Cloth $26.95. 59 John Glenn Drive, Buffalo NY 14228-2197.]

Immunohistochemical Estrogen Receptor Determination In Human Breast Carcinoma: Correlation With Histologic Differentiation And Age Of The Patients, Shahid Pervez, S. Shaikh, F. Aijaz, S. A. Aziz, M. Naqvi, Sheema H. Hasan

Department of Pathology and Laboratory Medicine

An immunohistochemical assay for the measurement of estrogen receptor (ER) has been evaluated on 290 consecutive human breast biopsy and mastectomy specimens in the year 1992 at The Aga Khan University Hospital laboratories. Immunohistochemical localization of estrogen receptor on frozen/paraffin section was scored in a semi-quantitative fashion incorporating both the intensity and the distribution of specific staining. Histologic grading of the tumour was performed according to Bloom’s method. In this study, 21% of the tumours were estrogen receptor negative, 15% were weak positive, 25% intermediate positive and 39% strong positive. Fifty percent of the well differentiated tumours showed strong ER …

Periodontal Repair In Dogs : Part I : Evaluation Of The Natural Disease Model ; Part Ii : Eptfe Barrier Membranes Support Wound Stabilization And Enhance Bone Regeneration, James Marc Haney

Loma Linda University Electronic Theses, Dissertations & Projects

Animal models are frequently consulted for histometric analysis of reconstructive periodontal therapy. Statistical analysis of induced lesion defects and surgically created defects from our laboratory suggest defect size homogeneity is critical for the model to discriminate treatment effects. This study characterizes natural disease defects in beagle dogs. Buccal-lingual histologic sections from the 2nd, 3rd, and 4th mandibular premolar teeth (P2, P3, P4) from 6 aged beagle dogs with natural disease defects were evaluated for variation in defect height between pair matched tooth types, and jaw quadrants, as well as estimated confidence intervals for treatment differences between left and right pair …

Identification Of Risk Factors Associated With Pulpal Disease, Shelley R. Aronson

Loma Linda University Electronic Theses, Dissertations & Projects

A few studies have identified etiologic factors in pulpal disease, but little is known about the odds ratios of factors associated with pulpal disease. Odds ratios are well established measures of the effects of exposure to a particular outcome, and are comparisons of exposure to non-exposure in cases versus controls. The purpose of this study was to compare exposure of individual teeth to hypothesized risk factors in endodontic cases and in controls. This case-control study consisted of a chart review of 301 endodontic cases and 301 controls. Caries, types of restorations, and periodontal disease were the most significant factors. With …

The Media, Risk Assessment And Numbers: They Don't Add Up, Sharon M. Friedman

RISK: Health, Safety & Environment (1990-2002)

Professor Friedman argues that, for risks to be reported accurately, journalism educators must help their students understand science, numbers and statistics.

Patients As Subjects For Research: Ethical Dilemmas For The Primary Care Clinician-Investigator, Susan F. Slatkoff, Peter Curtis, Ann L. Coker

CRVAW Faculty Journal Articles

Background: Past studies suggested an association between human papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN). In 1987, University of North Carolina (UNC) Hospitals Family Practice Center clinicians were approached for a control population to study this association. Methods: One hundred fives patients attending the UNC Hospitals Neoplasia Clinic with biopsy-proven CIN 2 or 3 and 268 control patients attending the UNC Family Practice Center for a routine Papanicolaou smear were enrolled in this case-control study. Case and control patients consented to having an additional cervical specimen taken and to being interviewed. The cervical specimens were classified by the Southern blot …

Federal Black Lung Update, William S. Mattingly

West Virginia Law Review

No abstract provided.

Investigation Of Selenium Status In Hypo-, Hyper- And Euthyroid Children, Ping Sun

Chemistry & Biochemistry Theses & Dissertations

Recently, it has been reported that human type I iodothyronine deiodinase, an enzyme important in the conversion of T₄ to T₃ , is a selenoenzyme. Several studies have reported alterations in plasma selenium level in hypo- and hyperthyroid patients.

Using polarized Zeeman-effect atomic absorption spectroscopy, we measured selenium, zinc, copper and manganese concentrations in the plasma and/or red blood cells in children with or without thyroid disease being seen at the outpatient clinic at Children's Hospital of the King's Daughters. Children with thyroid disease were subdivided into untreated, treated and nonresponsive groups. Data were analyzed using Student's t-test …

Conjoined Twins - A Review Of Literature With Two Case Studies, Naaeem Uz-Zafar Khan, Nadeem Ullah Khan, Khalid Matin, Adnan Zaidi

Department of Emergency Medicine

Two cases of conjoined twins have been reported. A review of literature is given.

The Amino-Terminal Functions Of The Simian Virus 40 Large T Antigen Are Required To Overcome Wild-Type P53-Mediated Growth Arrest Of Cells., Robin S. Quartin, Charles N. Cole, James M. Pipas, Arnold J. Levine

Dartmouth Scholarship

High levels of the p53 tumor suppressor protein can block progression through the cell cycle. A model system for the study of the mechanism of action of wild-type p53 is a cell line (T64-7B) derived from rat embryo fibroblasts transformed by activated ras and a temperature-sensitive murine p53 gene. At 37 to 39 degrees C, the murine p53 protein is in a mutant conformation and the cells actively divide, whereas at 32 degrees C, the protein has a wild-type conformation and the cells arrest in the G1 phase of the cell cycle. Wild-type simian virus 40 large T antigen and …

Dynamics Of Host Blood Effects In Glossina Morsitans Sspp. Infected With Trypanosoma Congolense And T. Brucei, Reardon O. Olubayo, Steve Mihok, Eli Munyoki, Leonard H. Otieno

All Peer-Reviewed Publications

The pattern of infection in Glossina morsitans morsitans and G. m. centralis membrane-fed on eland, buffalo or goat blood mixed with Trypanosoma congolense or T. brucei was studied from day 1 to day 10. Tsetse were initially permissive vectors, with most flies harbouring infections of 104-105 parasites on day 3. However, after a second blood meal on day 3, flies cleared many infections with G. m. morsitans clearing more infections than G. m. centralis. Infective feeds of goat blood consistently increased final infection rates by limiting the number of infections lost between days 3 and 6. In further experiments with …