Digital Commons Network^™

State Social Benefit Schemes For Women In Continuity Of Psychiatric Care: A Case Report, Mathumitha A, Kishor M. Manohar Rao Professor

Digital Journal of Clinical Medicine

Mental health disorders are a major global public health challenge. The disorders affect over a billion people worldwide, while depressive and bipolar spectrum disorders also contribute substantially to disability and reduced quality of life. According to the World Health Organization, major depression alone affects more than 300 million people globally and is considered a leading cause of years lived with disability. Beyond clinical morbidity, mental illnesses exert a profound economic impact, with depression and anxiety accounting for an estimated USD 1 trillion annually in lost productivity worldwide, while the overall global economic burden of mental disorders is projected to reach …

Dietary Micronutrients And The Risk Of Gestational Diabetes: Evidence From A Tertiary Care Setting In India, Sujatha Mahadevarao Premnath, Moneesh Sivasoupramaniane, Maghida S

Digital Journal of Clinical Medicine

Background: Gestational Diabetes Mellitus (GDM) is a significant health concern in India, affecting nearly 22.4% of pregnant women. While macronutrient roles are well explored, the impact of micronutrients on GDM risk, particularly with the Indian ethnic phenotype, requires exploration

Objectives: To compare the micronutrient intake between GDM and non-GDM pregnancies and evaluate the association between specific dietary micronutrients and GDM risk

Methods: An observational cross-sectional study was conducted among 115 South Indian pregnant women. Dietary history was taken using 24-hour recalls on two occasions and analysed via the Indian Food Composition Table (IFCT). GDM was diagnosed using International Association of …

What’S Sleep Got To Do With It? A Mixed Methods Exploration Of The Feasibility, Acceptability, And Initial Outcomes Of Group Cbt For Insomnia In Parkinson’S Disease, Claire M. Williams

Theses and Dissertations

Parkinson’s disease is a progressive neurodegenerative disease that is commonly associated with sleep disturbances, affecting up to 80 percent of individuals with Parkinson’s. Effective and accessible treatments for sleep problems in Parkinson’s disease remain limited. Cognitive Behavioral Therapy for Insomnia (CBTi) is a well-established, non-pharmacological treatment for insomnia but has been minimally studied in Parkinson’s populations. This study evaluated the feasibility, acceptability, and preliminary outcomes of a group-based CBTi intervention adapted for individuals with Parkinson’s disease. Participants engaged in a six-week group intervention that incorporated Parkinson’s-specific adaptations. Preliminary findings indicated that the adapted group CBTi intervention was generally feasible and …

Assessment Of Major Adverse Cardiovascular Event Across Diverse Racial Groups Of Psoriasis Patients On Biologic Therapy: A Retrospective Cohort Study, Chunghwan Ro, Ana Ormaza Vera, Waleed Adawi, Clinton W. Enos

Department Dermatology Faculty Publications

Psoriasis is associated with an increased risk of major adverse cardiovascular events (MACE), and biologic therapy may reduce this risk by targeting systemic inflammation. However, limited data exist on whether long term MACE risk differs by biologic class or across racial groups. We conducted a retrospective cohort study to assess the risk of primary MACE in psoriasis patients receiving biological therapies, stratified by biological class, compared with biologic-naïve psoriasis patients. Whether MACE risk among biologic-treated patients varied by race was further examined. After 1:1 propensity score matching, 36 330 biologic-treated patients were compared with 36 330 non-biologic-treated patients. Incident MACE …

Sex Differences In Clinical Characteristics, Treatment, And Outcomes Of Cardiovascular Disease: Kenya Heart Registry Analysis, Lilian Mbau, Martha Gulati, Mzee Ngunga, Jasmit Shah, Felix Barasa, Jeilan Mohamed, Anders Barasa, Bernard Gitura, Harun Otieno, Etienne Amendezo

Internal Medicine, East Africa

Background Cardiovascular disease is the leading cause of death globally, with approximately 80% of these deaths occurring in low- and middle-income countries. Sex differences in cardiovascular disease are well described in high-income countries but limited in low- and middle-income countries.

Objectives This study sought to evaluate the sex differences in clinical presentation, cardiovascular risk profile, diagnosis, treatment, and outcomes among patients in the Kenya Heart Registry.

Methods Data were prospectively collected from 3 tertiary hospitals, including patients with heart failure, acute coronary syndrome, venous thromboembolism, and atrial fibrillation. Primary outcomes were in-hospital and 6-month mortality, as well as sex-specific differences …

Incorporating New Guidelines Into School-Based Asthma Management, Jessica Michala Jindra, Angela Duff Hogan

Department of Pediatrics Faculty Publications

Purpose of the Review

The aim of this review is to identify barriers and provide solutions to the implementation of inhaled corticosteroid-formoterol as rescue therapy within schools.

Recent findings

GINA guidelines in 2019 and NAEPP in 2020 recommended inhaled corticosteroids combined with formoterol for a rescue inhaler over the traditional short-acting beta-agonist.

Summary

The findings discussed in this article describe the barriers to the implementation of inhaled corticosteroids combined with formoterol for a rescue inhaler in school systems. Traditional asthma action plans, school nursing and parental education, and differences in dosing are some barriers identified. This paper provides solutions for …

A Comprehensive Overview Of Neurophysiological Correlates Of Cognitive Impairment In Amyotrophic Lateral Sclerosis, Seyyed Bahram Borgheai, Brie E. Achorn, Alyssa H. Zisk, Sarah M. Hosni, Karl E. G. Richter, Frank S. Menniti, Yalda Shahriari

Computer Science Faculty Publications

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that leads to the gradual loss of motor control, typically resulting in paralysis and death within 3 to 5 years of diagnosis. ALS shares neuropathological and genetic associations with fronto-temporal dementia (FTD), a neurodegenerative condition primarily impacting cognitive functions. These two conditions are increasingly viewed as manifestations of a single molecular disease process that affects distinct brain systems, impacting motor neuronal pathways in ALS and fronto-cortical functions in FTD. However, this simple dichotomy belies the complexity of these conditions. In particular, patients with primary motor ALS can also experience significant cognitive …

Attf-Gnn: An Attention-Based Multi-Omics Graph Neural Network With Modality Learning For Disease Subtyping, Sovon Chakraborty, Eleni Adam, Terry Stilwell, Harold Riethman, Desh Ranjan, Pratip Rana

Computer Science Faculty Publications

We propose AttF-GNN, an attention-based graph fusion strategy for diseases classification and subtyping. In multiomics analysis, not all types of molecular data are equally relevant for disease subtyping and considering all modalities equally may obscure discriminative signals and limit the effectiveness of predictive models by overlooking modality-specific contributions. Therefore, we design an attention-based multimodal GraphSAGE framework that can automatically emphasize the modalities providing the most relevant information for classification. At first, we have constructed three graphs using mRNA, RNA-seq and DNA methylation modalities, and train each omics with individual GraphSAGE encoders. Next, a unified intersection graph is formed using an …

Attention-Based Multi-Omics Fusion For Drug Synergy Prediction, Kusal Debnath, Pratip Rana, Preetam Ghosh

Computer Science Faculty Publications

Drug combination therapy in disease management gained popularity in the last few decades. Computational modeling of such combinations is an active area of research in the drug discovery domain. While earlier approaches solely emphasized on the structural features of participating drugs for designing synergistic models, they lack other crucial factors directly linked with drug administration - omics expressions. As differential omics expression is a downstream consequence of the administered drug combinations, utilizing such expressions while designing synergistic models promises robust and dynamic modeling. In this work, we propose SynergyLM that fuses multi-omics features with drug embeddings to build an omics-aware …

Establishment Of A Conditionally Replicating Guinea Pig Cytomegalovirus Model For Molecular Characterization Of Latency, Akshay R. Molakalapalli, Saketh Majeti, Michael A. Mcvoy, Jian Ben Wang

UROP Posters

Human cytomegalovirus (HCMV) is a member of the Herpesviridae that establishes life-long latent infections that pose risks of life-threatening disease upon reactivation in immunocompromised individuals. Understanding the molecular mechanisms that govern the latent state is critical for developing effective treatments. However, molecular characterization has been impeded by the scarcity of latently infected cells in vivo and the inability of current in vitro models to support the expansion of clonal latent cell lines. To address these limitations, we developed a novel cell culture model utilizing a conditionally replicating guinea pig cytomegalovirus, a relative of HCMV that mimics HCMV pathology and provides …

Microsolvation Effects Of 1,1-Dimethyl-Biguanide (Metformin), Jasmine L. Sanders

Honors Theses

The microsolvation of a 1,1-dimethyl-biguanide hydrochloride molecule in the presence of water molecules illustrates the initial interactions between the common drug metformin and water. This explicit water-solvation approach employs coupled-cluster theory with an explicit-correlation F12 correction and the cc-pVTZ-F12 basis set to determine the optimalgeometry of the molecule and to observe intermolecular interaction energies. 1,1-dimethyl-biguanide hydrochloride (an antidiabetic agent, metformin) is constantly in contact with water molecules in the human body, where it reduces intestinal glucose absorption, lowers hepatic glucose sensitivity, and improves overall insulin sensitivity to lower blood-glucose concentration. The B3LYP method with an aug-cc-pVTZ basis set is used …

Genomic Determinants Of Appetite Regulation And Their Role In Obesity Risk, Timothy J. Renier

Dartmouth College Ph.D Dissertations

Over 40% of US adults and 20% of children live with obesity. It is related to increased risks of diseases including type II diabetes and cancer, is a source of harmful stigma, and impairs child development. Appetitive traits describing patterns of food approach and avoidance behaviors may serve as windows into the underlying pathophysiology of obesity. As both obesity and appetitive traits are heritable, common genetic drivers of obesity may lead to phenotypic obesity through appetitive traits as a disease mechanism. Additionally, GLP-1 receptor agonists (GLP-1RAs) have been shown to exert their profound clinical effects in part by modulating appetite. …

A Scoping Review To Conceptualize Social Privilege For Studying Patients' Health Outcomes And Health Disparities, Elizabeth A. Brown, Priyanka Patel, Esther May B. Sarino, Vladimir Markovic, Carles Muntaner

Health Behavior, Policy & Management Faculty Publications

Background

The continued reliance on single-category self-reported demographic data (e.g., race/ethnicity) reflects conceptual limitations that hinder the study and understanding of health outcomes research. There is a pressing need for more precise measures of social privilege that conceptualize privilege and oppression while enabling the examination of their effects on health outcomes in the United States (US) healthcare system.

Objective

The purpose of this scoping review was to review the literature, determine how researchers have measured aspects of privilege and oppression, and develop a conceptual framework to study patients' social privilege in the US healthcare system and public health research.

Methods …

Variability In Parainfluenza Virus Derived From Persistently Infected Lung Epithelial Cells, Cassidy R. Conte

Honors Undergraduate Theses

An acute infection (AI) with RNA virus can progress to a persistent infection (PI) where infected cells continue to grow and replicate while producing progeny virions. PIs with respiratory viruses are clinically important, as they can lead to prolonged shedding of viruses and generation of mutant viruses that are altered in pathogenesis and/or immune responses. Parainfluenza type 5 (PIV5) is a prototypic RNA virus shown to cause PIs in cell culture. Plaques in tissue culture from an acute infection with parental PIV5 were homogeneous in size and shape. By contrast, plaques from PIV5 persistently infected cells were heterogeneous, having a …

Cologuard, Call To Action! A Structured Outreach Intervention For Patients With Unreturned Cologuard Kits, Crystal Bharat, Sophia Zia, Harsh Bhatt, Abd Almasih Barbar Askar, Kulwinder Bhatnura, Dhruv Patel, Dennis Besong

South Atlantic Division GME Research Days 2026

No abstract provided.

Red Flags: Intraoperative Transfusion As A Predictor Of Anastomotic Failure, Alejandro De Leon Castro, Aj Schwartz, A Todd-Tharaday, A Collier, Ch Meyer, C Dente, Rn Smith, Jd Sciaretta, J Nguyen

South Atlantic Division GME Research Days 2026

No abstract provided.

Comparative Assessment Of Arterial Line And Pulse Contour Derived Hemodynamics Monitoring In A Post-Cardiac Surgery Icu Patient: Pilot Observation, Chiraag Ashokkumar, Justin Gisel

South Atlantic Division GME Research Days 2026

No abstract provided.

Biphasic Calcium Disturbance In Rhabdomyolysis: A Case Report Of Recovery Phase Severe Hypercalcemia, Maham Shahid, Jean C. Ramos-Cardona, Maria Toustsoglou, Gunjan Y. Gandhi

South Atlantic Division GME Research Days 2026

No abstract provided.

Healing Times Of Mohs Defects Using Cellular, Acellular, And Matrix-Like Products Compared With Secondary Intention In A Single Patient, Benjamin R. Cooper, Anthony Concilla, Kathleen Ward, Taha Rasul, Arianne E. Chavez

South Atlantic Division GME Research Days 2026

No abstract provided.

Use Of Ultrasound In The Pre-Hospital Setting To Differentiate Acute Dyspnea, Kenith D'Souza, Michael Cabebe, Taryn Hoffman, Martin Wegman, Justin Deaton, Christopher Carney

South Atlantic Division GME Research Days 2026

No abstract provided.

Myxedema Coma With Cardiogenic Shock: Diagnostic Challenges And Risks Of Amiodarone In Acute Thyroid Failure, Munachiso Egbo, Jean Ramos-Cardona, Gunjan Mundhra, Veniamin Melnychuk, Suzanne Martinez

South Atlantic Division GME Research Days 2026

No abstract provided.

Beneath The Pigment: An Unusual Cystic Complication Of Red Ink, Tamara Fakhoury, Erika Pulver, Karissa Lehew, Angelia Stepien

South Atlantic Division GME Research Days 2026

No abstract provided.

Catheter Directed Therapy In Acute Pulmonary Embolism: Patient Characteristics And Variability, Kalyan Mantha, W Angelo Kantrales, Brooke Mcmurtie, Caroline Mills, Martin Wegman

South Atlantic Division GME Research Days 2026

No abstract provided.

A Diagnostic Dilemma: Rcvs Or Pacns In A Young Adult, Jyoti Moorjani, Reina Kwon, Karissa Lehew, Rohan Gupta, Kainat Khan, Harry Marty-Vigo

South Atlantic Division GME Research Days 2026

No abstract provided.

Comprehensive Profiling And Clinical Utility Of Csf-Derived Cell-Free Dna/Rna For Evaluation Of Solid And Hematologic Malignancies Affecting The Central Nervous System, Renee Morecroft, Ryan Gimple, Maher Abitar, Omar Butt

South Atlantic Division GME Research Days 2026

No abstract provided.

The History We Didn't Hear: An M&M On Communication And Misinformation, Ansh Patel, Anjan Parghi

South Atlantic Division GME Research Days 2026

No abstract provided.

Percutaneous Vegetectomy As An Emerging Alternative For Tricuspid Valve Endocarditis, Alexander Patel, Elias Wakim, William Zvagelsky, Ebad Ur Rahman, Youssef Al-Saghir, Ahmed Zaky

South Atlantic Division GME Research Days 2026

No abstract provided.

High-Grade Undifferentiated Sarcoma With Osteoclast-Like Giant Cells Mimicking A Pyogenic Granuloma, Shiv Patel, Tamara Fakhoury, Taha Rasul, Benjamin Cooper, Leila Parsa, Madeline Coleman, Alexandra Mathis, Karthik Krishnamurthy, Michelle Foley

South Atlantic Division GME Research Days 2026

No abstract provided.

How Does Pulse Field Ablation Compare To Radiofrequency Ablation In The Creation Of Cavotriscupid Isthmus Line In Patients With Atrial Arrythmias?, Sharul Saxena, Veniamin Melnychuk, Sadhana Jonna, Gunjan Mundhra, Firas El Sabbagh

South Atlantic Division GME Research Days 2026

No abstract provided.

Robotic Assisted Duodenojejunostomy In The Treatment Of Adult Annular Pancreas, Anthony Sciuva, Denise Vera Nemeth, Riley Burgon, Noaman Ali

South Atlantic Division GME Research Days 2026

No abstract provided.