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Applying Machine Learning Methods To Generate Understandings Of Differential Item Functioning In A Flu Knowledge Assessment, William L. Romine, Tanvi Banerjee, Derrick Cox Jan 2025

Applying Machine Learning Methods To Generate Understandings Of Differential Item Functioning In A Flu Knowledge Assessment, William L. Romine, Tanvi Banerjee, Derrick Cox

Computer Science and Engineering Faculty Publications

Current influenza trends, including the severity of the 2025 flu season and the prevalence of H5 bird flu in livestock, necessitate efforts to better understand how to educate students about its transmission. Although validated assessments of influenza knowledge exist, these have not been evaluated for affective and demographic biases. We explore differential item functioning (DIF) effects in four items focused on specific aspects of flu transmission derived from a validated influenza knowledge assessment. In doing so, we introduce and utilize a machine learning framework for exploration of DIF which offers greater flexibility than traditional statistical approaches in terms of studying …


Ontology-Based Data Organization For The Enslaved.Org Project, Cogan Shimizu, Pascal Hitzler Jan 2025

Ontology-Based Data Organization For The Enslaved.Org Project, Cogan Shimizu, Pascal Hitzler

Computer Science and Engineering Faculty Publications

The men, women, and children forced into slavery in the Atlantic world came from diverse African societies with long histories of political, economic, and cultural development. They were taken from the trading centers of the Hausa city-states, the farming and artisanal communities of Senegambia, the Kongo and Mbundu polities of West Central Africa, and many other regions. They carried with them agricultural expertise, metallurgical skills, medical knowledge, religious traditions, and oral histories that helped sustain communities in the face of displacement and enslavement.Enslavement did not erase this intellectual and cultural inheritance, nor did it render its victims passive numbers in …


Ontology Population Using Llms, Sanaz Saki Norouzi, Adrita Barua, Antrea Christou, Nikita Gautam, Andrew Eells, Pascal Hitzler, Cogan Shimizu Jan 2025

Ontology Population Using Llms, Sanaz Saki Norouzi, Adrita Barua, Antrea Christou, Nikita Gautam, Andrew Eells, Pascal Hitzler, Cogan Shimizu

Computer Science and Engineering Faculty Publications

No abstract provided.


Bytes, Banter, And The Bible: An Interdisciplinary Account Of Objective Meaning, Cameron Bonin Jan 2025

Bytes, Banter, And The Bible: An Interdisciplinary Account Of Objective Meaning, Cameron Bonin

Senior Honors Theses

The claim that the Bible has objective meaning is contested in a postmodern world. This claim can be more persuasively defended when it is addressed by insights from multiple disciplines. In particular, the field of computer science is apt to illuminate the concept of meaning through its reflection on the nature of languages and its concern with the accurate transmission of information. By synthesizing insights from the field of computer science, such as that of Claude Shannon, with Nicholas Wolterstorff’s use of speech-act theory, the concept of meaning can be understood more clearly. Consequently, this synthesis assists in answering questions …


Why Ai Monitoring Faces Resistance And What Healthcare Organizations Can Do About It: An Emotion-Based Perspective, Karl Werder, Lan Cao, Eun Hee Park, Balasubramaniam Ramesh Jan 2025

Why Ai Monitoring Faces Resistance And What Healthcare Organizations Can Do About It: An Emotion-Based Perspective, Karl Werder, Lan Cao, Eun Hee Park, Balasubramaniam Ramesh

Information Technology & Decision Sciences Faculty Publications

Continuous monitoring of patients' health facilitated by artificial intelligence (AI) has enhanced the quality of health care, that is, the ability to access effective care. However, AI monitoring often encounters resistance to adoption by decision makers. Healthcare organizations frequently assume that the resistance stems from patients' rational evaluation of the technology's costs and benefits. Recent research challenges this assumption and suggests that the resistance to AI monitoring is influenced by the emotional experiences of patients and their surrogate decision makers. We develop a framework from an emotional perspective, provide important implications for healthcare organizations, and offer recommendations to help reduce …


Ripples: An Automated Embedding Generation Algorithm For The Forward-Forward Algorithm, Spencer Connolly Jan 2025

Ripples: An Automated Embedding Generation Algorithm For The Forward-Forward Algorithm, Spencer Connolly

All Graduate Theses, Dissertations, and Other Capstone Projects

The Forward-Forward algorithm (FF) is yet another novel invention by Geoffrey Hinton, the creator of the famous backpropagation algorithm (BP). Since its proposal, many papers have been published exploring its potential, and good progress has been made in increasing its viability. Though FF continually falls short of BP, its purpose is not to replace BP and preliminary research shows that there is plenty of room for growth. In this paper, we present a literature review for FF algorithms applied to Convolution Neural Networks (CNN) for image classification tasks and set the stage for applying FF to more complex datasets. The …


Examining The Disclosure Of Sensitive Information Through Mobile Applications: A Privacy Calculus And Warning Experiment On Location-Based Services, Dwayne A. Ford Jan 2025

Examining The Disclosure Of Sensitive Information Through Mobile Applications: A Privacy Calculus And Warning Experiment On Location-Based Services, Dwayne A. Ford

CCAC Theses and Dissertations

Smartphones and mobile applications have become all but ubiquitous in society. These applications provide a plethora of functions both in standalone and network configurations. Many of these popular applications utilize Location-Based Services (LBS) to deliver value to the user. Whether for navigation, transportation or social interactions, sharing information is essential when using these applications. While LBS applications provide various benefits, the sharing of location data also creates significant privacy risks. In many cases, users are unaware of the real risks and continue to share their location data in exchange for the benefits the application provides.

The problem identified in this …


A Hybrid Deep Learning Model For Iot Network Anomaly Detection, Yonas Getachew Mulissa Jan 2025

A Hybrid Deep Learning Model For Iot Network Anomaly Detection, Yonas Getachew Mulissa

CCAC Theses and Dissertations

The rapid expansion of Internet of Things (IoT) networks has heightened the need for intelligent, automated Anomaly Detection (AD) systems to identify sophisticated and evolving cyber threats. This study designed, implemented, and evaluated a broad range of deep learning models—including Convolutional Neural Networks (CNN), Recurrent Neural Networks (RNNs) (Long Short-Term Memory (LSTM), Gated Recurrent Unit (GRU), Bidirectional Gated Recurrent Unit (BiGRU), Bidirectional Long Short-Term Memory (BiLSTM)), Transformer-based architectures, Autoencoders, and hybrid combinations—to address the challenge of multiclass anomaly classification in IoT traffic. Using two benchmark datasets, IoT-DS-2 and CIC-IoT-2023, we conducted extensive experiments to assess classification performance, training efficiency, and …


Development Of A Phishing Risk Exposure Taxonomy On Mobile Devices In The Healthcare Industry, Christopher P. Collins Jan 2025

Development Of A Phishing Risk Exposure Taxonomy On Mobile Devices In The Healthcare Industry, Christopher P. Collins

CCAC Theses and Dissertations

Phishing emails accessed on mobile devices present substantial risks to healthcare organizations when employees often operate under high cognitive load and with limited cybersecurity training. Despite widespread security awareness initiatives, healthcare workers continue to engage with phishing content on mobile platforms, posing threats to organizational data. Given the high value of healthcare data and the increasing sophistication of phishing schemes targeting healthcare professionals, there is a pressing need to enhance their ability to recognize phishing indicators on mobile devices.

This study developed and validated a Healthcare Workers Phishing Risk Exposure (HWPRE) taxonomy, designed to classify healthcare workers based on their …


An Evaluation Of Data Protection And Privacy Issues Introduced By Byod In Financial Institutions, Andy Miguel Santana Jan 2025

An Evaluation Of Data Protection And Privacy Issues Introduced By Byod In Financial Institutions, Andy Miguel Santana

CCAC Theses and Dissertations

The idea of “bring your own device” (BYOD) allows organizational employees to conduct their tasks or processes on their own personal devices, has increased organizational efficiency significantly while allowing employees more flexibility. However, this approach also introduces major concerns about the security of organizational data as employees take their devices everywhere with them, opening more opportunities for unauthorized access to important data. Another major concern is the privacy of employee personal data. As many organizations implement BYOD, employees worry that with organizational monitoring and device management, their personal data is at risk as well. The problem this study tackles is …


Evaluating Aspect-Based Sentiment Analysis In Healthcare Drug Reviews Across Machine Learning, Deep Neural Networks, And Transformer Models, Eun Soo Park Jan 2025

Evaluating Aspect-Based Sentiment Analysis In Healthcare Drug Reviews Across Machine Learning, Deep Neural Networks, And Transformer Models, Eun Soo Park

All Graduate Theses, Dissertations, and Other Capstone Projects

Sentiment analysis has become a critical area of research in Natural Language Processing (NLP), enabling insights from unstructured text. Within this field, Aspect-Based Sentiment Analysis (ABSA) plays a practical role in domains such as healthcare, where patients drug reviews often contain diverse opinions across multiple aspects, including overall comments, perceived benefits, and side effects. However, aspect-level classification remains challenging due to class imbalance, subtle sentiment expression, and the limitations of traditional models. This research investigates the performance of three modeling paradigms: traditional machine learning (SVM, SVC, and XGBoost), deep learning (CNN-BiLSTM), and transformer-based approaches (DistilBERT sentence-pair classification). Using the UCI …


‘Waves Of Imagination’ Unconditional Spectogram Diffusion Using Diffusion Architecture., Rahul Vanukuri Jan 2025

‘Waves Of Imagination’ Unconditional Spectogram Diffusion Using Diffusion Architecture., Rahul Vanukuri

Computer Science and Engineering Theses - Archive

The swift evolution of wireless communication technologies,particularly in the field of rf signals or in CBRS bands,demands increasingly sophisticated signal processing techniques to ensure efficient transmission, reception, and spectrum management.Traditional approaches to signal generation and reconstruction, although effective in controlled environments, often struggle to cope with the challenges presented by real-world noisy conditions, hardware constraints, and limited access to large-scale datasets. In response to these limitations, this thesis explores the application of diffusion models—a class of generative models known for their ability to produce high-fidelity samples—to the domain of spectrogram generation for communication signals.

Different from conventional strategies to simulate …


Securing Secrets: Exploring The Aes Encryption And Key Security Capabilities Of Chatgpt, Kayla Taylor Jan 2025

Securing Secrets: Exploring The Aes Encryption And Key Security Capabilities Of Chatgpt, Kayla Taylor

Student Works

The development and increasing accessibility of generative artificial intelligence (AI) tools and large language models (LLMs) have allowed cryptographers to explore a variety of cryptanalysis problems in dynamic and interactive ways. Prompt engineering, the process by which input text is tested and refined to elicit a desired response from LLMs, is a nascent area of research that remains largely unexplored in many contexts, including cryptography. This study will explore the potential applications and limitations of prompt engineering in the context of Advanced Encryption Standard (AES) encryption and key security with OpenAI’s ChatGPT (GPT-4o) through two main objectives: First, given a …


System Dynamics With Insight Maker, Steven D'Alessandro, Fons Wijnhoven Jan 2025

System Dynamics With Insight Maker, Steven D'Alessandro, Fons Wijnhoven

Research outputs 2022 to 2026

This book offers a practical, model-driven pathway for reasoning about uncertain futures in business and public policy using system dynamics with Insight Maker. It begins by motivating why historical data alone often fail to predict social change, and it introduces the core language of system dynamics—stocks, flows, feedbacks, delays, and auxiliary variables—alongside the complementary use of agent-based modeling. Through business-relevant cases (e.g., park management trade-offs, epidemic–economy interactions, and industry competition), the book demonstrates how non-linear structure generates counter-intuitive dynamics, why scenario analysis is essential, and how to translate causal loop diagrams into stock-and-flow simulations. Readers are guided step-by-step to build, …


Fear: A Novel Framework For Representing Digital Forensic Artifacts In Knowledge Graphs, Allan Korol, Leslie F. Sikos Jan 2025

Fear: A Novel Framework For Representing Digital Forensic Artifacts In Knowledge Graphs, Allan Korol, Leslie F. Sikos

Research outputs 2022 to 2026

In digital forensics, knowledge graphs have demonstrated significant potential via software agent automation and knowledge discovery using encoded expert knowledge in, for example, the form of Semantic Web rules. These advancements have been limited in terms of efficiently encoding extracted digital artifacts into graph representation, the associated overhead of implementing frameworks to handle digital forensic evidence, and the lack of sharing of such code that is often a preamble to other research. This paper introduces a digital forensic framework, Forensic Extraction and Representation (FEAR), that enables a simplified process of accessing and encoding extracted digital forensic artifacts in semantic knowledge …


Attribute-Based Encryption With Searchable Encryption, Yang Yang Jan 2025

Attribute-Based Encryption With Searchable Encryption, Yang Yang

Research Collection School Of Computing and Information Systems

Attribute-based encryption (ABE) with searchable encryption is a notion that inherits the advantages of both ABE (Goyal et al., 2006) and searchable encryption (SE) (Boneh et al., 2004; Boneh and Waters, 2007) mechanisms to realize secure share and search for the outsourced data. ABE creates fine-grained access control system to prevent sensitive data from being accessed by unauthorized user or external attacker (Bethencourt et al., 2007). SE generates encrypted index for outsourced data such that it can be searched by a keyword trapdoor (or token) (Shi et al., 2007; Naveed et al., 2014), where the outsourced content and search keyword(s) …


Empowering Crisis Information Extraction Through Actionability Event Schemata And Domain-Adaptive Pre-Training, Yuhao Zhang, Siaw Ling Lo, Phyo Yi Win Myint Jan 2025

Empowering Crisis Information Extraction Through Actionability Event Schemata And Domain-Adaptive Pre-Training, Yuhao Zhang, Siaw Ling Lo, Phyo Yi Win Myint

Research Collection School Of Computing and Information Systems

One of the persistent challenges in crisis detection is inferring actionable information to support emergency response. Existing methods focus on situational awareness but often lack actionable insights. This study proposes a holistic approach to implementing an actionability extraction system on social media, including requirement gathering, selection of machine learning tasks, data preparation, and integration with existing resources, providing guidance for governments, civil services, emergency workers, and researchers on supplementing existing channels with actionable information from social media. Our solution leverages an actionability schema and domain-adaptive pre-training, improving upon the state-of-the-art model by 5.5% and 10.1% in micro and macro F1 …


How Do Selected Biomedical And Health Sciences Journals React To Submissions Of Artificial Intelligence (Ai) Assisted Manuscripts?, Misa Mi, Lin Wu, Yingting Zhang, Wendy Wu Jan 2025

How Do Selected Biomedical And Health Sciences Journals React To Submissions Of Artificial Intelligence (Ai) Assisted Manuscripts?, Misa Mi, Lin Wu, Yingting Zhang, Wendy Wu

Library Scholarly Publications

Background and Objectives: Generative artificial intelligence (GenAI) increasingly impacts research and scholarly communication. Given the evolving application of ChatGPT and other AI tools in scholarly communications, health sciences librarians must become cognizant of any existing journal publishing guidelines for AI-created or assisted manuscripts. The study aims to examine how scholarly biomedical and health sciences journals and publishers respond to submissions of these manuscripts and what requirements or policies have been put in place to guide and instruct authors on AI use.

Methods: We first retrieved and consolidated a list of journals representing disciplines in biomedical and health sciences from four …


A Bibliometric Analysis Of Ai-Driven Healthcare Literature Containing Kos Keywords: Trends, Themes, And Gaps, Julaine Clunis, Eric Asare Jan 2025

A Bibliometric Analysis Of Ai-Driven Healthcare Literature Containing Kos Keywords: Trends, Themes, And Gaps, Julaine Clunis, Eric Asare

STEMPS Faculty Publications

As artificial intelligence (AI) becomes increasingly embedded in healthcare applications, concerns have emerged around the trustworthiness, interpretability, and context-awareness of these systems. Knowledge Organization Systems (KOS) hold considerable potential to address these challenges by supporting semantic standardization, explainability, and domain alignment. This study presents a bibliometric analysis of scholarly publications referencing both AI and healthcare concepts to examine how KOS are positioned within this evolving discourse. The findings indicate that while early literature frequently and explicitly referenced KOS—such as ontologies, controlled vocabularies, and classification systems—their visibility has declined relative to newer paradigms such as machine learning and large language models. …


The Reliability Response To Patent Law’S Ai Challenges, Arti K. Rai Jan 2025

The Reliability Response To Patent Law’S Ai Challenges, Arti K. Rai

Faculty Scholarship

Pervasive AI use adds newfound importance to longstanding debates over patent timing and reliability. Patent claims on speculative ideas generated by AI, or even the infusion of speculative AI-generated ideas into the public domain, may defeat patent incentives for more careful research. Although challenges that AI use poses for patent validity requirements like human inventorship and nonobviousness have received more attention, reliability is equally important.

Indeed, as this Article argues, the issues are linked. If requirements for inventorship and nonobviousness were adjusted to emphasize reliability, a human role could be preserved, and AI use would not necessarily threaten patents. Currently, …


Cyber Warfare And The Future Of Conflict, Victor A. Mercado Jan 2025

Cyber Warfare And The Future Of Conflict, Victor A. Mercado

Graduate Theses/Dissertations

This thesis examines whether cyber warfare now poses a more immediate threat to U.S. national security than weapons of mass destruction (WMD). Cyber operations have become a dominant instrument of contemporary conflict, with malicious actors operating in a persistent “grey zone” that blurs traditional boundaries between war and peace. These operations target military and civilian entities, both directly and often as collateral damage due to the uncontrollable nature of cyber threats. WMDs, despite their catastrophic destructive potential, remain largely constrained by established deterrence frameworks.

The evolving nature of cyber warfare warrants comparison to WMD effects and impact, as cyber capabilities …


Efficient Task Scheduling In Cloud Infrastructures Using Dynamic Score-Based Allocation And Deep Q-Learning, Shadman Sakib Jan 2025

Efficient Task Scheduling In Cloud Infrastructures Using Dynamic Score-Based Allocation And Deep Q-Learning, Shadman Sakib

Graduate Theses/Dissertations

Cloud computing has grown rapidly in recent years, mainly due to the sharp increase in data transferred over the internet. This growth makes task scheduling a key and challenging part of cloud systems, as it helps distribute user requests across servers to minimize response time, prevent overloading, and ensure smooth user experience. This thesis proposes two novel approaches for dynamic task scheduling in cloud environments. First, a novel Score-Based Dynamic Load Balancing (SBDLB) strategy is developed, which leverages system parameters to allocate tasks efficiently across virtual machines (VMs) in data centers. SBDLB ensures balanced workload distribution by continuously evaluating VM …


Augmentation Of Quality Of Service, Security, And Trust In Edge-Enhanced Iot Networks Leveraging Blockchain, Kyle Matthew Whitlatch Jan 2025

Augmentation Of Quality Of Service, Security, And Trust In Edge-Enhanced Iot Networks Leveraging Blockchain, Kyle Matthew Whitlatch

Masters Theses

The meteoric rise of the Internet of Things (IoT) has led to multiple architectural schemas to handle the data these devices create. Edge-enhancement is a technique where groups of IoT report to a median layer to aggregate the data before relaying to the endpoint. These edges also open opportunities to perform more operations to ensure devices are behaving properly before committing the data to long term storage. By interconnecting these edges with a technology like blockchain, it is possible to have an interconnected and responsive system to ensure the Quality of Service (QoS) of the IoT devices within the architecture …


Performance Of Standard Medical Mllms On Ecg Image Data, Prisha Anil Jan 2025

Performance Of Standard Medical Mllms On Ecg Image Data, Prisha Anil

Masters Theses

This work presents a structured benchmarking study of multimodal large language models (MLLMs) applied to electrocardiogram (ECG) interpretation tasks. We evaluate three representative architectures: MedGemma, HuatuoGPT-Vision, and LLaVA-Med, across progressive experimental stages involving text-only structured prompt normalization, text–image fusion with ECG plots, and full multimodal fusion incorporating time-series signals. A standardized five-section cardiology prompt was designed to enforce consistent output structure and SCP-code alignment, enabling reproducible metric computation across models. Quantitative evaluation using BERTScore, token-level F1, and diagnostic accuracy demonstrates that HuatuoGPT-Vision achieves the highest semantic and diagnostic alignment, while MedGemma exhibits superior formatting stability and reproducibility. In contrast, LLaVA-Med …


Reinforcement Learning For Scheduling And Routing: Electric Vehicles Charging And Patrol Scheduling, Majid Ghasemi Jan 2025

Reinforcement Learning For Scheduling And Routing: Electric Vehicles Charging And Patrol Scheduling, Majid Ghasemi

Theses and Dissertations (Comprehensive)

This thesis offers a comprehensive exploration of Reinforcement Learning (RL), beginning with fundamental theoretical constructs, Markov Decision Processes, Dynamic Programming, Monte Carlo, and Temporal Difference methods, and extending into state-of-the-art deep RL approaches such as Deep Q-Networks (DQN) and policy-gradient algorithms. Through analytical experiments in controlled environments, the thesis demonstrates how distinct algorithmic choices (e.g., exploration techniques, eligibility traces, or network architectures) influence convergence and stability. These foundational insights pave the way for two in-depth case studies, which apply RL techniques to critical, real-world scheduling and routing challenges.

The first case study tackles the Electric Vehicle (EV) routing and charging …


Machine Learning Models For Location Prediction, Message Routing And Path Planning For Rescue Of Underground Miners, Abhay Goyal Jan 2025

Machine Learning Models For Location Prediction, Message Routing And Path Planning For Rescue Of Underground Miners, Abhay Goyal

Doctoral Dissertations

Self-rescue during underground mine disasters is vital for miner safety. Evolving hazards and post-disaster conditions demand solutions that enable navigation under severe communication and computational constraints. Centralized systems often fail in such rugged settings, while decentralized methods—particularly Delay Tolerant Networks (DTNs), proven in battlefields and space missions—offer distinct advantages for underground applications. This research addresses five core challenges: (i) predicting miners’ next locations on low-power devices using points of interest and movement sequences; (ii) delivering timely updates on safe routes, evacuation zones, and hazardous areas; (iii) evaluating energy efficiency and comparing graph-based approaches to existing methods; (iv) enabling edge-ready frameworks, …


Topics On Ai Fairness Preferences In Kidney Transplantation, Mukund Telukunta Jan 2025

Topics On Ai Fairness Preferences In Kidney Transplantation, Mukund Telukunta

Doctoral Dissertations

Modern kidney transplantation incorporates artificial intelligence (AI) decision-support systems which exhibit social discrimination due to biases inherited from training data. Although researchers have proposed various group-based fairness notions to assess biases in AI, it remains uncertain which criterion is most suitable for evaluating biases in such complex healthcare systems. This dissertation explores human perception of fairness to identify the most appropriate fairness criterion for assessing AI tools in kidney transplantation, focusing on the preferences of non-expert (e.g. public, patients) stakeholders. The study examines two distinct AI systems employed in kidney transplantation: a classification model and a regression model. Human subject …


A Spoofing Speech Detection Method Combining Multi-Scale Features And Cross-Layer Identification, Hongyan Yuan, Linjuan Zhang, Baoning Niu, Xianrong Zheng Jan 2025

A Spoofing Speech Detection Method Combining Multi-Scale Features And Cross-Layer Identification, Hongyan Yuan, Linjuan Zhang, Baoning Niu, Xianrong Zheng

Information Technology & Decision Sciences Faculty Publications

Pre-trained self-supervised speech models can extract general acoustic features, providing feature inputs for various speech downstream tasks. Spoofing speech detection, which is a pressing issue in the age of generative AI, requires both global information and local features of speech. The multi-layer transformer structure in pre-trained speech models can effectively capture temporal information and global context in speech, but there is still room for improvement in handling local features. To address this issue, a speech spoofing detection method that integrates multi-scale features and cross-layer information is proposed. The method introduces a multi-scale feature adapter (MSFA), which enhances the model’s ability …


Synthetic Data Generation Of Health And Demographic Surveillance Systems Data: A Case Study In A Low- And Middle-Income Country, Dorcas G. Mwigereri, Nigel T. Kamotho, Akbar K. Waljee, Ryan T. Rego, Eileen M. Weinheimer-Haus, Farhana Alarakhiya, Anthony K. Ngugi, W. Nicholson Price, Ji Zhu, Stephen Peter Wong, Geoffrey H. Siwo Jan 2025

Synthetic Data Generation Of Health And Demographic Surveillance Systems Data: A Case Study In A Low- And Middle-Income Country, Dorcas G. Mwigereri, Nigel T. Kamotho, Akbar K. Waljee, Ryan T. Rego, Eileen M. Weinheimer-Haus, Farhana Alarakhiya, Anthony K. Ngugi, W. Nicholson Price, Ji Zhu, Stephen Peter Wong, Geoffrey H. Siwo

Articles

Objective: To evaluate effectiveness of open-source generative models in producing high-quality tabular synthetic data using a Health and Demographic Surveillance System (HDSS) dataset from rural Kenya, as a proof of concept in a low- and middle-income (LMIC) setting.

Materials and Methods: Three open-source models (CTGAN, TableGAN, and CopulaGAN) were used to generate synthetic data from the Kaloleni/ Rabai HDSS dataset. To assess the quality of the synthetic datasets generated by each model, we performed fidelity, utility, and privacy tests.

Results: CTGAN outperformed the other models, producing synthetic data that closely mirrored the statistical properties of the real dataset while preserving …


The Future Of Ai Regulation In Drug Development: A Comparative Analysis, Gabriela Lenarczyk, Timo Minssen, W. Nicholson Price Ii, Arti Rai Jan 2025

The Future Of Ai Regulation In Drug Development: A Comparative Analysis, Gabriela Lenarczyk, Timo Minssen, W. Nicholson Price Ii, Arti Rai

Articles

As artificial intelligence (AI) transforms drug development, regulatory frameworks are evolving to oversee its implementation, particularly at the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA). This paper makes three contributions to understanding emerging regulatory approaches. First, we offer a comparative analysis of how these agencies have responded to AI-driven advances, incorporating new US executive orders and the European Union (EU)’s AI Act. Second, we propose a novel analytical framework to understand regulatory divergence: the FDA’s flexible, dialog-driven model contrasts with the EMA’s structured, risk-tiered approach, reflecting broader institutional and political-economic differences. While the former encourages …