Digital Commons Network^™

The Future Of Ai Regulation In Drug Development: A Comparative Analysis, Gabriela Lenarczyk, Timo Minssen, W. Nicholson Price Ii, Arti Rai

Articles

As artificial intelligence (AI) transforms drug development, regulatory frameworks are evolving to oversee its implementation, particularly at the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA). This paper makes three contributions to understanding emerging regulatory approaches. First, we offer a comparative analysis of how these agencies have responded to AI-driven advances, incorporating new US executive orders and the European Union (EU)’s AI Act. Second, we propose a novel analytical framework to understand regulatory divergence: the FDA’s flexible, dialog-driven model contrasts with the EMA’s structured, risk-tiered approach, reflecting broader institutional and political-economic differences. While the former encourages …

Development Of An Ecg-Based Deep Learning Model For Pediatric Congenital Heart Disease (Chd) Diagnosis, Annbar Mekouar

Selected Full-Text Master Theses 2021-

Congenital heart disease (CHD) stands as the leading congenital anomaly which affects pediatric populations throughout the world. The effectiveness of treatment depends on both early diagnosis and accurate identification but echocardiography requires manual interpretation which proves time-consuming and inconsistent especially when examining pediatric patients with their distinct cardiac systems. The research aims to create a deep learning-based diagnostic framework which uses ECG data to identify coronary artery disease subtypes in pediatric patients. The model uses high-quality datasets from Dr. Ignacio Lugones to extract R-R intervals and QRS durations through convolutional neural networks (CNNs). The system addresses pediatric-specific challenges while enhancing …

A Machine Learning Based Framework For Predicting Drug Cardiotoxicity Using A Combination Of Ecg Biomarkers And Drug Dosage Data, Jamie Wong

Selected Full-Text Master Theses 2021-

Drug-induced cardiotoxicity presents a significant challenge in clinical practice and drug clinical development, particularly with medications that modulate calcium, potassium, and sodium channels that influence cardiac electrophysiology. Clinical practice often relies on QTc prolongation alone as a predictor, which lacks specificity and may lead to excluding other safe therapeutic options. To address this limitation, this study integrates electrocardiogram (ECG) biomarkers with normalized drug dosage data to improve the accuracy of cardiotoxicity risk prediction using machine learning techniques. ECG features, including QT, QRS, RR, and PR intervals, were analyzed alongside normalized dosage data to account for dose-dependent cardiac effects. A physiologically …

Leveraging Data Science For Resilience: Improving Trauma-Informed Care Practice For Adverse Childhood Experience With Ai & Data Science Application, Mohmmad Arif Shaik

Master's Theses

Adverse Childhood Experiences (ACEs) have long-lasting effects on physical health, mental well-being, education, and socioeconomic outcomes. Resilient Georgia (RG), a statewide initiative, seeks to address ACEs through trauma-informed care and data-driven strategies. However, challenges in data collection, analysis, and tracking set back the effectiveness of these efforts. This study explores the role of data science and interactive visualization tools in improving outcomes for individuals and communities affected by ACEs. A key focus of this research is the development of a data science management application designed to enhance data collection and improve real-time decision-making. The application features interactive dashboards that allow …

Applying Transfer Learning For Street-Scale Nuisance Flood Forecasting In Coastal-Urban Cities, Binata Roy, Jonathan L. Goodall, Diana Mcspadden, Chetan Kumar, Steven Goldenberg, Yidi Wang, Malachi Schram

VMASC Publications

An important challenge with Machine Learning (ML) is its transferability; i.e., whether a ML model trained on one set of data can be applied to a second set of data without requiring full re-training of the model. Transfer Learning (TL) addresses this challenge by transferring knowledge learned in the source domain (the data it was trained on) to the target domain (a second set of data that is statistically different but related, which the model was not trained on). This study investigates the use of TL for street-scale nuisance flood forecasting by exploring whether a ML model trained for one …

Faithful Narratives From Complex Conceptual Models: Should Modelers Or Large Language Models Simplify Causal Maps, Tyler J. Gandee, Philippe J. Giabbanelli

VMASC Publications

(1) Background: Comprehensive conceptual models can result in complex artifacts, consisting of many concepts that interact through multiple mechanisms. This complexity can be acceptable and even expected when generating rich models, for instance to support ensuing analyses that find central concepts or decompose models into parts that can be managed by different actors. However, complexity can become a barrier when the conceptual model is used directly by individuals. A ‘transparent’ model can support learning among stakeholders (e.g., in group model building) and it can motivate the adoption of specific interventions (i.e., using a model as evidence base). Although advances in …

Predictive Maintenance In Naval Vessel Propulsion Systems For Enhanced Marine Operations Using A Bigmm-Hmm Framework With Divergence-Based Clustering, Farshid Javadnejad, Hyoshin John Park, Samuel Kovacic, Andres Sousa-Poza

Engineering Management & Systems Engineering Faculty Publications

This study introduces a BiGMM-HMM Integration Framework designed to improve predictive maintenance strategies for naval vessel propulsion systems, addressing the need for efficient and reliable operation in marine engineering applications. The framework effectively manages multimodal sensor data by leveraging a unique combination of Gaussian Mixture Models (GMMs) and Hidden Markov Models (HMMs) in a bidirectional architecture. It analyses the dynamic interactions between sensors and subsystems. Two preprocessing methods are evaluated: Method 1 focuses on subsystem interactions, employing divergence-based root cause analysis to identify key sensor variables by clustering of sensors and subsystems. In contrast, Method 2 processes the entire dataset …

Optimizing Port Logistics Through Generative Ai: Revolutionizing Efficiency And Resilience In The Maritime Industry, Minodora Badea, Olga Bucovetchi, Adrian V. Gheorghe, Gabriel Raicu

Engineering Management & Systems Engineering Faculty Publications

The maritime industry faces growing challenges in optimizing port logistics due to increasing trade volumes, environmental regulations, and supply chain disruptions. This comprehensive literature review examines the transformative role of artificial intelligence (AI), with particular focus on generative AI, in enhancing efficiency and resilience in port operations. Through systematic analysis of 23 peer-reviewed studies published between 2021-2025, this review synthesizes advancements in real-time data integration, machine learning, digital twins, IoT, and autonomous systems that collectively improve operational decision-making, risk management, and environmental sustainability. Key findings reveal that machine learning applications achieve 90% effectiveness ratings in operational optimization, while predictive analytics …

Comprehensive Benchmarking Of Several Machine Learning And Bayesian Models For Early-Stage Diabetes Risk Prediction: A Large-Scale Comparative Study, Md. Iqbal Hossain, Najila Alam Porno

Mathematics & Statistics Faculty Publications

Diabetes remains a critical global health challenge, with early detection is crucial for effective management. This study presents a comprehensive benchmarking analysis of 14 diverse machine learning and Bayesian models for early-stage diabetes risk prediction using clinical data [2] from Sylhet, Bangladesh. This research evaluated traditional methods (Logistic Regression, Decision Trees), ensemble techniques (Random Forest, XGBoost, LightGBM), Bayesian approaches (BART, Bayesian Logistic Regression), and advanced neural architectures (Deep Belief Networks) using both 70-30 train-test splits and 10-fold cross-validation. The results demonstrate that ensemble methods consistently outperformed other approaches, with Random Forest(RF) achieving the highest cross-validated AUC (0.9951) and accuracy (0.9699). …

A Systematic Review And Taxonomy For Privacy Breach Classification: Trends, Gaps, And Future Directions, Clint Fuchs, John Hastings

Research & Publications

In response to the rising frequency and complexity of data breaches and evolving global privacy regulations, this study presents a comprehensive examination of academic literature on the classification of privacy breaches and violations between 2010-2024. Through a systematic literature review, a corpus of screened studies was assembled and analyzed to identify primary research themes, emerging trends, and gaps in the field. A novel taxonomy is introduced to guide efforts by categorizing research efforts into seven domains: breach classification, report classification, breach detection, threat detection, breach prediction, risk analysis, and threat classification. An analysis reveals that breach classification and detection dominate …

Temporal Machine Learning For Predicting Accidents And Violations In The Mining Industry, Nathan T. Kelley

Theses and Dissertations--Mining Engineering

This thesis examines the predictive capability of a temporal machine learning model for forecasting future accidents and violations at individual mines, based on historical data. Mine accidents were categorized by accident classification and violations were categorized by the Part Section. The primary datasets utilized were the mine safety and health administration’s (MSHA’s) Accident Injuries and Violations datasets. The available datasets were cleaned and organized by mine type and commodity, then divided into separate subsets for training, validating, and testing. Different models, cutoff metrics, learning rates, number of hidden layers, data processing methods, data processing divisions, number of points observed …

Enhancing Public Health Surveillance: Development And Validation Of Machine Learning Models For Suspected Opioid Overdose Detection In Emergency Medical Services Data, Peter J. Rock

Theses and Dissertations--Clinical and Translational Science

The ongoing opioid overdose crisis in the United States requires timely and accurate surveillance systems to inform public health responses. Traditional public health surveillance methods rely on hospital discharge data and death certificates, which suffer from significant reporting delays and miss cases where patients refuse hospital transportation. Emergency Medical Services (EMS) data presents a promising alternative with advantages in timeliness and case ascertainment but lacks validated definitions for suspected opioid overdose (SOO).

This dissertation addresses this critical gap through the development, validation, and fairness assessment of machine learning models with natural language processing (ML-NLP) for identifying SOOs in EMS data. …

Analysing Nontraditional Students' Chatgpt Interaction, Engagement, Self-Efficacy And Performance: A Mixed-Methods Approach, Mohan Yang, Shiyan Jiang, Belle Li, Kristin Herman, Tian Luo, Shanan Chappell Moots, Nolan Lovett

STEMPS Faculty Publications

Generative artificial intelligence brings opportunities and unique challenges to nontraditional higher education students, stemming, in part, from the experience of the digital divide. Providing access and practice is critical to bridge this divide and equip students with needed digital competencies. This mixed-methods study investigated how nontraditional higher education students interact with ChatGPT in multiple courses and examined relationships between ChatGPT interactions, engagement, self-efficacy and performance. Data were collected from 73 undergraduate and graduate students through chat logs, course reflections and artefacts, surveys and interviews. ChatGPT interactions were analysed using four metrics: prompt number, depth of knowledge (DoK), prompt relevance and …

Exploratory Data Analysis (Eda) And Predictive Machine Learning (Ml) For Buildings’ Energy Fault Detection, Akshith Nukala

Theses and Dissertations

Building energy load fault detection is a critical challenge in energy usage analysis. It helps uncover energy wastage, machinery/appliance degradation or inefficiency, and failures or faults in buildings’ HVAC (heating, ventilation, and air conditioning) systems. Early identification of machinery failure and energy wastages due to operational maintenance negligence in large sites such as campus buildings is indispensable for achieving energy efficiency. This is crucial for saving patrol and minimizing the response time to restore the building appliances or systems to their optimal state.

Advancements in state-of-the-art AI/ML data-driven algorithms and techniques enabled us to build accurate, efficient and scalable fault …

Blockchain-Based Trust Model For Inter-Domain Routing, Qiong Yang, Li Ma, Sami Ullah, Shanshan Tu, Hisham Alasmary, Muhammad Waqas

Research outputs 2022 to 2026

Border Gateway Protocol (BGP), as the standard inter-domain routing protocol, is a distance-vector dynamic routing protocol used for exchanging routing information between distributed Autonomous Systems (AS). BGP nodes, communicating in a distributed dynamic environment, face several security challenges, with trust being one of the most important issues in inter-domain routing. Existing research, which performs trust evaluation when exchanging routing information to suppress malicious routing behavior, cannot meet the scalability requirements of BGP nodes. In this paper, we propose a blockchain-based trust model for inter-domain routing. Our model achieves scalability by allowing the master node of an AS alliance to transmit …

Towards Robust Multimodal Land Use Classification: A Convolutional Embedded Transformer, Muhammad Zia Ur Rehman, Syed Mohammed Shamsul Islam, Anwaar Ulhaq, David Blake, Naeem Janjua

Research outputs 2022 to 2026

Multisource remote sensing data has gained significant attention in land use classification. However, effectively extracting both local and global features from various modalities and fusing them to leverage their complementary information remains a substantial challenge. In this paper, we address this by exploring the use of transformers for simultaneous local and global feature extraction while enabling cross-modality learning to improve the integration of complementary information from HSI and LiDAR data modalities. We propose a spatial feature enhancer module (SFEM) that efficiently captures features across spectral bands while preserving spatial integrity for downstream learning tasks. Building on this, we introduce a …

Novel Digital Twin Deployment Approaches: Local And Distributed Digital Twin, Shahid Rauf, Fazal Muhammad, Akhtar Badshah, Hisham Alasmary, Muhammad Waqas, Sheng Chen

Research outputs 2022 to 2026

The Digital Twin (DT) technology is considered as a backbone in the Industrial 4.0 revolution as it is playing a vital role in the digitization of various industries. A DT is a virtual representation of a physical entity, thus having the ability to simulate real data generated at physical space to optimize, estimate, control, monitor and forecast states/configurations. Despite enormous benefits, DT technology has several implementation challenges. Although deploying DT on edge or cloud platforms yields a plethora of services, its implementation in both spaces faces certain limitations. These limitations include latency, data communication overload, transmission energy consumption, privacy concerns, …

Automated Methods For Estimating Blood Alcohol Concentration Level From Facial Cues, Ensiyeh Keshtkaran

Theses: Doctorates and Masters

This thesis investigates different approaches for detecting alcohol intoxication in drivers by analysing facial video data. Tackling this issue necessitates the creation of a novel dataset to overcome the limitations of existing datasets. The dataset constructed in this study is the first to include RGB video recordings of individual faces at varying levels of alcohol intoxication during simulated driving, featuring 60 participants with BAC levels ranging from 0 to 0.165 g/100ml. The constructed dataset not only supports this thesis, but also offers the broader scientific community a valuable resource for further study and development.

Building on this, this thesis presents …

Machine Learning For Computer-Aided Diagnostics From Complex Medical Images, Afsah Saleem

Theses: Doctorates and Masters

Machine learning has significantly transformed medical image analysis in the current age of artificial intelligence offering vast potential in improving disease diagnosis and management. Cardiovascular diseases (CVDs) are among the leading cause of global mortality, emphasizing the need for early detection for effective intervention and prevention. Abdominal Aortic Calcification (AAC) is an early indicator and contributor to Atherosclerotic Cardiovascular Diseases (ASCVDs) and is commonly assessed through imaging modalities such as computed tomography (CT), X-rays, and Dual-energy X-ray Absorptiometry (DXA). Among these, lateral spine DXA scans, commonly used for osteoporosis screening, offer a cost-effective and low-radiation opportunity for opportunistic CVD risk …

Embodied Ai For Challenging Rearrangement Tasks In The Context Of Service And Assistive Robots, Mariia Khan

Theses: Doctorates and Masters

Embodied AI explores intelligent agents that learn through interaction with their environment, aiming to replicate human-like learning processes. Achieving this requires agents capable of understanding a scene via various sensors, reasoning about their actions, and reacting accordingly. These abilities are necessary for service domestic robots to assist humans in their day-to-day activities. Embodied AI tasks can include but are not limited to: visual exploration, visual navigation, instruction following and embodied question answering, which typically consider static (unchanging) environments, where objects do not move over time. This thesis addresses one of the most challenging Embodied AI tasks – visual room rearrangement, …

Anomaly Detection Of Seasonal Vessel Activity, Travis Rybicki

Theses: Doctorates and Masters

Monitoring maritime traffic is essential for ensuring the safety of vessels, safeguarding transported goods or persons, and preventing illicit or hazardous activity at sea. Increasingly, researchers have explored data-driven approaches to model expected vessel behaviour and detect deviations or anomalies. These anomalies—such as course deviations, unauthorised area entries, or unexpected operational patterns—can indicate emergencies, regulatory breaches, or unlawful intent. Data broadcast by vessels provides a valuable resource for such analyses; however, the inherent complexity and context-dependency of maritime behaviour present persistent modelling challenges. One critical yet underutilised factor in this context is seasonality. For certain vessel types, for example, fishing …

Ethics Vs.. Regulation: Converging Frameworks For Trustworthy Human-Centered Ai In Biomedical Research, Tayo Obafemi-Ajayi, Tiffani J. Bright, Emily F. Wong, Donald Wunsch, Joan Peckham, Jason H. Moore

Electrical and Computer Engineering Faculty Research & Creative Works

The accelerating impact of AI in biomedical research is driving significant advances in precision medicine. As these systems increasingly shape health outcomes, the imperative to develop trustworthy, reliable, and ethically grounded AI becomes more pressing, particularly in addressing concerns related to data integrity, patient safety, and equitable outcomes. While the potential of AI to transform biomedical research is clear, its responsible integration depends on more than technological capability. Ensuring that these systems are aligned with societal values requires a dual commitment: the operationalization of ethical principles throughout the AI life cycle and the establishment of robust regulatory mechanisms. Ethics provides …

Understanding The Influence Of Image Enhancement On Underwater Object Detection: A Quantitative And Qualitative Study, Ashraf Saleem, Ali Awad, Sidike Paheding, Evan Lucas, Timothy C. Havens, Peter C. Esselman

Michigan Tech Publications

Underwater image enhancement is often perceived as a disadvantageous process to object detection. We propose a novel analysis of the interactions between enhancement and detection, elaborating on the potential of enhancement to improve detection. In particular, we evaluate object detection performance for each individual image rather than across the entire set to allow a direct performance comparison of each image before and after enhancement. This approach enables the generation of unique queries to identify the outperforming and underperforming enhanced images compared to the original images. To accomplish this, we first produce enhanced image sets of the original images using recent …

Sift Feature-Based Relative Altitude Estimation Enhanced With Siamese Network, Shirin Nasr-Esfahani, S. Jagannathan

Electrical and Computer Engineering Faculty Research & Creative Works

In GPS-denied environments or when GPS signals are unreliable or unavailable, alternative methods of accurate localization with coordinate generation become critical. To address localization, the scale-invariant feature transform (SIFT) algorithm, along with its numerous adaptations, is extensively utilized in computer vision and remote sensing for matching image features to identify objects and perform localization. This article presents a novel approach for estimating the relative altitude of unmanned aerial vehicles (UAVs) using SIFT features' scale (size), omitting the need for additional data like camera intrinsic parameters, as well as extensive image datasets are also required for training. Furthermore, the approach enhances …

Foundation Models Boost Low-Level Perceptual Similarity Metrics, Abhijay Ghildyal, Nabajeet Barman, Saman Zadtootaghaj

Computer Science Faculty Publications and Presentations

For full-reference image quality assessment (FR-IQA) using deep-learning approaches, the perceptual similarity score between a distorted image and a reference image is typically computed as a distance measure between features extracted from a pretrained CNN or more recently, a Transformer network. Often, these intermediate features require further fine-tuning or processing with additional neural network layers to align the final similarity scores with human judgments. So far, most IQA models based on foundation models have primarily relied on the final layer or the embedding for the quality score estimation. In contrast, this work explores the potential of utilizing the intermediate features …

“Lost-In-The-Later”: Framework For Quantifying Contextual Grounding In Large Language Models, Yufei Tao, Adam Hiatt, Rahul Seetharaman, Ameeta Agrawal

Computer Science Faculty Publications and Presentations

Large language models (LLMs) are capable of leveraging both contextual and parametric knowledge but how they prioritize and integrate these sources remains underexplored. We introduce CoPE, a novel framework for systematically quantifying contextual grounding in LLMs. CoPE distinguishes between contextual knowledge (CK) and parametric knowledge (PK), enabling fine-grained attribution across languages and tasks. Using our newly created MultiWikiAtomic dataset in English, Spanish, and Danish, we analyze how LLMs integrate context, prioritize information, and incorporate PK in open-ended question answering. We find that across models and languages, only around 50 to 76 percent of outputs are grounded in the given context, …

Drta: Dynamic Reward Scaling For Reinforcement Learning In Time Series Anomaly Detection, Bahareh Golchin, Banafsheh Rekabdar, Kunpeng Liu

Computer Science Faculty Publications and Presentations

Anomaly detection in time series data is important for applications in finance, healthcare, sensor networks, and industrial monitoring. Traditional methods usually struggle with limited labeled data, high false-positive rates, and difficulty generalizing to novel anomaly types. To overcome these challenges, we propose a reinforcement learning-based framework that integrates dynamic reward shaping, Variational Autoencoder (VAE), and active learning, called DRTA. Our method uses an adaptive reward mechanism that balances exploration and exploitation by dynamically scaling the effect of VAE-based reconstruction error and classification rewards. This approach enables the agent to detect anomalies effectively in low-label systems while maintaining high precision and …

Scitopic: Enhancing Topic Discovery In Scientific Literature Through Advanced Llm, Pengjiang Li, Zaitian Wang, Xinhao Zhang, Ran Zhang, Lu Jiang, Pengfei Wang, Yuanchun Zhou

Computer Science Faculty Publications and Presentations

Topic discovery in scientific literature provides valuable insights for researchers to identify emerging trends and explore new avenues for investigation, facilitating easier scientific information retrieval. Many machine learning methods, particularly deep embedding techniques, have been applied to discover research topics. However, most existing topic discovery methods rely on word embedding to capture the semantics and lack a comprehensive understanding of scientific publications, struggling with complex, high-dimensional text relationships. Inspired by the exceptional comprehension of textual information by large language models (LLMs), we propose an advanced topic discovery method enhanced by LLMs to improve scientific topic identification, namely SciTopic. Specifically, we …

Genai’S Impact On Global It Management: A Multi-Expert Perspective And Research Agenda, Yogesh K. Dwivedi, Laurie Hughes, Mohammad S. Al-Ahmadi, Vincent Dutot, Syed Q. Ahmed, Shahriar Akter, Rahul De’, Keyao Li, Nitish Singh, Paul Walton

Research outputs 2022 to 2026

Generative AI (GenAI) is disrupting global IT management and challenging established practice. The increasing use of GenAI technology is redefining localization, transforming existing workforce roles, outsourcing strategy, and team dynamics. Simultaneously, GenAI’s security complexities have prompted the rethinking of existing risk frameworks to meet a new set of challenges from GenAI enhanced cyber threats. This article explores these complex and converging factors, providing a roadmap to address GenAI’s significant impact on global IT management. We advocate the responsible adoption of GenAI and importance of building resilient, value-driven, globally consistent IT ecosystems able to adapt to the significant challenges and opportunities …

Toward Privacy-Preserving Data Sharing - An Australian Healthcare Perspective, Kimley Foster, Nectarios Costadopoulos, Arash Mahboubi, Sabih Ur Rehman, Md Zahidul Islam

Research outputs 2022 to 2026

The rise of big data has brought increased urgency to the importance of privacy-preserving data sharing in healthcare. In Australia, health records exist in various databases; however data sharing is limited. While many consumers and healthcare professionals recognise the advantages of sharing data for research and health care services, misgivings about privacy and security persist. This study examined current perspectives on data sharing, investigating the trust level in privacy preserving data sharing tools and techniques among healthcare professionals and organisations, and their openness to adopting technology for secure data sharing. We incorporated participants from various healthcare professions across Australia. We …