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Articles 7201 - 7230 of 15584
Full-Text Articles in Entire DC Network
Synthesis, Characterization, And Biological Activity Of Spherical Nucleic Acid (Sna) Constructs For Cancer Therapy And Imaging, Colin Calabrese
Synthesis, Characterization, And Biological Activity Of Spherical Nucleic Acid (Sna) Constructs For Cancer Therapy And Imaging, Colin Calabrese
Arts & Sciences Graduate Student Theses and Dissertations
This dissertation focuses on the development of biocompatible oligonucleotide-based nanomaterials, known as spherical nucleic acids (SNAs), as therapeutic and diagnostic agents for intracellular gene regulation and in vivo cancer imaging by positron emission tomography (PET). SNAs consist of a nanoparticle core functionalized with a dense shell of oligonucleotides such as deoxyribonucleic acid (DNA). Detailed synthetic procedures and characterization of novel SNAs with purpose-built biocompatible core materials are described. The SNAs exhibit comparable chemical, physical and biological properties regardless of core composition. The functionalities of the SNAs were further tailored by deliberate design and chemical modification of their oligonucleotide sequences. The …
Universal Surface Engineering Of Transition Metals For Superior Electrocatalytic Hydrogen Evolution In Neutral Water, Bo You, Xuan Liu, Guoxiang Hu, Sheraz Gul, Junko Yano, De-En Jiang, Yujie Sun
Universal Surface Engineering Of Transition Metals For Superior Electrocatalytic Hydrogen Evolution In Neutral Water, Bo You, Xuan Liu, Guoxiang Hu, Sheraz Gul, Junko Yano, De-En Jiang, Yujie Sun
Chemistry and Biochemistry Faculty Publications
The development of low-cost hybrid water splitting-biosynthetic systems that mimic natural photosynthesis to achieve solar-to-chemical conversion is of great promise for future energy demands, but often limited by the kinetically sluggish hydrogen evolution reaction (HER) on the surface of nonprecious transition metal catalysts in neutral media. It is thus highly desirable to rationally tailor the reaction interface to boost the neutral HER catalytic kinetics. Herein, we report a general surface nitrogen modification of diverse transition metals (e.g. iron, cobalt, nickel, copper, and nickel-cobalt alloy), accomplished by a facile low-temperature ammonium carbonate treatment, for significantly improved hydrogen generation from neutral water. …
Characterization Of Reagent Pencils For Deposition Of Reagents Onto Paper-Based Microfluidic Devices, Cheyenne H. Liu, Isabelle C. Noxon, Leah E. Cuellar, Amanda L. Thraen, Chad Immoos, Andres W. Martinez, Philip J. Costanzo
Characterization Of Reagent Pencils For Deposition Of Reagents Onto Paper-Based Microfluidic Devices, Cheyenne H. Liu, Isabelle C. Noxon, Leah E. Cuellar, Amanda L. Thraen, Chad Immoos, Andres W. Martinez, Philip J. Costanzo
Chemistry and Biochemistry
Reagent pencils allow for solvent-free deposition of reagents onto paper-based microfluidic devices. The pencils are portable, easy to use, extend the shelf-life of reagents, and offer a platform for customizing diagnostic devices at the point of care. In this work, reagent pencils were characterized by measuring the wear resistance of pencil cores made from polyethylene glycols (PEGs) with different molecular weights and incorporating various concentrations of three different reagents using a standard pin abrasion test, as well as by measuring the efficiency of reagent delivery from the pencils to the test zones of paper-based microfluidic devices using absorption spectroscopy and …
Traceable Peo-Poly(Ester) Micelles For Breast Cancer Targeting: The Effect Of Core Structure And Targeting Peptide On Micellar Tumor Accumulation, Shyam M. Garg, Igor M. Paiva, Mohammad R. Vakili, Rania Soudy, Kate Agopsowicz, Amir H. Soleimani, Mary Hitt, Kamaljit Kaur, Afsaneh Lavasanifar
Traceable Peo-Poly(Ester) Micelles For Breast Cancer Targeting: The Effect Of Core Structure And Targeting Peptide On Micellar Tumor Accumulation, Shyam M. Garg, Igor M. Paiva, Mohammad R. Vakili, Rania Soudy, Kate Agopsowicz, Amir H. Soleimani, Mary Hitt, Kamaljit Kaur, Afsaneh Lavasanifar
Pharmacy Faculty Articles and Research
Traceable poly(ethylene oxide)-poly(ester) micelles were developed through chemical conjugation of a near-infrared (NIR) dye to the poly(ester) end by click chemistry. This strategy was tried for micelles with poly(ε-caprolactone) (PCL) or poly(α-benzyl carboxylate-ε-caprolactone) (PBCL) cores. The surface of both micelles was also modified with the breast cancer targeting peptide, P18-4. The results showed the positive contribution of PBCL over PCL core on micellar thermodynamic and kinetic stability as well as accumulation in primary orthotopic MDA-MB-231 tumors within 4–96 h following intravenous administration in mice. This was in contrast to in vitro studies where better uptake of PEO-PCL versus PEO-PBCL micelles …
Nanoparticle-Based Drug-Delivery Systems Studied By Second Harmonic Generation, Raju Ram Kumal
Nanoparticle-Based Drug-Delivery Systems Studied By Second Harmonic Generation, Raju Ram Kumal
LSU Doctoral Dissertations
Second harmonic generation (SHG) is used to study different types of colloidal nanoparticle drug-delivery systems. The surface charge density, electrostatic surface potentials, and ion adsorptions of 50 nm colloidal gold nanoparticle samples coated with mercaptosuccinic acid are determined using SHG measurements under varying NaCl and MgCl2 concentrations in water. Numerical solutions to the spherical Poisson-Boltzmann equation are fit to the SHG results to account for the nanoparticle surface curvature and ion adsorption to the Stern layer interface, showing excellent agreement with electrophoretic mobility measurements. In another study, nanoparticles of gold, silver and polystyrene are functionalized with microRNA using a …
How Strongly Do Oysters Stick?, Nicolás M. Morato, Andrés M. Tibabuzo, Jonathan J. Wilker
How Strongly Do Oysters Stick?, Nicolás M. Morato, Andrés M. Tibabuzo, Jonathan J. Wilker
The Summer Undergraduate Research Fellowship (SURF) Symposium
Biological adhesives are a type of interfacial material that has incredible potential to generate new biomimetic compounds that can replace current strong, but toxic, adhesives. Therefore, a study of the chemical composition and mechanical properties of those bio-adhesives is necessary. However, in the case of oysters, despite known chemical characterization of the adult’s adhesive, there are almost no studies on its mechanical properties. Furthermore, there is no available information on the adhesive properties of spat (oysters in their larvae state). Herein, we present the first mechanical characterization of the spat adhesive, measuring its adhesion strength by hydrodynamic determination using a …
Applying Machine Learning To Computational Chemistry: Can We Predict Molecular Properties Faster Without Compromising Accuracy?, Hanjing Xu, Pradeep Gurunathan, Lyudmila Slipchenko
Applying Machine Learning To Computational Chemistry: Can We Predict Molecular Properties Faster Without Compromising Accuracy?, Hanjing Xu, Pradeep Gurunathan, Lyudmila Slipchenko
The Summer Undergraduate Research Fellowship (SURF) Symposium
Non-covalent interactions are crucial in analyzing protein folding and structure, function of DNA and RNA, structures of molecular crystals and aggregates, and many other processes in the fields of biology and chemistry. However, it is time and resource consuming to calculate such interactions using quantum-mechanical formulations. Our group has proposed previously that the effective fragment potential (EFP) method could serve as an efficient alternative to solve this problem. However, one of the computational bottlenecks of the EFP method is obtaining parameters for each molecule/fragment in the system, before the actual EFP simulations can be carried out. Here we present a …
Exploring Flexible Configurations Of A Custom Multipath Lc –Ms For Small Molecules And Protein Analysis, Dananjaya Kalu Appulage
Exploring Flexible Configurations Of A Custom Multipath Lc –Ms For Small Molecules And Protein Analysis, Dananjaya Kalu Appulage
Chemistry & Biochemistry Dissertations - Archive
There are diseases where both small molecules and proteins are found as disease indicators. In the usual analysis of small molecules, proteins are precipitated out during the sample preparation. In the small molecule quantitation, triple quadrupole mass spectrometers (QqQ- MS) are commonly used even in the clinical lab settings. Even though QqQ is giving only unit resolution, it is highly sensitive and specific specially when it is used in the multiple reaction monitoring (MRM) mode. In the liquid chromatography method development, automation of column and mobile phase screening could save significant amount of operators’ time. The use of Shimadzu Nexera …
F₄₂₀ Cofactor Dependent Enzymes : Kinetic, Mechanistic And Structural Characterization Of F₄₂₀-Dependent Glucose-6-Phosphate Dehydrogenase (Fgd) From Mycobacterium Tuberculosis, Mercy A. Oyugi
Chemistry & Biochemistry Dissertations - Archive
F₄₂₀-dependent glucose-6-phosphate dehydrogenase (FGD) from Mycobacterium tuberculosis (Mtb) is one of a few enzymes that utilize the unique F₄₂₀ cofactor for catalysis. FGD catalyzes the first committed step of the pentose-phosphate pathway, where it uses the oxidized F₄₂₀ cofactor to convert glucose-6-phosphate (G6P) to 6-phosphogluconolactone. Mtb is the bacteria that causes Tuberculosis (TB), which is currently the world’s deadliest bacterial disease. The pentose-phosphate pathway is important for survival of Mtb, since it provides precursors for nucleic acid synthesis and yields reducing equivalents that are essential for other metabolic pathways. The fact that FGD catalyzes the committed step of the pentose-phosphate …
Development Of Ultrahigh Performance Chiral Phases For Separations Approaching The Speed Of Sensors, Darshan C. Patel
Development Of Ultrahigh Performance Chiral Phases For Separations Approaching The Speed Of Sensors, Darshan C. Patel
Chemistry & Biochemistry Dissertations - Archive
Chromatography using chiral stationary phases is the most effective and popular technique for qualitative and quantitative analysis of enantiomers in the pharmaceutical, agricultural, and food industry, among many others. Given the prevalence of chirality in nature, creation of new technologies for improving the speed and performance of chiral separations can provide immediate and significant benefits. This dissertation focuses on development of ultrahigh performance chiral phases which can provide separations at speeds that approach the speed of typical sensors and thereby enable chromatography as a real-time analysis tool. A variety of chiral selectors namely macrocyclic glycopeptides (teicoplanin, teicoplanin aglycone, vancomycin), cyclic …
Epigenetic Mechanism Of Regulation Of Hox Genes And Neurotransmitters Via Hormones And Lncrna, Paromita Deb
Epigenetic Mechanism Of Regulation Of Hox Genes And Neurotransmitters Via Hormones And Lncrna, Paromita Deb
Chemistry & Biochemistry Dissertations - Archive
Endocrine disrupting chemicals (EDCs) are classes of environmental contaminants whose exposure even at very low concentrations interfere with normal endocrine signaling and induce many adverse health effects including increased risk of birth defects, diabetes, obesity, abnormal reproduction, and cancer. EDC exposure alters the epigenetic programming of cells resulting in altered gene expression and regulation and cell signaling. These EDCs include bisphenol-A (BPA), diethylstilbesterol (DES), polychlorinated biphenyl (PCB), phthalates, phytoestrogens, methoxychlor, fungicides, insecticide, herbicide, and some heavy metals. As a part of my work, I have investigated epigenetic impacts of EDCs on HOX (homeobox containing genes) genes, which are critical players …
Enrichment And Identification Of Disulfide Bonded Peptides By Tandem Mass Spectrometry, Pooja Rajeshbhai Ramanuj
Enrichment And Identification Of Disulfide Bonded Peptides By Tandem Mass Spectrometry, Pooja Rajeshbhai Ramanuj
Chemistry & Biochemistry Theses - Archive
Proteins are Comprised of different amino acids which can undergo various modifications known as post-translational modifications (PTMs). Amino acid’s side chains are the most common sites for the PTMs. Cysteine side chain can undergo several PTMs and one very common one is disulfide bond formation. Disulfide bond aids in maintaining protein tertiary structures, its identification is an inevitable aspect in studying protein functions. Furthermore, disulfide bonds are potential targets to develop new protein therapeutics for life-threatening diseases such as cancer. Literature surveys revealed several methods to identify disulfide bonds, which require either high quality sample or are highly laborious. Moreover, …
Toxicity Study Of Cace₂S₄, Wafa Tonny
Toxicity Study Of Cace₂S₄, Wafa Tonny
Chemistry & Biochemistry Theses - Archive
In recent years, rare earth sulfides have received attention for their interesting thermoelectric and optical properties.1 They exhibit a fairly wide range of colors, which makes them promising candidates as pigments.2 The demand for red colored pigments in industrial application is high but the current ones in use are not environmentally friendly. This has garnered attention towards the rare-earth sulfides. Among the rare-earth sulfide compounds, Ce₂S₃ is a highperformance pigment of red color. It is particularly interesting as doping with alkaline earth metal stabilizes the structure of Ce₂S₃ at low temperature and plays a role in tuning its color from …
Functionalization Of Indium-Based Quantum Dots For Use As A Non-Viral Gene Therapy Vector, Nicholas A. Mundt
Functionalization Of Indium-Based Quantum Dots For Use As A Non-Viral Gene Therapy Vector, Nicholas A. Mundt
Graduate Theses/Dissertations
This work aims to develop functionalized, water-soluble indium-based quantum dots (QDs) as a non-viral gene therapy vector. The QDs were solubilized in water by exchanging native hydrophobic surface ligands with 11-mercaptoundecanioc acid (MUA); an amphiphilic ligand providing terminal carboxylate groups that impart water solubility to the QDs. The aqueous QDs were then functionalized with a terminal tertiary amine to impart a positive surface charge, allowing negatively-charged DNA to complex with the nanoparticles. The QDs were characterized via electrophoresis to determine their ability to bind DNA. Results show that further work is needed to optimize DNA binding. In addition, this work …
Ab Initio Methyl Linoleate Bond Dissociation Energies: First Principles Fishing For Wise Crack Products, Zachary Ryan Wilson
Ab Initio Methyl Linoleate Bond Dissociation Energies: First Principles Fishing For Wise Crack Products, Zachary Ryan Wilson
Graduate Theses/Dissertations
With the prices of petroleum reflecting demand for this finite resource, attention has been turned to alternative sources of energy. Biodiesel, defined as fatty acid methyl esters (FAMEs), exhibits many of the same properties as conventional diesel but is derived from biological sources. FAMEs are subsequently thermally cracked to form more light-weight petrochemical products. I aim to further understand the thermal cracking procedure, at an atomic-level, in hopes that this may aid in future engineering of viable fuels. I studied the effective computational modeling of bond disassociations in the FAME methyl linoleate. Bond dissociation in a 44-reaction database with known …
Electrokinetically Operated Integrated Microfluidic Devices For Preterm Birth Biomarker Analysis, Mukul Sonker
Electrokinetically Operated Integrated Microfluidic Devices For Preterm Birth Biomarker Analysis, Mukul Sonker
Theses and Dissertations
Microfluidics is a vibrant and expanding field that has the potential for solving many analytical challenges. Microfluidics shows promise to provide rapid, inexpensive, efficient, and portable diagnostic solutions that can be used in resource-limited settings. Microfluidic devices have gained immense interest as diagnostic tools for various diseases through biomarker analysis. My dissertation work focuses on developing electrokinetically operated integrated microfluidic devices for the analysis of biomarkers indicative of preterm birth risk. Preterm birth (PTB), a birth prior to 37 weeks of gestation, is the most common complication of pregnancy and the leading cause of neonatal deaths and newborn illnesses. In …
Crispr/Cas9 In Leishmania Genome Editing : Towards A Proof Of Concept, Zein Kasbo
Crispr/Cas9 In Leishmania Genome Editing : Towards A Proof Of Concept, Zein Kasbo
Theses, Dissertations and Culminating Projects
Leishmaniasis is a parasitic Neglected Tropical Disease (NTD) that affects mostly poor countries of the third word due to their limited access to clean water and health care. The disease is transmitted through the bite of a sand fly of the genus Phlebotomus in the Old World, and of the genus Lutzomyia in the New World. Historically, NTDs have not been given adequate attention or research funding and finding curative treatments has been slow. However, the fact that the insect vector and the parasite can live and thrive in any ecological system in the world, and under the current circumstances …
Renewed Significance Of Ras Gtpases, Michael Wey
Renewed Significance Of Ras Gtpases, Michael Wey
Chemistry & Biochemistry Dissertations - Archive
The Ras superfamily of GTPases act as molecular switches and play a critical role in intracellular signal transduction. These GTPases cycle between an active GTP- bound form and an inactive GDP-bound form to regulate a myriad of cellular processes. However, this classical model of Ras regulation does not accurately project the entire picture of Ras regulation. This work discusses non-classical and newly discovered elements of the Ras signaling network. While intrinsic kinetic properties of Ras are included in the classical model of Ras regulation, the importance of them is understated. We show that the development Costello Syndrome from somatic Harvey …
Instrumental Aspects Of Oxygen Sensing: Quantitation And Recalibration Of A Biofouled Oxygen Sensor, Marlena Patrick
Instrumental Aspects Of Oxygen Sensing: Quantitation And Recalibration Of A Biofouled Oxygen Sensor, Marlena Patrick
Graduate Theses and Dissertations
In vivo oxygen sensing is a critical area of research for medical applications, such as ischemic stroke, but this important topic is not fully understood or resolved. In addition, the best method for calibration of in vivo sensors is as yet undetermined. For all implantable devices, biofouling, the adsorption of biological material to the device surface, is another significant problem with no clear or well-defined solution. One method employed is to apply a protective polymer membrane to the sensor surface in order to minimize the adsorption of biological material. The work described here investigates two polymers applied to a gold …
Enantioselective Γ- And Δ -Borylation Of Unsaturated Carbonyl Derivatives: Synthesis, Mechanistic Insights, And Applications, Gia L. Hoang
Enantioselective Γ- And Δ -Borylation Of Unsaturated Carbonyl Derivatives: Synthesis, Mechanistic Insights, And Applications, Gia L. Hoang
Department of Chemistry: Dissertations, Theses, and Student Research
Chiral boronic esters are valuable synthetic intermediates widely used in a variety of stereospecific transformations. Transition metal-catalyzed asymmetric hydroboration (CAHB) of alkenes is among the most popular methods for their preparation. Enantioselective hydroboration of activated alkenes (i.e., vinyl arene derivatives or conjugated carbonyl compounds) have been extensively studied by many research groups. We, on the other hand, are interested in enantioselective hydroboration of unactivated alkenes utilizing coordinating functional groups (e.g., carbonyl derivatives) to give functionalized, chiral boronic esters. While conjugate addition and C–H activation methodologies provide efficient alternatives to CAHB for enantioselective beta-borylation of carbonyl compounds, direct gamma- and delta-borylations …
Geochemical Fractionation, Speciation, And Bioavailability Of Heavy Metals In Stream Sediments In Aurora, Mo, Miles Pearson
Geochemical Fractionation, Speciation, And Bioavailability Of Heavy Metals In Stream Sediments In Aurora, Mo, Miles Pearson
Graduate Theses/Dissertations
Stream sediments from Chat Creek in Aurora, MO, part of the former Tristate Mining District, were digested via a sequential extraction procedure modeled after the Tessier method. Prior sampling had shown elevated levels of zinc, lead, and cadmium in sediments located near former chat piles. Metals in sediments were divided into four geochemical fractions: 1) easily exchangeable, 2) carbonate-bound, 3) iron-manganese oxides-bound, and 4) organic matter-bound. The distribution of the metals within these fractions can help predict the bioavailability and speciation of said metals. The majority of metals were contained in the third and to a lesser extent the fourth …
Chlorate Formation In On-Site Hypochlorite Generation Facilities: Effects Of Temperature, Ph, And Storage Times, Lukas Simon Kriem
Chlorate Formation In On-Site Hypochlorite Generation Facilities: Effects Of Temperature, Ph, And Storage Times, Lukas Simon Kriem
Graduate Theses/Dissertations
Drinking water is one of the fundamental pillars of modern society, and it is crucial that pathogen-free drinking water be provided to communities. Currently, one third of all drinking water in the U.S. is being disinfected using hypochlorite and the number is rising. However, use of hypochlorite is facing the issue of a hypochlorite byproduct, chlorate ion, which at high concentrations is considered a health risk to humans. During and after its electrolytic generation process, hypochlorite may go through a disproportionation reaction to form chlorate and chloride, a process which is thermodynamically favored. Even though chlorate in drinking water is …
Investigating Hydrothermal And Radiation Effects On Nitrogen Heterocycles Relevant To Meteorite Parent Bodies, Phillip G. Hammer
Investigating Hydrothermal And Radiation Effects On Nitrogen Heterocycles Relevant To Meteorite Parent Bodies, Phillip G. Hammer
Boise State University Theses and Dissertations
Organic compounds in meteorites were likely transformed by a variety of processes on the asteroid parent body including aqueous, thermal, and radiolytic alteration. Previous studies have identified a suite of purine nitrogen heterocycles in carbonaceous chondrites (a class of meteorites) and determined that their likely origin was due to cyanide chemistry. The thesis research described here consisted of two parts: investigating thermal effects on aqueous ammonium cyanide reactions and the production/survivability of organics (Chapter 2) and investigating gamma radiation effects on purine nitrogen heterocycles to understand how prolonged radiation exposure influenced the distribution and abundance of nitrogen heterocycles measured in …
Improved Partial Charge Models In Siliceous Zeolites For The Simulation Of Adsorption And Identification Of Catalytic Sites, Jarod J. Wolffis
Improved Partial Charge Models In Siliceous Zeolites For The Simulation Of Adsorption And Identification Of Catalytic Sites, Jarod J. Wolffis
UNLV Theses, Dissertations, Professional Papers, and Capstones
Utilization of computational modelling and simulation is expanding as computer processing power has increased and as new tools have been developed. This thesis focuses on efforts to improve the accuracy of simulations in aluminosilicate zeolites, an industrially important category of materials for catalysis and separations. For these sorbents, partial atomic charge represents a critical parameter in molecular mechanics simulations, determining the Coulombic non-bonding interaction. Partial charges may also be used as a measure of important physical parameters of the system such as the degree of covalency or the relative acidity of catalytic sites. We compare several common methods for predicting …
Electrogenerated Chemiluminescent Studies Of 9,10-Diphenylanthracene, Rubrene, Tris(2,2'-Bipyridine)Ruthenium(Ii) Species, And Their Derivatives For Sensitive Detection Of Biomolecules, Pradip Bastola
Dissertations
This dissertation explored and investigated the coreactant electrogenerated chemiluminescent (ECL) properties of unmixed and mixed systems of highly efficient ECL emitters, such as 9,10-diphenylanthracene (DPA), rubrene (RUB), and tris(2,2′-bipyridine)ruthenium(II) [(Ru(bpy)32+)] species as well as their water-soluble derivatives, which can serve as ECL labels for sensitive bioanalysis of single or multiple analytes. The screening of most favorable common ECL coreactants, their concentration effects along with the effect of working electrode materials on ECL behavior, and energy transfer related interactions between ECL emitters were systematically investigated. In addition, a strategy for improvement of ECL signals with the use of …
Transient Absorption Studies Of Cdse Nanocluster Passivated With Phenyldithiocarbamate Ligands., Yizhou Xie
Transient Absorption Studies Of Cdse Nanocluster Passivated With Phenyldithiocarbamate Ligands., Yizhou Xie
Electronic Theses and Dissertations
Semiconductor nanocluster (SCNC) research is a rapidly growing field driven by the promising fact that properties of such materials can be tailored by modifying their size, shape, and structure. Combination of nanocluster and organic ligands provides even wider possibilities of design and development of effective and task-specific nanostructures. Understanding of and, eventually, control of energetics, interfacial interaction, and photoinduced processes in such highly heterogeneous structures is critical to invention of novel materials including those in photovoltaic devices. In the newly established Ultrafast Laser Facility (ULF), transient absorption pump-probe spectroscopy (TAPPS) has been employed to investigate the electron transfer (ET) and …
Electrophilic Catalysis Using Heterobimetallic Complexes, Whitney Kaye Walker
Electrophilic Catalysis Using Heterobimetallic Complexes, Whitney Kaye Walker
Theses and Dissertations
Conventional ligand design in transition metal catalysis capitalizes on the ability of phosphorous, nitrogen, carbon, oxygen, and sulfur-based donors to modify the steric and electronic properties of a reactive metal center. Heterobimetallic transition metal complexes that contain a dative metal-metal bond provide a unique approach to ligand design where the reactivity of the metal center can be modified by metal-metal electronic communication. Our laboratory is interested in using the unique properties of heterobimetallic complexes to address significant limitations in current transition metal catalysis. My PhD work has focused on the ability of early/late transition metal heterobimetallic complexes to facilitate catalysis …
Synthesis And Catalytic Evaluation Of Novel C-Alpha-Methyl-Beta-Proline Analogues, And Concise Synthetic Approach To Nh-Fmoc-S-Trityl-C-Alpha-Methyl Cysteine, Hari Kiran Kotapati
Synthesis And Catalytic Evaluation Of Novel C-Alpha-Methyl-Beta-Proline Analogues, And Concise Synthetic Approach To Nh-Fmoc-S-Trityl-C-Alpha-Methyl Cysteine, Hari Kiran Kotapati
Dissertations
In the field of chemistry there is a growing demand for small molecule organocatalysts such as amino acids, more specifically proline and its analogues, which could catalyze various key chemical reactions in the synthesis of several biologically important molecules. Even though natural proline is reported to catalyze various chemical reactions, its use as organocatalyst is limited mainly due to the solubility issues in the reaction media and high catalyst loadings, which is not very ideal for bulk scale manufacturing. To address these limitations we planned to develop unnatural analogues of proline that could catalyze the reactions with lower catalyst loadings …
Biocidal Defeat Agents Produced By Silver-Iodine Nanoenergetic Gas Generators, Ivan Davila
Biocidal Defeat Agents Produced By Silver-Iodine Nanoenergetic Gas Generators, Ivan Davila
Theses and Dissertations
Nanostructured aluminum (Al), iodine pentoxide (I2O5) nano-rods, and silver oxide (Ag2O) nanoparticles, (Al-I2O5-Ag 2O) were used to compose the ternary thermite composition that serves as a Nanoenergetic Gas Generator (NGG). This composition produces biocidal gases giving the mixture the ability to destroy highly pathogenic microorganisms or bacteria. The dissemination of the biocidal gas in combustion chamber was observed using a high-speed camera. The testing of NGG combustion process against the living Escherichia coli (E.coli) K-12 strain cells, that were cultivated/placed on the sample/chamber surfaces, demonstrated that iodine and silver atoms clouds were deposited to the bacteria surface. The 10/75/15 wt …
Microwave-Promoted Iminyl Radical Cyclizations For The Synthesis Of Azaheterocycles And The Total Synthesis Of Yaku'amide A, Yu Cai
Theses and Dissertations
Two different research projects are described in this dissertation. The first one focuses on microwave-promoted iminyl radical cyclization for the formation of azaheterocycles which are embedded within numerous pharmaceuticals and biologically active natural products (such as clindamycin, eletriptan, moxiflaxin, etc.). We are quite interested in this project because of the significance of nitrogen-containing heterocycles as pharmaceuticals and organocatalysts combined with the need for safe, simple, and economical means of constructing them. We have successfully developed an efficient one-step synthesis of 2-acylpyrroles and diastereoselective dihydropyrroles from readily available oxime ether substrates. This remarkably efficient and environmentally friendly methodology should be useful …